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Treadwell Henrie M - - 2012
The October 2011 release of the European Commission (EC) report on the state of men's health in the European Union (EU)(1,2) focused attention on men's health around the world. It also inspired calls for a report on the state of men's health in the United States, among other regions. These ...
Papakostas J C - - 2012
OBJECTIVES: To examine and compare the effects of downwards versus upwards total stripping of great saphenous vein (GSV) on saphenous nerve (SN) injury using clinical and electrophysiological studies. METHODS: Fifty patients with varicosities were equally and randomly assigned to undergo total, upwards stripping (group A) or downwards stripping (group B) ...
Rydevik Axel - - 2012
1. Selective androgen receptor modulators (SARMs) are a group of substances that have potential to be used as doping agents in sports. Being a relatively new group not available on the open market means that no reference materials are commercially available for the main metabolites. In the presented study, the in ...
Fungfuang Wirasak - - 2012
The puberty onset in mammals is tightly coupled to the animal's nutritional and metabolic state. In present study, we evaluated the effects of high fat diet on leptin, adiponectin levels, leptin mRNA expression and puberty onset in female rats. On day 21, female rats were divided into 2 groups; Normal ...
Hyun Youbong - - 2012
Mitotic inheritance of identical cellular memory is crucial for development in multicellular organisms. The cell type-specific epigenetic state should be correctly duplicated upon DNA replication to maintain cellular memory during tissue and organ development. Although a role of DNA replication machinery in maintenance of epigenetic memory has been proposed, technical ...
Zhang Wenjing - - 2012
Density functional theory (DFT) calculations have been performed to provide the first detailed computational study on the mechanism and enantioselectivity for the [4+2] cycloaddition reaction of ketenes with N-benzoyldiazenes catalyzed by N-heterocyclic carbenes (NHCs). Two possible mechanisms have been studied: first is the "ketene-first" mechanism (Mechanism A) and second is ...
Brown Geoffrey - - 2012
Since the early 1980s, developing haematopoietic cells have been categorised into three well-defined compartments: multi-potent haematopoietic stem cells (HSC), which are able to self-renew, followed by haematopoietic progenitor cells (HPC), which undergo decision-making and age as they divide rather than self-renew, and the final compartment of functional blood and immune ...
Du Zhenting - - 2012
The combination of transition metal catalysis and organocatalysis as a new and exciting research area has attracted increasing attention as it can enable the development of unprecedented transformations that is not possible by use of either of the catalytic systems alone, and can improve the reactivity, efficiency and stereocontrol of ...
Maekawa Shun - - 2012
Hematopoietic responses to environmental factors are not fully characterized. Polycythemia has been reported during exposure to low temperatures in ectothermic animals. The relationship between the causes of polycythemia and erythropoiesis during low-temperature exposure is not fully understood. In this study, we exposed C57BL/6 mice to 5°C and monitored the blood ...
Atmaca Akin - - 2012
ABSTRACT: BACKGROUND: The epidermal growth factor receptor (EGFR) is a potential target of anticancer therapy in gastric cancer. However, its prognostic role in metastatic gastric or gastroesophageal junction (GE) cancer has not been established yet. METHODS: EGFR status was analyzed by immunohistochemistry (IHC) in paraffin-embedded samples from 357 patients who ...
Gebb Sarah A - - 2012
Background: Numerous studies in cultured cells indicate that damage to mitochondrial DNA (mtDNA) dictates cellular responses to oxidant stress, yet the consequences of mtDNA damage have not been studied directly in the preterm lung. Objective: We sought to determine whether hyperoxia-induced fetal lung dysmorphogenesis is linked to mtDNA damage and ...
Brenton J Nicholas - - 2012
The authors report the case of a 4-year-old boy who developed progressive unilateral weakness and developmental delays prior to his diagnosis of classical homocystinuria. Magnetic resonance imaging (MRI) of the brain demonstrated diffuse white matter changes, raising the concern for a secondary diagnosis causing leukoencephalopathy, since classical homocystinuria is not ...
Joffe Carole - - 2012
The field of abortion counseling originated in the abortion rights movement of the 1970s. During its evolution to the present day, it has faced significant challenges, primarily arising from the increasing politicization and stigmatization of abortion since legalization. Abortion counseling has been affected not only by the imposition of anti-abortion ...
Linos Natalia - - 2012
Objectives. We examined whether social norms toward spousal violence in Nigeria, at the state level, are associated with a woman's exposure to physical and sexual violence perpetrated by her husband. Methods. Using data from the 2008 Demographic and Health Survey, we fit four 3-level random intercepts models to examine contextual ...
Steiner Genevieve Z - - 2012
This study examined temporal determinants of the P300 component of the ERP in a three-stimulus visual oddball task. Frequent standards, with equiprobable targets and infrequent nontargets, were utilized. We tested whether the infrequent nontarget-to-nontarget interval (infrequent NNI) influences P300 amplitudes and latencies analogously to the target-to-target interval (TTI). EEG was ...
Germay Olivier - - 2012
The tin(iv) chloride mediated cyclisation of (Z)-homoallylic alcohols using phenylselenenyl chloride or phthalimide in the presence of a Lewis acid followed by reductive removal of the phenylselenenyl group was found to give 2,5-cis-disubstituted tetrahydrofurans with excellent stereocontrol. Using this procedure, (2S,4S,8R,6Z)-9-benzyloxy-2-tert-butyldiphenylsilyloxy-8-methylnon-6-en-4-ol (), prepared stereoselectively via the tin(iv) chloride promoted reaction ...
Scantlebury C E - - 2012
Ocular disease is a frequent finding in working horses. This study aimed to estimate the prevalence and types of ocular pathology, and explore risk factors potentially associated with disease within a population of working horses in Ethiopia. In total, 1049 horses were selected from horses attending clinics run by the ...
Rowe Annette Ruth - - 2012
Molecular biomarkers hold promise for inferring rates of key metabolic activities in complex microbial systems. However, few studies have assessed biomarker levels for simultaneously occurring (and potentially competing) respirations. In this study methanogenesis biomarkers for Methanospirillum hungatei were developed, tested and compared to Dehalococcoides mccartyi biomarkers in a well-characterized mixed ...
Jeong Byeong-Ho - - 2012
Background. There are limited data on the performance of the pneumonia severity index (PSI) and CURB-65, which were originally developed for community-acquired pneumonia (CAP), for patients with healthcare-associated pneumonia (HCAP).Methods. The performances of PSI and CURB-65 were retrospectively evaluated in patients with HCAP compared to patients with CAP using prospectively collected data ...
Nelson Samantha A - - 2012
OBJECTIVE: To compare the long-term outcome of tibial plateau leveling osteotomy (TPLO) and extracapsular repair (ECR) for treatment of a ruptured cranial cruciate ligament (RCCL). STUDY DESIGN: Prospective clinical trial. ANIMALS: Normal adult dogs (control, n = 79); dogs with unilateral CCL disease (n = 38). METHODS: Dogs had TPLO ...
Sengupta Arkajyoti - - 2012
Mechanism and the origin of enantioselectivity in the decarboxylative protonation of alpha-amino malonate hemiester promoted by epicinchona-thiourea hybrid organocatalyst is established by using the DFT(M06-2X/6-311+G**//ONIOM2) computational methods. The origin of stereoselectivity rendered by this hybrid bifunctional catalyst in asymmetric protonation is investigated for the first time using suitable transition state ...
Stürmer Birgit - - 2012
When the lateralized readiness potential (LRP) is recorded in stimulus-response compatibility (SRC) tasks, two processes may overlap in the LRP, stimulus-driven response priming and activation based on response selection rules. These overlapping processes are hard to disentangle with standard analytical tools. Here, we show that Residue Iteration Decomposition (RIDE), based ...
Alford Joshua S - - 2012
Warming of 4-phthalimido-N-mesyl-1,2,3-triazole in the presence of alkenes followed by silica gel induced hydrolysis results in a highly diastereoselective and catalyst-free entry to N-phthalimidocyclopropanecarboxaldehydes.
Tchankouo-Nguetcheu Stephane - - 2012
ABSTRACT: BACKGROUND: Arthropod-borne viral infections cause several emerging and resurging infectious diseases. Among the diseases caused by arboviruses, chikungunya is responsible for a high level of severe human disease worldwide. The salivary glands of mosquitoes are the last barrier before pathogen transmission. We undertook a proteomic approach to characterize the ...
Abolaji A O - - 2012
Among the artemisinin-based combination therapy (ACT) regimens, artemisinin derivative, artemether in combination with lumefantrine (artemether-lumefantrine, AL) has achieved excellent results in the fight against malarial scourge. In this study, we evaluated the toxic potential of these drugs at the therapeutic doses in female Wistar rats. Animals were randomly divided into ...
Muhammad Riyadh D - - 2012
Background. Certain chronic diseases increase risk for invasive pneumococcal disease (IPD) and are indications for receipt of 23-valent pneumococcal polysaccharide vaccine (PPV23). Since the pediatric introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in 2000, incidence of IPD among adults has declined. The relative magnitude of these indirect effects among persons with ...
Wang Tuo - - 2012
Macrocycles made of cholate building blocks were previously found to transport glucose readily across lipid bilayers. In this study, an 15N, 13Cα-labeled glycine was inserted into a cyclic cholate trimer and attached at the end of a linear trimer, respectively. The isotopic labeling allowed us to use solid-state NMR spectroscopy ...
Kawabe Keiko - - 2012
We have generated a monoclonal antibody (R-10G) specific to human induced pluripotent stem (hiPS)/embryonic stem (hES) cells by using hiPS cells (Tic) as an antigen, followed by differential screening of mouse hybridomas with hiPS and human embryonal carcinoma (hEC) cells. Upon Western blotting with R-10G, human iPS/ES cell lysates gave ...
Ma Kaige - - 2012
Self-assembling peptide nanofiber scaffolds have been studied extensively as biological materials for 3-dimensional cell culture and repairing tissue defects in animals. However, few studies have applied peptide nanofiber scaffolds in the tissue engineering of intervertebral discs (IVDs). In this study, a novel functionalized peptide scaffold was specifically designed for IVD ...
Ford James D - - 2012
I fully agree with the points made by Macpherson and Akpinar-Elci, who note the significant vulnerabilities faced by small island nations to the health effects of climate change. Small island nations, like the indigenous populations profiled in my article, are considered to be highly vulnerable to the health effects of ...
Pérez Mayrim L - - 2012
OBJECTIVE: To describe the clinical signs, treatment, and outcomes of dogs and cats following envenomation by the eastern coral snake and to report our clinical experience with the use of Coralmyn. DESIGN: Retrospective study (1996-2011). SETTING: University teaching hospital. ANIMALS: Sixteen dogs and 4 cats with eastern coral snake envenomation. ...
Dagorn Audrey - - 2012
Gamma aminobutyric acid (GABA) is widespread in the environment and can be used by animal and plants as a communication molecule. Pseudomonas and particularly fluorescent Pseudomonas synthesize GABA and express GABA-binding proteins. In this study, we investigated the effects of GABA on the virulence of Pseudomonas aeruginosa. While exposure to ...
Jilani S Mahaboob - - 2012
Graphene oxide (GO) and graphene oxide-zinc oxide nanocomposites (GO-ZnO) were used as channel materials on SiO(2)/Si to fabricate thin-film transistors (TFT) with an aluminum source and drain. Pure GO-based TFT showed poor field-effect characteristics. However, GO-ZnO-nanocomposite-based TFT showed better field-effect performance because of the anchoring of ZnO nanostructures in the ...
Fried Marlene Gerber - - 2012
Since the US Supreme Court decision legalizing abortion (Roe v. Wade), there has been a constant and broad attack on all aspects of women's reproductive and parenting rights. The consequences have been devastating, especially for women whose race, age, legal, or economic status makes them targets of discrimination. At the ...
Gasse Christiane - - 2012
Objective: We investigated the association between unipolar depression and incident hospital admissions due to ischemic heart disease, invasive cardiac procedures and mortality independent of other medical illnesses.Methods: A population-based cohort of 4.6 million persons aged 15 years or older and born in Denmark was followed up from 1995-2009. Incidence rate ...
Deng Changchun - - 2012
Brentuximab vedotin (SGN-35), an intravenously administered CD30-specific antibody-drug conjugate, has recently been approved by the U.S. Food and Drug Administration for two indications, including (1) patients with Hodgkin's lymphoma (HL) relapsing after autologous stem cell transplantation (ASCT), or after two multi-drug regimens in HL patients who are not candidates for ...
Alajarín Mateo - - 2012
A number of N-aryl ketenimines, substituted at the ortho position either with different non-cyclic acetalic functions (acetals, monothioacetals, dithioacetals) or with only one alkoxymethyl or (alkylthio)methyl group, have been prepared and submitted to thermal treatment in toluene solution. Under smooth heating the ketenimines bearing non-cyclic acetals converted into 3,4-dihydroquinolines following ...
McLean Natalie - - 2012
Purpose:The aim of this study was to document the range and frequency of ethical dilemmas associated with genetic testing encountered by genetic health professionals and to determine the strategies used to manage them.Methods:An online survey was used to document how often the 11 key ethical dilemmas have been encountered; whether ...
Pham Tài - - 2012
RATIONALE: Many patients with severe acute respiratory distress syndrome (ARDS) caused by influenza A(H1N1) infection received Extracorporeal Membrane Oxygenation (ECMO) as a rescue therapy. OBJECTIVES: To analyze factors associated with death in ECMO-treated patients and the influence of ECMO on ICU mortality. METHODS: Data from patients admitted for (H1N1)-associated ARDS ...
Grandvuillemin Aurélie - - 2012
OBJECTIVES: To compare characteristics of patients exhibiting cetuximab infusion reactions or another adverse drug reaction related to cetuximab and to identify factors associated with the severity of cetuximab infusion reactions. METHODS: All cases of adverse drug reaction reported with cetuximab from 1985 to 2010 were extracted from the French Pharmacovigilance ...
Bennett Simon J - - 2012
The current study examined the effect of inter-ocular delay in a manual aiming task that required accurate end-point placement, but not precise control of a grip aperture. Participants aimed in binocular, monocular, or alternating monocular vision conditions. For the latter, 25ms monocular samples were provided to alternate eyes without delay ...
Ogawa Kotaro - - 2012
1. Focusing on the genetic similarity of CYP3A subfamily enzymes (CYP3A4 and CYP3A5) between monkeys and humans, we have attempted to provide a single-species approach to predicting human hepatic clearance (CL(h)) of CYP3A4 substrates using pharmacokinetic parameters in cynomolgus monkeys following intravenous administrations. 2. Hepatic intrinsic clearance (CL(int,h)) of six ...
Mu Xiaoqin - - 2012
Abstract Oxidative stress has been linked to endothelial dysfunction in atherosclerosis and hypertension. The present study was designed to investigate the effect of hydrogen peroxide (H(2)O(2)) on angiotensin-converting enzyme (ACE), a key regulator of the renin-angiotensin system, and the mechanisms underlying ACE regulation in human umbilical vein endothelial cells (HUVECs). ...
Acampora Dario - - 2012
Mouse embryonic stem cells (ESCs) represent the naïve ground state of the preimplantation epiblast and epiblast stem cells (EpiSCs) represent the primed state of the postimplantation epiblast. Studies have revealed that the ESC state is maintained by a dynamic mechanism characterized by cell-to-cell spontaneous and reversible differences in sensitivity to ...
Leguay Sébastien - - 2012
Complexation of trivalent actinides with DTPA (diethylenetriamine pentaacetic acid) was studied as a function of pcH and temperature in (Na,H)Cl medium of 0.1 M ionic strength. Formation constants of both complexes AnHDTPA(-) and AnDTPA(2-) (where An stands for Am, Cm, and Cf) were determined by TRLFS, CE-ICP-MS, spectrophotometry, and solvent ...
Kupce Eriks - - 2012
We propose a new general form of two-dimensional spectroscopy where the indirect 'evolution' dimension is derived using the Radon transform. This idea is applicable to several types of spectroscopy but is illustrated here for the case of NMR. This 'projection spectroscopy' displays characteristic correlation peaks that highlight perturbations of chemical ...
Dodge Natasha - - 2012
In their recent article Gowda et al. describe a potential pathway by which food insecurity is associated with adverse health outcomes in the US population.(1) By measuring levels of C-reactive protein-a biomarker of inflammation linked to health conditions such as diabetes and cardiovascular disease-the study demonstrates a potential mechanism for ...
Zhang Xin - - 2012
Alkaline-earth metal ions were used to tune four new heterometallic frameworks, {[Cd(2.07)Mg(0.93)(BTC)(2)(H(2)O)(4)]·2H(2)O}(n) (), {[Cd(2)Ca(BTC)(2)(H(2)O)(4)]·2H(2)O}(n) (), {[Cd(2)Sr(BTC)(2)(H(2)O)(5)]·H(2)O}(n) () and [Cd(6)Ba(3)(BTC)(3)(H(2)O)(10)](n) () (H(3)BTC = 1,3,5-benzenetricarboxylic acid), synthesized from H(3)BTC and the corresponding metal salts. Single-crystal X-ray analysis shows that compound is a three-dimensional (3D) framework based on heterometallic Cd-O-Cd-O-Mg inorganic chain subunits, ...
Seay Joseph F - - 2012
We examined the effect of body water deficits on standing balance and sought to determine if plasma hyperosmolality (Posm) and/or volume reduction (%ΔVplasma) exerted independent effects. Nine healthy volunteers completed three experimental trials which consisted of a euhydration (EUH) balance test, a water deficit session and a hypohydration (HYP) balance ...
Gerin Brigitte - - 2012
1. A fast, straightforward and cost-effective assay was validated for the assessment of CYP induction in cryopreserved human hepatocytes cultured in 48-well plates. The cocktail strategy (in situ incubation) was used to assess the induction of CYP1A2, CYP2B6, CYP2C9 and CYP3A4 by using the recommended probe substrate, i.e. phenacetin, bupropion, diclofenac ...
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