Search Results
Results 701 - 750 of 2474
< 10 11 12 13 14 15 16 17 18 19 20 >
Huang Jin - - 2012
Novel block copolymers comprising poly(ethylene glycol) (PEG) and a oligo(tyrosine) block were synthesized in different compositions by N-carboxyanhydride (NCA) polymerization. It was shown that PEG2000-Tyr6 undergoes thermoresponsive hydrogelation at a low concentration range of 0.25-3.0 wt% within a temperature range of 25 to 50°C. Cryogenic Transmission Electron Microscopy (Cryo-TEM) revealed ...
Li Zhenglun - - 2012
Copper(II) 2,2'-bipyridine (Cu(II) (bpy))-catalyzed alkaline hydrogen peroxide (AHP) pretreatment was performed on three biomass feedstocks including alkali pre-extracted switchgrass, silver birch, and a hybrid poplar cultivar. This catalytic approach was found to improve the subsequent enzymatic hydrolysis of plant cell wall polysaccharides to monosaccharides for all biomass types at alkaline ...
Esteban Pedro F - - 2012
The protein anosmin-1, coded by the KAL1 gene responsible for the X-linked form of Kallmann syndrome (KS), exerts its biological effects mainly through the interaction with and signal modulation of fibroblast growth factor receptor 1 (FGFR1). We have previously shown the interaction of the third fibronectin-like type 3 (FnIII) domain ...
Yasui Fumihiko - - 2012
The influence of the intracellular redox state on the hepatitis C virus (HCV) life cycle is poorly understood. This study demonstrated the anti-HCV activity of 2,3-dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran (BO-653), a synthetic lipophilic antioxidant, and examined whether BO-653's antioxidant activity is integral to its anti-HCV activity. The anti-HCV activity of BO-653 was investigated ...
Leung Ken Cham-Fai - - 2012
Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8-10 nm), circular plasmid DNA (∼4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.
Maggio Emanuele - - 2012
Suitably designed symmetric dyes can be used in dye-sensitized solar cells to reduce the charge recombination rate by two to three orders of magnitude. If the electron coupling between the electrode and the dye is mediated by a conjugated linker, it is possible to design dyes for which the HOMO ...
Galeano Carolina - - 2012
The durability of electrode materials is a limiting parameter for many electrochemical energy conversion systems. In particular, electrocatalysts for the essential oxygen reduction reaction (ORR) present some of the most challenging instability issues shortening their practical lifetime. Here we report a mesostructured graphitic carbon support - Hollow Graphitic Spheres (HGS) ...
Monaghan Brenda - - 2012
ABSTRACT: BACKGROUND: Prolonged physical impairments in range of movement, postural stability and walking speed are commonly reported following total hip replacement (THR). It is unclear from the current body of evidence what kind of exercises should be performed to maximize patient function and quality of life.Methods/designThis will be a single ...
Li Na - - 2012
Corilagin is a member of polyphenolic tannins. Its antimicrobial activity and action mechanism against Escherichia coli, Staphylococcus aureus and Candida albicans were investigated through membrane permeability. Crystal violet staining determination, outer membrane (OM) and inner membrane (IM) permeability, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and atomic force microscopy (AFM) ...
Hassinen Antti - - 2012
The effect of short chain alcohols and acetonitrile on the ligand shell composition and the photoluminescence quantum yield of purified PbSe and CdSe quantum dots is analyzed by solution NMR and photoluminescence spectroscopy. We find that short chain alcohols induce the release of X-type carboxylate ligands with a concurrent reduction ...
Moon Hoi Ri - - 2012
In this review, we highlight various preparative strategies and characterization methods for metal nanoparticles fabricated in porous metal-organic frameworks (MOFs) or porous coordination polymers (PCPs), and their applications in hydrogen storage and heterogeneous catalysis.
Yoo Yeong Du - - 2012
Few protistan grazers feed on toxic dinoflagellates, and low grazing pressure on toxic dinoflagellates allows these dinoflagellates to form red-tide patches. We explored the feeding ecology of the newly described heterotrophic dinoflagellate Gyrodinium moestrupii when it fed on toxic strains of Alexandrium minutum, Alexandrium tamarense, and Karenia brevis and on ...
Uchiyama Takako - - 2012
Our knowledge is limited regarding mechanisms by which transposable elements control host gene expression. Two Antirrhinum lines, HAM2 and HAM5, show different petal colors, pale-red and white, respectively, although these lines contain the same insertion of transposon Tam3 in the promoter region of the nivea (niv) locus encoding chalcone synthase. ...
Brittain Harry G - - 2012
Solid crystalline phases containing two cocrystallized components offer a new development pathway whereby one can potentially improve the physical characteristics (i.e., equilibrium solubility, dissolution rate, solid-state stability, etc.) of a drug substance that exhibits a profile that is less than desirable. In this commentary, the topic of pharmaceutical cocrystals will ...
Broad John - - 2012
BACKGROUND AND PURPOSE: The antibiotic azithromycin is a suggested alternative to erythromycin for treating patients with delayed gastric emptying. However, although hypothesized to activate motilin receptors, supportive evidence is unavailable. This was investigated using recombinant and naturally-expressed motilin receptors in human stomach, comparing azithromycin with erythromycin. EXPERIMENTAL APPROACH: [(125) I]-motilin ...
Vo Phuong - - 2012
Background. Overweight, obesity, and asthma are more prevalent in minority children; yet, the association of overweight and obesity with spirometric values in asthmatic minorities is not well characterized. Objective. To study the relationship between weight, ethnicity, and spirometric values in children referred for asthma evaluation to a large inner-city hospital ...
Chen Kexian - - 2012
N,N-dihydroxypyromellitimide (NDHPI) and N,N',N''-trihydroxyisocyanuric acid (THICA) have been recently demonstrated to act as better carbon-radical-producing catalysts than the popular N-hydroxyphthalimide (NHPI). To gain a mature understanding of these particular catalysts, herein their geometrical, electronic, and thermochemical properties, as well as their catalytic activities, have been systemically investigated by a theoretical ...
He Jianyu - - 2012
Uncaria rhynchophylla is a traditional Chinese medicinal herb used to treat hypertension and convulsive disorders such as epilepsy. Rat prostate cell membrane chromatography combined with liquid chromatography-mass spectrometry (LC-MS) was used to identify active constituents from U. rhynchophylla extracts. Four compounds (corynoxeine, isorhynchophylline, isocorynoxeine and rhynchophylline) were discovered. Competitive binding ...
Li Wenjun - - 2012
A new efficient enantioselective conjugate addition strategy has been disclosed to rapidly construct 2-amino-3-nitrile-chromene complexes via a multi-hydrogen-bond cooperative activation model.
Wilson A - - 2012
BACKGROUND: Methotrexate (MTX) is administered subcutaneously to Crohn's Disease (CD) patients. There are very few studies evaluating the use of oral (PO) MTX in CD. A drug and its pharmaceutical alternative are equivalent (bioequivalence) when the bioavailability of the alternative falls within 80-125% of the bioavailability of the standard (US ...
Ojiambo Peter Sande - - 2012
Cucurbit downy mildew caused by Pseudoperonospora cubensis is economically the most important disease of cucurbits globally and the pathogen is disseminated aerially over a large spatial scale. Spatio-temporal spread of the disease was characterized during phase I (low and sporadic disease outbreaks) and II (rapid increase in disease outbreaks) of ...
Damianidou Labrini - - 2012
INTRODUCTION: Obstructive sleep apnea syndrome (OSAS) is a common disease that is increasingly recognized among pediatric population. The exercise capacity of adults with OSAS has been demonstrated to be impaired, but there are no data about pediatric exercise response. AIM: The aim of this study was to evaluate cardiopulmonary response ...
Chanson Jean-Baptiste - - 2012
The detection of reactivity against autoantigens plays a crucial role in the diagnosis of autoimmune diseases. However, only a few autoantibodies are known in each disease, and their precise targets are often not precisely defined. In neuromyelitis optica (NMO), an autoimmune disease of the central nervous system, anti-aquaporin 4 antibodies ...
Vallette Sophie - - 2012
OBJECTIVE: To evaluate demographic data and quality of care of patients with acromegaly in Canada and their evolution over time and secondly, to evaluate predictors of co-morbidities and treatment outcomes. DESIGN AND PATIENTS: Retrospective analyses of clinical, biochemical and treatment outcome data of 649 patients with acromegaly (males: 50.7%) followed ...
Creutz Carl Eugene - - 2012
Biological membranes are exposed to a number of chemical and physical stresses that may alter the structure of the lipid bilayer in such a way that the permeability barrier to hydrophilic molecules and ions is degraded. These stresses include amphiphilic molecules involved in metabolism and signaling, highly charged polyamines, membrane ...
Harrisson Katherine A - - 2012
Understanding how habitat fragmentation affects population processes (e.g. dispersal) at different spatial scales is of critical importance to conservation. We assessed the effects of habitat fragmentation on dispersal and regional and fine-scale population structure in a currently widespread and common cooperatively breeding bird species found across south-eastern Australia, the superb ...
Thomassen Yvonne E - - 2012
The anticipated increase in the demand for inactivated polio vaccines resulting from the success in the polio eradication program requires an increase in production capacity and cost price reduction of the current inactivated polio vaccine production processes. Improvement of existing production processes is necessary as the initial process development has ...
Theys Tom - - 2012
Depth information is necessary for adjusting the hand to the three-dimensional (3-D) shape of an object to grasp it. The transformation of visual information into appropriate distal motor commands is critically dependent on the anterior intraparietal area (AIP) and the ventral premotor cortex (area F5), particularly the F5p sector. Recent ...
Tulipani Sara - - 2012
Blood sample preparation before LC-MS metabolomic fingerprinting is one of the most challenging and error-prone part of the analytical procedure. Besides proteins, phospholipids contained in blood fluids are known to cause matrix effects and ion suppression phenomena, thus masking biological variation. Nevertheless, the commonly used sample preparation techniques do not ...
Zhang Jieyu - - 2012
Direct current (DC) stimulation has been used to promote bone repair and osteogenesis, but problems associated with the implanted metal electrodes may limit its application and compromise the therapeutic results. The replacement of the metal electrodes with a biodegradable conductive polymer film can potentially overcome these problems. In our work, ...
Kim John J - - 2012
Drug resistance is a major limitation to the successful treatment of advanced prostate cancer (PCa). Patients who have metastatic, castration-resistant PCa (mCRPC) are treated with chemotherapeutics. However, these standard therapy modalities culminate in the development of resistance. We established paclitaxel resistance in a classic, androgen-insensitive mCRPC cell line (DU145) and, ...
Coyral-Castel S - - 2012
Improvement of reproduction in dairy cows has become a major challenge in dairy production. We have recently shown that dairy cows carrying the 'fertil-' haplotype for one quantitative trait locus (QTL), affecting female fertility and located on the bovine chromosome 3, had a significantly lower conception rate after the first ...
Schel Anne Marijke - - 2012
Chimpanzees are highly territorial and have the potential to be extremely aggressive toward unfamiliar individuals. In the wild, transfer between groups is almost exclusively completed by nulliparous females, yet in captivity there is often a need to introduce and integrate a range of individuals, including adult males. We describe the ...
Wei Wei - - 2012
N-myc downstream regulated gene 1 (NDRG1/Cap43/Drg-1) has previously been shown to be dysregulated in esophageal squamous cell carcinoma (ESCC). In this study, we investigated the role of NDRG1 in the neoplastic progression of ESCC using ectopic gain-of-function and loss-of-function approaches. Stable transfectants of the KYSE30 ESCC cell line with altered ...
Ramin Michaël - - 2012
Novel urea coupling agent possessing a vinyl-terminal group and trimethoxysilyl anchoring group was synthesized and grafted onto SiO2/Au substrates. This ureido coupling agent exhibits a good capacity to directly yield homogeneous SAMs with a surface smoothing. Polarization Modulation InfraRed Reflection-Absorption Spectroscopy (PM-IRRAS) was used to monitor these SAMs since the ...
Wu Yiman - - 2012
For mass spectrometry (MS)-based metabolomics, it is important to use the same amount of starting materials from each sample to compare the metabolome changes in two or more comparative samples. Unfortunately, for biological samples, the total amount or concentration of metabolites is difficult to determine. In this work, we report ...
Caudwell Phillipa - - 2012
BACKGROUND: There are strong logical reasons why energy expended in metabolism should influence the energy acquired in food-intake behavior. However, the relation has never been established, and it is not known why certain people experience hunger in the presence of large amounts of body energy. OBJECTIVE: We investigated the effect ...
Heininger Ulrich - - 2012
Pandemic influenza A/H1N1 (piA) caused significant morbidity and mortality worldwide. We compared characteristics of piA (2009/10) to those of seasonal influenza A (siA; 2007/08/09) in 134 (piA/siA: N=55/79) hospitalized patients <18 years of age. Chronic disease was present in 25%/33%. Most common symptoms were fever (87%/94%), cough (78%/86%), rhinitis (76%/76%) ...
Rosenthal Dorothy L - - 2012
BACKGROUND: The most important indicator for urologic surgeons at The Johns Hopkins Hospital to have a patient undergo cystoscopy is a cytologic diagnosis of high-grade urothelial carcinoma. The template was designed to standardize diagnostic categories so clinicians can manage their patients uniformly. The template was based in part on the ...
Guo Caixia - - 2012
Aims:  This study aims to assess the removal mechanism of patulin using heat-treated Saccharomyces cerevisiae cells and identify the role of different cell wall components in the binding process. Methods and Results:  In order to understand the binding mechanism, viable cells, heat-treated cells, cell wall and intracellular extract were performed ...
Yagi Haruyo - - 2012
Human mesenchymal stem cells (hMSCs) are considered a highly promising candidate cell type for cell-based tissue engineering and regeneration because of their self-renewal and multi-lineage differentiation characteristics. Increased levels of reactive oxygen /nitrogen species (ROS/ RNS) are associated with tissue injury and inflammation, impact a number of cellular processes, including ...
Chamorro Julián G - - 2012
BACKGROUND AND AIM: Treatment with anti-tuberculosis (TB) drugs produces liver damage in a large proportion of patients. Isoniazid, an antibacterial drug, is primarily responsible for this hepatotoxicity. Several polymorphisms of the N-acetyltransferase 2 (NAT-2) and cytochrome P450 2E1 (CYP2E1) enzymes, which are involved in the metabolism of isoniazid, may be ...
Ortega Hector - - 2012
Rationale. Asthma exacerbations are influenced by multiple factors including environmental exposures, psychosocial interactions, and genetic variations. Aim. To better understand the correlation between clinical, physiologic, genetic, and psychological dimensions in asthma phenotypes and exacerbations. Methods. Supervised cluster analysis of a previously conducted clinical trial of asthma was used to identify ...
Casey R A - - 2012
Aggression between dogs is common and can result in injury. The aims of this study were to estimate prevalence, evaluate co-occurrence with human-directed aggression, and investigate potential risk factors, using a cross-sectional convenience sample of dog owners. Aggression (barking, lunging, growling or biting) towards unfamiliar dogs was reported to currently ...
Deshpande Abhishek - - 2012
BACKGROUND AND AIM: Proton pump inhibitors (PPI) and H(2) -receptor antagonists (H(2) RA) are frequently prescribed in hospitalized patients with cirrhosis. There are conflicting reports regarding the role of acid suppressive therapy in predisposing hospitalized patients with cirrhosis to spontaneous bacterial peritonitis (SBP).The aim of this meta-analysis was to evaluate ...
Saunders Colleen J - - 2012
The TNC gene has previously been associated with Achilles tendinopathy (AT) in a South African population. The aims of this study were (i) to investigate the association of single nucleotide polymorphisms within the TNC gene, and the additional candidate gene, COL27A1, with AT in two populations, and (ii) to identify ...
Cai Kunpeng - - 2012
With a theoretical capacity of 1,166 mAhg(-1), lithium sulfide (Li(2)S) has received much attention as a promising cathode material for high energy lithium/sulfur cells. However, the insulating nature of Li(2)S prevents the achievement of high utilization (or high capacity) and good rate-capability. Various efforts have been made to ameliorate this ...
Maki Toshio - - 2012
The template effect of 14-3-3 protein on the chemical ligation of fusicoccin derivatives containing an epoxide group and the pentapeptide QSYDC was investigated. HPLC analysis of the epoxide-opening reaction demonstrated that 14-3-3ζ protein improves the yield of the conjugate product compared to the protein-free control.
Campo Elias - - 2012
Two studies in this issue identify the landscape of somatic mutations in Burkitt lymphoma and highlight the pathogenic and clinical relevance of inactivating mutations of ID3, an inhibitor of the TCF3 transcription factor.
Guichoux E - - 2012
Loci considered to be under selection are generally avoided in attempts to infer past demographic processes as they do not fit neutral model assumptions. However, opportunities to better reconstruct some aspects of past demography might thus be missed. Here we examined genetic differentiation between two sympatric European oak species with ...
< 10 11 12 13 14 15 16 17 18 19 20 >