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Xu Hui - - 2012
UVB radiation stimulates the production of vitamin D and also has immunosuppressive effects. Vitamin D is also known to alter immunological function. Thus, a relevant question is whether vitamin D is a mediator of the immunological effects of UVB. In this issue, Schwarz et al. have addressed this issue and ...
Megerle K - - 2012
The purpose of this study was to assess the clinical and radiological outcomes of dorsal intercarpal ligament capsulodesis for the treatment of static scapholunate instability at a minimum follow-up of four years. A total of 59 patients who underwent capsulodesis for this condition were included in a retrospective analysis after ...
Kondo Shigetada - - 2012
Muscle atrophy caused by unloading stress is a serious problem in bed rest patients or astronauts. In our previous studies, we revealed that induction and activation of ubiquitin ligase Cbl-b played an important role in skeletal muscle atrophy caused by unloading stress. Under muscle atrophy conditions, Cbl-b interacted with and ...
Kutcher Matthew E - - 2012
Tissue injury leads to the release of DAMPs (damage-associated molecular patterns) that may drive a sterile inflammatory response; however, the role of extracellular histone levels after traumatic injury remains unexplored. We hypothesized that extracellular histone levels would be increased and associated with poor outcomes after traumatic injury. In this prognostic ...
Jameson S S - - 2012
Despite excellent results, the use of cemented total hip replacement (THR) is declining. This retrospective cohort study records survival time to revision following primary cemented THR using the most common combination of components that accounted for almost a quarter of all cemented THRs, exploring risk factors independently associated with failure. ...
Kutlu Yasemin - - 2012
In this study, the reliability, validity, and psychometric properties of the Turkish version of the Fraboni Scale of Ageism were assessed. The psychometric properties of the scale were studied through a descriptive and correlational design. The study sample consisted of 231 healthy people living in the Marmara region of Turkey. ...
Hu Yong - - 2012
Objective: To investigate the stability and three-dimensional movements of the atlantoaxial joint after artificial atlanto-odontoid joint (AAOJ) arthroplasty by comparing with a conventional method.Methods: After anterior decompression, 24 human cadaveric spinal specimens of C0-C3 were randomly divided into two groups: Group A receiving artificial AAOJ arthroplasty; Group B experiencing anterior ...
Bae-Harboe Yoon-Soo Cindy - - 2012
Cutaneous pigmentation or skin color is the body's natural protection against sun-induced damage. Skin color is determined primarily by melanin, a biopolymer that is synthesized within epidermal melanocytes, packaged in cellular organelles called melanosomes, and then dispersed to neighboring keratinocytes. The process of melanogenesis involves numerous molecules and intracellular pathways ...
Krieger Andrew R - - 2012
In pediatric trauma patients, adult triage criteria that use mechanism of injury (MOI) have been shown to result in overactivation of trauma teams. Anatomy- and physiology-based (APB) triage criteria have been recommended to improve the accuracy of trauma activations. At our Level 1 academic tertiary pediatric trauma referral center, we ...
Gulotta L V - - 2012
Reverse total shoulder replacement (RTSR) depends on adequate deltoid function for a successful outcome. However, the anterior deltoid and/or axillary nerve may be damaged due to prior procedures or injury. The purpose of this study was to determine the compensatory muscle forces required for scapular plane elevation following RTSR when ...
Macauley Robert - - 2012
With more than 80 000 patients in the United States on waiting lists for a kidney-and more than 100 000 patients beginning treatment for end-stage renal disease each year-transplant programs must evaluate potential recipients in a fair and efficient manner. To this end, certain "absolute exclusion criteria" have been proposed ...
Brunetti O - - 2012
This double-blind randomized controlled study aims at determining the effect of repeated muscle vibration (rMV) on explosive and reactive leg power and on knee laxity of female volleyball players. Eighteen voluntary volleyball athletes, belonging to the same senior regional level team (age=22.7±3 years, height=180.3 ± 5 cm, mass=64±4 kg) were ...
Cahoon William D - - 2012
To review available evidence about the safety and efficacy of alemtuzumab for induction of immunosuppression in heart transplant recipients. Searches of MEDLINE, EMBASE, and Cochrane databases were conducted. Key search terms included alemtuzumab, Campath-1H, CD52, lymphocyte, cytolytic, induction, immunosuppression, rejection, and cardiac transplantation. Additional pertinent data were identified through a ...
Stähli C - - 2012
A 75 years old man is suffering from recurrent seizures since several years. The seizures start with vegetative symptoms including tingling sensations, followed by a deep feeling of eternity and happiness. In one third of the cases he looses consciousness completely. Several workups have failed to reveal a diagnosis. An ...
Zhao Chun-Mei - - 2012
: The chemokine monocyte chemoattractant protein-1 (MCP-1) has been shown to contribute to neuropathic pain. However, whether MCP-1 is involved in the development of morphine antinociceptive tolerance is incompletely understood. : Morphine antinociceptive tolerance was induced by intrathecal administration of 15 μg of morphine daily for 7 days. Immunohistochemistry was ...
McNicholas M J - - 2012
We continued a prospective longitudinal follow-up study of 53 remaining patients who underwent open total meniscectomy as adolescents and who at that time had no other intra-articular pathology of the knee. Their clinical, radiological and patient-reported outcomes are described at a mean follow-up of 40 years (33 to 50). The ...
Reif K - - 2012
Cancer-related fatigue, a subjective feeling of a distinctive physical, emotional and/or cognitive tiredness, is a common phenomenon in patients with cytotoxic chemotherapy or radiotherapy. Research on cancer-related fatigue has been intensified in the last decade. The objective of this work was to give an overview of the effectiveness of non-pharmacological ...
Clark D A - - 2012
Ensuring correct rotation of the femoral component is a challenging aspect of patellofemoral replacement surgery. Rotation equal to the epicondylar axis or marginally more external rotation is acceptable. Internal rotation is associated with poor outcomes. This paper comprises two studies evaluating the use of the medial malleolus as a landmark ...
Eckle T - - 2012
A 25-year old female immigrant from Kosovo living in Switzerland for three years complained of intermittent atypical chest pain and shortness of breath for three months. The patient was febrile (38.4 °C) and had a regular tachycardia of 120/min and a blood pressure of 105/65 mmHg. The ECG showed deep symmetric ...
Holmboe Eric S - - 2012
Multisource feedback (MSF) is often promoted as a useful approach for formative assessment and is increasingly becoming part of regulatory-based assessment programs, such as revalidation and maintenance of certification. However, to achieve the full potential of MSF, substantially more attention should be directed at the specific purpose of the MSF ...
Baker P N - - 2012
Current analysis of unicondylar knee replacements (UKRs) by national registries is based on the pooled results of medial and lateral implants. Consequently, little is known about the differential performance of medial and lateral replacements and the influence of each implant type within these pooled analyses. Using data from the National ...
Kimura Dai - - 2012
Our goal was to determine the factors associated with prolonged acidosis in children with diabetic ketoacidosis. The records of all children (109 admissions, 86 patients) admitted to the pediatric intensive care unit (PICU) during a 3-year period with the diagnosis of diabetic ketoacidosis were analyzed. The charts were reviewed after ...
Sakai Akinori - - 2012
Osteocytes sense mechanical stress. Many long cell processes of osteocytes connect with osteoblasts and osteoclasts as well as other osteocytes. Tethering elements on the cell processes amplify mechanical strain. Primary cilia of osteocytes and integrin of extracellular matrix act as mechnosensors. Osteocytes express RANKL. The disruption of osteocyte-specific RANKL leads ...
Burlew Clay Cothren - - 2012
In the past three decades, there has been a significant clinical shift in the performance of resuscitative thoracotomy (RT), from a nearly obligatory procedure before declaring any trauma patient deceased to a more selective application of RT. We have sought to formulate an evidence-based guideline for the current indications for ...
Clancy Gerard P - - 2012
Many urban areas struggle with significant health disparities. In Tulsa, Oklahoma, there is a 14-year difference in life expectancy between the predominantly African American population in north Tulsa and the predominantly Caucasian population in south Tulsa. The roots of Tulsa's health disparities can be linked, in part, to a long ...
Meena Sanjay - - 2012
Traumatic posterior hip dislocation is an uncommon injury in children, constituting less than 5% of paediatric dislocations. In a younger child (less than 5 years), minor trauma such as a slip or fall from a low height may cause a hip dislocation, whereas in an adolescent a dislocation is usually ...
Hoy Haley M - - 2012
Background-Although current national data show improved graft and patient survival following lung transplant, the effects of several modifiable preexisting comorbid conditions on health-related quality of life after transplant have not been evaluated. This study examines the effects of 3 comorbid conditions present before lung transplant (reduced bone density, diabetes mellitus, ...
Willi B - - 2012
Primary hyperaldosteronism is a clinical syndrome characterized by an elevated aldosterone secretion by the adrenals. The present case series describes 7 cats with primary hyperaldosteronism, which were presented between 2002 and 2011. Common clinical symptoms were weakness, anorexia, cervical ventroflexion and blindness. All cats showed hypokalemia. In 6 cats, blood ...
Gordon Christopher T - - 2012
: Oesophageal atresia (OA) and mandibulofacial dysostosis (MFD) are two congenital malformations for which the molecular bases of syndromic forms are being identified at a rapid rate. In particular, the EFTUD2 gene encoding a protein of the spliceosome complex has been found mutated in patients with MFD and microcephaly (MIM610536). ...
Todd S Rob - - 2012
Studies have documented a correlation between hypothyroxinemia and mortality in critically ill patients; however, there are limited data in sepsis. The objective of this study was to assess baseline thyroid function studies and their association with mortality in surgical sepsis. We hypothesized that the relatively decreased levels of free thyroxine ...
Zhang Jing - - 2012
Objective: To investigate the expression of Caspase-3 and Hsp70 in rabbits after severe traumatic brain injury (TBI) and to explore the feasibility of its application in estimation of injury time in forensic medicine. Methods: A rabbit model of heavy TBI was developed by high velocity impact on the parietal bone ...
Ohnishi Isao - - 2012
Fragility fractures are the most serious complication of osteoporosis and have been recognized as a major public health problem. It is essential to precisely quantify the stress or strength of the fragile bone in order to estimate the fracture risk and plan preventive interventions. Quantitative computed tomography-based finite element method ...
Sugerman David E - - 2012
Patients with severe traumatic brain injury (TBI), head Abbreviated Injury Scale (AIS) score of 3 or greater, who are indirectly transported from the scene of injury to a nontrauma center can experience delays to definitive neurosurgical management. Transport to a hospital with appropriate initial emergency department treatment and rapid admission ...
Madan Alok - - 2012
Context-Little systematic research has been conducted to understand pain among persons with end-stage liver disease, especially among liver transplant candidates. Appropriate pain assessment and management are important areas of consideration as treatment options are limited.Objective-To describe the nature of chronic pain in patients with end-stage liver disease, the extent to ...
Foster P A L - - 2012
We report on the use of the Ilizarov method to treat 40 consecutive fractures of the tibial shaft (35 AO 42C fractures and five AO 42B3 fractures) in adults. There were 28 men and 12 women with a mean age of 43 years (19 to 81). The series included 19 ...
Chao Wai-Nang - - 2012
The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score has been verified as a useful diagnostic tool for detecting necrotizing fasciitis (NF). Its application, however, is mainly for NF types I and II. The practical relevance of the LRINEC score for Vibro vulnificus-related skin and soft tissue infection (SSTI) was ...
Kalinowski S - - 2012
Pain and fear of falling (FOF) are modifiable factors that might play an important role in functional performance of nursing homes residents (NHR). Both factors are characterised by deficits in research and provision of long-term care services. The purpose of this study was to examine the functional performance of NHR ...
Dickson T - - 2012
Blood samples for the determination of plasma cortisol concentration are generally obtained via venipuncture or capillary sampling at the fingertip. During rock climbing the upper body, forearms and fingertips are subject to continual loading and gripping making sampling at these sites problematic. The purpose of this study was to examine ...
Yu Yong-Min - - 2012
Objective: To introduce a new animal model of graded mechanical primary brainstem injury (BSI). Methods: Altogether 45 rabbits were subjected to BSI by type II biological impact machine designed by the Third Military Medical University. The animals were divided into 4 experimental groups (n equal to 10) and 1 control ...
Mukai Chiaki - - 2012
Despite the fact that astronauts living in the International Space Station (ISS) conduct daily two-hour intensive exercise programs to maintain their health, many health problems persist. These problems which include adverse effects of microgravity to bone, muscle and stamina, have not completely been countered. For example, bone mass reduction (about ...
Van Haren Robert M - - 2012
Trauma center performance depends on quality metrics, such as mortality rates, but there have been few studies on how an exact definition of death can influence these statistics. The purpose of this study was to test the hypothesis that the mortality rate at one trauma center could be influenced by ...
Vlatten Arnim A Department of Pediatric Anesthesia, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada. - - 2012
Airway management in children with cervical spine may make direct laryngoscopy difficult. Video laryngoscopy is an alternative to direct laryngoscopy. The GlideScope video laryngoscope, successfully used in expected and unexpected difficult pediatric airway situations, has not been studied so far in children with cervical spine immobilization. A total of 23 ...
Kinoshita Yuka - - 2012
Immobilization or unloading results in rapid bone loss by both enhanced bone resorption and suppressed bone formation. Bisphosphonates have been used to treat immobilization osteoporosis to suppress increased bone resorption. Recently, parathyroid hormone and anti-sclerostin antibody have been shown to enhance bone formation in immobilized or unloaded animal models. It ...
Passalacqua Giovanni - - 2012
Allergic rhinitis (AR) is a high-prevalence disease, sustained by an IgE-triggered reaction with histamine release, followed by an inflammatory response which involves cells, mediators, cytokines and adhesion molecules. According to its duration, AR can be either intermittent or persistent. In the persistent form, the inflammatory component usually predominates. The current ...
Daurka J S - - 2012
The inherent challenges of total hip replacement (THR) in children include the choice of implant for the often atypical anatomical morphology, its fixation to an immature growing skeleton and the bearing surface employed to achieve a successful long-term result. We report the medium-term results of 52 consecutive uncemented THRs undertaken ...
Khanduja V - - 2012
The FRCS (Tr & Orth) examination has three components: MCQs, Vivas and Clinical Examination. The Vivas are further divided into four sections comprising Basic Science, Adult Pathology, Hands and Children's Orthopaedics and Trauma. The Clinical Examination section is divided into Upper and Lower limb cases. The aim of this section ...
Williams Laurel - - 2012
Context-Little has been published about the caregiving experiences of the parents or guardians of children receiving liver or liver/intestinal transplants.Objective-To describe the lived experiences of parents and guardians as they prepared for and provided postdischarge care to a child who received an isolated intestine or a liver/intestinal transplant and to ...
Bein Thomas - - 2012
Advances in oxygenator membrane, vascular cannula, and centrifugal pump technologies led to the miniaturization of extracorporeal lung support (ECLS) and simplified its insertion and use. Support of combat injuries complicated by severe respiratory failure requires critical care resources not sustainable in the deployed environment. In response to this need, a ...
Verma Vinit - - 2012
Simultaneous bilateral intertrochanteric fractures are very rare. There is a paucity of data in current literature documenting patients with such kind of hip fractures. It is severe and potentially life-threatening, associated with a high morbidity. The major determinants of successful outcome are high vigilance, early single stage stabilization and mobilization ...
Gisbert Javier P - - 2012
The aim of the Clinical Practice Guideline (CPG) on the Management of Patients with Dyspepsia is to generate recommendations on the optimal approach to dyspepsia in the primary care and specialized outpatient setting. The main objective of this CPG is to help to optimize the diagnostic process, identifying patients with ...
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