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Horwich Peter - - 2012
BACKGROUND AND AIM: We sought to evaluate the long-term impact of post-cardiac surgery atrial fibrillation on the risk of stroke and survival. METHODS: Patients undergoing isolated CABG surgery from April 1, 1995 to March 31, 2007 were identified (n = 8058). Long-term stroke data were compiled using Cox modeling adjusted for clinical ...
Langan Russell C - - 2012
INTRODUCTION: Autosomal dominant hyperimmunoglobulinemia E syndrome (HIES), also called Job's syndrome, is a primary immunodeficiency characterized by the triad of elevated immunoglobulin E levels, eczema, and infections. Its clinical course manifests as recurrent skin and pulmonary infections, and variable skeletal, connective tissue, and vascular abnormalities. There is evidence of abnormal ...
Zhu Hong - - 2012
Simple, fast, and sensitive HPLC coupled with an electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) method for the simultaneous determination of cnidilin and its two metabolites, 3″,8-methoxy-isoimperatorin (M1) and 5″-hydroxyl-8-methoxy-isoimperatorin (M2), in rat plasma has been developed. Pimpinellin was used as the internal standard and the total analysis time was 7 min. ...
Brandsma Henk-Thijs - - 2012
ABSTRACT: BACKGROUND: Parastomal hernia is a common complication of a colostomy. Ultimately, one-third of patients with a parastomal hernia will need surgical correction due to frequent leakage or life-threatening bowel obstruction or strangulation. However, treatment remains a challenge resulting in high recurrence rates. Two single center trials demonstrated that the ...
Halboos A - - 2012
History and clinical findings: A 69-year-old man came to the emergency unit because of vertigo and presyncope. A bipolar disorder - known since an age of 15 years - has been treated with 2 × 450 mg lithium and 100 mg perazine per day for several years (no other medications). With the ...
Rémond Marc Gerard - - 2012
ABSTRACT: BACKGROUND: In Australia, rheumatic heart disease (RHD) is almost exclusively restricted to Aboriginal Australian and Torres Strait Islander people with children being at highest risk. International criteria for echocardiographic diagnosis of RHD have been developed but the significance of minor abnormalities which do not reach these criteria remains unclear. ...
Klusek Jessica - - 2012
While there is a strong sex bias in the presentation of autism, it is unknown whether this bias is also present in subclinical manifestations of autism among relatives, or the broad autism phenotype. This study examined this question and investigated patterns of co-occurrence of broad autism phenotype traits within families ...
Dermitzakis Konstantinos - - 2012
Abstract Physiological studies of the human finger indicate that friction in the tendon-pulley system accounts for a considerable fraction of the total output force (9-12%) in a high-load static posteccentric configuration. Such a phenomenon can be exploited for robotic and prosthetic applications, as it can result in (1) an increase ...
Silva-Herdade A S - - 2012
Acetylcholinesterase (AChE) is found both on the membranes of neuronal and non-neuronal cells. In this study we performed intravenous administrations of velnacrine (VLN) and acetylcholine (ACh), respectively, AChE inhibitor and substrate, in an animal model of lipopolysaccharide (LPS)-induced inflammation in Wistar rats. Using intravital microscopy the number of rolling and ...
De Wilde Kirsten - - 2012
Among the many plant-based production systems that are being tested for molecular farming, seeds are very attractive as they provide a stable environment in which the accumulating recombinant proteins can be stored. However, it is not known exactly how high production levels of recombinant antibodies influence the endogenous transcriptome and ...
Beetsma Daniel J V - - 2012
Tics in Tourette Syndrome (TS) are often preceded by 'premonitory urges': annoying feelings or bodily sensations. We hypothesized that, by reducing annoyance of premonitory urges, tic behaviour may be reinforced. In a 2X2 experimental design in healthy participants, we studied the effects of premonitory urges (operationalized as air puffs on ...
Siggelkow Wulf - - 2012
ABSTRACT: BACKGROUND: Inhibitors targeting the cell cycle-regulated aurora kinase A (AURKA) are currently being developed. Here, we examine the prognostic impact of AURKA in node-negative breast cancer patients without adjuvant systemic therapy (n = 766). METHODS: AURKA was analyzed using microarray-based gene-expression data from three independent cohorts of node-negative breast ...
Levetan Claresa S - - 2012
Objective: To elucidate for clinical endocrinologists why diabetes is so difficult to treat despite the present tools and pharmacological armamentarium and to provide insights into emerging therapies including human and rodent data demonstrating the ability to transform progenitor cells that reside within the adult pancreas into new islets.Methods: Review of ...
Gruber Andreas R - - 2012
In eukaryotes, the 3' ends of RNA polymerase II-transcribed RNAs are generated in the majority of cases by site-specific endonucleolytic cleavage, followed by the addition of a poly(A) tail. Through alternative polyadenylation, a gene can give rise to multiple mRNA isoforms that differ in the length of their 3' UTRs ...
Yan Jixian - - 2012
A simple, low-cost, and sensitive 3D microfluidic origami electrochemiluminescence aptamer-device was developed based on a novel gold nanoparticle modified porous paper working electrode for point-of-care diagnosis.
Harris George F GF - - 2012
Vascular anomalies fall into two groups: vascular neoplasms and vascular malformations. Their behaviors differ, therefore they require different methods of management. Vascular lesions of the airway involve some degree of airway obstruction, although this may not be their primary manifestation. Areas of narrowing along this pathway have functional consequences for ...
Małodobra-Mazur Małgorzata - - 2012
Vitamin D3 (1,25(OH)2D3 (1,25-dihydroxyvitamin D3)) is a hormone playing a crucial role in numerous biological processes in the human body, including induction and control of cell proliferation and differentiation. Numerous data relate the vitamin D3 level with various types of cancer. It has been suggested that SNPs in the vitamin ...
Umedachi Takuya - - 2012
Abstract Behavioral diversity is an essential feature of living systems, enabling them to exhibit adaptive behavior in hostile and dynamically changing environments. However, traditional engineering approaches strive to avoid, or suppress, the behavioral diversity in artificial systems to achieve high performance in specific environments for given tasks. The goals of ...
Hassan Natalia - - 2012
Magneto-plasmonic microcapsules were prepared by the assembly of gold and γ-Fe(2)O(3) magnetic nanoparticles at the oil-water interface of microdroplets generated in a microfluidic device.
Foster Joshua D - - 2012
BACKGROUND AND PURPOSE: Activation of GABA(B) receptors in the dentate gyrus (DG) enhances granule cell (GC) activity by reducing synaptic inhibition imposed by hilar interneurons. This disinhibitory action facilitates signal transfer from the perforant path to the hippocampus. However, as the two main molecular subtypes, GABA(B(1a,2)) and GABA(B(1b,2)) receptors, prefer ...
Jayakumar Jaikishan - - 2012
In this paper, we review the path taken by signals originating from the short wavelength sensitive cones (S-cones) in Old World and New World primates. Two types of retinal ganglion cells (RGCs) carrying S-cone signals (blue-On and blue-Off cells) project to the dorsal lateral geniculate nucleus (dLGN) in the thalamus. ...
Streeten Elizabeth A - - 2012
Objective: Distinguishing sHPT from eucalcemic primary hyperparathyroidism (EC-pHPT) is important. The objective of this study was to measure PTH-stimulated production of 1,25(OH)2D in early postmenopausal patients with idiopathic sHPT, who also fit the criteria for EC-pHPT, compared to age-matched controls.Methods: In this pilot case-control study, postmenopausal women aged 44-55 with ...
Xiao You-Cai - - 2012
An asymmetric Diels-Alder reaction of 2-methyl-3-indolylmethanols and α,β-unsaturated aldehydes has been developed that relies on in situ generation of active indole-2,3-quinodimethane intermediates under mild acidic conditions and uses a secondary chiral amine as iminium activation catalyst. An array of highly enantioenriched tetrahydrocarbazoles have been efficiently produced in fair to good ...
Liang Zhipin - - 2012
The cellular protein tetherin tethers the HIV-1 viral particles on the cellular membrane to inhibit the replication of HIV-1. However, the HIV-1 accessory protein Vpu counteracts the antiviral function of tetherin. In this study, two retroviral vector plasmids were constructed. One inhibited the vpu gene expression; the other one over-expressed ...
Lampati L - - 2012
Sulprostone, a synthetic prostaglandin analogue with potent uterotonic action, has been shown to have a low complication rate in a large series. We present a case of cardiac arrest in a parturient after Caesarean section during continuous infusion of intravenous sulprostone administered for atonic post-partum haemorrhage. She had cardiopulmonary resuscitation ...
Bonnet Françoise - - 2012
ABSTRACT: BACKGROUND: Despite entering complete remission after primary treatment, a substantial proportion of patients with early stage breast cancer will develop metastases. Prediction of such an outcome remains challenging despite the clinical use of several prognostic parameters. Several reports indicate that genomic instability, as reflected in specific chromosomal aneuploidies and ...
Branthwaite Helen - - 2012
Modern footwear has been associated with the development of foot pain and pathology in the ageing adult. Yet this foot health issue does not seem to alter the footwear purchases made by younger women. In total, 162 teenage girls were questioned regarding shoes purchased over a 6-month period. The results ...
Mesters Ilse - - 2012
Abstract Infants of parents with a history of asthma could benefit from exclusive breastfeeding during the first 6 months of life to reduce the chance of developing childhood asthma. Continuing to breastfeed for 6 months seemed difficult to perform for many Dutch women. Therefore, an educational breastfeeding program was developed ...
Jung M - - 2012
Objectives: To analyze the attitude of physicians towards alertin g in CPOE systems in different hospitals in different countries, addressing various organizational and technical settings and the view of physicians not currently using a CPOE.Methods: A cross-sectional quantitative and qualitative questionnaire survey. We invited 2,600 physicians in eleven hospitals from ...
Buck Patrick M - - 2012
Aggregation is a common hurdle faced during the development of antibody therapeutics. In this study, we explore the potential aggregation liabilities of the Fab (fragment antigen-binding) from a human IgG1κ antibody via multiple elevated temperature molecular dynamic simulations, analogous to accelerated stability studies performed during formulation development. Deformation and solvent ...
Wu Di - - 2012
The construction of coronenes using simple building blocks is a challenging task. In this work, triphenylene was used as a building block to construct functionalized coronenes. Their solid structures and optoelectronic properties were investigated. The single crystal structures showed that coronenes had different packing motifs. Their good solubility and photostability ...
Hamama-Raz Yaira - - 2012
In this study we examined the meaning of being the wife of a vegetative patient over time. The research was based on semistructured interviews with 12 wives of husbands who were diagnosed with persistent vegetative state between 1 year 2 months and 10 years prior to the interview. We found ...
Elamin Ishraga - - 2012
The association between immunity and neurodevelopmental disorders has been extensively investigated in autism, suggesting a potential involvement of both cellular and humoral immunity in the establishment of synaptic connectivity modulation during development. A similar link has been proposed also for Tourette syndrome (TS), a complex, multifactorial disorder, in which the ...
Park Min Bum - - 2012
A solid understanding of the molecular-level mechanisms responsible for zeolite crystallization remains one of the most challenging issues in modern zeolite science. Here, we investigate the formation pathway for high-silica LTA zeolite crystals in the simultaneous presence of tetraethylammonium (TEA+), tetramethylammonium (TMA+), and Na+ ions as structure-directing agents (SDAs) with ...
Maryniak Agnieszka - - 2012
Objectives: To assess the cognitive, social, and emotional function in girls prenatally treated with dexamethasone (Dex) due to congenital adrenal hyperplasia (CAH), compared to CAH female patients not treated prenatally. Patients and methods: 33 girls from CAH families were studied: 17 girls treated prenatally with Dex (9 CAH-affected and 8 ...
Wøien Hilde - - 2012
AIMS AND OBJECTIVES: To assess the effects of introducing a systematic approach to pain and sedation management in the ICU. BACKGROUND: Identification of ICU patients' analgesic and sedative needs decreases the risk of complications and the hospital length of stay. Several studies have reported a lack of systematic assessment. DESIGN ...
Lugaresi Marialuisa - - 2012
OBJECTIVES: The misdiagnosis of short oesophagus may occur on recurrence of the hernia after surgery for type II-IV hiatal hernia (HH). The frequency of short oesophagus in type II-IV hernia is undefined. The aim of this study was to assess the frequency of true short oesophagus in patients undergoing surgery ...
Cirillo Teresa - - 2012
Ready-to-eat meals packed in polyethylene terephthalate (PET) and aluminium dishes, supplied to patients in two hospitals in the Campania region (Italy), were studied to evaluate the probable migration of di-n-butylphthalate (DBP) and di(2-ethylhexyl)phthalate (DEHP) from the packaging into the food. The influence of temperature, storage time and type of package ...
Trapp Marcus - - 2012
Enzymes are animated by a hierarchy of motions occurring on time scales that span more than 15 orders of magnitude from femtoseconds (10(-15)s) to several minutes. As a consequence, an enzyme is characterized by a large number of conformations, so-called conformational substates that interconvert via molecular motions. The energy landscape ...
Kim Ji Man - - 2012
This study investigates the relationship between economic status and mortality of Korean men and women who were under and over the average national life expectancy using Cox's proportional hazard model to adjust for health status, past medical history, and age. The study subjects come from local applicants of Korean National ...
Allbaugh Rachel A - - 2012
OBJECTIVE: To present a novel, minimally invasive technique for everted third eyelid cartilage correction in dogs that employs the use of low-energy cautery to remodel the cartilage. PROCEDURES: Twelve eyes of ten dogs had cautery performed under general anesthesia to correct everted third eyelid cartilage. The tip of a handheld ...
Rauthmann John F - - 2012
The MACH-IV was investigated (N = 528) with item response theory to elucidate its psychometric properties and suggest a trimmed version, the MACH*. The core content of the MACH-IV seemed to be cynicism/misanthropy and the MACH* was formed from the 5 most informative and precise MACH-IV items. The MACH* showed ...
Ee Su-Fang - - 2012
The importance of plant secondary metabolites for both mankind and the plant itself has long been established. However, despite extensive research on plant secondary metabolites, plant secondary metabolism and its regulation still remained poorly characterized. In this present study, cDNA-amplified fragment length polymorphism (cDNA-AFLP) transcript profiling was applied to generate ...
Liu Yi-Tao - - 2012
The solubility of boron nitride nanosheets (BNNSs) in different organic solvents is smartly tuned by using a "Janus" modifier, P(S-b-MMA), which enriches our choice of organic solvents for BNNSs, including low-boiling-point acetone, alkanes, cycloalkanes and benzene series, that are viewed as nonsolvents of BNNSs.
Fowler Mike A - - 2012
The Model Free (MF) analysis was applied to the fluorescence decays of 33 pyrene-labelled macromolecules to probe their internal dynamics. Depending on whether a pyrene derivative was attached to the chain ends of a linear chain, randomly along a polymer backbone, or at the chain terminals of dendrimers, the MF ...
Guimarães Evelyn de F - - 2012
The objective of this study was to present a reliable and practical example of method validation and uncertainty assessment with an analytical method for the determination of polycyclic aromatic hydrocarbons (PAHs) in urban dust. The method was gas chromatography-mass spectrometry in combination with isotope dilution principle to achieve better accuracy ...
Jacombs A S W - - 2012
BACKGROUND: This study aimed to explore and quantify the selection process to guide the decision on closure type (myocutaneous flap repair (MFR) or primary closure) for people undergoing pelvic exenteration. METHODS: This was a retrospective analysis of a prospectively maintained database with review of hospital records for verification and capture ...
Tojo Sachiko - - 2012
A central carbon-carbon (C-C) σ bond dissociation of polyphenylethane radical anions (Ph(n)E(•-), n= 3-6), mesolysis, was investigated by the transient absorption measurement during pulse radiolysis of Ph(n)E in 2-methyltetrahydrofuran. The charge resonance (CR) band of 1,1,2,2-tetraphenylethane radical anion (1,1,2,2-Ph(4)E(•-)) was observed in the near-infrared region immediately after an electron pulse ...
Selnes Per - - 2012
Neuropathological correlates of Alzheimer's disease (AD) emerge years before dementia. Biomarkers preceding cognitive decline and reflecting the causative processes can potentially aid early intervention and diagnosis. Diffusion tensor imaging (DTI) indirectly reflects tissue microstructure. To answer whether DTI is an early biomarker for AD and to explore the relationship between ...
King Allen B - - 2012
Objective: Compare the safety and efficacy of liraglutide to that of sitagliptin or exenatide as add-on to metformin in patients with type 2 diabetes and A1C <8.0%.Methods: Post-hoc analysis of 26-week data from LEAD-6 (liraglutide 1.8 mg once-daily (OD) vs. exenatide 10 μg twice daily) and LIRA-DPP-4 (liraglutide 1.8 mg ...
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