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Results 601 - 650 of 2474
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Carter Dan - - 2013
The prevalence of gastrointestinal lesions in young men with iron deficiency anemia (IDA) is unknown, and there are no evidence-based recommendations for the evaluation of the gastrointestinal tract in this population. The purpose of this study was to assess the prevalence of significant GI lesions among young males with IDA, ...
He Xiao-Jin - - 2013
PRDM9 is essential for the progression through early meiotic prophase, including double strand break repair, homologous chromosome pairing, and sex body formation during spermatogenesis. In order to evaluate the association of the PRDM9 gene variants with defective spermatogenesis in the Chinese Han population, we assessed two single nucleotide polymorphisms (SNPs) ...
García-Blázquez V - - 2013
To assess the diagnostic accuracy of computed tomography (CT) angiography in the evaluation of patients with an episode of acute gastrointestinal haemorrhage. Systematic review and meta-analysis to estimate pooled accuracy indices. A bivariate random effects model was adjusted to obtain a summary receiver-operating characteristic (sROC) curve and the corresponding area ...
Del Giudice Giuseppe - - 2013
Aflunov is an egg-derived, subunit vaccine from Novartis Vaccines and Diagnostics containing 7.5 μg of hemagglutinin (HA) from the avian A/H5N1 virus and the oil-in-water adjuvant MF59. Aflunov behaves as a pre-pandemic vaccine. It has a good safety profile at all ages. At all ages, it induces high and persisting ...
Friedman Adam J - - 2013
Advances in nanotechnology have demonstrated potential application of nanoparticles (NPs) for effective and targeted drug delivery. Here we investigated the antimicrobial and immunological properties and the feasibility of using NPs to deliver antimicrobial agents to treat a cutaneous pathogen. NPs synthesized with chitosan and alginate demonstrated a direct antimicrobial activity ...
Boyd Suzanah C - - 2013
Approximately 50% of melanomas require oncogenic B-RAF(V600E) signaling for proliferation, survival, and metastasis, and the use of highly selective B-RAF inhibitors has yielded remarkable, although short-term, clinical responses. Reactivation of signaling downstream of B-RAF is frequently associated with acquired resistance to B-RAF inhibitors, and the identification of B-RAF targets may ...
Ricci Zaccaria - - 2012
ABSTRACT: Diagnosis and classification of acute kidney injury was addressed systematically only 8 years ago when the classification called RIFLE (acronym of Risk, Injury, Failure, Loss of function and End stage Kidney disease describing progressive severity of renal damage) was created. Since then, several studies have tried to apply, validate, ...
Marques Tiago A TA Centre for Research into Ecological and Environmental Modelling, University of St Andrews, The Observatory, Buchanan Gardens, Fife, KY16 9LZ, UK. - - 2013
Reliable estimation of the size or density of wild animal populations is very important for effective wildlife management, conservation and ecology. Currently, the most widely used methods for obtaining such estimates involve either sighting animals from transect lines or some form of capture-recapture on marked or uniquely identifiable individuals. However, ...
Veugen Lidwien C LC Department of Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The - - 2013
Writer's cramp is a task-specific form of focal dystonia, characterized by abnormal movements and postures of the hand and arm during writing. Two consistent abnormalities in its pathophysiology are a loss of surround inhibition and overactivity of the dorsal premotor cortex (PMd). This study aimed to assess a possible link ...
Wiggett Alison J AJ School of Psychology, Adeilad Brigantia, Bangor University, Bangor, LL57 2AS, Wales, UK. - - 2013
The observation of someone else's action facilitates similar actions in the observer. Such priming effects can be driven by alignment between the observer and the observed in body-centred or spatial coordinates (or both). The separate and joint contributions of these sources of priming remain to be fully characterised. Here, we ...
Hazra S S Pharmacology & Therapeutics, University of Florida, 1600 SW Archer Road, Academic Research Building, PO 100267, Gainesville, FL 32610-0267, - - 2013
We sought to determine the impact of long-standing type 1 diabetes on haematopoietic stem/progenitor cell (HSC) number and function and to examine the impact of modulating glycoprotein (GP)130 receptor in these cells. Wild-type, gp130(-/-) and GFP chimeric mice were treated with streptozotocin to induce type 1 diabetes. Bone marrow (BM)-derived ...
Kotdawala Aditi P AP Clinical Embryology, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal, 576 104, - - 2012
To study the effect of addition of zinc to human semen sample prior to cryopreservation on post-thaw sperm quality and function. Semen samples were collected from men attending university infertility clinic for semen analysis (n=109). Liquefied semen samples were cryopreserved in glycerol-egg yolk- citrate medium with or without the prior ...
Holdsworth C H CH Department of Radiation Oncology, University of Washington Medical Center, 1959 N E Pacific Street, Seattle, WA 98195, USA. - - 2012
We demonstrate a patient-specific method of adaptive IMRT treatment for glioblastoma using a multiobjective evolutionary algorithm (MOEA). The MOEA generates spatially optimized dose distributions using an iterative dialogue between the MOEA and a mathematical model of tumor cell proliferation, diffusion and response. Dose distributions optimized on a weekly basis using ...
Ye Hui H School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705-2222, - - 2013
Considerable effort has been devoted to characterizing the crustacean stomatogastric nervous system (STNS) with great emphasis on comprehensive analysis and mapping distribution of its diverse neuropeptide complement. Previously, immunohistochemistry (IHC) has been applied to this endeavor, yet with identification accuracy and throughput compromised. Therefore, molecular imaging methods are pursued to ...
Young Michael D MD Colorado School of Mines, Department of Physics, Golden, Colorado, USA. - - 2013
A direct-diode pumped Ti:sapphire femtosecond oscillator is used to perform multiphoton imaging for the first time.
Danaher Robert J RJ Department of Oral Health Practice, Division of Oral Medicine, Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY 40536-0297, - - 2013
The HSV-1 tegument protein VP16 contains a trans-activation domain (TAD) that is required for induction of immediate early (IE) genes during lytic infection and induced reactivation from latency. Here we report the differential contributions of the two sub-regions of the TAD in neuronal and non-neuronal cells during activation of IE ...
Kraja Aldi T AT Division of Statistical Genomics, Washington University School of Medicine, 4444 Forest Park Ave, Campus Box 8506, St. Louis, MO 63108, USA. - - 2013
Sixteen nuclear magnetic resonance (NMR) spectroscopy lipoprotein measurements of more than 1,000 subjects of GOLDN study, at fasting and at 3.5 and 6 h after a postprandial fat (PPL) challenge at visits 2 and 4, before and after a 3 weeks Fenofibrate (FF) treatment, were included in 6 time-independent multivariate ...
Stratford Thomas R TR Laboratory of Integrative Neuroscience, Department of Psychology (m/c 285), University of Illinois at Chicago, Chicago, IL, USA. - - 2013
Intense feeding can be elicited by injections of the GABA(A) receptor antagonist bicuculline into the medial ventral pallidum (VPm), a basal forebrain structure anatomically interposed between two other feeding-related brain regions, the nucleus accumbens shell and the lateral hypothalamus (LH). To determine whether the VPm effects changes in feeding behavior ...
Baliban Richard C RC Department of Chemical and Biological Engineering, Princeton University, Princeton, - - 2013
To identify optimal combination(s) of proteomic based biomarkers in gingival crevicular fluid (GCF) samples from chronic periodontitis (CP) and periodontally healthy individuals and validate the predictions through known and blind test sets. GCF samples were collected from 96 CP and periodontally healthy subjects and analysed using high-performance liquid chromatography, tandem ...
Mustjoki S S Hematology Research Unit Helsinki, Department of Medicine, Division of Hematology, University of Helsinki and Helsinki University Central Hospital (HUCH), Helsinki, - - 2013
Tyrosine kinase inhibitors (TKIs) have potent effects on malignant cells, and they also target kinases in normal cells, which may have therapeutic implications. Using a collection of 55 leukemia patients treated with TKI therapy (chronic myeloid leukemia, n=47; acute lymphoblastic leukemia, n=8), we found that dasatinib, a second-generation broad-spectrum TKI, ...
Chahal N S NS Department of Cardiovascular Medicine, Northwick Park Hospital, Royal Brompton Hospital, Harrow, London, - - 2013
Individuals of Indian Asian ethnicity living in the U.K. have at least a 50% excess of cardiovascular disease (CVD) mortality compared with European whites, yet there are no validated tools capable of identifying this excess risk. Left ventricular hypertrophy (LVH) is a powerful prognosticator for future CVD events but its ...
Bugaut Anthony A Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. - - 2012
RNA molecules can fold into noncanonical structures such as the four-stranded structures known as G-quadruplexes. G-quadruplexes in the transcriptome have recently emerged as relevant regulatory elements of gene expression. Conformational transitions in RNA molecules offer an important way to regulate their biological functions. Here we report on the competition between ...
Hochgräfe Katja K DZNE (German Center for Neurodegenerative Diseases), Ludwig-Erhard-Allee 2, 53175 Bonn, - - 2013
Bioluminescence imaging (BLI) takes advantage of the light-emitting properties of luciferase enzymes, which produce light upon oxidizing a substrate (i.e., D-luciferin) in the presence of molecular oxygen and energy. Photons emitted from living tissues can be detected and quantified by a highly sensitive charge-coupled device camera, enabling the investigator to ...
Green Robert T RT School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, - - 2013
We showed that two very different manganese transporters occur in various important genera of marine bacteria. The ABC transporter encoded by sitABCD of the model Roseobacter-clade bacterium Ruegeria pomeroyi DSS-3 is required for Mn(2+) import and was repressed by the Mur (Manganese uptake regulator) transcriptional regulator in Mn-replete media. Most ...
Passiment Elissa E American Society for Clinical Laboratory Science, Tysons Corner, VA, USA. - - 2013
Clinical laboratory tests have no value if clinicians cannot quickly order and obtain the results they need. We found that efforts to obtain even the most commonly ordered tests are often derailed by excessively complex nomenclature. Ordering the right laboratory tests is critical to diagnosis and treatment, but existing mechanisms ...
Nagy Gergő A GA Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1450 Budapest, - - 2013
Members of the transient receptor potential (TRP) cation channel family play important roles in several neuronal functions. To understand the precise role of these channels in information processing, their presence on neuronal elements must be revealed. In this study, we investigated the localization of TRPC6 channels in the adult hippocampal ...
Miyake Takahito M TM Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, 1155 Herman Pressler, Unit 1362, Houston, TX 77030, - - 2013
Ovarian cancer remains the most lethal gynecologic malignancy. Although standard platinum-based chemotherapy results in high response rates, more than 70% of patients with advanced disease will experience recurrence within 5 years. Therefore, novel treatment strategies to increase primary efficacy, decrease recurrence after primary treatment and improve the response rate for ...
Jiang J J Department of Psychology and the California National Primate Research Center, University of California, Davis, CA 95616, USA. - - 2013
The use of Chinese-origin macaques in biomedical research is problematic for some scientists because of the reported behavioral and physiological differences from those of Indian origin. However, few studies have examined the effects of varying degrees of Chinese ancestry (DCA) on behavior, and they were typically based on small sample ...
Scardochio Tina T Department of Pharmacology and Therapeutics, McGill University, McIntyre Medical Building Rm. 1320, 3655 Promenade Sir William Osler, Montreal, QC, H3G 1Y6, - - 2013
Adult rats emit ultrasonic calls at around 22 and 50 kHz, which are often elicited by aversive and rewarding stimuli, respectively. Dopamine (DA) plays a role in aspects of both reward and aversion. The purpose of this study is to investigate the effects of DA receptor subtype-selective agonists on 22- ...
Hamdan Leila J LJ Marine Biogeochemistry Section, Code 6114, US Naval Research Laboratory, Washington DC 20375, USA. - - 2013
Prokaryote communities were investigated on the seasonally stratified Alaska Beaufort Shelf (ABS). Water and sediment directly underlying water with origin in the Arctic, Pacific or Atlantic oceans were analyzed by pyrosequencing and length heterogeneity-PCR in conjunction with physicochemical and geographic distance data to determine what features structure ABS microbiomes. Distinct ...
Tims Sebastian S Laboratory of Microbiology, Wageningen University and TI Food and Nutrition, Wageningen, The - - 2013
The human gastrointestinal (GI) tract microbiota acts like a virtual organ and is suggested to be of great importance in human energy balance and weight control. This study included 40 monozygotic (MZ) twin pairs to investigate the influence of the human genotype on GI microbiota structure as well as microbial ...
Handley Kim M KM Department of Earth and Planetary Science, University of California, Berkeley, CA 94720-4767, - - 2013
Stimulation of subsurface microorganisms to induce reductive immobilization of metals is a promising approach for bioremediation, yet the overall microbial community response is typically poorly understood. Here we used proteogenomics to test the hypothesis that excess input of acetate activates complex community functioning and syntrophic interactions among autotrophs and heterotrophs. ...
Burow Luke C LC Departments of Chemical Engineering and Civil and Environmental Engineering, Stanford University, Stanford, CA, - - 2013
Photosynthetic microbial mats possess extraordinary phylogenetic and functional diversity that makes linking specific pathways with individual microbial populations a daunting task. Close metabolic and spatial relationships between Cyanobacteria and Chloroflexi have previously been observed in diverse microbial mats. Here, we report that an expressed metabolic pathway for the anoxic catabolism ...
Pasternak Zohar Z Department of Plant Pathology and Microbiology, The Hebrew University of Jerusalem, Rehovot, Israel. - - 2013
Predatory bacteria are taxonomically disparate, exhibit diverse predatory strategies and are widely distributed in varied environments. To date, their predatory phenotypes cannot be discerned in genome sequence data thereby limiting our understanding of bacterial predation, and of its impact in nature. Here, we define the 'predatome,' that is, sets of ...
True Gala G Center for Evaluation of Patient Aligned Care Teams (CEPACT), Philadelphia Veterans Affairs Medical Center, Building 4100, University and Woodland Aves, Philadelphia, PA 19104, USA. - - 2013
The Veterans Health Administration (VHA) has undertaken a 5-year initiative to transform to a patient-centered medical home model. An early focus of implementation was on creating open access, defined as continuity and capacity in primary care. We describe the impact of readiness for implementation on efforts of pilot teams to ...
Rogers Geraint B GB Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Science, King's College London, London, - - 2013
High-throughput pyrosequencing and quantitative PCR (Q-PCR) analysis offer greatly improved accuracy and depth of characterisation of lower respiratory infections. However, such approaches suffer from an inability to distinguish between DNA derived from viable and non-viable bacteria. This discrimination represents an important step in characterising microbial communities, particularly in contexts with ...
Lutgen Victoria V Department of Biomedical Sciences, Marquette University, Suite 446, 561 N. 15th St, Milwaukee, WI 53233, - - 2013
Aspects of schizophrenia, including deficits in sensorimotor gating, have been linked to glutamate dysfunction and/or oxidative stress in the prefrontal cortex. System xc(-), a cystine-glutamate antiporter, is a poorly understood mechanism that contributes to both cellular antioxidant capacity and glutamate homeostasis. Our goal was to determine whether increased system xc(-) ...
Wozniak Jeffrey R JR Department of Psychiatry, University of Minnesota, Twin Cities, F256/2B West, 2450 Riverside Ave., Minneapolis, MN 55454, USA. - - 2013
Diffusion tensor imaging was used to evaluate cerebral white matter in 16 patients (ages 9-18) with myotonic dystrophy type 1 compared to 15 matched controls. Patients with myotonic dystrophy showed abnormalities in mean diffusivity compared to controls in frontal, temporal, parietal, and occipital white matter and in all individual tracts ...
Conceição Eva E CIPsi - Center for Research in Psychology, University of Minho, School of Psychology, Braga, Portugal. - - 2013
A significant number of post-bariatric surgery (BS) patients present with eating disorders (EDs) symptoms that require specialized treatment. These cases are thought to be underreported due to their frequent sub-syndromal presentation. This article describes ED syndromes that develop subsequent to BS. The clinical charts of 12 individuals who were hospitalized ...
Woon Jason T K JT Department of Anatomy, Otago School of Medical Sciences, University of Otago, PO Box 913, Dunedin, New - - 2013
Lack of data on the in vivo morphology and morphometry of the normal adult coccyx hampers understanding of radiological abnormalities in idiopathic coccydynia. The aim of this study was to investigate normal adult sacrococcygeal morphometry. Retrospective analysis of 112 adult CT scans (mean age 63 ± 14.6 years, 50 males) ...
Reuland Steven N SN Department of Dermatology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, - - 2013
Melanoma is an aggressive cancer that metastasizes rapidly and is refractory to conventional chemotherapies. Identifying microRNAs (miRNAs) that are responsible for this pathogenesis is therefore a promising means of developing new therapies. We identified miR-26a through microarray and quantitative reverse-transcription-PCR (qRT-PCR) experiments as an miRNA that is strongly downregulated in ...
Chren Mary-Margaret MM Department of Dermatology, University of California at San Francisco, San Francisco, California 94143-0808, USA. - - 2013
For most cutaneous basal cell and squamous cell carcinomas (nonmelanoma skin cancers (NMSCs)), data are insufficient to permit evidence-based choices among treatments. To compare tumor recurrence after treatments, we conducted a prospective cohort study of consecutive patients with primary NMSCs treated with the most common treatments, in two practices in ...
Victoroff Michael S MS Department of Family Medicine, University of Colorado School of Medicine, 5195 E. Weaver Dr., Centennial, CO 80121-3500, USA. - - 2013
Electronic health records (EHRs) might reduce medical liability claims and potentially justify premium credits from liability insurers, but the evidence is limited. To evaluate the association between EHR use and medical liability claims in a population of office-based physicians, including claims that could potentially be directly prevented by features available ...
Paulson Kelly G KG Division of Dermatology, Department of Internal Medicine, University of Washington, Seattle, Washington 98109, - - 2013
Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy linked to a contributory virus (Merkel cell polyomavirus). Multiple epidemiologic studies have established an increased incidence of MCC among persons with systemic immune suppression. Several forms of immune suppression are associated with increased MCC incidence, including hematologic malignancies, HIV/AIDS, and immunosuppressive ...
Edwardson M A MA NINDS Stroke Branch, National Institutes of Health, 10 Center Dr., Room B1D-733, MSC 1063, Bethesda, MD 20892-1063, USA. - - 2013
Stroke is a leading cause of disability, and the number of stroke survivors continues to rise. Traditional neurorehabilitation strategies aimed at restoring function to weakened limbs provide only modest benefit. New brain stimulation techniques designed to augment traditional neurorehabilitation hold promise for reducing the burden of stroke-related disability. Investigators discovered ...
Yousef George M GM Joan C. Edwards School of Medicine, Marshall University, 1249 15th St, Huntington, WV 25701, - - 2013
A 64-year-old woman presented with a hemorrhagic perifollicular rash on her legs while taking warfarin. After biopsy, vitamin C deficiency was suggested as the diagnosis, which ascorbic acid assays later confirmed. Clinical resolution of the rash followed supplementation with vitamin C. Patients on a vitamin K limited diet may also ...
Wang Ying Y Department of Biology, McGill University, Montréal, Quebec, - - 2013
Ubiquinone (UQ), also known as coenzyme Q (CoQ), is a redox-active lipid present in all cellular membranes where it functions in a variety of cellular processes. The best known functions of UQ are to act as a mobile electron carrier in the mitochondrial respiratory chain and to serve as a ...
Han Hai-Chao HC Department of Mechanical Engineering, The University of Texas at San Antonio-UTSA, San Antonio, TX 78249, USA. - - 2013
Arteries are under significant mechanical loads from blood pressure, flow, tissue tethering, and body movement. It is critical that arteries remain patent and stable under these loads. This review summarizes the common forms of buckling that occur in blood vessels including cross-sectional collapse, longitudinal twist buckling, and bent buckling. The ...
Cortes Jorge E JE Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. - - 2012
Resistance to tyrosine kinase inhibitors in patients with chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL) is frequently caused by mutations in the BCR-ABL kinase domain. Ponatinib (AP24534) is a potent oral tyrosine kinase inhibitor that blocks native and mutated BCR-ABL, including the gatekeeper mutant T315I, ...
Ermakov Igor V IV Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112, - - 2013
We describe Resonance Raman based skin carotenoid measurements in newborns and infants. Skin- and serum carotenoid levels correlate with high statistical significance in healthy newborns and infants, and with reduced accuracy also in prematurely born infants, who in general feature very low carotenoid levels and thin transparent skin giving rise ...
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