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Khalaf Majid - - 2013
ABSTRACT: A new leg voxel model in two different positions (straight and bent) has been developed for in vivo measurement calibration purposes. This voxel phantom is a representation of a human leg that may provide a substantial enhancement to Monte Carlo modeling because it more accurately models different geometric leg ...
Mordelet Fantine - - 2013
Elucidating the structure of gene regulatory networks (GRN), i.e., identifying which genes are under control of which transcription factors, is an important challenge to gain insight on a cell's working mechanisms. We present SIRENE, a method to estimate a GRN from a collection of expression data. Contrary to most existing ...
Kanehisa Minoru - - 2013
KEGG ( http://www.genome.jp/kegg/ ) is an integrated database resource for linking genomes or molecular datasets to molecular networks (pathways, etc.) representing higher-level systemic functions of the cell, the organism, and the ecosystem. Major efforts have been undertaken for capturing and representing experimental knowledge as manually drawn KEGG pathway maps and ...
Calandrino R - - 2013
ABSTRACT: The goal of establishing prompt localization of the malignant spread or recurrence of a tumor has found a powerful solution in the definition of follow-up protocols, which include the indication for CT scans on an annual or semiannual basis. In the case of long-surviving patients, however, this approach will ...
Hall David W - - 2013
We explore the evolutionary origins of dosage compensation (DC) in sex chromosomes in the context of metabolic control theory. We consider first the cost of gene loss (hemizygosity) per se in reducing flux, and examine two relationships between flux and fitness (linear and Gaussian) to calculate a fitness cost of ...
Pawel David J - - 2013
ABSTRACT: The U.S. Environmental Protection Agency (EPA) has updated its estimates of cancer risks due to low doses of ionizing radiation for the U.S. population, as well as their scientific basis. For the most part, these estimates were calculated using models recommended in the recent National Academy of Sciences' (BEIR ...
Lin Cheng-Li - - 2013
Equinus of the ankle is a common deformity in spastic cerebral palsy. Many methods have been developed to lengthen the Achilles tendon to correct the deformity. A new mesh Achilles tendon lengthening (ATL) procedure that might decrease immobilization and promote recovery was performed in 36 tendons with equinus deformity (22 ...
Chow April M AM Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR, - - 2013
Cyclic decapeptide CGLIIQKNEC (CLT1) has been demonstrated to target fibronectin-fibrin complexes in the extracellular matrix of different tumors and tissue lesions. Although liver fibrosis is characterized by an increased amount of extracellular matrix consisting of fibril-forming collagens and matrix glycoconjugates such as fibronectin, we aimed to investigate the feasibility of ...
Hugo Willy - - 2013
Many important biological processes, such as the signaling pathways, require protein-protein interactions (PPIs) that are designed for fast response to stimuli. These interactions are usually transient, easily formed, and disrupted, yet specific. Many of these transient interactions involve the binding of a protein domain to a short stretch (3-10) of ...
Parpura Vladimir V Department of Neurobiology, Center for Glial Biology in Medicine, Atomic Force Microscopy and Nanotechnology Laboratories, Civitan International Research Center, Evelyn F. McKnight Brain Institute, University of Alabama, Birmingham, AL 35294, USA. - - 2013
The brain operates through complex interactions in the flow of information and signal processing within neural networks. The 'wiring' of such networks, being neuronal or glial, can physically and/or functionally go rogue in various pathological states. Neuromodulation, as a multidisciplinary venture, attempts to correct such faulty nets. In this review, ...
Boado Ruben J RJ ArmaGen Technologies, Inc., Santa Monica, CA 90401, - - 2013
Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder of the brain caused by mutations in the gene encoding the lysosomal sulfatase, arylsulfatase A (ASA). It is not possible to treat the brain in MLD with recombinant ASA, because the enzyme does not cross the blood-brain barrier (BBB). In the present ...
Wilkinson A V AV Division of Epidemiology, Human Genetics and Environmental Science, University of Texas School of Public Health, Austin Regional Campus, Austin, TX 78701, USA. - - 2013
Many studies examining genetic influences on physical activity (PA) have evaluated the impact of single nucleotide polymorphisms (SNPs) related to the development of lifestyle-related chronic diseases, under the hypothesis that they would be associated with PA. However, PA is a multidetermined behavior and associated with a multitude of health consequences. ...
Zhong Lina L Department of Chemical Engineering, The Grove School of Engineering, The City College of New York, 140th Street at Convent Avenue, New York, New York 10031, United - - 2013
The strict requirement of constructing a native lipid environment to preserve the structure and functionality of membrane proteins is the starting constraint when building biomaterials and sensor systems from these biomolecules. To enhance the viability of supported biomembranes systems and build new ligand display interfaces, we apply rationally designed peptides ...
Perkins Timothy T - - 2013
OmpR is a multifunctional DNA binding regulator with orthologues in many enteric bacteria that exhibits classical regulator activity as well as nucleoid-associated protein-like characteristics. In the enteric pathogen Salmonella enterica, using chromatin immunoprecipitation of OmpR:FLAG and nucleotide sequencing, 43 putative OmpR binding sites were identified in S. enterica serovar Typhi, 22 ...
Guttenplan Sarah B SB Department of Biology, Indiana University, Bloomington, IN 47405, - - 2013
Bacterial flagella are highly conserved molecular machines that have been extensively studied for assembly, function and gene regulation. Less studied is how and why bacteria differ based on the number and arrangement of the flagella they synthesize. Here we explore the cell biology of peritrichous flagella in the model bacterium ...
Saint Clair Erica C EC Department of Physics, Photonics Center and Molecular Biophysics Laboratory, Boston University, Boston, Massachusetts 02215, - - 2012
Archaerhodopsin 3 (AR3) is a light driven proton pump from Halorubrum sodomense that has been used as a genetically targetable neuronal silencer and an effective fluorescent sensor of transmembrane potential. Unlike the more extensively studied bacteriorhodopsin (BR) from Halobacterium salinarum, AR3 readily incorporates into the plasma membrane of both E. ...
Bubunenko Mikhail M Frederick National Laboratory for Cancer Research, Basic Research Program, SAIC-Frederick, Inc., Frederick, MD 21702, - - 2013
Escherichia coli NusA and NusB proteins bind specific sites, such as those in the leader and spacer sequences that flank the 16S region of the ribosomal RNA transcript, forming a complex with RNA polymerase that suppresses Rho-dependent transcription termination. Although antitermination has long been the accepted role for Nus factors ...
Ibrahim Diaa A DA National Organization for Drug Control & Research, Cairo, Gizaa, - - 2012
Tuberculosis (TB) is a global health threat with nearly 500 000 new cases of multidrug-resistant TB estimated to occur every year, so new drugs are desperately needed. A number of current antimycobacterial drugs work by interfering with the biosynthesis of key components of the mycolylarabinogalactan (mAG). In light of this ...
Creutz Carl E CE Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA. - - 2012
Biological membranes are exposed to a number of chemical and physical stresses that may alter the structure of the lipid bilayer in such a way that the permeability barrier to hydrophilic molecules and ions is degraded. These stresses include amphiphilic molecules involved in metabolism and signaling, highly charged polyamines, membrane-permeating ...
Ellis Katie E KE Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, - - 2012
All known active forms of diheme bacterial cytochrome c peroxidase (bCcP) enzymes are described by a homodimeric state. Further, the majority of bCcPs reported display activity only when the high-potential electron transfer heme of the protein (Fe(H)) is reduced to the ferrous oxidation state. Reduction of Fe(H) results in a ...
Gushwa Nathan N NN Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94158, United - - 2012
Src-family tyrosine kinases play pivotal roles in human physiology and disease, and several drugs that target members of this family are in clinical use. None of these drugs appear to discriminate among closely related kinases. However, assessing their selectivity toward endogenous kinases in living cells remains a significant challenge. Here, ...
Pei Yanzhong - - 2012
Thermoelectric generators have been used for powering spacecrafts since the 1950s. Low material efficiency limits its application on a large scale. On page 6125, G. J. Snyder, Yanzhong Pei, and Heng Wang review strategies of engineering the electronic band structure, such as effective mass, degeneracy and band gap, which increase ...
Wen Liping - - 2012
An efficient and reversible ionic gating that can be activated by pH and light is demonstrated on page 6193 by Lei Jiang, Zhishan Bo, and co-workers, by modifying a malachite green derivative on the interior surface of an ion track-etched conical nanochannel. The switches between the OFF-state and the ON-state ...
Zheng Jing J Molecular Science and Biomedicine Laboratory, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, 410082, - - 2012
A DNA configuration switch is designed to fabricate a reversible and regenerable Raman-active substrate. The substrate is composed of a Au film and a hairpin-shaped DNA strand (hot-spot-generation probes, HSGPs) labeled with dye-functionalized silver nanoparticles (AgNPs). Another ssDNA that recognizes a specific trigger is used as an antenna. The HSGPs ...
Shalek Alex K AK Department of Chemistry, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United - - 2012
A circuit level understanding of immune cells and hematological cancers has been severely impeded by a lack of techniques that enable intracellular perturbation without significantly altering cell viability and function. Here, we demonstrate that vertical silicon nanowires (NWs) enable gene-specific manipulation of diverse murine and human immune cells with negligible ...
Nakai Shigeru - - 2012
A nationwide statistical survey of 4226 dialysis facilities was conducted at the end of 2010, and 4166 facilities (98.6%) responded. The number of new patients introduced into dialysis was 37 512 in 2010. This number has decreased for two consecutive years since it peaked in 2008. The number of patients who ...
Wallis Laura - - 2012
Getting past "We've always done it this way" is crucial.
Zunner Brian P - - 2012
An exploration of bias in health care and how it affects this population.
Gnyawali Subodh - - 2012
To identify the optical needs of students with low vision studying in the integrated schools for the blind in Nepal. A total of 779 blind and vision-impaired students studying in 67 integrated schools for the blind across Nepal were examined using the World Health Organization/Prevention of Blindness Eye Examination Record ...
Lakhiani Chrisovalantis C Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, - - 2012
The most untoward aspect of the anterolateral thigh is the complexity of the local vasculature. Failure to understand its variability can lead to vascular flap embarrassment and tissue loss. The authors present a comprehensive summary of the vascular anatomy of the anterolateral thigh. A MEDLINE search was performed for articles ...
Rasko Yvonne M YM Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9132, - - 2012
Secondary rhytidectomy procedures present an additional level of complexity in comparison with primary procedures. Patients may seek secondary rhytidectomy, in part, as a result of complications stemming from the initial procedure, because of the natural process of aging, or a combination of the two. The aim of this literature review ...
do Nascimento Antônia Sâmia F - - 2012
A lectin from seeds of Dioclea lasiocarpa (DLL) was purified in a single step by affinity chromatography in a Sephadex G-50 column. DLL haemagglutinated rabbit erythrocytes showing stability even after 1 h of exposure to a different pH values (optimal between pH 6.0 and 8.0) but was inhibited after incubation with ...
Wang Xin - - 2012
Coronary heart disease (CHD) is characterized by inflammatory process and endothelial dysfunction. To investigate angiopoietin-2 (Ang-2) profiles, we evaluated serum Ang-2 levels in different types of CHD in 166 subjects. Ang-2 was measured by enzyme-linked immunosorbent assay. Serum Ang-2 levels were significantly elevated in patients with CHD and gradually increased ...
Wang Yuanyuan - - 2012
Although there is evidence for a beneficial effect of increased quadriceps strength on knee symptoms, the effect on knee structure is unclear. We undertook this study to examine the relationship between change in vastus medialis cross-sectional area (CSA) and knee pain, tibial cartilage volume, and risk of knee replacement in ...
Yang Rong Ya - - 2012
This is the first report of the genome sequence of Trichosporon asahii environmental strain CBS 8904, which was isolated from maize cobs. Comparison of the genome sequence with that of clinical strain CBS 2479 revealed that they have >99% chromosomal and mitochondrial sequence identity, yet CBS 8904 has 368 specific ...
Güçlü O─čuz - - 2012
We investigated whether the maxillary sinus plays a stimulatory role in nasal nitric oxide (NO) synthesis. Research on sinusitis and nasal polyps has found low NO levels in exhaled air and linked this to obstruction of the ostium. However, the major source of NO in exhaled air is thought to ...
Chen Szu-Chia - - 2012
: Abnormal ankle-brachial index (ABI) is associated with increased morbidity and mortality in hemodialysis patients. However, whether the decrease in ABI over time carries the prognostic value is unknown. The aim of this study was to assess whether the decrease in ABI over time was a good predictor of poor ...
Rinker Brian B Department of Surgery, Division of Plastic Surgery, University of Kentucky, Lexington, Ky 40536-0284, USA. - - 2012
Acellular dermal matrices are commonly used in breast reconstruction but add cost to the procedure and have been associated with complications. Dermal autograft may represent a useful alternative to matrices. Sixteen patients (26 breasts) underwent breast reconstruction using tissue expanders and dermal autograft. Their ages ranged from 41 to 66 ...
Fallucco Michael M Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, - - 2012
Current literature for surgical deactivation of frontal migraine trigger points does not incorporate decompression of the supraorbital foramen or fascial bands at the supraorbital rim (frontal exit) as part of the surgical procedure. To evaluate this primary compression site for the supraorbital nerve, anatomical dissections were performed and a classification ...
Fagiolini Andrea - - 2012
Trazodone is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs). The drug is approved and marketed in several countries worldwide for the treatment of major depressive disorder (MDD) in adult patients. In clinical studies, trazodone has demonstrated comparable antidepressant activity to other ...
Koay Mei Hui E - - 2012
Koay M H E, Crook M & Stewart C J R (2012) Histopathology Cyclin D1, E-cadherin and beta-catenin expression in FIGO Stage IA cervical squamous carcinoma: diagnostic value and evidence for epithelial-mesenchymal transition Aims:  Immunohistochemistry is helpful in distinguishing cervical neoplastic lesions from their histological mimics, but has contributed less ...
Lorenc Z Paul ZP Lorenc Aesthetic Plastic Surgery Center, New York, NY 10028, USA. - - 2012
Soft-tissue augmentation with injectable fillers is commonly performed in the malar area. A four-point scale, the Medicis Midface Volume Scale, was developed and validated as an objective measure of the severity of midface volume loss. Using a separate photographic guide, four investigators rated photographs (front and right and left sides, ...
Giardina Andrea Susan - - 2012
To present a novel case of pupillary involvement in ocular neuromyotonia (ONM), a rare ocular syndrome that causes intermittent diplopia because of an abnormal delay in extraocular muscle relaxation and to conduct a literature review. A case report is presented to demonstrate clinical characteristics and treatment of ONM. In addition, ...
Buchanan Edward P EP Division of Plastic Surgery, Harborview Medical Center, Seattle, Wash, - - 2012
Zygomaticomaxillary complex fractures associated with ipsilateral naso-orbito-ethmoidal fractures are more complex injuries than isolated zygomaticomaxillary complex fractures. This injury pattern can have significant long-term morbidity if not recognized and treated appropriately during the initial operation. The purpose of this study is to compare mechanisms of injury, treatment, and outcome between ...
Lin Chih-Hung CH Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital and University, Taoyuan, Taiwan. - - 2012
Thumb amputations proximal to the metacarpophalangeal joint inevitably result in destruction of the thenar musculature and secondary loss of opposition. Opposable tripod pinch is one of the essential goals in toe-to-thumb reconstruction. Pronation osteosynthesis is the traditional method of restoring opposition, but a simultaneous opponensplasty may turn this static process ...
- - 2012
The American Journal of Nursing is a peer-reviewed journal. Nurses and other practitioners serve as peer reviewers, sharing with us their expertise in health care, research, and all aspects of nursing practice. They are essential to ensure the quality of the manuscripts we publish. We are pleased to acknowledge and ...
Marín-Franch Iván I Indiana University School of Optometry, Bloomington, Indiana 47405, USA. - - 2012
Measurement of retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) is commonly used in the detection and management of glaucoma. The Stratus OCT (Carl Zeiss Meditec, Inc., Dublin, CA) is widely used, but image acquisition is subject to artifacts, such as those caused by normal fixational eye ...
Bertelli Jayme A JA Department of Orthopedic Surgery, Governador Celso Ramos Hospital, Florianópolis and Tubarão, Santa Catarina, Brazil. - - 2012
In extended upper-type lesions of the brachial plexus, nerve transfers and root grafting have improved the results of shoulder and elbow reconstruction. However, wrist extension reconstruction has received little attention. In 20 cadaveric upper limbs, we dissected the anterior interosseous nerve and extensor carpi radialis brevis motor branch. Four patients ...
Waljee Jennifer F JF Section of Plastic Surgery, Department of Surgery, The University of Michigan Health System, Ann Arbor, Mich 48109-5340, USA. - - 2012
Every year, hundreds of new surgical devices and techniques are introduced, and plastic surgeons must determine the associated risks, benefits, and costs of these options when incorporating these advances into their armamentarium. This article will discuss the elements of treatment effectiveness by applying the principles of evidence-based medicine to therapeutics. ...
Liu Shuo - - 2012
To assess the ability of sclerostin antibody therapy to blunt the negative effects of polyethylene particles on implant fixation and peri-implant bone structure in a rat implant fixation model. Thirty-six adult male rats received intramedullary titanium implants; 12 rats received vehicle injections only (control), and 24 rats received intraarticular injections ...
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