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Results 451 - 500 of 2118
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Hotchi Junko - - 2012
Aim: Previous studies have revealed that blockade of the renin angiotensin system attenuates plaque vulnerability and reduces cardiovascular events; however, few studies have compared the effects of an angiotensin-converting enzyme inhibitor (ACEI) with an angiotensin receptor blocker (ARB) and evaluated combination therapy. The objective of this study was to compare ...
Rosenkranz Katja - - 2012
Perinatal hypoxic-ischemic brain injury is an important cause of neurological deficits still causing mortality and morbidity in the early period of life. As efficient clinical or pharmaceutical strategies to prevent or reduce the outcome of perinatal hypoxic-ischemic brain damage are limited, the development of new therapies is of utmost importance. ...
Zhu Z-T - - 2012
1. Resibufogenin (1), a major bufadienolide of Chinese medicine Chan Su, had a wide range of pharmacological activities. In present work, the metabolism of 1 in male Sprague-Dawley rats was investigated by identifying the metabolites of resibufogenin excreted in rat bile. 2. Following an oral dose of 60 mg/kg resibufagenin, nine metabolites were ...
Ohnishi Akihiro - - 2012
The aim of this study was to investigate the correlations of severity of osteoarthritis (OA) and serum biomarkers including keratan sulfate (KS), hyaluronic acid (HA), and chondroitin sulfate (CS) 846 epitope. We also investigated the effect of glucosamine and fish collagen peptide (FCP) on OA. OA was induced in 12 ...
Milani Emanuela S - - 2012
Tyrosine phosphorylation plays a fundamental role in mammary gland development. However, the role of specific tyrosine phosphatases in controlling mammary cell fate remains ill defined. We have identified protein tyrosine phosphatase 1B (PTP1B) as an essential regulator of alveologenesis and lactogenesis. PTP1B depletion increased the number of luminal mammary progenitors ...
Belivani Maria - - 2012
Obesity is one of the leading health risk factors worldwide and is associated with several other risk factors and health problems including type 2 diabetes mellitus, cardiovascular disease and malignancies. Current conventional therapeutic strategies for obesity cannot achieve adequate weight control in all patients, so complementary types of treatment are ...
Kristbjornsdottir Oddny K - - 2012
ABSTRACT: BACKGROUND: Limited data is available on sodium (Na) and potassium (K) intake in young children estimated by 24 hour (24h) excretion in urine. The aim was to assess 24h urinary excretion of Na and K in six-year-old children and its relationship with diet quality. METHODS: The study population was ...
Sha Jing-Quan - - 2012
To investigate the influence of a secondary spacer on the resulting structures of POMOFs containing pytz, five new compounds with different dimensionalities, [Cu(5)(2-pytz)(6)(H(2)O)(4)][SiMo(12)O(40)]·3H(2)O (), [Cu(3)(2-pytz)(4)bipy][H(2)SiMo(12)O(40)]·bipy (), [Cu(3)(2-pytz)(2)(bipy)(4)(H(2)O)(6)][H(4)SiW(12)O(40)](2)·6H(2)O (), [Cu(2)(2-pytz)(phen)(OH)](2)[SiW(12)O(40)]·H(2)O (), [Cu(3)(4-pytz)(4)(H(2)O)(4)][H(2)SiW(12)O(40)]·2H(2)O (), were synthesized. When only 2-pytz was employed, compound with a 3D framework was obtained, whereas when the secondary ...
Gowda Charitha - - 2012
We thank Dodge for highlighting the potential environmental factors that may impact food insecurity upstream of the mechanistic pathway between food insecurity and health. Our work demonstrated that food insecurity is associated with C-reactive protein, a marker of inflammation associated with chronic health conditions such as diabetes, hyperlipidemia, and cardiovascular ...
Nafees Asaad Ahmed - - 2012
OBJECTIVES: To determine pattern and predictors for respiratory illnesses and symptoms and lung function among textile workers in Karachi, Pakistan. METHODS: This was a cross-sectional survey of 372 adult male textile workers from the spinning and weaving sections of 15 textile mills from Karachi. Data were collected from November to ...
Herse Florian F Experimental and Clinical Research Center, Lindenberger Weg 80, 13125 Berlin, Germany. - - 2012
Preeclampsia is a multisystem disorder of pregnancy, originating in the placenta. Cytochrome P450 (CYP)-dependent eicosanoids regulate vascular function, inflammation, and angiogenesis, which are mechanistically important in preeclampsia. We performed microarray screening of placenta and decidua (maternal placenta) from 25 preeclamptic women and 23 control subjects. The CYP subfamily 2J polypeptide ...
Melillo Paolo - - 2012
ABSTRACT: BACKGROUND: We evaluated the association between linear standard Heart Rate Variability (HRV) measures and vascular, renal and cardiac target organ damage (TOD). METHODS: A retrospective analysis was performed including 200 patients registered in the Regione Campania network (aged 62.4 +/- 12, male 64%). HRV analysis was performed by 24-h ...
Tirtom Naciye Esma NE Department of Applied Chemistry, School of Engineering, the University of Tokyo, Tokyo 113-8656, - - 2013
V(1)-ATPase is a rotary motor protein that rotates the central shaft in a counterclockwise direction hydrolyzing ATP. Although the ATP-binding process is suggested to be the most critical reaction step for torque generation in F(1)-ATPase (the closest relative of V(1)-ATPase evolutionarily), the role of ATP binding for V(1)-ATPase in torque ...
Soh Siowling - - 2012
The contact electrification of insulating organic polymers is still incompletely understood, in part because multiple fundamental mechanisms may contribute to the movement of charge. This study describes a mechanism previously unreported in the context of contact electrification: that is, "contact de-electrification", a process in which polymers charged to the same ...
Karimi Mohammad Yahya - - 2012
We assessed the association of functional single nucleotide polymorphisms (SNP) in FAS -1377, -670 and FAS ligand (FASL) -844 promoters in 139 oral cancer patients and 126 normal subjects by PCR-RFLP. In logistic regression analysis FAS -1377 GA genotype appeared to marginally increase the risk while FASL -844 TC genotype ...
Felton Luke - - 2012
Abstract The present study aimed to explore the mediating role of social factors on the associations between attachment styles and basic psychological needs satisfaction within two relational contexts. Athletes (N = 215) completed a multi-section questionnaire pertaining to attachment styles, basic needs satisfied within the coaching and the parental relational ...
Cusato Sueli - - 2012
Abstract The present study describes the implementation of a food safety system in a dairy processing plant located in the State of São Paulo, Brazil, and the challenges found during the process. In addition, microbiological indicators have been used to assess system's implementation performance. The steps involved in the implementation ...
Richmond Melanie J - - 2012
This longitudinal study examined how observations of parental general communication style and control with their adolescents predicted changes in negative affect over time for adolescent smokers and nonsmokers. Participants were 9th- and 10th-grade adolescents (N = 111; 56.8% female) who had all experimented with cigarettes and were thus at risk for continued ...
Michael Lewiecki E - - 2012
Suicide is a serious public health concern that is responsible for almost 1 million deaths each year worldwide. It is commonly an impulsive act by a vulnerable individual. The impulsivity of suicide provides opportunities to reduce the risk of suicide by restricting access to lethal means. In the United States, ...
Mesuere Bart - - 2012
The Unipept web application (http://unipept.ugent.be) supports biodiversity analysis of large and complex metaproteome samples using tryptic peptide information obtained from shotgun MS/MS experiments. Its underlying index structure is designed to quickly retrieve all occurrences of a tryptic peptide in UniProtKB records. Taxon-specificity of the tryptic peptide is successively derived from ...
Fritz Jason S JS Department of Medicine, M.S., Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, - - 2013
Hepatopulmonary syndrome and portopulmonary hypertension are two pulmonary vascular complications of liver disease. The pathophysiology underlying each disorder is distinct, but patients with either condition may be limited by dyspnea. A careful evaluation of concomitant symptoms, the physical examination, pulmonary function testing and arterial blood gas analysis, and echocardiographic, imaging, ...
Zhang Lingang - - 2012
VIPP1 protein in photosynthetic organisms is homologous to bacterial PspA, which protects plasma membrane integrity upon stresses. Despite the proposed role of VIPP1 in thylakoid biogenesis, its precise function remains unclear. Recently, our in-depth analysis of Arabidopsis vipp1 mutants revealed VIPP1's involvement in the maintenance of chloroplast envelopes. Chloroplasts in ...
Garcia Ivelitza - - 2012
DEAD-box proteins are believed to participate in the folding of RNA by destabilizing RNA secondary or tertiary structures. Although these proteins bind and hydrolyze ATP, the mechanism for which nucleotide hydrolysis is coupled to helix destabilization may vary among different DEAD-box proteins. To investigate their abilities to disrupt helices and ...
Shum David D High-Throughput Screening Core Facility, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, - - 2013
MicroRNAs (miRNAs) are evolutionary conserved noncoding molecules that regulate gene expression. They influence a number of diverse biological functions, such as development and differentiation. However, their dysregulation has been shown to be associated with disease states, such as cancer. Genes and pathways regulating their biogenesis remain unknown and are highly ...
Menheniott Trevelyan R - - 2012
During the past decade, a new family of stomach-specific proteins has been recognized. Now known as 'gastrokines' (GKNs), these secreted proteins are products of gastric mucous producing cell lineages. GKNs are highly conserved in physical structure and emerging data points to convergent functions in the modulation of gastric mucosal homeostasis ...
Dodson Reuben Blair - - 2013
Fetal intrauterine growth restriction (IUGR) results in increased placental resistance to blood flow, fetal hypertension, and increased pulsatility stresses shown to lead to vascular remodeling. We tested our hypothesis that IUGR causes decreased compliance in the carotid and umbilical arteries due to altered extracellular matrix (ECM) composition and structure. A ...
Chou Wen-Ying Sylvia - - 2012
As Web 2.0 and social media make the communication landscape increasingly participatory, empirical evidence is needed regarding their impact on and utility for health promotion. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched 4 medical and social science databases for literature (2004-present) on the intersection of ...
Ford Judith M JM To whom correspondence should be addressed; Psychiatry Service (116D), San Francisco VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, US; tel: 415-221-4810, ext. 4187, fax: 415-750-6622, e-mail: - - 2013
Predictions about sensations resulting from motor acts are instantiated through neural mechanisms such as the corollary discharge. With each action, the corollary discharge provides an unconscious comparison between predicted and actual sensations resulting from the action; closer matches result in greater suppression of sensation. This mechanism is disrupted in schizophrenia ...
Bradford Natalie - - 2012
We conducted a pilot study to investigate the effectiveness of a home telehealth service for paediatric palliative care consultations. Over a 10 week period, 14 of the 17 caregivers approached to be part of the study agreed to participate. Families were allocated, non-randomly, to a control group (usual care) or ...
Sørensen Jesper G - - 2012
Ecological relevance and repeatability of results obtained in different laboratories are key issues when assessing thermal tolerance of ectotherms. Traditionally assays have used acute exposures to extreme temperatures. The outcomes of ecologically more relevant ramping experiments, however, are dependent on the rate of temperature change leading to uncertainty of the ...
Jiang Weiya W Department of Nutritional Sciences and Toxicology, Graduate Program in Metabolic Biology, University of California, Berkeley, California 94720, - - 2013
Rdh10 catalyzes the first step of all-trans-retinoic acid biogenesis physiologically, conversion of retinol into retinal. We show that Rdh10 associates predominantly with mitochondria/mitochondrial-associated membrane (MAM) in the absence of lipid droplet biosynthesis, but also locates with lipid droplets during acyl ester biosynthesis. Targeting to lipid droplets requires the 32 N-terminal ...
Beck John J - - 2012
The spiroketal (E)-conophthorin has recently been reported as a semiochemical of the navel orangeworm moth, a major insect pest of California pistachios and almonds. Conophthorin and the isomeric spiroketal chalcogran are most commonly known as semiochemicals of several scolytid beetles. Conophthorin is both an insect- and plant-produced semiochemical widely recognized ...
Barber Horacio A HA Department of Cognitive Psychology, University of La Laguna, La Laguna, Spain. - - 2013
During natural reading, parafoveal information is processed to some degree. Although isolated words can be fully processed in the parafovea, not all sentence reading experiments have found evidence of semantic processing in the parafovea. We suggest a possible reconciliation for these mixed results via two ERP studies in which volunteers ...
Sanyal Udishnu - - 2012
A new solid state synthetic route has been developed toward metal and bimetallic alloy nanoparticles from metal salts employing amine-boranes as the reducing agent. During the reduction, amine-borane plays a dual role: acts as a reducing agent and reduces the metal salts to their elemental form and simultaneously generates a ...
Mitani Kaoru - - 2012
Sappanwood (Caesalpinia sappan Linn.) is used as an herbal medicine. It is sometimes used to treat skin damage or as a facial cleanser. In the present study, the methanol (MeOH) extract of sappanwood was found to inhibit melanin synthesis in cultured human melanoma HMV-II cells stimulated with forskolin, and six ...
Muhammad Sohail - - 2012
The displacement of a CO ligand from an unusually labile rhenium carbonyl complex containing a bidentate carboxyaldehyde pyrrolyl ligand by PPh(3) and pyridine has been investigated. The reaction is found to proceed by an associative, preequilibrium mechanism. Theoretical calculations support the experimental data and provide a complete energetic profile for ...
Okamura Daiji - - 2012
Transcription elongation is stimulated by positive transcription elongation factor b (P-TEFb), for which activity is repressed in the 7SK small nuclear ribonucleoprotein (7SK snRNP) complex. We show here a critical role of 7SK snRNP in growth control of primordial germ cells (PGCs). The expression of p15(INK4b), a cyclin-dependent kinase inhibitor ...
Macpherson Cheryl - - 2012
We appreciate Ford's documentation of the many ways in which climate change threatens the traditional lifestyles and health of indigenous and other populations.(1) As Ford states, the impacts of climate change on indigenous peoples are primarily studied in Australia and the Arctic, leaving much unknown about their global scale and ...
Richardson David B - - 2012
OBJECTIVES: Standardised mortality ratios (SMRs) play an important role in the epidemiological literature, particularly in evaluations of occupational hazards. While some authors have argued that comparisons of SMRs should be avoided, many investigators find such analyses appealing particularly when data are sparse. For example, calendar period-specific SMRs often are examined ...
Nomoto Yuichi - - 2012
In Arabidopsis thaliana, the circadian clock regulates the photoperiodic plant growth including the elongation of hypocotyls in a short-days (SDs)-specific manner. The clock-controlled PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) gene encoding a basic helix-loop-helix (bHLH) transcription factor plays crucial roles in this regulation. The SDs-specific elongation of hypocotyls is best explained by ...
Sachidanandam Kamakshi K University of Wisconsin School of Pharmacy, - - 2013
The anthracycline anticancer agent doxorubicin has long been recognized to induce a dose-limiting cardiotoxicity and may be associated with genes relevant to doxorubicin disposition. Recent reports suggest a role for a number of single nucleotide polymorphisms in anthracycline cardiotoxicity in children. We describe two adult sisters with anthracycline cardiotoxicity that ...
Kohn Tertius A - - 2013
This study investigated for the first time maximum force production, shortening velocity (Vmax) and power output in permeabilised single muscle fibres at 12°C from lion, Panthera leo (Linnaeus 1758), and caracal, Caracal caracal (Schreber 1776), and compared the values with those from human cyclists. Additionally, the use and validation of ...
Zhao Jiagang J State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510275, - - 2013
Spinal cord injury (SCI) results in devastating motor and sensory deficits secondary to disrupted neuronal circuits and poor regenerative potential. Efforts to promote regeneration through cell extrinsic and intrinsic manipulations have met with limited success. Stem cells represent an as yet unrealized therapy in SCI. Recently, we identified novel culture ...
Kruse Holger - - 2012
We analyze the error compensations that are responsible for the relatively good performance of the popular B3LYP/6-31G* model chemistry for molecular thermochemistry. We present the B3LYP-gCP-D3/6-31G* scheme, which corrects for missing London dispersion and basis set superposition error (BSSE) in a physically sound manner. Benchmark results for the general main ...
Jung Kwang Hwa - - 2012
Persistent organic pollutants (POPs) are degradation-resistant anthropogenic chemicals that accumulate in the food chain and in adipose tissue, and are among the most hazardous compounds ever synthesized. However, their toxic mechanisms are still undefined. To investigate whether characteristic molecular signatures can discriminate individual POP and provide prediction markers for the ...
Aguilar-Hidalgo Daniel - - 2012
During development, extracellular signaling molecules interact with intracellular gene networks to control the specification, pattern and size of organs. One such signaling molecule is Hedgehog (Hh). Hh is known to act as a morphogen, instructing different fates depending on the distance to its source. However, how Hh, when signaling across ...
Haley Charlotte L - - 2012
AIMS: Catheter ablation for paroxysmal atrial fibrillation (AF) is rapidly becoming a standard practice. There is literature to support that catheter ablation of persistent AF requires additional 'substrate modification'. In clinical practice, operators rely on automated fractionation maps created by three-dimensional anatomic mapping systems to rapidly assess complex 'fractionated' signals ...
Abdelhafez Omaima M - - 2012
New series of 4-methyl and 3,4-dimethyl-7-oxycoumarin derivatives (oxadiazoles, thiadiazoles, triazoles and thiazolidinones) were designed, synthesized and evaluated for their monoamine oxidase (MAO) A and B inhibiting effect. All the synthesized compounds showed in vitro high affinity and selectivity towards MAO-A isoenzyme, compared to clorgyline and moclobemide, with Ki values on ...
Niihori Yoshiki - - 2012
The effect of Pd doping on the ligand-exchange reactivity of Au(25)(SC(12)H(25))(18) was studied by comparing the ligand-exchange reactivity of [Au(25)(SC(12)H(25))(18)](-) and [PdAu(24)(SC(12)H(25))(18)](0) and the results clearly demonstrate that, regardless of the kind of incoming thiols and solvents, Pd doping greatly increases the rate of ligand exchange of Au(25)(SC(12)H(25))(18), indicating an ...
Fineberg Harvey V - - 2012
Public health aims to provide the necessary conditions for a population to be healthy.(1,2) Public health balances such lofty ideals as health, happiness, and productivity with pragmatic problem solving-metaphorically, keeping its head in the clouds and its feet on the ground. Public health attempts to see health problems in their ...
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