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Results 451 - 500 of 2474
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Ruiz-Espinosa H - - 2012
Multiple-pass UHPH was used for reducing microbial population of both indigenous spoilage microflora in whole raw milk and a baroresistant pathogen (Staphylococcus aureus) inoculated in whole sterile milk to define pasteurization-like processing conditions. Response surface methodology was followed and multiple response optimization of UHPH operating pressure (OP) (100, 175, 250 ...
Andersson Roland E - - 2012
BACKGROUND: Avoiding mortality is the ultimate goal when managing patients with suspected appendicitis. Previous studies have shown high mortality after negative appendectomy. This national cohort study analyzes short- and long-term mortality after appendectomy in relation to appendectomy diagnosis, age, co-morbidity, surgical method, hospital volume, and time period. METHOD: A total ...
Spigelman Mel - - 2012
To the Editor: The study by Gler et al. (June 7 issue)(1) provides a needed reminder regarding the development pipeline for drugs for tuberculosis and multidrug-resistant (MDR) tuberculosis.(2) Delamanid with bedaquiline is increasing the potential for improving current regimens for tuberculosis. In their editorial in the same issue, Chaisson and ...
Zhang Feng - - 2012
Gene delivery takes advantage of cellular mechanisms to express gene products and is an efficient way to deliver them into cells, influencing cellular behaviours and expression patterns. Among the delivery methods, viral vectors are applied due to their high efficiency. Two typical viral vectors for gene delivery include lentiviral vector ...
Karrer Sigrid - - 2012
Skin rejuvenating effects of photodynamic therapy (PDT) for photoaged skin has been well-documented in several clinical trials. Different photosensitizers (5-aminolevulinic acid, methyl aminolevulinate) and diverse light sources (light-emitting diodes, lasers, intense pulsed light) have been used with promising results. An improvement of lentigines, skin roughness, fine lines and sallow complexion ...
Duarte Sonia - - 2012
Cancer stem cells (CSCs) represent a minor population of self-renewing cancer cells that fuel tumor growth. As CSCs are generally spared by conventional treatments, this population is likely to be responsible for relapses that are observed in most cancers. In the present work, we analyzed the preventive efficiency of a ...
Yang Lily P H - - 2012
Axitinib is a new inhibitor of vascular endothelial growth factor (VEGF) receptors 1-3, with greater inhibition potency than existing VEGF receptor inhibitors sunitinib, sorafenib and pazopanib. In a pivotal phase III trial in patients with advanced renal cell carcinoma that had progressed despite first-line therapy, axitinib 5 mg twice daily significantly ...
Huser Sonja - - 2012
The assembly of clathrin/AP-1-coated vesicles on the trans-Golgi network and endosomes is much less studied than of clathrin/AP-2 vesicles at the plasma membrane for endocytosis. In vitro, AP-1 association to protein-free liposomes had been shown to require phosphoinositides, Arf1•GTP, and additional cytosolic factor(s). We have purified an active fraction from ...
Cole Scott N - - 2012
Studies exploring mental time travel commonly use cue-word paradigms to elicit past and future autobiographical events. However, the effect of trial duration (how long participants are allowed to describe events) on the relationship between episodic and nonepisodic detail and episodic specificity (i.e., whether longer durations increase event specificity) has not ...
Managò Francesca - - 2012
RATIONALE: Metabotropic glutamate mGlu receptors 5 (mGluR5) receptors are abundant in corticolimbic circuitry where they modulate glutamate and dopamine signal transduction. OBJECTIVES: In this study, we explored the hypothesis that mGluR5 antagonist, (2-methyl-6-(phenylethynyl)pyridine hydrochloride) (MPEP), facilitates dopamine-dependent effects on memory and motor functions. METHODS: To this aim, we examined the ...
Mędrek Krzysztof - - 2012
Among many alterations within the TP53 gene the rs1042522 (C72G, p.Pro72Arg) has been associated with numerous cancers , however the results differ between populations for opposite Pro or Arg alleles. Similar thus inconclusive results are observed in ovarian cancer, which may suggest that the rs1042522 does not influence ovarian carcinogensis ...
Taniguchi Yoshinori - - 2012
Enthesitis, defined as the inflammation of the origin and insertion of ligaments, tendons, aponeuroses, annulus fibrosis, and joint capsules, is a hallmark of spondyloarthritis (SpA). New imaging techniques including magnetic resonance imaging (MRI), ultrasonography, and positron emission tomography with computed tomography using (18)F-fluorodeoxyglucose capable of detecting morphological and metabolic abnormalities ...
Rummel Seth - - 2012
Triple-negative breast cancer (TNBC) is characterized by aggressive behavior and poor prognosis. While >50 % of patients with inherited BRCA1 mutations have TNBC, the prevalence of BRCA1 mutations in patients with TNBC remains unclear. Deciphering the relationship between BRCA1 and TNBC is critical to understanding the etiology of TNBC, leading to ...
Scalone Luciana - - 2012
PURPOSE: To assess the performance of the EQ-5D-5L version compared with the standard EQ-5D-3L in a clinical setting targeted at patients with chronic hepatic diseases (CHDs). METHODS: We introduced the 5L descriptive system into a cost-of-illness study involving patients with different CHDs. The patients completed a questionnaire including the two ...
Nabavi Seyed Fazel - - 2012
Methyl-3-O-methyl gallate (M3OMG) is a rare natural product that showed promising in vitro antioxidant activities. In this study, the protective role of synthetic M3OMG against sodium fluoride (NaF)-induced oxidative stress in rat brain was evaluated. Animals were treated with either M3OMG (10 and 20 mg/kg i.p.), vitamin C (10 mg/kg i.p.) as ...
Miera Oliver - - 2012
To the Editor: The selection of controls in observational studies is challenging. The propensity-score methods use baseline variables as predictors and group assignment as the outcome.(1) The resulting model is applied to identify controls whose probability of receiving the intervention is close to that of patients who do receive the ...
Tewari Angela - - 2012
Long wavelength UVA1 (340-400 nm) is the main component of terrestrial UVR and is increasingly used in skin phototherapy. Its damage to critical biomolecules such as DNA has been widely attributed to its ability to generate reactive oxygen species (ROS) via other chromophores. However recent studies in vitro and in ...
La Quang Ngoc - - 2012
Bus provides a main mode of public transport in Vietnam, but the risk of road traffic crash for bus drivers is unknown. This retrospective study estimated the crash prevalence among bus drivers in Hanoi, Vietnam, and identified driver characteristics affecting their crashes. Information on bus crashes for the period 2006-2009 ...
Levic K - - 2012
BACKGROUND: Transanal endoscopic microsurgery (TEM) allows locally complete resection of early rectal cancer as an alternative to conventional radical surgery. In case of unfavourable histology after TEM, or positive resection margins, salvage surgery can be performed. However, it is unclear if the results are equivalent to primary treatment with total ...
O'Mahony Aoife M - - 2012
PURPOSE: Development of RNA interference based therapeutics for neurological and neurodegenerative diseases is hindered by a lack of non-viral vectors with suitable properties for systemic administration. Amphiphilic and cationic cyclodextrins (CD) offer potential for neuronal siRNA delivery. We aimed to improve our CD-based siRNA formulation through incorporation of a polyethyleneglycol ...
Navia Denise - - 2012
The coconut mite (CM), Aceria guerreronis Keifer, has spread to most coconut production areas worldwide and it has been considered one of the most notorious and important pests of coconut fruits in many countries. Although CM has been reported to damage coconuts for over 40 years in the Americas and Africa ...
Tyrell Ede - - 2012
OBJECTIVE: To assess the socioeconomic impact of lymphatic filariasis (LF) in Guyana. METHODS: Observational, cross-sectional study of 50 persons with chronic LF attending the Filariasis Clinic who were selected as the cases; and 50 persons with chronic skin conditions but no chronic LF, attending the Skin Clinic who were selected ...
Pondé Robério A A - - 2012
During hepatitis B virus (HBV) infection, at least four antigen-antibody systems are observed: HBsAg and anti-HBs; preS antigen and anti-preS antibody; HBcAg and anti-HBc; and HBeAg and anti-HBe. Through the examination of these antigen-antibody systems, hepatitis B infection is diagnosed and the course of the disorder may be observed. Although ...
Blutstein Tamara - - 2012
In utero exposure to cigarette smoke has severe consequences for the developing fetus, including increased risk of birth complications and behavioral and learning disabilities later in life. Evidence from animal models suggests that the cognitive deficits may be a consequence of in utero nicotine exposure in the brain during critical ...
Thompson David W J - - 2012
A new data set of middle- and upper-stratospheric temperatures based on reprocessing of satellite radiances provides a view of stratospheric climate change during the period 1979-2005 that is strikingly different from that provided by earlier data sets. The new data call into question our understanding of observed stratospheric temperature trends ...
Ren Xiaochen - - 2012
A thermistor-transistor integrated organic temperature sensor is reported. By inserting a thin layer of silver nanoparticles the organic thermistor shows strong temperature sensitivity and the total dynamic range of sensing is around 10 bits which is larger than most organic temperature sensors. The measuring temperature range is from 20 to ...
Yamamoto Mika - - 2012
Intracellular signaling pathways between the mitochondria and the nucleus are important in both normal and abnormal development in plants. The homeotic transformation of stamens into pistil-like structures (a phenomenon termed pistillody) in cytoplasmic substitution (alloplasmic) lines of bread wheat (Triticum aestivum) has been suggested to be induced by mitochondrial retrograde ...
Tulkin Steven R - - 2012
The authority to prescribe could differentiate psychologists from other non-physicians in primary care, achieving a significant step for the growth of our profession. Psychologists are currently prescribing in primary care settings in a number of public service venues, as well as medical school training facilities. In this Special Section of ...
Lee Richard - - 2012
The relationship between rectal dose distribution and the incidence of late rectal complications following external-beam radiotherapy has been previously studied using dose-volume histograms or dose-surface histograms. However, they do not account for the spatial dose distribution. This study proposes a metric based on both surface dose and distance that can ...
Livak-Dahl Eric - - 2012
Measurement of a solution's viscosity is an important analytic technique for a variety of applications including medical diagnosis, pharmaceutical development, and industrial processing. The use of droplet-based (e.g., water-in-oil) microfluidics for viscosity measurements allows nanoliter-scale sample volumes to be used, much smaller than those either in standard macro-scale rheometers or ...
Agas Dimitrios - - 2012
Bone microenvironment is a complex dynamic equilibrium between osteoclasts and osteoblasts and is modulated by a wide variety of hormones and osteocyte mediators secreted in response to physiological and pathological conditions. The rate of remodeling involves tight coupling and regulation of both cells population and is regulated by a wide ...
Wright L - - 2012
Canada has a marked shortfall between the supply and demand for kidneys for transplantation. Median wait times for deceased donor kidney transplantation vary from 5.8 years in British Columbia, 5.2 years in Manitoba and 4.5 years in Ontario to a little over 2 years in Quebec and Nova Scotia. Living donation provides a viable ...
Kumar R - - 2012
In recent years, reaction of inexpensive and abundantly available alcohols (C-OH) with unactivated nucleophilic coupling partners (C-H), leading to the construction of the C-C bond, has emerged as one of the vital strategies since it is an atom-economical and environmentally benign approach with water as the by-product. Various transition metal-catalyzed ...
Durmuş Tekir Saliha D - - 2012
Infectious diseases comprise some of the leading causes of death and disability worldwide. Interactions between pathogen and host proteins underlie the process of infection. Improved understanding of pathogen-host molecular interactions will increase our knowledge of the mechanisms involved in infection, and allow novel therapeutic solutions to be devised. Complete genome ...
Vijayakumari Anupa A - - 2012
Narcolepsy is a rare, chronic sleep disorder characterized by excessive daytime sleepiness, cataplexy and other manifestations of dissociated rapid eye movement in sleep. We assessed the utility of transcranial magnetic stimulation (TMS) as an objective tool to elucidate the cortical excitability changes and also to analyze its role in assessing ...
- - 2012
To the Editor: Zhuang et al. (Sept. 6 issue)(1) report HIF2A somatic mutations in two patients with paraganglioma. In a recent transcriptome analysis of a large number of pheochromocytomas and paragangliomas, we identified 16 sporadic tumors with a transcription signature similar to that of VHL-mutated tumors.(2) There was somatic inactivation ...
Nishimura Tomoki - - 2012
We have developed a simple and robust fluorescence based boronic-acid molecular sensor for determining the concentration of fluoride in water at environmentally significant levels. The simplicity of the method and the ability to measure fluoride in water between 0.1 and 1.5 ppm is particularly noteworthy given the WHO requirements for ...
Tang-Feldman Yajarayma J - - 2012
Multiple studies suggest an association between cytomegalovirus (CMV) infection and atherogenesis; however, the molecular mechanisms by which viral infection might exacerbate atherosclerosis are not well understood. Aortas of MCMV-infected and uninfected Apo E knockout (KO) mice were analyzed for atherosclerotic lesion development and differential gene expression. Lesions in the infected ...
Whittington Hannah J - - 2012
PURPOSE: Clinical and experimental investigations demonstrated that metformin, a widely used anti-diabetic drug, exhibits cardioprotective properties against myocardial infarction. Interestingly, metformin was previously shown to increase the expression of PGC-1α a key controller of energy metabolism in skeletal muscle, which is down-regulated in diabetic conditions. We hypothesized that chronic treatment ...
Flohil Sophie C - - 2012
Basal cell carcinoma (BCC) incidence rates are increasing. From 1973 to 2009, data on all first histologically confirmed BCCs were gained from the Eindhoven Cancer Registry to estimate trends in patient-based BCC incidence rates by sex, age group, and site in the southeast Netherlands. Trends in European age-standardized rates and ...
Lackner Simone - - 2012
BACKGROUND: During segmentation of the zebrafish embryo, inside-out signaling activates Integrin α5, which is necessary for somite border morphogenesis. The direct activator of Integrin α5 during this process is unknown. One candidate is Rap1b, a small monomeric GTPase implicated in Integrin activation in the immune system. RESULTS: Knockdown of rap1b, ...
Suzuki Fumitaka - - 2012
AIM: The aims of this study are to assess the antiviral effects, safety and telaprevir (TVR) pharmacokinetics in two cohorts given TVR every 8 h (q8h) at doses of 500 mg and 750 mg with peginterferon-α-2b and ribavirin in chronic hepatitis C patients. METHODS: Twenty chronic hepatitis C (HCV) patients with genotype 1b ...
Ilić Katarina - - 2012
Osteoporosis and hypertension are two frequent diseases among the aging population that share a similar etiopathology and often coexist. Moreover, treatment of hypertension affects bone mineral density and, therefore, can worsen osteoporosis. This narrative review considers the influence of the main etiologic factors that contribute to the development of hypertension ...
Huang Xiaoqiang - - 2012
The structure-based design of protein-ligand interfaces with respect to different small molecules is of great significance in the discovery of functional proteins. By statistical analysis of a set of protein-ligand complex structures, it was determined that water-mediated hydrogen bonding at the protein-ligand interface plays a crucial role in governing the ...
Atreya Hanudatta S - - 2012
A newly implemented G-matrix Fourier transform (GFT) (4,3)D HC(C)CH experiment is presented in conjunction with (4,3)D HCCH to efficiently identify (1)H/(13)C sugar spin systems in (13)C labeled nucleic acids. This experiment enables rapid collection of highly resolved relay 4D HC(C)CH spectral information, that is, shift correlations of (13)C-(1)H groups separated ...
Pasold Juliane - - 2012
We here describe the novel high bone mass phenotype in STR/ort mice that leads to increased bone masses of cortical and trabecular bone and is associated with elevated osteoblast activity and impaired osteoclast function alike. Comparison of STR/ort and C57BL/6 mice reveals an increase in trabecular bone volumes of the ...
Binagwaho Agnes - - 2012
More than 390 000 children are newly infected with HIV each year, only 28 per cent of whom benefit from early infant diagnosis (EID). Rwanda's Ministry of Health identified several major challenges hindering EID scale-up in care of HIV-positive infants. It found poor counseling and follow-up by caregivers of HIV-exposed infants, ...
Hayden Dana M - - 2012
BACKGROUND: Ileostomy creation has complications, including rehospitalization for fluid and electrolyte abnormalities. Although studies have identified predictors of this morbidity, readmission rates remain high. METHODS: The researchers conducted a retrospective chart review of all patients with ileostomy creation at a tertiary institution from January 2008 to June 2011. RESULTS: One ...
Wang Wei - - 2012
IgA nephropathy is one of the most common glomerulonephritis throughout the world, which is thought to be the multifactorial complex diseases, with genetic and environmental factors contributing to this disease. The failure of replicating the single genes in previous association studies may be of that the gene-gene interaction might have ...
Wang D - - 2012
The objective of this work was to evaluate the dosimetry of tungsten eye shields for use with kilovoltage X-ray beam treatments. The eye shields, originally designed for megavoltage electron beams, were made of 2 mm tungsten thickness and inside diameters of 11.6 and 15.0 mm with optional aluminium caps of 0.5 and ...
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