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Schneider John A - - 2013
We evaluated network mixing and influences by network members upon Black men who have sex with men. We conducted separate social and sexual network mixing analyses to determine the degree of mixing on risk behaviors (e.g., unprotected anal intercourse [UAI]). We used logistic regression to assess the association between a ...
Wheeler David C DC Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7240, - - 2013
Evaluating occupational exposures in population-based case-control studies often requires exposure assessors to review each study participant's reported occupational information job-by-job to derive exposure estimates. Although such assessments likely have underlying decision rules, they usually lack transparency, are time consuming and have uncertain reliability and validity. We aimed to identify the ...
Hu Yuandu - - 2012
Soft photonic crystals (PC) are more appealing due to the responsiveness of the building blocking-deformable nanoparticles to the external stimuli. In this report, we demonstrate, for the first time, the generation of soft core/shell PC microspheres through a combination of a microfluidic technique, encapsulation of well-ordered temperature responsive polymer nanogels ...
Szymański P - - 2012
The aim of this study was to synthesize and determine the biological activity of new deri-vatives of 4-fluorobenzoic acid and tetrahydroacridine towards inhibition of cholinesterases. Compounds were synthesized in condensation reaction between 9-aminoalkyl-tetrahydroacri-dines and the activated 4-fluorobenzoic acid. Properties towards inhibition of acetyl- and butyrylcholinesterase were estimated according to Ellman's ...
Wonderlich Elizabeth R - - 2012
Dendritic cells (DC) are a heterogeneous population of innate immune cells that are fundamental to initiating responses against invading pathogens and regulating immune responses. Myeloid DC (mDC) act as a bridge between the innate and adaptive immune response during virus infections but their role in immunity to human immunodeficiency virus ...
O'Reilly D D Department of Pediatrics, Division of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, - - 2013
To evaluate the efficacy and safety of passive cooling during transport of asphyxiated newborns. Retrospective medical record review of newborns with perinatal asphyxia transported for hypothermia between July 2007 and June 2010. Of 43 newborns transported, 27 were passively cooled without significant adverse events. Twenty (74%) passively cooled newborns arrived ...
Aydin S - - 2012
Sepsis, often initiated by an infection, is a state of disrupted inflammatory homeostasis. There is increasing evidence that oxidative stress has an important role in the development of sepsis-induced multiorgan failure. Resveratrol (RV) is a polyphenolic compound found in the skin of red fruits, such as mulberries and red grapes, ...
Corrias Andrea - - 2012
Thyroid nodules are less frequent in childhood than in adulthood, but are more often malignant. Recent estimates suggest that up to 25% of thyroid nodules in children are malignant, therefore, a more aggressive approach is recommended. In this review, we suggest an approach based on a first-step clinical, laboratory, and ...
Sbrana Francesco - - 2012
A carbapenem-sparing regimen of tigecycline plus gentamicin or colistin was effective for treating 24/26 (92%) KPC-Kp infectious episodes in 22 polytrauma ICU patients without comorbidities. The 30-day crude mortality rate was 14%. Regimens were considered appropriate in 12% of episodes according to Vitek® 2 and in 100% based on E-test.
Baumann Patric - - 2012
Various domains present the challenges of responding to stimuli in a specific manner, with the desired sensitivity or functionality, and only when required. Stimuli-responsive systems that are appropriately designed can effectively meet these challenges. Here, we introduce nanoreactors that encapsulate photosensitizer-protein conjugates in polymer vesicles as a source of "on ...
Phan Nguyen - - 2012
Plant cells use sugars mainly as a source or store of energy and cytoskeletons for anabolic reactions and for osmotic regulation. The perception of sugars and their responses are rather complex including the heterotrimeric G protein pathway and a seven-transmembrane RGS molecule. Previously, we found that endocytosis of the 7TM-RGS ...
Smith Nicola C - - 2012
Abstract It is unclear whether small animals with their high stride frequency and crouched posture or large animals with more tendinous limbs are more reliant on storage and return of elastic energy during locomotion. The ostrich has a limb structure that appears to be adapted for high speed running with ...
Milanowska Kaja - - 2013
Many RNA molecules undergo complex maturation, involving e.g. excision from primary transcripts, removal of introns, post-transcriptional modification and polyadenylation. The level of mature, functional RNAs in the cell is controlled not only by the synthesis and maturation but also by degradation, which proceeds via many different routes. The systematization of ...
Sauer Désirée C - - 2012
The synthesis of a new family of chiral tridentate monoanionic NNN-pincer ligands based on the 1,3-bis(2-pyridylimino)isoindoline (BPI) framework is reported. Ligands with substituents of varying steric demand were prepared starting from achiral and low priced materials. A kinetic enzymatic resolution was used as a key step for the preparation of ...
Han Qing-Hua - - 2012
Lygodipenoids A (1) and B (2), two novel C33 tetracyclic triterpenoids with a new 9,19 : 24,32-dicyclopropane skeleton, were isolated from the whole grass of Lygodium japonicum. Their structures were elucidated by spectroscopic and chemical means. Compounds 1 and 2 were tested in transfected cultured human embryonic kidney 293 HEK293 cells for ...
Solomon Daniel H DH Division of Pharmacoepidemiology, Brigham and Women's Hospital, , Boston, Massachusetts, - - 2013
While heart failure (HF) is associated with elevations in tumor necrosis factor (TNF)α, several trials of TNF antagonists showed no benefit and possibly worsening of disease in those with known severe HF. We studied the risk of new or recurrent HF among a group of patients receiving these agents to ...
Kim Hyun-Jun HJ School of Social Work, University of Washington, Seattle, WA 98105, USA. - - 2013
We examined whether nonresponse to the survey question on self-identified sexual orientation was associated with race and ethnicity, utilizing Washington State Behavioral Risk Factor Surveillance System data. The results of adjusted multinomial logistic regression indicated that the nonresponse rates of Asian Americans, Hispanics, and African Americans are higher than those ...
An Qian - - 2012
Objectives. We examined the association between socioeconomic position (SEP) and HIV diagnosis rates in the United States and whether racial/ethnic disparities in diagnosis rates persist after control for SEP. Methods. We used cases of HIV infection among persons aged 13 years and older, diagnosed 2005 through 2009 in 37 states ...
Munene Esther - - 2012
In these colorful 2011 photographs, Burmese children are adorned with thanakha, a traditional decorative makeup. Thanakha (pronounced tha-na-KA) is obtained from grinding the bark of thanakha trees, which grow in Burma, Thailand, parts of India, and the Himalayas. Many different brands of this product are available commercially. The yellowish-white, creamy ...
Perret Jennifer L - - 2012
RATIONALE: The contribution by asthma to the development of fixed airflow obstruction and the nature of its effect combined with active smoking and atopy remain unclear. OBJECTIVES: To investigate the prevalence and relative influence of lifetime asthma, active smoking and atopy on fixed airflow obstruction in middle-age. METHODS: The population-based ...
Tuan Pham Anh - - 2012
Riboflavin (vitamin B2) is the universal precursor of the coenzymes flavin mononucleotide and flavin adenine dinucleotide-cofactors that are essential for the activity of a wide variety of metabolic enzymes in animals, plants, and microbes. Using the RACE PCR approach, cDNAs encoding lumazine synthase (McLS) and riboflavin synthase (McRS), which catalyze ...
van Lis Robert - - 2013
Eukaryotic algae have long been known to live in anoxic environments, but interest in their anaerobic energy metabolism has only recently gained momentum, largely due to their utility in biofuel production. Chlamydomonas reinhardtii figures remarkably in this respect, because it efficiently produces hydrogen and its genome harbors many genes for ...
Kennedy Andrew B - - 2013
Synthetic RNA control devices that use ribozymes as gene-regulatory components have been applied to controlling cellular behaviors in response to environmental signals. Quantitative measurement of the in vitro cleavage rate constants associated with ribozyme-based devices is essential for advancing the molecular design and optimization of this class of gene-regulatory devices. ...
Doran Neal - - 2012
This study tested whether DRD2/ANKK1 TaqIA genotype predicted smoking initiation and subsequent use, and effects were mediated by sensation seeking and negative urgency. Between 2009 and 2012, college never smokers (n = 387) completed six assessments over 15 months; those who reported smoking were classified as initiators. Logistic regression indicated ...
Voorhuis M - - 2013
Is there an association between the number of CGG repeats in the FMR1 gene in the normal and intermediate range and age at natural menopause? The number of CGG repeats in the normal and intermediate range in the FMR1 gene was not associated with age at natural menopause. Excessive triple ...
Ding Yu Y Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, - - 2013
To identify new candidate therapeutic targets for glioblastoma multiforme, we combined functional genetics and glioblastoma network modeling to identify kinases required for the growth of patient-derived brain tumor-initiating cells (BTIC) but that are dispensable to proliferating human neural stem cells (NSC). This approach yielded BUB1B/BUBR1, a critical mitotic spindle checkpoint ...
Manesh Kalayil Manian - - 2012
A new nanomotor-based surface-patterning technique based on the movement of a magnetically powered enzyme-functionalized flexible nanowire swimmer offers the ability to create complex helical metal microstructures.
Reisinger Kostan W - - 2012
BackgroundReintroduction of enteral nutrition in neonates with necrotizing enterocolitis (NEC) should take place when the gut is ready. Too early start of oral feeding might lead to disease relapse, whereas prolonged discontinuation of enteral nutrition is associated with impaired gut function and parenteral nutrition-related complications. This study evaluates whether non-invasive ...
Fried Marlene Gerber - - 2012
Since the US Supreme Court decision legalizing abortion (Roe v. Wade), there has been a constant and broad attack on all aspects of women's reproductive and parenting rights. The consequences have been devastating, especially for women whose race, age, legal, or economic status makes them targets of discrimination. At the ...
Gasse Christiane - - 2012
Objective: We investigated the association between unipolar depression and incident hospital admissions due to ischemic heart disease, invasive cardiac procedures and mortality independent of other medical illnesses.Methods: A population-based cohort of 4.6 million persons aged 15 years or older and born in Denmark was followed up from 1995-2009. Incidence rate ...
Hidalgo Bertha B Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, AL, USA. - - 2013
The terms multivariate and multivariable are often used interchangeably in the public health literature. However, these terms actually represent 2 very distinct types of analyses. We define the 2 types of analysis and assess the prevalence of use of the statistical term multivariate in a 1-year span of articles published ...
Deng Changchun - - 2012
Brentuximab vedotin (SGN-35), an intravenously administered CD30-specific antibody-drug conjugate, has recently been approved by the U.S. Food and Drug Administration for two indications, including (1) patients with Hodgkin's lymphoma (HL) relapsing after autologous stem cell transplantation (ASCT), or after two multi-drug regimens in HL patients who are not candidates for ...
Alajarín Mateo - - 2012
A number of N-aryl ketenimines, substituted at the ortho position either with different non-cyclic acetalic functions (acetals, monothioacetals, dithioacetals) or with only one alkoxymethyl or (alkylthio)methyl group, have been prepared and submitted to thermal treatment in toluene solution. Under smooth heating the ketenimines bearing non-cyclic acetals converted into 3,4-dihydroquinolines following ...
McLean Natalie - - 2012
Purpose:The aim of this study was to document the range and frequency of ethical dilemmas associated with genetic testing encountered by genetic health professionals and to determine the strategies used to manage them.Methods:An online survey was used to document how often the 11 key ethical dilemmas have been encountered; whether ...
Pham Tài - - 2012
RATIONALE: Many patients with severe acute respiratory distress syndrome (ARDS) caused by influenza A(H1N1) infection received Extracorporeal Membrane Oxygenation (ECMO) as a rescue therapy. OBJECTIVES: To analyze factors associated with death in ECMO-treated patients and the influence of ECMO on ICU mortality. METHODS: Data from patients admitted for (H1N1)-associated ARDS ...
Takabayashi Tetsuji T Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, - - 2013
Nasal polyps (NPs) are characterized by intense edema or formation of pseudocysts filled with plasma proteins, mainly albumin. However, the mechanisms underlying NP retention of plasma proteins in their submucosa remain unclear. We hypothesized that formation of a fibrin mesh retains plasma proteins in NPs. We assessed the fibrin deposition ...
Grandvuillemin Aurélie - - 2012
OBJECTIVES: To compare characteristics of patients exhibiting cetuximab infusion reactions or another adverse drug reaction related to cetuximab and to identify factors associated with the severity of cetuximab infusion reactions. METHODS: All cases of adverse drug reaction reported with cetuximab from 1985 to 2010 were extracted from the French Pharmacovigilance ...
Bennett Simon J - - 2012
The current study examined the effect of inter-ocular delay in a manual aiming task that required accurate end-point placement, but not precise control of a grip aperture. Participants aimed in binocular, monocular, or alternating monocular vision conditions. For the latter, 25ms monocular samples were provided to alternate eyes without delay ...
Ogawa Kotaro - - 2012
1. Focusing on the genetic similarity of CYP3A subfamily enzymes (CYP3A4 and CYP3A5) between monkeys and humans, we have attempted to provide a single-species approach to predicting human hepatic clearance (CL(h)) of CYP3A4 substrates using pharmacokinetic parameters in cynomolgus monkeys following intravenous administrations. 2. Hepatic intrinsic clearance (CL(int,h)) of six ...
Mu Xiaoqin - - 2012
Abstract Oxidative stress has been linked to endothelial dysfunction in atherosclerosis and hypertension. The present study was designed to investigate the effect of hydrogen peroxide (H(2)O(2)) on angiotensin-converting enzyme (ACE), a key regulator of the renin-angiotensin system, and the mechanisms underlying ACE regulation in human umbilical vein endothelial cells (HUVECs). ...
Acampora Dario - - 2012
Mouse embryonic stem cells (ESCs) represent the naïve ground state of the preimplantation epiblast and epiblast stem cells (EpiSCs) represent the primed state of the postimplantation epiblast. Studies have revealed that the ESC state is maintained by a dynamic mechanism characterized by cell-to-cell spontaneous and reversible differences in sensitivity to ...
Leguay Sébastien - - 2012
Complexation of trivalent actinides with DTPA (diethylenetriamine pentaacetic acid) was studied as a function of pcH and temperature in (Na,H)Cl medium of 0.1 M ionic strength. Formation constants of both complexes AnHDTPA(-) and AnDTPA(2-) (where An stands for Am, Cm, and Cf) were determined by TRLFS, CE-ICP-MS, spectrophotometry, and solvent ...
Kupce Eriks - - 2012
We propose a new general form of two-dimensional spectroscopy where the indirect 'evolution' dimension is derived using the Radon transform. This idea is applicable to several types of spectroscopy but is illustrated here for the case of NMR. This 'projection spectroscopy' displays characteristic correlation peaks that highlight perturbations of chemical ...
Ingham Philip W - - 2012
Inspired by a zebrafish mutation, two recent studies by Creanga and colleagues (pp. 1312-1325) and Tukachinsky and colleagues have shed new light on the way in which lipidated Hedgehog proteins are secreted and released from expressing cells, suggesting a model for the sequential action of the Disp and Scube2 proteins ...
Unverfehrt Leonid - - 2012
The new compound LaSr(3)F(5)(CN(2))(2) was prepared and structurally characterized as a prototype structure for the remarkably distorted mixed-valent compound Eu(4)F(5)(CN(2))(2), which contains four distinct europium ions in the structure: one Eu(3+) and three Eu(2+). Instead of repeating the given distorted structural pattern, LaSr(3)F(5)(CN(2))(2) forms a structure which can be considered ...
Martínez-Lillo José - - 2012
Three novel heterobimetallic Re(iv) compounds of formulae [ReBr(4)(μ-ox)M(4,7-Cl(2)phen)(2)]·CH(3)CN·CH(3)NO(2) [M = Co(ii) () and Ni(ii) ()] and [ReBr(4)(ox)](3)[Co(III)(5,6-dmphen)(3)](2)·CH(3)CN·2CH(3)NO(2)·4H(2)O () [ox = oxalate, 4,7-Cl(2)phen = 4,7-dichloro-1,10-phenanthroline and 5,6-dmphen = 5,6-dimethyl-1,10-phenanthroline] have been synthesised and the structures of and determined by single crystal X-ray diffraction. Compound is an oxalato-bridged Re(IV)Co(II) heterodinuclear complex where ...
Langford Linda L Suicide Prevention Resource Center, Education Development Center Inc., Waltham, MA 02453, USA. - - 2013
Concern about suicide in US military and veteran populations has prompted efforts to identify more effective prevention measures. Recent expert panel reports have recommended public communications as one component of a comprehensive effort. Messaging about military and veteran suicide originates from many sources and often does not support suicide prevention ...
Leslie Elizabeth J EJ Department of Pediatrics, University of Iowa, Iowa City, IA, - - 2013
Mutations in the transcription factor IRF6 cause allelic autosomal dominant clefting syndromes, Van der Woude syndrome, and popliteal pterygium syndrome. We compared the distribution of IRF6 coding and splice-site mutations from 549 families with Van der Woude syndrome or popliteal pterygium syndrome with that of variants from the 1000 Genomes ...
Niehl Annette - - 2012
Cell-division-cycle protein 48 (CDC48) is an essential, conserved ATP-driven chaperone in eukaryotic cells, which functions in diverse cellular processes including the targeting of misfolded and aggregated proteins for degradation via proteasomal and aggresomal-autophagic pathways. We recently demonstrated that plant CDC48 localizes to and interacts with Tobacco mosaic virus (TMV) movement ...
Schepers Wim - - 2012
The readdition of an essential nutrient to starved, fermenting cells of the yeast Saccharomyces cerevisiae triggers rapid activation of the protein kinase A (PKA) pathway. Trehalase is activated 5-10-fold within minutes and has been used as a convenient reporter for rapid activation of PKA in vivo. Although trehalase can be ...
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