Search Results
Results 201 - 250 of 2118
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Kang Kai - - 2012
This study investigated whether cytokine enhancement of a biodegradable patch could restore cardiac function after surgical ventricular restoration (SVR) even when seeded with cells from old donors. SVR can partially restore heart size and improve function late after an extensive anterior myocardial infarction. However, 2 limitations include the stiff synthetic ...
Hoefen Ryan - - 2012
The study was designed to assess the ability of computer-simulated electrocardiography parameters to predict clinical outcomes and to risk-stratify patients with long QT syndrome type 1 (LQT1). Although attempts have been made to correlate mutation-specific ion channel dysfunction with patient phenotype in long QT syndrome, these have been largely unsuccessful. ...
Flather Marcus - - 2012
This study sought to assess whether patient age modifies the comparative effectiveness of coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI). Increasingly, CABG and PCI are performed in older patients to treat multivessel disease, but their comparative effectiveness is uncertain. Individual data from 7,812 patients randomized in ...
Koc-Zorawska Ewa - - 2012
Background/Aims: VAP-1 (vascular adhesion protein-1) is a copper-containing SSAO (semicarbazide sensitive amine oxidase) secreted by vascular smooth muscle cells, adipocytes, endothelial cells with functional monoamine oxidase activity. The oxidation process generates harmful products that may be involved in atherosclerosis and vascular damage. Elevation of SSAO activity is observed in atherosclerosis, ...
Ohashi Yasushi - - 2012
Background/Aims: Obesity and hypervolemic status are the main causes of hypertension in patients with chronic kidney disease (CKD). However, it is difficult to differentiate between them. We aimed to assess the associations of body mass index (BMI) and total body water (TBW) with ambulatory blood pressure (ABP). Methods: Body composition ...
Lin Peng - - 2012
HUmic-Like substances (HULIS) in ambient aerosols collected at seven locations in East Asia were analyzed using electrospray ionization (ESI) coupled with an ultrahigh resolution mass spectrometer (UHRMS). Locations included a 3-km high mountaintop site in Taiwan, rural, suburban and urban locations in the Pearl River Delta (PRD), South China and ...
Robbins Timothy J - - 2012
Monovalent (Na(+)) and divalent (Mg(2+)) ion distributions around the Dickerson-Drew dodecamer were studied by atomistic molecular dynamics (MD) simulations with AMBER molecular modeling software. Different initial placements of ions were tried and the resulting effects on the ion distributions around DNA were investigated. For monovalent ions, results were found to ...
Tripathi J K - - 2012
Self-assembled α-FeSi(2) nanoislands were formed using solid-phase epitaxy of low (∼1.2 ML) and high (∼21 ML) Fe coverages onto vicinal Si(111) surfaces followed by thermal annealing. At a resulting low Fe-covered Si(111) surface, we observed in situ, by real-time scanning tunneling microscopy and surface electron diffraction, the entire sequence of Fe-silicide formation and ...
Inagaki Hideaki - - 2012
It is known that long-term post-weaning individual housing significantly reduces emissions of 22-kHz calls in male rats. In this study, we assessed post-weaning successive changes in 22-kHz calls emitted by male rats under two different types of post-weaning housing conditions (individually and socially). In addition, we evaluated the critical point ...
Kireeva N - - 2012
HERG potassium channels have a critical role in the normal electrical activity of the heart. The blockade of hERG channels in heart cells can result in a potentially fatal disorder called long QT syndrome. HERG channels can be blocked by compounds with diverse structures belonging to several drug classes. Presented ...
Feldborg Lise N - - 2012
We present here a highly efficient and chemoselective liposome functionalization method based on oxime bond formation between a hydroxylamine and an aldehyde modified lipid component. We have conducted a systematic and quantitative comparison of this new approach with other state-of-the-art conjugation reactions in the field. Targeted liposomes that recognize over-expressed ...
Mitra Gopa - - 2012
Glutathionyl hemoglobin, a posttranslationally modified form of hemoglobin, has been reported to serve as a marker of oxidative stress in several clinical conditions. This modification causes perturbations in the hemoglobin function by increasing oxygen affinity and reducing cooperativity. Moreover glutathionylation of sickle hemoglobin was reported to lead to a significant ...
Shafaei Mohammad R - - 2012
In situ deployments of diffusive gradients in thin films (DGT) can provide direct information on complex dissociation rates in natural waters. Recent advances in understanding the dynamics of the interactions of metal complexes within DGT devices have highlighted the characteristics of the binding layer, but there are few data to ...
Barvkar Vitthal T - - 2012
Flax (Linum usitatissimum L.) seeds are an important source of food and feed due to the presence of various health promoting compounds, making it a nutritionally and economically important plant. An in-depth analysis of the proteome of developing flax seed is expected to provide significant information with respect to the ...
Canevari Thiago C - - 2012
This paper describes the development, characterization and application of an Nb(2)O(5) film formed on the surface of a carbon ceramic material, SiO(2)/C, obtained by a sol-gel method, using the spin-coating technique. The working electrode using this material will be designated as SiCNb. Hydroquinone and catechol can be oxidized at this ...
Bhatnagar K - - 2012
We demonstrate strong electromagnetic field enhancement from nano-gaps embedded in silver gratings for visible wavelengths. These structures fabricated using a store-bought HD-DVD worth $10 and conventional micro-contact printing techniques have shown maximum fluorescence enhancement factors of up to 118 times when compared to a glass substrate under epi-fluorescent conditions. The ...
Hahn Elisabeth - - 2012
This article summarizes the status of three recent German twin studies: CoSMoS, SOEP, and ChronoS. The German twin study on Cognitive Ability, Self-Reported Motivation, and School Achievement (CoSMoS) is a three-wave longitudinal study of monozygotic and dizygotic twins reared together, and aims to investigate predictors of and influences on school ...
Erete Erete I - - 2012
ABSTRACT: BACKGROUND: There has been a paucity of autopsy studies on atherosclerotic lesions in Nigerians, the last one conducted at our centre being more than four decades ago. There has also been considerable epidemiological transition. The objective of the study was to determine the frequency, severity, pattern and distribution of ...
Courneya Kerry S - - 2012
ABSTRACT: BACKGROUND: Limited research has examined the association between physical activity, health-related fitness, and disease outcomes in breast cancer survivors. Here, we present the rationale and design of the Alberta Moving Beyond Breast Cancer (AMBER) Study, a prospective cohort study designed specifically to examine the role of physical activity and ...
Gach Philip C - - 2012
A microfabricated platform was developed for highly parallel and efficient colony picking, splitting and clone identification. A pallet array provided patterned cell colonies which mated to a second printing array composed of bridging microstructures formed by a supporting base and attached post. The posts enabled mammalian cells from colonies initially ...
Gadhe Changdev G - - 2012
Chemokine receptor 5 (CCR5) is an integral membrane protein that is utilized during human immunodeficiency virus type-1 entry into host cells. CCR5 is a G-protein coupled receptor that contains seven transmembrane (TM) helices. However, the crystal structure of CCR5 has not been reported. A homology model of CCR5 was developed ...
Hu Bo - - 2012
A hybrid bactericidal material, gold nanorod-covered kanamycin-loaded hollow SiO(2) (HSKAu(rod)) nanocapsules, is constructed. The hybrid material combines the features of a chemical drug with photothermal physical sterilization which decreases the dosage of broad-spectrum antibiotic and the physical damage of biological systems. Hollow SiO(2) nanocapsules are used as carriers for drug ...
Takeuchi Toshihide - - 2012
This feature article offers a comprehensive account of a decade of research devoted to the combination of the grand sensing principles with synthetic transport systems that act in lipid bilayers. Differential sensing, that is pattern generation and pattern recognition, is exemplified with an artificial nose. The aptamer version of immunosensing ...
Kimura Moritsugu - - 2012
Propylthiouracil (PTU) is recommended as a first-line antithyroid drug (ATD) during first trimester organogenesis in pregnancy because recent evidence suggests that methimazole (MMI) may be associated with congenital anomalies. However, PTU more commonly causes myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, which usually occurs during prolonged treatment, compared with MMI. We ...
Zhang Xiqi - - 2012
Water soluble and biocompatible fluorescent organic nanoparticles based on aggregation-induced emission (AIE) material were facilely prepared by mixing AIE material and surfactant. The utilization of such fluorescent organic nanoparticles for cell imaging applications was further explored.
Goldberg Frederick Woolf - - 2012
11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) has been a target of intensive research effort across the pharmaceutical industry, due to its potential for the treatment of type II diabetes and other elements of the metabolic syndrome. In order to demonstrate the value of 11β-HSD1 in pre-clinical models we required inhibitors with good ...
Lizzi Federica - - 2012
A combinatorial library of quinone-polyamine conjugates designed to optimize the anti-trypanosomatid profile of hit compounds 1 and 2 has been prepared by a solid phase approach. The conjugates were evaluated against three most important human trypanosomatid pathogens (T. b. rhodesiense, T. cruzi, and L. donovani) and several showed promising activity. ...
Avilés Félix L - - 2012
The transport properties of ultra-thin SrTiO(3) (STO) layers grown over YBa(2)Cu(3)O(7) electrodes were studied by conductive atomic force microscopy at the nano-scale. A very good control of the barrier thickness was achieved during the deposition process. A phenomenological approach was used to obtain critical parameters regarding the structural and electrical ...
Zavos Apostolos - - 2012
Various ovarian substances regulate the secretion of gonadotrophins during the menstrual cycle, but there are still several unclarified issues. The aim of this study was to investigate the positive feedback effect of progesterone during the immediate period following ovariectomy. Experiments were performed in 12 normally cycling women (aged 39-49 years). ...
Mashayekhi Vida - - 2012
Based on the existing reports regarding the antiplatelet aggregation activity of hydrazone derivatives, a series of indole hydrazone derivatives were considered as potential antiplatelet agents and synthesized. The structures of the synthesized compounds were confirmed by spectral data and elemental analysis. The new indole hydrazone derivatives were evaluated for their ...
Nweze Nwakaego E - - 2012
Context: The leaves of Irvingia gabonensis Baill. Ex Lanen (Irvingiaceae), Ficus exasperata Vahl (Moraceae), and Vernonia amygdalina Delile (Asteraceae) are folklorically used in treating worm infestation in Eastern Nigeria. The anthelmintic potential of the ethanol extracts of the leaves of I. gabonensis, F. exasperata, and V. amygdalina was investigated. Materials: ...
Achouri Djamila - - 2012
Amongst the various routes of drug delivery, the field of ocular drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical scientist. Recent research has focused on the characteristic advantages and limitations of the various drug delivery systems, and further research will be required before the ...
Chavarria Laia - - 2012
Liver transplantation (LT) candidates experience frequently episodic or persistent hepatic encephalopathy. In addition, these patients can exhibit neurological comorbidities that contribute to cognitive impairment in the pre-transplant period. Assessment of the respective contribution of hepatic encephalopathy or comorbidities in the cognitive manifestations is critical to estimate the neurological benefits of ...
Feng Jie - - 2012
The coalesce-induced condensate drop motion on some superhydrophobic surfaces (SHSs) has attracted increasing attention due to its wide potential applications. However, microscopic mechanism of spontaneous motion has not been discussed thoroughly. In this study, we fabricated two types of superhydrophobic copper surfaces with sisal-like nanoribbon structures and defoliation-like nanosheet structures ...
Bouzon Zenilda L - - 2012
We undertook a study of Porphyra acanthophora var. brasiliensis to determine its responses under ambient conditions, photosynthetically active radiation (PAR), and PAR+UVBR (ultraviolet radiation-B) treatment, focusing on changes in ultrastructure, and cytochemistry. Accordingly, control ambient samples were collected in the field, and two different treatments were performed in the laboratory. ...
Segal Nancy L - - 2012
A look at scientific studies of sports performance is informative in view of the 2012 Olympic games in London. The athletic life histories of selected twin competitors supplement the scientific data. Reviews of recent twin studies concerning cardiometabolic risk factors, postnatal brain maturation, parental responses to rearing triplets, and the ...
Liu Zhifu - - 2012
A novel plasma jet desorption atomization (PJDA) source was developed for atomic fluorescence spectrometry (AFS) and coupled on line with thin layer chromatography (TLC) for mercury speciation. A dielectric barrier discharge plasma jet, which is generated inside a 300-μm quartz capillary, interacts directly with the sample being analyzed, and is ...
Chen Rong - - 2012
Ovary benign clear cell adenofibroma (CCAF) is extremely rare. Here, we reported a 38-year-old woman with CCAF who was given sequential cyclic hormone replacement therapy for eight years due to premature ovarian failure (POF). At operation, we found adenofibromas in both ovaries and well encapsulated. The cut surface was cystic ...
Ray Saurabh - - 2012
Abstract Background: Patients treated with epidermal growth factor receptor inhibitors (EGFRIs) may develop dermatologic adverse drug reactions (ADRs) that may affect patients' quality of life, require medical care, and may lead to substantial costs. This study assessed the economic burden of dermatologic ADRs in colorectal cancer (CRC), head and neck ...
Rimondi Erika - - 2012
The effect of the multi-kinase inhibitor Sorafenib was investigated in an in vitro model of human osteoclastogenesis, represented by peripheral blood mononuclear cells (PBMCs) induced to differentiate into osteoclast-like cells in presence of receptor activator of nuclear factor kappa B ligand (RANKL) plus macrophage-colony stimulating factor (M-CSF). Sorafenib significantly inhibited ...
Brafman D A - - 2012
Many cellular responses during development are regulated by interactions between integrin receptors and extracellular matrix proteins (ECMPs). Although the majority of recent studies in human embryonic stem cell (hESC) differentiation have focused on the role of growth factors, such as FGF, TGFβ, and WNT, relatively little is known about the ...
Zhao Hui - - 2012
Background: Adaptive immunity plays a critical role in atherosclerosis and hypertension. T helper 17 (Th17) cells, as a new T-cell lineage, are involved in cardiovascular diseases. Dendritic cells (DCs) are the professional antigen-presenting cells with the pivotal role in orchestrating adaptive immunity. Thymic stromal lymphopoietin (TSLP) can activate DCs and ...
Hristozov Danail - - 2012
Abstract Hazard identification is an important step in assessing nanomaterial risk and is required under multiple regulatory frameworks in the US, Europe and worldwide. Given the emerging nature of the field and complexity of nanomaterials, multiple studies on even basic material properties often result in varying data pointing in different ...
Seyfferth Angelia - - 2012
Arsenic-contaminated rice grain may threaten human health globally. Since H<sub>3</sub>AsO<sub>3</sub><sup>0</sup> is the predominant As species found in paddy pore waters, and H<sub>3</sub>AsO<sub>3</sub><sup>0</sup> and H<sub>4</sub>SiO<sub>4</sub><sup>0</sup> share an uptake pathway, Si amendments have been proposed to decrease As uptake and consequent As concentrations in grains. Here, we evaluated the impact of two ...
Boltena Andualem Tadesse - - 2012
ABSTRACT: BACKGROUND: Meeting the medical and sexual health care needs of young people is crucial for sustainable development. In Uganda, youth are faced with a number of challenges related to accessing medical care and sexual health counselling services. This study sought to investigate the barriers faced by Ugandan university students ...
Playfoot David - - 2012
In spite of their unusual orthographic and phonological form, acronyms (e.g., BBC, HIV, NATO) can become familiar to the reader, and their meaning can be accessed well enough that they are understood. The factors in semantic access for acronym stimuli were assessed using a word association task. Two analyses examined ...
Johansson Ada - - 2012
The Genetics of Sexuality and Aggression (GSA) project was launched at the Abo Akademi University in Turku, Finland in 2005 and has so far undertaken two major population-based data collections involving twins and siblings of twins. To date, it consists of about 14,000 individuals (including 1,147 informative monozygotic twin pairs, ...
Sun Jingxu - - 2012
ABSTRACT: BACKGROUND: In this meta-analysis we aimed to determine the effectiveness and safety of hyperthermic intraperitoneal chemotherapy (HIPC) for patients with advanced gastric cancer who underwent gastrectomy. METHODS: In accordance with standard meta-analysis procedures, our study included patients who underwent resection for advanced gastric cancer and were randomly allocated to ...
Xiccato G - - 2012
During growth (from 27 to 75 days of age), 384 rabbits were kept in different types of wire-net cages: 72 individual cages (72 rabbits; 10 animals/m2), 48 bicellular cages (96 rabbits; 2 rabbits/cage; 18 animals/m2) and 24 collective cages (216 rabbits; 9 rabbits/cage; 18 animals/m2). The rabbits housed in individual ...
White Simon J - - 2012
Numerous nanoscale devices and materials have been fabricated in recent years using a variety of biological scaffolds. However, the interfacing of these devices and materials into existing circuits and ordered arrays has proved problematic. Here, we describe a simple solution to this problem using self-assembly of the peptide coiled-coil heterodimer ...
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