Search Results
Results 551 - 600 of 1755
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Blondiaux Eléonore - - 2012
Objectives: to describe in ultrasonography (US) and magnetic resonance imaging (MRI) the prenatal findings suggestive of periventricular nodular heterotopia (PNH). Methods: this retrospective case series included fetuses referred for MRI and diagnosed with PNH, which were confirmed by post-natal MRI or autopsy. The type of PNH, associated ventriculomegaly and associated ...
King Ann D - - 2012
Purpose:To determine the diagnostic performance of diffusion-weighted (DW) imaging for the prediction of treatment failure in primary head and neck squamous cell carcinoma (HNSCC).Materials and Methods:The study was approved by the local institutional ethics committee and conducted with informed written consent in patients with primary HNSCC treated with radiation therapy ...
Gandini Roberto - - 2012
PURPOSE: to assess the efficacy and safety of the Outback device in patients with a chronic total occlusion of the superficial femoral artery and evaluate its impact on fluoroscopy and procedural times. MATERIALS AND METHODS: From October 2006 to March 2007, 52 patients affected by TASC II-D superficial femoral artery ...
Tian Junfei - - 2012
This paper reports a potential method that can restore the wettability of bioactive paper-based sensors while maintaining their bioactivity. This study is driven by the need to increase the wettability of the antibody-loaded blood typing paper devices in order to increase the blood typing assaying speed using such paper devices. ...
Billing Peter - - 2012
A novel one-step method for mildly converting cyclic ethers into dibromo compounds is reported. Alcohols, oximes, aldehydes, and ketones are known to react under Appel or Corey-Fuchs reaction conditions but, apparently, these have never been applied to oxetanes or larger cyclic ethers. Treatment of 3,3-dimethyloxetane (1) with tetrabromomethane and triphenylphosphine ...
Malzahn Jessica - - 2012
ABSTRACT: BACKGROUND: The gastrointestinal tissue plays an important role in the pathogenesis of HIV/SIV infection and serves as a viral reservoir in infected individuals under antiretroviral therapy (ART). However, the effect of ART administration in the very early stage of infection on HIV/SIV replication and pathogenesis in gastrointestinal tissue has ...
Galeotti N - - 2012
BACKGROUND: Despite the substantial improvement that antimigraine drugs brought to migraineurs, there is the need for a long-acting and better tolerated migraine treatment than actual pharmacotherapy. St. John's wort (SJW), a medicinal plant endowed with a favourable tolerability profile, showed numerous bioactivities. We here investigated the pain-relieving property of SJW ...
Naneix Fabien - - 2012
Adolescence is a crucial developmental period characterized by specific behaviors reflecting the immaturity of decision-making abilities. However, the maturation of precise cognitive processes and their neurobiological correlates at this period remain poorly understood. Here, we investigate whether a differential developmental time course of dopamine (DA) pathways during late adolescence could ...
Robinson Katherine A - - 2012
Thioredoxin interacting protein (Txnip) is a metabolic regulator, which modulates insulin sensitivity and likely plays a role in type 2 diabetes. We studied the regulation of Txnip in 3T3-L1 adipocytes. Cells were incubated under different conditions and Txnip was measured by immunoblotting. We confirmed that high glucose markedly increases Txnip ...
Mayberry J F - - 2012
BACKGROUND: The guideline offers best practice advice on the care of adults, children and young people with Crohn's disease. AIM: To provide clinically effective and cost-effective evidence-based recommendations to guide clinical practice in a clinical guideline commissioned by the National Institute for Health and Clinical Excellence (NICE). METHODS: A systematic ...
Barlera Simona - - 2012
BACKGROUND: -We developed a prognostic model to assess the risk of all-cause mortality in patients with chronic heart failure (HF). METHODS AND RESULTS: -We examined 6975 patients with chronic HF enrolled in the GISSI-HF trial (3.9 years follow-up). Multi-variable Cox regression models were developed to predict mortality (1969 deaths). By ...
Edwards Francine - - 2012
The purpose of this study is to develop a droplet-based microfluidic device capable of monitoring drug precipitation upon a shift from gastric pH (pH 1.5) to intestinal pH (pH 6.5-7.0). The extent of precipitation occurring in droplets over time was measured using a novel on-chip laser scattering technique specifically developed ...
Liao Yunfeng - - 2012
2-Aryl benzothiazole formation from aryl ketones and 2-aminobenzenethiols under metal- and I(2)-free conditions was described. Various 2-aryl benzothiazoles were selectively obtained in good yields using molecular oxygen as oxidant. DMSO played an important role in this transformation. Functional groups such as methyl, methoxy, fluoro, chloro, bromo and nitro groups were ...
Ziegler Elke - - 2012
Kisspeptins are peptides derived from the metastasis suppressor gene KISS1 interacting with GPR54 as their corresponding receptor. The KISS1/GPR54 system is one regulator of cellular motility mechanisms leading to decreased migration and invasion. Its role in cell proliferation processes is not clearly understood. In this study, breast cancer cell lines, ...
Bonny Olivier - - 2012
We developed a mathematical model of Ca(2+) transport along the late distal convoluted tubule (DCT2) and the connecting tubule (CNT) to investigate the mechanisms that regulate Ca(2+) reabsorption in the DCT2-CNT. The model accounts for apical Ca(2+) influx across transient receptor potential vanilloid 5 (TRPV5) channels, and basolateral Ca(2+) efflux ...
Wissgott Christian - - 2012
PURPOSE: Percutaneous mechanical thrombectomy (PMT) is now established as an alternative treatment of acute arterial occlusions in addition to fibrinolysis and surgical thrombectomy. The objective of this retrospective study was the investigation of a rotational atherothrombectomy catheter in terms of safety and efficacy in the treatment of acute and subacute ...
Fritz Daan - - 2012
BACKGROUND: Data on the long-term effect of dexamethasone on survival in bacterial meningitis are lacking. METHODS: A long-term follow-up study of the European Dexamethasone in Adulthood Bacterial Meningitis Study was performed. In this double-blind, randomized clinical trial, 301 patients were randomly assigned to receive adjunctive dexamethasone (n = 157) or ...
Power Brian D - - 2012
ABSTRACT Background: There is ongoing debate about whether a decline in body mass represents a true risk factor for dementia, whether it is a phenotypic marker of incipient dementia, or perhaps a marker of another process that increases dementia risk. This study was designed to determine if changes in body ...
Kitagishi Yasuko - - 2012
Genetic defects in DNA repair and DNA damage response genes often lead to an increase in cancer incidence. The role of defects is also associated with the modulation of hormone signaling pathways. A number of studies have suggested a role for estrogen in the regulation of DNA repair activity. Furthermore, ...
Ubhi Kiren - - 2012
Alzheimer's disease (AD) is characterized by degeneration of neocortex, limbic system, and basal forebrain, accompanied by accumulation of amyloid-β and tangle formation. Cerebrolysin (CBL), a peptide mixture with neurotrophic-like effects, is reported to improve cognition and activities of daily living in patients with AD. Likewise, CBL reduces synaptic and behavioral ...
Udall Margarita - - 2012
OBJECTIVE: To characterize patient populations with favorable costs after the initiation of pregabalin for the treatment of painful diabetic peripheral neuropathy (pDPN) relative to duloxetine, gabapentin, and amitriptyline. METHODS: Patients were identified from MarketScan having ≥ 1 claim for pDPN (ICD-9-CM codes 250.6 or 357.2) within 60 days of first prescription (index) ...
Yan Xin - - 2012
When the size of a semiconductor crystal is reduced to the nanometer scale, the crystal boundary significantly modifies electron distribution, making properties such as bandgap and energy relaxation dynamics size dependent. This phenomenon, known as quantum confinement, has been demonstrated in many semiconductor materials, leading to practical applications in areas ...
Pashuck E Thomas - - 2012
The ability to regenerate damaged tissue is one of the great challenges in biomaterials and medicine. Successful treatments will require advances in areas ranging from basic cell biology to materials synthesis, but there have been major hurdles in translating the biomedical advances, such as scaffolds that direct stem cell differentiation, ...
Barui Ayan Kumar - - 2012
It is well established that angiogenesis is the process of formation of new capillaries from pre-existing blood vessels. It is a complex process, involving both pro- and anti-angiogenic factors, and plays a significant role in physiological and pathophysiological processes such as embryonic development, atherosclerosis, post-ischemic vascularization of the myocardium, tumor ...
Schulz-Schaeffer Walter J - - 2012
The neuropathologic diagnosis of Parkinson disease (PD) is based on the detection of Lewy bodies in the substantia nigra of patients with a Parkinson syndrome, although the connection between Lewy bodies and the neurodegenerative process is still unclear. Furthermore, the presence of Lewy pathology is not an indicator of clinical ...
Oh Jiyoung - - 2012
Suppressors of cytokine signaling (SOCS) are known as negative regulators of cytokine- and growth factor-induced signal transduction. Recently they have emerged as multifunctional proteins with regulatory roles in inflammation, autoimmunity, and cancer. We have recently reported that SOCS1 has antiapoptotic functions against the TNF-α- and the hydrogen peroxide-induced T cell ...
Feng Shaoxin - - 2012
The surface tension lowering abilities of insoluble steroids progesterone and testosterone were examined at the dodecane-water interface in the presence and absence of surfactants sodium dodecyl sulfate, dodecyl trimethyl ammonium bromide and dodecyl maltoside. In the absence of these surfactants the steroids were able to significantly lower the interfacial tension ...
Chen Lihan - - 2012
Many theories of category learning incorporate mechanisms for selective attention, typically implemented as attention weights that change on a trial-by-trial basis. This is because there is relatively little data on within-trial changes in attention. We used eye tracking and mouse tracking as fine-grained measures of attention in three complex visual ...
Krautkrämer Ellen - - 2012
The function of the kidney with its highly differentiated and specialized cell types is affected by infection with several viruses. Viral infections of the kidney have a negative impact not only on patients undergoing renal transplantation and immunosuppression. Besides the increasing number of patients suffering from HIV-associated nephropathy, another group ...
Pawar Gajanan Manohar - - 2012
We describe the preparation of an injectable, biocompatible and elastic multi-block copolymer hydrogel for biomedical applications, with segmented hydrophobic bisurea hard blocks and hydrophilic PEG blocks. The segmented block copolymers were obtained by the step growth polymerization of amino terminated PEG and aliphatic diisocyanate. Due to their capacity for multiple ...
Connell Barry J - - 2012
After ischemic stroke, early thrombolytic therapy to reestablish tissue perfusion improves outcome but triggers a cascade of deleterious cellular and molecular events. Using a collaborative approach, our groups examined the effects of guanosine (Guo) in response to ischemic reperfusion injury in vitro and in vivo. In a transient middle cerebral ...
Yao Li - - 2012
Abstract The IK6 isoform plays an important role in Ph+ALL. This study was designed to monitor the expression of the IK6 isoform with associated cytogenetic and molecular abnormalities. The IK6 isoform, cytogenetic and molecular abnormalities were detected in 100 de novo Chinese patients with Ph+ adult ALL. The expression levels ...
Niu Yuguang - - 2012
Noise exposure is one of the most common causes of hearing loss. Recent studies found that noise exposure-induced cochlear damage may change the excitability and tonotopic organization of the central auditory system (CAS). This plasticity was suspected to be related to tinnitus and hyperacusis. However, how cochlear damage affects CAS ...
He Yan - - 2012
To investigate the effect of a year of HAART on immune reconstruction and cytokine production in HIV/AIDS patients, 35 AIDS patients were recruited for HAART treatment and 35 healthy volunteers were assigned as controls. The dynamic changes in HIV load, blood T cell subset counts as well as IL-12, IFN-γ, ...
Zheng Jiamin - - 2012
Saliva is a readily available biofluid that may contain metabolites of interest for diagnosis and prognosis of diseases. In this work, a differential (13)C-/(12)C-isotope dansylation labeling method, combined with liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICR-MS), is described for quantitative profiling of the human salivary metabolome. New ...
Yamaguchi Sayuri - - 2012
A proposed structure of roxbin B was synthesized. For the synthesis, a new synthetic method for the preparation of the hexahydroxydiphenoyl (HHDP) bridge was developed that involved the stepwise esterification of axially chiral HHDP acid anhydride. The synthesized compound was not identical to the natural roxbin B.
Haqqani Arsalan S - - 2012
FC5 and FC44 are single-domain antibodies (V¬HHs), selected for their ability to internalize human brain endothelial cells (BEC) and to transmigrate the in vitro BBB model by functional panning of phage-display llama VHH library. Quantification of brain delivery of FC5 and FC44 in vivo was challenging using classical methods because ...
King Graham - - 2012
For many disordered materials, knowing their average crystal structure is insufficient for explaining and predicting their macroscopic properties. It has been found that a description of the short-range atomic arrangements is needed to understand such materials. In order to understand the conduction pathways in ionic conductors which have random distributions ...
N Mallikarjunan - - 2012
Soybean Trypsin Inhibitor (STI) is a known antinutrient and food allergen present in soybean. Gamma radiation has the potential to inactivate the TI protein. However, a systematic study on influence of different moisture levels during gamma radiation on structure and function of the molecule has not been reported. Pure STI ...
Albertshofer Klaus - - 2012
The assembly of complex spirocyclopentaneoxindoles via a novel organocatalytic iminium-enamine cascade process is reported. Reactions between 3-substituted oxindoles and α,β-unsaturated aldehydes catalyzed by second generation prolinol ethers provided the desired products in high yield with excellent levels of enantioselectivity in a single step.
Padmalatha Kethi Reddy - - 2012
ABSTRACT: BACKGROUND: Fuzzless-lintless cotton mutants are considered to be the ideal material to understand the molecular mechanisms involved in fibre cell development. Although there are few reports on transcriptome and proteome analyses in cotton at fibre initiation and elongation stages, there is no comprehensive comparative transcriptome analysis of fibre-bearing and ...
An Jihwan - - 2012
Enhancing the density of catalytic sites is crucial for improving the performance of energy conversion devices. This work demonstrates the kinetic role of 2nm thin YSZ/Pt cermet layers on enhancing the oxygen reduction kinetics for low temperature solid oxide fuel cells. Cermet layers were deposited between the porous Pt cathode ...
Brask-Lindemann D - - 2012
Chronic obstructive pulmonary disease (COPD) and systemic glucocorticoid exposure are well-known risk factors of osteoporosis. We evaluated alendronate prescription practices related to COPD and exposure to systemic corticosteroids from 1996 to 2008 and showed an increasing targeting of alendronate treatment in patients with COPD and patients with systemic corticosteroid exposure. ...
Khan Aysha Habib - - 2012
Of the 305 premenopausal females in a cross-sectional study in randomly selected communities of Karachi, Pakistan, 90.1 % showed to be vitamin D deficient. Age, town of residence, and housing structure were significant predictors of vitamin D levels. Measures to address D deficiency and its associated long latency effects are urgently ...
Pitcher Julia B - - 2012
Preterm-born children commonly experience motor, cognitive, and learning difficulties that may be accompanied by altered brain microstructure, connectivity, and neurochemistry. However, the mechanisms linking the altered neurophysiology with the behavioral outcomes are unknown. Here we provide the first physiological evidence that human adolescents born preterm at or before 37 weeks ...
Pereira Rui - - 2012
OBJECTIVES: Antimicrobial resistance in Neisseria gonorrhoeae is an increasing problem worldwide and combinations of antimicrobial agents have been recommended to delay the onset of treatment failures. The objective of this study was to obtain in vitro data on the activity of current (ceftriaxone or cefixime plus azithromycin) and alternative (gentamicin ...
Lye J E - - 2012
The ARPANSA calibration service for (60)Co gamma rays is based on a primary standard graphite calorimeter that measures absorbed dose to graphite. Measurements with the calorimeter are converted to the absorbed dose to water using the calculation of the ratio of the absorbed dose in the calorimeter to the absorbed ...
Metallo Christian M - - 2012
Metabolism is again emerging as a key property that differentiates normal cells from neoplastic tissues. The coupling of this phenomenon with advanced bioanalytic methods may now open new avenues for diagnostics in cancer via discovery of chemical biomarkers. In this issue of Cancer Prevention Research, Montrose and colleagues apply metabolic ...
Lucas Matthew Charles - - 2012
A novel approach to design selective spleen tyrosine kinase (Syk) inhibitors is described. Inhibition of spleen tyrosine kinase has attracted much attention as a mechanism for the treatment of autoimmune diseases such as asthma, rheumatoid arthritis, and SLE. Fostamatinib, a Syk inhibitor that successfully completed Phase II clinical trials, also ...
McGrath Terence F - - 2012
Unregulated growth promoter use in food-producing animals is an issue of concern both from food safety and animal welfare perspectives. However, the monitoring of such practices is analytically challenging due to the concerted actions of users to evade detection. Techniques based on the monitoring of biological responses to exogenous administrations ...
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