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Silva-Herdade A S - - 2012
Acetylcholinesterase (AChE) is found both on the membranes of neuronal and non-neuronal cells. In this study we performed intravenous administrations of velnacrine (VLN) and acetylcholine (ACh), respectively, AChE inhibitor and substrate, in an animal model of lipopolysaccharide (LPS)-induced inflammation in Wistar rats. Using intravital microscopy the number of rolling and ...
De Wilde Kirsten - - 2012
Among the many plant-based production systems that are being tested for molecular farming, seeds are very attractive as they provide a stable environment in which the accumulating recombinant proteins can be stored. However, it is not known exactly how high production levels of recombinant antibodies influence the endogenous transcriptome and ...
Beetsma Daniel J V - - 2012
Tics in Tourette Syndrome (TS) are often preceded by 'premonitory urges': annoying feelings or bodily sensations. We hypothesized that, by reducing annoyance of premonitory urges, tic behaviour may be reinforced. In a 2X2 experimental design in healthy participants, we studied the effects of premonitory urges (operationalized as air puffs on ...
Siggelkow Wulf - - 2012
ABSTRACT: BACKGROUND: Inhibitors targeting the cell cycle-regulated aurora kinase A (AURKA) are currently being developed. Here, we examine the prognostic impact of AURKA in node-negative breast cancer patients without adjuvant systemic therapy (n = 766). METHODS: AURKA was analyzed using microarray-based gene-expression data from three independent cohorts of node-negative breast ...
Levetan Claresa S - - 2012
Objective: To elucidate for clinical endocrinologists why diabetes is so difficult to treat despite the present tools and pharmacological armamentarium and to provide insights into emerging therapies including human and rodent data demonstrating the ability to transform progenitor cells that reside within the adult pancreas into new islets.Methods: Review of ...
Gruber Andreas R - - 2012
In eukaryotes, the 3' ends of RNA polymerase II-transcribed RNAs are generated in the majority of cases by site-specific endonucleolytic cleavage, followed by the addition of a poly(A) tail. Through alternative polyadenylation, a gene can give rise to multiple mRNA isoforms that differ in the length of their 3' UTRs ...
Yan Jixian - - 2012
A simple, low-cost, and sensitive 3D microfluidic origami electrochemiluminescence aptamer-device was developed based on a novel gold nanoparticle modified porous paper working electrode for point-of-care diagnosis.
Halboos A - - 2012
History and clinical findings: A 69-year-old man came to the emergency unit because of vertigo and presyncope. A bipolar disorder - known since an age of 15 years - has been treated with 2 × 450 mg lithium and 100 mg perazine per day for several years (no other medications). With the ...
Bonnet Françoise - - 2012
ABSTRACT: BACKGROUND: Despite entering complete remission after primary treatment, a substantial proportion of patients with early stage breast cancer will develop metastases. Prediction of such an outcome remains challenging despite the clinical use of several prognostic parameters. Several reports indicate that genomic instability, as reflected in specific chromosomal aneuploidies and ...
Branthwaite Helen - - 2012
Modern footwear has been associated with the development of foot pain and pathology in the ageing adult. Yet this foot health issue does not seem to alter the footwear purchases made by younger women. In total, 162 teenage girls were questioned regarding shoes purchased over a 6-month period. The results ...
Mesters Ilse - - 2012
Abstract Infants of parents with a history of asthma could benefit from exclusive breastfeeding during the first 6 months of life to reduce the chance of developing childhood asthma. Continuing to breastfeed for 6 months seemed difficult to perform for many Dutch women. Therefore, an educational breastfeeding program was developed ...
White Peter - - 2012
Dosimetric comparisons between RapidArc (RA) and conventional Intensity-Modulated Radiation Therapy (IMRT) techniques for nasopharyngeal carcinoma (NPC) were performed to address differences in dose coverage of the target, sparing of organs-at-risk (OARs), delivery of monitor units (MUs) and time, to assess whether the RA technique was more beneficial for treatment of ...
Mochizuki Yasuhiro Y Department of Molecular Biology and Medicine, The University of Tokyo, Tokyo 153-8904, Japan. - - 2013
A large family of myotubularin phosphatases dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, which are known to play important roles in vesicular trafficking and autophagy. The family is composed of 16 members, and understanding their regulatory mechanisms is important to understand their functions and related genetic diseases. We prepared anti-myotubularin-related protein ...
Jung M - - 2012
Objectives: To analyze the attitude of physicians towards alertin g in CPOE systems in different hospitals in different countries, addressing various organizational and technical settings and the view of physicians not currently using a CPOE.Methods: A cross-sectional quantitative and qualitative questionnaire survey. We invited 2,600 physicians in eleven hospitals from ...
Buck Patrick M - - 2012
Aggregation is a common hurdle faced during the development of antibody therapeutics. In this study, we explore the potential aggregation liabilities of the Fab (fragment antigen-binding) from a human IgG1κ antibody via multiple elevated temperature molecular dynamic simulations, analogous to accelerated stability studies performed during formulation development. Deformation and solvent ...
Wu Di - - 2012
The construction of coronenes using simple building blocks is a challenging task. In this work, triphenylene was used as a building block to construct functionalized coronenes. Their solid structures and optoelectronic properties were investigated. The single crystal structures showed that coronenes had different packing motifs. Their good solubility and photostability ...
Hamama-Raz Yaira - - 2012
In this study we examined the meaning of being the wife of a vegetative patient over time. The research was based on semistructured interviews with 12 wives of husbands who were diagnosed with persistent vegetative state between 1 year 2 months and 10 years prior to the interview. We found ...
Elamin Ishraga - - 2012
The association between immunity and neurodevelopmental disorders has been extensively investigated in autism, suggesting a potential involvement of both cellular and humoral immunity in the establishment of synaptic connectivity modulation during development. A similar link has been proposed also for Tourette syndrome (TS), a complex, multifactorial disorder, in which the ...
Park Min Bum - - 2012
A solid understanding of the molecular-level mechanisms responsible for zeolite crystallization remains one of the most challenging issues in modern zeolite science. Here, we investigate the formation pathway for high-silica LTA zeolite crystals in the simultaneous presence of tetraethylammonium (TEA+), tetramethylammonium (TMA+), and Na+ ions as structure-directing agents (SDAs) with ...
Maryniak Agnieszka - - 2012
Objectives: To assess the cognitive, social, and emotional function in girls prenatally treated with dexamethasone (Dex) due to congenital adrenal hyperplasia (CAH), compared to CAH female patients not treated prenatally. Patients and methods: 33 girls from CAH families were studied: 17 girls treated prenatally with Dex (9 CAH-affected and 8 ...
Wøien Hilde - - 2012
AIMS AND OBJECTIVES: To assess the effects of introducing a systematic approach to pain and sedation management in the ICU. BACKGROUND: Identification of ICU patients' analgesic and sedative needs decreases the risk of complications and the hospital length of stay. Several studies have reported a lack of systematic assessment. DESIGN ...
Lugaresi Marialuisa - - 2012
OBJECTIVES: The misdiagnosis of short oesophagus may occur on recurrence of the hernia after surgery for type II-IV hiatal hernia (HH). The frequency of short oesophagus in type II-IV hernia is undefined. The aim of this study was to assess the frequency of true short oesophagus in patients undergoing surgery ...
Cirillo Teresa - - 2012
Ready-to-eat meals packed in polyethylene terephthalate (PET) and aluminium dishes, supplied to patients in two hospitals in the Campania region (Italy), were studied to evaluate the probable migration of di-n-butylphthalate (DBP) and di(2-ethylhexyl)phthalate (DEHP) from the packaging into the food. The influence of temperature, storage time and type of package ...
Aboutalebi Amir - - 2012
Vascular anomalies may be appropriately classified into two broad categories, vascular tumors and vascular malformations, which are distinguished by the presence of cellular proliferation in contrast to aberrations in morphogenesis, respectively. This system of classification is based upon histological features that may in large part be differentiating, but nevertheless, may ...
Bouffler Simon - - 2012
This paper presents the response of the Health Protection Agency (HPA) to the 2011 statement from the International Commission on Radiological Protection (ICRP) on tissue reactions and recommendation of a reduced dose limit for the lens of the eye. The response takes the form of a brief review of the ...
Goericke-Pesch Sandra - - 2012
Suppression of oestrus is of major interest in feral cat populations, but also in breeding queens temporarily not intended for breeding. Slow release gonadotropin-releasing hormone (GnRH) agonist implants are a new off-label approach for reproduction control in cats. However, initially, oestrus induction may occur and no data exist regarding what ...
McEwen Gerald D - - 2012
The nanostructures and hydrophobic properties of cancer cell membranes are important for membrane fusion and cell adhesion. They are directly related to cancer cell biophysical properties, including aggressive growth and migration. Additionally, chemical component analysis of the cancer cell membrane could potentially be applied in clinical diagnosis of cancer by ...
Wang Yuhui - - 2012
We report a new upconversion fluorescence resonance energy transfer (UC-FRET) biosensor using poly-m-phenylenediamine (PMPD) nanospheres as the energy acceptor in this paper. A single-stranded DNA (ssDNA) tagged with a sulfydryl group at 5' terminus was covalently linked to poly-ethylenimine (PEI) functionalized upconversion phosphors (UCPs, the energy donor). Because of the ...
Fartashvand M - - 2012
BACKGROUND: Theileria annulata is a blood parasite affecting ruminants. Hemolytic anemia, secondary hypoxia, and vasculitis are the most important features of tropical theileriosis. OBJECTIVES: Evaluation of electrocardiographic findings and changes in cardiovascular biochemical markers including cTnI concentrations in cattle naturally infected with theileriosis in the absence of acute cardiac failure. ...
Evans C John - - 2012
PURPOSE: To compare the repeatability of γ-aminobutyric acid (GABA) measurements using J-difference editing, before and after spectral realignment-a technique which has previously been demonstrated to improve the quality of J-difference GABA spectra. MATERIALS AND METHODS: We performed in vivo measurements in three brain regions (occipital, sensorimotor, and dorsolateral prefrontal cortex ...
Inai Hiromu - - 2012
OBJECTIVE: To elucidate the patterns of and risk factors for deterioration of renal function after chemotherapy in metastatic testicular cancer survivors using the estimated glomerular filtration rate. METHODS: A total of 96 patients who were treated with cisplatin-based chemotherapy for metastatic testicular cancer between January 1981 and December 2010 were ...
Garg Satish K - - 2012
Objective Peripheral insulin resistance in type 1 diabetes may be related to a paradoxical postprandial glucagon increase. This study evaluated the effects of sitagliptin, (DPP-IV inhibitor, approved for patients with type 2 diabetes), in adults with type 1 diabetes to improve glycemic control through decreasing postprandial glucagon.Methods This investigator-initiated, double-blind, ...
Wise Andrew K AK Bionics Institute, 384 Albert Street, East Melbourne 3002, Australia. - - 2012
Bionic devices electrically activate neural populations to partially restore lost function. Of fundamental importance is the functional integrity of the targeted neurons. However, in many conditions the ongoing pathology can lead to continued neural degeneration and death that may compromise the effectiveness of the device and limit future strategies to ...
Richter Gresham T - - 2012
Venous malformations (VMs) frequently occur in the head and neck with a predilection for the parotid gland, submandibular triangle, buccal space, muscles of mastication, lips, and upper aerodigestive tract. They are composed of congenitally disrupted ectatic veins with inappropriate connections and tubular channels. Because VMs have poorly defined boundaries and ...
Faza Olalla Nieto - - 2012
In this work we show that a base is needed to generate the active catalyst through any of three different paths close in energy. The facial differentiation arises from steric interactions that induce a very asynchronous, non-pericyclic disfavored transition state. Catalyst regeneration takes place through two steps that avoid a ...
Posati Tamara - - 2012
Nanosized Layered Double Hydroxides (LDH) were prepared in confined environment through the microemulsion method in the presence of different lanthanide cations (Ln(III) = Eu(III), Yb(III), Tb(III), and Nd(III)). To investigate the effects of lanthanide insertion in the sheets of LDH materials, several samples were prepared upon progressively increasing the content ...
Zhang Man-Li - - 2012
A phytochemical investigation of Chromolaena odorata resulted in the isolation of five new compounds, 5aα,6,9,9aβ,10-pentahydro-10β-hydroxy-7-methylanthra[1,2-d][1,3]dioxol-5-one (1), 1,2-methylenedioxy-6-methylanthraquinone (2), 3-hydroxy-1,2,4-trimethoxy-6-methylanthraquinone (3), 3-hydroxy-1,2-dimethoxy-6-methylanthraquinone (4), and 7-methoxy-7-epi-medioresinol (5), together with 12 known compounds, odoratin (6), 3β-acetyloleanolic acid (7), ursolic acid (8), ombuin (9), 4,2'-dihydroxy-4',5',6'-trimethoxychalcone (10), (-)-pinoresinol (11), austrocortinin (12), tianshic acid (13), cleomiscosin ...
Barczyński M M Third Department of General Surgery, Jagiellonian University Medical College, 37 Pradnicka Street, 31-202 Kraków, Poland. - - 2013
Prophylactic central neck dissection (CND) for papillary thyroid cancer (PTC) remains controversial. The aim of this study was to examine whether prophylactic CND for PTC affected long-term survival and locoregional control. This was a retrospective cohort study of patients who underwent total thyroidectomy (TT) with bilateral prophylactic CND. They were ...
Leontieva Olga V - - 2012
When the cell cycle is arrested, even though growth-promoting pathways such as mTOR are still active, then cells senesce. For example, induction of either p21 or p16 arrests the cell cycle without inhibiting mTOR, which, in turn, converts p21/p16-induced arrest into senescence (geroconversion). Here we show that geroconversion is accompanied ...
Kao Wei-Yu - - 2012
BACKGROUND: Epidemiologic studies have identified cholecystectomy as a possible risk factor for cancers in Western countries. The aim of this study was to estimate the risk of hepato-biliary cancer after cholecystectomy in Taiwan. METHODS: Based on the Taiwan National Health Insurance Research Database, 2,590 cholecystectomized patients without prior cancers in ...
Louie Brian E - - 2012
BACKGROUND: Laparoscopic Nissen fundoplication is comprised of: a wrap thought responsible for the lower esophageal sphincter function and crural closure performed to prevent herniation. We hypothesized gastroesophageal junction competence effected by Nissen fundoplication results from closure of the crural diaphragm and creation of the fundoplication. METHODS: Patients with uncomplicated reflux ...
Carvalho B - - 2012
BACKGROUND: /st>The aim of this study was to determine whether experimental pain tests (EPTs) using heat, pressure, and i.v. cannulation before induction of labour reliably predict epidural analgesic use and pain intensity during labour. METHODS: /st>Fifty healthy women with singleton, term pregnancies admitted for scheduled induction of labour comprised the ...
Wang Xiaojiao - - 2012
Dairy manure (DM), chicken manure (CM) and wheat straw were used to investigate the possibility of optimizing the methane (CH(4)) potentials in anaerobic co-digestion of multiple substrates. Response surface methodology (RSM) was used to evaluate the individual and interactive effects of four variables [carbon/nitrogen (C/N) ratio, the feeding composition (DM/CM), ...
Fang Weijie - - 2012
We report the first atomistic simulation study to characterize poly(ionic liquid) (PIL) membranes and examine their capability for post-combustion CO(2) capture. Four PILs based on 1-vinyl-3-butylimidazolium ([VBIM](+)) are examined with four different anions, namely bis(trifluoromethylsulfonyl)imide ([TF(2)N](-)), thiocyanate ([SCN](-)), hexafluorophosphate ([PF(6)](-)) and chloride ([Cl](-)). Gas molecules (CO(2) and N(2)) in [VBIM](+)-based ...
Sun Yulin - - 2013
To date, the useful markers of hepatocellular carcinoma (HCC) remains incompletely developed. Here, we show that annexin A2 complement alpha-fetoprotein (AFP), a widely used liver cancer marker, in the serologically surveillance and early detection of HCC. First, differentially expressed proteins in HCC were identified using a subcellular proteomic approach. Annexin ...
Bloch Frederic - - 2012
The objective of this study was to analyze whether a meta-analysis could allow us to draw useful conclusions about the risk factors for falls in the elderly. A systematic review was carried out of various databases and completed manually. To satisfy the inclusion criteria, an article had to examine a ...
Kotsyubynskyy Dmytro - - 2012
A computational stochastic approach is applied to the description of flexible molecules. By combining i) molecular dynamics simulations, ii) hydrodynamics approaches and iii) a multidimensional diffusive description for internal and global dynamics, it is possible to build an efficient integrated approach to the interpretation of relaxation processes in flexible systems. ...
Busch F A - - 2012
Photorespiration is a process that competes with photosynthesis, in which Rubisco oxygenates, instead of carboxylates, its substrate ribulose 1,5-bisphosphate. The photorespiratory metabolism associated with the recovery of 3-phosphoglycerate is energetically costly and results in the release of previously fixed CO(2) . The ability to quantify photorespiration is gaining importance as ...
Begum Munni - - 2012
We conducted a meta-analysis to explore dose-response relationships for bladder and lung cancers when people are chronically exposed to low doses of arsenic. We searched electronic databases for articles published through 2010. Ten studies on bladder cancer and ingested arsenic exposure and five studies on lung cancer and ingested arsenic ...
You Changjiang - - 2012
Quantum dots (QD) are powerful labels for probing diffusion and interaction dynamics of proteins on the single molecule level in living cells. Protein cross-linking due to multifunctional QD strongly affects these properties. This becomes particularly critical when labeling interactions partners with QDs for interrogating the dynamics of complexes. We have ...
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