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Results 501 - 550 of 2118
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Krantz Mori J - - 2012
Objectives. We evaluated whether a program to prevent coronary heart disease (CHD) with community health workers (CHWs) would improve CHD risk in public health and health care settings. Methods. The CHWs provided point-of-service screening, education, and care coordination to residents in 34 primarily rural Colorado counties. The CHWs utilized motivational ...
Chen Yongfei - - 2012
To investigate the antihypertensive effects and tolerability of aliskiren in comparison with other antihypertensive drugs and placebo in patients with hypertension, a meta-analysis was performed of studies published between 1950 and 2012. A systematic literature search of MEDLINE and the Cochrane Library was conducted for randomized controlled trials. Weighted mean ...
Santoro Marta - - 2012
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear hormone receptor expressed predominantly in adipose tissue, and it is implicated in energy homeostasis. In this study, by Western blotting and Immunofluorescence techniques, we demonstrated for the first time that pig spermatozoa express the PPARγ. To investigate the functional role of PPARγ ...
Sur Shantanu S Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, Illinois 60611, - - 2012
Self-assembling peptide materials have been used extensively to mimic natural extracellular matrices (ECMs) by presenting bioactive epitopes on a synthetic matrix. Although this approach can facilitate a desired response from cells grown in the matrix, it lacks the capacity for spatial or temporal regulation of the presented signals. We describe ...
Mazor Rafi R Department of Bioengineering, The Institute of Engineering in Medicine, Veterans Affairs Medical Center, San Diego, California, USA. - - 2013
Matrix metalloproteinase-1 (MMP-1) is a collagenase that is highly active in extracellular matrix and vascular remodeling, angiogenesis, and tumor progression. Vascular endothelial growth factor receptor-2 (VEGFR2), the main receptor for VEGF-A, is expressed on endothelial cells and promotes cell survival, proliferation, and other functions. Although MMP-1 and VEGFR2 co-exist in ...
McQuiston Jennifer H - - 2012
Abstract Several spotted fever group rickettsiae (SFGR) previously believed to be nonpathogenic are speculated to contribute to infections commonly misdiagnosed as Rocky Mountain spotted fever (RMSF) in the United States, but confirmation is difficult in cases with mild or absent systemic symptoms. We report an afebrile rash illness occurring in ...
Sendker Jandirk - - 2012
The rational use of hawthorn leafs and flowers from Crataegus spp. for declining cardiac performance is mainly due to flavon-C-glycosides and oligomeric procyanidins (OPC). From OPC-enriched extracts from different batches, a dimeric phenylpropanoid-substituted procyanidin (cinchonain II b, 1) was isolated and characterized by MS, CD, and NMR. Also the presence of ...
Liu Xiuxia - - 2012
PtdIns synthase is a key enzyme in the phospholipid pathway and catalyses the formation of PtdIns. PtdIns is not only a structural component of cell membranes, but also the precursor of the phospholipid signal molecules which regulate plant response to environment stresses. Here, we obtained transgenic maize constitutively overexpressing or ...
Wang Kemin - - 2012
Living cell studies can offer tremendous opportunities for biological and disease studies. Due to their high sensitivity and selectivity, minimum interference with living biological systems, ease of design and synthesis, fluorescent nucleic acid probes (FNAPs) have been widely used in living cell studies, such as for intracellular detection, cell detection, ...
Saldana-Ruiz Nallely - - 2012
Objectives. We used the fundamental cause hypothesis as a framework for understanding the creation of health disparities in colorectal cancer mortality in the United States from 1968 to 2005. Methods. We used negative binomial regression to analyze trends in county-level gender-, race-, and age-adjusted colorectal cancer mortality rates among individuals ...
Kudo Wataru W Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, - - 2013
Soluble oligomeric amyloid-β (Aβ) has been suggested to impair synaptic and neuronal function, leading to neurodegeneration that is clinically observed as the memory and cognitive dysfunction characteristic of Alzheimer disease, while the precise mechanism(s) whereby oligomeric Aβ causes neurotoxicity remains unknown. Recently, the cellular prion protein (PrP (C) ) was ...
Hulskotte Ellen G J - - 2012
Background. Boceprevir represents a new treatment option for hepatitis C (HCV)-infected patients, including those with HCV/human immunodeficiency virus (HIV) coinfection; however, little is known about pharmacokinetic interactions between boceprevir and antiretroviral drugs.Methods. A randomized, open-label study to assess the pharmacokinetic interactions between boceprevir and ritonavir-boosted protease inhibitors (PI/r) was conducted in 39 ...
Marques Ana C - - 2012
ABSTRACT: BACKGROUND: Recent reports have highlighted instances of mRNAs that, in addition to coding for protein, regulate the abundance of related transcripts by altering miRNA availability. These two mRNA roles - one mediated by RNA and the other by protein - are inter-dependent and hence cannot easily be separated. Whether ...
Schoen Cathy - - 2012
Health reforms in high-income countries increasingly aim to redesign primary care to improve the health of the population and the quality of health care services, and to address rising costs. Primary care improvements aim to provide patients with better access to care and develop more-integrated care systems through better communication ...
Stickrath Andrew B - - 2012
While understanding the structural dynamics associated with ligand photodissociation is necessary in order to correlate structure and function in biological systems, few techniques are capable of measuring the ultrafast structural dynamics of these systems in solution-phase at room temperature. We present here a detailed X-ray transient absorption (XTA) study of ...
Hesling Cédric - - 2012
Transforming growth factor β (TGFβ) is widely recognised as an important factor that regulates many steps of normal mammary gland (MG) development, including branching morphogenesis, functional differentiation and involution. Tif1γ has previously been reported to temporally and spatially control TGFβ signalling during early vertebrate development by exerting negative effects over ...
Rechner Laura A LA Department of Radiation Physics, Graduate School of Biomedical Sciences, The University of Texas Health Science Center Houston, Houston, TX 77030, - - 2012
We previously determined that the predicted risk of radiogenic second cancer in the bladder and rectum after proton arc therapy (PAT) was less than or equal to that after volumetric modulated arc therapy (VMAT) with photons, but we did not consider the impact of margin size on that risk. The ...
Lu Jinzhen - - 2012
Careful control of the reaction stoichiometry and conditions enables the synthesis of both LiTCNQF(4) and Li(2)TCNQF(4) to be achieved. Reaction of LiI with TCNQF(4), in a 4:1 molar ratio, in boiling acetonitrile yields Li(2)TCNQF(4). However, deviation from this ratio or the reaction temperature gives either LiTCNQF(4) or a mixture of ...
Hennessy Michael - - 2013
We estimated the long-term (36-month) effects of Project iMPPACS, a multisite randomized controlled trial of mass media and small-group intervention for African American adolescents. We collected 6 waves of longitudinal data on program participants aged 14 to 17 years (n = 1139) in Providence, Rhode Island; Syracuse, New York; Columbia, ...
Nelson Christian J - - 2012
Introduction.  Peyronie's disease (PD) is characterized by an accumulation of scar tissue in the tunica albuginea of the penis that causes curvature and deformity. PD can result in psychological distress, depression, or anxiety, which often goes untreated. Aims.  To review the current literature on the psychological impact of PD, educate ...
Sundström Karin K Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, P.O. Box 281, S-171 77 Stockholm, Sweden. - - 2013
A strong association has been shown between high viral DNA load (VL) of human papillomavirus (HPV) type 16 and risk for cervical cancer in situ (CIS). However, little data is available for the significance of VL in invasive squamous cell carcinoma (SCC). In 2 nested case-control studies among women participating ...
Alemán José - - 2012
In the last decade, organocatalysis, the use of small chiral organic molecules as catalysts, has proven to be a valuable and attractive tool for the synthesis of enantiomerically enriched molecules. A number of organocatalysts and processes, such as one-pot, tandem, cascade or multicomponent reactions, have been reported to date. Furthermore, ...
Chalot Michel - - 2012
We investigated the fate of trace elements (TE) in poplar wood on the conversion of biomass to heat in a 0.2 MW combustion unit equipped with a fabric filter. The phytoremediation wood was harvested from a TE-contaminated agricultural site planted with a high-density poplar stand. The combustion technology used in ...
Dougherty Max - - 2012
Development of the palate in vertebrates involves cranial neural crest migration, convergence of facial prominences and extension of the cartilaginous framework. Dysregulation of palatogenesis results in orofacial clefts, which represent the most common structural birth defects. Detailed analysis of zebrafish palatogenesis revealed distinct mechanisms of palatal morphogenesis: extension, proliferation and ...
Yue C S - - 2012
To better understand the pharmacokinetics and potential advantages of a levothyroxine oral solution vs. tablets and soft gel capsules.4 randomized, 2-treatment, single-dose (600 mcg levothyroxine), 2-way crossover bioequivalence studies in 84 healthy subjects were analyzed. Samples were collected before dosing and until 48-72 h post-dose to calculate noncompartmental baseline-adjusted pharmacokinetic parameters: ...
Bolaño Tamara - - 2012
The facile and high-yield reaction between aniline and cis-positioned nitriles of [((t)bpy)(2)Rh(NCR)(2)][OTf](3) [R = Me (), Ph (); (t)bpy = 4,4'-di-tert-butyl-2,2'-bipyridine; OTf = CF(3)SO(3)(-)] produces the Rh(III)-triazapentadiene species [((t)bpy)(2)[upper bond 1 start]Rh{NH[double bond, length as m-dash]C(R)N(Ph)C(R)[double bond, length as m-dash]N[upper bond 1 end]H}][OTf](3) [R = Me (), Ph ()]. It ...
Chew Ng Rilene A - - 2012
Objectives. We examined primary and secondary syphilis cases among men who have sex with men (MSM) in California, and the association of methamphetamine use and Internet use to meet sex partners (Internet use) with number of sex partners. Methods. We analyzed California surveillance data for MSM who were diagnosed with ...
Liu Yan - - 2012
Previous studies have shown that by minimizing the total variation (TV) of the to-be-estimated image with some data and other constraints, piecewise-smooth x-ray computed tomography (CT) can be reconstructed from sparse-view projection data without introducing notable artifacts. However, due to the piecewise constant assumption for the image, a conventional TV ...
Said Somiraa S - - 2012
Therapeutic angiogenesis is a new revascularization strategy involving the administration of growth factors to induce new vessel formation. The biology and delivery of angiogenic growth factors involved in vessel formation have been extensively studied but success in translating the angiogenic capacity of growth factors into benefits for vascular disease patients ...
Wang Bijun - - 2012
Perovskite-type oxide LaNiO(3) nanofibers (LNFs) have been successfully synthesized by electrospinning and sequential calcinations. The electrospun LNFs modified carbon paste electrode was used to construct a nonenzymatic hydrogen peroxide (H(2)O(2)) sensor and glucose biosensor for the first time. The LNFs composition was verified by X-ray diffraction, and the morphologies were ...
Waiswa Peter - - 2012
ABSTRACT: BACKGROUND: Reducing neonatal-related deaths is one of the major bottlenecks to achieving Millennium Development Goal 4. Studies in Asia and South America have shown that neonatal mortality can be reduced through community-based interventions, but these have not been adapted to scalable intervention packages for sub-Saharan Africa where the culture, ...
Seidman Gwendolyn - - 2012
Abstract The current study examined viewers' gaze while observing Facebook profiles of strangers varying in gender and physical attractiveness. Fifty-one participants viewed four Facebook profiles, a physically attractive and unattractive individual of each gender. Participants' eye movements were tracked as they viewed each profile for 60 seconds. Results showed that ...
Ambade Vipul Namdeorao - - 2012
The cause and manner of death in submersion cases are a routine challenge for forensic pathologists as they present considerable diagnostic difficulties. The present study was undertaken with a view to determine the characteristic pattern in bodies retrieved from water. From a total of 6779 medicolegal deaths reported at an ...
Uchea Chibuzor - - 2012
1. In vitro screens are sought as informative, alternatives to the use of animals in vivo and to improve upon the current use of fish liver 9000 g supernatants (S9) in environmental risk assessment. 2. The rates of ethoxyresorufin-O-deethylation (relative to S9 protein) measured under different conditions of culture of rainbow trout hepatocytes ...
Kim Kitae - - 2012
Manganese is one of the common elements in the earth crust and an essential micronutrient for all living things. The reductive dissolution of particulate manganese oxide is a dominant process to enhance mobility and bioavailability of manganese for the use of living organisms. In this work, we investigated the reductive ...
Barceló Antonia - - 2012
Background: Vitamin D insufficiency and high levels of parathyroid hormone (PTH) appear to be emerging risk factors for metabolic syndrome (MS), diabetes and cardiovascular disease, conditions that occur frequently in patients with obstructive sleep apnea syndrome (OSAS). Objectives: This study examined whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] and PTH ...
Yang Heejung - - 2012
Bioassay-guided fractionation of an 80 % methanolic extract of Salix pseudo-lasiogyne twigs has resulted in the isolation of two new compounds (1-2) along with ten known ones (3-12). The new compounds were determined to be 3'-O-acetylsalicin (1) and 2',6'-O-acetylsalicortin (2) by using spectroscopic analyses. Compounds (3-12) were identified as salicin (3), ...
Yang Yanmei - - 2012
The most notable role of small interfering RNA (siRNA) is in RNA interference (RNAi) and post-transcriptional gene silencing, which leads to a surge of interest in RNAi for both biomedical research and therapeutic applications. However, "naked" siRNA cannot cross cellular membranes freely because of highly negative charges which limits its ...
Paltrow Lynn M - - 2012
All pregnant women, not just those who seek to end a pregnancy, have benefited from Roe v Wade. Today's system of mass incarceration makes it likely that if Roe is overturned women who have abortions will go to jail. Efforts to establish separate legal "personhood" for fertilized eggs, embryos, and ...
Bhatt Deepak K - - 2012
BackgroundNXN-188 is a combined neuronal nitric oxide synthase (nNOS) inhibitor and 5-hydroxytryptamine 1B/1D (5-HT(1B/1D)) receptor agonist. Using preclinical models, we evaluated whether these two unique therapeutic principles have a synergistic effect in attenuating stimulated calcitonin gene-related peptide (CGRP) release, a marker of trigeminal activation.MethodsWe examined the effect of NXN-188 on: ...
Patel Pitambar - - 2012
A modular total synthesis of (-)-isatisine A is described in which four consecutive metal-mediated transformations have been employed at the final stage. These include [Pd]-catalyzed Sonogashira coupling, [Pd]-catalyzed nitroalkyne cycloisomerization leading to isatogens, addition of indoles to isatogens using InCl3 and [Rh]-catalyzed oxidative N-heterocyclization of amino alcohol to form the ...
Girardot Michael - - 2012
More than a hundred protein-coding genes are controlled by genomic imprinting in humans. These atypical genes are organized in chromosomal domains, each of which is controlled by a differentially methylated "imprinting control region" (ICR). How ICRs mediate the parental allele-specific expression of close-by genes is now becoming understood. At several ...
Shakarchi Kamila - - 2012
The chemosensory roles of gill neuroepithelial cells (NECs) in mediating the hyperventilatory response to hypoxia are not clearly defined in fish. While serotonin (5-HT) is the predominant neurotransmitter in O2-sensitive gill NECs, acetylcholine (ACh) plays a more prominent role in O2 sensing in terrestrial vertebrates. The present study characterized the ...
Fujimoto Takeshi - - 2012
We systematically investigated the effects of loop length on the conformation, thermodynamic stability, and hydration of DNA G-quadruplexes under dilute and molecular crowding conditions in the presence of Na+. Structural analysis showed that molecular crowding induced conformational switches of oligonucleotides with the longer guanine stretch and the shorter thymine loop. ...
Fjellström Ola O Department of Medicinal Chemistry, AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden. - - 2013
A novel class of small molecule inhibitors for plasminogen activator inhibitor type 1 (PAI-1), represented by AZ3976, was identified in a high throughput screening campaign. AZ3976 displayed an IC(50) value of 26 μm in an enzymatic chromogenic assay. In a plasma clot lysis assay, the compound was active with an ...
Hayashi Kyouhei - - 2012
Bifidobacterium asteroides, originally isolated from honeybee intestine, was found to grow under 20% O2 conditions in liquid shaking culture using MRS broth. Catalase activity was detected only in cells that were exposed to O2 and grown in the medium containing heme source, and these cells showed higher viability on exposure ...
Sandell Caroline - - 2012
Abstract Knowledge regarding neuropsychiatric disabilities has increased in recent years, resulting in an increasing number of adults requesting neuropsychiatric evaluation. The aim of this qualitative study was to describe adult clients' experiences of participating actively in a supportive assessment process in which they received a diagnosis of either autism spectrum ...
Ikeda Koki - - 2012
Previous studies utilizing the N2pc, an ERP correlate of attentional focusing, demonstrated that fearful faces grab attention regardless of their relevance to the current task. We tested whether this apparent automaticity was susceptible to high concurrent task demand, which is known to suppress other cortical and subcortical emotional evaluations. Our ...
Haque Aftabul - - 2012
We describe a phage display approach that we have previously used to generate conformation-sensor antibodies that specifically recognize and stabilize the oxidized, inactive conformation of protein tyrosine phosphatase 1B (PTP1B). We use a solution-based panning and screening strategy conducted in the presence of reduced active PTP1B, which enriches antibodies to ...
Tanabe J - - 2012
BACKGROUND AND PURPOSE:Frontolimbic circuits are involved in learning and decision-making processes thought to be affected in substance-dependent individuals. We investigated frontolimbic cortical morphometry in substance-dependent men and women and determined whether morphometric measurements correlated with decision-making performance.MATERIALS AND METHODS:Twenty-eight abstinent SDI (17 men/11 women) were compared with 28 controls (13 ...
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