Search Results
Results 501 - 550 of 2119
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Leguay Sébastien - - 2012
Complexation of trivalent actinides with DTPA (diethylenetriamine pentaacetic acid) was studied as a function of pcH and temperature in (Na,H)Cl medium of 0.1 M ionic strength. Formation constants of both complexes AnHDTPA(-) and AnDTPA(2-) (where An stands for Am, Cm, and Cf) were determined by TRLFS, CE-ICP-MS, spectrophotometry, and solvent ...
Kupce Eriks - - 2012
We propose a new general form of two-dimensional spectroscopy where the indirect 'evolution' dimension is derived using the Radon transform. This idea is applicable to several types of spectroscopy but is illustrated here for the case of NMR. This 'projection spectroscopy' displays characteristic correlation peaks that highlight perturbations of chemical ...
Dodge Natasha - - 2012
In their recent article Gowda et al. describe a potential pathway by which food insecurity is associated with adverse health outcomes in the US population.(1) By measuring levels of C-reactive protein-a biomarker of inflammation linked to health conditions such as diabetes and cardiovascular disease-the study demonstrates a potential mechanism for ...
Zhang Xin - - 2012
Alkaline-earth metal ions were used to tune four new heterometallic frameworks, {[Cd(2.07)Mg(0.93)(BTC)(2)(H(2)O)(4)]·2H(2)O}(n) (), {[Cd(2)Ca(BTC)(2)(H(2)O)(4)]·2H(2)O}(n) (), {[Cd(2)Sr(BTC)(2)(H(2)O)(5)]·H(2)O}(n) () and [Cd(6)Ba(3)(BTC)(3)(H(2)O)(10)](n) () (H(3)BTC = 1,3,5-benzenetricarboxylic acid), synthesized from H(3)BTC and the corresponding metal salts. Single-crystal X-ray analysis shows that compound is a three-dimensional (3D) framework based on heterometallic Cd-O-Cd-O-Mg inorganic chain subunits, ...
Seay Joseph F - - 2012
We examined the effect of body water deficits on standing balance and sought to determine if plasma hyperosmolality (Posm) and/or volume reduction (%ΔVplasma) exerted independent effects. Nine healthy volunteers completed three experimental trials which consisted of a euhydration (EUH) balance test, a water deficit session and a hypohydration (HYP) balance ...
Gerin Brigitte - - 2012
1. A fast, straightforward and cost-effective assay was validated for the assessment of CYP induction in cryopreserved human hepatocytes cultured in 48-well plates. The cocktail strategy (in situ incubation) was used to assess the induction of CYP1A2, CYP2B6, CYP2C9 and CYP3A4 by using the recommended probe substrate, i.e. phenacetin, bupropion, diclofenac ...
Campbell Sarah - - 2012
The purpose of this study was to determine the prevalence of children's food requests, and parents' experiences of food marketing directed towards children, in the supermarket environment. A mixed-method design was used. Firstly, intercept interviews were conducted with parents accompanied by a child/children on exiting supermarkets (sampled from a large ...
Chartrand Daniel - - 2012
The synthesis and characterization of a novel family of positively charged fac-[Re(bpy)(CO)(3)(L)]PF(6) (bpy = 2,2'-bipyridine) complexes are reported, where L is a pyridine functionalized in para or meta position with a fulvene moiety, namely, 4-fluoren-9-ylidenemethyl-pyridine (pFpy) and 3-fluoren-9-ylidenemethyl-pyridine (mFpy). The complexes were prepared in high yield (86%) by direct addition ...
Nguyen Linh - - 2012
ABSTRACT: BACKGROUND: Treatment of solid tumors with vascular disrupting agent OXi4503 results in over 90% tumor destruction. However, a thin rim of viable cells persists in the tumor periphery following treatment, contributing to subsequent recurrence. This study investigates inherent differences in the microenvironment of the tumor periphery that contribute to ...
Li123 Li-Fu - - 2012
ABSTRACT BACKGROUND: Mechanical ventilation used in patients with acute lung injury (ALI) can damage pulmonary epithelial cells through production of inflammatory cytokines and excess deposition of extracellular matrix protein lumican. Lumican participates in macrophage inflammatory protein (MIP)-2 and transforming growth factor (TGF)-β1 signaling during fibroproliferative phase of ALI, which involves ...
Meteyer Carol U - - 2012
White nose syndrome, caused by Geomyces destructans, has killed more than 5 million cave hibernating bats in eastern North America. During hibernation, the lack of inflammatory cell recruitment at the site of fungal infection and erosion is consistent with a temperature-induced inhibition of immune cell trafficking. This immune suppression allows ...
Paltrow Lynn M - - 2012
All pregnant women, not just those who seek to end a pregnancy, have benefited from Roe v Wade. Today's system of mass incarceration makes it likely that if Roe is overturned women who have abortions will go to jail. Efforts to establish separate legal "personhood" for fertilized eggs, embryos, and ...
Bhatt Deepak K - - 2012
BackgroundNXN-188 is a combined neuronal nitric oxide synthase (nNOS) inhibitor and 5-hydroxytryptamine 1B/1D (5-HT(1B/1D)) receptor agonist. Using preclinical models, we evaluated whether these two unique therapeutic principles have a synergistic effect in attenuating stimulated calcitonin gene-related peptide (CGRP) release, a marker of trigeminal activation.MethodsWe examined the effect of NXN-188 on: ...
Patel Pitambar - - 2012
A modular total synthesis of (-)-isatisine A is described in which four consecutive metal-mediated transformations have been employed at the final stage. These include [Pd]-catalyzed Sonogashira coupling, [Pd]-catalyzed nitroalkyne cycloisomerization leading to isatogens, addition of indoles to isatogens using InCl3 and [Rh]-catalyzed oxidative N-heterocyclization of amino alcohol to form the ...
Shakarchi Kamila - - 2012
The chemosensory roles of gill neuroepithelial cells (NECs) in mediating the hyperventilatory response to hypoxia are not clearly defined in fish. While serotonin (5-HT) is the predominant neurotransmitter in O2-sensitive gill NECs, acetylcholine (ACh) plays a more prominent role in O2 sensing in terrestrial vertebrates. The present study characterized the ...
Fujimoto Takeshi - - 2012
We systematically investigated the effects of loop length on the conformation, thermodynamic stability, and hydration of DNA G-quadruplexes under dilute and molecular crowding conditions in the presence of Na+. Structural analysis showed that molecular crowding induced conformational switches of oligonucleotides with the longer guanine stretch and the shorter thymine loop. ...
Hayashi Kyouhei - - 2012
Bifidobacterium asteroides, originally isolated from honeybee intestine, was found to grow under 20% O2 conditions in liquid shaking culture using MRS broth. Catalase activity was detected only in cells that were exposed to O2 and grown in the medium containing heme source, and these cells showed higher viability on exposure ...
Sandell Caroline - - 2012
Abstract Knowledge regarding neuropsychiatric disabilities has increased in recent years, resulting in an increasing number of adults requesting neuropsychiatric evaluation. The aim of this qualitative study was to describe adult clients' experiences of participating actively in a supportive assessment process in which they received a diagnosis of either autism spectrum ...
Ikeda Koki - - 2012
Previous studies utilizing the N2pc, an ERP correlate of attentional focusing, demonstrated that fearful faces grab attention regardless of their relevance to the current task. We tested whether this apparent automaticity was susceptible to high concurrent task demand, which is known to suppress other cortical and subcortical emotional evaluations. Our ...
Wang Kemin - - 2012
Living cell studies can offer tremendous opportunities for biological and disease studies. Due to their high sensitivity and selectivity, minimum interference with living biological systems, ease of design and synthesis, fluorescent nucleic acid probes (FNAPs) have been widely used in living cell studies, such as for intracellular detection, cell detection, ...
Saldana-Ruiz Nallely - - 2012
Objectives. We used the fundamental cause hypothesis as a framework for understanding the creation of health disparities in colorectal cancer mortality in the United States from 1968 to 2005. Methods. We used negative binomial regression to analyze trends in county-level gender-, race-, and age-adjusted colorectal cancer mortality rates among individuals ...
Hulskotte Ellen G J - - 2012
Background. Boceprevir represents a new treatment option for hepatitis C (HCV)-infected patients, including those with HCV/human immunodeficiency virus (HIV) coinfection; however, little is known about pharmacokinetic interactions between boceprevir and antiretroviral drugs.Methods. A randomized, open-label study to assess the pharmacokinetic interactions between boceprevir and ritonavir-boosted protease inhibitors (PI/r) was conducted in 39 ...
Marques Ana C - - 2012
ABSTRACT: BACKGROUND: Recent reports have highlighted instances of mRNAs that, in addition to coding for protein, regulate the abundance of related transcripts by altering miRNA availability. These two mRNA roles - one mediated by RNA and the other by protein - are inter-dependent and hence cannot easily be separated. Whether ...
Schoen Cathy - - 2012
Health reforms in high-income countries increasingly aim to redesign primary care to improve the health of the population and the quality of health care services, and to address rising costs. Primary care improvements aim to provide patients with better access to care and develop more-integrated care systems through better communication ...
Stickrath Andrew B - - 2012
While understanding the structural dynamics associated with ligand photodissociation is necessary in order to correlate structure and function in biological systems, few techniques are capable of measuring the ultrafast structural dynamics of these systems in solution-phase at room temperature. We present here a detailed X-ray transient absorption (XTA) study of ...
Hesling Cédric - - 2012
Transforming growth factor β (TGFβ) is widely recognised as an important factor that regulates many steps of normal mammary gland (MG) development, including branching morphogenesis, functional differentiation and involution. Tif1γ has previously been reported to temporally and spatially control TGFβ signalling during early vertebrate development by exerting negative effects over ...
Aydogan F - - 2012
Purpose:We aimed to evaluate the articular involvements in pediatric patients with familial Mediterranean fever (FMF) with joint symptoms by bone scintigraphy and to correlate the involved joints with the gene mutations.Materials and methods:A total of 41 newly diagnosed patients in pediatric age group (28 girls and 13 boys; mean age ...
Krieger Nancy - - 2012
How we think about biology-in historical, ecological, and societal context-matters for framing causes of and solutions to health inequities. Drawing on new insights from ecological evolutionary developmental biology and ecosocial theory, I question dominant gene-centric and ultimately static approaches to conceptualizing biology, using the example of the breast cancer estrogen ...
Deeds Daniel A - - 2012
Twenty-four halogenated volatile organic compounds (hVOCs) and SF6 were measured in groundwater samples collected from 312 wells across California at concentrations as low as 10(-12) grams per kilogram groundwater. The hVOCs detected are predominately anthropogenic (i.e. "ahVOCs") and as such their distribution delineates where groundwaters are impacted and susceptible to ...
Poineau Frederic - - 2012
Technetium is intimately linked with nuclear reactions. The ultraminute natural levels in the environment are due to the spontaneous fission of uranium isotopes. The discovery of technetium was born from accelerator reactions, and its use and presence in the modern world are directly due to nuclear reactors. While occupying a ...
Berger Slava - - 2012
RATIONALE: Mobilization and functions of endothelial progenitor cells (EPCs) are increased in acute myocardial infarction (AMI) patients. Yet, sleep disordered breathing (SDB) is highly prevalent in AMI patients. OBJECTIVE: To compare EPCs numbers and functions in AMI patients with SDB (AMI-SDB) and without SDB (AMI-only) and to determine the effects ...
Godlaski Theodore M - - 2012
The use of tobacco by Native Americans in North America seems to have ancient origins and significant spiritual meaning. This article reviews archeological and anthropological data about the use of tobacco and its sacred significance.
Chang Pi-Yueh - - 2012
Abstract Background: Oral cavity cancer ranks as the fourth leading cancer in men in Taiwan. The development of a serum biomarker panel for early detection and disease monitoring is, therefore, warranted. Methods: Nine inflammation-associated markers were investigated in 46 patients with leukoplakia, 151 patients with untreated oral cavity squamous cell ...
Meyer Sascha - - 2012
Most commonly pineal cysts are small, benign and asymptomatic lesions. Conversely, symptomatic pineal cysts are usually larger than those found incidentally. The incidence of symptomatic pineal cysts is highest in young women between 21 and 30 years of age, leading to the hypothesis that hormonal influences contribute to their etiology ...
An Qian - - 2012
Objectives. We examined the association between socioeconomic position (SEP) and HIV diagnosis rates in the United States and whether racial/ethnic disparities in diagnosis rates persist after control for SEP. Methods. We used cases of HIV infection among persons aged 13 years and older, diagnosed 2005 through 2009 in 37 states ...
Munene Esther - - 2012
In these colorful 2011 photographs, Burmese children are adorned with thanakha, a traditional decorative makeup. Thanakha (pronounced tha-na-KA) is obtained from grinding the bark of thanakha trees, which grow in Burma, Thailand, parts of India, and the Himalayas. Many different brands of this product are available commercially. The yellowish-white, creamy ...
Perret Jennifer L - - 2012
RATIONALE: The contribution by asthma to the development of fixed airflow obstruction and the nature of its effect combined with active smoking and atopy remain unclear. OBJECTIVES: To investigate the prevalence and relative influence of lifetime asthma, active smoking and atopy on fixed airflow obstruction in middle-age. METHODS: The population-based ...
Tuan Pham Anh - - 2012
Riboflavin (vitamin B2) is the universal precursor of the coenzymes flavin mononucleotide and flavin adenine dinucleotide-cofactors that are essential for the activity of a wide variety of metabolic enzymes in animals, plants, and microbes. Using the RACE PCR approach, cDNAs encoding lumazine synthase (McLS) and riboflavin synthase (McRS), which catalyze ...
Doran Neal - - 2012
This study tested whether DRD2/ANKK1 TaqIA genotype predicted smoking initiation and subsequent use, and effects were mediated by sensation seeking and negative urgency. Between 2009 and 2012, college never smokers (n = 387) completed six assessments over 15 months; those who reported smoking were classified as initiators. Logistic regression indicated ...
Manesh Kalayil Manian - - 2012
A new nanomotor-based surface-patterning technique based on the movement of a magnetically powered enzyme-functionalized flexible nanowire swimmer offers the ability to create complex helical metal microstructures.
Reisinger Kostan W - - 2012
BackgroundReintroduction of enteral nutrition in neonates with necrotizing enterocolitis (NEC) should take place when the gut is ready. Too early start of oral feeding might lead to disease relapse, whereas prolonged discontinuation of enteral nutrition is associated with impaired gut function and parenteral nutrition-related complications. This study evaluates whether non-invasive ...
Williams Callum - - 2012
Rapid adjustment to free-market systems, which often takes place during economic crises, poses serious problems for public health outcomes. At a time of economic crisis, it is particularly important to understand the relationship between economic circumstances and public health outcomes. As more countries are forced to adopt free-market models of ...
Ruwoldt Gina - - 2012
As Bauer et al. have quite rightly pointed out, children from families who experience food insecurity and who consume a diet that is often lacking in nutritional value are more likely to have poorer health outcomes.(1) (Am J Public Health. Published online ahead of print November 15, 2012: e1. doi:10.2105/AJPH.2012.301082).
Léger Juliane - - 2012
Graves' disease (GD) is the most common cause of hyperthyroidism in children. This review gives an overview and update of management of GD. Antithyroid drugs (ATD) are recommended as the initial treatment, but the major problem is the high relapse rate (30%) as remission is achieved after a first course ...
Barnett Carolina - - 2012
BACKGROUND: Intravenous immunoglobulin (IVIG) and plasmapheresis (plasma exchange (PLEX)) have comparable efficacy in reducing the Quantitative Myasthenia Gravis Score for disease severity (QMGS) in patients with moderate to severe myasthenia gravis (MG). OBJECTIVE: To determine if the improvement in the quality of life (QOL) after immunomodulation is comparable with either ...
Pronin Sergey V - - 2012
7-Isocyano-11(20),14-epiamphilectadiene, the most potent of antimalarial amphilectenes, is synthesized in seven steps from readily available materials. The synthesis is enabled by a new dendrimeric triene (Danishefsky [3]-dendralene) and a new method for stereo- and chemoselective isocyanation. This chemistry provides a useful entry into an underexplored yet promising family of antimalarial ...
Benoit Jean-Noël - - 2012
Bone is the most challenging tissue for DNA extraction and purification. Expensive commercial kits and specific equipments are often used in forensic and anthropology laboratories towards that goal. We present here an integrated procedure that gives satisfactory results for DNA preparation from fresh, ancient or weathered bones. Extraction is performed ...
Mie Yasuhiro - - 2012
DNA molecules have attracted considerable attention as functional materials in various fields such as electrochemical sensors with redox-labeled DNA. On the other hand, the recently developed interstrand cross-link (ICL) technique for double stranded DNA can adequately modify the electronic property inside the duplex. Hence, the electrochemical investigation of ICL-DNA helps ...
Salamone Michela - - 2012
Abstract. A kinetic study on hydrogen abstraction from strong hydrogen bond acceptors such as DMSO, HMPA and tributylphosphine oxide (TBPO) by the cumyloxyl (CumO•) and benzyloxyl (BnO•) radicals was carried out in acetonitrile. The reactions with CumO• were described in terms of a direct hydrogen abstraction mechanism, in line with ...
Vayena E - - 2012
Aims: This study explores attitudes, motivations and self-reported impact in connection with direct-to-consumer (DTC) genomic testing amongst a group of life scientists in Switzerland. Methods: Data were collected through: (1) a self-completion online questionnaire, and (2) semi-structured qualitative interviews. Forty participants completed the questionnaire and 10 were interviewed. Results: Curiosity ...
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