Search Results
Results 401 - 450 of 2119
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Naik Ravi - - 2012
A series of (E)-phenoxyacrylic amide derivatives were synthesized and evaluated as hypoxia inducible factor (HIF) 1α inhibitors. The present structure-activity relationship study on this series identified the morpholinoethyl containing ester 4p as a potent inhibitor of HIF-1α under hypoxic conditions (IC(50) = 0.12 μM in a cell-based HRE reporter assay) ...
Jardel Nicolas - - 2012
OBJECTIVE: To report a surgical technique and long-term outcomes of type II atresia ani (AA) and rectovaginal fistula (RvF) correction, using a fistula flap technique in kittens. STUDY DESIGN: Clinical study. ANIMALS: Domestic shorthaired female kittens (n = 6) with type II AA-RvF. METHODS: Diagnosis of type II AA-RvF was ...
Shin Seung-Heon - - 2012
Bee venom (BV) has long been used as an oriental traditional medicine for the control of pain and inflammation. However, BV's anti-inflammatory mechanisms remain unclear. This study aimed to clarify the potential clinical efficacy of BV concerning the anti-inflammatory effect on nasal epithelial cell inflammation. Nasal polyp epithelial cells were ...
Wang Xin - - 2012
Hypertension control rates are unacceptably low in China. The present study demonstrates if a customized, guideline-oriented training program can cost-effectively improve hypertension management in primary healthcare. Four typical community health centers in Beijing were selected and randomized to intervention or control (one urban and one rural each). A sample of ...
Xu Xian-Rong - - 2012
Aim: The purpose of this study was to determine the effects of lutein supplement on serum cytokines, apoE and lipoprotein profiles in early atherosclerosis population.Methods: Early atherosclerosis patients (n= 65) were randomized to receive placebo (A+P, n= 31) or 20 mg/d lutein (A+L, n= 34) for 3 months.Results: Serum lutein ...
Hotchi Junko - - 2012
Aim: Previous studies have revealed that blockade of the renin angiotensin system attenuates plaque vulnerability and reduces cardiovascular events; however, few studies have compared the effects of an angiotensin-converting enzyme inhibitor (ACEI) with an angiotensin receptor blocker (ARB) and evaluated combination therapy. The objective of this study was to compare ...
Rosenkranz Katja - - 2012
Perinatal hypoxic-ischemic brain injury is an important cause of neurological deficits still causing mortality and morbidity in the early period of life. As efficient clinical or pharmaceutical strategies to prevent or reduce the outcome of perinatal hypoxic-ischemic brain damage are limited, the development of new therapies is of utmost importance. ...
Zhu Z-T - - 2012
1. Resibufogenin (1), a major bufadienolide of Chinese medicine Chan Su, had a wide range of pharmacological activities. In present work, the metabolism of 1 in male Sprague-Dawley rats was investigated by identifying the metabolites of resibufogenin excreted in rat bile. 2. Following an oral dose of 60 mg/kg resibufagenin, nine metabolites were ...
Ohnishi Akihiro - - 2012
The aim of this study was to investigate the correlations of severity of osteoarthritis (OA) and serum biomarkers including keratan sulfate (KS), hyaluronic acid (HA), and chondroitin sulfate (CS) 846 epitope. We also investigated the effect of glucosamine and fish collagen peptide (FCP) on OA. OA was induced in 12 ...
Milani Emanuela S - - 2012
Tyrosine phosphorylation plays a fundamental role in mammary gland development. However, the role of specific tyrosine phosphatases in controlling mammary cell fate remains ill defined. We have identified protein tyrosine phosphatase 1B (PTP1B) as an essential regulator of alveologenesis and lactogenesis. PTP1B depletion increased the number of luminal mammary progenitors ...
Belivani Maria - - 2012
Obesity is one of the leading health risk factors worldwide and is associated with several other risk factors and health problems including type 2 diabetes mellitus, cardiovascular disease and malignancies. Current conventional therapeutic strategies for obesity cannot achieve adequate weight control in all patients, so complementary types of treatment are ...
Kristbjornsdottir Oddny K - - 2012
ABSTRACT: BACKGROUND: Limited data is available on sodium (Na) and potassium (K) intake in young children estimated by 24 hour (24h) excretion in urine. The aim was to assess 24h urinary excretion of Na and K in six-year-old children and its relationship with diet quality. METHODS: The study population was ...
Richmond Melanie J - - 2012
This longitudinal study examined how observations of parental general communication style and control with their adolescents predicted changes in negative affect over time for adolescent smokers and nonsmokers. Participants were 9th- and 10th-grade adolescents (N = 111; 56.8% female) who had all experimented with cigarettes and were thus at risk for continued ...
Michael Lewiecki E - - 2012
Suicide is a serious public health concern that is responsible for almost 1 million deaths each year worldwide. It is commonly an impulsive act by a vulnerable individual. The impulsivity of suicide provides opportunities to reduce the risk of suicide by restricting access to lethal means. In the United States, ...
Mesuere Bart - - 2012
The Unipept web application (http://unipept.ugent.be) supports biodiversity analysis of large and complex metaproteome samples using tryptic peptide information obtained from shotgun MS/MS experiments. Its underlying index structure is designed to quickly retrieve all occurrences of a tryptic peptide in UniProtKB records. Taxon-specificity of the tryptic peptide is successively derived from ...
Garcia Ivelitza - - 2012
DEAD-box proteins are believed to participate in the folding of RNA by destabilizing RNA secondary or tertiary structures. Although these proteins bind and hydrolyze ATP, the mechanism for which nucleotide hydrolysis is coupled to helix destabilization may vary among different DEAD-box proteins. To investigate their abilities to disrupt helices and ...
Menheniott Trevelyan R - - 2012
During the past decade, a new family of stomach-specific proteins has been recognized. Now known as 'gastrokines' (GKNs), these secreted proteins are products of gastric mucous producing cell lineages. GKNs are highly conserved in physical structure and emerging data points to convergent functions in the modulation of gastric mucosal homeostasis ...
Clem Brian F - - 2012
The discovery of the retinoblastoma (RB-1) gene as a tumor suppressor that is disrupted in a majority of human cancers either via direct or indirect genetic alterations has resulted in increased interest in its functions and downstream effectors. Although the canonical pathway that links this tumor suppressor to human cancers ...
Wilmont Sibyl Shalo - - 2012
Passion. Courage. Altruism. These are just three of the characteristics common to transformational leaders in public health, according to Linda Fried, MD, MPH, dean of Columbia University's Mailman School of Public Health.(1) As the selection committee chairperson for The Calderone Prize in Public Health, Fried oversees the daunting task of ...
Tijtgat Pieter - - 2012
The purpose of this study was to investigate postural adjustments in one-handed ball catching. Specifically, the functional role of anticipatory postural adjustments (APA) during the initial arm raising and subsequent postural adjustments (SPA) for equilibrium control and ball-hand impact were scrutinized. Full-body kinematics and kinetics allowed an analysis of the ...
Cassio Alessandra - - 2012
Background: TSHR LOF mutations lead to a wide spectrum of phenotypes, ranging from severe congenital hypothyroidism to mild euthyroid hyperthyrotropinemia. The degree of TSH resistance depends on the severity of the impairment of the receptor function caused by the mutation and on the number of mutated alleles. Objective: In this ...
Sugimori Hiroko - - 2012
Increased blood viscosity reduces blood flow and elevates vascular resistance in the cardiovascular system. The aim of this study was to elucidate how blood viscosity could affect renal function and eventually contribute to renal damage in essential hypertensives (EHT). In 164 untreated EHT without apparent renal damage (96 men, 56±12 ...
Costa Lucio G - - 2012
ABSTRACT: Lucio G. Costa is currently Professor of Environmental and Occupational Health Sciences at the School of Public Health at the University of Washington. Dr. Costa is a renowned neurotoxicologist whose research interests are focused on understanding the role of neurotoxic substances in neurodevelopmental disorders and other neurological, neuropsychiatric and ...
Irisarri Iker - - 2012
ABSTRACT: BACKGROUND: Understanding the causes underlying heterogeneity of molecular evolutionary rates among lineages is a long-standing and central question in evolutionary biology. Although several earlier studies showed that modern frogs (Neobatrachia) experienced an acceleration of mitochondrial gene substitution rates compared to non-neobatrachian relatives, no further characterization of this phenomenon was ...
Yoshida Akihito - - 2012
We report the fabrication technique and optical properties of multilayered two-dimensional (2D) gold nanoparticle sheets ('Au nanosheet'). The 2D crystalline monolayer sheet composed of Au nanoparticles shows an absorption peak originating from a localized surface plasmon resonance (LSPR). It was found that the absorption spectra dramatically change when the monolayers ...
Cray L A - - 2012
ABSTRACT Objectives: 1) Explore the variability in how symptoms clustered together over the late reproductive stage, early and late meyesausal transition (MT) stages, and early postmenopause. 2) Determine if the symptom factor structure of the preceding MT stage would predict the symptom factor structure of the MT stage immediately following ...
De Smet Sarah - - 2012
Abstract Pigs are important reservoirs for Arcobacter. Since 1978, Arcobacter species have been associated with reproduction disorders, but excretion by clinically healthy pigs has been frequently reported as well. Information on Arcobacter colonization of the porcine gastrointestinal tract is lacking. In the present study, gastrointestinal tracts of 12 pigs were ...
O'Neill S M - - 2012
Objective Arterial stiffness is an independent marker of cardiovascular risk that increases with age, hypertension, diabetes and hyperlipidemia, both for men and women (although more pronounced in women). This study was designed to establish whether menopause augments the age-dependent change. Methods The study evaluated pulse wave analysis and pulse wave ...
Fineberg Harvey V - - 2012
Public health aims to provide the necessary conditions for a population to be healthy.(1,2) Public health balances such lofty ideals as health, happiness, and productivity with pragmatic problem solving-metaphorically, keeping its head in the clouds and its feet on the ground. Public health attempts to see health problems in their ...
Krantz Mori J - - 2012
Objectives. We evaluated whether a program to prevent coronary heart disease (CHD) with community health workers (CHWs) would improve CHD risk in public health and health care settings. Methods. The CHWs provided point-of-service screening, education, and care coordination to residents in 34 primarily rural Colorado counties. The CHWs utilized motivational ...
Chen Yongfei - - 2012
To investigate the antihypertensive effects and tolerability of aliskiren in comparison with other antihypertensive drugs and placebo in patients with hypertension, a meta-analysis was performed of studies published between 1950 and 2012. A systematic literature search of MEDLINE and the Cochrane Library was conducted for randomized controlled trials. Weighted mean ...
Santoro Marta - - 2012
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear hormone receptor expressed predominantly in adipose tissue, and it is implicated in energy homeostasis. In this study, by Western blotting and Immunofluorescence techniques, we demonstrated for the first time that pig spermatozoa express the PPARγ. To investigate the functional role of PPARγ ...
McQuiston Jennifer H - - 2012
Abstract Several spotted fever group rickettsiae (SFGR) previously believed to be nonpathogenic are speculated to contribute to infections commonly misdiagnosed as Rocky Mountain spotted fever (RMSF) in the United States, but confirmation is difficult in cases with mild or absent systemic symptoms. We report an afebrile rash illness occurring in ...
Sendker Jandirk - - 2012
The rational use of hawthorn leafs and flowers from Crataegus spp. for declining cardiac performance is mainly due to flavon-C-glycosides and oligomeric procyanidins (OPC). From OPC-enriched extracts from different batches, a dimeric phenylpropanoid-substituted procyanidin (cinchonain II b, 1) was isolated and characterized by MS, CD, and NMR. Also the presence of ...
Liu Xiuxia - - 2012
PtdIns synthase is a key enzyme in the phospholipid pathway and catalyses the formation of PtdIns. PtdIns is not only a structural component of cell membranes, but also the precursor of the phospholipid signal molecules which regulate plant response to environment stresses. Here, we obtained transgenic maize constitutively overexpressing or ...
Mihret Adane - - 2012
The immune response against Mycobacterium tuberculosis is multifactorial, involving a network of innate and adaptive immune responses. Characterization of the immune response, a clear understanding of the dynamics and interplay of different arms of the immune response are critical to allow the development of better tools for combating tuberculosis. Dendritic ...
Bona Gianni - - 2012
Background: Subclinical hypothyroidism (SH) is a quite common disorder in the pediatric age group. Objective: The aim of this paper is to present a review of the studies investigating the natural course of SH and the effects of replacement therapy with levothyroxine in childhood. Methods: We systematically searched PubMed, Cochrane, ...
Wu Yingjie - - 2012
We demonstrate the first example of a self-propelled Janus polyelectrolyte multilayer hollow capsule that can serve as both autonomous motor and smart cargo. This new autonomous Janus capsule motor composing of partially coated dendritic platinum nanoparticles (Pt NPs) was fabricated by using a template-assisted layer-by-layer (LbL) self assembly combined with ...
Zhao Meng-Qiang - - 2012
The theoretically proposed graphene/single-walled carbon nanotube (G/SWCNT) hybrids by placing SWCNTs among graphene planes through covalent C-C bonding are expected to be with extraordinary physical properties and promising engineering applications. However, the G/CNT hybrids that have been fabricated differ a lot with the proposed G/SWCNT hybrids either because the covalent ...
Thorne Leigh - - 2012
ABSTRACT: BACKGROUND: Protein misfolding cyclic amplification (PMCA) is a method that facilitates the detection of prions from many sources of transmissible spongiform encephalopathy (TSE). Sheep scrapie represents a unique diversity of prion disease agents in a range of susceptible PRNP genotypes. In this study PMCA was assessed on a range ...
Wang Z - - 2012
The purpose of this study was to determine EriB in plasma by using the method of HPLC and collect the preclinical pharmacokinetic parameters of EriB.The analysis involved a simple liquid-liquid extraction. After making alkaline with NaOH, plasma was extracted with diethyl ether and the organic extract was then evaporated. From ...
Verma Yogesh Kumar - - 2012
B Cell Lymphoma-2 (Bcl-2) protein suppresses ionizing radiation-induced apoptosis in hemato-lymphoid system. To enhance the survival of irradiated cells, we have compared the effects and mechanism of Bcl-2 and its functional variants, D34A (caspase-3 resistant) and S70E (mimics phosphorylation on S70). Bcl-2 and its mutants were transfected into hematopoietic cell ...
Sha Jing-Quan - - 2012
To investigate the influence of a secondary spacer on the resulting structures of POMOFs containing pytz, five new compounds with different dimensionalities, [Cu(5)(2-pytz)(6)(H(2)O)(4)][SiMo(12)O(40)]·3H(2)O (), [Cu(3)(2-pytz)(4)bipy][H(2)SiMo(12)O(40)]·bipy (), [Cu(3)(2-pytz)(2)(bipy)(4)(H(2)O)(6)][H(4)SiW(12)O(40)](2)·6H(2)O (), [Cu(2)(2-pytz)(phen)(OH)](2)[SiW(12)O(40)]·H(2)O (), [Cu(3)(4-pytz)(4)(H(2)O)(4)][H(2)SiW(12)O(40)]·2H(2)O (), were synthesized. When only 2-pytz was employed, compound with a 3D framework was obtained, whereas when the secondary ...
Gowda Charitha - - 2012
We thank Dodge for highlighting the potential environmental factors that may impact food insecurity upstream of the mechanistic pathway between food insecurity and health. Our work demonstrated that food insecurity is associated with C-reactive protein, a marker of inflammation associated with chronic health conditions such as diabetes, hyperlipidemia, and cardiovascular ...
Nafees Asaad Ahmed - - 2012
OBJECTIVES: To determine pattern and predictors for respiratory illnesses and symptoms and lung function among textile workers in Karachi, Pakistan. METHODS: This was a cross-sectional survey of 372 adult male textile workers from the spinning and weaving sections of 15 textile mills from Karachi. Data were collected from November to ...
Melillo Paolo - - 2012
ABSTRACT: BACKGROUND: We evaluated the association between linear standard Heart Rate Variability (HRV) measures and vascular, renal and cardiac target organ damage (TOD). METHODS: A retrospective analysis was performed including 200 patients registered in the Regione Campania network (aged 62.4 +/- 12, male 64%). HRV analysis was performed by 24-h ...
Soh Siowling - - 2012
The contact electrification of insulating organic polymers is still incompletely understood, in part because multiple fundamental mechanisms may contribute to the movement of charge. This study describes a mechanism previously unreported in the context of contact electrification: that is, "contact de-electrification", a process in which polymers charged to the same ...
Karimi Mohammad Yahya - - 2012
We assessed the association of functional single nucleotide polymorphisms (SNP) in FAS -1377, -670 and FAS ligand (FASL) -844 promoters in 139 oral cancer patients and 126 normal subjects by PCR-RFLP. In logistic regression analysis FAS -1377 GA genotype appeared to marginally increase the risk while FASL -844 TC genotype ...
Felton Luke - - 2012
Abstract The present study aimed to explore the mediating role of social factors on the associations between attachment styles and basic psychological needs satisfaction within two relational contexts. Athletes (N = 215) completed a multi-section questionnaire pertaining to attachment styles, basic needs satisfied within the coaching and the parental relational ...
Cusato Sueli - - 2012
Abstract The present study describes the implementation of a food safety system in a dairy processing plant located in the State of São Paulo, Brazil, and the challenges found during the process. In addition, microbiological indicators have been used to assess system's implementation performance. The steps involved in the implementation ...
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