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Richardson David B - - 2012
OBJECTIVES: Standardised mortality ratios (SMRs) play an important role in the epidemiological literature, particularly in evaluations of occupational hazards. While some authors have argued that comparisons of SMRs should be avoided, many investigators find such analyses appealing particularly when data are sparse. For example, calendar period-specific SMRs often are examined ...
Nomoto Yuichi - - 2012
In Arabidopsis thaliana, the circadian clock regulates the photoperiodic plant growth including the elongation of hypocotyls in a short-days (SDs)-specific manner. The clock-controlled PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) gene encoding a basic helix-loop-helix (bHLH) transcription factor plays crucial roles in this regulation. The SDs-specific elongation of hypocotyls is best explained by ...
Kruse Holger - - 2012
We analyze the error compensations that are responsible for the relatively good performance of the popular B3LYP/6-31G* model chemistry for molecular thermochemistry. We present the B3LYP-gCP-D3/6-31G* scheme, which corrects for missing London dispersion and basis set superposition error (BSSE) in a physically sound manner. Benchmark results for the general main ...
Jung Kwang Hwa - - 2012
Persistent organic pollutants (POPs) are degradation-resistant anthropogenic chemicals that accumulate in the food chain and in adipose tissue, and are among the most hazardous compounds ever synthesized. However, their toxic mechanisms are still undefined. To investigate whether characteristic molecular signatures can discriminate individual POP and provide prediction markers for the ...
Aguilar-Hidalgo Daniel - - 2012
During development, extracellular signaling molecules interact with intracellular gene networks to control the specification, pattern and size of organs. One such signaling molecule is Hedgehog (Hh). Hh is known to act as a morphogen, instructing different fates depending on the distance to its source. However, how Hh, when signaling across ...
Haley Charlotte L - - 2012
AIMS: Catheter ablation for paroxysmal atrial fibrillation (AF) is rapidly becoming a standard practice. There is literature to support that catheter ablation of persistent AF requires additional 'substrate modification'. In clinical practice, operators rely on automated fractionation maps created by three-dimensional anatomic mapping systems to rapidly assess complex 'fractionated' signals ...
Abdelhafez Omaima M - - 2012
New series of 4-methyl and 3,4-dimethyl-7-oxycoumarin derivatives (oxadiazoles, thiadiazoles, triazoles and thiazolidinones) were designed, synthesized and evaluated for their monoamine oxidase (MAO) A and B inhibiting effect. All the synthesized compounds showed in vitro high affinity and selectivity towards MAO-A isoenzyme, compared to clorgyline and moclobemide, with Ki values on ...
Niihori Yoshiki - - 2012
The effect of Pd doping on the ligand-exchange reactivity of Au(25)(SC(12)H(25))(18) was studied by comparing the ligand-exchange reactivity of [Au(25)(SC(12)H(25))(18)](-) and [PdAu(24)(SC(12)H(25))(18)](0) and the results clearly demonstrate that, regardless of the kind of incoming thiols and solvents, Pd doping greatly increases the rate of ligand exchange of Au(25)(SC(12)H(25))(18), indicating an ...
Yarkoni Orr - - 2012
Manipulation of signal transduction pathways presents a viable mechanism to interface cells with electronics. In this work, we present a two-step signal transduction pathway involving cellular and electronic transduction elements. In order to circumvent many of the conventional difficulties encountered when harnessing chemical signalling for the purpose of electronics communication, ...
Bosco Laura - - 2012
Coma-induced blisters is a rare condition associated with prolonged impairment of conscious level, which is relatively well-known in adults following overdose with barbiturates. However, it has been very rarely described in children. A case of coma-bullae occurring in an 11-year-old child with meningoencephalitis is herein reported. The bullous lesions occurred ...
Bradford Judith - - 2012
Objectives. We examined relationships between social determinants of health and experiences of transgender-related discrimination reported by transgender people in Virginia. Methods. In 2005 through 2006, 387 self-identified transgender people completed a statewide health needs assessment; 350 who completed eligibility questions were included in this examination of factors associated with experiences ...
Lin Xionghao - - 2012
Terpecurcumins A-I (1-9), together with three known analogues (10-12), were isolated from the rhizomes of Curcuma longa (turmeric). They were derived from the hybridization of curcuminoids and bisabolanes. The structures and absolute configurations of 1-9 were elucidated on the basis of extensive spectroscopic data analysis, including NMR and electronic circular ...
Stegemann-Koniszewski Sabine - - 2012
Increased risk for bacterial superinfections substantially contributes to the mortality caused by influenza A virus (IAV) epidemics. While the mechanistic basis for this lethal synergism is still insufficiently understood, immune modulation through the viral infection has been shown to be involved. Since the pattern-recognition receptor (PRR) toll-like receptor 7 (TLR7) ...
Podberezin Mark - - 2012
Context.-Cancer stem cells (CSCs) comprise a minor cell population in a tumor; however, they possess self-renewal capacity and are responsible for tumor recurrence and the emerging issue of tumor resistance. Despite recent advances in the study of pathogenesis and mechanisms of CSC-mediated disease recurrence and multidrug resistance, many questions remain ...
Zerweck Christof - - 2012
BACKGROUND: Endovenous Laser Ablation (EVLA) is one of the most accepted treatment options for varicose veins. The aim of this study was to investigate the efficacy and safety of the new radial fiber slim (ELVeS-radial-slim kit(TM)) for the 1470 nm diode laser in perforator veins with a 1 month follow-up. ...
Porta Camillo - - 2012
Objectives: This study included a cohort of advanced renal cell carcinoma patients treated with sunitinib. Since resistance to sunitinib may be mediated through angiogenic cytokines other than VEGF, we measured the circulating levels of three pro-angiogenic cytokines: basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and interleukin (IL)-6. Methods: ...
Slagt Cornelis - - 2012
To evaluate the 3.02 software version of the FloTrac/Vigileo™ system for estimation of cardiac output by uncalibrated arterial pressure waveform analysis, in septic shock. Nineteen consecutive patients in septic shock were studied. FloTrac/Vigileo™ measurements (COfv) were compared with pulmonary artery catheter thermodilution-derived cardiac output (COtd). The mean cardiac output was ...
Kadom N - - 2012
SUMMARY:Failure to detect FCD and similar lesions encountered in patients with tuberous sclerosis can have significant clinical consequences, such as preventing surgical intervention for medically refractory epilepsy and misguiding prognostic information regarding cognitive development. Here, we show the beneficial effects on detection of FCD and cortical tubers when using a ...
Hatta Taku - - 2012
Abstract Background. Shoulder external rotation braces used for patients with a first-time shoulder dislocation are designed with a variety of arm positions in abduction as well as external rotation. However, few studies have focused on their immobilizing performance, comfort, or user-friendliness. Especially, there have been no robust data of shoulder ...
Elkobi-Peer Shira - - 2012
Five new natural products, aeruginosins GE686 (1), GE766 (2), GE730 (3), GE810 (4), and GE642 (5), were isolated along with four known aeruginosins, 98C, 101, KY642, and DA688, from bloom material of the cyanobacterium Microcystis aeruginosa collected from a fish pond in Kibbutz Geva, Israel, in August 2007. Their structures ...
Versfeld Niek J - - 2012
Objective: A common method to assess the functional benefit of hearing aids is by measuring the performance-intensity curve of single words in quiet with and without hearing aids. Currently, virtually all hearing aids use signal processing, which may have a marked effect on gain as a function of time. Thus, ...
Sawosz P - - 2012
A time-gated intensified CCD camera was applied for time-resolved imaging of light penetrating in an optically turbid medium. Spatial distributions of light penetration probability in the plane perpendicular to the axes of the source and the detector were determined at different source positions. Furthermore, visiting probability profiles of diffuse reflectance ...
Brown Rosalind S - - 2012
Autoimmune thyroiditis (AIT) is the most common thyroid disorder in the pediatric age range. The disease results from an as yet poorly characterized defect or defects in immunoregulation and a cascade of events progressing from lymphocyte infiltration of the thyroid, to T-cell- and cytokine-mediated thyroid follicular cell injury, and apoptotic ...
Karam Allan - - 2012
Lentigo maligna is an intra-epidermic melanoma that occurs on sun-exposed skin. The gold standard treatment for these lesions is surgery. However, surgery is sometimes difficult because lentigo maligna is frequently widespread. Furthermore, esthetic and functional reconstruction is often difficult because of the location of lesions on the face and the ...
Costa Dolors - - 2012
Significant progress in the understanding of the genetic basis of acute myeloid leukemia (AML) has been made during the last 30 years. The aim of the present study was to assess whether the detection of recurrent gene rearrangements by fluorescent in situ hybridization (FISH) studies and NPM1 and FLT3 gene ...
Miller Ashley E M - - 2012
Iodine has many important biological functions and its concentrations vary with environment. Recent research has provided novel insights into iodine uptake mechanisms in marine bacteria and kelp through hydrogen peroxide dependent diffusion (PDD). This mechanism is distinct from sodium dependent mechanisms known from vertebrates. In vertebrates, iodine accumulates in the ...
Sakeye Motolani - - 2012
Amino-modified metal oxide materials are essential in a wide range of applications, including chromatography, ion adsorption, and as biomaterials. The aim of this study is to compare different functionalization techniques on a selection of metal oxides (i.e. SiO2, TiO2, ZrO2, and SnO2) in order to determine which combination has the ...
Palonen Eveliina - - 2012
Abstract Yersinia pseudotuberculosis is a foodborne pathogen often detected and identified using polymerase chain reaction (PCR) with primers targeted to virulence genes. Sequence variability of the virulence genes in strains representing different serotypes is unknown. Sequence variability could hinder the recognition of this pathogen by PCR and affect the host-pathogen ...
George Jyothis T - - 2012
RATIONALE: Low serum testosterone is commonly observed in men with type 2 diabetes (T2DM) but the neuroendocrine pathophysiology remains to be elucidated. OBJECTIVES: The hypothalamic neuropeptide kisspeptin integrates metabolic signals with the reproductive axis in animal models. We hypothesised that administration of exogenous kisspeptin-10 will restore luteinising hormone (LH) and ...
Aoude Lauren G - - 2012
In a seminal study by Harbour and colleagues somatic mutations of BAP1 (BRCA-1 associated protein 1) were found to occur in 84% of metastasizing uveal melanomas (Harbour et al., 2010). Additionally, this study reported one germline mutation. Subsequent studies have shown that germline mutations of BAP1 predispose to uveal and ...
Husband Angus - - 2012
Drewnowski et al.(1) aim to explore the complex relationship between obesity and accessibility of healthy foods on the basis of proximity and price. Their finding that obesity rates were three times higher in those that shopped at low-cost as opposed to high-cost supermarkets persisted even after adjustment for socioeconomic status. ...
Kim Hye-Na - - 2012
This paper describes the use of Nb(2)O(5)-coated TiO(2) 3D ordered porous electrodes in dye-sensitized solar cells. We employed bilayer inverse opal structures as a backbone of 3D porous structures, and the number of Nb(2)O(5) coatings was controlled, determining the concentration of Nb(2)O(5) coating. XPS measurements confirmed the formation of Nb(2)O(5). ...
Watkins Courtney - - 2012
OBJECTIVE: To compare thoracic and abdominal cavity volumes during abdominal CO(2) insufflation and abdominal wall lift (AWL) conditions. STUDY DESIGN: In vitro cadaveric study. ANIMALS: Mature medium-to-large breed fresh canine cadavers (n = 6). METHODS: Each cadaver was imaged with computed tomography (CT) under baseline, abdominal CO(2) insufflation, and AWL ...
Harding Katharine E - - 2012
BACKGROUND: Age of onset of multiple sclerosis (MS) peaks in the 3rd and 4th decades and is rarely less than 18. Robust longitudinal studies in paediatric-onset MS (POMS) are limited, and a clearer understanding of outcome could optimise management strategies. METHODS: Patients with disease onset <18 years were identified from ...
Lurie F - - 2012
PurposeTo assess the variability of interface pressure and changes in this pressure over one month time interval under ready-to-use compression stockings. METHODS: Fifteen healthy volunteers with a broad range of sizes and shapes of the calves were included in final analysis. Each volunteer sequentially used six pairs of stockings daily ...
Cunha Andréa Baraldi - - 2012
The objectives of this study were to verify the influence of a short-duration training session on proximal and distal adjustments at the onset of goal-directed reaching and to verify whether these adjustments change in specificity with the body position trained. Twenty-four infants aged 3-4 months were assessed in supine and ...
Lambiase Alessandro - - 2012
Purpose We aimed to evaluate the NGF pathway and its influence on corneal healing mechanisms in normal conditions and in an animal model of corneal denervation induced by capsaicin. Methods Peripheral sensory damage was induced in rat pups by subcutaneous injection of capsaicin and the effects evaluated by hot-plate test, ...
Tsai Scott S H - - 2012
We describe a technique that measures ultralow interfacial tensions using paramagnetic spheres in a co-flow microfluidic device designed with a magnetic section. Our method involves tuning the distance between the co-flowing interface and the magnet's center, and observing the behavior of the spheres as they approach the liquid-liquid interface-the particles ...
Ho Hsu-Chueh - - 2012
Objective: Acceptable noise level (ANL) determines the maximum noise level that a listener is willing to accept while listening to speech. The objective of this study was to determine the equivalence of ANL measured using different speech stimuli for native speakers who lived in the U.S. and Taiwan. Design: ANLs ...
Tohme Rania A - - 2012
Objectives. We estimated rates and determinants of hepatitis C virus (HCV) testing, infection, and linkage to care among US racial/ethnic minorities. Methods. We analyzed the Racial and Ethnic Approaches to Community Health Across the US Risk Factor Survey conducted in 2009-2010 (n = 53 896 minority adults). Results. Overall, 19% of respondents were ...
Abarin Taraneh - - 2012
Introduction For years, body mass index (BMI) has been used by scientists to track weight problems and obesity in children and adults. Recent studies have implicated the fat mass and obesity gene (FTO) in the increase of BMI in young adults. A longer duration of breastfeeding is known to reduce ...
Donaldson Malcolm - - 2012
Congenital hypothyroidism, usually of the primary and permanent variety, is an eminently preventable cause of growth retardation and mental handicap whose outlook has been transformed by newborn screening, usually involving the measurement of capillary TSH. Severe primary congenital hypothyroidism, due for example to athyreosis, may result in subtle cognitive, behavioural ...
Bonacina Luigi - - 2012
Harmonic nanoparticles were firstly introduced in 2006 as bio-markers for nonlinear imaging. This review provides a general explanation of the physical mechanism at the basis of this novel approach, highlighting its benefits and the complementarity to fluorescent/luminescent labels. A series of application examples from the very recent literature are reported, ...
Herrero Raquel - - 2012
PURPOSE: To quantify changes in the retinal nerve fiber layer (RNFL) of patients with multiple sclerosis (MS) over 3 years and to evaluate whether treatment protects against RNFL degeneration. Methods: Ninety-four MS patients and 50 healthy subjects were followed-up over 3 years. All subjects underwent a complete ophthalmic examination, which ...
Nguyen Nhung - - 2012
Gastric acid secretion by the H(+)/K(+) ATPase at the apical surface of activated parietal cells requires luminal K(+) provided by the KCNQ1/KCNE2 K(+) channel. However, little is known about the trafficking and relative spatial distribution of KCNQ1 and H(+)/K(+) ATPase in resting and activated parietal cells and the capacity of ...
Mahle Gray Kristen - - 2012
Objectives. To report on indicators of the National HIV/AIDS Strategy, we analyzed data collected through the national HIV surveillance system. Methods. We analyzed data from adults and adolescents aged 13 years or older diagnosed with HIV in 13 US jurisdictions that have laboratory reporting of CD4+ T-lymphocyte (CD4) and viral ...
Capurso Daniel - - 2012
ABSTRACT: BACKGROUND: Applying supervised learning/classification techniques to epigenomic data may reveal properties that differentiate histone modifications. Previous analyses sought to classify nucleosomes containing histone H2A/H4 arginine 3 symmetric dimethylation (H2A/H4R3me2s) or H2A.Z using human CD4+ T-cell chromatin immunoprecipitation sequencing (ChIP-Seq) data. However, these efforts only achieved modest accuracy with limited ...
Bonnet Xavier - - 2012
The lack of shelter can perturb behaviors, increase stress level, and thus alter physiological performances (e.g. digestive, immune, or reproductive functions). Although intuitive, such potential impacts of lack of shelter remain poorly documented. We manipulated shelter availability, environmental and physiological variables (i.e. access to a heat source, predator attack, feeding ...
Filella Xavier - - 2012
Abstract The usefulness of %[-2] proPSA and Prostate Health Index (phi) in the detection of prostate cancer are currently unknown. It has been suggested that these tests can distinguish prostate cancer from benign prostatic diseases better than PSA or %fPSA. We performed a systematic review and meta-analysis of the available ...
Elder Todd E - - 2012
Several recent studies suggest that individual subjective survival forecasts are powerful predictors of both mortality and behavior. Using 15 years of longitudinal data from the Health and Retirement Study, I present an alternative view. Across a wide range of ages, predictions of in-sample mortality rates based on subjective forecasts are substantially ...
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