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Goessweiner-Mohr Nikolaus - - 2013
Conjugative plasmid transfer is the most important means of spreading antibiotic resistance and virulence genes among bacteria and therefore presents a serious threat to human health. The process requires direct cell-cell contact made possible by a multiprotein complex that spans cellular membranes and serves as a channel for macromolecular secretion. ...
Zheng Huiyuan - - 2012
Owing to its essential role in cancer, insulin-like growth factor type 1 receptor (IGF-1R)-targeted therapy is an exciting approach for cancer treatment. However, when translated into clinical trials, IGF-1R-specific antibodies did not fulfill expectations. Despite promising clinical responses in Ewing's sarcoma (ES) phase I/II trials, phase III trials were discouraging, ...
Moinard Christophe - - 2012
Adequate nutritional support is a major challenge in head trauma patients, since malnutrition cannot be reversed by standard enteral nutrition. We hypothesized that an oligomeric formula could improve nutritional status by restoring intestinal trophicity. Eighteen male Sprague-Dawley rats (300-330 g) underwent gastrostomy (D-7) and Traumatic Brain injury (TBI) by hydraulic ...
Foo Reuben - - 2012
PURPOSE: To investigate patients' attitudes and perceptions towards a subconjunctival implant as a novel ocular drug delivery method for glaucoma. METHODS: 344 Chinese patients with primary open angle or angle closure glaucoma currently on topical anti-glaucoma medication for a minimum of six months were recruited from specialist glaucoma clinics. Socio-demographic ...
Bettencourt Amie - - 2012
This study identified classes of adolescents who differed in their patterns of reported aggression and victimization, examined the stability of these patterns, and explored factors associated with changes in patterns across time. Participants were 477 students from an urban and an adjoining county school system. The overall sample was 48% ...
Studer Philipp - - 2012
We report that solitary bismuth and antimony atoms, incorporated at Si(111) surfaces, induce either positive or negative charge states depending on the site of the surface reconstruction in which they are located. This is in stark contrast to the hydrogenic donors formed by group V atoms in silicon bulk crystal ...
González Besteiro Marina A MA Department of Botany and Plant Biology, University of Geneva, Sciences III, CH-1211 Geneva 4, - - 2013
MAP kinase phosphatases (MKPs) are important regulators of the activation levels and kinetics of MAP kinases. This is crucial for a large number of physiological processes during development and growth, as well as interactions with the environment, including the response to ultraviolet-B (UV-B) stress. Arabidopsis MKP1 is a key regulator ...
Wang Zhihui Z Department of Pathology, University of New Mexico, Albuquerque, NM, - - 2013
Cancer systems biology is an interdisciplinary, rapidly expanding research field in which collaborations are a critical means to advance the field. Yet the prevalent database technologies often isolate data rather than making it easily accessible. The Semantic Web has the potential to help facilitate web-based collaborative cancer research by presenting ...
Ortuño Anna - - 2012
Abstract Rickettsia slovaca is the etiological agent of the human disease tick-borne lymphadenopathy (TIBOLA) transmitted by Dermacentor spp. ticks. In our area, Dermacentor marginatus is the most important tick vector; adult ticks feed on mammals, especially ungulates such as wild boars and domestic ruminants. The epidemiology of tick-transmitted diseases describes ...
Lan Jin - - 2012
In this work, we studied ac responses of T-stub structures that are composed of armchair and zigzag graphene ribbons. Compared with uniform graphene ribbons, the T-stub structures show extraordinary properties. The ac responses of armchair and zigzag T-stub structures show different behaviors for different edge configurations. The imaginary part of ...
Daly John - - 2012
Brain-machine interfaces (BMIs) aim to restore lost sensorimotor and cognitive function in subjects with severe neurological deficits. In particular, lost somatosensory function may be restored by artificially evoking patterns of neural activity through microstimulation to induce perception of tactile and proprioceptive feedback to the brain about the state of the ...
Mace John H - - 2012
The goal of this study was to show that voluntary autobiographical memories could be primed by the prior activation of autobiographical memories. Three experiments demonstrated voluntary memory priming with three different approaches. In Experiment 1 primed participants were asked to recall memories from their elementary school years. In a subsequent ...
Davis T S TS Department of Bioengineering, University of Utah, Salt Lake City, UT, - - 2012
It has been hypothesized that a vision prosthesis capable of evoking useful visual percepts can be based upon electrically stimulating the primary visual cortex (V1) of a blind human subject via penetrating microelectrode arrays. As a continuation of earlier work, we examined several spatial and temporal characteristics of V1 microstimulation. ...
Kakisu Emiliano - - 2012
Kefir is a fermented-milk beverage originating and widely consumed in the Caucasus as well as in Eastern Europe and is a source of bacteria with potential probiotic properties. Enterohaemorrhagic Escherichia coli producing Shiga toxin is commonly associated with food-transmitted diseases; the most prevalent serotype causing epidemics is Esch. coli O157:H7. ...
Rieder E - - 2012
Background and study aims: Gastrointestinal stents have become an important therapeutic option for several indications. However, migration in up to 40 % of cases represents a significant drawback, especially when covered prostheses are used. We hypothesized that a novel endoscopic suturing device could enable endoluminal stent fixation, which might increase attachment ...
Gogiel Tomasz - - 2012
The extracellular matrix components are differentially distributed among various structures of the umbilical cord. Wharton's jelly is especially rich in collagens and growth factors. Cathepsin B is a major cysteine protease involved in collagen degradation, as well as in the activation of precursor forms of other collagenolytic enzymes and growth ...
Sharma Akhilesh K - - 2012
The stereocontrolling transition state (TS) models for C-C bond formation relying on hydrogen bonding have generally been successful in proline-catalyzed aldol, Mannich, α-amination, and α-aminoxylation reactions. However, the suitability of the hydrogen-bonding model in protic and aprotic conditions as well as under basic and base-free conditions has not been well ...
Guo Zhuojun - - 2012
Elongation factor-G-catalyzed translocation of mRNA and tRNAs during protein synthesis involves large-scale conformational changes in the ribosome. Formation of hybrid-state intermediates is coupled to counterclockwise (forward) rotation of the body of the 30S subunit. Recent structural studies implicate intrasubunit rotation of the 30S head in translocation. Here, we observe rotation ...
Rajagopal Sangeerthana - - 2012
Most patients with Tourette syndrome report characteristic sensory experiences (premonitory urges) associated with the expression of tic symptoms. Despite the central role of these experiences to the clinical phenomenology of Tourette syndrome, little is known about their underlying brain processes. In the present article we present the results of a ...
Lavagnino Michael - - 2012
Tendon laxity following injury, cyclic creep, or repair has been shown to alter the normal homeostasis of tendon cells which can lead to degenerative changes in the extra-cellular matrix. While tendon cells have been shown to have an inherent contractile mechanism which gives them some ability to re-tighten lax tendons ...
Tahayori Bahman - - 2012
The validity of approximate equations describing the membrane potential under extracellular electrical stimulation (Meffin et al 2012 J. Neural Eng. 9 065005) is investigated through finite element analysis in this paper. To this end, the finite element method is used to simulate a cylindrical neurite under extracellular stimulation. Laplace's equations ...
Lapouge Gaëlle G IRIBHM, Université Libre de Bruxelles, Brussels, - - 2012
Cancer stem cells have been described in various cancers including squamous tumours of the skin by their ability to reform secondary tumours upon transplantation into immunodeficient mice. Here, we used transplantation of limiting dilution of different populations of FACS-isolated tumour cells from four distinct mouse models of squamous skin tumours ...
Locatis Craig C National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. - - 2013
The Agency for Healthcare Research and Quality sponsored two telemedicine research reviews. The latest review concluded that telemedicine is most relevant to specialties, such as psychiatry and neurology, where high levels of patient interaction are crucial to assessment. Telemedicine research studies cited in the reviews having positive findings in the ...
Wirges Markus - - 2012
Incorporation of an active pharmaceutical ingredient (API) into the coating layer of film-coated tablets is a method mainly used to formulate combination tablets. Uniform and precise spray coating of an API represents, however, a substantial challenge that could be overcome by applying Raman spectroscopy as process analytical tool. In the ...
Song Bing B Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, - - 2013
Although gemcitabine is the standard chemotherapeutic drug for treatment of pancreatic cancer, almost all patients eventually develop resistance to this agent. Previous studies identified Polo-like kinase 1 (Plk1) as the mediator of gemcitabine resistance, but the molecular mechanism remains unknown. In this study, we show that Plk1 phosphorylation of Orc2 ...
Hong Ying - - 2012
ABSTRACT Purpose: To study the possible mechanism and treatment for pigment dispersion glaucoma (PDG) caused by single-piece acrylic (SPA) intraocular lens (IOL) ciliary sulcus fixation in Asian eyes. Materials and methods: Patients referred for PDG caused by SPA IOL ciliary sulcus fixation to our hospital from April 2005 to June ...
Pioche M - - 2012
Severe (stage IV) duodenal polyposis is difficult to manage in patients with familial adenomatous polyposis (FAP), with no effective medical treatment, complex endoscopic treatment modalities, and a high morbidity and mortality from pancreaticoduodenectomy. We present the case of a 44-year-old woman with FAP, stage IV duodenal polyposis, and with an ...
Larsen Lois - - 2012
Objective: The menstrual pictogram (MP), a semiquantitative, easy-to-use tool to assess blood loss, was validated against the reference standard of alkaline hematin (AH) quantitation using data pooled from 3 clinical trials. Methods: Premenopausal women aged ≥18 years with heavy menstrual bleeding (HMB) associated with uterine leiomyomata were randomized to asoprisnil ...
Tang Guangsheng - - 2012
Through the one-step plasma oxidation of TiN thin films at room temperature (a simple semiconductor technology compatible method), a partly oxidised structure of titanium oxynitride (TiN(x)O(y)) with a TiO(2-x) nanolayer on top has been prepared for non-volatile resistive switching memory devices. The fabricated Pt/TiO(2-x)/TiN(x)O(y)/TiN memory devices demonstrate complementary resistive switching ...
Mauger Stefan J - - 2012
Noise-reduction methods have provided significant improvements in speech perception for cochlear implant recipients, where only quality improvements have been found in hearing aid recipients. Recent psychoacoustic studies have suggested changes to noise-reduction techniques specifically for cochlear implants, due to differences between hearing aid recipient and cochlear implant recipient hearing. An ...
Italiano Dafne D Department of Experimental Medicine and Surgery, University of Tor Vergata, Rome, - - 2012
Analysis of microarrays performed in p53-, TAp63α- and ΔNp63α-inducible SaOs-2 cell lines allowed the identification of NCF2 mRNA upregulation in response to p53 induction. NCF2 gene encodes for p67phox, the cytosolic subunit of the NADPH oxidase enzyme complex. The recruitment of p67phox to the cell membrane causes the activation of ...
Furtado Amanda M B - - 2012
With the prevalence of air quality issues in our society, the ability to remove toxic gases from air is a necessity. This work addresses the development of biphasic, nanostructured, organoalkoxysilane-grafted, siliceous materials for use in single pass filters of various types for the removal of acidic and basic gases from ...
Brockington Sf - - 2012
Differentiated epidermal cells such as trichomes and conical cells perform numerous essential functions in plant biology and are important for our understanding of developmental patterning and cell shape regulation. Many are also commercially significant, such as cotton fibers and trichomes that secrete pharmaceutically useful or herbivore-deterring compounds. Here we focus ...
Matmor Maayan - - 2012
The use of proteins and peptides as part of biosensors and electronic devices has been the focus of intense research in recent years. However, despite the fact that the interface between the bioorganic molecules and the inorganic matter plays a significant role in determining the properties of such devices, information ...
Mokart D - - 2012
Abstract Acute respiratory failure (ARF) is the leading reason for ICU admission in cancer patients. The aim of this study was to identify early predictors of death in cancer patients admitted to the ICU for ARF who were not intubated at admission. We realized the analysis of a prospective randomized ...
Ikuma Naohiko - - 2012
Variously substituted [6,6]closed aziridinofullerenes were exclusively obtained from acid-catalyzed denitrogenation of triazolinofullerenes without formation of relevant [5,6]open azafulleroids, which are the major products on noncatalyzed denitrogenation. The mechanistic consideration by DFT calculations suggested a reaction sequence involving initial pre-equilibrium protonation of the triazoline N(1) atom, generation of aminofullerenyl cation by ...
Warner Marc - - 2012
Nanostructure and molecular orientation play a crucial role in determining the functionality of organic thin films. In practical devices, such as organic solar cells consisting of donor-acceptor mixtures, crystallinity is poor and these qualities cannot be readily determined by conventional diffraction techniques, while common microscopy only reveals surface morphology. Using ...
Mami-Chouaib Fathia - - 2012
T-cell adhesion/costimulatory molecules and their cognate receptors on target cells play a major role in T-cell receptor (TCR)-mediated activities. Here, we compared the involvement of CD103 and LFA-1, and their respective ligands, in maturation of the cytotoxic immune synapse (cIS) and in activation of CTL effector functions. Our results indicate ...
Feeley Nancy - - 2012
Aims and objectives.  To explore what fathers perceive to be facilitators or barriers to their involvement with their infants. Background.  Fathers make unique and important contributions to the development of their infants. Fathers of infants in the neonatal intensive care unit often feel that they have a limited role to ...
Maga John A - - 2013
We have used a peptide-based targeting system to improve lysosomal delivery of acid α-glucosidase (GAA), the enzyme deficient in patients with Pompe disease. Human GAA was fused to the glycosylation-independent lysosomal targeting (GILT) tag, which contains a portion of insulin-like growth factor II, to create an active, chimeric enzyme with ...
Xu Su-Xia - - 2012
A cascade AgOTf-catalyzed chemoselective approach to 3,5/1,3-disubstitued pyrazoles from propargylic alcohols and para-tolylsulfonohydrazide has been developed. Good chemoselectivity is observed depending on the different substituents in the alkyne moiety of the propargylic alcohols, generating two different kinds of products through different aromatization mechanisms. The pyrazolo[5,1-a]isoquinoline skeleton can also be effectively ...
Kierans Andrea S - - 2012
PURPOSE: To establish the utility of apparent diffusion coefficient (ADC) entropy in discrimination of benign and malignant adnexal lesions, using histopathology as the reference standard, via comparison of the diagnostic performance of ADC entropy with mean ADC and with visual assessments of adnexal lesions on conventional and diffusion-weighted sequences. MATERIALS ...
Kemp Louise E - - 2012
Rhoptries are club-shaped secretory organelles located at the anterior pole of species belonging to the phylum of Apicomplexa. Parasites of this phylum are responsible for a huge burden of disease in humans and animals and a loss of economic productivity. Members of this elite group of obligate intracellular parasites include ...
Ibrahim Imad - - 2012
Our understanding of the catalyst-free growth of single walled carbon nanotubes (SWNT) by chemical vapour deposition is limited. Toward improving our knowledge-base we conducted systematic investigations into the initial preparation of C60 fullerenes as nucleation precursors for single wall, and even double wall carbon nanotube fabrication. The role of the ...
Lazo Edward - - 2012
The IRPA13 Congress took place from 14-18 May 2012 in Glasgow, Scotland, UK, and was attended by almost 1500 radiological protection professionals. The scientific programme of the Congress was designed to capture a snapshot of the profession's views of the current state of knowledge, and of the challenges seen for ...
Zhang Qing-fang - - 2012
Apparent motion quartet is an ambiguous stimulus that elicits bistable perception, with the perceived motion alternating between two orthogonal paths. In human psychophysical experiments, the probability of perceiving motion in each path is greatly enhanced by a brief exposure to real motion along that path. To examine the neural mechanism ...
Kumar Naresh - - 2012
OBJECTIVE: To determine the water sorption, solubility, and resultant change in strength of one microhybrid and two nanofilled resin-based composites (RBCs). METHODS: Water sorption, solubility, and three-point bending strength (TPBS) characteristics of a microhybrid RBC Filtek(™) Z250 (Z250; batch 8MA; shade A3) and two nanofilled RBCs, namely Filtek(™) Supreme XT ...
Chen Wei-Ling WL Graduate Institute of Nursing, Kaohsiung Medical University, Kaohsiung, - - 2013
Patients suffering from congestive heart failure (CHF) frequently feel physical suffering and anxiety. The researchers investigated whether back massage could reduce anxiety, discomfort, and physical suffering in patients with CHF. The effects of gender and severity-dependent response of back massage on anxiety and discomfort in patients were also analyzed. The ...
Lane Wendy S - - 2012
Objective: To evaluate the long-term efficacy and safety of U-500 insulin via continuous subcutaneous insulin infusion (CSII) in patients with insulin-resistant type 2 diabetes and high insulin requirements.Methods: We retrospectively reviewed the effects of U-500 insulin via CSII on durability of glycemic control (HbA1c), body weight, total daily insulin dose ...
Vreeman Rachel C - - 2012
BACKGROUND: There are 2.3 million children living with HIV worldwide, almost 90 % of whom live in sub-Saharan Africa. Access to antiretroviral therapy (ART) for HIV treatment has dramatically increased in resource-limited settings in recent years and allows more HIV-infected children to survive into adolescence and adulthood. PURPOSE: Our objective ...
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