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Bodson Laurent - - 2012
ABSTRACT: In the previous issue of Critical Care, Muller and colleagues investigated whether respiratory variation in inferior vena cava diameter (ΔIVC) could be a useful predictor of fluid responsiveness in spontaneously breathing patients. The study concludes that accuracy was not very good and therefore that this parameter should be used ...
Goldblum David D Department of Ophthalmology, University Hospital Basel, University Basel, 4031, Basel, Switzerland. - - 2013
To report the natural, longitudinal history of shifts in refractive errors in different age groups in a large western European cohort over at least 5 years in the same patients. The electronic database of a large regional clinic containing 225,000 patients was searched for records of patients with a follow-up ...
Hogeveen Jeremy J Department of Psychology and Centre for Cognitive Neuroscience, Wilfrid Laurier University, Waterloo, ON, - - 2013
Imitation is a fundamentally important human capability and has been the topic of considerable research in the behavioural sciences. One paradigm for investigating the basic nature of imitation is the "automatic imitation" paradigm. In this paradigm, participants are symbolically cued to make a particular response, whilst being incidentally exposed to ...
Xiao Meng M Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, PR - - 2013
We developed a reverse line blot (RLB) hybridization-, and rolling circle amplification (RCA)-based assays for the identification of Trichoporon species and evaluated them with 48 isolates that had been previously recognized as belonging to eight species (Trichosporon asahii, T. cutaneum, T. dermatis, T. domesticum, T. inkin, T. japonicum, T. jirovecii, ...
Pfister Roland R Department of Psychology III, Julius-Maximilians University of Würzburg, Röntgenring 11, 97070, Würzburg, Germany. - - 2013
Voluntary actions are guided by sensory anticipations of body-related as well as environment-related action effects. Even though action effects in the environment typically resemble the action goal proper, anticipations of body-related effects can cause interference if they do not correspond to intended environment-related effects. The present study explored which specific ...
Wei Ping P Beijing Key Laboratory of Learning and Cognition, Department of Psychology, Capital Normal University, Beijing, 100048, China. - - 2013
The perceptual load of a given task affects attentional selection, with the selection occurring earlier when the load is high and later when the load is low. Recent evidence suggests that local competitive interaction may underlie the perceptual load effect and determine to what extent a task-irrelevant distractor is processed. ...
KlanĨar Uroš U Lek Pharmaceuticals d.d., Verovškova 57, 1526, Ljubljana, - - 2013
The aim of this work was to establish alternative in vitro dissolution method with good discrimination and in vivo predictability for the evaluation of HPMC extended release matrix tablets. For this purpose, two different HPMC matrix tablet formulations were first evaluated by a range of conventional dissolution testing methods using ...
Barberi Marzia M Department of Anatomy, Histology, Forensic Medicine and Orthopedic, Section of Histology, Sapienza University of Rome, Rome, - - 2012
Down-regulation with gonadodropin-releasing agonist (GnRH-a) protocol during IVF stimulation leads to a severe endogenous LH suppression, which may affect the follicular development. The aim of the study was to evaluate the effects of recombinant LH (r-LH) administration, during late follicular development stages, in recombinant FSH (r-FSH) stimulated cycles on follicular ...
Lund Lars H LH Department of Medicine, Unit of Cardiology, Karolinska Institutet, Stockholm, Sweden. - - 2012
Heart failure with preserved ejection fraction (HFPEF) may be as common and as lethal as heart failure with reduced ejection fraction (HFREF). Three randomized trials of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ie, renin-angiotensin system [RAS] antagonists) did not reach primary end points but may have had selection bias ...
Gaunt Tom R TR MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield Grove, Bristol, UK. - - 2013
Activated partial thromboplastin time (aPTT) is an important routine measure of intrinsic blood coagulation. Addition of activated protein C (APC) to the aPTT test to produce a ratio, provides one measure of APC resistance. The associations of some genetic mutations (eg, factor V Leiden) with these measures are established, but ...
Tonorezos Emily S ES Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, - - 2013
Determine the relationship between diet and metabolic abnormalities among adult survivors of childhood acute lymphoblastic leukemia (ALL). We surveyed 117 adult survivors of childhood ALL using the Harvard Food Frequency Questionnaire. Physical activity energy expenditure (PAEE) was measured with the SenseWear Pro2 Armband. Insulin resistance was estimated using the Homeostasis ...
Gillespie Nathan A NA Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA. - - 2013
We describe the data being collected from the Brisbane Longitudinal Twin Study in Australia as part of the US National Institute on Drug Abuse (NIDA)-funded project, Pathways to Cannabis Use, Abuse and Dependence. The history, recruitment, assessment, and retention of twin families in this project are described in detail, along ...
Terpolilli Nicole A NA Department of Neurosurgery, University of Munich Medical Center, Munich, - - 2013
Ischemia, especially pericontusional ischemia, is one of the leading causes of secondary brain damage after traumatic brain injury (TBI). So far efforts to improve cerebral blood flow (CBF) after TBI were not successful because of various reasons. We previously showed that nitric oxide (NO) applied by inhalation after experimental ischemic ...
Schmidt Peter J PJ Section on Behavioral Endocrinology, National Institute of Mental Health, National Institutes of Health, Department of Health & Human Services, Bethesda, MD 20892-1277, USA. - - 2013
Gynecology clinic-based studies have consistently demonstrated that induced hypogonadism is accompanied by a decline in cognitive test performance. However, a recent study in healthy asymptomatic controls observed that neither induced hypogonadism nor estradiol replacement influenced cognitive performance. Thus, the effects of induced hypogonadism on cognition might not be uniformly experienced ...
Neiman M M Department of Biology, University of Iowa, Iowa City, IA 52242, USA. - - 2013
The predominance of sexual reproduction despite its costs indicates that sex provides substantial benefits, which are usually thought to derive from the direct genetic consequences of recombination and syngamy. While genetic benefits of sex are certainly important, sexual and asexual individuals, lineages, or populations may also differ in physiological and ...
Poitout V V Montreal Diabetes Research Center, CRCHUM, Technopôle Angus, 2901 Rachel Est, Montréal, QC, Canada. - - 2013
The incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic peptide are secreted by enteroendocrine cells and augment glucose-induced insulin secretion in response to food ingestion in a glucose-dependent manner. This mechanism forms the basis for incretin-based therapies in type 2 diabetes. However, the insulinotropic effect of incretins is diminished in type ...
Marina Nephtali N Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, - - 2013
Heart failure may lead to hypoperfusion and hypooxygenation of tissues and this is often exacerbated by central and obstructive sleep apnoeas associated with recurrent episodes of systemic hypoxia which triggers release of ATP within the CNS circuits controlling sympathetic outflow. Using in vitro and in vivo models we tested two ...
Hiranita Takato T Psychobiology Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, - - 2013
Sigma(1) receptors (σ(1)Rs) are intracellularly mobile chaperone proteins implicated in several disease processes, as well as psychiatric disorders and substance abuse. Here we report that although selective σ(1)R agonists (PRE-084, (+)-pentazocine) lacked reinforcing effects in drug-naive rats, over the course of 28 experimental sessions, which was more than sufficient for ...
Modepalli Naresh N Department of Pharmaceutics, The University of Mississippi, 113 Faser Hall, University, Mississippi 38677, - - 2013
Iontophoretic mediated transdermal delivery of ferric pyrophosphate (FPP) in combination with microneedle pretreatment was investigated as a potential treatment for iron deficiency anemia (IDA). In vitro transdermal delivery studies were performed using hairless rat skin and pharmacodynamic studies were performed in hairless anemic rat model. The hematological and biochemical parameters ...
Shunmugavel Anandakumar A Department of Pediatrics, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, - - 2013
Lumbar spinal stenosis (LSS) is the leading cause of morbidity and mortality worldwide. LSS pathology is associated with secondary injury caused by inflammation, oxidative damage and cell death. Apart from laminectomy, pharmacological therapy targeting secondary injury is limited. Statins are FDA-approved cholesterol-lowering drug. They also show pleiotropic anti-inflammatory, antioxidant and ...
Pfaunmiller Erika L EL Department of Chemistry, University of Nebraska, Lincoln, NE 68588-0304, - - 2013
Affinity monolith chromatography (AMC) is a type of liquid chromatography that uses a monolithic support and a biologically related binding agent as a stationary phase. AMC is a powerful method for the selective separation, analysis, or study of specific target compounds in a sample. This review discusses the basic principles ...
Roussouly Pierre P Croix Rouge française CMCR des Massues, 92 rue Edmond Locard, 69005 Lyon, France. - - 2013
Retrospective study of a prospective clinical and radiological database of subjects with adolescent (AIS) and adult (AS) idiopathic scoliosis undergoing surgical correction by posterior approach. To evaluate the differences in sagittal alignment of the spine and pelvis in AIS and AS before surgery and changes after surgery in both populations. ...
Deans Zuzana Z Department of Community Based Medicine, Centre for Ethics in Medicine, University of Bristol, Bristol, - - 2013
Non-invasive prenatal testing for single gene disorders is now clearly on the horizon. This new technology offers obvious clinical benefits such as safe testing early in pregnancy. Before widespread implementation, it is important to consider the possible ethical implications. Four hypothetical scenarios are presented that highlight how ethical ideals of ...
Tenlen Jennifer R JR Department of Biology, University of North Carolina-Chapel Hill, NC 27599, USA. - - 2013
How morphological diversity arises is a key question in evolutionary developmental biology. As a long-term approach to address this question, we are developing the water bear Hypsibius dujardini (Phylum Tardigrada) as a model system. We expect that using a close relative of two well-studied models, Drosophila (Phylum Arthropoda) and Caenorhabditis ...
Zeng K K Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK. - - 2013
There is increasing evidence that background selection, the effects of the elimination of recurring deleterious mutations by natural selection on variability at linked sites, may be a major factor shaping genome-wide patterns of genetic diversity. To accurately quantify the importance of background selection, it is vital to have computationally efficient ...
Vigueira C C CC Department of Biology, Washington University, St Louis, MO, - - 2013
Weeds are among the greatest pests of agriculture, causing billions of dollars in crop losses each year. As crop field management practices have changed over the past 12 000 years, weeds have adapted in turn to evade human removal. This evolutionary change can be startlingly rapid, making weeds an appealing system ...
Koller Heiko H German Scoliosis Center, Werner Wicker Clinic, Im Kreuzfeld 4, 34537 Bad Wildungen, Germany. - - 2013
With progression of cervicothoracic kyphosis (CTK), ankylosing spondylitis (AS) patients suffer functional disability. Surgical correction still poses neurologic risks, while evidence of an ideal technique preventing its complications is weak. We report our results with non-instrumented correction in perspective of a review of literature, serving as an important historical control. ...
Temple Jeff R JR Behavioral Health and Research, Department of Ob/Gyn, UTMB Health, Galveston, TX 77555-0587, USA. - - 2013
The prevention of teen dating violence is a major public health priority. However, the dearth of longitudinal studies makes it difficult to develop programs that effectively target salient risk factors. Using a school-based sample of ethnically diverse adolescents, this longitudinal study examined whether substance use (alcohol, marijuana, and hard drugs) ...
Deng Gary G Integrative Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. - - 2013
Postoperative ileus (POI) prolongs hospital stay and increases risk of postoperative complications. We conducted a randomized, sham-controlled trial to evaluate whether acupuncture reduces POI more effectively than sham acupuncture. Colon cancer patients undergoing elective colectomy were randomized to receive 30 min of true or sham acupuncture twice daily during their first ...
Warner Marc - - 2012
Nanostructure and molecular orientation play a crucial role in determining the functionality of organic thin films. In practical devices, such as organic solar cells consisting of donor-acceptor mixtures, crystallinity is poor and these qualities cannot be readily determined by conventional diffraction techniques, while common microscopy only reveals surface morphology. Using ...
Mami-Chouaib Fathia - - 2012
T-cell adhesion/costimulatory molecules and their cognate receptors on target cells play a major role in T-cell receptor (TCR)-mediated activities. Here, we compared the involvement of CD103 and LFA-1, and their respective ligands, in maturation of the cytotoxic immune synapse (cIS) and in activation of CTL effector functions. Our results indicate ...
Feeley Nancy - - 2012
Aims and objectives.  To explore what fathers perceive to be facilitators or barriers to their involvement with their infants. Background.  Fathers make unique and important contributions to the development of their infants. Fathers of infants in the neonatal intensive care unit often feel that they have a limited role to ...
Park Young-Ho - - 2012
Aims: Coupled responses of mutated K-ras and oxidative stress are often an important etiological factor in non-small-cell lung cancer (NSCLC). However, relatively few studies have examined the control mechanism of oxidative stress in oncogenic K-ras-driven NSCLC progression. Here, we studied whether the redox signaling pathway governed by peroxiredoxin I (Prx ...
Xu Su-Xia - - 2012
A cascade AgOTf-catalyzed chemoselective approach to 3,5/1,3-disubstitued pyrazoles from propargylic alcohols and para-tolylsulfonohydrazide has been developed. Good chemoselectivity is observed depending on the different substituents in the alkyne moiety of the propargylic alcohols, generating two different kinds of products through different aromatization mechanisms. The pyrazolo[5,1-a]isoquinoline skeleton can also be effectively ...
Kierans Andrea S - - 2012
PURPOSE: To establish the utility of apparent diffusion coefficient (ADC) entropy in discrimination of benign and malignant adnexal lesions, using histopathology as the reference standard, via comparison of the diagnostic performance of ADC entropy with mean ADC and with visual assessments of adnexal lesions on conventional and diffusion-weighted sequences. MATERIALS ...
Kemp Louise E - - 2012
Rhoptries are club-shaped secretory organelles located at the anterior pole of species belonging to the phylum of Apicomplexa. Parasites of this phylum are responsible for a huge burden of disease in humans and animals and a loss of economic productivity. Members of this elite group of obligate intracellular parasites include ...
Ibrahim Imad - - 2012
Our understanding of the catalyst-free growth of single walled carbon nanotubes (SWNT) by chemical vapour deposition is limited. Toward improving our knowledge-base we conducted systematic investigations into the initial preparation of C60 fullerenes as nucleation precursors for single wall, and even double wall carbon nanotube fabrication. The role of the ...
Lazo Edward - - 2012
The IRPA13 Congress took place from 14-18 May 2012 in Glasgow, Scotland, UK, and was attended by almost 1500 radiological protection professionals. The scientific programme of the Congress was designed to capture a snapshot of the profession's views of the current state of knowledge, and of the challenges seen for ...
Kumar Naresh - - 2012
OBJECTIVE: To determine the water sorption, solubility, and resultant change in strength of one microhybrid and two nanofilled resin-based composites (RBCs). METHODS: Water sorption, solubility, and three-point bending strength (TPBS) characteristics of a microhybrid RBC Filtek(™) Z250 (Z250; batch 8MA; shade A3) and two nanofilled RBCs, namely Filtek(™) Supreme XT ...
Chen Wei-Ling - - 2012
Abstract Background: Patients suffering from congestive heart failure (CHF) frequently feel physical suffering and anxiety. Objectives: The researchers investigated whether back massage could reduce anxiety, discomfort, and physical suffering in patients with CHF. The effects of gender and severity-dependent response of back massage on anxiety and discomfort in patients were ...
Lane Wendy S - - 2012
Objective: To evaluate the long-term efficacy and safety of U-500 insulin via continuous subcutaneous insulin infusion (CSII) in patients with insulin-resistant type 2 diabetes and high insulin requirements.Methods: We retrospectively reviewed the effects of U-500 insulin via CSII on durability of glycemic control (HbA1c), body weight, total daily insulin dose ...
Vreeman Rachel C - - 2012
BACKGROUND: There are 2.3 million children living with HIV worldwide, almost 90 % of whom live in sub-Saharan Africa. Access to antiretroviral therapy (ART) for HIV treatment has dramatically increased in resource-limited settings in recent years and allows more HIV-infected children to survive into adolescence and adulthood. PURPOSE: Our objective ...
Yilmaz Serkan - - 2012
In vitro genotoxic effects of antioxidant additives, such as citric acid (CA) and phosphoric acid (PA) and their combination, as well as antimicrobial additives, such as benzoic acid (BA) and calcium propionate (CP), on human lymphocytes were determined using alkaline single-cell gel electrophoresis. There was a significant increase in the ...
Behr J - - 2012
Idiopathic pulmonary fibrosis (IPF), a manifestation of chronic progressive fibrosing interstitial pneumonia, is with a prevalence of 2-29 cases per 100,000 individuals a rare disease. Current treatment options are limited, and the mean survival time of the newly diagnosed (mostly elderly) patients is only about 2-3 years. As in Europe ...
Conroy Dominic - - 2012
This study adopted a discursive approach to explore how not drinking alcohol (non-drinking) is construed in relation to masculine identity among 12 undergraduate interviewees. Three prominent discourses were revealed. First, non-drinking was constructed as something strange requiring explanation. Second, contradictory discourses constructed non-drinking as, simultaneously, unsociable yet reflective of greater ...
Kroon Jeroen - - 2012
OBJECTIVE: To investigate opinions and concerns of Gold Coast residents regarding fluoridation of community water supplies. MATERIAL AND METHODS: Anonymous data were collected in four major shopping centers from approximately 500 Gold Coast residents. RESULTS: Eighty-one percent of participants were aware of the addition of fluoride to the water supply. ...
Watkins Harriet A - - 2012
Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides. It is a widely distributed neuropeptide implicated in conditions such as neurogenic inflammation. With other members of the calcitonin family, it shares an N-terminal disulphide-bonded ring which is essential for biological activity, an area of potential alpha ...
Wang Xiao L - - 2012
To build a sustainable workforce for long-term disaster relief and reconstruction, more effort must be made to promote local relief workers' mental health. We conducted 25 semistructured interviews with local relief officials 10 months after the 2008 earthquake in China to investigate the stress and coping experiences in their personal ...
Schobert Charles S - - 2012
OBJECTIVE: Troglomorphic fishes provide excellent comparative models for studying eye evolution. We describe the gross and microscopic anatomy of ocular structures of the depigmented, blind cichlid, Lamprologus lethops, and its putative sister species, Lamprologus tigripictilis collected from the lower Congo River in the Democratic Republic of Congo. PROCEDURES: Both species ...
Marin Virna - - 2012
Use of adoptive T-cell therapy (ACT) is increasing; however T-cell therapy can result in severe toxicity. Consequently, several suicide-gene strategies which allow selective destruction of the infused T-cells have been described. We compared effectiveness of four such strategies in vitro in EBV-CTLs. Herpes Simplex Virus Thymidine Kinase (HSV-TK), human inducible ...
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