Task shifting and sharing may provide one solution.

Interleukin-17 (IL-17) is considered a proinflammatory cytokine, but whether neuronal IL-17 receptors contribute to the generation of arthritic pain is unknown. This study was undertaken to explore whether IL-17A acts on neurons, whether it sensitizes joint nociceptors, and whether neutralization of IL-17 is antinociceptive. We recorded action potentials from rat ...

Serosorting, selecting sex partners of the same HIV status, may be associated with increased risk of sexually transmitted infection (STI). We examined the association between unprotected anal intercourse (UAI) with a seroconcordant partner and STIs among HIV-negative men who have sex with men (MSM) at an urban lesbian, gay, bisexual, ...

U.S. breastfeeding rates have improved, but we need to do more to support this practice.

STUDY DESIGN.: A retrospective multi-institutional study. OBJECTIVE.: To clarify the distribution of intraoperative blood loss during cervical laminoplasty for ossification of the posterior longitudinal ligament (OPLL), and to identify the radiographical risk factors for the occurrence of major blood loss in patients with OPLL undergoing laminoplasty. SUMMARY OF BACKGROUND DATA.: ...

A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.

Wickerhamomyces ciferrii is a microorganism characterized by the production and secretion of large amounts of acetylated sphingoid bases, in particular tetraacetyl phytosphingosine. Here, we present the 15.90-Mbp draft genome sequence of W. ciferrii NRRL Y-1031 F-60-10 generated by pyrosequencing and de novo assembly. The draft genome sequence comprising 364 contigs ...

Background:  The aim of the present study was to evaluate the association between HbA1c and serum fetuin-A levels in middle-aged and elderly Chinese. Methods:  A total of 3790 subjects (1519 men; 2271 women) aged ≥40 years were enrolled in this cross-sectional study in the Songnan community of Baoshan District, Shanghai, China. ...

ABSTRACT: Emergency department patients are at increased risk for infection with chlamydia and gonorrhea, but routine screening of asymptomatic patients is problematic. Limiting screening to patients answering the affirmative to 2 questions would reduce the number of tests administered by 51.9%, increase the tested population prevalence to 15.7%, and still ...

A case report and the evidence for choosing among several available drugs for this patient.

Most of the evidence regarding complications following total hip arthroplasty (THA) and total knee arthroplasty (TKA) is based on studies of patients with osteoarthritis (OA), with little being known about outcomes in patients with rheumatoid arthritis (RA). The objective of the present study was to review the current evidence regarding ...

To establish within-rater repeatability and minimum measurements required for reliable assessment of central corneal thickness (CCT) using Topcon three-dimensional OCT-2000 (Topcon Medical Systems, Oakland, NJ) Fourier-domain optical coherence tomography (FD-OCT) and to test agreement against ultrasound pachymetry (USP). Twenty participants underwent five scans using FD-OCT followed by five CCT measurements ...

: The purpose of this study was to determine the current preferences of plastic surgeons regarding preoperative assessment and their effect on clinical outcome in primary breast augmentation. : An eight-question online survey was sent to members of the American Society of Plastic Surgeons. Data collected online were analyzed using ...

Sarcopenic obesity is a body composition category in which obesity is accompanied by low skeletal muscle mass, offsetting the increase in body weight caused by increased adipose tissue. The purpose of this study was to analyze the association between knee osteoarthritis (OA) and 4 different categories of body composition: normal, ...

: The graying of our population has motivated the authors to better understand age-related impairments in wound healing. To increase research throughput, the authors hypothesized that the Hutchinson-Gilford progeria syndrome Zmpste24-deficient (Zmpste24) mouse could serve as a model of senescent wound healing. : Using a stented excisional wound closure model, ...

Trichomonas has been reported to be rare in Australia's major cities while remaining very common in some extremely remote Aboriginal communities. This study examined the Trichomonas prevalence and relationship to remoteness among patients attending sexual health clinics in rural and remote areas of New South Wales, Australia. During the period ...

Potential effect of inhaled glucocorticoids must be weighed against known benefits.

This study assessed the prevalence of convergence insufficiency (CI) with and without simultaneous vision dysfunctions within the traumatic brain injury (TBI) sample population because although CI is commonly reported with TBI, the prevalence of concurrent visual dysfunctions with CI in TBI is unknown. A retrospective analysis of 557 medical records ...

SUMMARY:: Patients presenting for plastic surgery consultation after massive weight loss require a thorough preoperative evaluation that takes into account the complex medical and psychosocial issues associated with obesity. A number of factors must be considered, including type of weight loss procedure, nutritional deficiencies, body mass index at the time ...

MicroRNAs have recently been shown to regulate the downstream bioprocesses of intracerebral hemorrhage. The aim of this study was to investigate whether miRNAs can be used as biomarkers to predict secondary hematoma enlargement (HE) in patients with ICH. Consecutively, 79 ICH patients admitted within 6 h of symptom onset and 30 ...

Major malformations, surgery and persistent pulmonary hypertension (PHT) have been considered contraindications to therapeutic hypothermia (TH) in newborns with hypoxic-ischemic encephalopathy (HIE). We report two patients with undiagnosed congenital diaphragmatic hernia (CDH) who developed HIE after birth. Diagnosis of moderate HIE was formulated based on clinical, laboratory and electroencephalographic criteria. ...

: This pilot study examined the efficacy of 5-bromo-2-deoxyuridine-labeled autologous adipose-derived stem cells seeded onto collagen scaffolds to augment and/or regenerate the fat-enriched hypodermal tissue in an acute porcine wound model. : Porcine autologous adipose-derived stem cells were isolated and cultured. At passage 2, the cells were labeled with 5-bromo-2-deoxyuridine, ...

: The longevity of face-lift surgery is a key question that has not been adequately addressed by previous studies. No study has used standardized photographs, objective measurements, or validated subjective scoring systems. : From 2001 to 2011, photographs were standardized in this institution. Fifty primary face-lift patients were assessed 5.5 ...

Undiagnosed sexually transmitted infections (STIs) may be common in the adult film industry because performers frequently engage in unprotected oral and anal intercourse, STIs are often asymptomatic, and the industry relies on urine-based testing. Between mid-May and mid-September 2010, a consecutive sample of adult film industry performers recruited from a ...

To assess the clinical effect of transplantation of human retinal pigment epithelial (hRPE) cells into the unilateral postcommissural putamen for treatment for Parkinson disease (PD). Cells from postmortem human eye tissue (10-20 weeks of gestation) were cultured in vitro. Cells from -generation passage were implanted in PD postcommissural putamen with stereotactic ...

The use of monofocal, bifocal, or multifocal intraocular lenses (IOLs) is a common option to restore the refractive power of the eye in aphakic patients after cataract surgery. In this article, we study the predicted performance of two new designs of IOL, both with extended depth of focus: the quartic ...

: Deep vein thrombosis and its most dangerous outcome, pulmonary embolism, are complications with a high incidence in hospitalized patients. In plastic surgery, abdominoplasty is the aesthetic surgery more frequently associated with deep vein thrombosis condition. This study aimed to test the efficacy and safety of oral rivaroxaban for the ...

This study utilizes sensitive, modern isothermal titration calorimetric methods to characterize the microscopic thermodynamic parameters that drive the binding of basic drugs to α-1-acid glycoprotein (AGP) and thereby rationalize the thermodynamic data in relation to docking models and crystallographic structures of the drug-AGP complexes. The binding of basic compounds from ...

A herbal drug combination (Dry Extract BNO 1016) has been assessed for efficacy and tolerability in patients with acute viral rhinosinusitis. In this randomised, controlled trial patients with symptom duration of up to 3 days, mild to moderate facial pain and a Major Symptom Score (MSS) between 8 and 12 ...

: Application of platelet concentrates to wounds could speed healing. Leukocyte- and platelet-rich fibrin, a relatively recent development, stands out from the other preparations. This prospective, randomized, controlled clinical trial studied the rate of healing of postoperative hand wounds after a single application of leukocyte- and platelet-rich fibrin. : Eligible ...

ABSTRACT: Serum specimens collected during the 2011 round of National HIV Behavioral Surveillance among men who have sex with men in San Francisco were tested for hepatitis C virus antibodies. Hepatitis C virus infection was found among men who have sex with men with a history of intravenous drug use ...

This is the third and final article in a three-part series on nursing boards' disciplinary actions and what nurses need to know to maintain their license in good standing. This article discusses strategies for protecting your license.

: Plastic surgeons often approach nasal aesthetic evaluation with the aid of seemingly objective measurements. However, ideal measurements of an attractive nose, as suggested in the literature, might not apply on a cross-cultural basis. Given these controversies, this study aimed to investigate the cultural and ethnic impact on nasal shape ...

: Viral nosocomial infections (NIs) in children are common and most frequently affect the gastrointestinal or respiratory tract. Few studies are dedicated to this topic. We aimed to determine incidence and characteristics of these specific viral NIs at our hospital. : This was a retrospective analysis of nosocomial gastroenteritis and ...

: Although a multitude of proposed forehead rejuvenation procedures have been described, long-term and systematic morphometric evaluation is rare. There are no studies comparing endoscopic forehead lifts and transpalpebral browpexy techniques according to their efficacy in raising and reshaping the brow. : In a retrospective study, standardized photographic documentations of ...

: Free tissue transfer to improve bulk and contour in facial deformities has been proven useful, yet refinements that turn an acceptable result into an excellent result are essential to reconstruction. The authors reviewed their experience and described these refinements. : The charts of 371 free tissue transfer cases (1989 ...

: Increasing focus on reducing morbidity from latissimus dorsi flaps has led to the evolution of muscle-sparing variants and perforator-based flaps. This study aimed to investigate the vascular anatomy of the muscle-sparing variant and to describe its application as a free flap based on the descending branch of the thoracodorsal ...

The extensive study presented by Toma and coworkers is one of the first presenting normative three-dimensional soft tissue face data derived from a large group of 15-year-old Caucasians using laser surface scanning. This data is not only important to quantify facial variation in a normal population but can help to ...

According to biochemical assays, the Bcl-2 protein Diva from mouse regulates programmed cell death by heterodimerizing with other members of the family and by interacting with the apoptotic protease-activating factor Apaf-1. In typical Bcl-2 heterodimers, peptide fragments comprising the Bcl-2 homology domain 3 (BH3 domain) of proapoptotic members are capable ...

People who become patients in secure hospitals may not understand their situation and have different opinions about the nature of institutionalisation from each other and from staff and the authorities. More knowledge of patient perspectives could improve treatment outcomes. Our aim was to evaluate patients' beliefs about whether placement in ...

Getting past "We've always done it this way" is crucial.

An exploration of bias in health care and how it affects this population.

To identify the optical needs of students with low vision studying in the integrated schools for the blind in Nepal. A total of 779 blind and vision-impaired students studying in 67 integrated schools for the blind across Nepal were examined using the World Health Organization/Prevention of Blindness Eye Examination Record ...

: The most untoward aspect of the anterolateral thigh is the complexity of the local vasculature. Failure to understand its variability can lead to vascular flap embarrassment and tissue loss. The authors present a comprehensive summary of the vascular anatomy of the anterolateral thigh. : A MEDLINE search was performed ...

: Secondary rhytidectomy procedures present an additional level of complexity in comparison with primary procedures. Patients may seek secondary rhytidectomy, in part, as a result of complications stemming from the initial procedure, because of the natural process of aging, or a combination of the two. The aim of this literature ...

A lectin from seeds of Dioclea lasiocarpa (DLL) was purified in a single step by affinity chromatography in a Sephadex G-50 column. DLL haemagglutinated rabbit erythrocytes showing stability even after 1 h of exposure to a different pH values (optimal between pH 6.0 and 8.0) but was inhibited after incubation with ...

In Bangladesh, male clients (MCs) of female sex workers (FSWs) represent diverse occupational categories from different socioeconomic strata, and they are considered a bridging group to transmit sexually transmitted infections (STIs) to their spousal and nonspousal female partners. This study aimed to better understand sexual behaviors, STI symptoms, and care-seeking ...

The American Journal of Nursing is a peer-reviewed journal. Nurses and other practitioners serve as peer reviewers, sharing with us their expertise in health care, research, and all aspects of nursing practice. They are essential to ensure the quality of the manuscripts we publish. We are pleased to acknowledge and ...

ABSTRACT: Measurement of retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) is commonly used in the detection and management of glaucoma. The Stratus OCT (Carl Zeiss Meditec, Inc., Dublin, CA) is widely used, but image acquisition is subject to artifacts, such as those caused by normal fixational ...

: In extended upper-type lesions of the brachial plexus, nerve transfers and root grafting have improved the results of shoulder and elbow reconstruction. However, wrist extension reconstruction has received little attention. : In 20 cadaveric upper limbs, we dissected the anterior interosseous nerve and extensor carpi radialis brevis motor branch. ...