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Moisseiev E E Department of Ophthalmology, Tel Aviv Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. - - 2013
To evaluate the long-term visual prognosis and complications of patients who received intravitreal Ozurdex injections for the treatment of macular edema (ME) due to retinal vein occlusion (RVO). A total of 17 patients who received Ozurdex injections in our institution as part of the GENEVA study were recalled for examination. ...
Rosenberg Helene F HF Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. - - 2013
Eosinophils have been traditionally perceived as terminally differentiated cytotoxic effector cells. Recent studies have profoundly altered this simplistic view of eosinophils and their function. New insights into the molecular pathways that control the development, trafficking and degranulation of eosinophils have improved our understanding of the immunomodulatory functions of these cells ...
Zang Shaoyun S Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida 33136, - - 2013
Active zones are specialized presynaptic structures critical for neurotransmission. We show that a neuronal maintenance factor, nicotinamide mononucleotide adenylyltransferase (NMNAT), is required for maintaining active zone structural integrity in Drosophila by interacting with the active zone protein, Bruchpilot (BRP), and shielding it from activity-induced ubiquitin-proteasome-mediated degradation. NMNAT localizes to the ...
de Moura L R LR Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Quebec, - - 2013
Our aim was to evaluate the potential effect of imatinib mesylate (IM), a small molecule that specifically inhibits the tyrosine quinase receptors, on the proliferation and invasive abilities of two human retinoblastoma (Rb) cell lines. Furthermore, the ability of IM to radiosensitize Rb cells was evaluated. The potential targets of ...
Schlesinger Sharon S Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, - - 2013
Embryonic stem cells repress retroviral infection through transcriptional silencing of proviral DNAs. We characterized two distinct mechanisms of silencing in embryonic mouse cells infected by Moloney murine leukaemia virus (MLV): a highly efficient one targeting the proline transfer RNA primer-binding site (PBSpro), and a less efficient one operating independently of ...
Oppelt Angela A Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, - - 2013
Although phosphatidylinositol 5-phosphate (PtdIns5P) is present in many cell types and its biogenesis is increased by diverse stimuli, its precise cellular function remains elusive. Here we show that PtdIns5P levels increase when cells are stimulated to move and we find PtdIns5P to promote cell migration in tissue culture and in ...
Keithley Richard B RB Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, - - 2013
A capillary electrophoresis system with an ultrasensitive three-color laser-induced fluorescence detector was constructed for the simultaneous measurement of glycosphingolipids conjugated with a family of BODIPY fluorophores. The compounds were separated by capillary electrophoresis and detected by laser-induced fluorescence excited within a sheath-flow cuvette. Diode-pumped solid-state lasers operating at 473 nm ...
Eagle R C RC Jr Department of Pathology, Wills Eye Institute, Philadelphia, PA 19107, USA. - - 2013
Primary cancers of the eye are rare. These include uveal melanoma, a tumor that preferentially affects the choroid of light-eyed, fair-skinned Europeans, and the pediatric retinal neoplasm retinoblastoma, which is slightly more common worldwide. Uveal melanoma kills about half of affected patients. Most succumb to hepatic metastases, which are unresponsive ...
Seregard S S Department of Vitreoretinal Diseases, St Eriks Eye Hospital and Karolinska Institutet, Stockholm, Sweden. - - 2013
Most intraocular tumours are reliably diagnosed by a careful clinical examination combined with one or more non-invasive diagnostic techniques. However, in a small percentage of tumours, typically small and clinically amelanotic, the features are insufficiently distinct for a confident clinical diagnosis and tissue is required for diagnosis. We used a ...
Liu S S CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, - - 2013
Activating and inhibitory receptors control natural killer (NK) cell activity. T-cell immunoglobulin and ITIM (immunoreceptor tyrosine-based inhibition motif) domain (TIGIT) was recently identified as a new inhibitory receptor on T and NK cells that suppressed their effector functions. TIGIT harbors the immunoreceptor tail tyrosine (ITT)-like and ITIM motifs in its ...
Toot Sandeep S Department of Mental Health Sciences, University College London, London, UK. - - 2013
The aims of this study were to identify which factors may lead to crisis for people with dementia and their carers and identify interventions these individuals believe could help in crisis. Qualitative study using focus groups to compare the perspectives of people with dementia, family carers and healthcare professionals on ...
Yuan Z Z Department of Surgery, Albert Einstein College of Medicine, Bronx, NY 10467, - - 2013
In the current study, we examined whether the combination of tumor vasculature-targeted gene therapy with adeno-associated virus bacteriophage-tumor necrosis factor-α (AAVP-TNF-α) and/or the orally administered LCL161, an antagonist of inhibitors of apoptosis proteins (IAPs), enhanced antitumor efficacy without systemic toxicity. M21 human melanoma xenografts were grown subcutaneously in nude mice. ...
Schrems-Hoesl L M LM Department of Ophthalmology, Cornea Service and Ocular Surface Imaging Center, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, - - 2013
To analyze the morphology and density of corneal epithelial cells, keratocytes, and subbasal nerves, in patients with early stage Fuchs' endothelial corneal dystrophy (FECD) by in vivo confocal microscopy (IVCM). IVCM (Confoscan 4, Nidek, Inc.) of the central cornea was performed in 30 corneas of 30 patients with early stage ...
Said Jonathan W JW Department of Pathology, David Geffen School of Medicine, University of California-Los Angeles, CA 90095, USA. - - 2013
Aggressive B-cell lymphomas are diverse group of neoplasms that arise at different stages of B-cell development and by various mechanisms of neoplastic transformation. The aggressive B-cell lymphomas include many types, subtypes and variants of diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), mantle cell lymphoma and its blastoid variant, and ...
Hampton Lyla E LE Department of Psychology, University of Houston, Houston, TX, USA. - - 2013
We compared neuropsychological profiles in children with shunted hydrocephalus secondary to aqueductal stenosis (AS), a rare form of congenital hydrocephalus, and spina bifida myelomeningocele (SBM), a common form of congenital hydrocephalus. Participants were 180 children with shunted hydrocephalus grouped according to etiology: SBM (n = 151), AS (n = 29), ...
Ghosh Supratim S a Department of Cancer Biology , Wake Forest School of Medicine , Winston-Salem , NC , USA - - 2013
The simultaneous binding of netropsin in the minor groove and Zn(2+) in the major groove of a DNA hairpin that includes 10 consecutive FdU nucleotides at the 3'-terminus (3'FdU) was demonstrated based upon NMR spectroscopy, circular dichroism (CD), and computational modeling studies. The resulting Zn(2+)/netropsin: 3'FdU complex had very high ...
Phillips Charles D - - 2012
Objectives. We explored differences in criminal convictions between holders and nonholders of a concealed handgun license (CHL) in Texas. Methods. The Texas Department of Public Safety (DPS) provides annual data on criminal convictions of holders and nonholders of CHLs. We used 2001 to 2009 DPS data to investigate the differences ...
Allen Sharon S - - 2012
INTRODUCTION: Accumulating evidence has linked depressive symptoms and sex hormones to risk for relapse; however, the specific mechanisms involved in these associations remain unknown. This randomized crossover study assessed physiological response to nicotine by menstrual phase in female smokers with and without depressive symptoms following acute smoking abstinence. METHODS: Females, ...
Han Zhang - - 2012
ABSTRACT: BACKGROUND: It's unknown whether the prognostic value of admission heart rate (HR) was different in patients with ST-segment elevation myocardial infarction (STEMI) with or without concomitant type 2 diabetes mellitus (T2DM). METHODS: Consecutive STEMI patients who presented within 12 hours of symptom onset were recruited from 274 hospitals in ...
Havre R F - - 2012
Purpose: To investigate whether ultrasound-based strain imaging can discriminate between colorectal adenocarcinomas and stenotic Crohn's lesions in newly resected surgical specimens.Materials and Methods: Resected surgical specimens from 27 patients electively operated for colorectal tumors or stenotic lesions from Crohn's disease were prospectively examined with ultrasonography using a Hitachi HV 900 ...
Youngstrom Eric A - - 2012
Assessment has been a historical strength of psychology, with sophisticated traditions of measurement, psychometrics, and theoretical underpinnings. However, training, reimbursement, and utilization of psychological assessment have been eroded in many settings. Evidence-based medicine (EBM) offers a different perspective on evaluation that complements traditional strengths of psychological assessment. EBM ties assessment ...
Beel Benedikt - - 2012
Cryptochromes (CRYs) are flavoproteins that are known as blue light photoreceptors in many organisms. Recently, genome sequences from a variety of algae became available. Functional characterizations of animal-like CRYs from Oestreococcus tauri, Chlamydomonas reinhardtii and Phaeodactylum tricornutum highlighted novel functions and properties. As arising from studies in fungi, certain algal ...
Scalise F - - 2012
OBJECTIVES: Chronic cerebrospinal venous insufficiency (CCSVI) is a malformative condition characterized by several anomalies of the azygos and/or internal jugular veins (IJVs). Recommended diagnosis of CCSVI is performed with colour-Doppler (CD) sonography. Though catheter venography (CV) is considered as the gold standard for determining vascular anatomy, its uniplanar point of ...
Liu Bo - - 2012
PURPOSE: Muller glia respond to retinal injury by a reactive gliosis but only rarely do mammalian glial cells re-enter the cell cycle and generate new neurons. In the non-mammalian retina, however, Muller glia act as stem/progenitor cells. Here, we test the function of Wnt signaling in the post-injury retina, focusing ...
Reboud V - - 2012
We report on a method to enhance the light-emission efficiency of printable thin films of a polymer doped with luminescent (CdSe)ZnS nanocrystals via metallic nanoparticles and nanoimprinted photonic crystals. We experimentally show a strong fluorescence enhancement of nanocrystals by coupling exciton-plasmon with the localized surface plasmon of metallic nanoparticles. The ...
Uysal Ahmet - - 2012
Background/Aims: Thalassemia is one of the most common hereditary disorders in Turkey. The aim of our study was to determine the prevalence of the β-thalassemia trait and abnormal hemoglobin in couples who applied for premarital screening in the third largest Turkish province of Izmir in the Aegean region. Methods: From ...
Abdel-Latif M E - - 2012
OBJECTIVE: To compare neurodevelopmental outcomes of extremely preterm infants conceived after assisted conception (AC) compared with infants conceived spontaneously (non-AC). DESIGN: Population-based retrospective cohort study. SETTING: Geographically defined area in New South Wales and the Australian Capital Territory, Australia served by a network of 10 neonatal intensive care units. PATIENTS: ...
Ferraro Geraldo Argolo - - 2012
HIV-1 provirus activation is under control of the LTR-5´ viral promoter region, which presents remarkable genetic variation among HIV-1 subtypes. It is possible that molecular features of the LTR contribute to the unusual subtype C epidemic profile in Brazilian Southern region. In order to characterize the LTR of Brazilian HIV ...
Huang Shaobai - - 2012
The mitochondrial enzyme succinate dehydrogenase (SDH) consists of four subunits, a flavoprotein (SDH1), an iron-sulfur (Fe-S) protein (SDH2) and two integral membrane subunits (SDH3/SDH4). In mammals and yeast, an assembly factor termed SDHAF2/SDH5 is required for accumulation of flavinylated SDH1. In Arabidopsis, we have recently reported the characterization of an ...
Wu Jia - - 2012
This work presents a novel approach to analyze the function of the human right ventricle (RV) by deriving kinematic features of the relative change in shape throughout the cardiac cycle. The approach is anatomically consistent, allows direct comparison across populations of individuals, and potentially provides new metrics to improve the ...
Cook Jonathan L - - 2012
BACKGROUND: Large full-thickness wounds of the upper lip are often referred to operating room-based surgeons for repair given the perceived difficulties in restoring upper lip form and function with simpler operative techniques. OBJECTIVE: To illustrate the functional, aesthetic, and cost differences between two techniques used to repair full-thickness wounds of ...
Matvejev Vladimir - - 2012
Solvation in water requires minimizing the perturbations in its hydrogen bonded network. Hence solutes distort water molecular motions in a surrounding domain, forming a molecule-specific hydration shell. The properties of those hydration shells impact the structure and function of the solubilized molecules, both at the single molecule and at higher ...
Yanow Susan - - 2013
The Roe v Wade decision made safe abortion available but did not change the reality that more than 1 million women face an unwanted pregnancy every year. Forty years after Roe v Wade, the procedure is not accessible to many US women. The politics of abortion have led to a ...
Linke M - - 2012
Ovarian stimulation with gonadotrophins is an integral part of assisted reproductive technologies in human subfertility/infertility treatment. Recent findings have associated ovarian stimulation with the increased incidence of imprinting disorders in humans as well as defects in genome-wide methylation reprogramming and, in particular, imprinting in mice. Here, we present the first ...
Büyükgebiz Atilla - - 2012
Newborn screening (NS) for congenital hypothyroidism (CH) is one of the major achievements in preventive medicine. Most neonates born with CH have normal appearance and no detectable physical signs. Hypothyroidism in the newborn period is almost always overlooked, and delayed diagnosis leads to the most severe outcome of CH, mental ...
Lavín Carmen - - 2012
Theoretical cross sections for photoionization of the methanol valence orbitals in covering a region up to 80 eV beyond the first ionization potential are reported. The molecular quantum defect orbital, MQDO, method, which has proved to be reliable in previous applications to molecular photoionization, has been used. To our knowledge, ...
Kimmerle Joachim - - 2012
Abstract In computer-supported information exchange, people frequently tend to withhold their own information and free-ride on the others' contributions. In doing so, they save costs (time and effort) and maximize their own benefit. However, if everyone behaved in this way, there would be no information sharing at all. In this ...
Lanéelle Marie-Antoinette - - 2012
Mycolic acids, very long-chain α-alkyl, β-hydroxylated fatty acids, occur in the Corynebacteriales order where their chain lengths (C26 to C88) and structural features (oxygen functions, cis or trans double bonds, cyclopropane rings and methyl branches) are genus- and species-specific. The molecular composition and structures of the mycolic acids of two ...
Harley Stephen J - - 2012
The dynamic and equilibrium water vapor sorption properties of Sylgard-184, a commercially available poly(dimethylsiloxane) elastomer (PDMS), were determined via gravimetric analysis from 30 to 70 °C. Described here is a methodology for quantitatively assessing how water vapor diffuses and ad/absorbs into polymeric materials that are traditionally considered hydrophobic. PDMS materials ...
Chou Wen-Ying Sylvia - - 2012
As Web 2.0 and social media make the communication landscape increasingly participatory, empirical evidence is needed regarding their impact on and utility for health promotion. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched 4 medical and social science databases for literature (2004-present) on the intersection of ...
Bradford Natalie - - 2012
We conducted a pilot study to investigate the effectiveness of a home telehealth service for paediatric palliative care consultations. Over a 10 week period, 14 of the 17 caregivers approached to be part of the study agreed to participate. Families were allocated, non-randomly, to a control group (usual care) or ...
Sørensen Jesper G - - 2012
Ecological relevance and repeatability of results obtained in different laboratories are key issues when assessing thermal tolerance of ectotherms. Traditionally assays have used acute exposures to extreme temperatures. The outcomes of ecologically more relevant ramping experiments, however, are dependent on the rate of temperature change leading to uncertainty of the ...
Beck John J - - 2012
The spiroketal (E)-conophthorin has recently been reported as a semiochemical of the navel orangeworm moth, a major insect pest of California pistachios and almonds. Conophthorin and the isomeric spiroketal chalcogran are most commonly known as semiochemicals of several scolytid beetles. Conophthorin is both an insect- and plant-produced semiochemical widely recognized ...
Sanyal Udishnu - - 2012
A new solid state synthetic route has been developed toward metal and bimetallic alloy nanoparticles from metal salts employing amine-boranes as the reducing agent. During the reduction, amine-borane plays a dual role: acts as a reducing agent and reduces the metal salts to their elemental form and simultaneously generates a ...
Mitani Kaoru - - 2012
Sappanwood (Caesalpinia sappan Linn.) is used as an herbal medicine. It is sometimes used to treat skin damage or as a facial cleanser. In the present study, the methanol (MeOH) extract of sappanwood was found to inhibit melanin synthesis in cultured human melanoma HMV-II cells stimulated with forskolin, and six ...
Muhammad Sohail - - 2012
The displacement of a CO ligand from an unusually labile rhenium carbonyl complex containing a bidentate carboxyaldehyde pyrrolyl ligand by PPh(3) and pyridine has been investigated. The reaction is found to proceed by an associative, preequilibrium mechanism. Theoretical calculations support the experimental data and provide a complete energetic profile for ...
Telsemeyer Julia - - 2012
High dose gradients are inherent to ion beam therapy. This results in high sensitivity to discrepancies between planned and delivered dose distributions. Therefore an accurate knowledge of the ion stopping power of the traversed tissue is critical. One proposed method to ensure high quality dose deposition is to measure the ...
Yang Xin - - 2012
Nitrogenous disinfection byproducts (N-DBPs) such as haloacetonitriles (HANs) and halonitromethanes (HNMs) are formed during water chlorination. Preozonation is sometimes applied to control trihalomethane (THM) formation, but this may risk promoting the formation of HNMs and HANs. The role of ozone in the formation of HANs and HNMs in natural waters ...
Stegeman Gregory W - - 2012
Temperature-dependent behaviours in C. elegans, such as thermotaxis and isothermal tracking, are complex behavioral responses that integrate sensation, foraging and learning, and have driven investigations to discover many essential genetic and neural pathways. The ease of manipulation of the Caenorhabditis model system also has encouraged its application to comparative analyses ...
Claro Tania - - 2012
Staphylococcus aureus is the major pathogen of the genus staphylococci and the most common cause of bone infections. These infections are mainly characterized by bone destruction and inflammation and are often debilitating and very difficult to treat. Previously we demonstrated that S. aureus protein A (SpA) can bind to osteoblasts ...
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