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Results 601 - 650 of 2118
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Tchankouo-Nguetcheu Stephane - - 2012
ABSTRACT: BACKGROUND: Arthropod-borne viral infections cause several emerging and resurging infectious diseases. Among the diseases caused by arboviruses, chikungunya is responsible for a high level of severe human disease worldwide. The salivary glands of mosquitoes are the last barrier before pathogen transmission. We undertook a proteomic approach to characterize the ...
Abolaji A O - - 2012
Among the artemisinin-based combination therapy (ACT) regimens, artemisinin derivative, artemether in combination with lumefantrine (artemether-lumefantrine, AL) has achieved excellent results in the fight against malarial scourge. In this study, we evaluated the toxic potential of these drugs at the therapeutic doses in female Wistar rats. Animals were randomly divided into ...
Muhammad Riyadh D - - 2012
Background. Certain chronic diseases increase risk for invasive pneumococcal disease (IPD) and are indications for receipt of 23-valent pneumococcal polysaccharide vaccine (PPV23). Since the pediatric introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in 2000, incidence of IPD among adults has declined. The relative magnitude of these indirect effects among persons with ...
Wang Tuo - - 2012
Macrocycles made of cholate building blocks were previously found to transport glucose readily across lipid bilayers. In this study, an 15N, 13Cα-labeled glycine was inserted into a cyclic cholate trimer and attached at the end of a linear trimer, respectively. The isotopic labeling allowed us to use solid-state NMR spectroscopy ...
Nieminen Mikko T MT Research Unit on Acetaldehyde and Cancer, Faculty of Medicine, University of Helsinki, Helsinki, - - 2013
Esophageal cancer is unusually frequent in Western Kenya, despite the low prevalence of classical risk factors such as heavy drinking and tobacco smoking. Among Kenyans consumption of fermented milk is an old tradition. Our hypothesis is that alcohol and acetaldehyde are produced during the fermentation process and that their carcinogenic ...
Kawabe Keiko - - 2012
We have generated a monoclonal antibody (R-10G) specific to human induced pluripotent stem (hiPS)/embryonic stem (hES) cells by using hiPS cells (Tic) as an antigen, followed by differential screening of mouse hybridomas with hiPS and human embryonal carcinoma (hEC) cells. Upon Western blotting with R-10G, human iPS/ES cell lysates gave ...
Ma Kaige - - 2012
Self-assembling peptide nanofiber scaffolds have been studied extensively as biological materials for 3-dimensional cell culture and repairing tissue defects in animals. However, few studies have applied peptide nanofiber scaffolds in the tissue engineering of intervertebral discs (IVDs). In this study, a novel functionalized peptide scaffold was specifically designed for IVD ...
Aoude Lauren G - - 2012
In a seminal study by Harbour and colleagues somatic mutations of BAP1 (BRCA-1 associated protein 1) were found to occur in 84% of metastasizing uveal melanomas (Harbour et al., 2010). Additionally, this study reported one germline mutation. Subsequent studies have shown that germline mutations of BAP1 predispose to uveal and ...
Husband Angus - - 2012
Drewnowski et al.(1) aim to explore the complex relationship between obesity and accessibility of healthy foods on the basis of proximity and price. Their finding that obesity rates were three times higher in those that shopped at low-cost as opposed to high-cost supermarkets persisted even after adjustment for socioeconomic status. ...
Kim Hye-Na - - 2012
This paper describes the use of Nb(2)O(5)-coated TiO(2) 3D ordered porous electrodes in dye-sensitized solar cells. We employed bilayer inverse opal structures as a backbone of 3D porous structures, and the number of Nb(2)O(5) coatings was controlled, determining the concentration of Nb(2)O(5) coating. XPS measurements confirmed the formation of Nb(2)O(5). ...
Watkins Courtney - - 2012
OBJECTIVE: To compare thoracic and abdominal cavity volumes during abdominal CO(2) insufflation and abdominal wall lift (AWL) conditions. STUDY DESIGN: In vitro cadaveric study. ANIMALS: Mature medium-to-large breed fresh canine cadavers (n = 6). METHODS: Each cadaver was imaged with computed tomography (CT) under baseline, abdominal CO(2) insufflation, and AWL ...
Harding Katharine E - - 2012
BACKGROUND: Age of onset of multiple sclerosis (MS) peaks in the 3rd and 4th decades and is rarely less than 18. Robust longitudinal studies in paediatric-onset MS (POMS) are limited, and a clearer understanding of outcome could optimise management strategies. METHODS: Patients with disease onset <18 years were identified from ...
Lurie F - - 2012
PurposeTo assess the variability of interface pressure and changes in this pressure over one month time interval under ready-to-use compression stockings. METHODS: Fifteen healthy volunteers with a broad range of sizes and shapes of the calves were included in final analysis. Each volunteer sequentially used six pairs of stockings daily ...
Cunha Andréa Baraldi - - 2012
The objectives of this study were to verify the influence of a short-duration training session on proximal and distal adjustments at the onset of goal-directed reaching and to verify whether these adjustments change in specificity with the body position trained. Twenty-four infants aged 3-4 months were assessed in supine and ...
Lambiase Alessandro - - 2012
Purpose We aimed to evaluate the NGF pathway and its influence on corneal healing mechanisms in normal conditions and in an animal model of corneal denervation induced by capsaicin. Methods Peripheral sensory damage was induced in rat pups by subcutaneous injection of capsaicin and the effects evaluated by hot-plate test, ...
Kobayashi Tetsuo T Stem Cell Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, - - 2013
Losartan (Los) is a Food and Drug Administration-approved antihypertensive medication that has a well-tolerated side effect profile. We have demonstrated that treatment with Los immediately after injury was effective at promoting muscle healing and inducing an antifibrotic effect in a murine model of skeletal muscle injury. We initially investigated the ...
Tsai Scott S H - - 2012
We describe a technique that measures ultralow interfacial tensions using paramagnetic spheres in a co-flow microfluidic device designed with a magnetic section. Our method involves tuning the distance between the co-flowing interface and the magnet's center, and observing the behavior of the spheres as they approach the liquid-liquid interface-the particles ...
Ho Hsu-Chueh - - 2012
Objective: Acceptable noise level (ANL) determines the maximum noise level that a listener is willing to accept while listening to speech. The objective of this study was to determine the equivalence of ANL measured using different speech stimuli for native speakers who lived in the U.S. and Taiwan. Design: ANLs ...
Tohme Rania A - - 2012
Objectives. We estimated rates and determinants of hepatitis C virus (HCV) testing, infection, and linkage to care among US racial/ethnic minorities. Methods. We analyzed the Racial and Ethnic Approaches to Community Health Across the US Risk Factor Survey conducted in 2009-2010 (n = 53 896 minority adults). Results. Overall, 19% of respondents were ...
Abarin Taraneh - - 2012
Introduction For years, body mass index (BMI) has been used by scientists to track weight problems and obesity in children and adults. Recent studies have implicated the fat mass and obesity gene (FTO) in the increase of BMI in young adults. A longer duration of breastfeeding is known to reduce ...
Donaldson Malcolm - - 2012
Congenital hypothyroidism, usually of the primary and permanent variety, is an eminently preventable cause of growth retardation and mental handicap whose outlook has been transformed by newborn screening, usually involving the measurement of capillary TSH. Severe primary congenital hypothyroidism, due for example to athyreosis, may result in subtle cognitive, behavioural ...
Bonacina Luigi - - 2012
Harmonic nanoparticles were firstly introduced in 2006 as bio-markers for nonlinear imaging. This review provides a general explanation of the physical mechanism at the basis of this novel approach, highlighting its benefits and the complementarity to fluorescent/luminescent labels. A series of application examples from the very recent literature are reported, ...
Webster Jennifer J Center for Health Research, Kaiser Permanente Northwest, Portland, OR 97227, - - 2013
In metastatic colorectal cancer (mCRC), mutations in the KRAS gene predict poor response to EGF receptor (EGFR) inhibitors. Clinical treatment guidelines now recommend KRAS testing if EGFR inhibitors are considered. Our study investigates the clinical uptake and utilization of KRAS testing. We included 1,188 patients with mCRCs diagnosed from 2004 ...
Kanduri Meena M Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg, - - 2012
Chronic lymphocytic leukemia (CLL) can be divided into prognostic subgroups based on the IGHV gene mutational status, and is further characterized by multiple subsets of cases with quasi-identical or stereotyped B cell receptors that also share clinical and biological features. We recently reported differential DNA methylation profiles in IGHV-mutated and ...
Scranton Richard E RE Clinical Scientist Consulting, Framingham, MA 01701, USA. - - 2013
Optimal pharmacologic management of diseases comorbid with erectile dysfunction (ED), such as cardiovascular disease, depression, diabetes, dyslipidemia, hypertension, and benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS), is dependent upon long-term treatment compliance and may be complicated by poor adherence to medication use. ED may contribute to poor adherence to medication ...
Herrero Raquel - - 2012
PURPOSE: To quantify changes in the retinal nerve fiber layer (RNFL) of patients with multiple sclerosis (MS) over 3 years and to evaluate whether treatment protects against RNFL degeneration. Methods: Ninety-four MS patients and 50 healthy subjects were followed-up over 3 years. All subjects underwent a complete ophthalmic examination, which ...
Nguyen Nhung - - 2012
Gastric acid secretion by the H(+)/K(+) ATPase at the apical surface of activated parietal cells requires luminal K(+) provided by the KCNQ1/KCNE2 K(+) channel. However, little is known about the trafficking and relative spatial distribution of KCNQ1 and H(+)/K(+) ATPase in resting and activated parietal cells and the capacity of ...
Avanesov Andrei A Department of Zoology, University of Wisconsin, Madison, WI 53706, - - 2013
Hedgehog (Hh) family proteins are secreted signaling ligands whose short- and long-range activities transform cellular fates in multiple contexts in organisms ranging from metazoans to humans. In the developing Drosophila wing, extracellular Hh binds to cell-bound glypican heparan sulfate proteoglycans (HSPGs) and the secreted protein Shifted (Shf), a member of ...
Dodge Natasha - - 2012
In their recent article Gowda et al. describe a potential pathway by which food insecurity is associated with adverse health outcomes in the US population.(1) By measuring levels of C-reactive protein-a biomarker of inflammation linked to health conditions such as diabetes and cardiovascular disease-the study demonstrates a potential mechanism for ...
Zhang Xin - - 2012
Alkaline-earth metal ions were used to tune four new heterometallic frameworks, {[Cd(2.07)Mg(0.93)(BTC)(2)(H(2)O)(4)]·2H(2)O}(n) (), {[Cd(2)Ca(BTC)(2)(H(2)O)(4)]·2H(2)O}(n) (), {[Cd(2)Sr(BTC)(2)(H(2)O)(5)]·H(2)O}(n) () and [Cd(6)Ba(3)(BTC)(3)(H(2)O)(10)](n) () (H(3)BTC = 1,3,5-benzenetricarboxylic acid), synthesized from H(3)BTC and the corresponding metal salts. Single-crystal X-ray analysis shows that compound is a three-dimensional (3D) framework based on heterometallic Cd-O-Cd-O-Mg inorganic chain subunits, ...
Seay Joseph F - - 2012
We examined the effect of body water deficits on standing balance and sought to determine if plasma hyperosmolality (Posm) and/or volume reduction (%ΔVplasma) exerted independent effects. Nine healthy volunteers completed three experimental trials which consisted of a euhydration (EUH) balance test, a water deficit session and a hypohydration (HYP) balance ...
Gerin Brigitte - - 2012
1. A fast, straightforward and cost-effective assay was validated for the assessment of CYP induction in cryopreserved human hepatocytes cultured in 48-well plates. The cocktail strategy (in situ incubation) was used to assess the induction of CYP1A2, CYP2B6, CYP2C9 and CYP3A4 by using the recommended probe substrate, i.e. phenacetin, bupropion, diclofenac ...
Campbell Sarah - - 2012
The purpose of this study was to determine the prevalence of children's food requests, and parents' experiences of food marketing directed towards children, in the supermarket environment. A mixed-method design was used. Firstly, intercept interviews were conducted with parents accompanied by a child/children on exiting supermarkets (sampled from a large ...
Chartrand Daniel - - 2012
The synthesis and characterization of a novel family of positively charged fac-[Re(bpy)(CO)(3)(L)]PF(6) (bpy = 2,2'-bipyridine) complexes are reported, where L is a pyridine functionalized in para or meta position with a fulvene moiety, namely, 4-fluoren-9-ylidenemethyl-pyridine (pFpy) and 3-fluoren-9-ylidenemethyl-pyridine (mFpy). The complexes were prepared in high yield (86%) by direct addition ...
Halfter Willi W Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA. - - 2013
Basement membranes (BMs) evolved together with the first metazoan species approximately 500 million years ago. Main functions of BMs are stabilizing epithelial cell layers and connecting different types of tissues to functional, multicellular organisms. Mutations of BM proteins from worms to humans are either embryonic lethal or result in severe ...
Nguyen Linh - - 2012
ABSTRACT: BACKGROUND: Treatment of solid tumors with vascular disrupting agent OXi4503 results in over 90% tumor destruction. However, a thin rim of viable cells persists in the tumor periphery following treatment, contributing to subsequent recurrence. This study investigates inherent differences in the microenvironment of the tumor periphery that contribute to ...
Meteyer Carol U - - 2012
White nose syndrome, caused by Geomyces destructans, has killed more than 5 million cave hibernating bats in eastern North America. During hibernation, the lack of inflammatory cell recruitment at the site of fungal infection and erosion is consistent with a temperature-induced inhibition of immune cell trafficking. This immune suppression allows ...
de la Cova Claire - - 2012
The conserved E3 ubiquitin ligase component named SEL-10 in Caenorhabditis elegans and Fbw7 in mammals targets substrates for ubiquitin-mediated degradation through a high-affinity binding site called a Cdc4 phosphodegron (CPD). As many known substrates of Fbw7 are oncoproteins, the identification of new substrates may offer insight into cancer biology as ...
Chen Lichan - - 2012
The preparation, characterization, fluorescence (FL) and electrochemiluminescence (ECL) of graphite-like carbon nitride nanoflake particles (g-C(3)N(4) NFPs) and nanoflake films (g-C(3)N(4) NFFs) have been reported. Highly water-dispersible g-C(3)N(4) NFPs with a height of ∼5 to 35 nm and a lateral dimension of ∼40 to 220 nm have been extracted from bulk ...
McKinney Chad W - - 2012
Disinfection of wastewater treatment plant effluent may be an important barrier for limiting the spread of antibiotic resistant bacteria (ARBs) and antibiotic resistance genes (ARGs). While ideally disinfection should destroy ARGs, in order to prevent horizontal gene transfer to downstream bacteria, little is known about the effect of conventional water ...
Honda Yasushi - - 2012
Excitation spectra of cation and anion radicals of unsaturated hydrocarbons, hexatriene+/-, octatetraene+/-, cyclopentadiene+, 1,3-cyclohexadiene+, and naphthalene+/-, were studied by the symmetry adapted cluster-configuration interaction (SAC-CI) method. The calculated results reasonably reproduced the experimental spectra observed by one of the authors (TS) and gave reasonable assignments. The two bands observed in ...
Bacaksiz Ahmet - - 2013
Psoriasis vulgaris is one of the most common skin disorders. Patients with psoriasis carry an excessive risk of atrial fibrillation (AF). The differences between the maximum (Pmax) and the minimum (Pmin) P-wave duration on ECG are defined as P-wave dispersion (PWD). Prolongation of PWD is an independent risk factor for ...
Furusaka Tohru - - 2012
Abstract Conclusion: Superselective intra-arterial chemotherapy, which enables local control and laryngeal preservation, is a safe and useful therapy for preservation of nutrition, speech, and swallowing functions. Objective: To improve the laryngeal preservation rate in patients with hypopharyngeal piriform sinus squamous cell carcinoma by superselective intra-arterial chemotherapy. Methods: Fifty-seven patients received ...
Xu H-X - - 2012
Purpose: To investigate the imaging features of intrahepatic biliary cystadenoma and cystadenocarcinoma on B-mode and contrast-enhanced ultrasound. Materials and Methods: The B-mode and contrast-enhanced ultrasound features of 6 intrahepatic biliary cystadenomas and 7 intrahepatic biliary cystadenocarcinomas were retrospectively analyzed, and the differences between cystadenomas and cystadenocarcinomas were compared. Results: There ...
Kere Michel M Department of Animal Science, National Chung Hsing University, Taichung 402, Taiwan, - - 2013
In this study, a dose-response assessment was performed to understand the relation between supplementation of media with L-ascorbic acid or vitamin C and porcine oocyte maturation and the in vitro development of parthenotes (PA) and handmade cloned (HMC) embryos. Various concentrations (0, 25, 50 and 100 μg/ml) of vitamin C ...
Luo Guanglin - - 2012
Calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated clinical efficacy in the treatment of acute migraine. Herein, we describe the design, synthesis, and preclinical characterization of a highly potent, oral CGRP receptor antagonist BMS-927711 (8). Compound 8 has good oral bioavailability in rat and cynomolgus monkey, attractive overall preclinical properties, ...
El-Andaloussi Samir S Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, - - 2012
The use of small interfering RNAs (siRNAs) to induce gene silencing has opened a new avenue in drug discovery. However, their therapeutic potential is hampered by inadequate tissue-specific delivery. Exosomes are promising tools for drug delivery across different biological barriers. Here we show how exosomes derived from cultured cells can ...
Kim Sunghee S Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United - - 2012
At -90 °C in acetone, a stable hydroperoxo complex [(BA)Cu(II)OOH](+) (2) (BA, a tetradentate N(4) ligand possessing a pendant -N(H)CH(2)C(6)H(5) group) is generated by reacting [(BA)Cu(II)(CH(3)COCH(3))](2+) with only 1 equiv of H(2)O(2)/Et(3)N. The exceptional stability of 2 is ascribed to internal H-bonding. Species 2 is also generated in a manner ...
Thomsen Mette - - 2012
Background: MARCO (macrophage receptor with collagenous structure) is a dominant receptor for unopsonized particles and bacteria in the lungs. Reduced function of this receptor due to genetic variation may be associated with susceptibility to chronic obstructive pulmonary disease (COPD) and lung infection. Objectives: To identify novel genetic variants in MARCO ...
Raymond J - - 2012
BACKGROUND AND PURPOSE:The relationship between aneurysm dimensions, flow, thrombosis, and rupture remains poorly understood. We attempted to clarify this relationship by exploring various swine aneurysm models.MATERIALS AND METHODS:Bilateral carotid aneurysms were constructed according to 3 protocols in 24 animals: small aneurysms with wide necks (group 1; n = 6 animals); ...
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