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Results 501 - 550 of 2475
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Mustjoki S S Hematology Research Unit Helsinki, Department of Medicine, Division of Hematology, University of Helsinki and Helsinki University Central Hospital (HUCH), Helsinki, - - 2013
Tyrosine kinase inhibitors (TKIs) have potent effects on malignant cells, and they also target kinases in normal cells, which may have therapeutic implications. Using a collection of 55 leukemia patients treated with TKI therapy (chronic myeloid leukemia, n=47; acute lymphoblastic leukemia, n=8), we found that dasatinib, a second-generation broad-spectrum TKI, ...
Simons Leslie Gordon - - 2012
Corporal punishment is a controversial practice used by the majority of American parents and is especially prevalent among African Americans. Research regarding its consequences has produced mixed results although it is clear that there is a need for considering the context within which corporal punishment is administered. To assess the ...
Monterroso Joanne - - 2012
A 63-year-old man presented with a 6-month history of fatigue, weight loss, and gingival bleeding. Physical examination suggested the presence of a massively enlarged spleen, a finding confirmed on a reconstructed coronal CT image of the abdomen.
Carlsund Asa - - 2012
AIM: In Sweden, shared physical custody following a parental separation has emerged as means for children to keep close relationships with both parents. Previous studies show that children benefit from regular contact with both parents, who share responsibility for their social, emotional, and economic welfare. In this study we investigate ...
Yoshizumi Tomoharu - - 2012
AIM: Hepatocellular carcinoma (HCC) is primarily treated with hepatic resection and/or locoregional therapy. When HCC recurs and further treatment is no longer possible owing to poor liver function, liver transplantation (LT) or living-donor LT (LDLT) is considered. The aim of this study was to clarify risk factors for tumor recurrence ...
Burow Luke C LC Departments of Chemical Engineering and Civil and Environmental Engineering, Stanford University, Stanford, CA, - - 2013
Photosynthetic microbial mats possess extraordinary phylogenetic and functional diversity that makes linking specific pathways with individual microbial populations a daunting task. Close metabolic and spatial relationships between Cyanobacteria and Chloroflexi have previously been observed in diverse microbial mats. Here, we report that an expressed metabolic pathway for the anoxic catabolism ...
Nogarol Larissa Rosa - - 2012
This study presents the morphological description and histochemical characterization of gill filaments of the Brazilian endemic bivalve Diplodon expansus, aiming to broaden the morphological knowledge of this species and establish the structure of the gills that will serve as control in histopathological studies applied to biomonitoring. The gill filaments are ...
Pajski Megan L - - 2012
Adenosine plays an important role in neuromodulation and neuroprotection. Recent identification of transient changes in adenosine concentration suggests adenosine may have a rapid modulatory role; however, the extent of these changes throughout the brain is not well understood. In this report, transient changes in adenosine evoked by one second, 60 Hz ...
Loscha Karin V - - 2012
Stereospecific resonance assignments of the α-protons of glycine are often difficult to obtain by measurements of scalar coupling constants or nuclear Overhauser effects. Here we show that these stereospecific resonance assignments can readily be obtained by cell-free protein synthesis in D(2)O, as the serine hydroxymethyltransferase, that is naturally present in ...
Zhao Bo - - 2012
In this study, we investigated the effectiveness of a novel iterative reconstruction (IR) method coupled with dual-dictionary learning (DDL) for image reconstruction in a dedicated breast computed tomography (CT) system based on a cadmium-zinc-telluride (CZT) photon-counting detector and compared it to the filtered-back-projection (FBP) method with the ultimate goal of ...
Adams I P - - 2012
The complete genome sequences of RNA1 and RNA2 of the oca strain of the potato virus arracacha virus B were determined using next-generation sequencing. The RNA1 molecule is predicted to encode a 259-kDa polyprotein with homology to proteins of the cheraviruses apple latent spherical virus (ALSV) and cherry rasp leaf ...
Jiang J J Department of Psychology and the California National Primate Research Center, University of California, Davis, CA 95616, USA. - - 2013
The use of Chinese-origin macaques in biomedical research is problematic for some scientists because of the reported behavioral and physiological differences from those of Indian origin. However, few studies have examined the effects of varying degrees of Chinese ancestry (DCA) on behavior, and they were typically based on small sample ...
Parkinson Bonny - - 2012
BACKGROUND: Lower back pain is a common and costly condition in Australia. This paper aims to conduct an economic evaluation of lumbar artificial intervertebral disc replacement (AIDR) compared with lumbar fusion for the treatment of patients suffering from significant axial back pain and/or radicular (nerve root) pain, secondary to disc ...
Satola Barbara - - 2012
This review outlines information about the Gram-negative, aerobic bacterium Variovorax paradoxus. The genomes of these species have G+C contents of 66.5-69.4 mol%, and the cells form yellow colonies. Some strains of V. paradoxus are facultative lithoautotrophic, others are chemoorganotrophic. Many of them are associated with important catabolic processes including the degradation ...
Welch K A - - 2012
BACKGROUND: Schizophrenia is associated with various brain structural abnormalities, including reduced volume of the hippocampi, prefrontal lobes and thalami. Cannabis use increases the risk of schizophrenia but reports of brain structural abnormalities in the cannabis-using population have not been consistent. We used automated image analysis to compare brain structural changes ...
Ermakov Igor V IV Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112, - - 2013
We describe Resonance Raman based skin carotenoid measurements in newborns and infants. Skin- and serum carotenoid levels correlate with high statistical significance in healthy newborns and infants, and with reduced accuracy also in prematurely born infants, who in general feature very low carotenoid levels and thin transparent skin giving rise ...
Yol Aleer M - - 2012
[M + Ag](+) ions from cyclic and linear polystyrenes and polybutadienes, formed by matrix-assisted laser desorption ionization (MALDI), give rise to significantly different fragmentation patterns in tandem mass spectrometry (MS(2)) experiments. In both cases, fragmentation starts with homolytic cleavage at the weakest bond, usually a C-C bond, to generate two ...
Mark Alicja Budek - - 2012
Agricultural methods may affect the nutritional composition of plants and cause complex changes in the food matrix. Whether this affects the dietary absorption of minerals that are important for maintaining health thorough life remains unclear. We compared the effects of organic and conventional diets on intake and absorption of zinc ...
Ambili T R - - 2012
Oxytetracycline (OTC), an antibacterial agent, is extensively used in aquaculture practices all over the world. Despite its use, the toxicity of OTC to freshwater fish has been scarcely investigated. In this study, Labeo rohita were exposed to different concentrations (20, 40, 60, 80, 100, and 120 mg L(-1)) of OTC. Based on ...
Kreutmayer Simone - - 2012
We identified increased expression and redistribution of the intracellular protein 60-kDa human heat shock protein (hHSP60) (HSPD1) to the cell surface in human endothelial cells subjected to classical atherosclerosis risk factors and subsequent immunologic cross-reactivity against this highly conserved molecule, as key events occurring early in the process of atherosclerosis. ...
- - 2012
To the Editor: Zhuang et al. (Sept. 6 issue)(1) report HIF2A somatic mutations in two patients with paraganglioma. In a recent transcriptome analysis of a large number of pheochromocytomas and paragangliomas, we identified 16 sporadic tumors with a transcription signature similar to that of VHL-mutated tumors.(2) There was somatic inactivation ...
Danaher Robert J RJ Department of Oral Health Practice, Division of Oral Medicine, Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY 40536-0297, - - 2013
The HSV-1 tegument protein VP16 contains a trans-activation domain (TAD) that is required for induction of immediate early (IE) genes during lytic infection and induced reactivation from latency. Here we report the differential contributions of the two sub-regions of the TAD in neuronal and non-neuronal cells during activation of IE ...
Nishimura Tomoki - - 2012
We have developed a simple and robust fluorescence based boronic-acid molecular sensor for determining the concentration of fluoride in water at environmentally significant levels. The simplicity of the method and the ability to measure fluoride in water between 0.1 and 1.5 ppm is particularly noteworthy given the WHO requirements for ...
Veugen Lidwien C LC Department of Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The - - 2013
Writer's cramp is a task-specific form of focal dystonia, characterized by abnormal movements and postures of the hand and arm during writing. Two consistent abnormalities in its pathophysiology are a loss of surround inhibition and overactivity of the dorsal premotor cortex (PMd). This study aimed to assess a possible link ...
Tang-Feldman Yajarayma J - - 2012
Multiple studies suggest an association between cytomegalovirus (CMV) infection and atherogenesis; however, the molecular mechanisms by which viral infection might exacerbate atherosclerosis are not well understood. Aortas of MCMV-infected and uninfected Apo E knockout (KO) mice were analyzed for atherosclerotic lesion development and differential gene expression. Lesions in the infected ...
de Wit Sanne - - 2012
Studies of incongruent discrimination learning, where the outcome event of one response acts as the discriminative stimulus for the opposite response, suggest that humans rely on habitual stimulus-response (S-R) associations when outcome-response (O-R) associations would cause response conflict. Here, two experiments were conducted to investigate the robustness of this habitual ...
Hamdan Leila J LJ Marine Biogeochemistry Section, Code 6114, US Naval Research Laboratory, Washington DC 20375, USA. - - 2013
Prokaryote communities were investigated on the seasonally stratified Alaska Beaufort Shelf (ABS). Water and sediment directly underlying water with origin in the Arctic, Pacific or Atlantic oceans were analyzed by pyrosequencing and length heterogeneity-PCR in conjunction with physicochemical and geographic distance data to determine what features structure ABS microbiomes. Distinct ...
Ruiz-Espinosa H - - 2012
Multiple-pass UHPH was used for reducing microbial population of both indigenous spoilage microflora in whole raw milk and a baroresistant pathogen (Staphylococcus aureus) inoculated in whole sterile milk to define pasteurization-like processing conditions. Response surface methodology was followed and multiple response optimization of UHPH operating pressure (OP) (100, 175, 250 ...
Andersson Roland E - - 2012
BACKGROUND: Avoiding mortality is the ultimate goal when managing patients with suspected appendicitis. Previous studies have shown high mortality after negative appendectomy. This national cohort study analyzes short- and long-term mortality after appendectomy in relation to appendectomy diagnosis, age, co-morbidity, surgical method, hospital volume, and time period. METHOD: A total ...
Young Michael D MD Colorado School of Mines, Department of Physics, Golden, Colorado, USA. - - 2013
A direct-diode pumped Ti:sapphire femtosecond oscillator is used to perform multiphoton imaging for the first time.
Loots C - - 2012
Background  Posture has been shown to influence the number of transient lower esophageal sphincter relaxation (TLESRs) and gastroesophageal reflux (GER), however, the physiology explaining the influence of right lateral position (RLP), and left lateral position (LLP) is not clear. The aim of this study was to determine the influence of ...
Schwarz Silke - - 2012
One key point in the development of new bioimplant matrices for the reconstruction and replacement of cartilage defects is to provide an adequate microenvironment to ensure chondrocyte migration and de novo synthesis of cartilage-specific extracellular matrix (ECM). A recently developed decellularization and sterilization process maintains the three-dimensional (3D) collagen structure ...
SokoĊ‚owska Barbara - - 2012
Delayed diagnosis in patients with Churg-Strauss syndrome (CSS) is largely attributed to the variable and nonspecific presentation of the disease's initial symptoms. The aim of the study was to evaluate the effect of delayed diagnosis on the course of CSS. We conducted a retrospective study of 30 CSS patients followed ...
Bastiaans Diane E T DE Máxima Medical Centre, Eindhoven/Veldhoven, The Netherlands, - - 2013
Patients who remain comatose after resuscitation are treated with moderate hypothermia. Little is known about the pharmacokinetics of drugs in patients who are treated with moderate hypothermia. We investigated the pharmacokinetics of midazolam in resuscitated patients treated with moderate hypothermia in comparison to normothermic and non-resuscitated patients. This study was ...
Chahal N S NS Department of Cardiovascular Medicine, Northwick Park Hospital, Royal Brompton Hospital, Harrow, London, - - 2013
Individuals of Indian Asian ethnicity living in the U.K. have at least a 50% excess of cardiovascular disease (CVD) mortality compared with European whites, yet there are no validated tools capable of identifying this excess risk. Left ventricular hypertrophy (LVH) is a powerful prognosticator for future CVD events but its ...
Hanke Guy - - 2012
Ferredoxin (Fd), is a small [2Fe-2S] cluster containing protein found in all organisms performing oxygenic photosynthesis. Fd is the first soluble acceptor of electrons on the stromal side of the chloroplast electron transport chain, and as such is pivotal to determining the distribution of these electrons to different metabolic reactions. ...
Wang Xi - - 2012
3-Hydroxypropionic acid (3-HP) is a commercially important platform chemical from which a panel of chemicals can be generated. Klebsiella pneumoniae has been regarded as a promising host strain in glycerol-based 3-HP production for its exceptional ability to metabolize glycerol. Since the glycerol dissimilation mechanism governs the carbon flux distribution from ...
Page Louise R - - 2012
Two of the three major gastropod clades with feeding larvae are sister groups and larval morphogenesis for members of these clades, the Caenogastropoda and Heterobranchia, has been well studied. The third clade, the Neritimorpha, has an unstable phylogenetic position and little is known about development of their planktotrophic larvae. Information ...
Miller Florence - - 2012
The brain and meningeal spaces are protected from bacterial invasion by the blood brain barrier, formed by specialized endothelial cells and tight intercellular junctional complexes. However, once in the bloodstream, N. meningitidis crosses this barrier in about 60% of the cases. This highlights the particular efficacy with which N. meningitidis ...
Evans Sarah - - 2012
The periosteum, a thin, fibrous tissue layer covering most bones, resides in a dynamically loaded environment. The periosteum also provides a niche for mesenchymal stem cells. The mechanics of periosteum vary greatly between species and anatomical locations, indicating the specialized role of periosteum as bone's bounding membrane. Furthermore, periosteum exhibits ...
Brenchley Rachel - - 2012
Bread wheat (Triticum aestivum) is a globally important crop, accounting for 20 per cent of the calories consumed by humans. Major efforts are underway worldwide to increase wheat production by extending genetic diversity and analysing key traits, and genomic resources can accelerate progress. But so far the very large size ...
Francis H - - 2012
BACKGROUND: The present study aimed to conduct a preliminary investigation of the validity and reliability of a short dietary questionnaire designed to assess dietary intake of saturated fat and free sugars. METHODS: Forty students at Macquarie University, aged 17-46 years, completed the Dietary Fat and free Sugar - Short Questionnaire (DFS), a full-length ...
Martin Olivier Richard - - 2012
Phosphatidyl inositol mannosides (PIMs) are constituents of the mycobacterial cell wall; these glycolipids are known to exhibit potent inhibitory activity toward the LPS-induced production of cytokines by macrophages, and therefore have potential as antiinflammatory agents. In order to simplify the structure of these compounds and facilitate their synthesis, heterocyclic analogs ...
Munsterhjelm C - - 2012
Health in relation to tail-biting behaviour was investigated on a problem farm. Quartets (n = 16) of age- and gender-matched fattening pigs including a tail biter (TB, n = 16), a victim (V, n = 16), a control in the same pen (Ctb, n = 10) and a control in ...
Köhlitz Torsten - - 2012
OBJECTIVE: To assess anatomical risk factors in patients after lateral patellar dislocation (LPD) and controls using MRI. METHODS: MR images of 186 knees after LPD and of 186 age- and gender-matched controls were analysed. The presence of trochlear dysplasia was assessed by evaluation of trochlear inclination, facet asymmetry, and trochlear ...
Burada Florin - - 2012
Epidemiological and experimental evidence indicates chronic inflammation as a risk factor for colorectal cancer. We investigated whether IL-1B -511C>T (rs16944), IL-1B +3954C>T (rs1143634) and IL1-RN +2018T>C (rs419598) cytokine polymorphisms are correlated with colorectal cancer. Blood samples were obtained from 377 Romanian subjects: 144 patients with sporadic colorectal cancer and 233 ...
Buhr H - - 2012
For the first time the absolute photon mass energy-absorption coefficient of air in the energy range of 10 to 60 keV has been measured with relative standard uncertainties below 1%, considerably smaller than those of up to 2% assumed for calculated data. For monochromatized synchrotron radiation from the electron storage ring ...
Pleguezuelos E M - - 2012
Context The PRACTICUM Institute has developed large-scale international programs of on-line continuing professional development (CPD) based on self-testing and feedback using the Practicum Script Concordance Test© (PSCT). Aims To examine the psychometric consequences of pooling the responses of panelists from different countries (composite panels) and the effect of increasing composite ...
Jiao Hanwei - - 2012
Avian influenza has emerged as a devastating disease and may cross species barrier and adapt to a new host, causing enormous economic loss and great public health threats, and non-structural protein 1 (NS1) is a multifunctional non-structural protein of avian influenza virus (AIV) that counters cellular antiviral activities and is ...
Kim Zisun - - 2012
ABSTRACT: BACKGROUND: Skin-sparing mastectomy (SSM) and latissimus dorsi (LD) flap immediate breast reconstruction (IBR) is a tailored surgical procedure. The surgical and patient-reported outcome (PRO) of SSM and LD IBR were assessed. METHODS: Retrospective data of 146 SSMs performed by a single surgeon was reviewed. Among patients included in the ...
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