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Lee Jian-Jr - - 2012
ABSTRACT: Kasabach-Merritt phenomenon (KMP) is a rare and life-threatening disease of vascular tumor combined with severe consumptive coagulopathy. Currently, there is no established effective treatment of KMP. In this case series, from 2006 to 2008, we treated 6 pediatric patients with newly diagnosed KMP using intralesional corticosteroid injections. The severity ...
Kim Ae Ran - - 2012
: Little is known about how quality of life (QOL) changes over time after gastrectomy. We prospectively examined changes of QOL in Korean patients with gastric cancer after curative resection. : As early detection and improved treatment have led to higher survival rates and an increasing number of long-term survivors, ...
Teng Ann Y - - 2012
This article illustrates the impact of obstructive sleep apnea (OSA) on the work force and emphasizes that there are public health risks and significant societal financial losses in untreated OSA. Specifics of OSA impact on individuals are discussed with regard to veterans, first responders, farmers, and pilots, specially focusing on ...
Hsu Li-Ling - - 2012
: Nurses are experiencing new ethical issues because of global developments and changes in the healthcare environment. Blended learning is one of the various methods used to deliver meaningful learning experiences. Well-designed, properly administered nursing ethics education is essential for nursing students to visualize the role of professional nurses. However, ...
Lai Chung-Sheng - - 2012
ABSTRACT: There is a painting that looks like a representation of a simple surgical procedure. However, it holds a warm story of the love surrounding the first skin graft made by Dr. David Landsborough III for a Taiwanese child in 1928. He harvested the donor skin from his wife, Marjorie ...
Lobo Alice Z C - - 2012
The utility of sectioning at multiple levels in the histopathologic analysis of sentinel lymph nodes (SLNs) for melanoma and the correlation of metastasis size with risk of subsequent metastasis were investigated. Metastatic melanoma was identified in SLNs from 91 of 475 (19%) melanoma patients with SLN sampling at the Massachusetts ...
Diaz-Guzman Enrique - - 2012
Chronic obstructive pulmonary disease represents a major cause of morbidity and mortality in industrialized and nonindustrialized countries. Although tobacco use remains the main factor associated with development of the disease, occupational risk factors represent an important and preventable cause. The most common occupationally related factors include exposure to organic dusts, ...
O'Flaherty John D - - 2012
The cancer stem-cell (CSC) hypothesis suggests that there is a small subset of cancer cells that are responsible for tumor initiation and growth, possessing properties such as indefinite self-renewal, slow replication, intrinsic resistance to chemotherapy and radiotherapy, and an ability to give rise to differentiated progeny. Through the use of ...
Lee Yao-Chou - - 2012
ABSTRACT: Trismus is a common problem among oral cancer patients. This report aimed to study the inciting factors of trismus and to find out the rationale of trismus release. Between 1996 and 2008, 61 oral cancer patients with retrievable records of interincisor distance (IID) were analyzed by retrospective chart review. ...
Chang Kao-Ping - - 2012
MicroRNAs (miRs) are involved in gene expression and function, but little is known of their function in ischemia-reperfusion injury (IRI), which plays a critical role in flap compromise during microvascular flap surgeries. This article aimed to determine the expression profiles of miRs in rat flap surgeries after IRI. Vessel specimens ...
Chen Kuei-Min - - 2012
: Having a better comprehension of older adults' physical health can help healthcare professionals better design program activities to maintain and promote the health of this population. : This study investigated the physical health of community-dwelling older adults and compared physical health differences among different age subgroups, gender, and exercise ...
Zupa Angela - - 2012
: An understanding of the activated protein signaling architecture in non-small-cell lung cancer (NSCLC) is of critical importance to the development of new therapeutic approaches and identification of predictive and prognostic biomarkers for patient stratification. : We used reverse-phase protein microarrays to map the activated protein signaling networks of 47 ...
Kapell D N R G - - 2012
Leg health is an important component of broiler welfare and the economics of broiler production. This study presents the development of leg health in 3 purebred commercial broiler lines during 25 yr of selection and investigates the genetic background of leg health traits in current populations of these lines. The ...
Helland Aslaug - - 2012
: Asbestos-related malignant pleural mesothelioma is one of the most lethal tumor types. The advent of antimetabolite treatment as pemetrexed, introduced in the early 2000s, may have increased survival on a population basis. In this study, we have analyzed population-based incidence and survival data over the last 40 years. : ...
Mohiti-Asli M - - 2012
The effects of inclusion of cellulose or inulin as a source of dietary fiber and CP content of the diet on hepatic fat deposition were investigated in hens fed restricted or close to ad libitum consumption. There were 12 dietary treatments forming a 2 × 3 × 2 factorial with ...
Tang Yu-Wen - - 2012
Wide excision is the major recommendation for management of soft-tissue sarcomas. Pathologic reports of postexcision sarcomas revealed very close (within 2 mm) but clear excision margins. This investigation was a retrospective study to determine whether wide reexcision plus radiotherapy (R/T), or R/T only, yielded better outcomes. We evaluated our soft-tissue ...
Rowe Meredeth A - - 2012
At every stage of dementia, people with the condition are at risk for both missing incidents, in which they are unattended and unable to navigate a safe return to their caregiver, and "wandering," a term often used to describe repetitive locomotion with patterns such as lapping or pacing. By understanding ...
West Gordon - - 2012
Data from the Military Nursing Outcomes Database (MilNOD) project demonstrate that inadequately staffed shifts can increase the likelihood of adverse events, such as falls with injury, medication errors, and needlestick injuries to nurses. Such evidence can be used to show that it takes not only the right number of nursing ...
Minatel Emilio - - 2012
This study aimed to assess the safety of high doses of radiation delivered with tomotherapy to the intact lung after radical pleurectomy/decortication or biopsy for malignant pleural mesothelioma (MPM). Twenty-eight patients were enrolled in this prospective study and underwent adjuvant or definitive tomotherapy after radical pleurectomy/decortication (n = 20) or ...
D'Angelo Sandra P - - 2012
EGFR and KRAS mutations are mutually exclusive and predict outcomes with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment in patients with stage IV lung cancers. The clinical significance of these mutations in patients with resected stage I-III lung cancers is unclear. At our institution, resection specimens from ...
Matsubara Daisuke - - 2012
Rearranged during transfection (RET) fusions have been newly identified in approximately 1% of patients with primary lung tumors. However, patient-derived lung cancer cell lines harboring RET fusions have not yet been established or identified, and therefore, the effectiveness of an RET inhibitor on lung tumors with endogenous RET fusion has ...
Di Maio Massimo - - 2012
The TORCH (Tarceva or Chemotherapy) trial randomized patients with advanced non-small-cell lung cancer to first-line erlotinib followed by second-line cisplatin/gemcitabine versus. standard inverse sequence. The trial, designed to test noninferiority in overall survival, was stopped at interim analysis because of inferior survival in the experimental arm. Quality of life (QoL), ...
Matsumiya Wataru - - 2012
Multidrug resistance protein 4 (MRP4) effluxes a wide variety of endogenous compounds, including cyclic adenosine monophosphate (cAMP), and is exclusively expressed in vascular endothelial cells (ECs) of the retina. This study aimed to investigate the role of MRP4 in retinal vascular development. The retinal vascular phenotype of Mrp4(-/-) mice was ...
Springelkamp Henriët - - 2012
To determine, first, which regions of 3-D optical coherence tomography (OCT) volumes can be segmented completely in the majority of subjects and, second, the relationship between analyzed area and thickness measurement test-retest variability. Three-dimensional OCT volumes (6 × 6 mm) centered around the fovea and optic nerve head (ONH) of ...
Olson-Manning Carrie F - - 2012
Adaptive evolution is shaped by the interaction of population genetics, natural selection and underlying network and biochemical constraints. Variation created by mutation, the raw material for evolutionary change, is translated into phenotypes by flux through metabolic pathways and by the topography and dynamics of molecular networks. Finally, the retention of ...
Scagliotti Giorgio Vittorio - - 2012
Denosumab, a fully human anti-RANKL monoclonal antibody, reduces the incidence of skeletal-related events in patients with bone metastases from solid tumors. We present survival data for the subset of patients with lung cancer, participating in the phase 3 trial of denosumab versus zoledronic acid (ZA) in the treatment of bone ...
Fujimoto Junya - - 2012
Understanding oncogenes and tumor suppressor genes expression patterns is essential for characterizing lung cancer pathogenesis. We have previously demonstrated that mGprc5a/hGPRC5A is a lung-specific tumor suppressor evidenced by inflammation-mediated tumorigenesis in Gprc5a-knockout mice. The implication of GPRC5A in human lung cancer pathogenesis, including that associated with inflammatory chronic obstructive pulmonary ...
Hatziioannou Theodora - - 2012
The AIDS pandemic continues to present us with unique scientific and public health challenges. Although the development of effective antiretroviral therapy has been a major triumph, the emergence of drug resistance requires active management of treatment regimens and the continued development of new antiretroviral drugs. Moreover, despite nearly 30 years ...
Holstein Andreas - - 2012
The cytochrome P4502C enzymes account for the metabolism of approximately 20% of therapeutic drugs including certain oral antidiabetic drugs (OADs). This review focuses on the effect of CYP2C enzymes on metabolism of sulphonylureas (SUs), meglitinides, and thiazolidinediones (TZDs) discussing their impact on pharmacokinetics, drug interactions and toxicological profiles. Pharmacogenetic aspects ...
Sauler Maor M Section of Pulmonary and Critical Care Medicine, Yale School of Medicine, 15 York Street, New Haven, CT 06510, - - 2012
With the introduction of new materials and changes in manufacturing practices, occupational health investigators continue to uncover associations between novel exposures and chronic forms of diffuse parenchymal lung disease and terminal airways disease. To discern exposure-disease relationships, clinicians must maintain a high index of suspicion for the potential toxicity of ...
Rondina Matthew T MT Division of General Internal Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, - - 2012
F-FDG PET has been used for vascular disease, but its role in deep vein thrombosis (DVT) remains prospectively unexplored. Whole-body F-FDG PET/CT scans were performed in patients 1 to 10 weeks after onset of symptomatic DVT (n = 12) and in control subjects without DVT (n = 24). The metabolic ...
Heist Rebecca S RS Department or Thoracic Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA. - - 2012
Amplification of fibroblast growth factor receptor 1 (FGFR1) has been reported in squamous cell lung carcinoma and may be a molecular target for therapy. Little is known, however, about the clinical and demographic correlates of FGFR1 amplification. The study is an Institutional Review Board approved retrospective analysis of 226 patients ...
Weickhardt Andrew J AJ Department of Medicine, Division of Medical Oncology, University of Colorado Cancer Center, Colorado 80045, USA. - - 2012
Many patients with oncogene-driven non-small-cell lung cancer (NSCLC) treated with tyrosine kinase inhibitors experience limited sites of disease progression. This study investigated retrospectively the benefits of local ablative therapy (LAT) to central nervous system (CNS) and/or limited systemic disease progression and continuation of crizotinib or erlotinib in patients with metastatic ...
Sood Akshay A Department of Medicine, School of Medicine, Health Sciences Center, University of New Mexico, 1 University of New Mexico, MSC 10 5550, Albuquerque, NM 87131, USA. - - 2012
Almost 3 billion people worldwide burn solid fuels indoors. Despite the large population at risk worldwide, the effect of exposure to indoor solid fuel smoke has not been adequately studied. Indoor air pollution from solid fuel use is strongly associated with chronic obstructive pulmonary disease, acute respiratory tract infections, and ...
Gonzalez Carlos C Department of Clinical Psychology, Hospital Divino Espírito Santo, Ponta Delgada, - - 2012
The present study on long-term outcome of presymptomatic testing for Machado-Joseph disease (MJD) aimed to evaluate the psychological well-being and the familial satisfaction of subjects that 5 years prior received an unfavorable result in the predictive testing (PT). The study included 47 testees of Azorean origin (23 from the island ...
Li Tianjie T National Laboratory of Medical Molecular Biology, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Beijing, - - 2012
Alpha-2-adrenergic receptor (ADRA2A) is involved in the sympathetic nervous system and plays a role in the regulation of insulin secretion and lipolysis. Recent studies have indicated that the ADRA2A polymorphisms are associated with type 2 diabetes (T2DM) in Caucasians and African Americans. The present study aimed to evaluate the association ...
Cardarella Stephanie S Department of Medical Oncology, Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. - - 2012
Genomic testing to identify driver mutations that enable targeted therapy is emerging for patients with non-small-cell lung cancer (NSCLC). We report the implementation of systematic prospective genotyping for somatic alterations in BRAF, PIK3CA, HER2, and ALK, in addition to EGFR and KRAS, in NSCLC patients at the Dana-Farber Cancer Institute. ...
Wei Li L Medicines Monitoring Unit, School of Medicine, Division of Medical Sciences, Centre for Academic Clinical Practice, Division of Clinical and Population Sciences and Education, University of Dundee, Ninewells Hospital & Medical School, Dundee, - - 2012
This study was carried out to determine whether pregnancy rate is reduced after appendicitis or appendicectomy. The association between appendicectomy, appendicitis, and subsequent fertility is controversial. A cohort study was carried out in the Medicines Monitoring database. The cohort of women who underwent appendicectomy and appropriate comparators were followed up ...
Field R William RW Department of Occupational and Environmental Health, Department of Epidemiology, College of Public Health, University of Iowa, 105 River Street, Iowa City, IA 52242, USA. - - 2012
Because tobacco smoking is a potent carcinogen, secondary causes of lung cancer are often diminished in perceived importance. The goal of this review is to describe the occurrence and recent findings of the 27 agents currently listed by the International Agency for Research on Cancer (IARC) as lung carcinogens. The ...
Yang Jui-Yung JY Linkou Burn Center, Department of Plastic Surgery, Chang Gung Memorial Hospital and University, Taoyuan, Taiwan. - - 2012
Intrascar excision with debulking procedure is a good choice for scar revision in unique 3-dimensional facial aesthetic units, especially in the auricular area. It can remove or reduce scars in a shorter course without distortion of the surrounding anatomic structures and visible operative scars. This retrospective study was done to ...
Schon Eric A EA Department of Neurology, Columbia University Medical Center, 630 West 168th Street, New York, New York 10032, USA. - - 2012
Mutations in the human mitochondrial genome are known to cause an array of diverse disorders, most of which are maternally inherited, and all of which are associated with defects in oxidative energy metabolism. It is now emerging that somatic mutations in mitochondrial DNA (mtDNA) are also linked to other complex ...
Debnam J Matthew JM Section of Neuroradiology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77005, USA. - - 2012
Cross-sectional imaging plays an important role in the evaluation of the retropharyngeal space (RPS) and the prevertebral space (PVS). Because of their deep location within the neck, lesions arising within these spaces are difficult, if not impossible, to evaluate on clinical examination. This article details the cross-sectional anatomy and imaging ...
Pandey Mukesh K - - 2012
In vivo imaging of regional fatty acid oxidation (FAO) rates would have considerable potential for evaluation of mammalian diseases. We have synthesized and evaluated 18F-labeled thia fatty acid analogues as metabolically trapped FAO probes to understand the effect of chain length, degree of unsaturation, and placement of the thia substituent ...
Milner Phillip J PJ Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United - - 2012
A series of monoligated L·Pd(II)(Ar)X complexes (L = dialkyl biaryl phosphine) have been prepared and studied in an effort to better understand an unusual dearomative rearrangement previously documented in these systems. Experimental and theoretical evidence suggest a concerted process involving the unprecedented Pd(II)-mediated insertion of an aryl group into an ...
Bayyareddy Krishnareddy K Department of Entomology, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United - - 2012
Lipid rafts are microdomains in the plasma membrane of eukaryotic cells. Among their many functions, lipid rafts are involved in cell toxicity caused by pore forming bacterial toxins including Bacillus thuringiensis (Bt) Cry toxins. We isolated lipid rafts from brush border membrane vesicles (BBMV) of Aedes aegypti larvae as a ...
Kang Kai - - 2012
This study investigated whether cytokine enhancement of a biodegradable patch could restore cardiac function after surgical ventricular restoration (SVR) even when seeded with cells from old donors. SVR can partially restore heart size and improve function late after an extensive anterior myocardial infarction. However, 2 limitations include the stiff synthetic ...
Hoefen Ryan - - 2012
The study was designed to assess the ability of computer-simulated electrocardiography parameters to predict clinical outcomes and to risk-stratify patients with long QT syndrome type 1 (LQT1). Although attempts have been made to correlate mutation-specific ion channel dysfunction with patient phenotype in long QT syndrome, these have been largely unsuccessful. ...
Flather Marcus - - 2012
This study sought to assess whether patient age modifies the comparative effectiveness of coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI). Increasingly, CABG and PCI are performed in older patients to treat multivessel disease, but their comparative effectiveness is uncertain. Individual data from 7,812 patients randomized in ...
Koc-Zorawska Ewa - - 2012
Background/Aims: VAP-1 (vascular adhesion protein-1) is a copper-containing SSAO (semicarbazide sensitive amine oxidase) secreted by vascular smooth muscle cells, adipocytes, endothelial cells with functional monoamine oxidase activity. The oxidation process generates harmful products that may be involved in atherosclerosis and vascular damage. Elevation of SSAO activity is observed in atherosclerosis, ...
Ohashi Yasushi - - 2012
Background/Aims: Obesity and hypervolemic status are the main causes of hypertension in patients with chronic kidney disease (CKD). However, it is difficult to differentiate between them. We aimed to assess the associations of body mass index (BMI) and total body water (TBW) with ambulatory blood pressure (ABP). Methods: Body composition ...
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