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Uchida Natsuko - - 2012
The molecular design, characteristics, and catalytic activity of macrocyclic amino compounds, azacalix[3](2,6)pyridine derivatives, were studied. The introduction of an electron-donating group on the pyridine moiety and bridging amino phenyl group enabled the enhancement of the basicity of azacalix[3](2,6)pyridine up to pKBH+ = 29. 5 in CD3CN. These derivatives were shown ...
Caygill J Sarah - - 2012
Due to the heightened level of national security currently prevalent due to the possibility of terrorist incidents, highly portable, miniaturised and sensitive monitoring devices for trace levels of injurious materials, such as explosives are now of the upmost importance. One method that offers a possible route for the development of ...
El Omar Abdel Karim - - 2012
The decay of solvated electron es- is observed by nanosecond and picosecond pulsed radiolysis, in diluted and highly concentrated solutions of dichloromethane CH2Cl2, trichloromethane CHCl3, tribromomethane CHBr3, acetone CH3COCH3 and nitromethane CH3NO2 prepared in ethylene glycol. First, second order rate constants for the reactions between e-s and the organic scavengers ...
Sanz-Penella Juan Mario - - 2012
Phytase activity was recently described in probiotic bifidobacterial strains, opening the possibilities for their use in foods, due to the generally regarded as safe/qualified presumption of safety status of these bacteria. Two raw materials for infant cereals (multicereal and gluten-free) were examined by measuring the myo-inositol phosphates content and the ...
Telenius Jelena - - 2012
Tear fluid lipid layer (TFLL) residing at the air-water interface of tears has been recognized to play an important role in the development of dry eye syndrome. Yet, the composition, structure, and mechanical properties of TFLL are only partly known. Here, we report results of coarse-grained simulations of a lipid ...
Gsaller Fabio - - 2012
Iron is an essential element for all eukaryotes but its excess has deleterious effects. Aspergillus fumigatus produces extracellular siderophores for iron uptake and the intracellular siderophore ferricrocin (FC) for distribution and storage of iron. Iron excess has previously been shown to increase the content of ferric FC and the expression ...
Famulari Antonino - - 2012
We present the results of a molecular modeling study of several thiophene-based oligomers and polymers by solid state density functional theory (DFT) calculations. In particular, we consider two polymers for which limit-ordered crystal structures have been reported by our group, on the basis of powder X-ray data analysis: poly(3-(S)-2-methylbutylthiophene) (P3MBT) ...
Yanovsky Innesa - - 2012
The cascade of events that occurs in Alzheimer's disease involving oxidative stress and the reduction in cholinergic transmission can be better addressed by multifunctional drugs than cholinesterase inhibitors alone. For this purpose we prepared a large number of derivatives of indoline-3-propionic acids and esters. They showed scavenging activity against different ...
Favelier Sylvain - - 2012
Many routes have been described for percutaneous adrenal gland biopsy. They require either a complex non-axial path or a long hydrodissection or even pass through an organ thereby increasing complications. We describe here an approach using an artificially-induced carbon dioxide (CO(2)) pneumothorax, performed as an outpatient procedure in a 57-year-old ...
Kelly Alexander D R - - 2012
High environmental tungsten levels were identified near the site of a childhood pre-B acute lymphoblastic leukemia (preB-ALL) cluster, however a causal link between tungsten and leukemogenesis has not been established. The major site of tungsten deposition is bone, the site of B cell development. In addition, our in vitro data ...
Alshehri Ah - - 2012
An enhancement in the electrical performance of low temperature screen-printed silver nanoparticles (nAg) has been measured at frequencies up to 220 GHz. We show that for frequencies above 80 GHz the electrical losses in coplanar waveguide structures fabricated using nAg at 350oC are lower than those found in conventional thick ...
Nomura M - - 2012
BackgroundOral mucositis is one of the most common side-effects of 5-fluorouracil (5-FU)-based chemotherapy. The objective of this study was to evaluate the effects of irsogladine maleate (IM) on fluorouracil-induced oral mucositis through a double-blind, placebo controlled trial.Patients and methodsPatients (N = 66) were randomly assigned to receive either placebo or IM (4 mg/day ...
Weide Rudolf - - 2012
ABSTRACT Bendamustine and bendamustine/rituximab-combinations have shown high efficacy in relapsed/refractory chronic lymphocytic leukemia (CLL) and indolent B-cell-malignancies (NHL). No data do exist about bendamustine-retherapy after relapse concerning efficacy and toxicity in this patient population. 88 outpatients (57 patients with CLL, 31 patients with NHL) who previously had been treated with ...
Alam Samiah - - 2012
The protozoan intestinal parasite Giardia lamblia lacks mitochondria and the ability to make haem yet encodes several putative haem-binding proteins, including three of the cytochrome b(5) family. We cloned one of these (gCYTb5-I) and expressed it within Escherichia coli as a soluble holoprotein. UV-visible and resonance Raman spectra of gCYTb5-I ...
Guldberg Rikke - - 2012
INTRODUCTION AND HYPOTHESIS: The aim of this study was to evaluate the impact of urogynecological surgery on quality of life based on patient reported outcome measures (PROMs). METHODS: Data were retrieved from the Danish Urogynaecological Database. Inclusion criteria were Danish women undergoing surgery for urinary incontinence (UI) or pelvic organ ...
He Suqin - - 2012
Androgen ablation therapy represents the first line of therapeutic intervention in men with advanced or recurrent prostate tumors. However, the incomplete efficacy and lack of durable response to this clinical strategy highlights an urgent need for alternative treatment options to improve patient outcomes. Targeting the molecular chaperone heat shock protein ...
Nakayama Masafumi - - 2012
The innate immune system has developed to acquire a wide variety of pattern-recognition receptors (PRRs) to identify potential pathogens, whereas pathogens have also developed to escape host innate immune responses. ITIM-bearing receptors are attractive targets for pathogens to attenuate immune responses against them; however, the in vivo role of the ...
Cabe Patrick A - - 2012
Participants explored ellipse perimeters defined by fixed-length strings, held taut by their moving finger, with ends attached to two fixed hooks (foci). Participants haptically judged ellipse interfocal distance (IFD; in effect, exocentric separation, or size at a distance) or location of ellipse major axes (i.e., egocentric localization relative to the ...
Chen Fenghua - - 2012
Depressive disorders and the treatment thereof have been associated with a number of neuroplastic events, such as neurogenesis and synaptic remodeling in discrete areas of the brain. The associations of these events in changes regarding the energy supply have not been investigated. Here, we investigated changes in mitochondrial plasticity and ...
Dao Kim - - 2012
We report the case of a drug interaction between methotrexate (MTX) and chloral hydrate (CH) observed in a child treated for acute leukemia. Significantly slower MTX clearance and increased MTX exposure occurred on the first three courses of a high-dose chemotherapy when co-administered with CH despite normal renal function, adequate ...
Walker Tobias - - 2012
OBJECTIVES: Serum response factor (SRF), E2F1 and survivin are well-known factors involved in a multitude of cancer-related regulation processes. However, to date, no suitable means has been found to apply their potential in the therapy of non-small cell lung cancer (NSCLC). This study deals with questions of small interfering ribonucleic ...
Imamura H - - 2012
Many of the published data on the lipid profile of athletes is based on studies of endurance athletes. The data on soccer players are rare. The purpose of this study was to examine serum high-density lipoprotein cholesterol subfractions and lecithin:cholesterol acyltransferase activity in collegiate soccer players. 31 well-trained male collegiate ...
Hillaire Marine L B - - 2012
Virus-specific CD8+ T cells contribute to protective immunity against influenza A virus infections. Since the majority of these cells are directed to conserved viral proteins, they may afford protection against influenza A viruses of various subtypes. In the present study, we assessed the cross-reactivity of human CD8+ T lymphocytes, induced ...
Gigault Julien - - 2012
The application of asymmetric-flow field flow fractionation (A4F) for low aspect ratio gold nanorod (GNR) fractionation and characterization was comprehensively investigated. We report on two novel aspects of this application. The first addresses the analytical challenge involved in the fractionation of positively charged nanoparticles by A4F, due to the interaction ...
Flood Karen - - 2012
PURPOSE: To describe the presentation, treatment, and outcomes for 14 patients with aneurysms of the inferior pancreaticoduodenal arteries associated with occlusive lesions of the celiac axis, and to review the literature for similar cases. METHODS: Over a period of 12 years, 14 patients (10 women and 4 men) ranging in age ...
Blay J - - 2012
Mastitis obliterans is an uncommon and late manifestation of ductal ectasia. We report a case of a woman with a long-term type 2 diabetes, referred to us because of a palpable right breast mass. Mammography showed an asymmetry in the palpated area. Ultrasonography was consistent with a an irregular, hypoechoic ...
Samuel Nardin - - 2012
BACKGROUND:Sequencing of cancer genomes has become a pivotal method for uncovering and understanding the deregulated cellular processes driving tumor initiation and progression. Whole-genome sequencing is evolving toward becoming less costly and more feasible on a large scale; consequently, thousands of tumors are being analyzed with these technologies. Interpreting these data ...
Maresca Marcello - - 2012
Custom designed nucleases (CDNs) greatly facilitate genetic engineering by generating a targeted DNA double-strand break (DSB) in the genome. Once a DSB is created, specific modifications can be introduced around the breakage site during its repair by two major DNA damage repair (DDR) mechanisms: the dominant but error-prone non-homologous end ...
Abro Manzoor Ali - - 2012
The influence of nitrogen (N) nutrition on a plant's susceptibility to Botrytis and other pathogens is well documented However, little is known of possible effects on sporulation of the pathogen on diseased tissue and on the pathogenicity of resulting secondary inoculum. To address this question, sporulation by two strains of ...
Sato Kota - - 2012
We recently reported spinal blood flow-metabolism uncoupling in the Cu/Zn-superoxide dismutase 1 (SOD1)-transgenic (Tg) mouse model of amyotrophic lateral sclerosis (ALS), suggesting relative hypoxia in the spinal cord. However, the hypoxic stress sensor pathway in ALS has not been well studied. In the present work, we examined the temporal and ...
Tenga Milagros J - - 2012
The biological processes that unfold during the G1-phase of the cell cycle are dependent on extracellular mitogenic factors which signal the cell to enter a state of quiescence, or commit to a cell cycle round by passing the restriction point (R-point) and enter the S-phase. Unlike normal cells, cancer cells ...
Chung Yongchul - - 2012
Molecular dynamics simulations and energy landscape analyses are carried out to study the atomic mobility of a polymer glass during the physical aging process that follows shear and thermal cycles. The mobility is characterized by the fraction of atoms moving more than its diameter in a given time interval. The ...
Papanikolaou Xenofon - - 2012
ABSTRACT: Extramedullary plasmacytomas constitute a rare and not well studied subset of MM relapses. We report the incidence, clinical-laboratory features and outcome of patients with MM and extramedullary relapse (ExMeR). 303 symptomatic MM patients were recorded in a thirteen years period in two institutions. 28 cases of ExMeR (9%) were ...
Saad Wael E A - - 2012
PURPOSE: This study describes and evaluated the effectiveness of occluding distal ureters in the clinical setting of urinary vaginal (vesicovaginal or enterovesicovaginal) fistulae utilizing a new technique which combines Amplatzer vascular plugs and N-butyl cyanoacrylate. MATERIALS: This is a retrospective study (January 2007-December 2010) of patients with urinary-vaginal fistulae undergoing ...
Taig Efrat - - 2012
We tested cerebellar degeneration in human patients in a task designed to isolate different aspects of motor planning and found a specific relationship between their ability to do inverse kinematic transformation and sparing of Crus I. Our approach was based on an experimental design introduced by Sober and Sabes (2003, ...
Asselah Tarik - - 2012
Hepatitis C Virus (HCV) is a major cause of chronic liver disease worldwide. In addition to viral and environmental behavioral factors, host genetic diversity is believed to contribute to the spectrum of the disease. The sequencing of the human genome, together with the development of high-throughput technologies that measure the ...
Capitanio Selene - - 2012
PURPOSE: The active form of vitamin D (1,25(OH)(2)D) contributes to blood flow regulation in skeletal muscle. The aim of the present study was to determine whether this hormone also modulates coronary physiology, and thus whether abnormalities in its bioavailability contribute to excess cardiovascular risk in patients with disorders of mineral ...
Ford Nikki A - - 2012
Luminal breast tumors with little or no estrogen receptor-α expression confer poor prognosis. Using the Met1 murine model of luminal breast cancer, we characterized the insulin-like growth factor 1 (IGF1)-dependency of diet-induced obesity (DIO) and calorie restriction (CR) effects on tumor growth, growth factor signaling, epithelial-to-mesenchymal transition (EMT) and chemokine ...
El-Dahr Samir S - - 2012
Abstract Gene-environment interactions are implicated in congenital disorders. Accordingly, there is a pressing need to develop animal models of human disease, which are the product of defined gene-environment interactions. Work from our laboratory demonstrates the presence of genetic interactions between the bradykinin B2 receptor (Bdkrb2) and the tumor suppressor protein ...
Behinaein Sepideh - - 2012
494 smelter employees from New Brunswick participated in a bone lead survey conducted by McMaster University in 2008, using the four element "clover-leaf" geometry germanium detector system. The employees were measured at two different bone sites, tibia and calcaneus, each measurement lasting 30 minutes. Scattered photons, including Pb X-rays, were ...
Gélinas Simon - - 2012
We investigate the properties of long-lived species, such as geminate electron-hole pairs, in F8BT films through time-resolved photoluminescence (PL) measurements at room temperature and 10 K. The kinetics consist of an initial exponential decay τ = 2.26 ns) followed by a weak power-law decay (I(t) ∝ t(-1)) up to at ...
Cilan Havva - - 2012
Background: To investigate the relationship between depression, nutritional status, and inflammatory markers in patients on peritoneal dialysis (PD). Patients and Methods: This prospective study included 40 PD patients and 20 healthy people. The severity of depressive symptoms was assessed using the Beck Depression Inventory, the Hamilton Depression Rating Scale, and ...
Plucinska Gabriela - - 2012
Mitochondria provide ATP, maintain calcium homeostasis, and regulate apoptosis. Neurons, due to their size and complex geometry, are particularly dependent on the proper functioning and distribution of mitochondria. Thus disruptions of these organelles and their transport play a central role in a broad range of neurodegenerative diseases. While in vitro ...
Wu Ming-Fang - - 2012
Persistent high fever is one of the most typical clinical symptoms in dengue virus (DV)-infected patients. However, the source of endogenous pyrogen (such as IL-1β) and the signaling cascade leading to the activation of inflammasome and caspase-1, which are essential for IL-1β and IL-18 secretion, during dengue infection have not ...
Fens Manon - - 2012
Background: Patients with transient ischaemic attack (TIA) or minor stroke generally receive, besides secondary prevention, no regular follow up care after discharge directly home from the Emergency Room or TIA outpatient clinic; because it is believed that they will experience no consequences. Objectives: To explore whether the TIA and minor ...
Putzer Daniel - - 2012
PURPOSE: The aim of this study was to evaluate the impact of (68)Ga-labelled DOTA(0)-lanreotide ((68)Ga-DOTA-LAN) on the diagnostic assessment of neuroendocrine tumour (NET) patients with low to moderate uptake on planar somatostatin receptor (SSTR) scintigraphy or (68)Ga-labelled DOTA(0),Tyr(3)-octreotide ((68)Ga-DOTA-TOC) positron emission tomography (PET). METHODS: Fifty-three patients with histologically confirmed NET ...
Angus Scott V - - 2012
Cryptosporidium spp. is an obligate, parasitic protozoan that is difficult to detect and causes diarrhea in healthy adults while potentially causing death in the immunocompromised and children. Its treatment options are few and treat the symptoms, not the actual parasite. Current methods of detection are inefficient and rely too heavily ...
Karle William E - - 2012
BACKGROUND: For patients who have extensive prior treatment, use of the internal mammary artery/vein (IMA/IMV) or cephalic vein has been shown to be a reliable option. Additionally, for those patients who require vascularized bone and extensive soft tissue reconstruction, the combined latissimus dorsi scapular free flap (mega-flap) is an excellent ...
Gage Heather - - 2012
ABSTRACT: BACKGROUND: Older people living in care homes in England have complex health needs due to a range of medical conditions, mental health needs and frailty. Despite an increasing policy expectation that professionals should operate in an integrated way across organisational boundaries, there is a lack of understanding between care ...
Anderson Craig M - - 2012
Hetero-multinuclear, platinum/ruthenium species were synthesized and tested for their effect on the motility of A549 (nonsmall cell lung) and MDA-MB-231 (breast) cancer cells and for their ability to inhibit DNA mobility using gel electrophoresis. It was found that the Ru(2)Pt trinuclear species [Na(2)]{[Ru(III)Cl(4)(DMSO-S)(-μ-pyz)](2)Pt(II)Cl(2)}, AH197, was much more efficient at inhibiting ...
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