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Hall David W - - 2013
We explore the evolutionary origins of dosage compensation (DC) in sex chromosomes in the context of metabolic control theory. We consider first the cost of gene loss (hemizygosity) per se in reducing flux, and examine two relationships between flux and fitness (linear and Gaussian) to calculate a fitness cost of ...
Chandarana Hersh H Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, NY, USA. - - 2013
The objectives of this study were to develop a new method for free-breathing contrast-enhanced multiphase liver magnetic resonance imaging (MRI) using a combination of compressed sensing, parallel imaging, and radial k-space sampling and to demonstrate the feasibility of this method by performing image quality comparison with breath-hold cartesian T1-weighted (conventional) ...
Atkins Harold L HL Ottawa Hospital Research Institute, Ottawa, Canada. - - 2013
Reports from more than 600 hematopoietic stem cell transplants (HSCT) have appeared in the medical literature for the last 1 and one-half decades. The patient's own stem cells are harvested and stored temporarily while high doses of chemotherapy and biologics are used to destroy the auto-destructive immune system. The immune ...
Karp Peter D PD Bioinformatics Research Group, SRI International, Menlo Park, CA, USA. - - 2013
Pathway databases collect the bioreactions and molecular interactions that define the processes of life. The MetaCyc family of pathway databases consists of thousands of databases that were derived through computational inference of metabolic pathways from the MetaCyc pathway/genome database (PGDB). In some cases, these DBs underwent subsequent manual curation. Curated ...
Diekman Brian O BO Department of Orthopaedic Surgery, Duke University Medical Center and Duke University, Durham, North Carolina, 27710, - - 2013
Regenerative medicine offers the exciting potential of developing alternatives to total joint replacement for treating osteoarthritis. In this article, we highlight recent work that addresses key challenges of stem cell-based therapies for osteoarthritis and provide examples of innovative ways in which stem cells can aid in the treatment of osteoarthritis. ...
Chow April M AM Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR, - - 2013
Cyclic decapeptide CGLIIQKNEC (CLT1) has been demonstrated to target fibronectin-fibrin complexes in the extracellular matrix of different tumors and tissue lesions. Although liver fibrosis is characterized by an increased amount of extracellular matrix consisting of fibril-forming collagens and matrix glycoconjugates such as fibronectin, we aimed to investigate the feasibility of ...
Parpura Vladimir V Department of Neurobiology, Center for Glial Biology in Medicine, Atomic Force Microscopy and Nanotechnology Laboratories, Civitan International Research Center, Evelyn F. McKnight Brain Institute, University of Alabama, Birmingham, AL 35294, USA. - - 2013
The brain operates through complex interactions in the flow of information and signal processing within neural networks. The 'wiring' of such networks, being neuronal or glial, can physically and/or functionally go rogue in various pathological states. Neuromodulation, as a multidisciplinary venture, attempts to correct such faulty nets. In this review, ...
Boado Ruben J RJ ArmaGen Technologies, Inc., Santa Monica, CA 90401, - - 2013
Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder of the brain caused by mutations in the gene encoding the lysosomal sulfatase, arylsulfatase A (ASA). It is not possible to treat the brain in MLD with recombinant ASA, because the enzyme does not cross the blood-brain barrier (BBB). In the present ...
Wilkinson A V AV Division of Epidemiology, Human Genetics and Environmental Science, University of Texas School of Public Health, Austin Regional Campus, Austin, TX 78701, USA. - - 2013
Many studies examining genetic influences on physical activity (PA) have evaluated the impact of single nucleotide polymorphisms (SNPs) related to the development of lifestyle-related chronic diseases, under the hypothesis that they would be associated with PA. However, PA is a multidetermined behavior and associated with a multitude of health consequences. ...
Zhong Lina L Department of Chemical Engineering, The Grove School of Engineering, The City College of New York, 140th Street at Convent Avenue, New York, New York 10031, United - - 2013
The strict requirement of constructing a native lipid environment to preserve the structure and functionality of membrane proteins is the starting constraint when building biomaterials and sensor systems from these biomolecules. To enhance the viability of supported biomembranes systems and build new ligand display interfaces, we apply rationally designed peptides ...
Perkins Timothy T - - 2013
OmpR is a multifunctional DNA binding regulator with orthologues in many enteric bacteria that exhibits classical regulator activity as well as nucleoid-associated protein-like characteristics. In the enteric pathogen Salmonella enterica, using chromatin immunoprecipitation of OmpR:FLAG and nucleotide sequencing, 43 putative OmpR binding sites were identified in S. enterica serovar Typhi, 22 ...
Guttenplan Sarah B SB Department of Biology, Indiana University, Bloomington, IN 47405, - - 2013
Bacterial flagella are highly conserved molecular machines that have been extensively studied for assembly, function and gene regulation. Less studied is how and why bacteria differ based on the number and arrangement of the flagella they synthesize. Here we explore the cell biology of peritrichous flagella in the model bacterium ...
Saint Clair Erica C EC Department of Physics, Photonics Center and Molecular Biophysics Laboratory, Boston University, Boston, Massachusetts 02215, - - 2012
Archaerhodopsin 3 (AR3) is a light driven proton pump from Halorubrum sodomense that has been used as a genetically targetable neuronal silencer and an effective fluorescent sensor of transmembrane potential. Unlike the more extensively studied bacteriorhodopsin (BR) from Halobacterium salinarum, AR3 readily incorporates into the plasma membrane of both E. ...
Bubunenko Mikhail M Frederick National Laboratory for Cancer Research, Basic Research Program, SAIC-Frederick, Inc., Frederick, MD 21702, - - 2013
Escherichia coli NusA and NusB proteins bind specific sites, such as those in the leader and spacer sequences that flank the 16S region of the ribosomal RNA transcript, forming a complex with RNA polymerase that suppresses Rho-dependent transcription termination. Although antitermination has long been the accepted role for Nus factors ...
Ibrahim Diaa A DA National Organization for Drug Control & Research, Cairo, Gizaa, - - 2012
Tuberculosis (TB) is a global health threat with nearly 500 000 new cases of multidrug-resistant TB estimated to occur every year, so new drugs are desperately needed. A number of current antimycobacterial drugs work by interfering with the biosynthesis of key components of the mycolylarabinogalactan (mAG). In light of this ...
Ellis Katie E KE Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, - - 2012
All known active forms of diheme bacterial cytochrome c peroxidase (bCcP) enzymes are described by a homodimeric state. Further, the majority of bCcPs reported display activity only when the high-potential electron transfer heme of the protein (Fe(H)) is reduced to the ferrous oxidation state. Reduction of Fe(H) results in a ...
Creutz Carl E CE Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA. - - 2012
Biological membranes are exposed to a number of chemical and physical stresses that may alter the structure of the lipid bilayer in such a way that the permeability barrier to hydrophilic molecules and ions is degraded. These stresses include amphiphilic molecules involved in metabolism and signaling, highly charged polyamines, membrane-permeating ...
Pei Yanzhong - - 2012
Thermoelectric generators have been used for powering spacecrafts since the 1950s. Low material efficiency limits its application on a large scale. On page 6125, G. J. Snyder, Yanzhong Pei, and Heng Wang review strategies of engineering the electronic band structure, such as effective mass, degeneracy and band gap, which increase ...
Wen Liping - - 2012
An efficient and reversible ionic gating that can be activated by pH and light is demonstrated on page 6193 by Lei Jiang, Zhishan Bo, and co-workers, by modifying a malachite green derivative on the interior surface of an ion track-etched conical nanochannel. The switches between the OFF-state and the ON-state ...
Gushwa Nathan N NN Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94158, United - - 2012
Src-family tyrosine kinases play pivotal roles in human physiology and disease, and several drugs that target members of this family are in clinical use. None of these drugs appear to discriminate among closely related kinases. However, assessing their selectivity toward endogenous kinases in living cells remains a significant challenge. Here, ...
Zheng Jing J Molecular Science and Biomedicine Laboratory, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, 410082, - - 2012
A DNA configuration switch is designed to fabricate a reversible and regenerable Raman-active substrate. The substrate is composed of a Au film and a hairpin-shaped DNA strand (hot-spot-generation probes, HSGPs) labeled with dye-functionalized silver nanoparticles (AgNPs). Another ssDNA that recognizes a specific trigger is used as an antenna. The HSGPs ...
Shalek Alex K AK Department of Chemistry, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United - - 2012
A circuit level understanding of immune cells and hematological cancers has been severely impeded by a lack of techniques that enable intracellular perturbation without significantly altering cell viability and function. Here, we demonstrate that vertical silicon nanowires (NWs) enable gene-specific manipulation of diverse murine and human immune cells with negligible ...
Koay Mei Hui E - - 2012
Koay M H E, Crook M & Stewart C J R (2012) Histopathology Cyclin D1, E-cadherin and beta-catenin expression in FIGO Stage IA cervical squamous carcinoma: diagnostic value and evidence for epithelial-mesenchymal transition Aims:  Immunohistochemistry is helpful in distinguishing cervical neoplastic lesions from their histological mimics, but has contributed less ...
Lorenc Z Paul - - 2012
: Soft-tissue augmentation with injectable fillers is commonly performed in the malar area. A four-point scale, the Medicis Midface Volume Scale, was developed and validated as an objective measure of the severity of midface volume loss. : Using a separate photographic guide, four investigators rated photographs (front and right and ...
Giardina Andrea Susan - - 2012
To present a novel case of pupillary involvement in ocular neuromyotonia (ONM), a rare ocular syndrome that causes intermittent diplopia because of an abnormal delay in extraocular muscle relaxation and to conduct a literature review. A case report is presented to demonstrate clinical characteristics and treatment of ONM. In addition, ...
Buchanan Edward P - - 2012
: Zygomaticomaxillary complex fractures associated with ipsilateral naso-orbito-ethmoidal fractures are more complex injuries than isolated zygomaticomaxillary complex fractures. This injury pattern can have significant long-term morbidity if not recognized and treated appropriately during the initial operation. The purpose of this study is to compare mechanisms of injury, treatment, and outcome ...
Lin Chih-Hung - - 2012
: Thumb amputations proximal to the metacarpophalangeal joint inevitably result in destruction of the thenar musculature and secondary loss of opposition. Opposable tripod pinch is one of the essential goals in toe-to-thumb reconstruction. Pronation osteosynthesis is the traditional method of restoring opposition, but a simultaneous opponensplasty may turn this static ...
Wang Xin - - 2012
Coronary heart disease (CHD) is characterized by inflammatory process and endothelial dysfunction. To investigate angiopoietin-2 (Ang-2) profiles, we evaluated serum Ang-2 levels in different types of CHD in 166 subjects. Ang-2 was measured by enzyme-linked immunosorbent assay. Serum Ang-2 levels were significantly elevated in patients with CHD and gradually increased ...
Wang Yuanyuan - - 2012
Although there is evidence for a beneficial effect of increased quadriceps strength on knee symptoms, the effect on knee structure is unclear. We undertook this study to examine the relationship between change in vastus medialis cross-sectional area (CSA) and knee pain, tibial cartilage volume, and risk of knee replacement in ...
Wikström Erika - - 2012
In recent decades, increasing rates of Chlamydia cases have contrasted with decreasing Chlamydia trachomatis seroprevalence rates and decreasing Chlamydia-associated complication rates. We elucidated the conflicting trends by studying incidence of repeated Chlamydia infections over time. Chlamydia cases reported during 1995 to 2009 were identified in the Finnish National Infectious Diseases ...
Shi Guohua - - 2012
ABSTRACT. In order to understand the relationship between accommodation and vision quality, a custom-built ultra-long scan depth spectral domain optical coherence tomography (UL-SDOCT) and a Shack-Hartmann wavefront sensor (HSWFS) were combined. The resolution and scan depth of UL-SDOCT are 6 μm and 15.6 mm, respectively, which allow for high-resolution imaging of the ...
Javanbakht Marjan - - 2012
The prevalence and correlates of rectal sexually transmitted infections are well described among men who report receptive anal intercourse (AI); however, little is known about the epidemiology of rectal sexually transmitted infections among women. We conducted a cross-sectional study of women attending public sexually transmitted disease clinics in Los Angeles ...
Potera Carol - - 2012
'Near-time' readings aren't as accurate and could lead to harm.
Chen Szu-Chia - - 2012
: Abnormal ankle-brachial index (ABI) is associated with increased morbidity and mortality in hemodialysis patients. However, whether the decrease in ABI over time carries the prognostic value is unknown. The aim of this study was to assess whether the decrease in ABI over time was a good predictor of poor ...
Liu Shuo - - 2012
To assess the ability of sclerostin antibody therapy to blunt the negative effects of polyethylene particles on implant fixation and peri-implant bone structure in a rat implant fixation model. Thirty-six adult male rats received intramedullary titanium implants; 12 rats received vehicle injections only (control), and 24 rats received intraarticular injections ...
Liu Mengyuan T - - 2012
: Müller's muscle-conjunctival resection is used to correct mild to moderate ptosis commonly encountered in the rejuvenation patient population. The authors examined its efficacy and analyzed variables that potentially affect outcomes. : Patients who underwent ptosis correction using Müller's muscle-conjunctival resection with greater than 10-month follow-up were included. Amount of ...
Anderson Deborah J - - 2012
Self-administered swabs are used to sample vaginal contents for a variety of clinical purposes including detection of sexually transmitted infections, condom breakage, and vaginal product use. The goal of this study was to determine whether a quantitative glycogen assay can be used to assess whether a swab has been exposed ...
Park Joo Hyun - - 2012
: The authors present the senior author's experience and evolution of techniques with the use of autologous costal cartilage grafts in Asian rhinoplasty. : Eighty-three patients who had rhinoseptoplasty with autologous costal cartilage grafts were included in this retrospective review. The types of grafts, complications related to the graft itself ...
Farinelli C K - - 2012
OBJECTIVE: To evaluate whether increasing body mass index (BMI) alters the efficacy of ultrasound-directed cerclage in women with a history of preterm birth. METHODS: This was a planned secondary analysis of a multicenter trial in which women with a singleton gestation and prior spontaneous preterm birth (17 to 33 + ...
Martone Gerald - - 2012
One of the world's worst refugee crises revisited.
Nakai Shigeru - - 2012
A nationwide statistical survey of 4226 dialysis facilities was conducted at the end of 2010, and 4166 facilities (98.6%) responded. The number of new patients introduced into dialysis was 37 512 in 2010. This number has decreased for two consecutive years since it peaked in 2008. The number of patients who ...
Sims Traci T - - 2012
An innovative program for recruiting nurses in the psychiatric setting.
Li Lirong - - 2012
Type 1 diabetes is characterized pathologically by autoimmune insulitis-related islet β-cell destruction. Although intensive insulin therapy for patients with type 1 diabetes can correct hyperglycemia, this therapy does not prevent all diabetes-related complications. Recent studies have shown that autologous hematopoietic stem cell transplantation (HSCT) is a promising new approach for ...
Zhao Jin - - 2012
HIV transmission among men who have sex with men (MSM) has become an increasing concern in China. Money boys (MBs) are a subgroup of MSM who sell sex to men. Direct comparison of HIV prevalence and related risk factors between MB and noncommercial MSM (ncMSM) has rarely been done. This ...
Nelson Roxanne - - 2012
Task shifting and sharing may provide one solution.
Richter Frank - - 2012
Interleukin-17 (IL-17) is considered a proinflammatory cytokine, but whether neuronal IL-17 receptors contribute to the generation of arthritic pain is unknown. This study was undertaken to explore whether IL-17A acts on neurons, whether it sensitizes joint nociceptors, and whether neutralization of IL-17 is antinociceptive. We recorded action potentials from rat ...
Hotton Anna L - - 2012
Serosorting, selecting sex partners of the same HIV status, may be associated with increased risk of sexually transmitted infection (STI). We examined the association between unprotected anal intercourse (UAI) with a seroconcordant partner and STIs among HIV-negative men who have sex with men (MSM) at an urban lesbian, gay, bisexual, ...
Wells Courtenay A - - 2012
U.S. breastfeeding rates have improved, but we need to do more to support this practice.
Kato So - - 2012
STUDY DESIGN.: A retrospective multi-institutional study. OBJECTIVE.: To clarify the distribution of intraoperative blood loss during cervical laminoplasty for ossification of the posterior longitudinal ligament (OPLL), and to identify the radiographical risk factors for the occurrence of major blood loss in patients with OPLL undergoing laminoplasty. SUMMARY OF BACKGROUND DATA.: ...
Liu Yu - - 2012
Background:  The aim of the present study was to evaluate the association between HbA1c and serum fetuin-A levels in middle-aged and elderly Chinese. Methods:  A total of 3790 subjects (1519 men; 2271 women) aged ≥40 years were enrolled in this cross-sectional study in the Songnan community of Baoshan District, Shanghai, China. ...
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