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Results 501 - 550 of 1756
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Kluft C - - 2012
INTRODUCTION: There is no clear consensus about tests in vitro that are suitable for evaluating various factor Xa inhibitors. The availability of reversible and irreversible inhibitors further complicates the application of available assays. METHODS: We evaluated the suitability of the prothrombinase-induced clotting test (PiCT) for fondaparinux and rivaroxaban, as representatives ...
Ranjani Harish - - 2012
Abstract Aim: This study was designed to determine the prevalence of glucose intolerance (prediabetes or diabetes) in children and adolescents in urban South India. Subjects and Methods: Children (6-11 years old) and adolescents (12-19 years old) (n=1,519; 777 boys and 742 girls) were randomly selected from residential apartments representing the ...
Lappegård Trude - - 2012
This article analyzes male fertility, with a particular focus on multipartner fertility, for cohorts born 1955 to 1984 in Norway. We find that socioeconomically disadvantaged men have the lowest chance of becoming fathers and the lowest likelihood of fathering multiple children in stable unions. Multipartner fertility, on the other hand, ...
Robbins Kevin J - - 2012
The interaction of small molecules with the surface of amyloid assemblies is important for the detection and inhibition of amyloid formation. Thioflavin T (ThT), a small molecular rotor, has been used for the detection of amyloid fibrils for over half a century. The basis for detection is simple in that ...
Grant K M - - 2012
Current global warming necessitates a detailed understanding of the relationships between climate and global ice volume. Highly resolved and continuous sea-level records are essential for quantifying ice-volume changes. However, an unbiased study of the timing of past ice-volume changes, relative to polar climate change, has so far been impossible because ...
Techritz Sandra - - 2012
OBJECTIVE: Mitochondria fulfill many tissue-specific functions in cell metabolism. We set out to identify differences in the protein composition of mitochondria from five tissues frequently affected by mitochondrial disorders. METHODS: The proteome of highly purified mitochondria from five mouse organs was separated by high-resolution 2D-electrophoresis (2DE). Tissue-specific spots were identified ...
Regge Daniele - - 2013
To assess the effect of computer-aided detection (CAD) as a second reader on the sensitivity and specificity of computed tomographic (CT) colonography in detecting 6-9-mm colorectal cancer (CRC) lesions. Individuals with clinical indications for colonoscopy--either for symptoms or as part of participating in a surveillance program or CRC screening--were prospectively ...
Dong Heng - - 2012
Microbial fuel cells (MFCs) being an environment-friendly technology for wastewater treatment is limited by its low efficiency and high cost. Power output based on capital cost had been greatly increased in our previous work by introducing a novel activated carbon (AC) air-cathode (ACAC). The catalysis behavior of this ACAC was ...
Allen Jane A - - 2012
OBJECTIVE: To describe differences in and factors associated with former smoking and nicotine dependence among women in Ireland, Sweden, France, Italy and the Czech Republic. METHODS: A cross-sectional, random digit dial telephone survey of 5000 women, aged 18 years and older, conducted in 2008. Analyses were conducted using logistic regression ...
Kumar Saroj - - 2012
Drug development is impeded by the need to design for each drug target a test that detects the binding of drug candidate molecules to the target protein. Therefore a general method to detect ligand binding is highly desirable. Here we present an observation towards developing such a method which is ...
Gammon Cheryl S - - 2012
The unique composition of green kiwifruit has the potential to benefit CVD risk. The aim of the present study was to investigate the effect of consuming two green kiwifruits daily in conjunction with a healthy diet on plasma lipids and other metabolic markers and to examine response according to APOE ...
Zhang Aihua - - 2012
Scoparone is an important constituent of Yinchenhao (Artemisia annua L.), a famous medicinal plant, and displayed bright prospects in the prevention and therapy of liver injury. However, the precise molecular mechanism of hepatoprotective effects has not been comprehensively explored. Here, metabolomics techniques are the comprehensive assessment of endogenous metabolites in ...
Saito Yasuhiro - - 2012
Fear extinction-based exposure treatment is an important component of psychotherapy for anxiety disorders such as posttraumatic stress disorder (PTSD). Recent studies have focused on pharmacological approaches combined with exposure therapy to augment extinction. In the present study, we elucidated the therapeutic potential of the serotonin 1A (5-HT(1A) ) receptor agonist ...
Ignaczak Anna - - 2012
In this article, an effect of solvent on potential energy surfaces, constructed at the PBE1PBE/aug-cc-pVTZ level vs C-X distances for the neutral molecules CF(3)X (X = Cl, Br, I) and the corresponding radical anions CF(3)X¯, is studied using the polarizable continuum model (PCM). The properties and energy changes in these ...
Amlien Inge K - - 2012
Purpose:To evaluate the relationship between (a) pathologic levels of cerebrospinal fluid (CSF) total tau as an index of the intensity of ongoing neuronal degeneration and (b) longitudinal changes in white matter (WM) integrity in patients with mild cognitive impairment (MCI).Materials and Methods:Participants gave written informed consent, and the Norwegian committee ...
Wang Fei - - 2012
The chemical bonding schemes of thallium cluster anions commonly comply with neither Wade-Mingos' rules nor the Zintl-Klemm concept and thus far have escaped a fully consistent description. In general, the numbers of electrons available for the cluster skeleton bonding fall below those required according to the qualitative concepts mentioned and ...
Ciavardelli Domenico - - 2012
Metal dyshomeostasis plays a crucial role in promoting several neurodegenerative diseases including Alzheimer's disease (AD), a condition that has been linked to deregulation of brain levels of Al, Fe, Mn, Cu, and Zn. Thus, quantitative multi-element profiling of brain tissues from AD models can be of great value in assessing ...
Prestwich Glenn D - - 2012
Leaders in the field comment on what they perceive to be the greatest barriers to biomaterial translation.
Mirfakhraee Sasan - - 2012
This cross-sectional study was performed to characterize the factors affecting bone mass in male hemodialysis subjects. We found that of all the factors analyzed, the strongest correlation was with body mass index. In fact, after adjusting for body weight, the correlations with bone turnover markers and sex hormones were no ...
Dietz H P - - 2012
INTRODUCTION AND HYPOTHESIS: Avulsion of the puborectalis muscle from its bony insertion is common in women presenting with prolapse. We present a simple vaginal technique for levator reconstruction. METHODS: This is a prospective surgical pilot study comprising 17 patients enrolled to undergo levator repair in the context of prolapse surgery. ...
Driver Todd H - - 2012
With the decrease in transmission via transfusions and injection drug use, acute symptomatic hepatitis C is infrequently seen in developed countries. We report a case of a human immunodeficiency virus (HIV)-infected adult who presented with abdominal pain. His alanine aminotransferase was greater than sixty times the upper limit of normal ...
Aquino Antonio E AE - - 2012
Obesity and associated dyslipidemia is the fastest growing health problem throughout the world. The combination of exercise and low-level laser therapy (LLLT) could be a new approach to the treatment of obesity and associated disease. In this work, the effects of LLLT associated with exercises on the lipid metabolism in ...
Toback Seth L - - 2012
Influenza B is responsible for significant morbidity in children and adults worldwide. For more than 25 years, two antigenically distinct lineages of influenza B viruses, B/Yamagata and B/Victoria, have cocirculated globally. Current influenza vaccine formulations are trivalent and contain two influenza subtype A strains (A/H1N1 and A/H3N2) but only one ...
Zhang Hong-Liang - - 2012
OBJECTIVE: Cerebral autoregulation (CA) is the mechanism by which constant cerebral blood flow is maintained despite changes in cerebral perfusion pressure. CA can be evaluated by dynamic monitoring of cerebral blood flow velocity (CBFV) with transcranial Doppler sonography (TCD). The present study aimed to explore CA in chronic anxiety. METHODS: ...
Skilton Michael R - - 2012
BACKGROUND: Impaired fetal growth is independently associated with an increased risk of cardiovascular events in adulthood. Prevention strategies that can be implemented during adulthood have not been identified. OBJECTIVE: The objective was to determine whether habitual omega-3 (n-3) fatty acid intake is associated with the rate of increase of carotid ...
Tustison Nicholas J - - 2012
Recent discussions within the neuroimaging community have highlighted the problematic presence of selection bias in experimental design. Although initially centering on the selection of voxels during the course of fMRI studies, we demonstrate how this bias can potentially corrupt voxel-based analyses. For such studies, template-based registration plays a critical role ...
San Jose Benedict Arcena - - 2012
We synthesized di-substituted liquid crystalline polyacetylene (di-LCPA) derivatives bearing 4-nonyloxy phenyl groups with lyotropic and thermotropic LC behavior. The poly(diphenylacetylene) (PDPA) main chain structure of the di-LCPAs and the chirality induced with either chiral moieties or chiral dopants allow the formation of a highly ordered lyotropic N*-LC phase. Circular dichroism ...
Lupi Alessandro - - 2012
Background: Biodegradable polymer drug eluting stents (BP-DES) have been developed to overcome the limitations of first generation durable polymer DES (DP-DES) but the clinical results of different BP-DES are not consistent. We performed a meta-analysis to compare the outcomes of BP-DES and DP-DES in the treatment of coronary artery disease ...
Dear Blake F - - 2012
Background:Depression is an important health issue amongst older adults. Internet-delivered cognitive behaviour therapy (iCBT) may help to reduce barriers and improve access to treatment, but few studies have examined its use with older adults. The present study evaluated the efficacy, acceptability and feasibility of a brief iCBT program, the Managing ...
Lo Vasco Vincenza Rita - - 2012
The development of the nervous system is under the strict control of a number of signal transduction pathways, often interconnected. Among them, the phosphoinositide (PI) pathway and the related phospholipase C (PI-PLC) family of enzymes have been attracting much attention. Besides their well-known role in the regulation of intracellular calcium ...
Shen Zhanlong - - 2012
Kindlin-2 is a novel focal adhesion gene mediating the cell-extracellular matrix (ECM) adhesion. Tumor-associated macrophages (TAMs) play an important role in linking chronic inflammation to cancer progression. Both kindlin-2 and TAMs have been found to promote the invasion of gastric cancer cells in our previous studies. However, the correlation between ...
Martínez-González Alicia - - 2012
Glioblastoma is a rapidly evolving high-grade astrocytoma that is distinguished pathologically from lower grade gliomas by the presence of necrosis and microvascular hyperplasia. Necrotic areas are typically surrounded by hypercellular regions known as "pseudopalisades" originated by local tumor vessel occlusions that induce collective cellular migration events. This leads to the ...
Wijtmans Maikel - - 2012
The G protein-coupled chemokine receptor CXCR3 plays a role in numerous inflammatory events. The endogenous ligands for the chemokine receptors are peptides, but in this study we disclose small-molecule ligands that are able to activate CXCR3. A class of biaryl-type compounds that is assembled by convenient synthetic routes is described ...
Białońska Agata - - 2012
[Fe(ebtz)(2)(C(2)H(5)CN)(2)](ClO(4))(2) was prepared in the reaction of 1,2-di(tetrazol-2-yl)ethane (ebtz) with Fe(ClO(4))(2)·6H(2)O in propionitrile. The compound crystallizes as a one-dimensional (1D) network, where bridging of neighboring iron(II) ions by two ebtz ligand molecules results in formation of a [Fe(ebtz)(2)](∞) polymeric skeleton. The 1D chains are assembled into supramolecular layers with axially ...
Macpherson Hugh - - 2012
ABSTRACT: BACKGROUND: The evidence on the effect of acupuncture or counseling for depression is not conclusive yet is sufficient to warrant further research. Our aim is to conduct a full-scale RCT to determine the clinical and cost effectiveness of acupuncture and counseling compared to usual care alone. We will explore ...
Trouillon Raphael - - 2012
An overview of methods developed for chemical analysis of single cells over the last two years is presented. Many biological systems contain an ensemble of cells with heterogeneous chemistry; therefore it is important to analyze them on an individual basis in order to elucidate the role each cell plays in ...
Pennick M O - - 2012
Although first described almost half a century ago, parastomal varices are not easily recognised as a cause of stomal bleeding even though they occur in up to 5 % of all people who have a stoma. The main challenges associated with this condition are diagnosis and management. For that reason, the ...
Jopling Chris - - 2012
BACKGROUND: Hypoxia plays an important role in many biological/pathological processes. In particular, hypoxia is associated with cardiac ischemia which, while initially inducing a protective response, will ultimately lead to the death of cardiomyocytes and loss of tissue, severely impacting cardiac functionality. While myocardial damage/loss remains an insurmountable problem for adult ...
Chang Cherylee W J - - 2012
OBJECTIVE: We report the clinical characteristics of the largest series of nontraumatic spinal cord injury in novice surfers (surfers' myelopathy). METHODS: A retrospective review of the electronic medical record was performed in patients with nontraumatic spinal cord injury associated with surfing identified upon admission to the largest tertiary referral hospital ...
Schlecker Eva - - 2012
Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of myeloid cells in cancer patients and tumor-bearing mice that potently inhibits T cell responses. During tumor progression, MDSCs accumulate in several organs, including the tumor tissue. So far, tumor-infiltrating MDSC subpopulations remain poorly explored. In this study, we performed global gene ...
Yang Bo - - 2012
An oligodeoxynucleotide (ODN) containing a 2',2'-difluorinated analogue of a C4'-oxidized abasic site (C4'-OAS) was designed for the amine modification of biomolecules that interact with nucleic acids. In contrast to the parent C4'-OAS, which yielded amine-modified products accompanied by DNA strand scission, the ODN containing the difluoro C4'-OAS efficiently yielded products ...
Sun Yao-Gui - - 2012
The immune adherence (IA) between the porcine erythrocytes and the opsonized Escherichia coli carried green fluorescent protein gene (GFP-E.coli) were detected by the fluorescence microscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) with an attempt to verify the existence of IA between the porcine erythrocytes and complemented-opsonized microbes. ...
Frank Claudia - - 2012
Two reference measurement procedures are presented here that allow the determination of the iron saturation in human transferrin, based on different molecular properties. The results, directly derived from the number of ions bound to the protein molecule, are traceable to the SI. Up to now, the iron saturation has only ...
Goldberg Ronald B - - 2012
Background:A randomised, double-blind, placebo-controlled study evaluated lipid- and glucose-lowering effects of colesevelam in patients with prediabetes and primary hyperlipidaemia. We report the effect of colesevelam on lipoprotein particle concentration and particle size (determined by nuclear magnetic resonance spectroscopy) in these patients.Methods:Adults with prediabetes (World Health Organization criteria), low-density lipoprotein cholesterol ...
Kang J-H - - 2012
This population-based matched cohort analysis explored the effects of bisphosphonate treatment on acute myocardial infarction (AMI). We found that patients who received bisphosphonate therapy had a lower risk of AMI during a 2-year follow-up period (hazard ratio (HR) = 0.35). Our data support that bisphosphonates may provide protective effects against cardiovascular events. ...
Deplaine H - - 2012
Polymer-ceramic composites obtained as the result of a mineralization process hold great promise for the future of tissue engineering. Simulated body fluids (SBFs) are widely used for the mineralization of polymer scaffolds. In this work an exhaustive study with the aim of optimizing the mineralization process on a poly(L-lactic acid) ...
Martin Jason - - 2012
PURPOSE: To perform a literature review of the spectrum of complications associated with UAE relative to surgery and compare the risk of reintervention as well as minor, major, and overall complications. MATERIALS AND METHODS: Literature review was conducted in PubMed, MEDLINE, Cochrane, and CINAHL databases, and meta-analysis was performed. RESULTS: ...
Meye Frank J - - 2012
μ-Opioid receptors (MORs) in the ventral tegmental area (VTA) are pivotally involved in addictive behavior. While MORs are typically activated by opioids, they can also become constitutively active in the absence of any agonist. In the current study, we present evidence that MOR constitutive activity is highly relevant in the ...
Llurba E - - 2012
Objective: To investigate the relation between fetal heart defects and maternal serum placental growth factor (PlGF), a marker of placental angiogenesis, because animal models demonstrated an association between angiogenesis and abnormal heart development. Methods: Maternal serum PLGF, pregnancy associated plasma protein-A (PAPP-A) and uterine artery pulsatility index (PI) at 11-13 ...
Komissarova Maria - - 2012
Acute pulmonary thromboembolism (PE) is a cardiovascular emergency associated with significant morbidity and a 5-35 % mortality for untreated pulmonary embolism. If promptly diagnosed and treated, the mortality rate can be significantly reduced. Diagnosis of acute PE continues to be a clinical challenge, with diagnostic imaging playing an important role. This ...
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