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Li Yue Y Technology R&D Team, Toronto Rehabilitation Institute, 550 University Avenue, 13th floor, Toronto, ON M5G 2A2, Canada. - - 2013
Walking outdoors is often difficult or impossible for many seniors and people with disabilities during winter. We present a novel approach for conducting winter accessibility evaluations of commonly used pedestrian facilities, including sidewalks, street crossings, curb ramps (curb cuts and dropped curbs), outdoor stairs and ramps, building and transit entrances, ...
Park Young-Ho YH Disease Model Research Laboratory, Aging Research Center , Korea Research Institute of Bioscience and Biotechnology, Daejeon, - - 2013
Coupled responses of mutated K-ras and oxidative stress are often an important etiological factor in non-small-cell lung cancer (NSCLC). However, relatively few studies have examined the control mechanism of oxidative stress in oncogenic K-ras-driven NSCLC progression. Here, we studied whether the redox signaling pathway governed by peroxiredoxin I (Prx I) ...
Sanchez Washington Y - - 2013
ABSTRACT. Ultraviolet radiation from solar exposure is a key extrinsic factor responsible for premature skin aging (i.e., photo-aging). Recent advances using in vivo multiphoton tomography (MPT) demonstrate the efficacy of this approach to assess intrinsic and extrinsic skin aging as an alternative to existing invasive techniques. In this study, we ...
Leece Pamela P Public Health and Preventive Medicine Residency Program, University of Toronto, Toronto, Ontario, - - 2013
Among inner-city populations in Canada, the use of crack cocaine by inhalation is prevalent. Crack smoking is associated with acute respiratory symptoms and complications, but less is known about chronic respiratory problems related to crack smoking. There is also a gap in the literature addressing the management of respiratory disease ...
Garvin Eugenia E Department of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. - - 2013
Vacant land is a significant economic problem for many cities, but also may affect the health and safety of residents. In order for community-based solutions to vacant land to be accepted by target populations, community members should be engaged in identifying local health impacts and generating solutions. We conducted 50 ...
Chang Wei-Chin WC Department of Pathology, Mackay Medicine, Nursing, and Management College, New Taipei City, - - 2013
The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is a unique variant of PTC that is characterized by extensive lymphovascular invasion of tumor cells in a background of lymphocytic thyroiditis. The lymphatic emboli contain tumor cells as well as macrophages, but the recruitment of these macrophages is not well ...
Burke Darlene A DA Kentucky Spinal Cord Injury Research Center, Department of Neurological Surgery, University of Louisville, Louisville, Kentucky, USA. - - 2013
The development of successful treatments for humans after traumatic brain or spinal cord injuries (TBI and SCI, respectively) requires animal research. This effort can be hampered when promising experimental results cannot be replicated because of incorrect data analysis procedures. To identify and hopefully avoid these errors in future studies, the ...
Chen Jianquan J Department of Medicine, Washington University School of Medicine, St Louis, MO 63131, - - 2013
Genetic studies in the mouse have demonstrated multiple roles for β-catenin in the skeleton. In the embryo, β-catenin is critical for the early stages of osteoblast differentiation. Postnatally, β-catenin in mature osteoblasts and osteocytes indirectly suppresses osteoclast differentiation. However, a direct role for β-catenin in regulating osteoblast number and/or function ...
Veneman Carrie E CE Department of Hearing and Speech Sciences, University of Maryland, College Park, Maryland 20742, - - 2013
The purpose of this study was to determine the effect of measurement time of day on speech recognition in noise and the extent to which time-of-day effects differ with age. Older adults tend to have more difficulty understanding speech in noise than younger adults, even when hearing is normal. Two ...
Maruyama Takamitsu T Department of Biomedical Genetics, Center for Oral Biology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, - - 2013
Human genetic analysis has recently identified Gpr177 as a susceptibility locus for bone mineral density and osteoporosis. Determining the unknown function of this gene is therefore extremely important to furthering our knowledge base of skeletal development and disease. The protein encoded by Gpr177 exhibits an ability to modulate the trafficking ...
Sherman Eric J EJ Department of Medicine, Memorial Sloan-Kettering Cancer Center , New York, NY 10065, USA. - - 2013
Historically, systemic therapy for radioactive iodine (RAI)-refractory thyroid cancer has been understudied. Available drugs have modest efficacy. Romidepsin is a histone deacetylase inhibitor with potent antitumor effects both in vitro and in vivo. In thyroid cancer cell lines, romidepsin increases expression of both thyroglobulin and the sodium iodide symporter messenger ...
Landolt Nadia Kancheva NK The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Bangkok, - - 2013
Effective contraception has been widely promoted for HIV-positive women. However, there are limited data on the interactions between combined hormonal contraceptives and nonnucleoside reverse transcriptase inhibitors . This study assessed the steady-state contraceptive effectiveness and safety of combined oral contraceptive (COC) containing 0.150 mg desogestrel /0.030 mg ethinyl estradiol with ...
He Yi-Yu YY Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, - - 2013
High-mobility group box 1 (HMGB1), a nuclear protein, has been recently reported to attenuate cardiac remodeling after myocardial infarction (MI). This study was designed to investigate whether this effect could be strengthened by local intramyocardial injection of HMGB1 along with a novel Dex-PCL-HEMA/PNIPAAm hydrogel and ascertain its possible mechanism of ...
Navaratnam Vidya V Division of Epidemiology and Public Health, University of Nottingham, Nottingham, England. - - 2013
The lack of mandatory clinical registries for idiopathic pulmonary fibrosis (IPF) has meant a reliance on routine clinical data to provide trends in disease incidence. Death certificate and primary care data suggest that the incidence of IPF has increased in the United Kingdom at a rate of approximately 5% per ...
Deobagkar-Lele Mukta M Department of Biochemistry, Indian Institute of Science, Bangalore, - - 2013
Thymic atrophy is known to occur during infections; however, there is limited understanding of its causes and of the cross-talk between different pathways. This study investigates mechanisms involved in thymic atrophy during a model of oral infection by Salmonella enterica serovar Typhimurium (S. typhimurium). Significant death of CD4(+) CD8(+) thymocytes, ...
Ehrhardt H H Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, - - 2013
In polychemotherapy protocols, that is for treatment of neuroblastoma and Ewing sarcoma, Vinca alkaloids and cell cycle-arresting drugs are usually administered on the same day. Here we studied whether this combination enables the optimal antitumour effects of Vinca alkaloids to be manifested. Vinca alkaloids were tested in a preclinical mouse ...
Young Michael E ME Department of Psychology, Kansas State University, 492 Bluemont Hall, Manhattan, KS 66506-5302, USA. - - 2013
A first-person shooter video game was adapted for the study of choice between smaller sooner and larger later rewards. Participants chose when to fire a weapon that increased in damage potential over a short interval. When the delay to maximum damage was shorter (5-8 s), people showed greater sensitivity to ...
Smith Jill P JP Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA. - - 2013
There is an unmet need for safe and effective medicines to treat children with Crohn's disease. Recently, investigations have shown an association between endogenous opioid peptides and inflammatory cells. The aims of this study were to evaluate the safety and tolerability of an opioid antagonist, naltrexone, in children with moderate ...
McCarthy Fergus P FP Department of Obstetrics & Gynaecology, Anu Research Centre, University College Cork, Cork, - - 2013
Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors expressed in trophoblasts, which regulate both cell differentiation and proliferation. In recent years, evidence has linked PPARs to playing an integral role in pregnancy; specifically, PPAR-β and PPAR-γ have been shown to play an integral role in placentation, with PPAR-γ additionally ...
Rohacs Tibor T UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA. - - 2013
Transient receptor potential melastatin 7 (TRPM7) is a multifunctional ion channel playing crucial roles during development. TRPM7 is a member of the highly diverse TRP ion channel family. Most TRP channels are regulated by membrane phospholipids, especially phosphoinositides. In this issue of the British Journal of Pharmacology, Qin et al. ...
Finlen Copeland C Ashley CA Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. - - 2013
Quality of life (QOL) is an important but understudied outcome after lung transplantation. Previous cross-sectional, single-center studies suggest improved QOL, but few prior longitudinal multicenter data exist regarding the effect of transplantation on the patient’s QOL. We hypothesized that lung transplantation confers a 1-year QOL benefit in both physical and ...
Thompson George R GR Department of Medical Microbiology and Immunology, Coccidioidomycosis Serology Laboratory, University of California-Davis, Davis, CA 95616, USA. - - 2013
In a patient with positive serum serology for coccidioidomycosis, the differential diagnosis of concurrent pleural effusions can be challenging. We, therefore, sought to clarify the performance characteristics of biochemical, serologic, and nucleic-acid-based testing in an attempt to avoid invasive procedures. The utility of adenosine deaminase (ADA), coccidioidal serology, and polymerase ...
Aldrich Thomas K TK Pulmonary Medicine Division, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY 10467, USA. - - 2013
Few longitudinal studies characterize firefighters’ pulmonary function. We sought to determine whether firefighters have excessive FEV(1) decline rates compared with control subjects. We examined serial measurements of FEV(1) from about 6 months prehire to about 5 years posthire in newly hired male, never smoking, non-Hispanic black and white firefighters, hired ...
Newcomb Michael E ME Department of Medical Social Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. - - 2013
Men who have sex with men (MSM) account for more than half of new HIV infections each year, and young black MSM experience the highest incidence rates. Black MSM have not been found to engage in more HIV risk behaviors, and it has been proposed that sexual network factors (racially ...
Kahle Erin M EM Department of Epidemiology, University of Washington, Seattle, WA 98104, USA. - - 2013
Heterosexual HIV-1-serodiscordant couples are increasingly recognized as an important source of new HIV-1 infections in sub-Saharan Africa. A simple risk assessment tool could be useful for identifying couples at highest risk for HIV-1 transmission. Using data from 3 prospective studies of HIV-1-serodiscordant couples from 7 African countries and standard methods ...
Meyer-Rath Gesine G Center for Global Health and Development, Boston University, Boston, MA, USA. - - 2013
Few studies have compared hospitalizations before and after antiretroviral therapy (ART) initiation in the same patients. We analyzed the cost of hospitalizations among 3906 adult patients in 2 South African hospitals, 30% of whom initiated ART. Hospitalizations were 50% and 40% more frequent and 1.5 and 2.6 times more costly ...
Levin Phillip D PD Departments of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel. - - 2013
The sterile conditions used when inserting a central venous catheter (CVC) might be thought to decrease the contamination rate of blood cultures taken at CVC insertion; however, a previous retrospective study showed the opposite, that such blood cultures are contaminated more frequently than peripheral venipuncture blood cultures. The current study ...
Katz Pamela M PM Department of Medicine, University of Manitoba, Winnipeg, MB, - - 2013
To evaluate the status of iodine nutrition among pregnant women presenting for routine antenatal care in Toronto, Canada, as determined by the median urine iodine concentration (UIC) of this population. A cross-sectional, observational study was conducted involving 142 pregnant women recruited from four low-risk antenatal outpatient clinics in Toronto, Canada. ...
Tran Huy A HA Department of Clinical Chemistry, Hunter Area Pathology Service, Newcastle, New South Wales, Australia. - - 2013
Hepatitis C virus (HCV) infection is one of the major epidemics afflicting young people in both developed and developing countries. The most common endocrine disorder associated with this infection, especially in conjunction with interferon-α (IFN-α)-based therapy, is thyroid disease (TD). This review examines the development of TD before, during, and ...
Wilson Jayne Louise JL Department of Molecular Biology and Biotechnology, The University of Sheffield , Sheffield, United - - 2013
Carbon monoxide (CO) delivered to cells and tissues by CO-releasing molecules (CO-RMs) has beneficial and toxic effects not mimicked by CO gas. The metal carbonyl Ru(CO)3Cl(glycinate) (CORM-3) is a novel, potent antimicrobial agent. Here, we established its mode of action. CORM-3 inhibits respiration in several bacterial and yeast pathogens. In ...
Rubin Mark N - - 2013
Vascular disease affecting the spinal can cause substantial neurologic morbidity. Several vascular spinal cord ailments present as neurologic emergencies, and should thus be recognizable to the practicing neurologist. We review the epidemiology, presentation, management strategies, and prognosis of various pathologies, including infarction, dural arteriovenous fistula, arteriovenous malformation, cavernous malformation, compressive ...
Sahraian Mohammad Ali - - 2013
Neuromyelitis optica (NMO) is a severe inflammatory demyelinating disease of the central nervous system with distinguishing features from multiple sclerosis. Understanding of clinical presentation, immunopathology, and imaging features has changed during the last decade. The identification of NMO immunoglobulin G and aquaporin 4 as the target antigen in this disease ...
Ciccoto Giuseppe - - 2013
Recognizing stiff person syndrome is clinically important. It is uncommon, characterized by body stiffness associated with painful muscle spasms, and varies in location and severity. It is subdivided into stiff trunk versus stiff limb presentation, and as a progressive encephalomyelitis. Stiff person-type syndrome also reflects a paraneoplastic picture. Most patients ...
Mechtler Laszlo L - - 2013
Spinal cord tumors are uncommon neoplasms that, without treatment, can cause significant neurologic morbidity and mortality. The historic classification of spine tumors is based on the use of myelography with 3 main groups: (1) extramedullary extradural, (2) intradural extramedullary, and (3) intradural intramedullary. This chapter focuses on intramedullary spinal cord ...
Toledano Michel - - 2013
The differential of cervical spondylotic myelopathy (CSM) is broad and includes multiple conditions that can cause and mimic myelopathy. In adults older than 55 years of age, CSM is the most common cause of myelopathy. This article summarizes the pathophysiology, clinical presentation, differential diagnosis, diagnostic evaluation, and natural history of ...
Zhang Shihao - - 2013
Spine trauma is a devastating clinical condition that affects many people annually on a worldwide basis. Management of spinal trauma has become much more surgically oriented with advances in stabilization techniques over the past two decades. The degree of injury to the spinal cord dictates the prognosis of the patient ...
Schwendimann Robert N - - 2013
This review article identifies and describes the clinical manifestations of various metabolic, nutritional, and toxic conditions that result in symptoms of myelopathy and, in some cases, myeloneuropathy. It includes discussions of the clinical pictures that occur secondary to these causes. Familiarity with the clinical symptoms may lead to accurate diagnosis ...
Rezania Kourosh - - 2013
Spinal cord motor neuron diseases affect lower motor neurons in the ventral horn. This article focuses on the most common spinal cord motor neuron disease, amyotrophic lateral sclerosis, which also affects upper motor neurons. Also discussed are other motor neuron diseases that only affect the lower motor neurons. Despite the ...
Beh Shin C - - 2013
Transverse myelitis (TM) includes a pathobiologically heterogeneous syndrome characterized by acute or subacute spinal cord dysfunction resulting in paresis, a sensory level, and autonomic (bladder, bowel, and sexual) impairment below the level of the lesion. Etiologies for TM can be broadly classified as parainfectious, paraneoplastic, drug/toxin-induced, systemic autoimmune disorders, and ...
Flanagan Eoin P - - 2013
Paraneoplastic causes are a rare but important diagnostic consideration when evaluating myelopathy because neurologic symptoms may herald a diagnosis of cancer. Spinal cord MRI findings of longitudinally extensive, symmetric, tract-specific T2-signal changes occasionally with gadolinium enhancement are characteristic. Detection of neural-specific autoantibodies assists in confirming the diagnosis and guides the ...
Sheremata William - - 2013
Many clinical manifestations of multiple sclerosis (MS) may be attributed to spinal cord disease. MS may have classic presentation or a more complex presentation. MS is mainly a relapsing remitting disease, but there is also an insidious form that is progressive, known as primary progressive MS (PPMS). PPMS may not ...
Bican Orhan - - 2013
The spinal cord controls the voluntary muscles of the trunk and limbs and receives sensory input from these areas. It extends from the medulla oblongata to the lower border of the first lumbar vertebra. A basic knowledge of spinal cord anatomy is essential for interpretation of clinical signs and symptoms ...
Strommen Jeffrey A - - 2013
Spasticity is a common component of those with spinal cord dysfunction. Spasticity can lead not only to pain and potential secondary complications such as contracture and pressure sores but also to significant functional impairment. The clinician must identify specific goals of spasticity treatment and assess the potential benefit of spasticity, ...
Korkmaz Asli - - 2013
Nitric oxide (NO) seems to play an important role during renal ischemia/reperfusion (I/R) injury. We investigated whether rutin inhibits inducible nitric oxide synthase (iNOS) and reduces 3-nitrotyrosine (3-NT) formation in the kidneys of rats during I/R. Wistar albino rats were nephrectomized unilaterally and, 2 weeks later, subjected to 45 minutes ...
White Neil J - - 2013
The purpose of this study was to compare the biomechanical properties of locked versus nonlocked lateral fibular bridge plating of comminuted, unstable ankle fractures in a mode of catastrophic failure. We created comminuted Weber C fractures in 8 paired limbs from fresh cadavers. Fractures were plated with either standard or ...
Keogh Jennifer B - - 2013
The Swedish adjustable gastric band VC (SAGB-VC) has been in use in Australia since 2007. We evaluated its efficacy and safety. We retrospectively analyzed the prospective clinical data of patients who received the implant between November 2007 and June 2009 at 3 Australian bariatric centres. In all, 1176 patients (mean ...
Boschi Vladimir - - 2013
There are few surgical approaches for treating humeral shaft fractures. Here we present our results using a subbrachial approach. We conducted a retrospective case series involving patients who had surgery for a humeral shaft fracture between January 1994 and January 2008. We divided patients into 4 groups based on the ...
Saito Aya - - 2013
Cardiac retransplantation remains the most viable option for patients with allograft heart failure; however, careful patient selection is paramount considering limited allograft resources. We analyzed clinical outcomes following retransplantation in an academic, tertiary care institution. Between 1981 and 2011, 593 heart transplantations, including 22 retransplantations were performed at our institution. ...
Oveland Nils Petter - - 2013
Although thoracic ultrasonography accurately determines the size and extent of occult pneumothoraces (PTXs) in spontaneously breathing patients, there is uncertainty about patients receiving positive pressure ventilation. We compared the lung point (ie, the area where the collapsed lung still adheres to the inside of the chest wall) using the two ...
Kang Mee Joo - - 2013
Despite its wide use, catheter tract recurrence after percutaneous biliary drainage (PBD) is rarely reported. However, one recent large-scale study reported a catheter tract recurrence rate as high as 5.2 % in patients with perihilar or distal bile duct cancer. We report on our 20 years of experience with catheter ...
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