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Yalin Ayse Serap - - 2012
Calciphylaxis is usually a fatal condition that develops in a few chronic renal failure patients, and it is characterized by calcifications in subcutaneous arteries, infarcts in skin, and the neighboring subcutis. Calciphylaxis, once considered as a rare condition, has been reported to have an annual incidence of 1% and a ...
Kozubal Mark A MA Department of Land Resources and Environmental Sciences and Thermal Biology Institute, Montana State University, Bozeman, MT 59717, - - 2013
Geothermal systems in Yellowstone National Park (YNP) provide an outstanding opportunity to understand the origin and evolution of metabolic processes necessary for life in extreme environments including low pH, high temperature, low oxygen and elevated concentrations of reduced iron. Previous phylogenetic studies of acidic ferric iron mats from YNP have ...
Shah Dhaval K - - 2012
To build a multiscale mechanism based pharmacokinetic-pharmacodynamic (PK/PD) model for antibody drug conjugates (ADCs), using brentuximab-vedotin as an example, for preclinical to clinical translation of ADC efficacy. Brentuximab-vedotin experimental data, collected from diverse publications, were employed in the following steps to build and validate the model: (1) characterization of ADC ...
Cataldi M P MP Molecular, Cellular and Developmental Biology Program, The Ohio State University, Columbus, OH, - - 2013
The palindromic terminal repeats (TRs) of adeno-associated virus (AAV) form DNA hairpins (HPs) are essential for replication and for priming the conversion of single-stranded virion DNA to double strand. In recombinant AAV (rAAV) gene-delivery vectors, they are targets for the DNA-repair pathways leading to circularization, concatemerization and, infrequently, chromosomal integration. ...
Di Rosa Michelino - - 2012
Macrophages as a principal component of immune system play an important role in the initiation, modulation, and final activation of the immune response against pathogens. Upon stimulation with different cytokines, macrophages can undergo classical or alternative activation to become M1 or M2 macrophages, which have different functions during infections. Although ...
Hornuss Cyrill - - 2012
Human breath contains an abundance of volatile organic compounds (VOCs). Analysis of breath VOC may be used for diagnosis of various diseases or for on-line monitoring in anesthesia and intensive care. However, VOC concentrations largely depend on the breath sampling method and have a large inter-individual variability. For the development ...
Gingras Marc - - 2012
Carbohelicenes are a class of fascinating chiral helical molecules which have a rich history in chemistry. Over a period of almost 100 years, chemists have developed many methods to prepare them in a racemic or in a non-racemic form. They also possess a series of interesting chiral, physical, electronic and ...
Bass Joseph - - 2012
Biological clocks are genetically encoded oscillators that allow organisms to anticipate changes in the light-dark environment that are tied to the rotation of Earth. Clocks enhance fitness and growth in prokaryotes, and they are expressed throughout the central nervous system and peripheral tissues of multicelled organisms in which they influence ...
Wansink Brian - - 2012
OBJECTIVE: Although most parents know that vegetables are healthful, vegetables are served at only 23 % of American dinners. If added nutrition is not a sufficient motivation, might a parent be more inspired to serve vegetables if doing so improved either the taste of the entrée or how loving and ...
Barbana Chockry - - 2012
The chemical composition of whole lentil flours and lentil protein concentrates prepared by alkaline extraction and iso-electric precipitation from Blaze and Laird varieties of lentil were studied. The protein composition of the flours and concentrates, determined by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and size-exclusion high-performance liquid chromatography (SE-HPLC) ...
Dalu John David - - 2012
Results show that the year-to-year quality variation of wines produced in North and Central Italy depends on the large-scale climate variability, and that the wine quality improvement in the last four decades is partially due to an increase of temperature and to a decrease of precipitation in West and Central ...
Kaur Rupinder - - 2012
The aim of present study was to evaluate the effect of aqueous leaf extract of Annona squamosa with Glipizide in a high fat diet and streptozocin-induced type-2 diabetes. Nine groups (n = 6) of male Sprague-Dawley rats were used for the study, with. Basal blood glucose, urine volume, and body weights were ...
Esimbekova E N - - 2012
A bioluminescent rapid method was developed to estimate the integral toxicity of natural and wastewater. This method is based on registering the effect of the polluted water sample on the parameters of the bioluminescent reaction catalyzed by the multi-component reagent containing NADH:FMN oxidoreductase, luciferase, and their substrates co-immobilized in a ...
Kortekaas Minke C - - 2012
The propagation time of arterial pulse waves provides information about arterial stiffness. Pulse arrival time (PAT) is calculated as the time between the R-wave (ECG) and three reference points on photoplethysmographic (PPG) pulse waves: foot, first derivative and peak. Because large variation in PAT-values between patients exists, measurements of the ...
Petersen Jens - - 2012
In stream water xenobiotics usually occur as pulses in connection with floods caused by surface run-off and tile drainage following precipitation events. In streams located in small agricultural catchments we monitored herbicide concentrations during flood events by applying an intensive sampling programme of ½ h intervals for 7 h. In ...
Allers Elke - - 2012
Marine Group A (MGA) is a candidate phylum of Bacteria that is ubiquitous and abundant in the ocean. Despite being prevalent, the structural and functional properties of MGA populations remain poorly constrained. Here, we quantified MGA diversity and population structure in relation to nutrients and O(2) concentrations in the oxygen ...
Mussino Francesca - - 2012
The possibility to cryopreserve cells allows for wide opportunities of flexible handling of cell cultures from different sponge species. Primmorphs model, a multicellular 3D aggregate formed by dissociated sponge cells, is considered one of the best approaches to establish sponge cell culture but, in spite of the available protocols for ...
Kotnis Nikhil - - 2012
We present an unusual case of a chordoma presenting as an extradural spinal tumour with extension through an expanded intervertebral foramen to form a large paraspinal mass. The magnetic resonance imaging appearances closely mimicked a neurofibroma; however, pre-operative biopsy confirmed the diagnosis of chordoma. This is, to our knowledge, the ...
Rigét Frank - - 2012
Temporal trends of mercury in livers of ringed seals collected from the early 1980s to 2010 from central West, Northwest and central East Greenland were studied. In this period the climate of Greenland warmed and the influences of climate indices such as ice coverage, water temperature and the Atlantic Oscillation ...
Saito Yoshinobu - - 2012
Molecular targeted drugs have become the mainstream for cancer therapy, and they have contributed to improving the outcome for cancer patients. On the other hand, molecular targeted drugs are associated with a variety of adverse drug reactions. Drug-induced interstitial lung disease (DILD) is a typical adverse drug reaction that has ...
Torrens George Edward - - 2012
The purpose of the study was the assessment of preferences for four types of assistive technology (AT) domestic cutlery with 24 female and 10 male participants who had a range of upper limb impairments. A mixed-methods methodology, that included a paired comparisons analysis, was used to inform product development. Qualitative ...
Lee H-S - - 2012
We examined major trends and patterns regarding sodium and potassium intake and the ratio of sodium and potassium in the diets of South Koreans. We used data from 24-h dietary recall data from 10 267, 8819 and 9264 subjects ages 2 years in the 1998, 2005 and 2009 Korean National Health ...
Götze Jens - - 2012
Cathodoluminescence (CL) microscopy and spectroscopy are luminescence techniques with widespread applications in geosciences. Many rock-forming and accessory minerals show CL characteristics, which can be successfully used in geoscientific research. One of the most spectacular applications is the visualization of growth textures and other internal structures that are not discernable with ...
Bilgiç Reyhan - - 2012
The purpose of this study is to examine the major determinants of psychological health during unemployment. With this in mind, 438 (17% female and 83% male) unemployed individuals were contacted through Turkey's State Employment Office. It was expected that the relationship between duration of unemployment and psychological wellbeing would be ...
Mottahedin Amin - - 2012
NF-κB, a family of transcription factors involved in different cell functions and immune responses is targeted by viruses. The mechanism of NF-κB signalling and its role in replication of EAV have not been investigated. We demonstrate that EAV infection in BHK-21 cells activates NF-κB, and this activation was found to ...
Domínguez José M - - 2012
To the Editor: Alexander et al. (Aug. 23 issue)(1) report findings from a prospective, multicenter gene-expression classifier validation study that raises several questions. For the 265 indeterminate fine-needle aspirates they tested, the gene-expression classifier had a sensitivity of 92%, a specificity of 52%, a positive predictive value of 47%, and ...
Kaptijn Ralf - - 2012
Summary This study tests two evolutionary hypotheses on grandparental investments differentiated by the child's sex: the paternity uncertainty hypothesis and the Trivers-Willard hypothesis. Data are from two culturally different countries: the Dutch Longitudinal Aging Study Amsterdam (n=2375) and the Chinese Anhui Survey (n=4026). In the Netherlands, grandparental investments are biased ...
Lucas-Carrasco Ramona - - 2012
ABSTRACT Background: As ageing is a personal experience, an attitude to ageing questionnaire is essential for capturing the most realistic appraisal of this important stage of life. Our aim was to study the psychometric properties of the Attitudes to Ageing Questionnaire (AAQ) in a sample of Spanish older people. Methods: ...
Akelma Ahmet Zülfikar - - 2012
Background: There are no studies on clinically significant transaminase elevation due to rotavirus gastroenteritis in the literature. Also, there are significant discrepancies among previous studies regarding the prevalence of increased serum transaminase levels in rotavirus infection. Methods: Patients investigated for rotavirus by stool antigen testing, who were followed between January ...
Girotra Saket S University of Iowa Hospitals and Clinics, Department of Internal Medicine, Division of Cardiovascular Diseases, 200 Hawkins Dr., Suite 4430 RCP, Iowa City, IA 52242, USA. - - 2012
Despite advances in resuscitation care in recent years, it is not clear whether survival and neurologic function after in-hospital cardiac arrest have improved over time. We identified all adults who had an in-hospital cardiac arrest at 374 hospitals in the Get with the Guidelines-Resuscitation registry between 2000 and 2009. Using ...
Yang Zhou Z Jiangsu Province Key Laboratory for Biodiversity and Biotechnology, School of Biological Sciences, Nanjing Normal University, Nanjing, Jiangsu, China. - - 2013
We use strains recently collected from the field to establish cultures; then, through laboratory studies we investigate how among strain variation in protozoan ingestion and growth rates influences population dynamics and intraspecific competition. We focused on the impact of changing temperature because of its well-established effects on protozoan rates and ...
Pascoal P M PM Faculty of Psychology, University of Lisbon, Lisbon, Portugal. - - 2013
This study investigates the association between variables related to individual body appearance and relationship variables with sexual satisfaction (SS) in a sample of men and women with sexual arousal problems (SAP). An anonymous cross-sectional survey was conducted in a clinical setting with a non-representative sample of people diagnosed (DSP) with ...
Groenen Martien A M MA Animal Breeding and Genomics Centre, Wageningen University, De Elst 1, 6708 WD, Wageningen, The Netherlands. - - 2012
For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the ...
Greene Barry R - - 2012
Falls are the most common cause of injury and hospitalization and one of the principal causes of death and disability in older adults worldwide. Measures of postural stability have been associated with the incidence of falls in older adults. The aim of this study was to develop a model that ...
García-Bajos Elvira - - 2012
Using the retrieval-practice paradigm, we examined the effects of script and selective retrieval on the recall of high- and low-typicality actions of everyday activities. The participants studied two activities, Getting up in the morning and Going to a restaurant, each consisting of high-typicality and low-typicality actions. They then practised half ...
Gangadhar Tara C TC Department of Medicine, Section of Hematology/Oncology, The University of Chicago, 5841 S. Maryland Ave., MC2115, Chicago, IL, 60637, - - 2013
Src kinases are activated in melanoma, and inhibition of Src kinase activity has pre-clinical anti-tumor effects. Targeting this pathway could therefore have therapeutic activity in patients with metastatic melanoma. We conducted a multi-center, open-label study of the Src kinase inhibitor saracatanib (AZD0530) in patients with metastatic melanoma. Twenty-three patients received ...
Nadelman Robert B - - 2012
Erythema migrans is the most common manifestation of Lyme disease. Recurrences are not uncommon, and although they are usually attributed to reinfection rather than relapse of the original infection, this remains somewhat controversial. We used molecular typing of Borrelia burgdorferi isolates obtained from patients with culture-confirmed episodes of erythema migrans ...
da Cunha Leandro Rodrigues - - 2012
Breast milk samples collected from 18 nursing mothers between the 15th and 90th day of lactation were digested in nitric acid in a microwave, and total mercury (THg) levels were quantified by atomic fluorescence spectrometry. Participants responded to a 24-h dietary recall questionnaire on the 74th and 76th day of ...
Bassetti Matteo - - 2012
ABSTRACT: INTRODUCTION: An online survey was conducted to characterize current infection management practices in Italian intensive care units (ICUs), including the antibacterial and antifungal drug regimens prescribed for various types of infections. METHODS: During February-March 2011, all 450 ICUs in public hospitals in Italy were invited to take part in ...
Costa Santini Cristina - - 2012
We implement a finite state machine by representing state, transition rules and input symbols with DNA components. Transitions between states are triggered by a clock signal which allows synchronized, parallel operation of two (or more) state machines. The state machine can be re-programmed by changing the input symbols.
Liang Yung-He - - 2012
A new core-shell nanostructure consisting of inorganic hydroxyapatite (HAP) nanoparticles as the core and organic alginate as the shell (denoted as HAP@Alg) was successfully synthesized by a pre-gel method and applied to pH-responsive drug delivery systems (DDS). HAP@Alg nanoparticles have the advantages of hydroxyapatite and alginate, where hydroxyapatite provides pH-responsive ...
Du Jie - - 2012
A cationic copolymer triggered dimerization of a self-complementary stem-loop DNA. The dimerization was faster than spontaneous dissociation of the dimer. Reversible transformation between stem-loop and dimer structures was driven by switching on/off copolymer activity.
Luo Chonglin - - 2012
MicroRNAs are small noncoding RNAs that regulate gene expression and have important roles in various types of cancer. Previously, miR-137 was reported to act as a tumor suppressor in different cancers, including malignant melanoma. In this study, we show that low miR-137 expression is correlated with poor survival in stage ...
Sole Sushant S - - 2012
Context: Tamarindus indica L. (Leguminosae) is widely used as a traditional medicine for the management of diabetes mellitus (DM) in India, in addition to its anti-inflammatory activity. The present study has been designed to understand the correlation involved between antidiabetic and anti-inflammatory action of aqueous seed extract of T. indica ...
Singla Amit - - 2012
BACKGROUND: Coil embolization has gained importance in the management of intracranial aneurysms over the past decade. However, the recurrence risk after embolization mandates closer follow-up than surgical clip ligation. Currently, there is no reliable system for predicting aneurysm sac thrombosis. An aneurysm embolization grade (AEG) reported previously by the senior ...
Sugie Tomoharu T Department of Surgery, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, - - 2013
Human γδ T cells display potent cytotoxicity against various tumor cells pretreated with zoledronic acid (Zol). Zol has shown benefits when added to adjuvant endocrine therapy for patients with early-stage breast cancer or to standard chemotherapy for patients with multiple myeloma. Although γδ T cells may contribute to this additive ...
Cantekin Işin - - 2012
Background: This study was designed as a pretest-posttest control group experiment. The aim was to identify the influence of music therapy on the perceived stressors and anxiety levels of hemodialysis (HD) patients. Methods: The data were collected in HD Units of Ataturk University Yakutiye Research Hospital and Regional Education, Application ...
Bennett Blake A - - 2012
Context: Ambient particulate matter (PM) is associated with acute exacerbations of airflow obstruction. Additionally, elderly individuals are more susceptible to increased functional morbidity following acute PM exposure. Objective: The purpose of this study is to determine the aging effects of PM exposure on the responsiveness of airway smooth muscle in ...
Wiseman Sam - - 2012
To the Editor: Alexander et al. (Aug. 23 issue)(1) report findings from a prospective, multicenter gene-expression classifier validation study that raises several questions. For the 265 indeterminate fine-needle aspirates they tested, the gene-expression classifier had a sensitivity of 92%, a specificity of 52%, a positive predictive value of 47%, and ...
Tamayo Javier - - 2012
The advances in micro- and nanofabrication technologies enable the preparation of increasingly smaller mechanical transducers capable of detecting the forces, motion, mechanical properties and masses that emerge in biomolecular interactions and fundamental biological processes. Thus, biosensors based on nanomechanical systems have gained considerable relevance in the last decade. This review ...
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