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Chowdhury Sumit - - 2012
Glycoprotein D (gD) and glycoprotein I (gI) genes of bovine herpes virus 1 (BHV1) are contiguous genes with 141 bp region between the two open reading frames (ORFs). Expression of gD and gI from a bicistronic construct containing complete gD and gI gene has been reported either through internal ribosome ...
Mimica Marcelo J - - 2012
Methicillin-resistant Staphylococcus aureus (MRSA) are now a worldwide problem. Cystic fibrosis (CF) patients are commonly colonized and infected by MRSA. Accurate oxacillin susceptibility testing is mandatory for the adequate management of these patients. We performed a comparison of the accuracy of different tests in CF isolates, including methicillin-susceptible S. aureus ...
Morais Sirlei Antunes - - 2012
Culex quinquefasciatus is a vector of human pathogens, including filarial nematodes and several viruses. Although its epidemiological relevance is known to vary across geographical regions, an understanding of its population genetic structure is still incipient. In light of this, we evaluated the genetic diversity of Cx. quinquefasciatus and Cx. pipiens ...
Shukla Krupa K Department of Neurology and Brain Science Institute, Johns Hopkins University, Baltimore, Maryland 21205, United - - 2012
Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) is a potent and selective allosteric inhibitor of kidney-type glutaminase (GLS) that has served as a molecular probe to determine the therapeutic potential of GLS inhibition. In an attempt to identify more potent GLS inhibitors with improved drug-like molecular properties, a series of BPTES analogs were synthesized ...
Marcelino José M - - 2012
OBJECTIVES:: To characterize the nature and dynamics of the neutralizing antibody (NAb) response and escape in chronically HIV-2 infected patients. METHODS:: Twenty-eight chronically infected adults were studied over a period of 1-4 years. The neutralizing activity of plasma immunoglobulin G (IgG) antibodies against autologous and heterologous primary isolates was analyzed ...
Suckow Shelby K SK Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97223, - - 2013
The periaqueductal gray (PAG) is a critical brain region involved in opioid analgesia and provides efferents to descending pathways that modulate nociception. In addition, the PAG contains ascending pathways to regions involved in the regulation of reward, including the substantia nigra (SN) and the ventral tegmental area (VTA). SN and ...
Ross Audrey G AG Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, New York 10027, United - - 2013
Halocycloalkenones are demonstrated to function as potent dienophiles in inter- and intramolecular Diels-Alder cycloadditions. We have found 2-brominated cycloalkenone dienophiles to be both highly endo selective and significantly more reactive than their nonhalogenated parent compounds. A method for the facile conversion of brominated cyclobutanone DA adducts to synthetically useful cyclopropyl ...
Aboye Teshome L TL Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90033, United - - 2012
Herein, we report for the first time the design and synthesis of a novel cyclotide able to efficiently inhibit HIV-1 viral replication by selectively targeting cytokine receptor CXCR4. This was accomplished by grafting a series of topologically modified CVX15 based peptides onto the loop 6 of cyclotide MCoTI-I. The most ...
Czekster Clarissa M CM Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, United - - 2012
Tetrahydrofolate cofactors are required for one carbon transfer reaction involved in the synthesis of purines, amino acids, and thymidine. Inhibition of tetrahydrofolate biosynthesis is a powerful therapeutic strategy in the treatment of several diseases, and the possibility of using antifolates to inhibit enzymes from Mycobacterium tuberculosis has been explored. This ...
Chung Cindy C Materials Science and Engineering, Stanford University, Stanford, California 94305, United - - 2012
Native tissues provide cells with complex, three-dimensional (3D) environments comprised of hydrated networks of extracellular matrix proteins and sugars. By mimicking the dimensionality of native tissue while deconstructing the effects of environmental parameters, protein-based hydrogels serve as attractive, in vitro platforms to investigate cell-matrix interactions. For cell encapsulation, the process ...
Hui Fan F Department of Chemistry and Biochemistry, 9500 Gilman Drive, University of California, San Diego, La Jolla, CA 92093-0375, - - 2012
Crystal (Cry) proteins are globally used in agriculture as proteinaceous insecticides. They have also been recently recognized to have great potential as anthelmintic agents in targeting parasitic roundworms (e.g., hookworms). The most extensively characterized of the anthelmintic Cry proteins is Cry5B. We report here the 2.3 Å resolution structure of ...
Villacorta Junior Humberto - - 2012
BACKGROUND: Cardiac magnetic resonance imaging is considered the gold-standard method for the calculation of cardiac volumes. Transthoracic impedance cardiography assesses the cardiac output. No studies validating this measurement, in comparison to that obtained by magnetic resonance imaging, are available. OBJECTIVE: To evaluate the performance of transthoracic impedance cardiography in the ...
- - 2012
Epilepsy is a neurologic disorder that negatively affects the quality of life for millions of persons in the United States; however, nationally representative U.S. estimates of the prevalence of epilepsy are scant. To determine epilepsy prevalence among adults, assess their access to care, and provide baseline estimates for a Healthy ...
- - 2012
Background: Breast cancer death rates have been declining among U.S. women since 1990 because of early detection and advances in treatment; however, all racial groups have not benefited equally. Methods: Breast cancer incidence, stage at diagnosis, and mortality rates for 2005-2009 for women in the United States and for each ...
- - 2012
Secondhand smoke (SHS) exposure causes heart disease and lung cancer in nonsmoking adults and several health conditions in children. Only completely eliminating smoking in indoor spaces fully protects nonsmokers from SHS. State and local laws can provide this protection in enclosed workplaces and public places by completely eliminating smoking in ...
Kawabata-Yoshihara Liz Andrea - - 2012
BACKGROUND: Atrial fibrillation (AF) is a controversial risk factor for dementia. OBJECTIVE: The objective of this study was to assess the association between AF and dementia in the "Sao Paulo Ageing & Health" (SPAH) study participants. METHODS: SPAH is a cross-sectional, population-based study of elderly people living in a deprived ...
YurtdaƟ Mustafa - - 2012
BACKGROUND: Natriuretic peptides are released by the heart in response to wall stress. OBJECTIVE: The NT-Pro-BNP concentrations in slow coronary flow (SCF) patients were assessed before and after the exercise test and compared with the values of healthy controls. METHODS: The study population was 34 patients with SCF [22 males ...
Yuan Shi-Min - - 2012
Contegra, a bovine jugular vein graft, has been widely used as a preferable biomaterial in the surgical treatment of congenital heart defects, especially as a conduit for the right ventricular outflow tract reconstruction. This article aims to make a comprehensive review on the clinical outcomes of Contegra. Reports of Contegra ...
- - 2012
In 2010, an estimated 18.8 million persons in the United States had diagnosed diabetes mellitus and another 7.0 million had undiagnosed diabetes. Since 1990, the prevalence of diagnosed diabetes in the United States has risen sharply among all age groups, both sexes, and all racial/ethnic groups for which data are ...
Takimura Celso Kiyochi - - 2012
BACKGROUND: Fast post-implantation stent endothelialization is desirable for theoretically reducing the possibility of stent thrombosis. OBJECTIVE: To evaluate the extent of sirolimus-eluting stent strut endothelialization (delivered from the luminal and abluminal aspects or abluminal aspect only) in the iliac arteries of rabbits. METHODS: The iliac arteries of 10 rabbits were ...
Habesoglu Mehmet - - 2012
Our objective was to determine the effect of different types of otologic surgeries on tinnitus symptoms. Our study consisted of 63 patients who were operated between January and June 2011. Variables such as age, sex, presence of systemic diseases, location and size of the perforation, duration of dry period, type ...
Gámez-González Luisa Berenise - - 2012
Recently, there have been increasing reports of severe forms of Kawasaki disease (KD) associated with shock that have been managed in pediatric intensive care units. It has been suggested that KD is more severe in the Hispanic population. We conducted a study to determine the frequency of Kawasaki disease shock ...
Ramírez Iliana María - - 2012
This paper presents a study on a system comprised of a low-dimensional structure (Ga(1-x)Al(x)As and GaAs quantum well wire), an intense laser field and an applied magnetic field in axial direction, resulting in a modified structure by interaction with the laser field. A variation of the concentration of aluminum is ...
Smith Stacy R - - 2012
To the Editor: In their Perspective article, Basu and Hassenplug (Aug. 9 issue)(1) claim that the time required for patients to gain access to high-risk medical devices is roughly similar in the United States and the European Union. However, the authors do not consider in their estimates the development time ...
Chevallier L - - 2012
We have previously described SEG/Pas as the first mouse inbred strain able to survive subcutaneous injection of virulent Yersinia pestis, the agent of plague, and we identified Yprl1, Yprl2 and Yprl3 as three quantitative trait loci (QTLs) controlling this exceptional phenotype in females from a backcross between SEG/Pas and C57BL/6 ...
Raman R Shankar - - 2012
A simple technique of decompressing the duodenum following difficult gastrectomies is described which can be applied across the country to reduce the incidence of this serious complication. The procedure has been used in 120 patients with no instance of duodenal blowout.
Manta Fernanda Saloum Neves - - 2012
The Brazilian population is highly heterogeneous as a result of five centuries of inter-ethnic mating between native Amerindians, European colonizers and Africans arrived during slavery. This study aimed to assess the proportions of inter-ethnic admixture in the Brazilian population of Rio de Janeiro using autosomal Ancestry-Informative Markers (AIMs). The autosomal ...
Hu Xiao X Neural Systems and Dynamics Laboratory, Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. - - 2012
Normal functioning of the brain depends on the homeostasis (∼ steady state) of its various physiological sub-systems, one of which is the intracranial pressure (ICP) dynamic system. The ICP dynamic system of an injured brain is susceptible to various acute changes that should ideally be detected by ICP monitoring even ...
El-Galaly Tarec C - - 2012
A number of single nucleotide polymorphisms (SNP) have been linked to higher risk of venous thromboembolism (VTE). We investigated the VTE risk associated with SNPs in the GP6 (rs1613662), SERPINC1 (rs2227589), F11 (rs2036914 and rs2289252), FGG (rs2066865), and F12 (rs1801020) genes. In F11, the CC genotype for rs2036914 and the ...
Minaee Bagher - - 2012
Prognosis studies are fast developing and very practical types of medical research. Sciatica is one of the common types of low back pain and identifying prognostic factors of the illness can help physicians and patients to choose best method of practice. The prognostic factors of sciatica are presented from the ...
Owen Roger G - - 2012
This report represents a further update of the consensus panel criteria for the assessment of clinical response in patients with Waldenström macroglobulinaemia (WM). These criteria have been updated in light of further data demonstrating an improvement in categorical responses with new drug regimens as well as acknowledgement of the fact ...
- - 2012
To the Editor: Esbjörnsson and colleagues (July 19 issue)(1) conclude that infection with human immunodeficiency virus type 2 (HIV-2) attenuates the course of HIV-1 infection. Their report raises three issues. First, in Guinea-Bissau, up to 30% of persons infected with both HIV-1 and HIV-2 have coinfection with human T-cell lymphotropic ...
Sandler Inga - - 2012
Molecular co-evolution is manifested by compensatory changes in proteins designed to enable adaptation to their natural environment. In recent years, bioinformatics approaches allowed for the detection of co-evolution at the level of the whole protein or of specific residues. Such efforts enabled prediction of protein-protein interactions, functional assignments of proteins ...
Hamadanchi Ali - - 2012
ABSTRACT: BACKGROUND: Infective Endocarditis (IE) is considered as a multifaceted problem in every aspect from etiology and presentation to diagnosis and management. Early recognition of this disease and especially its complications, remain a critical task for the cardiologist. Atrial endocarditis is a rare and sometimes unrecognized complication of mitral valve ...
Niehrs Christof - - 2012
30 years after the identification of WNTs, their signal transduction has become increasingly complex, with the discovery of more than 15 receptors and co-receptors in seven protein families. The recent discovery of three receptor classes for the R-spondin family of WNT agonists further adds to this complexity. What emerges is ...
Conforti P - - 2012
Current therapeutic strategies for Huntington's disease (HD) are focused on symptom management of disease progression. Transcriptional dysregulation is one of the major characteristics in HD. REST is a transcriptional repressor that silences gene expression through binding to RE1/NRSE sites found in the regulatory regions of numerous neuronal genes. Dysregulation of ...
Lim Michelle - - 2012
Endothelial dysfunction is a key pathogenic mechanism of cardiovascular diseases. The retinal microvascular network offers a unique, non-invasive window to study endothelial function. Recently, dynamic measurement of retinal vessel caliber using flicker light stimulation has been used to evaluate potential endothelial dysfunction and other mechanisms in cardiovascular diseases. A variety ...
Miyake Takatomo - - 2012
BACKGROUND: Retinal ischemia in eyes with diabetic retinopathy and retinal vein occlusion leads to local tissue acidosis. Acid-sensing ion channels (ASICs) are expressed in photoreceptors and other neurons in the retina, and may play a role in acid-induced cell injury. The purpose of this study was to investigate the neuroprotective ...
Feng Xin - - 2012
Switchable reaction patterns of beta-substituted cyclic enones have been reported via amine-based dienamine activation. While gama-regioselective vinylogous Michael addition was observed with alkylidenemalononitriles, a completely different [4+2] cycloaddition was obtained with allylidene- or alkynylidenemanolonitrile substrates, affording densely substituted bicyclo[2.2.2]octanes or analogous architectures with moderate to excellent diastereo- and enantioselectivity by ...
Lucarelli Giuseppe - - 2012
PURPOSE: Kidney retransplantation is the best treatment option for transplanted patients returning to dialysis. The aim of this study was to explore the effect of removal of a failed graft on the outcome of a subsequent transplant. METHODS: We identified 140 patients who underwent retransplantation at our institution. Retrospective comparison ...
Kully-Martens Katrina - - 2012
Individuals with fetal alcohol spectrum disorders (FASD) have difficulties with cognitive-based executive function (EF) tasks. The goal of the present study was to determine if children with FASD have impairments on the Iowa Gambling Task (IGT), which measures affective EF (i.e., decision-making and risk-taking). Individuals with FASD (n = 31) ...
Levin A M AM Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, - - 2013
A recent genome-wide association study in a German population and two subsequent studies in European populations found that a non-synonymous single-nucleotide polymorphism (SNP), rs1049550, within the annexin A11 (ANXA11) gene was associated with susceptibility to sarcoidosis. We sought to identify additional ANXA11 variants independently associated with sarcoidosis, determine whether any ...
Campos Ricardo Pereira - - 2012
Previous studies show controversial results regarding the influence of age on health-related quality of life (HRQOL) in patients with Fibromyalgia (FM). While some studies suggest that elderly patients have a worse HRQOL when compared with younger patients, others did not find differences according to age. The aim of the study ...
Burke Derek G - - 2012
Lysosomal glucocerebrosidase (GBA1) deficiency is causative for Gaucher disease. Not all individuals with GBA1 mutations develop neurological involvement raising the possibility that other factors may provide compensatory protection. One factor may be the activity of the non-lysosomal β-glucosidase (GBA2) which exhibits catalytic activity towards glucosylceramide and is reported to be ...
Yin Yeshi Y State Key Laboratory of Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang, - - 2013
Segmented filamentous bacteria (SFB) are indigenous gut commensal bacteria. They are commonly detected in the gastrointestinal tracts of both vertebrates and invertebrates. Despite the significant role they have in the modulation of the development of host immune systems, little information exists regarding the presence of SFB in humans. The aim ...
Toster Jeremiah - - 2012
Diatoms are one of the most successful photosynthetic organisms and given the important role that their shells (frustules) play in light trapping we explored their use in multilayered materials for application as photoanodes in dye sensitised solar cells (DSSCs). We find a substantial improvement in energy conversion efficiency of 30%, ...
- - 2012
To the Editor: Sandborn et al. (Aug. 16 issue)(1) report that tofacitinib has efficacy in the treatment of ulcerative colitis. The authors note that Janus kinase (JAK) inhibitors JAK1 and JAK3 are surprisingly ineffective in the treatment of Crohn's disease.(2) In Crohn's disease, the major cytokines arise from the differentiation ...
Jones Christopher M CM Department of Microbiology, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, - - 2013
Nitrous oxide (N(2)O) is a major radiative forcing and stratospheric ozone-depleting gas emitted from terrestrial and aquatic ecosystems. It can be transformed to nitrogen gas (N(2)) by bacteria and archaea harboring the N(2)O reductase (N(2)OR), which is the only known N(2)O sink in the biosphere. Despite its crucial role in ...
Umar Asad - - 2012
Prevention of cancer remains the most promising strategy for reducing both its incidence and the mortality due to this disease. For more than four decades, findings from epidemiology, basic research and clinical trials have informed the development of lifestyle and medical approaches to cancer prevention. These include selective oestrogen receptor ...
Vafai Scott B - - 2012
Much of our current knowledge about mitochondria has come from studying patients who have respiratory chain disorders. These disorders comprise a large collection of individually rare syndromes, each presenting in a unique and often devastating way. In recent years, there has been great progress in defining their genetic basis, but ...
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