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Results 351 - 400 of 2118
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Böhlen T T - - 2012
Uncertainties in determining clinically used relative biological effectiveness (RBE) values for ion beam therapy carry the risk of absolute and relative misestimations of RBE-weighted doses for clinical scenarios. This study assesses the consequences of hypothetical misestimations of input parameters to the RBE modelling for carbon ion treatment plans by a ...
Kim N-Y - - 2012
Mercury (Hg) is widely distributed in the environment and oral exposure is a main route in the general population. In this study, we estimated the dietary intake of Hg and its relationship with blood Hg levels in Korean adults. The study subjects were recruited from three different districts (rural: 189, ...
Savard Sébastien - - 2012
BACKGROUND: Initially based on histology, the diagnosis of renal artery fibromuscular dysplasia (FMD) is now mostly based on angiographic appearance because arterial tissue samples are rarely available. This retrospective cross-sectional study aimed to assess clinical relevance of a binary angiographic classification of FMD lesions (unifocal or multifocal) based on computed ...
Rose Martin H - - 2012
We investigated lower-extremity isometric tremor Approximate Entropy (irregularity), torque steadiness and rate of force development (RFD) and their associations to muscle activation strategy during isometric knee extensions in patients with Parkinson's disease (PD). Thirteen male patients with idiopathic PD and 15 neurologically healthy matched controls performed isometric maximal contractions (extension/flexion) ...
Divelbiss Daniel - - 2012
In rural health development practice, engineers and scientists must recognize the complex interactions that influence individuals' contact with disease-causing pathogens and understand how household habits may impact the adoption and long term sustainability of new technology. The goal of this study was to measure the effect of various environmental health ...
Zeeuwen Patrick L J M - - 2012
ABSTRACT: BACKGROUND: Recent advances in sequencing technologies have enabled metagenomic analyses of many human body sites. Several studies have catalogued the composition of bacterial communities of the surface of human skin, mostly under static conditions in healthy volunteers. Skin injury will disturb the cutaneous homeostasis of the host tissue and ...
Aydin S - - 2012
Sepsis, often initiated by an infection, is a state of disrupted inflammatory homeostasis. There is increasing evidence that oxidative stress has an important role in the development of sepsis-induced multiorgan failure. Resveratrol (RV) is a polyphenolic compound found in the skin of red fruits, such as mulberries and red grapes, ...
Corrias Andrea - - 2012
Thyroid nodules are less frequent in childhood than in adulthood, but are more often malignant. Recent estimates suggest that up to 25% of thyroid nodules in children are malignant, therefore, a more aggressive approach is recommended. In this review, we suggest an approach based on a first-step clinical, laboratory, and ...
Sbrana Francesco - - 2012
A carbapenem-sparing regimen of tigecycline plus gentamicin or colistin was effective for treating 24/26 (92%) KPC-Kp infectious episodes in 22 polytrauma ICU patients without comorbidities. The 30-day crude mortality rate was 14%. Regimens were considered appropriate in 12% of episodes according to Vitek® 2 and in 100% based on E-test.
Baumann Patric - - 2012
Various domains present the challenges of responding to stimuli in a specific manner, with the desired sensitivity or functionality, and only when required. Stimuli-responsive systems that are appropriately designed can effectively meet these challenges. Here, we introduce nanoreactors that encapsulate photosensitizer-protein conjugates in polymer vesicles as a source of "on ...
Phan Nguyen - - 2012
Plant cells use sugars mainly as a source or store of energy and cytoskeletons for anabolic reactions and for osmotic regulation. The perception of sugars and their responses are rather complex including the heterotrimeric G protein pathway and a seven-transmembrane RGS molecule. Previously, we found that endocytosis of the 7TM-RGS ...
Smith Nicola C - - 2012
Abstract It is unclear whether small animals with their high stride frequency and crouched posture or large animals with more tendinous limbs are more reliant on storage and return of elastic energy during locomotion. The ostrich has a limb structure that appears to be adapted for high speed running with ...
Sauer Désirée C - - 2012
The synthesis of a new family of chiral tridentate monoanionic NNN-pincer ligands based on the 1,3-bis(2-pyridylimino)isoindoline (BPI) framework is reported. Ligands with substituents of varying steric demand were prepared starting from achiral and low priced materials. A kinetic enzymatic resolution was used as a key step for the preparation of ...
Han Qing-Hua - - 2012
Lygodipenoids A (1) and B (2), two novel C33 tetracyclic triterpenoids with a new 9,19 : 24,32-dicyclopropane skeleton, were isolated from the whole grass of Lygodium japonicum. Their structures were elucidated by spectroscopic and chemical means. Compounds 1 and 2 were tested in transfected cultured human embryonic kidney 293 HEK293 cells for ...
Oguz K K - - 2012
BACKGROUND AND PURPOSE:Studies shows ictal behavior and symptoms are affected by patient sex in temporal lobe epilepsy. The purpose of our study was to determine whether alterations in the WM as assessed by DTI display different patterns in male and female patients with unilateral HS.MATERIALS AND METHODS:Patients with unilateral HS ...
Selvakumar K - - 2012
Polychlorinated biphenyls (PCBs) comprise a ubiquitous class of toxic substances associated with carcinogenic and tumor-promoting effects as well as neurotoxic properties. Reactive oxygen species, which is produced from PCBs, alters blood-brain barrier (BBB) integrity, which is paralleled by cytoskeletal rearrangements and redistribution and disappearance of tight junction proteins (TJPs) like ...
Thomas Kristen E - - 2012
The integration of vestibular and somatosensory information for the control of lower limb musculature remains elusive. To determine whether a subthreshold vestibular input influences the cutaneous evoked response, the isometric EMG activity in the posturally inactive soleus muscles of 13 healthy, seated subjects was collected. Vestibular afferents were activated using ...
Pagano Giovanni - - 2012
Abstract An involvement of oxidative stress (OS) was found in recent studies of Sjøgren's syndrome (SS) that reported significant changes in protein oxidation, myeloperoxidase activity, TNF-α, nitrotyrosine and GSH levels in plasma from SS patients. Excess levels of OS markers, as oxidative DNA damage and propanoyl-lysine were reported in saliva ...
Ravindran V - - 2012
Monozygotic twins, 27 years old, with primary anti-phospholipid syndrome have been described. The first of the twins had obstetric morbidities (one miscarriage at 12 weeks and premature birth of a growth-restricted fetus at 27 weeks secondary to pre-eclampsia) and the second had venous thrombosis. Lupus anticoagulant was present in both ...
Kilmer Beau - - 2012
Objectives. We examined the public health impact of South Dakota's 24/7 Sobriety Project, an innovative program requiring individuals arrested for or convicted of alcohol-involved offenses to submit to breathalyzer tests twice per day or wear a continuous alcohol monitoring bracelet. Those testing positive are subject to swift, certain, and modest ...
Yanagi Mai - - 2012
Accumulated evidence suggests that an altered ambulatory blood pressure (BP) profile, particularly elevated nighttime BP, reflects target organ injury and is a better predictor of further cardiorenal risk than the clinic BP or daytime BP in hypertensive patients complicated by chronic kidney disease (CKD). In this study, we examined the ...
Baxley Allison A - - 2012
Brentuximab vendotin is a monoclonal antibody approved in August 2011 for use in patients with Hodgkin disease and a rare systemic lymphoma known as anaplastic large cell lymphoma. Brentuximab is approved in patients with Hodgkin disease who have failed autologous transplantation or after failure of at least two prior multi-agent ...
Park Kwang-Yeol - - 2012
Background/Aims: An increase in the pulsatility index (PI) has been suggested to reflect distal vascular resistance. The purpose of the present study was to investigate the association between intracranial arterial calcification and intracranial PIs. Methods: Consecutive patients with acute ischemic stroke or transient ischemic attack were included. The PIs of ...
Edwards Arden Fredeking - - 2012
BACKGROUND: Although ablative laser technology and surgical treatment are considered to be the criterion standard for the rejuvenation of aging skin, the demand for procedures with less down time and risk, such as nonablative laser and radiofrequency (RF) treatments, has increased over the last several decades. OBJECTIVES: To investigate the ...
Si Jiyeon - - 2012
Norovirus (NoV) and hepatitis A virus (HAV) are pathogenic enteric viruses responsible for public health concerns worldwide. The viral transmission occurs through fecally contaminated food, water, fomites, or direct contact. However, the difficulty in cultivating these viruses makes it challenge to characterize the resistance to various environmental stresses. In this ...
Rouxel Mélanie - - 2012
Assortative mating resulting from host plant specialization has been proposed to facilitate rapid ecological divergence in biotrophic plant pathogens. Downy mildews, a major group of biotrophic oomycetes, are prime candidates for testing speciation by host plant specialization. Here, we combined a phylogenetic and morphological approach with cross-pathogenicity tests to investigate ...
Boers Maarten - - 2012
BACKGROUND/OBJECTIVE: Treatment of rheumatoid arthritis (RA) with tumour necrosis factor (TNF) antagonists changes the relationship between disease activity and progression of radiological joint damage ('disconnect'): patients who have little or no response of disease activity still show reductions in damage progression. In early RA, the COBRA strategy (combination of methotrexate ...
Grossman Daniel A - - 2012
Objectives. We assessed the effect of a telemedicine model providing medical abortion on service delivery in a clinic system in Iowa. Methods. We reviewed Iowa vital statistic data and billing data from the clinic system for all abortion encounters during the 2 years prior to and after the introduction of ...
Burrows Malcolm - - 2012
The kinematics and jumping performance of treehoppers (Hemiptera, Auchenorrhyncha, Membracidae) were analysed from high speed images. The 8 species analysed had an 11 fold range of body mass (3.8 mg to 41 mg) and a 2 fold range of body lengths (4.1 to 8.4 mm). Body shape was dominated by ...
Ozkaya Abdullah - - 2012
Abstract Purpose: To compare the effects of straight, oblique, and double-plane tunnel scleral intravitreal injection techniques, on short-term intraocular pressure (IOP) changes, occurrence of vitreous reflux (VR), and/or other complications. Methods: A total of 105 patients were included in this prospective study. Patients were assigned randomly to one of the ...
Brewer Philip B - - 2012
With the discovery of strigolactones as root exudate signals that trigger parasitic weed seed germination, and then as a branching inhibitor and plant hormone, the next phase of strigolactone research has quickly revealed this hormone class as a major player in optimizing plant growth and development. From the early stages ...
Szilágyi Melinda - - 2012
Carbon starvation is a common stress both in the Nature and in the industry. Carbon starvation stress response (CSSR) involves the regulation of several important processes including programmed cell death and reproduction of fungi, secondary metabolit production and extracellular hydrolase formation. To gain insight into the physiological events of CSSR ...
Martins Thomas B - - 2012
Patients with therapy-induced neutralizing antibodies (NAbs) to interferon-beta (IFN-β) have reduced responses to IFN-β treatment, resulting in higher relapse rates, increased magnetic resonance imaging activity, and a higher risk of disease progression. A functional assay was employed for both screening and titering of IFN-β NAbs utilizing a human cell line ...
Born M - - 2012
Purpose: To compare the dose area products of pediatric VCUG in daily practice with the dramatically reduced official German diagnostic reference levels, which are based on selected data. Materials and Methods: 413 consecutive pediatric VCUG examinations were analyzed. Results: The mean dose area product of all examinations was 0.97 dGycm². ...
Chew Ng Rilene A - - 2012
Objectives. We examined primary and secondary syphilis cases among men who have sex with men (MSM) in California, and the association of methamphetamine use and Internet use to meet sex partners (Internet use) with number of sex partners. Methods. We analyzed California surveillance data for MSM who were diagnosed with ...
Said Somiraa S - - 2012
Therapeutic angiogenesis is a new revascularization strategy involving the administration of growth factors to induce new vessel formation. The biology and delivery of angiogenic growth factors involved in vessel formation have been extensively studied but success in translating the angiogenic capacity of growth factors into benefits for vascular disease patients ...
Wang Bijun - - 2012
Perovskite-type oxide LaNiO(3) nanofibers (LNFs) have been successfully synthesized by electrospinning and sequential calcinations. The electrospun LNFs modified carbon paste electrode was used to construct a nonenzymatic hydrogen peroxide (H(2)O(2)) sensor and glucose biosensor for the first time. The LNFs composition was verified by X-ray diffraction, and the morphologies were ...
Waiswa Peter - - 2012
ABSTRACT: BACKGROUND: Reducing neonatal-related deaths is one of the major bottlenecks to achieving Millennium Development Goal 4. Studies in Asia and South America have shown that neonatal mortality can be reduced through community-based interventions, but these have not been adapted to scalable intervention packages for sub-Saharan Africa where the culture, ...
Seidman Gwendolyn - - 2012
Abstract The current study examined viewers' gaze while observing Facebook profiles of strangers varying in gender and physical attractiveness. Fifty-one participants viewed four Facebook profiles, a physically attractive and unattractive individual of each gender. Participants' eye movements were tracked as they viewed each profile for 60 seconds. Results showed that ...
Ambade Vipul Namdeorao - - 2012
The cause and manner of death in submersion cases are a routine challenge for forensic pathologists as they present considerable diagnostic difficulties. The present study was undertaken with a view to determine the characteristic pattern in bodies retrieved from water. From a total of 6779 medicolegal deaths reported at an ...
Uchea Chibuzor - - 2012
1. In vitro screens are sought as informative, alternatives to the use of animals in vivo and to improve upon the current use of fish liver 9000 g supernatants (S9) in environmental risk assessment. 2. The rates of ethoxyresorufin-O-deethylation (relative to S9 protein) measured under different conditions of culture of rainbow trout hepatocytes ...
Kim Kitae - - 2012
Manganese is one of the common elements in the earth crust and an essential micronutrient for all living things. The reductive dissolution of particulate manganese oxide is a dominant process to enhance mobility and bioavailability of manganese for the use of living organisms. In this work, we investigated the reductive ...
Barceló Antonia - - 2012
Background: Vitamin D insufficiency and high levels of parathyroid hormone (PTH) appear to be emerging risk factors for metabolic syndrome (MS), diabetes and cardiovascular disease, conditions that occur frequently in patients with obstructive sleep apnea syndrome (OSAS). Objectives: This study examined whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] and PTH ...
Yang Heejung - - 2012
Bioassay-guided fractionation of an 80 % methanolic extract of Salix pseudo-lasiogyne twigs has resulted in the isolation of two new compounds (1-2) along with ten known ones (3-12). The new compounds were determined to be 3'-O-acetylsalicin (1) and 2',6'-O-acetylsalicortin (2) by using spectroscopic analyses. Compounds (3-12) were identified as salicin (3), ...
Yang Yanmei - - 2012
The most notable role of small interfering RNA (siRNA) is in RNA interference (RNAi) and post-transcriptional gene silencing, which leads to a surge of interest in RNAi for both biomedical research and therapeutic applications. However, "naked" siRNA cannot cross cellular membranes freely because of highly negative charges which limits its ...
Naik Ravi - - 2012
A series of (E)-phenoxyacrylic amide derivatives were synthesized and evaluated as hypoxia inducible factor (HIF) 1α inhibitors. The present structure-activity relationship study on this series identified the morpholinoethyl containing ester 4p as a potent inhibitor of HIF-1α under hypoxic conditions (IC(50) = 0.12 μM in a cell-based HRE reporter assay) ...
Jardel Nicolas - - 2012
OBJECTIVE: To report a surgical technique and long-term outcomes of type II atresia ani (AA) and rectovaginal fistula (RvF) correction, using a fistula flap technique in kittens. STUDY DESIGN: Clinical study. ANIMALS: Domestic shorthaired female kittens (n = 6) with type II AA-RvF. METHODS: Diagnosis of type II AA-RvF was ...
Shin Seung-Heon - - 2012
Bee venom (BV) has long been used as an oriental traditional medicine for the control of pain and inflammation. However, BV's anti-inflammatory mechanisms remain unclear. This study aimed to clarify the potential clinical efficacy of BV concerning the anti-inflammatory effect on nasal epithelial cell inflammation. Nasal polyp epithelial cells were ...
Wang Xin - - 2012
Hypertension control rates are unacceptably low in China. The present study demonstrates if a customized, guideline-oriented training program can cost-effectively improve hypertension management in primary healthcare. Four typical community health centers in Beijing were selected and randomized to intervention or control (one urban and one rural each). A sample of ...
Xu Xian-Rong - - 2012
Aim: The purpose of this study was to determine the effects of lutein supplement on serum cytokines, apoE and lipoprotein profiles in early atherosclerosis population.Methods: Early atherosclerosis patients (n= 65) were randomized to receive placebo (A+P, n= 31) or 20 mg/d lutein (A+L, n= 34) for 3 months.Results: Serum lutein ...
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