Search Results
Results 701 - 750 of 2118
< 10 11 12 13 14 15 16 17 18 19 20 >
Liu Yaowen - - 2012
Spatial arrangement of multiple cell types plays a critical role in maintaining the viability of cells and functionality of tissues. Micropatterning has been used to fabricate scaffolds to modulate cell distribution, growth and functions for reconstructing the anisotropy in native tissues. In current study a glass substrate patterned with an ...
Snyder Christine M CM Department of Biology, Program in Cell and Molecular Biology, Boston University, Boston, MA 02215, - - 2013
Understanding the molecular mechanisms of skeletal muscle regeneration is crucial to exploiting this pathway for use in tissue repair. Our data demonstrate that the MEF2A transcription factor plays an essential role in skeletal muscle regeneration in adult mice. Injured Mef2a knockout mice display widespread necrosis and impaired myofiber formation. MEF2A ...
Eun Suk Ho SH Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, - - 2013
In many adult stem cell lineages, the continuous production of functional differentiated cells depends on the maintenance of progenitor cells in an undifferentiated and proliferative state, as well as the subsequent commitment to proper terminal differentiation. In the Drosophila male germline stem cell (GSC) lineage, a key differentiation factor, Bag ...
Cheng Chong - - 2012
Graphene oxide (GO), reduced graphene oxide (rGO), and their derivatives are investigated for various biomedical applications explosively. However, the defective biocompatibility was also recognized, which restricted their potential applications as biomaterials. In this study, a facile biomimetic approach for preparation of biopolymer adhered GO (rGO) with controllable 2D morphology and ...
Li Yan-Yan - - 2012
A novel series of homometallic and heterometallic lanthanide (Eu(3+)(Tb(3+))-Gd(3+)) hybrid silica microspheres (EDTA-(Eu(Tb)-Gd)-TTA-SiO(2)) are synthesized with 2-thenoyltrifluoroacetone (TTA) functionalized silane and ethylenediaminetetraacetic acid (EDTA) by sol-gel process, whose physical characterization are carried out and especially the luminescence and the magnetic resonance imaging (MRI) contrast agent properties are discussed. These hybrids ...
Stavropoulos-Kalinoglou Antonios A Department of Rheumatology, Dudley Group NHS Foundation Trust, Russell's Hall Hospital, Dudley, - - 2013
Low cardiorespiratory fitness (CRF) is a significant predictor of cardiovascular disease (CVD), and interventions aiming at increasing CRF are known to reduce CVD risk. The effects of such interventions on CVD risk have not been studied in patients with rheumatoid arthritis (RA). 40 age, gender, body mass index (BMI) and ...
Bingham Trista A TA HIV Epidemiology Program, Los Angeles County Department of Public Health, Los Angeles, CA 90005, USA. - - 2013
We investigated whether high gender role conflict (GRC; internal conflict with traditional gender-role stereotypes and an individual's perceived need to comply with these roles) is associated with psychological distress and HIV-related risk behaviors in a sample of African American men who have sex with men and women (MSMW). We analyzed ...
Telsemeyer Julia - - 2012
High dose gradients are inherent to ion beam therapy. This results in high sensitivity to discrepancies between planned and delivered dose distributions. Therefore an accurate knowledge of the ion stopping power of the traversed tissue is critical. One proposed method to ensure high quality dose deposition is to measure the ...
Yang Xin - - 2012
Nitrogenous disinfection byproducts (N-DBPs) such as haloacetonitriles (HANs) and halonitromethanes (HNMs) are formed during water chlorination. Preozonation is sometimes applied to control trihalomethane (THM) formation, but this may risk promoting the formation of HNMs and HANs. The role of ozone in the formation of HANs and HNMs in natural waters ...
Stegeman Gregory W - - 2012
Temperature-dependent behaviours in C. elegans, such as thermotaxis and isothermal tracking, are complex behavioral responses that integrate sensation, foraging and learning, and have driven investigations to discover many essential genetic and neural pathways. The ease of manipulation of the Caenorhabditis model system also has encouraged its application to comparative analyses ...
Lin Chenxiang - - 2013
Most previously reported methods for purifying DNA-origami nanostructures rely on agarose-gel electrophoresis (AGE) for separation. Although AGE is routinely used to yield 0.1-1 µg purified DNA nanostructures, obtaining >100 µg of purified DNA-origami structure through AGE is typically laborious because of the post-electrophoresis extraction, desalting and concentration steps. Here, we ...
Smith Stacey D SD Department of Biology, Duke University, USA. - - 2013
Dissecting the genetic basis for the evolution of species differences requires a combination of phylogenetic and molecular genetic perspectives. By mapping the genetic changes and their phenotypic effects onto the phylogeny, it is possible to distinguish changes that may have been directly responsible for a new character state from those ...
Claro Tania - - 2012
Staphylococcus aureus is the major pathogen of the genus staphylococci and the most common cause of bone infections. These infections are mainly characterized by bone destruction and inflammation and are often debilitating and very difficult to treat. Previously we demonstrated that S. aureus protein A (SpA) can bind to osteoblasts ...
Nagaoka Shin-Ichi - - 2012
Time-resolved emission of aloesaponarin I was studied with the fluorescence up-conversion and time-correlated single-photon-counting techniques. The rates of the excited-state intramolecular proton transfer, of the solvent and molecular rearrangements, and of the decay from the excited proton-transferred species were determined and interpreted in light of time-dependent density functional calculations. These ...
Lund Brian C - - 2012
OBJECTIVE: Practice guidelines used in the Veterans Health Administration (VHA) caution against benzodiazepine use by veterans with posttraumatic stress disorder (PTSD) because of inefficacy and safety concerns. Although use has declined, the VHA prescription rate is ≥30% nationally. To inform intervention design, this study examined patient- and facility-level correlates of ...
Gardner Eugene J EJ Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland 21218, - - 2012
To compare nuclear and cytoplasmic RNA from a single cell type, free of cross-contamination, we studied the oocyte of the frog Xenopus tropicalis, a giant cell with an equally giant nucleus. We isolated RNA from manually dissected nuclei and cytoplasm of mature oocytes and subjected it to deep sequencing. Cytoplasmic ...
Aydogan F - - 2012
Purpose:We aimed to evaluate the articular involvements in pediatric patients with familial Mediterranean fever (FMF) with joint symptoms by bone scintigraphy and to correlate the involved joints with the gene mutations.Materials and methods:A total of 41 newly diagnosed patients in pediatric age group (28 girls and 13 boys; mean age ...
Krieger Nancy - - 2012
How we think about biology-in historical, ecological, and societal context-matters for framing causes of and solutions to health inequities. Drawing on new insights from ecological evolutionary developmental biology and ecosocial theory, I question dominant gene-centric and ultimately static approaches to conceptualizing biology, using the example of the breast cancer estrogen ...
Deeds Daniel A - - 2012
Twenty-four halogenated volatile organic compounds (hVOCs) and SF6 were measured in groundwater samples collected from 312 wells across California at concentrations as low as 10(-12) grams per kilogram groundwater. The hVOCs detected are predominately anthropogenic (i.e. "ahVOCs") and as such their distribution delineates where groundwaters are impacted and susceptible to ...
Poineau Frederic - - 2012
Technetium is intimately linked with nuclear reactions. The ultraminute natural levels in the environment are due to the spontaneous fission of uranium isotopes. The discovery of technetium was born from accelerator reactions, and its use and presence in the modern world are directly due to nuclear reactors. While occupying a ...
Berger Slava - - 2012
RATIONALE: Mobilization and functions of endothelial progenitor cells (EPCs) are increased in acute myocardial infarction (AMI) patients. Yet, sleep disordered breathing (SDB) is highly prevalent in AMI patients. OBJECTIVE: To compare EPCs numbers and functions in AMI patients with SDB (AMI-SDB) and without SDB (AMI-only) and to determine the effects ...
Baek Dongwon D Division of Applied Life Science-BK21 Program, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-701, - - 2013
Although a role for microRNA399 (miR399) in plant responses to phosphate (Pi) starvation has been indicated, the regulatory mechanism underlying miR399 gene expression is not clear. Here, we report that AtMYB2 functions as a direct transcriptional activator for miR399 in Arabidopsis (Arabidopsis thaliana) Pi starvation signaling. Compared with untransformed control ...
Meyer Laurence R - - 2013
The University of California Santa Cruz (UCSC) Genome Browser (http://genome.ucsc.edu) offers online public access to a growing database of genomic sequence and annotations for a wide variety of organisms. The Browser is an integrated tool set for visualizing, comparing, analysing and sharing both publicly available and user-generated genomic datasets. As ...
Godlaski Theodore M - - 2012
The use of tobacco by Native Americans in North America seems to have ancient origins and significant spiritual meaning. This article reviews archeological and anthropological data about the use of tobacco and its sacred significance.
Chang Pi-Yueh - - 2012
Abstract Background: Oral cavity cancer ranks as the fourth leading cancer in men in Taiwan. The development of a serum biomarker panel for early detection and disease monitoring is, therefore, warranted. Methods: Nine inflammation-associated markers were investigated in 46 patients with leukoplakia, 151 patients with untreated oral cavity squamous cell ...
Meyer Sascha - - 2012
Most commonly pineal cysts are small, benign and asymptomatic lesions. Conversely, symptomatic pineal cysts are usually larger than those found incidentally. The incidence of symptomatic pineal cysts is highest in young women between 21 and 30 years of age, leading to the hypothesis that hormonal influences contribute to their etiology ...
Bao Bo - - 2012
Monitoring of sequestered carbon is essential to establishing the environmental safety and the efficacy of geological carbon sequestration. Sequestration in saline aquifers requires the detection of supercritical CO2 and CO2-saturated brine as distinct from the native reservoir brine. Here we demonstrate an all-optical approach to detect both supercritical CO2, and ...
Blair Irene V IV Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309-0345, USA. - - 2013
We assessed implicit and explicit bias against both Latinos and African Americans among experienced primary care providers (PCPs) and community members (CMs) in the same geographic area. Two hundred ten PCPs and 190 CMs from 3 health care organizations in the Denver, Colorado, metropolitan area completed Implicit Association Tests and ...
Winter Anke C AC Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, - - 2013
Previous studies suggest an association between migraine and restless legs syndrome (RLS). Population-based data, however, have been limited to women. The aim of this study is to evaluate the association between migraine and RLS in a male cohort. We conducted a cross-sectional study among 22,926 participants in the Physicians' Health ...
Wang Si S Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 90237, - - 2013
YSA is an EphA2-targeting peptide that effectively delivers anticancer agents to prostate cancer tumors. Here, we report on how we increased the drug-like properties of this delivery system. By introducing non-natural amino acids, we have designed two new EphA2 targeting peptides: YNH, where norleucine and homoserine replace the two methionine ...
Yasuda Takashi - - 2012
Suppression of the renin-angiotensin system is known to slow progression of chronic kidney disease (CKD). However, few trials have been performed with Japanese patients. This study investigated whether the angiotensin receptor blocker (ARB) valsartan would delay the progression of kidney disease more effectively than conventional treatment in Japanese hypertensive patients ...
Lupattelli T - - 2012
Chronic cerebrospinal venous insufficiency (CCSVI) is a syndrome characterized by stenoses of the internal jugular veins (IJVs) and/or azygos veins and formation of collateral venous channels. A case of a 57-year-old patient with CCSVI in whom the venous outflow from the left IJV to the right atrium occurred through a ...
Hashimoto Sayuki - - 2012
Aim: To investigate the acute effects of postprandial exercise on glucose and lipoprotein metabolism after the intake of glucose with or without fat cream in healthy but sedentary young women.Methods: Healthy young Japanese women with a sedentary lifestyle, normal weight (18.5≤BMI<25), normal ovarian cycle, and apolipoprotein (apo) E3/3 were enrolled ...
Chakraborty K - - 2012
Chronic myeloid leukemia is characterized by a unique reciprocal translocation between chromosomes 9 and 22 resulting in deregulated tyrosine kinase activity. Tyrosine kinase inhibitors, such as imatinib, dasatinib, and nilotinib have revolutionized treatment of Chronic myeloid leukemia. However, tyrosine kinase inhibitors' use has presented new challenges in managing both acute ...
Kim Bo Heum - - 2012
Liquid-sucking phenomena by the two-pump system of a female mosquito have been investigated experimentally to understand the feeding mechanism. In most previous experimental studies on liquid-feeding insects, the net increase of mass was divided by the feeding time and fluid density to evaluate the intake rate. However, this weighting method ...
Lulli Matteo - - 2012
Purpose. To evaluate if coenzyme Q10 (CoQ10) can protect retinal ganglion cells (RGCs) from apoptosis and, when instilled as eye drops on the cornea, if it can reach the retina and exert its antiapoptotic activity in this area in a mouse model of kainate (KA)-induced retinal damage. Methods. Rat primary ...
Asaoka Ryo - - 2012
PURPOSE: To infer the combination of visual field (VF) test points, taken from a newly created visual field test grid centred at the optic disc (disc-centred field; DCF) and the conventional fovea-centred 24-2 grid (24-2) of standard automated perimetry (SAP), which yields the strongest structure-function relationship indicated by the correlation ...
Gagnon Daniel D Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, - - 2013
The current study aimed to determine whether a peripheral modulation of sweating contributes to the lower sudomotor thermosensitivity previously observed in females during exercise. We examined dose-response relationships in 12 males and 12 females to incremental doses of acetylcholine (ACh) and methylcholine (MCh) for sweating (ventilated capsule), as well as ...
Ródenas Sergio - - 2012
OBJECTIVE: To report the clinical, imaging, pathologic findings, surgical planning, and long-term outcome after surgery in a dog with neurologic deficits because of a hypertrophic ganglioneuritis that compressed the spinal cord. STUDY DESIGN: Clinical report. ANIMAL: An 8-year-old male intact Yorkshire terrier. METHODS: The dog had ambulatory tetraparesis and neurologic ...
Jin Shubin S Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, Beijing, - - 2013
We investigated the penetration and thermotherapy efficiency of different surface coated gold nanorods (Au NRs) in multicellular tumor spheroids. The current data show that negatively charged Au NRs, other than positively charged Au NRs, can penetrate deep into the tumor spheroids and achieve a significant thermal therapeutic benefit.
Escalante Andrea M - - 2012
Sequential activation of different reversible exchange reactions in a dynamic combinatorial library allows directed exploration of the chemical space: initially a macrocyclic scaffold is selected by the template and finally side chain and conformational constrains are introduced into such a scaffold.
Tsuneyoshi Norihiro - - 2012
Activin/Nodal signaling via SMAD2/3 maintains human embryonic stem cell (hESC) pluripotency by direct transcriptional regulation of NANOG or, alternatively, induces mesoderm and definitive endoderm (DE) formation. In search of an explanation for these contrasting effects, we focused on SNON (SKIL), a potent SMAD2/3 corepressor that is expressed in hESCs but ...
Brown Geoffrey - - 2012
Since the early 1980s, developing haematopoietic cells have been categorised into three well-defined compartments: multi-potent haematopoietic stem cells (HSC), which are able to self-renew, followed by haematopoietic progenitor cells (HPC), which undergo decision-making and age as they divide rather than self-renew, and the final compartment of functional blood and immune ...
Du Zhenting - - 2012
The combination of transition metal catalysis and organocatalysis as a new and exciting research area has attracted increasing attention as it can enable the development of unprecedented transformations that is not possible by use of either of the catalytic systems alone, and can improve the reactivity, efficiency and stereocontrol of ...
Maekawa Shun - - 2012
Hematopoietic responses to environmental factors are not fully characterized. Polycythemia has been reported during exposure to low temperatures in ectothermic animals. The relationship between the causes of polycythemia and erythropoiesis during low-temperature exposure is not fully understood. In this study, we exposed C57BL/6 mice to 5°C and monitored the blood ...
Hartwig Andreas - - 2013
Myopia incidence is increasing around the world. Myopization is considered to be caused by a variety of factors. One consideration is whether higher-order aberrations (HOA) influence myopization. More knowledge of optics in anisometropic eyes might give further insight into the development of refractive error. To analyze the possible influence of ...
Moore Simon J SJ School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United - - 2013
The anaerobic pathway for the biosynthesis of cobalamin (vitamin B(12)) has remained poorly characterized because of the sensitivity of the pathway intermediates to oxygen and the low activity of enzymes. One of the major bottlenecks in the anaerobic pathway is the ring contraction step, which has not been observed previously ...
Atmaca Akin - - 2012
ABSTRACT: BACKGROUND: The epidermal growth factor receptor (EGFR) is a potential target of anticancer therapy in gastric cancer. However, its prognostic role in metastatic gastric or gastroesophageal junction (GE) cancer has not been established yet. METHODS: EGFR status was analyzed by immunohistochemistry (IHC) in paraffin-embedded samples from 357 patients who ...
Pantoja Mario M Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, - - 2013
Duchenne muscular dystrophy is a lethal genetic disease characterized by the loss of muscle integrity and function over time. Using Drosophila, we show that dystrophic muscle phenotypes can be significantly suppressed by a reduction of wunen, a homolog of lipid phosphate phosphatase 3, which in higher animals can dephosphorylate a ...
Gebb Sarah A - - 2012
Background: Numerous studies in cultured cells indicate that damage to mitochondrial DNA (mtDNA) dictates cellular responses to oxidant stress, yet the consequences of mtDNA damage have not been studied directly in the preterm lung. Objective: We sought to determine whether hyperoxia-induced fetal lung dysmorphogenesis is linked to mtDNA damage and ...
< 10 11 12 13 14 15 16 17 18 19 20 >