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Results 701 - 750 of 2119
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Lee Mi-Sun - - 2013
We examined the association between household solid fuel exposure and lung function in a densely populated district in urban Shanghai, China. Spirometry was performed in 12 506 subjects, aged 18 and over, residing in the Putuo District in Shanghai, China, in a cross-sectional survey. Exposure to solid fuel use at ...
Lin Chenxiang - - 2013
Most previously reported methods for purifying DNA-origami nanostructures rely on agarose-gel electrophoresis (AGE) for separation. Although AGE is routinely used to yield 0.1-1 µg purified DNA nanostructures, obtaining >100 µg of purified DNA-origami structure through AGE is typically laborious because of the post-electrophoresis extraction, desalting and concentration steps. Here, we ...
Haque Aftabul - - 2012
We describe a phage display approach that we have previously used to generate conformation-sensor antibodies that specifically recognize and stabilize the oxidized, inactive conformation of protein tyrosine phosphatase 1B (PTP1B). We use a solution-based panning and screening strategy conducted in the presence of reduced active PTP1B, which enriches antibodies to ...
Nielsen Klaus H - - 2012
During pre-mRNA splicing, the spliceosome is activated for catalysis by unwinding base-paired U4/U6 small nuclear RNAs, a step that must be precisely timed. We know that unwinding requires the ATPase Brr2, but the mechanism and regulation of unwinding have been understood poorly. In the November 1, 2012, issue of Genes ...
Olson Janet E - - 2012
ABSTRACT: INTRODUCTION: Mammographic density is a strong risk factor for breast cancer. Image acquisition technique varies across mammograms to limit radiation and produce a clinically useful image. We examined whether acquisition technique parameters at the time of mammography were associated with mammographic density and whether the acquisition parameters confound the ...
Passet Bruno - - 2012
Although the pivotal implication of the host-encoded Prion protein, PrP, in the neuropathology of transmissible spongiform encephalopathy is known for decades, its biological role remains mostly elusive. Genetic inactivation is one way to assess such issue but, so far, PrP-knockout mice did not help much. However, recent reports involving (1) ...
Dodson Reuben Blair - - 2013
Fetal intrauterine growth restriction (IUGR) results in increased placental resistance to blood flow, fetal hypertension, and increased pulsatility stresses shown to lead to vascular remodeling. We tested our hypothesis that IUGR causes decreased compliance in the carotid and umbilical arteries due to altered extracellular matrix (ECM) composition and structure. A ...
Bacaksiz Ahmet - - 2013
Psoriasis vulgaris is one of the most common skin disorders. Patients with psoriasis carry an excessive risk of atrial fibrillation (AF). The differences between the maximum (Pmax) and the minimum (Pmin) P-wave duration on ECG are defined as P-wave dispersion (PWD). Prolongation of PWD is an independent risk factor for ...
Kim Hyun-Jun - - 2013
We examined whether nonresponse to the survey question on self-identified sexual orientation was associated with race and ethnicity, utilizing Washington State Behavioral Risk Factor Surveillance System data. The results of adjusted multinomial logistic regression indicated that the nonresponse rates of Asian Americans, Hispanics, and African Americans are higher than those ...
Kohn Tertius A - - 2013
This study investigated for the first time maximum force production, shortening velocity (Vmax) and power output in permeabilised single muscle fibres at 12°C from lion, Panthera leo (Linnaeus 1758), and caracal, Caracal caracal (Schreber 1776), and compared the values with those from human cyclists. Additionally, the use and validation of ...
Campos-Rodriguez Francisco - - 2013
Obstructive sleep apnea (OSA) has been associated with increased cancer mortality, but whether it is also associated with cancer incidence is unknown. To investigate whether OSA is associated with increased cancer incidence in a large clinical cohort. A multicenter, clinical cohort study including consecutive patients investigated for suspected OSA between ...
Ryan Terence E - - 2013
Near-infrared spectroscopy (NIRS) can be used to measure muscle oxygen consumption (mVO(2)) using arterial occlusions. The recovery rate of mVO(2) after exercise can provide an index of skeletal muscle mitochondrial function. The purpose of this study was to test the influence of exercise modality and intensity on NIRS measurements of ...
Kobayashi Tetsuo - - 2013
Losartan (Los) is a Food and Drug Administration-approved antihypertensive medication that has a well-tolerated side effect profile. We have demonstrated that treatment with Los immediately after injury was effective at promoting muscle healing and inducing an antifibrotic effect in a murine model of skeletal muscle injury. We initially investigated the ...
Rupp Thomas - - 2013
Performing exercise during the first hours of hypoxic exposure is thought to exacerbate acute mountain sickness (AMS), but whether this is due to increased hypoxemia or other mechanisms associated with exercise remains unclear. In 12 healthy men, AMS symptoms were assessed during three 11-h experimental sessions: 1) in Hypoxia-exercise, inspiratory ...
Salehin Mohammad - - 2012
Medicago truncatula NIP/LATD gene, required for symbiotic nitrogen fixing nodule and root architecture development, encodes a member of the NRT1(PTR) family that demonstrates high-affinity nitrate transport in Xenopus laevis oocytes. Of three Mtnip/latd mutant proteins, one retains high-affinity nitrate transport in oocytes, while the other two are nitrate-transport defective. To ...
Zhang Lingang - - 2012
VIPP1 protein in photosynthetic organisms is homologous to bacterial PspA, which protects plasma membrane integrity upon stresses. Despite the proposed role of VIPP1 in thylakoid biogenesis, its precise function remains unclear. Recently, our in-depth analysis of Arabidopsis vipp1 mutants revealed VIPP1's involvement in the maintenance of chloroplast envelopes. Chloroplasts in ...
Niehl Annette - - 2012
Cell-division-cycle protein 48 (CDC48) is an essential, conserved ATP-driven chaperone in eukaryotic cells, which functions in diverse cellular processes including the targeting of misfolded and aggregated proteins for degradation via proteasomal and aggresomal-autophagic pathways. We recently demonstrated that plant CDC48 localizes to and interacts with Tobacco mosaic virus (TMV) movement ...
Herrick Amy L - - 2013
We tested a theory of syndemic production among men who have sex with men (MSM) using data from a large cohort study. Participants were 1551 men from the Multicenter AIDS Cohort Study enrolled at 4 study sites: Baltimore, Maryland-Washington, DC; Chicago, Illinois; Los Angeles, California; and Pittsburgh, Pennsylvania. Participants who ...
Stefanis Nicholas C - - 2012
Genetic variability within the ZNF804A gene has been recently found to be associated with schizophrenia and bipolar disorder, although the pathways by which this gene may confer risk remain largely unknown. We set out to investigate whether common ZNF804A variants affect psychosis-related intermediate phenotypes such as cognitive performance dependent on ...
Voorhuis M - - 2013
Is there an association between the number of CGG repeats in the FMR1 gene in the normal and intermediate range and age at natural menopause? The number of CGG repeats in the normal and intermediate range in the FMR1 gene was not associated with age at natural menopause. Excessive triple ...
Hartwig Andreas - - 2013
Myopia incidence is increasing around the world. Myopization is considered to be caused by a variety of factors. One consideration is whether higher-order aberrations (HOA) influence myopization. More knowledge of optics in anisometropic eyes might give further insight into the development of refractive error. To analyze the possible influence of ...
Fedder J - - 2013
Does neonatal outcome including congenital malformations in children born after ICSI with epididymal and testicular sperm [testicular sperm extraction (TESE)/percutaneous epididymal sperm aspiration (PESA)/testicular sperm aspiration (TESA) (TPT)] differ from neonatal outcome in children born after ICSI with ejaculated sperm, IVF and natural conception (NC)? Children born after TPT have ...
Thomas-Teinturier Cécile - - 2013
Is the age at menopause in a cohort of childhood cancer survivors earlier and what are the risk factors associated with earlier age at menopause? Menopause occurred at a median age of 44 years in this cohort which is earlier than in the general population, but premature menopause was uncommon. ...
Hu Yin - - 2013
The RNA transcriptome varies in response to cellular differentiation as well as environmental factors, and can be characterized by the diversity and abundance of transcript isoforms. Differential transcription analysis, the detection of differences between the transcriptomes of different cells, may improve understanding of cell differentiation and development and enable the ...
Reinke Stacey N - - 2012
ABSTRACT: A report on the 7th annual Metabomeeting of the Metabolic Profiling Forum, University of Manchester, Manchester, UK, 25-27 September 2012.
Purtle Jonathan - - 2013
Approximately 13% of African American men are disqualified from voting because of a felony conviction. I used ecosocial theory to identify how institutionalized racism helps perpetuate health disparities and to explore pathways through which felon disenfranchisement laws may contribute to racial health disparities in the United States. From a literature ...
Liu Wenge W Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. - - 2012
Brachytherapy is a common clinical technique involving implantation of sealed radioactive "seeds" within a tumor to selectively irradiate the tumor mass while minimizing systemic toxicity. To mitigate the disadvantages associated with complex surgical implantation and subsequent device removal procedures, we have developed an alternative approach using a genetically encoded peptide ...
Kanduri Meena M Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg, - - 2012
Chronic lymphocytic leukemia (CLL) can be divided into prognostic subgroups based on the IGHV gene mutational status, and is further characterized by multiple subsets of cases with quasi-identical or stereotyped B cell receptors that also share clinical and biological features. We recently reported differential DNA methylation profiles in IGHV-mutated and ...
Liss Michael A MA Department of Urology, University of California, Irvine, Orange, CA, USA. - - 2012
Preservation of continence and sexual function continues to be a formidable quality-of-life issue regarding outcomes after radical prostatectomy. There is little argument that physical preservation of the nerves and sphincters is a critical component to achieving success in these domains. Previously demonstrated factors such as advancing age, deteriorating physical health ...
van der Steen Jenny T JT VU University Medical Center, EMGO Institute for Health and Care Research, Department of general practice & elderly care medicine, Amsterdam, the Netherlands. - - 2012
Selective participation in retrospective studies of families recruited after the patient's death may threaten generalizability of reports on end-of-life experiences. To assess possible selection bias in retrospective study of dementia at the end of life using family reports. Two physician teams covering six nursing home facilities in the Netherlands reported ...
Pithadia Amit S AS Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United - - 2012
In Alzheimer's disease (AD), metal-associated amyloid-β (metal-Aβ) species have been suggested to be involved in neurotoxicity; however, their role in disease development is still unclear. To elucidate this aspect, chemical reagents have been developed as valuable tools for targeting metal-Aβ species, modulating the interaction between the metal and Aβ, and ...
Kim Sunghee S Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United - - 2012
At -90 °C in acetone, a stable hydroperoxo complex [(BA)Cu(II)OOH](+) (2) (BA, a tetradentate N(4) ligand possessing a pendant -N(H)CH(2)C(6)H(5) group) is generated by reacting [(BA)Cu(II)(CH(3)COCH(3))](2+) with only 1 equiv of H(2)O(2)/Et(3)N. The exceptional stability of 2 is ascribed to internal H-bonding. Species 2 is also generated in a manner ...
Rechner Laura A LA Department of Radiation Physics, Graduate School of Biomedical Sciences, The University of Texas Health Science Center Houston, Houston, TX 77030, - - 2012
We previously determined that the predicted risk of radiogenic second cancer in the bladder and rectum after proton arc therapy (PAT) was less than or equal to that after volumetric modulated arc therapy (VMAT) with photons, but we did not consider the impact of margin size on that risk. The ...
Bouchoux Guillaume G Division of Cardiovascular Diseases, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, USA. - - 2012
The prevalence of stroke worldwide and the paucity of effective therapies have triggered interest in the use of transcranial ultrasound as an adjuvant to thrombolytic therapy. Previous studies have shown that 120 kHz ultrasound enhanced thrombolysis and allowed efficient penetration through the temporal bone. The objective of our study was to ...
Parati Gianfranco G Department of Health Sciences, University of Milano-Bicocca, Milan, Italy. - - 2013
Observational studies have shown that 24-h and morning ambulatory blood pressure (BP) control is low. This large-scale, practice-based study evaluated the effects of telmisartan 40 or 80 mg alone or in combination with hydrochlorothiazide (HCTZ) 12.5 mg on these BP parameters over 8 weeks; treatment was adjusted if clinic BP remained ≥140/90 mm Hg. ...
Blair Irene V IV Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309-0345, USA. - - 2013
We assessed implicit and explicit bias against both Latinos and African Americans among experienced primary care providers (PCPs) and community members (CMs) in the same geographic area. Two hundred ten PCPs and 190 CMs from 3 health care organizations in the Denver, Colorado, metropolitan area completed Implicit Association Tests and ...
Snyder Christine M CM Department of Biology, Program in Cell and Molecular Biology, Boston University, Boston, MA 02215, - - 2013
Understanding the molecular mechanisms of skeletal muscle regeneration is crucial to exploiting this pathway for use in tissue repair. Our data demonstrate that the MEF2A transcription factor plays an essential role in skeletal muscle regeneration in adult mice. Injured Mef2a knockout mice display widespread necrosis and impaired myofiber formation. MEF2A ...
Sur Shantanu S Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, Illinois 60611, - - 2012
Self-assembling peptide materials have been used extensively to mimic natural extracellular matrices (ECMs) by presenting bioactive epitopes on a synthetic matrix. Although this approach can facilitate a desired response from cells grown in the matrix, it lacks the capacity for spatial or temporal regulation of the presented signals. We describe ...
Tsang Jennifer J Department of Microbiology, University of Georgia, Athens, GA 30602, - - 2013
Flagellar biogenesis in the gastric pathogen Helicobacter pylori involves a transcriptional hierarchy that utilizes all three sigma factors found in this bacterium (RpoD, RpoN and FliA). Transcription of the RpoN-dependent genes requires the sensor kinase FlgS and response regulator FlgR. It is thought that FlgS senses some cellular cue to ...
Castle Philip E PE Albert Einstein College of Medicine, Bronx, NY, - - 2013
Human papillomavirus (HPV) RNA detection is reportedly more specific for the detection of anogenital precancer than HPV DNA but it is unknown whether this is due to detection of RNA or due to HPV genotype restriction. A total of 363 human immunodeficiency virus (HIV)-positive men who have sex with men ...
Takabayashi Tetsuji T Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, - - 2013
Nasal polyps (NPs) are characterized by intense edema or formation of pseudocysts filled with plasma proteins, mainly albumin. However, the mechanisms underlying NP retention of plasma proteins in their submucosa remain unclear. We hypothesized that formation of a fibrin mesh retains plasma proteins in NPs. We assessed the fibrin deposition ...
Wang Si S Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 90237, - - 2013
YSA is an EphA2-targeting peptide that effectively delivers anticancer agents to prostate cancer tumors. Here, we report on how we increased the drug-like properties of this delivery system. By introducing non-natural amino acids, we have designed two new EphA2 targeting peptides: YNH, where norleucine and homoserine replace the two methionine ...
Al-Zahrani Khalid N KN Ottawa Hospital Research Institute, Cancer Therapeutics, Ottawa, ON - - 2013
Reorganization of the cytoskeleton is necessary for apoptosis, proliferation, migration, development and tissue repair. However, it is well established that mutations or overexpression of key regulators contribute to the phenotype and progression of several pathologies such as cancer. For instance, c-src mutations and the overexpression of FAK have been implicated ...
Sundström Karin K Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, P.O. Box 281, S-171 77 Stockholm, Sweden. - - 2013
A strong association has been shown between high viral DNA load (VL) of human papillomavirus (HPV) type 16 and risk for cervical cancer in situ (CIS). However, little data is available for the significance of VL in invasive squamous cell carcinoma (SCC). In 2 nested case-control studies among women participating ...
Holmberg Johan J Muscle Biology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden. - - 2013
A chain is no stronger than its weakest link is an old idiom that holds true for muscle biology. As the name implies, skeletal muscle's main function is to move the bones. However, for a muscle to transmit force and withstand the stress that contractions give rise to, it relies ...
Bingham Trista A TA HIV Epidemiology Program, Los Angeles County Department of Public Health, Los Angeles, CA 90005, USA. - - 2013
We investigated whether high gender role conflict (GRC; internal conflict with traditional gender-role stereotypes and an individual's perceived need to comply with these roles) is associated with psychological distress and HIV-related risk behaviors in a sample of African American men who have sex with men and women (MSMW). We analyzed ...
Avanesov Andrei A Department of Zoology, University of Wisconsin, Madison, WI 53706, - - 2013
Hedgehog (Hh) family proteins are secreted signaling ligands whose short- and long-range activities transform cellular fates in multiple contexts in organisms ranging from metazoans to humans. In the developing Drosophila wing, extracellular Hh binds to cell-bound glypican heparan sulfate proteoglycans (HSPGs) and the secreted protein Shifted (Shf), a member of ...
Winter Anke C AC Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, - - 2013
Previous studies suggest an association between migraine and restless legs syndrome (RLS). Population-based data, however, have been limited to women. The aim of this study is to evaluate the association between migraine and RLS in a male cohort. We conducted a cross-sectional study among 22,926 participants in the Physicians' Health ...
van Bergen Diana D DD Department of Theory and Research in Education, Faculty of Psychology and Education, VU University Amsterdam, The Netherlands. - - 2013
We examined Netherlands Institute for Social Research data, collected between May and August 2009, on 274 Dutch lesbian, gay, and bisexual youths. The data showed that victimization at school was associated with suicidal ideation and actual suicide attempts. Homophobic rejection by parents was also associated with actual suicide attempts. Suicidality ...
Eun Suk Ho SH Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, - - 2013
In many adult stem cell lineages, the continuous production of functional differentiated cells depends on the maintenance of progenitor cells in an undifferentiated and proliferative state, as well as the subsequent commitment to proper terminal differentiation. In the Drosophila male germline stem cell (GSC) lineage, a key differentiation factor, Bag ...
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