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Results 551 - 600 of 2119
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Xu Juan - - 2012
MicroRNAs (miRNAs), as master gene regulators, control various cellular processes through the post-transcriptional regulatory network. miRNA synergetic regulations are gradually identified by experimental or computational evidence. However, the potential characteristic underlying miRNA synergism remains a mystery. Based on the constructed miRNA-miRNA functional synergetic networks (MFSNs), we attempted to systematically dissect ...
Thomsen Mette - - 2012
Background: MARCO (macrophage receptor with collagenous structure) is a dominant receptor for unopsonized particles and bacteria in the lungs. Reduced function of this receptor due to genetic variation may be associated with susceptibility to chronic obstructive pulmonary disease (COPD) and lung infection. Objectives: To identify novel genetic variants in MARCO ...
Raymond J - - 2012
BACKGROUND AND PURPOSE:The relationship between aneurysm dimensions, flow, thrombosis, and rupture remains poorly understood. We attempted to clarify this relationship by exploring various swine aneurysm models.MATERIALS AND METHODS:Bilateral carotid aneurysms were constructed according to 3 protocols in 24 animals: small aneurysms with wide necks (group 1; n = 6 animals); ...
Hu Yuandu - - 2012
Soft photonic crystals (PC) are more appealing due to the responsiveness of the building blocking-deformable nanoparticles to the external stimuli. In this report, we demonstrate, for the first time, the generation of soft core/shell PC microspheres through a combination of a microfluidic technique, encapsulation of well-ordered temperature responsive polymer nanogels ...
SzymaƄski P - - 2012
The aim of this study was to synthesize and determine the biological activity of new deri-vatives of 4-fluorobenzoic acid and tetrahydroacridine towards inhibition of cholinesterases. Compounds were synthesized in condensation reaction between 9-aminoalkyl-tetrahydroacri-dines and the activated 4-fluorobenzoic acid. Properties towards inhibition of acetyl- and butyrylcholinesterase were estimated according to Ellman's ...
Wonderlich Elizabeth R - - 2012
Dendritic cells (DC) are a heterogeneous population of innate immune cells that are fundamental to initiating responses against invading pathogens and regulating immune responses. Myeloid DC (mDC) act as a bridge between the innate and adaptive immune response during virus infections but their role in immunity to human immunodeficiency virus ...
Lu Jinzhen - - 2012
Careful control of the reaction stoichiometry and conditions enables the synthesis of both LiTCNQF(4) and Li(2)TCNQF(4) to be achieved. Reaction of LiI with TCNQF(4), in a 4:1 molar ratio, in boiling acetonitrile yields Li(2)TCNQF(4). However, deviation from this ratio or the reaction temperature gives either LiTCNQF(4) or a mixture of ...
Nelson Christian J - - 2012
Introduction.  Peyronie's disease (PD) is characterized by an accumulation of scar tissue in the tunica albuginea of the penis that causes curvature and deformity. PD can result in psychological distress, depression, or anxiety, which often goes untreated. Aims.  To review the current literature on the psychological impact of PD, educate ...
Alemán José - - 2012
In the last decade, organocatalysis, the use of small chiral organic molecules as catalysts, has proven to be a valuable and attractive tool for the synthesis of enantiomerically enriched molecules. A number of organocatalysts and processes, such as one-pot, tandem, cascade or multicomponent reactions, have been reported to date. Furthermore, ...
Chalot Michel - - 2012
We investigated the fate of trace elements (TE) in poplar wood on the conversion of biomass to heat in a 0.2 MW combustion unit equipped with a fabric filter. The phytoremediation wood was harvested from a TE-contaminated agricultural site planted with a high-density poplar stand. The combustion technology used in ...
Jeong Shin Young - - 2012
Background Chronic sialadenitis is one of the most frequent chronic complications after radioiodine (RAI) therapy for thyroid cancer. To evaluate the long-term effects of RAI ablation on salivary gland function, we investigated scintigraphic changes in salivary glands by direct comparison of two salivary gland scintigraphies (SGS) taken before and at ...
Dougherty Max - - 2012
Development of the palate in vertebrates involves cranial neural crest migration, convergence of facial prominences and extension of the cartilaginous framework. Dysregulation of palatogenesis results in orofacial clefts, which represent the most common structural birth defects. Detailed analysis of zebrafish palatogenesis revealed distinct mechanisms of palatal morphogenesis: extension, proliferation and ...
Yue C S - - 2012
To better understand the pharmacokinetics and potential advantages of a levothyroxine oral solution vs. tablets and soft gel capsules.4 randomized, 2-treatment, single-dose (600 mcg levothyroxine), 2-way crossover bioequivalence studies in 84 healthy subjects were analyzed. Samples were collected before dosing and until 48-72 h post-dose to calculate noncompartmental baseline-adjusted pharmacokinetic parameters: ...
Bolaño Tamara - - 2012
The facile and high-yield reaction between aniline and cis-positioned nitriles of [((t)bpy)(2)Rh(NCR)(2)][OTf](3) [R = Me (), Ph (); (t)bpy = 4,4'-di-tert-butyl-2,2'-bipyridine; OTf = CF(3)SO(3)(-)] produces the Rh(III)-triazapentadiene species [((t)bpy)(2)[upper bond 1 start]Rh{NH[double bond, length as m-dash]C(R)N(Ph)C(R)[double bond, length as m-dash]N[upper bond 1 end]H}][OTf](3) [R = Me (), Ph ()]. It ...
Chen Song - - 2012
BACKGROUND: The aim of the present study was to assess the association between M235T polymorphism and heart failure using a meta-analysis. METHODS: A literature search of Google Scholar, PubMed, the Cochrane Library and the China National Knowledge Infrastructure database (January 1990-April 2012) was performed for relevant studies. Statistical analyses were ...
Ding Guodong - - 2012
Significant amounts of pyrethroid pesticides are used throughout China. Previous studies have suggested that exposure to pesticides may increase the risk of childhood cancer; however, few studies have focused on pyrethroid metabolites. We investigated five non-specific metabolites of pyrethroid pesticides found in children's urine and examined the correlation with childhood ...
Gautier Mathieu - - 2012
The recent development of high throughput genotyping technologies has revolutionized the collection of data in a wide range of both model and non-model species. These data generally contain huge amounts of information about the past demographic history of populations.In this study we introduce a new method to estimate divergence times ...
Corrales Teresa - - 2012
A triblock copolymer based on poly(ε-caprolactone) (PCL) and 2-(N,N-diethylamino)ethyl methacrylate (DEAEMA)/2-(methyl-7-nitrobenzofurazan)amino ethyl acrylate (NBD-NAcri), was synthesized via atom transfer radical polymerization (ATRP). The corresponding chlorohydrated copolymer, named as PCL-b-DEAEMA, was prepared and anchored via cationic exchange on montmorillonite (MMT) surface. (PCL)/layered silicate nanocomposites were prepared through melt intercalation, and XRD ...
Oliveira Daniela Cristina de - - 2012
Abstract Purpose: This longitudinal clinic study evaluated the effect of a glass ionomer sealant (GIS) and a fluoride varnish (FV) in the prevention of dental decay on newly erupted permanent molars of children with and without caries experience. Materials and methods: Eighty children, aged 6-8 years, with all four newly ...
Cui Xiao - - 2012
ABSTRACT: BACKGROUND: Male reproduction is an essential biological event in the plant life cycle separating the diploid sporophyte and haploid gametophyte generations, which involves expression of approximately 20,000 genes. The control of male reproduction is also of economic importance for plant breeding and hybrid seed production. With the advent of ...
Bao Bo - - 2012
Monitoring of sequestered carbon is essential to establishing the environmental safety and the efficacy of geological carbon sequestration. Sequestration in saline aquifers requires the detection of supercritical CO2 and CO2-saturated brine as distinct from the native reservoir brine. Here we demonstrate an all-optical approach to detect both supercritical CO2, and ...
Yasuda Takashi - - 2012
Suppression of the renin-angiotensin system is known to slow progression of chronic kidney disease (CKD). However, few trials have been performed with Japanese patients. This study investigated whether the angiotensin receptor blocker (ARB) valsartan would delay the progression of kidney disease more effectively than conventional treatment in Japanese hypertensive patients ...
Lupattelli T - - 2012
Chronic cerebrospinal venous insufficiency (CCSVI) is a syndrome characterized by stenoses of the internal jugular veins (IJVs) and/or azygos veins and formation of collateral venous channels. A case of a 57-year-old patient with CCSVI in whom the venous outflow from the left IJV to the right atrium occurred through a ...
Hashimoto Sayuki - - 2012
Aim: To investigate the acute effects of postprandial exercise on glucose and lipoprotein metabolism after the intake of glucose with or without fat cream in healthy but sedentary young women.Methods: Healthy young Japanese women with a sedentary lifestyle, normal weight (18.5≤BMI<25), normal ovarian cycle, and apolipoprotein (apo) E3/3 were enrolled ...
Chakraborty K - - 2012
Chronic myeloid leukemia is characterized by a unique reciprocal translocation between chromosomes 9 and 22 resulting in deregulated tyrosine kinase activity. Tyrosine kinase inhibitors, such as imatinib, dasatinib, and nilotinib have revolutionized treatment of Chronic myeloid leukemia. However, tyrosine kinase inhibitors' use has presented new challenges in managing both acute ...
Kim Bo Heum - - 2012
Liquid-sucking phenomena by the two-pump system of a female mosquito have been investigated experimentally to understand the feeding mechanism. In most previous experimental studies on liquid-feeding insects, the net increase of mass was divided by the feeding time and fluid density to evaluate the intake rate. However, this weighting method ...
Lulli Matteo - - 2012
Purpose. To evaluate if coenzyme Q10 (CoQ10) can protect retinal ganglion cells (RGCs) from apoptosis and, when instilled as eye drops on the cornea, if it can reach the retina and exert its antiapoptotic activity in this area in a mouse model of kainate (KA)-induced retinal damage. Methods. Rat primary ...
Asaoka Ryo - - 2012
PURPOSE: To infer the combination of visual field (VF) test points, taken from a newly created visual field test grid centred at the optic disc (disc-centred field; DCF) and the conventional fovea-centred 24-2 grid (24-2) of standard automated perimetry (SAP), which yields the strongest structure-function relationship indicated by the correlation ...
Ródenas Sergio - - 2012
OBJECTIVE: To report the clinical, imaging, pathologic findings, surgical planning, and long-term outcome after surgery in a dog with neurologic deficits because of a hypertrophic ganglioneuritis that compressed the spinal cord. STUDY DESIGN: Clinical report. ANIMAL: An 8-year-old male intact Yorkshire terrier. METHODS: The dog had ambulatory tetraparesis and neurologic ...
Escalante Andrea M - - 2012
Sequential activation of different reversible exchange reactions in a dynamic combinatorial library allows directed exploration of the chemical space: initially a macrocyclic scaffold is selected by the template and finally side chain and conformational constrains are introduced into such a scaffold.
Chen Lichan - - 2012
The preparation, characterization, fluorescence (FL) and electrochemiluminescence (ECL) of graphite-like carbon nitride nanoflake particles (g-C(3)N(4) NFPs) and nanoflake films (g-C(3)N(4) NFFs) have been reported. Highly water-dispersible g-C(3)N(4) NFPs with a height of ∼5 to 35 nm and a lateral dimension of ∼40 to 220 nm have been extracted from bulk ...
McKinney Chad W - - 2012
Disinfection of wastewater treatment plant effluent may be an important barrier for limiting the spread of antibiotic resistant bacteria (ARBs) and antibiotic resistance genes (ARGs). While ideally disinfection should destroy ARGs, in order to prevent horizontal gene transfer to downstream bacteria, little is known about the effect of conventional water ...
Honda Yasushi - - 2012
Excitation spectra of cation and anion radicals of unsaturated hydrocarbons, hexatriene+/-, octatetraene+/-, cyclopentadiene+, 1,3-cyclohexadiene+, and naphthalene+/-, were studied by the symmetry adapted cluster-configuration interaction (SAC-CI) method. The calculated results reasonably reproduced the experimental spectra observed by one of the authors (TS) and gave reasonable assignments. The two bands observed in ...
Furusaka Tohru - - 2012
Abstract Conclusion: Superselective intra-arterial chemotherapy, which enables local control and laryngeal preservation, is a safe and useful therapy for preservation of nutrition, speech, and swallowing functions. Objective: To improve the laryngeal preservation rate in patients with hypopharyngeal piriform sinus squamous cell carcinoma by superselective intra-arterial chemotherapy. Methods: Fifty-seven patients received ...
Xu H-X - - 2012
Purpose: To investigate the imaging features of intrahepatic biliary cystadenoma and cystadenocarcinoma on B-mode and contrast-enhanced ultrasound. Materials and Methods: The B-mode and contrast-enhanced ultrasound features of 6 intrahepatic biliary cystadenomas and 7 intrahepatic biliary cystadenocarcinomas were retrospectively analyzed, and the differences between cystadenomas and cystadenocarcinomas were compared. Results: There ...
Luo Guanglin - - 2012
Calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated clinical efficacy in the treatment of acute migraine. Herein, we describe the design, synthesis, and preclinical characterization of a highly potent, oral CGRP receptor antagonist BMS-927711 (8). Compound 8 has good oral bioavailability in rat and cynomolgus monkey, attractive overall preclinical properties, ...
Okonogi Siriporn - - 2012
Context: The number of patients with cancer is increasing. New therapeutic agents to overcome drug-resistant tumors are urgently needed. Cyrtosperma johnstonii N.E. Br. (Araceae) is used for treatment of cancer in Thai traditional medicine. This study aimed to evaluate antioxidant activity and cytotoxicity of C. johnstonii extracts on human cancer ...
Curtin W M - - 2012
Objective:Uniform histopathologic guidelines were applied to diagnose chorioamnionitis and estimate the accuracy of clinical signs in term parturients.Study Design:A retrospective cohort study utilized slides from term parturient placentas with Amniotic Fluid Infection Nosology Committee guidelines as the gold standard. Sensitivity, specificity and accuracy for fever, maternal tachycardia and fetal tachycardia ...
Wang Jiahong - - 2012
Erythropoietin (EPO) has been used for the management of renal anemia. Recent studies suggest the pleiotropic properties of EPO in various tissues such as brain, kidney and vasculature. Diabetes mellitus is a major risk for development of vascular impairment. The aim of the present study was to investigate the hypothesis ...
Smith Kyle Warren - - 2012
Sulfite reductase catalyzes the six-electron reduction of sulfite to sulfide. The active site, found in the hemoprotein subunit (SiRHP), sits on the distal face of a negatively charged porphyrinoid called siroheme whose central iron atom is coupled to a proximal Fe4S4 cluster. Four positively charged amino acids are positioned around ...
Bhosale Prasad S - - 2012
Bridge flocculated colloidal gels are used in many important processes and products such as gel casting for advanced ceramics, precursor inks for 3D printing and waste treatment strategies. An important aspect of polymer bridged gels that makes them excellent candidates for these applications is the precise control it affords for ...
Eichenbaum Zehava - - 2012
The β-hemolytic group A streptococcus (GAS) is a major pathogen that readily uses hemoglobin to satisfy its requirements for iron. The streptococcal hemoprotein receptor in GAS plays a central role in heme utilization and binds fibronectin and laminin in vitro. Shr inactivation attenuates the virulent M1T1 GAS strain in two ...
Tanabe J - - 2012
BACKGROUND AND PURPOSE:Frontolimbic circuits are involved in learning and decision-making processes thought to be affected in substance-dependent individuals. We investigated frontolimbic cortical morphometry in substance-dependent men and women and determined whether morphometric measurements correlated with decision-making performance.MATERIALS AND METHODS:Twenty-eight abstinent SDI (17 men/11 women) were compared with 28 controls (13 ...
Murase Kenya - - 2012
We present a simple method for calculating the magnetization in spin-locking (SL) magnetic resonance imaging (MRI), in which a simple matrix equation was derived for solving the time-dependent Bloch equations in the 2-pool chemical exchange model. We also present a method for visualizing the trajectory of a magnetization vector in ...
Allam S - - 2012
Previous volunteer studies of an effect-site controlled, patient-maintained sedation system using propofol have demonstrated a risk of over-sedation. We have incorporated a reaction-time monitor into the handset of the patient-maintained sedation system to add an individualised patient-feedback mechanism. This study assessed if such reaction-time feedback modification would reduce the risk ...
Curti Alessandra - - 2012
Abstract Objectives: To evaluate whether transvaginal ultrasound cervical length (TVU CL) can predict antepartum bleeding (APB) in women with low-lying placenta. Study design: A retrospective study was performed including pregnancies with low-lying placenta for which third trimester TVU CL was available. Multiple pregnancies were excluded. Short cervix was defined as ...
Muraoka Satoshi - - 2012
The Chromosome-centric Human Proteome Project (C-HPP) aims to define all proteins encoded in each chromosome and especially to identify proteins that currently lack evidence by mass spectrometry. The C-HPP also prioritizes particular protein subsets such as membrane proteins, post-translational modifications, and low-abundance proteins. In this study, we aimed to generate ...
Briyal S - - 2012
The effect of repeated administration of centhaquin to pregnant rats on postnatal development, and expression of ETA and ETB receptors was determined. Pregnant rats were treated daily with either saline or centhaquin for 2 weeks. Male rat pups were sacrificed on day 1, 7, 14 and 28 of birth. Brain, ...
Han Tian - - 2012
Four binuclear dysprosium compounds incorporating the radical ligand 2-(4-oxidopyridyl)-4,4,5,5-tetramethylimidazolin-1-oxyl-3-oxide (PyNONIT) have been successfully synthesized under appropriate conditions. Centrosymmetric bimetallic Dy(2)O(2) cores in all of the compounds through double-μ(2)-oxygen atoms of the N-oxide groups are realized in a metal-radical approach for the first time. Dimers 1 and 2, of the same ...
Kandambeth Sharath - - 2012
Two new chemically stable [acid and base] 2-D crystaline COFs (TpPa-1 and -2) were synthesized using combined reversible and irreversible organic reaction. Synthesis of COFs were done by the Schiff base reaction between Triformylphloroglucinol (Tp) and paraphenylenediamine (Pa-1) or 2, 5-dimethyl-paraphenylenediamine (Pa-2) in mesitylene dioxane 1: 1 combination. The expected ...
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