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Arishima Hidetaka - - 2012
Amputation neuromas typically arise in injured peripheral nerves; rarely, however, they arise in the spinal cord. We report a rare case of intramedullary amputation neuroma associated with ependymoma in the cervical spinal cord. A 73-year-old woman presented with a 5-year history of progressive gait disturbance. Neurological examination revealed complete motor ...
Misterska Ewa - - 2012
PURPOSE: In the presented study, we aimed to assess changes over time in the perception of trunk deformity, body function, stress level and mental health in females with adolescent idiopathic scoliosis (AIS) who were treated conservatively with a Cheneau brace, taking the Trunk Appearance Perception Scale (TAPS), Scoliosis Research Society-22 ...
Gottlieb Roberta A - - 2012
Whether an element of routine housekeeping or in the setting of imminent disaster, it is a good idea to get one's affairs in order. Autophagy, the process of recycling organelles and protein aggregates, is a basal homeostatic process and an evolutionarily conserved response to starvation and other forms of metabolic ...
Bodson Laurent - - 2012
ABSTRACT: In the previous issue of Critical Care, Muller and colleagues investigated whether respiratory variation in inferior vena cava diameter (ΔIVC) could be a useful predictor of fluid responsiveness in spontaneously breathing patients. The study concludes that accuracy was not very good and therefore that this parameter should be used ...
Goldblum David D Department of Ophthalmology, University Hospital Basel, University Basel, 4031, Basel, Switzerland. - - 2013
To report the natural, longitudinal history of shifts in refractive errors in different age groups in a large western European cohort over at least 5 years in the same patients. The electronic database of a large regional clinic containing 225,000 patients was searched for records of patients with a follow-up ...
Hogeveen Jeremy J Department of Psychology and Centre for Cognitive Neuroscience, Wilfrid Laurier University, Waterloo, ON, - - 2013
Imitation is a fundamentally important human capability and has been the topic of considerable research in the behavioural sciences. One paradigm for investigating the basic nature of imitation is the "automatic imitation" paradigm. In this paradigm, participants are symbolically cued to make a particular response, whilst being incidentally exposed to ...
Xiao Meng M Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, PR - - 2013
We developed a reverse line blot (RLB) hybridization-, and rolling circle amplification (RCA)-based assays for the identification of Trichoporon species and evaluated them with 48 isolates that had been previously recognized as belonging to eight species (Trichosporon asahii, T. cutaneum, T. dermatis, T. domesticum, T. inkin, T. japonicum, T. jirovecii, ...
Pfister Roland R Department of Psychology III, Julius-Maximilians University of Würzburg, Röntgenring 11, 97070, Würzburg, Germany. - - 2013
Voluntary actions are guided by sensory anticipations of body-related as well as environment-related action effects. Even though action effects in the environment typically resemble the action goal proper, anticipations of body-related effects can cause interference if they do not correspond to intended environment-related effects. The present study explored which specific ...
Wei Ping P Beijing Key Laboratory of Learning and Cognition, Department of Psychology, Capital Normal University, Beijing, 100048, China. - - 2013
The perceptual load of a given task affects attentional selection, with the selection occurring earlier when the load is high and later when the load is low. Recent evidence suggests that local competitive interaction may underlie the perceptual load effect and determine to what extent a task-irrelevant distractor is processed. ...
KlanĨar Uroš U Lek Pharmaceuticals d.d., Verovškova 57, 1526, Ljubljana, - - 2013
The aim of this work was to establish alternative in vitro dissolution method with good discrimination and in vivo predictability for the evaluation of HPMC extended release matrix tablets. For this purpose, two different HPMC matrix tablet formulations were first evaluated by a range of conventional dissolution testing methods using ...
Barberi Marzia M Department of Anatomy, Histology, Forensic Medicine and Orthopedic, Section of Histology, Sapienza University of Rome, Rome, - - 2012
Down-regulation with gonadodropin-releasing agonist (GnRH-a) protocol during IVF stimulation leads to a severe endogenous LH suppression, which may affect the follicular development. The aim of the study was to evaluate the effects of recombinant LH (r-LH) administration, during late follicular development stages, in recombinant FSH (r-FSH) stimulated cycles on follicular ...
Gaunt Tom R TR MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield Grove, Bristol, UK. - - 2013
Activated partial thromboplastin time (aPTT) is an important routine measure of intrinsic blood coagulation. Addition of activated protein C (APC) to the aPTT test to produce a ratio, provides one measure of APC resistance. The associations of some genetic mutations (eg, factor V Leiden) with these measures are established, but ...
Gillespie Nathan A NA Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA. - - 2013
We describe the data being collected from the Brisbane Longitudinal Twin Study in Australia as part of the US National Institute on Drug Abuse (NIDA)-funded project, Pathways to Cannabis Use, Abuse and Dependence. The history, recruitment, assessment, and retention of twin families in this project are described in detail, along ...
Terpolilli Nicole A NA Department of Neurosurgery, University of Munich Medical Center, Munich, - - 2013
Ischemia, especially pericontusional ischemia, is one of the leading causes of secondary brain damage after traumatic brain injury (TBI). So far efforts to improve cerebral blood flow (CBF) after TBI were not successful because of various reasons. We previously showed that nitric oxide (NO) applied by inhalation after experimental ischemic ...
Schmidt Peter J PJ Section on Behavioral Endocrinology, National Institute of Mental Health, National Institutes of Health, Department of Health & Human Services, Bethesda, MD 20892-1277, USA. - - 2013
Gynecology clinic-based studies have consistently demonstrated that induced hypogonadism is accompanied by a decline in cognitive test performance. However, a recent study in healthy asymptomatic controls observed that neither induced hypogonadism nor estradiol replacement influenced cognitive performance. Thus, the effects of induced hypogonadism on cognition might not be uniformly experienced ...
Neiman M M Department of Biology, University of Iowa, Iowa City, IA 52242, USA. - - 2013
The predominance of sexual reproduction despite its costs indicates that sex provides substantial benefits, which are usually thought to derive from the direct genetic consequences of recombination and syngamy. While genetic benefits of sex are certainly important, sexual and asexual individuals, lineages, or populations may also differ in physiological and ...
Poitout V V Montreal Diabetes Research Center, CRCHUM, Technopôle Angus, 2901 Rachel Est, Montréal, QC, Canada. - - 2013
The incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic peptide are secreted by enteroendocrine cells and augment glucose-induced insulin secretion in response to food ingestion in a glucose-dependent manner. This mechanism forms the basis for incretin-based therapies in type 2 diabetes. However, the insulinotropic effect of incretins is diminished in type ...
Hiranita Takato T Psychobiology Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, - - 2013
Sigma(1) receptors (σ(1)Rs) are intracellularly mobile chaperone proteins implicated in several disease processes, as well as psychiatric disorders and substance abuse. Here we report that although selective σ(1)R agonists (PRE-084, (+)-pentazocine) lacked reinforcing effects in drug-naive rats, over the course of 28 experimental sessions, which was more than sufficient for ...
Modepalli Naresh N Department of Pharmaceutics, The University of Mississippi, 113 Faser Hall, University, Mississippi 38677, - - 2013
Iontophoretic mediated transdermal delivery of ferric pyrophosphate (FPP) in combination with microneedle pretreatment was investigated as a potential treatment for iron deficiency anemia (IDA). In vitro transdermal delivery studies were performed using hairless rat skin and pharmacodynamic studies were performed in hairless anemic rat model. The hematological and biochemical parameters ...
Shunmugavel Anandakumar A Department of Pediatrics, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, - - 2013
Lumbar spinal stenosis (LSS) is the leading cause of morbidity and mortality worldwide. LSS pathology is associated with secondary injury caused by inflammation, oxidative damage and cell death. Apart from laminectomy, pharmacological therapy targeting secondary injury is limited. Statins are FDA-approved cholesterol-lowering drug. They also show pleiotropic anti-inflammatory, antioxidant and ...
Pfaunmiller Erika L EL Department of Chemistry, University of Nebraska, Lincoln, NE 68588-0304, - - 2013
Affinity monolith chromatography (AMC) is a type of liquid chromatography that uses a monolithic support and a biologically related binding agent as a stationary phase. AMC is a powerful method for the selective separation, analysis, or study of specific target compounds in a sample. This review discusses the basic principles ...
Roussouly Pierre P Croix Rouge française CMCR des Massues, 92 rue Edmond Locard, 69005 Lyon, France. - - 2013
Retrospective study of a prospective clinical and radiological database of subjects with adolescent (AIS) and adult (AS) idiopathic scoliosis undergoing surgical correction by posterior approach. To evaluate the differences in sagittal alignment of the spine and pelvis in AIS and AS before surgery and changes after surgery in both populations. ...
Zeng K K Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK. - - 2013
There is increasing evidence that background selection, the effects of the elimination of recurring deleterious mutations by natural selection on variability at linked sites, may be a major factor shaping genome-wide patterns of genetic diversity. To accurately quantify the importance of background selection, it is vital to have computationally efficient ...
Vigueira C C CC Department of Biology, Washington University, St Louis, MO, - - 2013
Weeds are among the greatest pests of agriculture, causing billions of dollars in crop losses each year. As crop field management practices have changed over the past 12 000 years, weeds have adapted in turn to evade human removal. This evolutionary change can be startlingly rapid, making weeds an appealing system ...
Koller Heiko H German Scoliosis Center, Werner Wicker Clinic, Im Kreuzfeld 4, 34537 Bad Wildungen, Germany. - - 2013
With progression of cervicothoracic kyphosis (CTK), ankylosing spondylitis (AS) patients suffer functional disability. Surgical correction still poses neurologic risks, while evidence of an ideal technique preventing its complications is weak. We report our results with non-instrumented correction in perspective of a review of literature, serving as an important historical control. ...
Temple Jeff R JR Behavioral Health and Research, Department of Ob/Gyn, UTMB Health, Galveston, TX 77555-0587, USA. - - 2013
The prevention of teen dating violence is a major public health priority. However, the dearth of longitudinal studies makes it difficult to develop programs that effectively target salient risk factors. Using a school-based sample of ethnically diverse adolescents, this longitudinal study examined whether substance use (alcohol, marijuana, and hard drugs) ...
Deng Gary G Integrative Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. - - 2013
Postoperative ileus (POI) prolongs hospital stay and increases risk of postoperative complications. We conducted a randomized, sham-controlled trial to evaluate whether acupuncture reduces POI more effectively than sham acupuncture. Colon cancer patients undergoing elective colectomy were randomized to receive 30 min of true or sham acupuncture twice daily during their first ...
Tenlen Jennifer R JR Department of Biology, University of North Carolina-Chapel Hill, NC 27599, USA. - - 2013
How morphological diversity arises is a key question in evolutionary developmental biology. As a long-term approach to address this question, we are developing the water bear Hypsibius dujardini (Phylum Tardigrada) as a model system. We expect that using a close relative of two well-studied models, Drosophila (Phylum Arthropoda) and Caenorhabditis ...
Warfel J M JM Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, - - 2013
Despite near universal vaccine coverage, the bacterial pathogen Bordetella pertussis has re-emerged as a major public health concern. We recently developed a baboon (Papio anubis) model of pertussis that provides an excellent model of human pertussis. Using this model, the immune response to pertussis was characterized by measuring cytokines in ...
Yan Xiaoyu X Department of Pharmaceutical Sciences School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, 370 Kapoor Hall, Buffalo, New York 14214, - - 2013
The purpose of this study is to demonstrate that the erythroid precursor depletion in bone marrow induced by recombinant human erythropoietin (rHuEPO) treatment may be another contributing factor to erythropoietin hyporesponsiveness. Healthy Wistar rats were given single dose (SD) or multiple doses (MD) of rHuEPO (100 IU/kg). In MD study, ...
Ullmann Urielle U Center for Medical Genetics UZ Brussel Hospital, Vrije Universiteit Brussel, Brussels, Belgium. - - 2013
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant cancer syndrome that is caused by a germline mutation in the MEN1 gene encoding a tumour-suppressor protein, menin. MEN1 causes a combination of endocrine tumours such as parathyroid adenomas, pituitary adenomas, glucagonomas, gastrinomas, insulinomas, adrenocortical adenomas and non-endocrine tumours. We here ...
Marina Nephtali N Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, - - 2013
Heart failure may lead to hypoperfusion and hypooxygenation of tissues and this is often exacerbated by central and obstructive sleep apnoeas associated with recurrent episodes of systemic hypoxia which triggers release of ATP within the CNS circuits controlling sympathetic outflow. Using in vitro and in vivo models we tested two ...
Tonorezos Emily S ES Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, - - 2013
Determine the relationship between diet and metabolic abnormalities among adult survivors of childhood acute lymphoblastic leukemia (ALL). We surveyed 117 adult survivors of childhood ALL using the Harvard Food Frequency Questionnaire. Physical activity energy expenditure (PAEE) was measured with the SenseWear Pro2 Armband. Insulin resistance was estimated using the Homeostasis ...
Arias-Diaz Javier J Instituto de Salud Carlos III (ISCIII), Madrid, Spain. - - 2013
The Spanish regulatory framework for storage of samples for research responds to most issues raised by both researchers and society regarding biobanking. The Spanish regulation currently foresees three possible ways in which these samples are to be handled: (a) gathering for use in a specific project, (b) storage in a ...
El Chehadeh-Djebbar Salima S Centre de Génétique et Centre de Référence Anomalies du Développement et Syndromes Malformatifs, Hôpital d'Enfants, CHU de Dijon, - - 2013
Cohen syndrome (CS) is a rare autosomal recessive condition caused by mutations and/or large rearrangements in the VPS13B gene. CS clinical features, including developmental delay, the typical facial gestalt, chorioretinal dystrophy (CRD) and neutropenia, are well described. CS diagnosis is generally raised after school age, when visual disturbances lead to ...
Villavicencio-Lorini Pablo P Centre for Pediatrics and Adolescent Medicine, University Hospital of Freiburg, Freiburg, - - 2013
Deletions of the chromosomal region 2q37 cause brachydactyly-mental retardation syndrome (BDMR), also known as Albright hereditary osteodystrophy-like syndrome. Recently, histone deacetylase 4 (HDAC4) haploinsufficiency has been postulated to be the critical genetic mechanism responsible for the main clinical characteristics of the BDMR syndrome like developmental delay and behavioural abnormalities in ...
Gogiel Magdalena M Institute of Human Genetics, RWTH Aachen, Pauwelsstrasse 30, Aachen, - - 2013
Uniparental disomy (UPD) of single chromosomes is a well-known molecular aberration in a group of congenital diseases commonly known as imprinting disorders (IDs). Whereas maternal and/or paternal UPD of chromosomes 6, 7, 11, 14 and 15 are associated with specific IDs (Transient neonatal diabetes mellitus, Silver-Russell syndrome, Beckwith-Wiedemann syndrome (BWS), ...
Deans Zuzana Z Department of Community Based Medicine, Centre for Ethics in Medicine, University of Bristol, Bristol, - - 2013
Non-invasive prenatal testing for single gene disorders is now clearly on the horizon. This new technology offers obvious clinical benefits such as safe testing early in pregnancy. Before widespread implementation, it is important to consider the possible ethical implications. Four hypothetical scenarios are presented that highlight how ethical ideals of ...
Koeppen M M Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, - - 2013
Acute lung injury (ALI) is associated with high morbidity and mortality in critically ill patients. At present, the functional contribution of airway mucins to ALI is unknown. We hypothesized that excessive mucus production could be detrimental during lung injury. Initial transcriptional profiling of airway mucins revealed a selective and robust ...
Castellanos Elisabeth E Hereditary Cancer Program, Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Badalona, - - 2013
Neurofibromatosis type 2 (NF2) is an autosomal-dominant disorder affecting about 1:33 000 newborns, mainly characterized by the development of tumors of the nervous system and ocular abnormalities. Around 85% of germline NF2 mutations are point mutations. Among them, ∼25% affect splicing and are associated with a variable disease severity. In the ...
Hernandez Adrian F AF Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA. - - 2012
Aldosterone antagonist therapy for heart failure and reduced ejection fraction has been highly efficacious in randomized trials. However, questions remain regarding the effectiveness and safety of the therapy in clinical practice. To examine the clinical effectiveness of newly initiated aldosterone antagonist therapy among older patients hospitalized with heart failure and ...
Lund Lars H LH Department of Medicine, Unit of Cardiology, Karolinska Institutet, Stockholm, Sweden. - - 2012
Heart failure with preserved ejection fraction (HFPEF) may be as common and as lethal as heart failure with reduced ejection fraction (HFREF). Three randomized trials of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ie, renin-angiotensin system [RAS] antagonists) did not reach primary end points but may have had selection bias ...
Mérie Charlotte C Department of Cardiology, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65, 2900 Hellerup, Denmark. - - 2012
The need for anticoagulation after surgical aortic valve replacement (AVR) with biological prostheses is not well examined. To perform a nationwide study of the association of warfarin treatment with the risk of thromboembolic complications, bleeding incidents, and cardiovascular deaths after bioprosthetic AVR surgery. Through a search in the Danish National ...
Misegades Lara K LK Epidemic Intelligence Service and Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS-C25, Atlanta, GA 30329, USA. - - 2012
In 2010, California experienced its largest pertussis epidemic in more than 60 years; a substantial burden of disease was noted in the 7- to 10-year-old age group despite high diphtheria, tetanus, and acellular pertussis vaccine (DTaP) coverage, indicating the possibility of waning protection. To evaluate the association between pertussis and ...
Shmerling Robert H RH Division of Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. - - 2012
Gout is an ancient disease. Despite significant advances in the understanding of its risk factors, etiology, pathogenesis, prevention, and treatment, millions of people with gout experience repeated attacks of acute arthritis and other complications. The incidence of gout is increasing, most likely reflecting increasing rates of obesity and other lifestyle ...
Coudrillier Baptiste B Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA, - - 2013
This paper presents a computational modeling study of the effects of the collagen fiber structure on the mechanical response of the sclera and the adjacent optic nerve head (ONH). A specimen-specific inverse finite element method was developed to determine the material properties of two human sclera subjected to full-field inflation ...
Liu Su-Hsun SH Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E. Monument St., Suite 2-600, Baltimore, MD, 21287, - - 2013
Higher prevalence of nonalcoholic fatty liver disease (NAFLD) in men and postmenopausal women than in premenopausal women has suggested a potential role of sex hormones in the pathogenesis of the disease. We sought to evaluate the association between oral contraceptive pills (OCP) and NAFLD and to determine whether adiposity mediates ...
Warner Marc - - 2012
Nanostructure and molecular orientation play a crucial role in determining the functionality of organic thin films. In practical devices, such as organic solar cells consisting of donor-acceptor mixtures, crystallinity is poor and these qualities cannot be readily determined by conventional diffraction techniques, while common microscopy only reveals surface morphology. Using ...
Mami-Chouaib Fathia - - 2012
T-cell adhesion/costimulatory molecules and their cognate receptors on target cells play a major role in T-cell receptor (TCR)-mediated activities. Here, we compared the involvement of CD103 and LFA-1, and their respective ligands, in maturation of the cytotoxic immune synapse (cIS) and in activation of CTL effector functions. Our results indicate ...
Feeley Nancy - - 2012
Aims and objectives.  To explore what fathers perceive to be facilitators or barriers to their involvement with their infants. Background.  Fathers make unique and important contributions to the development of their infants. Fathers of infants in the neonatal intensive care unit often feel that they have a limited role to ...
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