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Results 201 - 250 of 1756
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Akaike Gensuke - - 2012
Extramammary Paget's disease (EMPD) is a rare cutaneous neoplasm that is thought to represent intraepithelial adenocarcinoma developing in an area rich in apocrine glands. Magnetic resonance imaging (MRI) findings for this disease are not well established. We report three cases of pathologically confirmed EMPD in which MRI was performed before ...
Wei Cui - - 2012
The aminobenzo[a]quinolizines were investigated as a novel class of DPP-IV inhibitors. The stereochemistry of this class plays an important role in the bioactivity. In this study, the mechanisms of how different configuration of three chiral centers of this class influences the binding affinity were investigated by molecular dynamics simulations, free ...
Sheffield Justin - - 2012
Drought is expected to increase in frequency and severity in the future as a result of climate change, mainly as a consequence of decreases in regional precipitation but also because of increasing evaporation driven by global warming. Previous assessments of historic changes in drought over the late twentieth and early ...
Akelma Ahmet Zülfikar - - 2012
Background: There are no studies on clinically significant transaminase elevation due to rotavirus gastroenteritis in the literature. Also, there are significant discrepancies among previous studies regarding the prevalence of increased serum transaminase levels in rotavirus infection. Methods: Patients investigated for rotavirus by stool antigen testing, who were followed between January ...
Greene Barry R - - 2012
Falls are the most common cause of injury and hospitalization and one of the principal causes of death and disability in older adults worldwide. Measures of postural stability have been associated with the incidence of falls in older adults. The aim of this study was to develop a model that ...
Dalu John David - - 2012
Results show that the year-to-year quality variation of wines produced in North and Central Italy depends on the large-scale climate variability, and that the wine quality improvement in the last four decades is partially due to an increase of temperature and to a decrease of precipitation in West and Central ...
Kaur Rupinder - - 2012
The aim of present study was to evaluate the effect of aqueous leaf extract of Annona squamosa with Glipizide in a high fat diet and streptozocin-induced type-2 diabetes. Nine groups (n = 6) of male Sprague-Dawley rats were used for the study, with. Basal blood glucose, urine volume, and body weights were ...
Esimbekova E N - - 2012
A bioluminescent rapid method was developed to estimate the integral toxicity of natural and wastewater. This method is based on registering the effect of the polluted water sample on the parameters of the bioluminescent reaction catalyzed by the multi-component reagent containing NADH:FMN oxidoreductase, luciferase, and their substrates co-immobilized in a ...
Kortekaas Minke C - - 2012
The propagation time of arterial pulse waves provides information about arterial stiffness. Pulse arrival time (PAT) is calculated as the time between the R-wave (ECG) and three reference points on photoplethysmographic (PPG) pulse waves: foot, first derivative and peak. Because large variation in PAT-values between patients exists, measurements of the ...
Lin Jinshun - - 2012
A novel approach to synthesize RITA by practical palladium-catalyzed C-C bond-forming Suzuki reactions at room temperature was developed, which was used for deriving a series of substituted tricyclic α-heteroaryl (furan/thiophene) analogues of RITA under mild conditions. These novel analogues showed notable antiproliferative activity against cancer cell lines with wild-type p53 ...
Galal Ahmed M - - 2012
This paper presents a comparative study of anatomy of leaves, stems and roots of three species of Plumbago, namely P. auriculata Lam., P. indica L. and P. zeylanica L. by light microscopy. The paper also provides qualitative and quantitative analysis of the naphthoquinone, plumbagin-a major constituent present in these species-using ...
Körner Mirjam - - 2012
For implementation of patient-centered treatment in interprofessional health care units, such as rehabilitation teams, external participation (interaction between patient and health care professionals) and internal participation (communication, coordination and cooperation in the interprofessional team) need to be considered. The aim of this study is to identify the preferences of patients ...
Cennamo Vincenzo - - 2012
PURPOSE: Surgical decompression is the traditional treatment for acute colorectal cancer obstruction. In recent years, colorectal stenting has been used to relieve the obstruction. This study used meta-analytic techniques to compare colonic stenting versus surgical decompression for colorectal cancer obstruction. METHODS: A comprehensive search of several databases was conducted. The ...
Isik Metin - - 2012
The mainstay of RA treatment is the disease-modifying antirheumatic drugs, and triple DMARD combination is now known to be better than monotherapies. Our aim in this trial was to report our clinical experience with triple DMARD therapy for resistant rheumatoid arthritis. Data of 140 patients with RA resistant to methotrexate ...
Cantekin I┼čin - - 2012
Background: This study was designed as a pretest-posttest control group experiment. The aim was to identify the influence of music therapy on the perceived stressors and anxiety levels of hemodialysis (HD) patients. Methods: The data were collected in HD Units of Ataturk University Yakutiye Research Hospital and Regional Education, Application ...
Bennett Blake A - - 2012
Context: Ambient particulate matter (PM) is associated with acute exacerbations of airflow obstruction. Additionally, elderly individuals are more susceptible to increased functional morbidity following acute PM exposure. Objective: The purpose of this study is to determine the aging effects of PM exposure on the responsiveness of airway smooth muscle in ...
Wiseman Sam - - 2012
To the Editor: Alexander et al. (Aug. 23 issue)(1) report findings from a prospective, multicenter gene-expression classifier validation study that raises several questions. For the 265 indeterminate fine-needle aspirates they tested, the gene-expression classifier had a sensitivity of 92%, a specificity of 52%, a positive predictive value of 47%, and ...
Tamayo Javier - - 2012
The advances in micro- and nanofabrication technologies enable the preparation of increasingly smaller mechanical transducers capable of detecting the forces, motion, mechanical properties and masses that emerge in biomolecular interactions and fundamental biological processes. Thus, biosensors based on nanomechanical systems have gained considerable relevance in the last decade. This review ...
Mottahedin Amin - - 2012
NF-κB, a family of transcription factors involved in different cell functions and immune responses is targeted by viruses. The mechanism of NF-κB signalling and its role in replication of EAV have not been investigated. We demonstrate that EAV infection in BHK-21 cells activates NF-κB, and this activation was found to ...
Domínguez José M - - 2012
To the Editor: Alexander et al. (Aug. 23 issue)(1) report findings from a prospective, multicenter gene-expression classifier validation study that raises several questions. For the 265 indeterminate fine-needle aspirates they tested, the gene-expression classifier had a sensitivity of 92%, a specificity of 52%, a positive predictive value of 47%, and ...
Kaptijn Ralf - - 2012
Summary This study tests two evolutionary hypotheses on grandparental investments differentiated by the child's sex: the paternity uncertainty hypothesis and the Trivers-Willard hypothesis. Data are from two culturally different countries: the Dutch Longitudinal Aging Study Amsterdam (n=2375) and the Chinese Anhui Survey (n=4026). In the Netherlands, grandparental investments are biased ...
Lucas-Carrasco Ramona - - 2012
ABSTRACT Background: As ageing is a personal experience, an attitude to ageing questionnaire is essential for capturing the most realistic appraisal of this important stage of life. Our aim was to study the psychometric properties of the Attitudes to Ageing Questionnaire (AAQ) in a sample of Spanish older people. Methods: ...
Patra Tuhin - - 2012
Nickel catalyzed decyanation of aryl and aliphatic cyanides with hydrosilane as the hydride source has been developed. This method is easy to handle, scalable and can be carried out without a glove box. The method has been applied in the cyanide directed functionalization reaction and α-substitution of benzyl cyanide.
Pandey Meenu - - 2012
Hyponatremic hypertensive syndrome (HHS) is an uncommon disorder, in which hypertension is associated with profound hyponatremia. It is mostly encountered in adults with unilateral renal artery stenosis. Although renovascular hypertension is one of the commonest causes for severe hypertension in children, HHS is rarely reported in childhood. The authors report ...
Gao Yueyi - - 2012
Porcine epidemic diarrhea virus (PEDV) is the causative agent of porcine epidemic diarrhea (PED), which is characterized by severe diarrhea, dehydration and high mortality in the affected pigs. Recently, clinical outbreaks of diarrhea in suckling piglets emerged in pig-producing areas of China. In this study, molecular detection of PEDV was ...
Gingras Marc - - 2012
Carbohelicenes generally incorporate a helical, distorted, conjugated, polyaromatic system with ortho-fused benzenoid rings, which is a fundamental molecular characteristic of this class of compounds. They have been described as "molecules in distress" due to their distortion. The generation of a chiral helicity in helicenes was observed because of a severe ...
Mussino Francesca - - 2012
The possibility to cryopreserve cells allows for wide opportunities of flexible handling of cell cultures from different sponge species. Primmorphs model, a multicellular 3D aggregate formed by dissociated sponge cells, is considered one of the best approaches to establish sponge cell culture but, in spite of the available protocols for ...
Kotnis Nikhil - - 2012
We present an unusual case of a chordoma presenting as an extradural spinal tumour with extension through an expanded intervertebral foramen to form a large paraspinal mass. The magnetic resonance imaging appearances closely mimicked a neurofibroma; however, pre-operative biopsy confirmed the diagnosis of chordoma. This is, to our knowledge, the ...
Rigét Frank - - 2012
Temporal trends of mercury in livers of ringed seals collected from the early 1980s to 2010 from central West, Northwest and central East Greenland were studied. In this period the climate of Greenland warmed and the influences of climate indices such as ice coverage, water temperature and the Atlantic Oscillation ...
Saito Yoshinobu - - 2012
Molecular targeted drugs have become the mainstream for cancer therapy, and they have contributed to improving the outcome for cancer patients. On the other hand, molecular targeted drugs are associated with a variety of adverse drug reactions. Drug-induced interstitial lung disease (DILD) is a typical adverse drug reaction that has ...
- - 2012
To the Editor: In their Perspective article, Basu and Hassenplug (Aug. 9 issue)(1) claim that the time required for patients to gain access to high-risk medical devices is roughly similar in the United States and the European Union. However, the authors do not consider in their estimates the development time ...
Takata Ryo - - 2012
Tamsulosin hydrochloride is one of the most potent drugs for treatment of benign prostatic hyperplasia (BPH), however, the efficacy of tamsulosin hydrochloride varies among individuals. In this study, we measured the maximum serum concentration (Cmax) of tamsulosin hydrochloride in 182 of BPH patients and found remarkable individual variability. To investigate ...
Wang Yin-Hua - - 2012
PURPOSE: Reactivation of hepatitis B virus (HBV) is a common complication in patients with HBV infection who receive cytotoxic chemotherapy. In rituximab-containing chemotherapy for B-cell lymphoma, severe hepatitis due to HBV reactivation occurred. The aim of this study is to estimate the effect of prophylactic lamivudine on the risk of ...
Gisle Lydia - - 2012
PURPOSE: We aimed to estimate the prevalence of suicidal behaviours, i.e. ideation and attempt, in the adult population of Belgium, and to explore their association with household composition. METHODS: Data of 4,459 adults (25-64 years) from the 2004 Belgian Health Interview Survey were used for analyses. Bivariate and multivariate logistic regressions ...
Jenkins Nathaniel D M - - 2012
Abstract We compared starters and non-starters for various isokinetic strength variables in elite women's soccer players. A convenience sample of 10 starters (mean ± s; age = 20 ± 2 years; height = 170 ± 4 cm; body mass = 65 ± 5 kg) and 7 non-starters (age = 20 ± 1 years; height = 164 ± 3 cm; body mass = 63 ± 4 kg) performed maximal voluntary muscle actions of the leg extensors (concentric) and flexors (eccentric) on ...
Saadat Mostafa - - 2012
Summary The prevalence of consanguinity in eight provinces of Afghanistan has recently been reported by Saify & Saadat (2012). The present cross-sectional study was done in order to illustrate the prevalence and types of consanguineous marriages among other populations of Afghanistan. Data on types of marriages were collected using a ...
Kim Chang Seong - - 2012
ABSTRACT: BACKGROUND: Sjogren's syndrome is a systemic autoimmune disease in which lymphatic cells destroy the salivary and lacrimal glands. Glomerulonephritis is thought to be a rare occurrence in primary Sjogren's syndrome. Furthermore, concurrent glomerular involvement and lymphoma in patients with Sjogren's syndrome has seldom been reported. CASE PRESENTATION: A 52-year-old ...
Haapakoski Rita - - 2012
Toll-like receptors (TLRs) are pattern-recognition receptors that have a pivotal role as primary sensors of microbial products and as initiators of innate and adaptive immune responses. We investigated the role of TLR2, TLR3, and TLR4 activation during cutaneous allergen sensitization in the modulation of allergic asthma. The results show that ...
Nicholson Jeremy K - - 2012
Metabolic phenotyping involves the comprehensive analysis of biological fluids or tissue samples. This analysis allows biochemical classification of a person's physiological or pathological states that relate to disease diagnosis or prognosis at the individual level and to disease risk factors at the population level. These approaches are currently being implemented ...
Chen S - - 2012
It has been proposed that thymosin beta 4 (TB4)-protein delivery stimulates differentiation of resident adult WT1-positive cardiac progenitor cells, but with very low efficiency. We determined whether gene therapy with human TB4 stimulates proliferation of resident adult cardiac progenitor cells in normal rat heart. Ultrasound-targeted microbubble destruction (UTMD) was used ...
Petersen Jens - - 2012
In stream water xenobiotics usually occur as pulses in connection with floods caused by surface run-off and tile drainage following precipitation events. In streams located in small agricultural catchments we monitored herbicide concentrations during flood events by applying an intensive sampling programme of ½ h intervals for 7 h. In ...
Allers Elke - - 2012
Marine Group A (MGA) is a candidate phylum of Bacteria that is ubiquitous and abundant in the ocean. Despite being prevalent, the structural and functional properties of MGA populations remain poorly constrained. Here, we quantified MGA diversity and population structure in relation to nutrients and O(2) concentrations in the oxygen ...
Berenson James R - - 2012
Bendamustine, active in multiple myeloma (MM), is a bifunctional mechlorethamine derivative with alkylating properties. Bortezomib, approved to treat MM, is effective in combination with alkylators. The tolerability and efficacy of bendamustine plus bortezomib in relapsed/refractory MM was assessed in an open-label, dose-escalating, phase I/II study. Patients aged ≥18 years received intravenous ...
Huang Jingyu - - 2012
Soil management significantly affects the soil labile organic factors. Understanding carbon and nitrogen dynamics is extremely helpful in conducting research on active carbon and nitrogen components for different kinds of soil management. In this paper, we examined the changes in microbial biomass carbon (MBC), microbial biomass nitrogen (MBN), dissolved organic ...
Larsen Ole H - - 2012
Haemostatic treatment modalities alternative to platelet transfusion are desirable to control serious acute bleeds in primary immune thrombocytopenia (ITP). This study challenged the hypothesis that recombinant activated factor VII (rFVIIa) combined with fibrinogen concentrate may correct whole blood (WB) clot formation in ITP. Blood from ITP patients (n = 12) was drawn ...
Bhalla M - - 2012
It is not known whether serum potassium levels affect blood pressure response to antihypertensive medication. The African American Study of Kidney Disease and Hypertension (AASK) Genomics Study (N=828) is a subset of the AASK trial that randomized 1094 African American men and women with hypertensive nephrosclerosis to ramipril, amlodipine or ...
Gao W B - - 2012
Entanglement has a central role in fundamental tests of quantum mechanics as well as in the burgeoning field of quantum information processing. Particularly in the context of quantum networks and communication, a main challenge is the efficient generation of entanglement between stationary (spin) and propagating (photon) quantum bits. Here we ...
Ettelaie C - - 2012
The role of tissue factor (TF)-containing microparticles in clot propagation has been established, but the ability of circulating microparticles to initiate coagulation has been disputed. However, TF-bearing microparticles, particularly endothelial-microparticles generated during disease, may interact with extracellular matrices which in turn can localise circulating TF to sites of injury. In ...
Gingras Marc - - 2012
Carbohelicenes belong to a class of fascinating, chiral, and helicoidal molecules, which have a rich history in chemistry since the very beginning of the 20th century. A renewed interest in polyaromatic chemistry and new synthetic challenges toward the search for innovative physical, biological, chemical and opto-electronic properties have brought high ...
van Tienen Carla - - 2012
To the Editor: Esbjörnsson and colleagues (July 19 issue)(1) conclude that infection with human immunodeficiency virus type 2 (HIV-2) attenuates the course of HIV-1 infection. Their report raises three issues. First, in Guinea-Bissau, up to 30% of persons infected with both HIV-1 and HIV-2 have coinfection with human T-cell lymphotropic ...
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