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Schoenenberger Joan A JA Pharmacy Service, Arnau de Vilanova University Hospital, Lleida, Spain. - - 2013
Therapeutic drug monitoring (TDM) of antiretroviral drugs (ARVs) is used to improve the efficacy and safety of ARVs, but there is little interest for the systematic or random TDM of ARVs in the medical management of patients with acquired immune deficiency syndrome. This study aimed to evaluate a different approach ...
Caplinskas Saulius S Centre for Communicable Diseases and AIDS and Faculty of Social Policy, University of Mykolas Romeris, Vilnius, - - 2013
To analyze HIV-1 genotypes in Lithuania and the transmission of drug-resistant viruses, HIV-1 sequences were obtained from 138 individuals, who were diagnosed as HIV-1 infected in 1990-2008 and represented all major risk groups. Subtype A strains, dominating in the former Soviet Union (90% of cases), were found in 60% of ...
Justice Amy C AC Department of Internal Medicine, Yale University and the Veterans Affairs Healthcare System, West Haven, CT 06516, USA. - - 2013
By supplementing an index composed of HIV biomarkers and age (restricted index) with measures of organ injury, the Veterans Aging Cohort Study (VACS) index more completely reflects risk of mortality. We compare the accuracy of the VACS and restricted indices (1) among subjects outside the Veterans Affairs Healthcare System, (2) ...
Sun Bing B Department of Laboratory Medicine, Veterans Affairs Medical Center, San Francisco, CA 94121, - - 2013
Individuals infected with both HIV and hepatitis C virus (HCV) have shown impaired performance on different neuropsychological (NP) tests; however, whether coinfected individuals with controlled HIV and minimal liver damage in the era of antiretroviral therapy have impairment is understudied. Nineteen HCV monoinfected, 17 HIV/HCV coinfected, and 17 control male ...
Vest Michael T MT Department of Internal Medicine, Section of Pulmonary and Critical Care Medicine, Yale School of Medicine, New Haven, CT 06520, - - 2013
Many older patients with early stage non-small cell lung cancer (NSCLC) do not receive curative therapy. New surgical techniques and radiation therapy modalities, such as video-assisted thoracoscopic surgery (VATS), potentially allow more patients to receive treatment. The adoption of these techniques and their impact on access to cancer care among ...
McGowan Emily C EC Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. - - 2013
The basophil activation test (BAT) is a flow-cytometry-based functional assay that assesses the degree of cell activation after exposure to a stimuli. Though no standardized technique currently exists, recent advances have improved the performance of this assay, including identification of new basophil-specific markers and comparisons of the expression of CD63 ...
Gray Bethany Powell BP Department of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8807, - - 2013
Phage display is commonly used to isolate peptides that bind to a desired cell type. While chemical synthesis of selected peptides often results in ligands with low affinity, a multivalent tetrameric presentation of the peptides dramatically improves affinity. One of the primary uses of these peptides is conjugation to nanoparticle-based ...
Coffin Phillip Oliver PO San Francisco Department of Public Health, San Francisco, California, USA; University of California, San Francisco, CA 94102, USA. - - 2013
To test aripiprazole for efficacy in decreasing use in methamphetamine-dependent adults, compared to placebo. Participants were randomized to receive 12 weeks of aripiprazole or placebo, with a 3-month follow-up and a platform of weekly 30-minute substance abuse counseling. The trial was conducted from January 2009 to March 2012 at the ...
Papaconstantinou Ioanna C - - 2013
On the basis of the results of in-silico predictions and in an effort to extend our structure-activity relationship studies, the aromatic nitrogen mustard 2-[4-N,N-bis(2-chloroethyl) amino-phenyl]butanoic acid (2-PHE-BU) was synthesized and conjugated with various steroidal alcohols. The resulting steroidal esters were evaluated for their in-vivo toxicity and antileukemic activity in P388-leukemia-bearing ...
Lee Judy W - - 2013
Traditional upper blepharoplasty typically involves resection of excess upper eyelid skin and muscle with or without fat excision. Well-established concepts in periorbital aging have been challenged by newer morphologic and histologic studies that have characterized the changes that occur in the various periorbital soft tissue components. Several modified or adjunctive ...
Fitzgerald Rebecca - - 2013
This article outlines current concepts in aging brows and lids, and focuses on the current "evolution" to the 3-dimensional construct. Relevant anatomy is reviewed in detail because thoughtful analysis of the underlying anatomy, ethnicity, gender, and goals of each patient will greatly enhance our ability to address site-specific corrections to ...
Li Jiuyi - - 2013
The use of flow displacement systems for studying initial bacterial adhesion to surfaces is mostly confined to transparent substrata. The objective of this study was to investigate a method based on macroscopic fluorescence imaging to enumerate adhering fluorescent bacteria on non-transparent substrata, real-time and under flow. To this end, a ...
Vucko M J - - 2013
Cold spray metal embedment is an innovative antifouling (AF) technology that delivers metal particles with AF properties into many thermoplastic polymers. AF efficacy was quantified for low (22.1 ± 4.8 g m(-2)) and high (101.1 ± 10.8 g m(-2)) densities of copper particles embedded into polyurethane (PU) seismic streamer skins, which are used in ...
Rose Amy E - - 2013
Loss of volume in the temples is an early sign of aging that is often overlooked by both the physician and the patient. Augmentation of the temple using soft tissue fillers improves the contours of the upper face with the secondary effect of lengthening and lifting the lateral brow. After ...
Lieberman David M - - 2013
Upper eyelid blepharoplasty is one of the most common facial plastic surgeries performed in the United States. Understanding how brow position contributes to the upper eyelid appearance is essential. Consistent and desirable surgical outcomes are best achieved with a detailed knowledge of periorbital anatomy. The surgeon must understand patients' expectations ...
Brauer Jeremy A - - 2013
The focus of this article is treatments of the brow and upper lid, in the context of appreciating their relationship to the forehead and periorbital complex to best evaluate and treat. This material is focused on treatments designed to stimulate collagen synthesis, as well as improve fine lines, wrinkles, and ...
Sundaram Hema - - 2013
The physician and surgeon will find here a detailed and comprehensive discussion of nonsurgical rejuvenation tools and techniques, along with thoughtful insights into evaluating and treating the aging upper face, such as the concept of visualizing a "periorbital frame" that is bordered by the eyebrows, glabella, temporal fossa, and superior ...
DeCarlo Dawn K - - 2013
To determine the relationship between refractive error as measured by autorefraction and that measured by trial frame refraction among a sample of adults with vision impairment seen in a university-based low-vision clinic and to determine if autorefraction might be a suitable replacement for trial frame refraction. A retrospective chart review ...
Lasarre Breah - - 2013
Recent studies have established the fact that multiple members of the Rgg family of transcriptional regulators serve as key components of quorum sensing (QS) pathways that utilize peptides as intercellular signaling molecules. We previously described a novel QS system in Streptococcus pyogenes which utilizes two Rgg-family regulators (Rgg2 and Rgg3) ...
Nanba Kazutaka - - 2013
Hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is an autosomal dominant disorder caused by a GATA3 gene mutation. Here we report a novel mutation of GATA3 in a patient diagnosed with HDR syndrome at the age of 58 with extensive intracranial calcification. A 58-year-old Japanese man showed severe hypocalcemia and ...
Li Haochuan - - 2013
Expression of the chemokine receptor CXCR4 by tumors is associated with metastatic migration and invasion of tumor cells. The importance of CXCR4 expression by uveal melanomas in metastasis to the liver was recently demonstrated when injection of CXCR4-negative uveal melanoma cells into mice resulted in reduced liver metastasis compared with ...
Mendoza Victoria V Endocrinology Service, Experimental Endocrinology Unit, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social 11560 Mexico City, - - 2013
To evaluate different elements of the calciotropic system in a group of house staff physicians, comparing them with age, gender, and body mass index (BMI) matched controls. We measured vitamin D, calcium, phosphorus, parathyroid hormone (PTH), glucose, insulin (estimating the insulin resistance index by the homeostatic model [HOMA]), and lipid ...
Nabavi Cameron B CB Department of Ophthalmology, The University of Alabama at Birmingham, Birmingham, AL 35209, USA. - - 2013
To describe a novel surgical treatment for patients with chronic relapsing conjunctivitis, corneal epitheliopathy, and ptosis secondary to giant fornix syndrome. A retrospective case series was performed looking at the presence or absence of preoperative symptoms of eye irritation, tearing, blurry vision, and discharge in 6 patients diagnosed with giant ...
Goldman Marina M Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. - - 2013
: Determining the brain substrates underlying the motivation to abuse addictive drugs is critical for understanding and treating addictive disorders. Laboratory neuroimaging studies have demonstrated differential activation of limbic and motivational circuitry (eg, amygdala, hippocampus, ventral striatum, insula, and orbitofrontal cortex) triggered by cocaine, heroin, nicotine, and alcohol cues. The ...
Kuburović Vladimir V Mother and Child Healthcare Institute of Serbia, School of Medicine, University of Belgrade, Belgrade, - - 2013
Alström syndrome is a rare disorder typified by early childhood obesity, neurosensory deficits, cardiomyopathy, progressive renal and hepatic dysfunction, and endocrinological features such as severe insulin resistance, type 2 diabetes, hyperlipidemia, and hypogonadism. Widespread fibrosis leads to multiple organ failure. Mutations in ALMS1 cause Alström syndrome. Two age-matched, unrelated adolescent ...
Du Xiaoping X Hough Ear Institute, Oklahoma City, - - 2013
Magnetically susceptible PLGA nanoparticles will effectively target the round window membrane (RWM) for delivery of dexamethasone-acetate (Dex-Ac) to the scala tympani. Targeted delivery of therapeutics to specific tissues can be accomplished using different targeting mechanisms. One technology includes iron oxide nanoparticles, susceptible to external magnetic fields. If a nanocomposite composed ...
Bao Yuhua Y Department of Public Health, Weill Cornell Medical College, New York, NY 10065, USA. - - 2013
Discussions of health care delivery and payment reforms have largely been silent about how behavioral health could be incorporated into reform initiatives. This paper draws attention to four patient populations defined by the severity of their behavioral health conditions and insurance status. It discusses the potentials and limitations of three ...
Strong E Bradley EB Department of Otolaryngology, University of California Davis, Sacramento, CA 95817, USA. - - 2013
: To demonstrate the accuracy and efficiency of a novel software tool designed specifically for volumetric analysis of the orbit. : The software was evaluated for accuracy and speed in analysis of orbital CT data sets. The analysis included: 1) intraoperator error: one operator repeatedly evaluated a single orbit multiple ...
Wan Ting T Eye Center, Affiliated Second Hospital, School of Medicine, Zhejiang University, Hangzhou, - - 2013
To determine the function of tumor necrosis factor receptor-2 (TNFR2) in retinal development and ischemia-induced revascularization in an oxygen-induced retinopathy (OIR) model. Mice with a global deletion of TNFR2 (TNFR2-KO) or with a vascular endothelial cell (EC)-specific TNFR2 transgene (TNFR2-TG) were compared to wild-type C57BL/6 mice (WT). Retinal vasculature development ...
Dal-Ré Rafael R Clinical Research Program, Pasqual Maragall Foundation, Barcelona, Spain. - - 2013
This study describes the main characteristics of ongoing observational studies on Alzheimer's disease (AD) to help identify any important research gaps. A search through the WHO International Clinical Trials Registry Platform and on the Primary Registries was conducted on 9 June 2012. The descriptors 'recruiting' or 'open' were used to ...
Dwyer Rebecca R Dementia Research Group, School of Clinical Sciences, University of Bristol, Frenchay Day Hospital, Bristol, - - 2013
Vascular cognitive impairment (VCI), including vascular dementia, is the second most common dementia after Alzheimer's disease. Despite its prevalence, the genetic etiology of sporadic VCI is largely unknown. We conducted a systematic review of all published genetic association studies of forms of sporadic VCI prior to 6 July 2012. An ...
Gabelle Audrey A Centre Mémoire Ressources Recherche Languedoc-Roussillon, CHU de Montpellier, hôpital Gui de Chauliac, Montpellier Cedex 5, France. - - 2013
The French Alzheimer's Disease Plan aims, in an unprecedented national effort, to develop research, promote optimal diagnosis, and take better care of patients. In order to evaluate the clinical interest and use of cerebrospinal fluid (CSF) biomarkers, a data-sharing project, the PLM (Paris-North, Lille and Montpellier) study has emerged through ...
Tang Maoping M School of Life Science and Biotechnology, Shanghai JiaoTong University, Shanghai, - - 2013
This study focused on a promising drug candidate, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-acrylamide (gx-50), a compound extracted from Sichuan pepper (Zanthoxylum Bungeanum), to determine whether it would be an effective therapeutic for Alzheimer's disease (AD) via biological experiments. In vivo, we determined the pharmacokinetic profile of gx-50 and evaluated the effect of gx-50 on ...
Froestl Wolfgang W AC Immune SA, EPFL, Lausanne, Switzerland. - - 2013
Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or aging. Cognition refers to a capacity for information processing, applying knowledge, and changing preferences. It involves memory, attention, executive functions, perception, language, and psychomotor functions. The term nootropics ...
Mizwicki Mathew T MT Department of Surgery, David Geffen School of Medicine at UCLA, University of California-Los Angeles, CA 90095, USA. - - 2013
As immune defects in amyloid-β (Aβ) phagocytosis and degradation underlie Aβ deposition and inflammation in Alzheimer's disease (AD) brain, better understanding of the relation between Aβ phagocytosis and inflammation could lead to promising preventive strategies. We tested two immune modulators in peripheral blood mononuclear cells (PBMCs) of AD patients and ...
Lewis Lionel D LD Sections of Clinical Pharmacology and Hematology/Oncology, Department of Medicine, The Geisel School of Medicine at Dartmouth, The Norris Cotton Cancer Center, Lebanon, NH 03756, USA. - - 2013
Docetaxel-related neutropenia was associated with polymorphisms in the drug transporters ABCC2 and SLCO1B3 in Japanese cancer patients. We hypothesized that this association is because of reduced docetaxel clearance, associated with polymorphisms in those genes. We studied 64 US cancer patients who received a single cycle of 75 mg/m of docetaxel ...
Manickam Buvana B Section of Endocrinology and Metabolism, Department of Medicine, Jesse Brown VA and Section of Endocrinology and Metabolism, Department of Medicine, University of Illinois Medical Centers, Chicago, IL 60612, - - 2013
To examine whether (1) serum 25-hydroxyvitamin D level (25[OH]D) is a risk factor for hyperglycemia, as assessed by glycated hemoglobin (HbA1c), in African American men (AAM) and (2) 25(OH)D is a predictor of HbA1c in AAM and Caucasian American men (CAM). We prospectively assessed 25(OH)D and HbA1c in 1,074 men, ...
Kam Kimberly R KR UC Berkeley & UCSF Graduate Program in Bioengineering, 1700 4th Street, Building QB3 Room 204, UCSF Mission Bay Campus, San Francisco, California 94158, - - 2013
Herein, we demonstrate that nanotopographical cues can be utilized to enable biologics >66 kDa to be transported across epithelial monolayers. When placed in contact with epithelial monolayers, nanostructured thin films loosen the epithelial barrier and allow for significantly increased transport of FITC-albumin, FITC-IgG, and a model therapeutic, etanercept. Our work ...
Eritsyan Ksenia U KU NGO of Social Projects in the Sphere of Population's Well-Being Stellit, Saint Petersburg, Russia. - - 2013
The HIV epidemic in Russia remains concentrated mostly among injection drug users (IDUs). Little is known about the extent to which sexual partnerships are the bridge between IDUs and the general population and create the potential for generalizing the epidemic. IDUs in two Russian cities, Novosibirsk and Ivanovo (N=593), were ...
Gallego-Escuredo José M - - 2012
BACKGROUND:: To determine the role of fibroblast growth factor (FGF)-19 and FGF21 and the endocrine FGFs receptor system in the metabolic alterations that manifest in HIV-1-infected patients undergoing highly active antiretroviral treatment (HAART). METHODS:: Serum FGF19 and FGF21 levels were determined in 4 groups of individuals as follows: (1) HIV-1-infected ...
Chen Jianmeng J Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, - - 2012
Phase 0 studies can provide initial pharmacokinetics (PKs) data in humans and help to facilitate early drug development, but their predictive value for standard dosing is controversial. To evaluate the prediction of microdosing for active intracellular drug metabolites, we compared the PK profile of 2 antiretroviral drugs, zidovudine (ZDV) and ...
Chen Junjun J Institute for Bioscience and Biotechnology Research, Rockville, Maryland 20850, United - - 2013
It is likely that expression and/or post-translational generation of various protein isoforms can be indicative of initial pathological changes or pathology development. However, selective quantification of individual protein isoforms remains a challenge, because they simultaneously possess common and unique amino acid sequences. Quantification concatamer (QconCAT) internal standards were originally designed ...
Chang Ting-Chou TC Department of Chemistry and Biochemistry, National Chung Cheng University, Min-Hsiung, Chia-Yi, - - 2013
In this paper, one simple and label-free biosensing method has been developed for determining the binding kinetic constants of antiovalbumin antibody (anti-OVA) and anti-mouse IgG antibody using the fiber optic particle plasmon resonance (FOPPR) biosensor. The FOPPR sensor is based on gold-nanoparticle-modified optical fiber, where the gold nanoparticle surface has ...
Slivka Peter F PF Department of Chemistry and Biochemistry and the Molecular Biophysics Program, University of Colorado, Boulder, CO 80309-0215, - - 2012
Bacteria utilize a large multiprotein chemosensory array to sense attractants and repellents in their environment. The array is a hexagonal lattice formed from three core proteins: a transmembrane receptor, the His kinase CheA, and the adaptor protein CheW. The resulting, highly networked array architecture yields several advantages including strong positive ...
Mellor Jonathan E JE Department of Civil and Environmental Engineering, The University of Virginia, VA, - - 2012
Researchers have long studied the causes and prevention strategies of poor household water quality and early childhood diarrhea using intervention-control trials. Although the results of such trails can lead to useful information, they do not capture the complexity of this natural/engineered/social system. We report on the development of an agent-based ...
Kumar Sandeep S Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, - - 2013
Amino acids are covalently attached to their corresponding transfer RNAs (tRNAs) by aminoacyl-tRNA synthetases. Proofreading mechanisms exist to ensure that high fidelity is maintained in this key step in protein synthesis. Prolyl-tRNA synthetase (ProRS) can misacylate cognate tRNA(Pro) with Ala and Cys. The cis-editing domain of ProRS (INS) hydrolyzes Ala-tRNA(Pro), ...
Truong Thu H TH Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, - - 2012
Epidermal growth factor receptor (EGFR) exemplifies the family of receptor tyrosine kinases that mediate numerous cellular processes, including growth, proliferation, and differentiation. Moreover, gene amplification and EGFR mutations have been identified in a number of human malignancies, making this receptor an important target for the development of anticancer drugs. In ...
Chowdhury Goutam G Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, - - 2012
Cytochrome P450 (P450) 2E1 is the major enzyme that oxidizes N-nitrosodimethylamine [N,N-dimethylnitrosamine (DMN)], a carcinogen and also a representative of some nitrosamines formed endogenously. Oxidation of DMN by rat or human P450 2E1 to HCHO showed a high apparent intrinsic kinetic deuterium isotope effect (KIE), ≥8. The KIE was not ...
Jain Anuj - - 2012
Solitary coronal shear fractures of femoral condyle, such as Hoffa's fracture, are usually associated with supracondylar or intercondylar fractures of the femur. These fractures are rare and seen in the context of high energy mechanism leading to multiple injuries; therefore a thorough workup of the patient is required to rule ...
Subramanian K - - 2012
We propose a sequential Meta-Cognitive learning algorithm for Neuro-Fuzzy Inference System (McFIS) to efficiently recognize human actions from video sequence. Optical flow information between two consecutive image planes can represent actions hierarchically from local pixel level to global object level, and hence are used to describe the human action in ...
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