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Dong Chen - - 2012
Pro-inflammatory cytokines play a critical role in the development of autoimmune and inflammatory diseases. Targeting the cytokine environment has proven efficient for averting inflammation. In this study, we reported that 6-(4-(aminomethyl)-2-chlorophenoxyl)benzo[c][1,2]oxaborol-1(3H)-ol (AN3485), a benzoxaborole analog, inhibited TLR2-, TLR3-, TLR4- and TLR5-mediated TNF-α, IL-1β and IL-6 release from human PBMCs and ...
Subbarao Krishna V - - 2012
Verticillium wilt on spinach (Spinacia oleracea L.) is caused by the soilborne fungus, Verticillium dahliae. The pathogen is seedborne and transmission through seed is a major concern because of the dispersal of the pathogen to areas where fresh and processing spinach crops are grown in rotation with susceptible crops. Reduction ...
Zeilhofer Ulrike - - 2012
We report two children who developed severe, fatal pulmonary hypertension (PHT) after mismatched unrelated donor cord blood transplantation using reduced intensity conditioning for HLH. PHT was diagnosed on post mortem lung biopsies with no evidence of HLH, pulmonary veno-occlusive disease, infection or of idiopathic pulmonary hypertension. PHT may be an ...
Madathil Manikandadas M - - 2012
The synthesis of benzoquinone natural product 2 and three analogues is described. The synthesized compounds were tested for their ability to protect Friedreich's ataxia (FRDA) lymphocytes from induced oxidative stress. One of the analogues (3) conferred cytoprotection in a dose-dependent manner in FRDA lymphocytes at micromolar concentrations. The biological assays ...
Poussard Sylvie - - 2012
The gradual loss of muscle mass affecting all the elderly (sarcopenia) is most likely due to a decreased number and/or function of satellite cells. Accumulation of reactive oxygen species (ROS) has been clearly correlated to sarcopenia and could contribute to the impairment of satellite cell function. In this study, we ...
Lin Meng-Liang - - 2012
Stromal cell-derived factor-1α (SDF-1α) is a ligand for C-X-C chemokine receptor type 4 (CXCR4), which contributes to the metastasis of cancer cells by promoting cell migration. Here, we show that the SDF-1α/CXCR4 axis can significantly increase invasion of esophageal carcinoma (EC) cells. We accomplished this by examining the effects of ...
Myers Laura C - - 2012
Chemotherapy dosing in hematopoietic cell therapy (HCT) conditioning regimens is based on patient weight. We hypothesized that potential underdosing or overdosing of patients with significant deviation of weight from normal might alter HCT outcomes, such as early mortality, overall or organ-specific toxicity, and/or relapse. We therefore conducted a retrospective analysis ...
Burger Patrick - - 2012
During storage, erythrocytes undergo changes that alter their clearance and function after transfusion and there is increasing evidence that these changes contribute to the complications observed in transfused patients. Stored erythrocytes were incubated overnight at 37°C to mimic the temperature after transfusion. After incubation, several markers for erythrocyte damage were ...
Lin Yu-Chen - - 2012
A new metal-ion-responsive and fluorescent foldamer, OPLM(8) , composed of eight lysine-coumarin-azacrown units, has been designed and synthesized. The flexible OPLM(8) can be forced into a well-defined helix structure only upon the addition of alkaline earth metal ions. The structural change is based on the crown ether moieties being positioned ...
Burdzinski Gotard - - 2012
The photochemistry of diazocyclohexadienone, o-phenylene thioxocarbonate and 2-chlorophenol in solution was studied using time-resolved UV-vis and IR transient absorption spectroscopies. In these three cases, the same product cyclopentadienyl ketene is formed, and two different mechanistic pathways leading to this product are discussed: (a) rearrangement in the excited state (RIES), and ...
Fittschen Ursula Elisabeth Adriane - - 2012
Indoor aerosol exposure has become of major interest since health hazards arising from fine and ultra fine dust particles have become more evident. The study presented here is dedicated to fine and ultra fine dust characterisation and determination in more than 150 private residences with special respect to a phenomenon ...
Berstad Paula - - 2012
BACKGROUND: Both malnutrition and obesity are related to worsened post-operative outcomes after colorectal surgery. Obese cancer patients may be malnourished as a result of short-term weight loss. The present study aimed to evaluate preoperative nutritional status, body composition and dietary intake related to post-operative complications (POC) and post-operative hospital days ...
Edouard P - - 2012
This study aimed to record and analyse incidence and characteristics of injuries and illnesses incurred during the Indoor Athletics Championships. During the 2011 European Indoor Athletics Championships in Paris, incidence and characteristics of new injuries and illnesses were recorded prospectively by physicians and physiotherapists from national teams and local organizing ...
Dror Sayar - - 2012
Hemoglobin O-Arab [Beta 121 Glu → Lys] (Hb O-Arab) is a rare abnormal hemoglobin (Hb) whose clinical and hematological features have been described in adults but not in children. We report three children, 9, 12, and 36 months of age, with homozygous Hb O-Arab and assess the value of supplementary folic acid ...
Shacham Ranit - - 2012
Real-time monitoring of the thermal penetration depth (TPD) is essential in various clinical procedures, such as Laser Interstitial Thermal Therapy (LITT). MRI is commonly used to this end, though bulky and expensive. In this paper, we present an alternative novel method for an optical feedback system based on changes in ...
Gomes Neto Nelson Justino - - 2012
Abstract In this study, the inhibitory efficacy of Rosmarinus officinalis essential L. (ROEO) and 1,8-cineole (CIN) in inhibiting the growth and survival of Staphylococcus aureus ATCC 6538 and the induction of direct and bacterial cross protection (lactic acid pH 5.2; NaCl 100 g/L; high temperature 45°C) were evaluated following exposure to ...
Naeem Raeece - - 2012
SUMMARY: READSCAN is a highly scalable, parallel program to identify non-host sequences (of potential pathogen origin) and estimate their genome relative abundance in high throughput sequence datasets.READSCAN accurately classified human and viral sequences on a 20.1 million reads simulated dataset in less than 27 minutes using a small Beowulf compute ...
Gomes F S - - 2012
AIMS: Schinus terebinthifolius leaves are used for treating human diseases caused by microorganisms. This work reports the isolation, characterisation, and antimicrobial activity of S. terebinthifolius leaf lectin (SteLL). METHODS AND RESULTS: The isolation procedure involved protein extraction in 0.15 M NaCl, filtration through activated charcoal and chromatography of the filtrate ...
Scholz S - - 2012
Endocrine disruption is considered a highly relevant hazard for environmental risk assessment of chemicals, plant protection products, biocides and pharmaceuticals. Therefore, screening tests with a focus on interference with estrogen, androgen, and thyroid hormone pathways in fish and amphibians have been developed. However, they use a large number of animals ...
Kozicky S K - - 2012
BACKGROUND: Inuvialuit of Arctic Canada are at high risk for inadequate vitamin D status as a result of rapid dietary transitions and a lack of solar ultraviolet B exposure. This may have implications for the development of adverse skeletal diseases, cardiovascular diseases and cancers. Data are limited regarding supplement use ...
Umeki Saori - - 2012
P-selectin glycoprotein ligand-1 (PSGL-1) is an adhesive molecule that is known to be a ligand for P-selectin. An anti-adhesive property of PSGL-1 has not been previously reported. In this study, we show that PSGL-1 expression is anti-adhesive for adherent cells and we have elucidated the underlying mechanism. Overexpression of PSGL-1 ...
Heljo Ville P - - 2012
The objective of the study was to compare the effectiveness of trehalose with that of melibiose in protecting a monoclonal antibody (rituximab) from aggregation, fragmentation, and secondary structure alterations during processing and subsequent storage. Because reducing disaccharides such as melibiose participate in Maillard reaction with proteins, especially in the presence ...
Zeng Qi Long - - 2012
Aluminum (Al) accumulation and long-distance transport in oil tea (Camellia oleifera Abel.), known to be an Al accumulator, was investigated. The average Al concentration in the embryo of oil tea seeds was 389 mg Al kg(-1) dry weight, which was higher than seeds of other Al accumulators. By partially suppressing ...
Rossi Esther Diana - - 2012
BACKGROUND: Activating mutations in the valine-to-glutamic acid substitution at position 600 of the v-raf murine sarcoma viral oncogene homolog B1 (BRAF-1) gene are detected frequently in patients with papillary thyroid carcinoma (PTC). These mutations have been identified in approximately 29% to 69% of PTCs and in >80% of PTCs of ...
Carter Bernie - - 2012
A central concern when conducting qualitative health research with children is eliciting data that genuinely reflect their perspectives. Invariably, this involves being child-centered and participatory. Drawing and photography increasingly accompany dialogic methods to facilitate children's communication through arts-based and verbal modes of expression. However, little literature is available on how ...
Morgan Laura - - 2012
ABSTRACT An increase in the prescribing of opioids in an effort to improve management of chronic pain has led to enhanced availability of controlled substances for diversion and abuse. Evidence suggests that the use of prescription monitoring programs (PMPs) may help curtail this growing public health issue. The current use ...
Miljkovic Nenad - - 2012
When droplets coalesce on a superhydrophobic nanostructured surface, the resulting droplet can jump from the surface due to the release of excess surface energy. If designed properly, these superhydrophobic nanostructured surfaces can not only allow for easy droplet removal at micrometric length scales during condensation but promise to enhance heat ...
Kikukawa Yuji - - 2012
By the reaction of TBA(4)H(4)[γ-SiW(10)O(36)] (TBA = tetra-n-butylammonium) with AgOAc (OAc = acetate) using dimethylphenylsilane as a reductant in acetone, a unique polyoxometalate containing a discrete octahedrally shaped [Ag(6)](4+) cluster, TBA(8)[Ag(6)(γ-H(2)SiW(10)O(36))(2)]·5H(2)O, could be synthesized, and the molecular structure was determined.
Jiang Xuecheng - - 2012
The development of an indirect competitive immunomagnetic-proximity ligation assay (ICIPLA), which is a novel method for detecting small molecules, is described in this report. Free small molecules in samples can be detected using a proximity ligation assay (PLA); the detection is based on the proximity effect caused by a high ...
Omana-Zapata I - - 2012
INTRODUCTION: Hematopoietic stem cell transplantation, which requires accurate enumeration of stem cells, is routinely used in clinical settings. Flow cytometry provides a qualitative and quantitative assessment of CD34(+) cells. Precision, linearity, and stability of the novel BD™ Stem Cell Enumeration (SCE) Kit were evaluated on two flow cytometry platforms using ...
Smetana Volodymyr - - 2012
Golden opportunity: Na(13) Au(12) Ga(15) is the first Na-containing, thermodynamically stable quasicrystal and was discovered during systematic exploration of the polar intermetallic Na-Au-Ga system. Its electron-to-atom ratio, 1.75, is extremely low for Bergman-type icosahedral phases, but it is the substantial Au content that allows Hume-Rothery stabilization and promotes novel Na-Au ...
Lau Ching-Ching - - 2012
Mushrooms are high in protein content, which makes them potentially a good source of antihypertensive peptides. Among the mushrooms tested, protein extracts from Pleurotus cystidiosus (E1Pc and E5Pc) and Agaricus bisporus (E1Ab and E3Ab) had high levels of antihypertensive activity. The protein extracts were fractionated by reverse-phase high performance liquid ...
Wong Ying-Chieh - - 2012
The radical cascade protocol of the α-cyano α-TMS/aryl-capped alkynyl aryl ketones promoted by tert-butyl hydroperoxide under catalysis with tetrabutylammonium iodide in refluxing benzene has been developed, leading to the construction of a variety of highly functionalized [6,6,5] tricyclic frameworks in an efficient manner.
Serrano-Pérez Juan J - - 2012
The photocycloaddition reaction of benzene with ethylene has been studied at the CASSCF level, including the characterization of an extended conical intersection seam. We show that the chemical selectivity is, in part, controlled by this extended conical intersection seam and that the shape of the conical intersection seam can be ...
Zins Emilie-Laure - - 2012
Reactions between dilute methane and non-energetic hydroxyl radicals were carried out at 3.5 K. The temperature was kept low in order to characterize the step-wise reaction and prevent parasitic side reactions. The hydroxyl radicals originate from discharged H2O/He mixtures. The reactions were monitored in-situ using a Fourier transform infrared spectrometer. ...
Strong Vivian E - - 2012
BACKGROUND AND OBJECTIVES: Disease-specific survival (DSS) for GC patients differs in Eastern and Western countries. The aim is to compare outcomes of US and Korean patients following resection of early-stage, node-negative gastric carcinoma (GC). METHODS: All patients (1995-2005) with T1N0 gastric carcinoma, excluding gastroesophageal tumors, were evaluated. DSS was compared ...
Kale Akshay - - 2012
Insulator-based dielectrophoresis (iDEP) has been established as a powerful tool for manipulating particles in microfluidic devices. However, Joule heating may become an issue in iDEPmicrodevices due to the local amplification of electric field around the insulators.This results in an electrothermal force that can manifest itself in the flow field in ...
Pinaka Afroditi - - 2012
The ability of chiral β-amino alcohols to catalyze the direct asymmetric aldol reaction was evaluated for the first time in aqueous micellar media. A family of cheap and easily accessible β-amino alcohols, obtained in one step from naturally occurring amino acids, was shown to successfully catalyze the asymmetric aldol reaction ...
Meyer Haakon E - - 2012
BACKGROUND: It is biologically plausible that vitamin D might prevent prostate cancer. However, recent meta-analyses concluded that there is no consistent relation between circulating 25-hydroxyvitamin D [25(OH)D] concentrations and prostate cancer, and several large studies have actually reported increased risk of prostate cancer associated with high 25(OH)D. OBJECTIVE: We aimed ...
Amenta Valeria - - 2012
The association constants for formation of 1:1 complexes between a H-bond acceptor, tri-n-butylphosphine oxide, and a H-bond donor, 4-phenylazophenol, have been measured in a range of different solvent mixtures. Binary mixtures of n-octane and a more polar solvent (ether, ester, ketone, nitrile, sulfoxide, tertiary amide, and halogenated and aromatic solvents) ...
Newman Erik N - - 2012
BACKGROUND: Staging investigations following the diagnosis of Ewing sarcoma may include chest computerized tomography (CT), technetium bone scintigraphy (bone scan), [F-18]-fluorodeoxy-D-glucose positron emission tomography (FDG-PET) scan, and bone marrow biopsy and aspiration (BMA/Bx). Each of these staging investigations provides complementary prognostic information, however the optimal combination of staging investigations is ...
Listing Joachim - - 2012
RA is known to be associated with an increased risk of serious infection. Even more than 50 years ago, observational studies showed a greater than 2-fold increased risk of serious infection in RA. This was reinforced by various subsequent cohort studies. The elevated susceptibility of patients with RA can be ...
Müllerová Ludmila - - 2012
A neutral marker of the electroosmotic flow (EOF) can gain a nonzero effective mobility because of its possible interaction with a charged complexing agent, such as a chiral selector in capillary electrophoresis. We determined effective mobilities of four compounds often used as EOF markers (dimethyl sulfoxide, mesityl oxide, nitromethane and ...
Sansuk Siriwat - - 2012
The electrochemical measurement of dopamine (DA), in phosphate buffer solution (pH 7.4), with a limit of detection (LOD) of ~ 5 pM in 50 μL (~ 250 attomole) is achieved using a band electrode comprising a sparse network of pristine single walled carbon nanotubes (SWNTs), which covers less than one ...
Blagosklonny Mikhail V - - 2012
Although hypoxia can cause cell cycle arrest, it may simultaneously suppress a conversion from this arrest to senescence. Furthermore, hypoxia can suppress senescence caused by diverse stimuli, maintaining reversible quiescence instead. Hypoxia activates autophagy and inhibits MTOR, thus also activating autophagy. What is the relationship between autophagy and cellular senescence? ...
Rial Ruben Victor - - 2012
Unilateral sleep in marine mammals has been considered as a defence against airway obstruction, as a sentinel for pod maintenance, and as a thermoregulatory mechanism. Birds also show asymmetric sleep, probably to avoid predation. The variable function of asymmetric sleep suggests a general capability for independence between brain hemispheres. Patients ...
Westlake Brittany Cole - - 2012
Excited state proton transfer dynamics between 7-hydroxy-4-(trifluoromethyl)-coumarin and 1-methylimidazole base in toluene were studied using ultrafast pump-probe and time-resolved emission methods. Charge transfer excitation of the hydroxycoumarin shifts electron density from the hydroxyl group to the carbonyl, resulting in an excited state where proton transfer to base is highly favored. ...
Ottakam Thotiyl Muhammed Musthafa - - 2012
Carbon has been used widely as the basis of porous cathodes for non-aqueous Li-O2 cells. However, the stability of carbon and the effect of carbon on electrolyte decomposition in such cells are complex and depend on the hydrophobicity/hydrophilicity of the carbon surface. Analyzing carbon cathodes, cycled in Li-O2 cells between ...
Yamamoto Junya - - 2012
It is suggested that pro-inflammatory cytokines, which are produced by interaction of the intervertebral nucleus pulposus cells and macrophages, may be linked to the cause of pain of the intervertebral disc herniation. This study carries out the in vitro experiments to examine the mechanism, with the use of the co-culture ...
Ysasi Gonzalo Gurrea - - 2012
Differences between global radiation UVER (erythemal ultraviolet solar radiation) received under full sun and diffuse radiation received under the shadow of two types of tree are analyzed in order to check the importance of these components on human exposure to UV radiation. Blue Line spores dosimeters of VioSpor were used ...
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