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Results 601 - 650 of 1756
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McGrath Terence F - - 2012
Unregulated growth promoter use in food-producing animals is an issue of concern both from food safety and animal welfare perspectives. However, the monitoring of such practices is analytically challenging due to the concerted actions of users to evade detection. Techniques based on the monitoring of biological responses to exogenous administrations ...
Moos Katharina - - 2012
The right intraparietal sulcus (rIPS) is a key region for the endogenous control of selective visual attention in the human brain. Previous studies suggest that the rIPS is especially involved in top-down control and spatial distribution of attention across both visual hemifields. We further explored these attentional functions using transcranial ...
Cwykiel Joanna M - - 2012
Pulsed acoustic cellular expression (PACE) is a treatment that applies focused acoustic shock waves to promote tissue healing. The aim of this study was to assess the effect of PACE treatment on inflammatory responses in a cremaster muscle ischemia/reperfusion injury model. Seventeen cremaster muscle flaps were evaluated in four groups: ...
Cialdella-Kam Lynn - - 2012
Quercetin, a flavonol in fruits and vegetables, has been demonstrated to have antioxidant, anti-inflammatory and immunomodulating influences. The purpose of the present study was to determine if quercetin, vitamin C and niacin supplements (Q-500 = 500 mg/d of quercetin, 125 mg/d of vitamin C and 5 mg/d of niacin; Q-1000 = 1000 mg/d of quercetin, 250 mg/d of vitamin ...
Borges Alex S - - 2012
Six new lanthanide complexes of stoichiometric formula (C)(2)[Ln(Pic)(5)]-where (C) is a imidazolium cation coming from the ionic liquids 1-butyl-3-methylimidazolium picrate (BMIm-Pic), 1-butyl-3-ethylimidazolium picrate (BEIm-Pic), and 1,3-dibutylimidazolium picrate (BBIm-Pic), and Ln is Eu(III) or Gd(III) ions-have been prepared and characterized. To the best of our knowledge, these are the first cases ...
Wang Jia-Ni - - 2012
A highly selective fluorescent chemosensor for Cr(3+) in aqueous solution was assembled by a low-selectivity fluorogenic receptor with Cu(2+) as a metal quencher. Three tetranitrogen chelating sites were integrated into the multichannel receptor with a tris(1,10-phenanthroline)ruthenium(II) fluorophore at the core. This receptor (2) exhibits chelating affinity for many transition-metal cations, ...
Solomonica Amir - - 2012
BACKGROUND: -Dyspnea relief constitutes a major treatment goal and a key measure of treatment efficacy in decompensated heart failure. However, there is no data with regard to the relationship between hemodynamic measurements during treatment and dyspnea improvement. METHODS AND RESULTS: -We studied 233 patients assigned to right heart catheterization in ...
Wang Jianqing - - 2012
The World Health Organization's (WHO) recommendation on the need for further research for radio-frequency dosimetry has promoted studies on the whole-body average-specific absorption rate (WBA-SAR) in various kinds of anatomical-based numerical models. For experimental validation of GHz-band WBA-SARs in a real human, however, there have not so far been any ...
Yasui Matthew T - - 2012
Visualization of proteins and mass spectrometry (MS) based analyses are elemental tasks in modern biochemistry. Nevertheless, reports about covalent protein dyes and their suitability for subsequent MS experiments remain scarce. In a recent work we demonstrated that covalent pre-staining of proteins with Uniblue A drastically speeds up proteomic work-flows. The ...
Pedrón Valeria T - - 2012
In previous studies we have reported sex-related differences during morphine withdrawal. We have also shown that the GABA(B) agonist baclofen was able to prevent the morphine withdrawal syndrome in male as well as in female mice. Considering that early gene expression is induced by drugs of abuse, we evaluated the ...
Zhang Bingbo - - 2012
Nanoclusters of superparamagnetic iron oxide nanoparticles (SPION) are developed for liver-specific magnetic resonance imaging (MRI) by a unique synthesis route. The process is efficient, environmentally benign, and straight forward within five minutes. The clustering effect is triggered in the presence of bovine serum albumin (BSA) aqueous phase under ultrasonication condition. ...
Lee Sungkyu - - 2012
OBJECTIVE: To analyse the tactics transnational tobacco companies (TTCs) used to increase market share in South Korea after market liberalisation in 1988, and the subsequent impact of TTCs' activities on the domestic industry and ultimately public health. METHODS: Internal tobacco industry documents were searched iteratively and analysed by keyword related ...
Hou Shili - - 2012
The thermal formal [1,3]-sigmatropic shift of allyl aryl ethers has been studied in depth experimentally with the aid of the density functional theory (DFT) calculations of the B3LYP function. Three mechanistic possibilities, referred to as the radical, ionic, and concerted mechanisms, had previously been put forth to explain the thermal ...
Xu Dong - - 2012
microRNAs (miRNAs) are negative regulators of gene expression and can function as tumor suppressors or oncogenes. Several miRNAs are associated with the development of hepatocellular carcinoma (HCC). miR-96 has been closely associated with cell proliferation and clonogenicity. Upregulation of miR-96 has been observed in various types of cancer. However, the ...
Foroughipour Mohsen - - 2012
BACKGROUND: Fatigue is a common symptom in patients with multiple sclerosis (MS). It has significant negative effects on the quality of life of patients with the condition. There are few therapeutic modalities for fatigue, which are also usually not sufficiently effective. The aim of this study was to evaluate the ...
Zeppenfeld Martin - - 2012
Polar molecules have a rich internal structure and long-range dipole-dipole interactions, making them useful for quantum-controlled applications and fundamental investigations. Their potential fully unfolds at ultracold temperatures, where various effects are predicted in many-body physics, quantum information science, ultracold chemistry and physics beyond the standard model. Whereas a wide range ...
Hanafusa Tadashi - - 2012
ABSTRACT: BACKGROUND: Identification of new cancer antigens is necessary for the efficient diagnosis and immunotherapy. A variety of tumor antigens have been identified by several methodologies. Among those antigens, cancer/testis (CT) antigens have became promising targets. METHODS: The serological identification of antigens by the recombinant expression cloning (SEREX) methodology has ...
Gaens Michaela E - - 2012
Purpose:To compare four known pharmacokinetic models for their ability to describe dynamic contrast material-enhanced magnetic resonance (MR) imaging of carotid atherosclerotic plaques, to determine reproducibility, and to validate the results with histologic findings.Materials and Methods:The study was approved by the institutional medical ethics committee. Written informed consent was obtained from ...
Senchenkov Alex - - 2012
Limb salvage procedures in previously operated, radiated, and vessel-depleted fields rely heavily on the use of microvascular tissue transfer. This report illustrates the feasibility of the use of ovarian vessels for the revascularization of a free flap. We have achieved success with the use of rectus abdominis muscle free flap ...
Saltzman Darin J - - 2012
BACKGROUND: Free tissue transplantations are lengthy procedures that result in prolong tissue ischemia. Restoral of blood flow is essential for free flap recovery; however, upon reperfusion tissue that is viable may continue to be nonperfused. To further elucidate this pathophysiology skeletal muscle microcirculation was investigated during reperfusion following 4-hour single ...
Avraham Y - - 2012
Leptin is a potent AMP kinase (AMPK) inhibitor that induces neuroprotection, neurogenesis, and angiogenesis when administered immediately after stroke. To dissociate these effects, we explored the effects of delayed administration of leptin, at 10 days after stroke onset, on neurogenesis and angiogenesis after stroke. Sabra mice underwent photothrombotic stroke and ...
Sulemanji Demet S - - 2012
PURPOSE: Our aim was to compare adaptive support ventilation with and without closed loop control by end tidal CO(2) (ASVCO(2), ASV) with pressure (PC) and volume control ventilation (VC) during simulated clinical scenarios [normal lungs (N), COPD, ARDS, brain injury (BI)]. METHODS: A lung model was used to simulate representative ...
Leonard Steven N - - 2012
OBJECTIVES: Continued selective pressure from glycopeptide use has led to non-susceptible strains of Staphylococcus aureus, including vancomycin-intermediate S. aureus (VISA). Though relatively uncommon, VISA presents a particularly difficult clinical challenge when it arises. Pertinent to this investigation is the correlation between vancomycin intermediacy and daptomycin non-susceptibility. The aim of this ...
Friedrich Felix W - - 2012
AIMS: The transcription factor Islet-1 (ISL1) is a marker of cardiovascular progenitors and is essential for mammalian cardiogenesis. An ISL1 haplotype has recently been associated with congenital heart disease. In this study we evaluated whether ISL1 variants are associated with hypertrophic (HCM), dilated (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), or ...
Maghnie Mohamad - - 2012
OBJECTIVES: Neuroimaging has become an essential part of the diagnostic process in children with growth hormone deficiency (GHD). The aim of the study was to document the frequency of neuro-anatomical abnormalities in a very large cohort of children with GHD and to relate these findings to patient clinical characteristics. DESIGN ...
Stempor Przemyslaw A - - 2012
ABSTRACT: BACKGROUND: MicroRNA (miRNA) directed gene repression is an important mechanism of posttranscriptional regulation. Comprehensive analyses of how microRNA influence biological processes requires paired miRNA-mRNA expression datasets. However, a review of both GEO and ArrayExpress repositories revealed few such datasets, which was in stark contrast to the large number of ...
Atala Anthony - - 2012
Tissue engineering has emerged at the intersection of numerous disciplines to meet a global clinical need for technologies to promote the regeneration of functional living tissues and organs. The complexity of many tissues and organs, coupled with confounding factors that may be associated with the injury or disease underlying the ...
Rao Archana N - - 2012
DNA microarray assay performance is commonly compromised by spot-spot probe and signal variations as well as heterogeneity within printed microspots. Accurate metrics for captured DNA target signal rely upon uniform spot distribution of both probe and target DNA to yield reliable hybridized signal. While often presumed, this is neither easily ...
Laubert T - - 2012
BACKGROUND: In obstructive defecation syndrome (ODS) combinations of morphologic alterations of the pelvic floor and the colorectum are nearly always evident. Laparoscopic resection rectopexy (LRR) aims at restoring physiological function. We present the results of 19 years of experience with this procedure in patients with ODS. METHODS: Between 1993 and 2012, ...
Alies Bruno - - 2012
Alzheimer's disease is characterized by senile plaques in which metallic ions (copper, zinc, and iron) are colocalized with amyloid-β peptides of different sequences in aggregated forms. In addition to the full-length peptides (Aβ1-40/42), N-terminally truncated Aβ3-40/42 forms and their pyroglutamate counterparts, Aβp3-40/42, have been proposed to play key features in ...
Qiu Li - - 2012
Two linear fused heteroacenes bearing a pyrrolo[3,2-b]pyrrole core have been synthesized via a novel reductive ring closure methodology in three steps and in good overall yield. Preliminary OFET results showed that dinaphtho[2,3-b:2',3'-f]pyrrolo[3,2-b]pyrrole (DNPP) is a potential candidate for organic electronics.
Bellin Diana - - 2012
Sequential recognition of invading microbes and rapid induction of plant immune responses comprise at least two recognition systems. Early basal defenses are initiated by pathogen-associated molecular patterns and pattern recognition receptors (PRRs) in the plasma membrane. Pathogens produce effectors to suppress defense, but plants, in turn, can sense such effectors ...
Ng Francesca - - 2012
Purpose:To determine if computed tomographic (CT) texture features of primary colorectal cancer are related to 5-year overall survival rate.Materials and Methods:Institutional review board waiver was obtained for this retrospective analysis. Texture features of the entire primary tumor were assessed with contrast material-enhanced staging CT studies obtained in 57 patients as ...
Zhao Yong - - 2012
We report the design, synthesis and evaluation of a new type of non-precious metal catalysts that is made from network polymers. 2,6-diaminopyridine was selected as a building-block monomer for the formation of a nitrogen-rich network polymer that self-supports spherical backbone structures and contains high-density metal-coordination sites. A cobalt-/iron-coordinating pyrolyzed polymer ...
Bonaduce I - - 2012
The molecular structure of three low-molecular-weight resins used as paint varnishes has been characterized by use of an approach based on three different mass spectrometric techniques. We investigated the ketone resin MS2A, the aldehyde resin Laropal A81, and the hydrocarbon resin Regalrez 1094, now commonly used in restoration. To date, ...
Stephan Daniel - - 2012
The formation of neuronal circuits is a key process of development, laying foundations for behavior. The cellular mechanisms regulating circuit development are not fully understood. Here, we reveal Psidin as an intracellular regulator of Drosophila olfactory system formation. We show that Psidin is required in several classes of olfactory receptor ...
Li Jihui - - 2012
Mono-N-arylation of benzamidines 1 with aryl boronic acids 2 was effectively achieved in the presence of a catalytic amount of Cu(OAc)(2) and NaOPiv under mild aerobic conditions. Combining this step with an intramolecular direct C-H bond functionalization, catalyzed by the same catalytic system but under oxygen at 120 °C, afforded ...
Nikolaou Marinos - - 2012
We report a rare case of spontaneous uterine rupture of an unscarred uterus caused by adenomyosis in the early third trimester. A 33-year-old primigravid woman was referred to our department because of severe acute abdominal pain and signs and symptoms of hemorrhagic shock. Ultrasound exanimation performed at admission revealed a ...
Yang H - - 2012
SUMMARY The serotype distribution and susceptibility to 14 antimicrobial agents of 526 isolates of Shigella spp. from four hospitals in Sun county, Henan province, China during 2001-2008, were analysed to identify associations of serotypes with resistance trends. S. flexneri was the most frequent species (92·4%), the remainder was S. sonnei. ...
Doornebal Chris W - - 2012
Metastatic disease accounts for over 90% of cancer-related deaths, but the development of effective anti-metastatic agents has been hampered by the paucity of clinically relevant preclinical models of human metastatic disease. Here we report the development of a mouse model of spontaneous breast cancer metastasis which recapitulates key events in ...
Siwendu Njedbo A - - 2012
The aim of the study was to evaluate heterotic and combining ability effects for growth in nine chicken genotypes. A 3 × 3 complete diallel mating system involving two indigenous breeds named Venda (V) and Naked Neck (N) and one commercial broiler breed named Ross 308 (R) were used. The nine genetic ...
Meule Adrian - - 2012
Eveningness preference is associated with unhealthy eating behaviors. We measured state and trait food cravings in chronotypes in the morning and in the evening. Less Evening (E)- than Morning (M)-types reported to have had breakfast. Accordingly, hours that had elapsed since the last meal were higher in E- than M-types ...
Nieves J W - - 2012
There is a need to understand the role of nutrition, beyond calcium and vitamin D, in the treatment and prevention of osteoporosis in adults. Results regarding soy compounds on bone density and bone turnover are inconclusive perhaps due to differences in dose and composition or in study population characteristics. The ...
Wang Xiaodong - - 2012
PURPOSE: To determine if the pattern of retained contrast on immediate postprocedure computed tomography (CT) after particle embolization of hepatic tumors predicts modified Response Evaluation Criteria in Solid Tumors (mRECIST) response. MATERIALS AND METHODS: This study was approved by the Institutional Review Board with a waiver of authorization. One hundred ...
Samadian Samad - - 2012
The bacille Calmette-Guérin, a live attenuated form of Mycobacterium bovis, has been used as anti-cancer immunotherapy for superficial bladder cancer since 1976 [1]. It is now the mainstay of therapy for this condition, which is partly attributable to the low complication rate; indeed 95% have no significant side effects [2]. ...
Amala Kompella - - 2012
Imatinib mesylate is the first tyrosine kinase inhibitor developed and approved for the treatment of chronic myeloid leukemia (CML). In the past few years development of resistance towards imatinib mesylate has been reported. To overcome this problem a series of phenyl amino pyrimidine derivatives have been designed, prepared and evaluated ...
Cohen Jonathan - - 2012
The re-emergence of infection due to multidrug-resistant Gram-negative bacteria in critically ill patients presents particular challenges to clinicians, given the lack of a pipeline of new antibiotics active against these resistant strains. Infected patients have a worse outcome than non-infected patients, although the additional contribution of antimicrobial resistance is less ...
Baskar Baburaj - - 2012
A cascade double-annulation strategy employing diverse pairs of zwitterions with 3-formylchromones is presented that provides stereoselective access to complex tetracyclic benzopyrones. Different zwitterions incorporated different rings that include aza-, oxa-, and carbocycles fused to a common benzopyrone scaffold and in the process created three contiguous chiral centers including an all-carbon-quaternary ...
De Livera Alysha M - - 2012
Metabolomics research often requires the use of multiple analytical platforms, batches of samples, and laboratories, any of which can introduce a component of unwanted variation. In addition, every experiment is subject to within platform and other experimental variation, which often includes unwanted biological variation. Such variation must be removed in ...
Henniges Ute - - 2012
Different pulp samples were irradiated by three energy sources: plasma, electron beaming, and gamma radiation. The effect of increased exposure to irradiation was studied by multi-detector gel permeation chromatography with fluorescence labeling of carbonyl groups to quantify changes of the cellulose. While plasma treatment had no effect, for gamma and ...
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