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Results 701 - 750 of 2827
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Yilmaz Serkan - - 2012
In vitro genotoxic effects of antioxidant additives, such as citric acid (CA) and phosphoric acid (PA) and their combination, as well as antimicrobial additives, such as benzoic acid (BA) and calcium propionate (CP), on human lymphocytes were determined using alkaline single-cell gel electrophoresis. There was a significant increase in the ...
Ortiz Arisa E AE Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, - - 2012
Port-wine stains (PWSs) are capillary vascular malformations that are commonly resistant to treatment. Currently, the pulsed dye laser (PDL) is the treatment of choice. Multiple treatments are required and complete blanching after laser irradiation is rarely achieved. We review current therapeutic modalities for PWSs and recent developments for enhanced clearance. ...
Matsuoka Toshiki - - 2012
This paper describes a novel nanofluidic phenomenon where untethered DNA and chromatin are linearized by rapidly narrowing an elastomeric nanochannel filled with solutions of the biopolymers. This nanoscale squeezing procedure generates hydrodynamic flows while also confining the biopolymers into smaller and smaller volumes. The unique features of this technique enable ...
Matthew-Maich Nancy - - 2012
AIMS AND OBJECTIVES: The research question explored was what are the processes and strategies used by frontline leaders to support the uptake of the Breastfeeding Best Practice Guideline by nurses in maternity care practice settings? BACKGROUND: Best Practice Guidelines have been shown to enhance client care and outcomes. Leadership is ...
Barton Brian - - 2012
The functional organization of human auditory cortex has not yet been characterized beyond a rudimentary level of detail. Here, we use functional MRI to measure the microstructure of orthogonal tonotopic and periodotopic gradients forming complete auditory field maps (AFMs) in human core and belt auditory cortex. These AFMs show clear ...
Quaas Marianne - - 2012
The tumor suppressor p53 plays an important role in cell cycle arrest by downregulating transcription. Many genes repressed by p53 code for proteins with functions in G₂/M. A large portion of these genes is controlled by cell cycle-dependent elements (CDE) and cell cycle genes homology regions (CHR) in their promoters. ...
Smith Lucas R LR Department of Bioengineering, University of California, San Diego, La Jolla, CA, - - 2013
Skeletal muscle function depends on the efficient coordination among subcellular systems. These systems are composed of proteins encoded by a subset of genes, all of which are tightly regulated. In the cases where regulation is altered because of disease or injury, dysfunction occurs. To enable objective analysis of muscle gene ...
Tam-Tham Helen - - 2012
OBJECTIVES: The objective of our study is to evaluate the effectiveness of dementia case management compared with usual care on reducing long-term care placement, hospitalization, and emergency department visits for adult patients with dementia. We also sought to evaluate the effectiveness of this intervention on delaying time to long-term care ...
Gao Zhiqiang - - 2012
An electrochemical biosensor utilizing the electron-transfer impeding (insulating) power of a conducting polymer for label-free genotyping single-nucleotide polymorphisms is proposed. Excellent selectivity and sensitivity are accomplished through the engagement of a nuclease clean-up step and a cumulative signal generation/amplification process, respectively.
Wang Lin L Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, University of Münster, Münster, - - 2013
In mammals, postnatal haematopoiesis occurs in the bone marrow (BM) and involves specialized microenvironments controlling haematopoietic stem cell (HSC) behaviour and, in particular, stem cell dormancy and self-renewal. While these processes have been linked to a number of different stromal cell types and signalling pathways, it is currently unclear whether ...
Jiang Yue - - 2012
Genetic variants may influence miRNA-mRNA interaction through modulate binding affinity, creating or destroying miRNA binding sites. Twenty-four single nucleotide polymorphisms (SNPs) that were predicted to affect the binding affinity of breast cancer related miRNAs to 3'-UTR of known genes were genotyped in 878 breast cancer cases and 900 controls in ...
Radousky H B - - 2012
Energy harvesting refers to the set of processes by which useful energy is captured from waste, environmental, or mechanical sources and is converted into a usable form. The discipline of energy harvesting is a broad topic that includes established methods and materials such as photovoltaics and thermoelectrics, as well as ...
Ten Brink Dirk-Jan DJ Biodiversity Group, Department of Biology, Lund University, Lund, Sweden. - - 2013
This study examined the adaptive association between seed germination ecology and specialization to either forest or open habitats across a range of evolutionary lineages of seed plants, in order to test the hypotheses that (1) species' specialization to open vs. shaded habitats is consistently accompanied by specialization in their regeneration ...
Christou E - - 2012
We present a case of non-involuting congenital haemangioma (NICH) of the right eyelid which was present at birth as a purpuric macule but increased in size to cause significant obstruction of vision. At four years of age the lesion was treated with fluroscopic ultrasound-guided sclerotherapy using 0.5% sodium tetradecyl suphate ...
Cavanna Andrea E - - 2012
Tourette syndrome (TS) is a neurological condition first described by Georges Gilles de la Tourette in 1885. TS was largely thought of as a rare and bizarre condition until the 1960s, when the beneficial effects of neuroleptics on tic symptoms led to an exponential increase in neuroscientific research. Today TS ...
Liu Yuyang - - 2012
This paper reports on the fabrication of cotton fabrics with single-faced superhydrophobicity using a simple foam finishing process. Unlike most commonly reported superhydrophobic fabrics, the fabrics developed in this study exhibit asymmetric wettability on their two faces: one face showing superhydrophobic behaviors (highly non-wetting or water-repellent characteristics) and the other ...
Chen Shih-Pin - - 2012
In this study, a simple and effective silver ink formulation was developed to generate silver tracks with high electrical conductivity on flexible substrates at low sintering temperatures. Diethanolamine (DEA), a self-oxidizing compound at moderate temperatures, was mixed with silver ammonia solution to form a clear and stable solution. After inkjet-printed ...
Wang Hao - - 2012
An overview of the municipal solid waste (MSW) management in Beijing, a city with a resident population of about 19.61 million in 2010, is presented in the article. Economic development and population growth have resulted in a MSW generation increase from 2.96 million tons in 2000 to 6.20 million tons ...
Bonvin Florence - - 2012
The presence of potentially persistent and bioactive human metabolites in surface waters gives rise to concern; yet little is known to date about the environmental fate of these compounds. This work investigates the direct photolysis of human metabolites of the antibiotic sulfamethoxazole (SMX). In particular, we determined photolysis kinetics and ...
Ciardelli Francesco - - 2012
The detection of mechanical stress in polymeric materials through optical variations has attracted considerable interest over the past ten years. In this tutorial review, the current state of knowledge concerning the preparation of polymers with mechanochromic features is summarized. Two types of procedures are illustrated and thoroughly discussed along with ...
Omran Nahla Ee - - 2012
Holothuria polii (Delle Chiaje, 1823) (Holothuriidae) is a sea cucumber inhabiting Mediterranean Sea coast of Egypt. The bioactive compound of its tegument has antifungal, antibacterial and antiparasitic effects. The present study aims to elucidate the structure of the bioactive material of H. polii for pharmacological and chemotaxonomic purposes. Furthermore, the ...
Helbok Raimund - - 2012
ABSTRACT: INTRODUCTION: Daily interruption of sedation (IS) has been implemented in 30- 40% of intensive care units worldwide and may improve outcome in medical intensive care patients. Little is known about the benefit of IS in acutely brain-injured patients. METHODS: This prospective observational study was performed in a neuroscience intensive ...
Whitbeck Matthew G MG Division of Cardiovascular Medicine, Gill Heart Institute University of Kentucky, 900 South Limestone Street, Lexington, KY 40536-0200, - - 2013
Digoxin is frequently used for rate control of atrial fibrillation (AF). It has, however, been associated with increased mortality. It remains unclear whether digoxin itself is responsible for the increased mortality (toxic drug effect) or whether it is prescribed to sicker patients with inherently higher mortality due to comorbidities. The ...
Fowler Mike A - - 2012
The Model Free (MF) analysis was applied to the fluorescence decays of 33 pyrene-labelled macromolecules to probe their internal dynamics. Depending on whether a pyrene derivative was attached to the chain ends of a linear chain, randomly along a polymer backbone, or at the chain terminals of dendrimers, the MF ...
Tezer F Irsel FI Department of Neurology, Hacettepe University, Ankara, Turkey. - - 2013
We present the electroclinical features and cytogenetic findings of 2 siblings with the ring 20 chromosome (r(20)) phenotype, one of which had r(20) mosaicism. A history of epilepsy or learning problems should be determined in family members, although these relatives had no ring formation in chromosome 20. Whether the clinical ...
Guimarães Evelyn de F - - 2012
The objective of this study was to present a reliable and practical example of method validation and uncertainty assessment with an analytical method for the determination of polycyclic aromatic hydrocarbons (PAHs) in urban dust. The method was gas chromatography-mass spectrometry in combination with isotope dilution principle to achieve better accuracy ...
Jacombs A S W - - 2012
BACKGROUND: This study aimed to explore and quantify the selection process to guide the decision on closure type (myocutaneous flap repair (MFR) or primary closure) for people undergoing pelvic exenteration. METHODS: This was a retrospective analysis of a prospectively maintained database with review of hospital records for verification and capture ...
Chen Bo B Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. - - 2012
Subunit 6 of the COP9 signalosome complex, CSN6, is known to be critical to the regulation of the MDM2-p53 axis for cell proliferation and anti-apoptosis, but its many targets remain unclear. Here we show that p57 (Kip2) is a target of CSN6, and that CSN6 is a negative regulator of ...
Tojo Sachiko - - 2012
A central carbon-carbon (C-C) σ bond dissociation of polyphenylethane radical anions (Ph(n)E(•-), n= 3-6), mesolysis, was investigated by the transient absorption measurement during pulse radiolysis of Ph(n)E in 2-methyltetrahydrofuran. The charge resonance (CR) band of 1,1,2,2-tetraphenylethane radical anion (1,1,2,2-Ph(4)E(•-)) was observed in the near-infrared region immediately after an electron pulse ...
Selnes Per - - 2012
Neuropathological correlates of Alzheimer's disease (AD) emerge years before dementia. Biomarkers preceding cognitive decline and reflecting the causative processes can potentially aid early intervention and diagnosis. Diffusion tensor imaging (DTI) indirectly reflects tissue microstructure. To answer whether DTI is an early biomarker for AD and to explore the relationship between ...
King Allen B - - 2012
Objective: Compare the safety and efficacy of liraglutide to that of sitagliptin or exenatide as add-on to metformin in patients with type 2 diabetes and A1C <8.0%.Methods: Post-hoc analysis of 26-week data from LEAD-6 (liraglutide 1.8 mg once-daily (OD) vs. exenatide 10 μg twice daily) and LIRA-DPP-4 (liraglutide 1.8 mg ...
De Villers Mary Jo - - 2012
Nurses facing impediments to what they perceive as moral practice may experience moral distress. The purpose of this descriptive, cross-sectional study was to determine similarities and differences in moral distress and avoidance behavior between critical care nurses and non-critical care nurses. Sixty-eight critical care and 28 non-critical care nurses completed ...
Perez-Garcia Lluisa - - 2012
Cell tracking is an emergent area in nanobiotechnology, promising the study of individual cells or the identification of populations of cultured cells. In our approach to it, microtools designed for extracellular tagging are prepared, because using biofunctionalized polysilicon barcodes to tag cell membranes externally avoids the inconveniences of cell internalization. ...
Nitschke Joachim - - 2012
The phenomenon of sexual sadism was first scientifically described by Richard von Krafft-Ebing in 1999 as a sexual preference disorder that focuses on the infliction of suffering, pain, or humiliation to achieve sexual gratification. The present article reviews the historical development of the term sexual sadism, including the current descriptive ...
Deyhimi Parviz - - 2012
BACKGROUND: Pemphigus vulgaris (PV) is an autoimmune mucocutaneous disease presenting clinically with blisters or erosions of the skin and mucous membrane. The main histopathologic characteristic of this disease is suprabasal vesicles due to loss of cell-cell adhesion between keratinocytes named acantholysis. Studies have shown that apoptosis is increased in PV. ...
Rauta Satu - - 2012
Aims and objectives.  To define the core elements of perioperative nursing. Background.  To measure the nursing care intensity in operating departments and day surgery units, a consensus on the content of perioperative nursing is required. The core elements of perioperative nursing were initially defined based on literature and the clinical ...
Chaurasia Priyasri P Department of Biochemistry and Molecular Biology, Southern Illinois University, School of Medicine, Carbondale, Illinois 62901, - - 2013
Rad14p is a DNA damage recognition factor in nucleotide excision repair. Intriguingly, we show here that Rad14p associates with the promoter of a galactose-inducible GAL1 gene after transcriptional induction in the absence of DNA lesion. Such an association of Rad14p facilitates the recruitment of TBP, TFIIH, and RNA polymerase II ...
BasuRay Soumik S Department of Pathology and Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, - - 2013
Rab7 belongs to the Ras superfamily of small GTPases and is a master regulator of early to late endocytic membrane transport. Four missense mutations in the late endosomal Rab7 GTPase (L129F, K157N, N161T, and V162M) cause the autosomal dominant peripheral neuropathy Charcot-Marie-Tooth type 2B (CMT2B) disease. As yet, the pathological ...
Chen Dong - - 2012
Abstract Conclusion: Focal adhesion kinase (FAK) and integrin-linked kinase (ILK) are highly expressed in salivary adenoid cystic carcinoma (SACC), especially metastatic SACC, suggesting their potential role as prognostic markers for SACC. Objectives: This study aimed to investigate the expression of FAK, ILK, and phosphatase and tensin homolog deleted on chromosome ...
Oh Young-Min - - 2012
Carpal tunnel syndrome (CTS) is the most common peripheral nerve entrapment, causing pain, impairment, and disability. To identify comprehensively proteins of CTS, we performed a comparative serum analysis of CTS patients and normal control subjects. The two-dimensional electrophoresis patterns of serum from 6 CTS patients and 6 normal control subjects ...
Burrows Anthony M - - 2012
Pediatric patients with aneurysm often have different localizations and morphologies from adults and recurrences are not uncommon after successful clip reconstruction/obliteration. Treatment of a recurrent pediatric aneurysm after clip ligation is a technical challenge. We present the case of an adolescent with a middle cerebral artery (MCA) fusiform aneurysm which ...
Akhtar M S - - 2012
Two experiments were conducted to elucidate the possible effects of dietary L-tryptophan (TRP) in Labeo rohita based on growth performance and physio-biochemical responses. In the experiment I, a 60-day feeding trial was carried out to elucidate the effects of dietary TRP enrichment on growth performance and physio-biochemical responses. In the ...
Kreuwel I A M IA Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands. - - 2013
What is the relationship between the rate of elective single-embryo transfer (eSET) and couples' exposure to different elements of a multifaceted implementation strategy? Additional elements in a multifaceted implementation strategy do not result in an increased eSET rate. A multifaceted eSET implementation strategy with four different elements is effective in ...
Tekiel Antoni - - 2012
Ultra-thin NaCl films epitaxially grown on an Fe(001)-p(1 × 1)O surface have been investigated in ultra-high vacuum by non-contact atomic force microscopy and low energy electron diffraction. It has been found that at temperatures below 145 °C NaCl initially grows as monoatomic thick islands on substrate terraces, while at temperatures above 175 °C biatomic thick islands are ...
Shimato Shinji - - 2012
ABSTRACT: BACKGROUND: Vaccination against tumor-associated antigens is one promising approach to immunotherapy against malignant gliomas. While previous vaccine efforts have focused exclusively on HLA class I-restricted peptides, class II-restricted peptides are necessary to induce CD4+ helper T cells and sustain effective anti-tumor immunity. In this report we investigated the ability ...
Brodsky Stanley L - - 2012
This paper reexamines the Shuman seminal paper arguing against empathic behaviors in forensic evaluations. Shuman concluded that empathy by examiners seduces evaluees into believing a therapeutic relationship exists. We reconsider empathy as an element of rapport and a helpful supplement in a successful assessment. Actively avoiding empathy could lead to ...
Maeda Etsuo - - 2012
An easy and large-scale fabrication technique of metal fins was used to produce periodic Au fin arrays that realized light confinement in the near-infrared region. Light confinement was revealed by vortex patterns in the optical power flow of an array of high-aspect-ratio fins (height of 1000 nm for a width of ...
Loget Gabriel - - 2012
Based on the principles of bipolar electrochemistry, localized pH gradients are generated at the surface of conducting particles in solution. This allows the toposelective deposition of inorganic and organic polymer layers via a pH triggered precipitation mechanism. Due to the intrinsic symmetry breaking of the process, the concept can be ...
Knaus J - - 2012
Background: "Cloud" computing providers, such as the Amazon Web Services (AWS), offer stable and scalable computational resources based on hardware virtualization, with short, usually hourly, billing periods. The idea of pay-as-you-use seems appealing for biometry research units which have only lim-ited access to university or corporate data center resources or ...
Strzelczyk Joanna Katarzyna - - 2012
Oxidative stress is one of several factors which contribute to the development of colorectal carcinogenesis. The aim of the study was an assessment of the activity of antioxidant enzymes in tumour and corresponding normal distal mucosa in a group of patients with colorectal adenocarcinoma. Samples of tumour and corresponding normal ...
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