Search Results
Results 451 - 500 of 1755
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Lei Jin - - 2012
Traumatic brain injury (TBI) is a major health and socioeconomic problem worldwide for the high rate of death and long-term disability. Prior studies have summarized evidence from large scale randomized trials, finding no intervention shown convincing efficacy for acute TBI management. The present empirical study set out to assess another ...
Mohan Viswanathan - - 2012
Abstract Objective: This study evaluated the noninvasive, point-of-care diabetes screening device, Scout DS(®) (VeraLight Inc., Albuquerque, NM) (SCOUT), in a native Asian Indian cohort. Research Design and Methods: SCOUT is a tabletop, skin fluorescence spectrometer that reports a risk score following a 3-4-min noninvasive measurement of a subject's left volar ...
Ling Shukuan - - 2012
BACKGROUND: Sustained cardiac pressure overload-induced hypertrophy and pathological remodeling frequently leads to heart failure. Casein kinase-2 interacting protein-1 (CKIP-1) has been identified to be an important regulator of cell proliferation, differentiation and apoptosis. However, the physiological role of CKIP-1 in the heart is unknown. METHODS AND RESULTS: The results of ...
Dunning Thom H TH - - 2012
The dramatic differences between the properties of molecules formed from the late p-block elements of the first row of the periodic table (N-F) and those of the corresponding elements in subsequent rows is well recognized as the first row anomaly. Certain properties of the atoms, such as the relative energies ...
Xu Meihui - - 2012
Dengue virus immune protection is specific to the serotype encountered and is thought to persist throughout one's lifetime. Many serotype cross-reactive memory B cells isolated from humans with previous dengue infection are specific for the nonstructural and the prM structural viral proteins, and they can enhance infection in vitro. However, ...
Murea Mariana - - 2012
ABSTRACT: BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) plays important roles in kidney disease susceptibility and atherogenesis in experimental models. Relationships between serum MCP- 1 concentration and early nephropathy and subclinical cardiovascular disease (CVD) were assessed in African Americans (AAs) with type 2 diabetes (T2D). METHODS: Serum MCP-1 concentration, urine albumin:creatinine ratio ...
Okamoto Toru - - 2012
An attractive approach for developing therapeutic peptides is to enhance binding to their targets by stabilizing their helical conformation, for example stabilized BimBH3 peptides (BimSAHB) designed to induce apoptosis. Unexpectedly, we found that such modified peptides have reduced affinity for their targets, the pro-survival Bcl-2 proteins. We attribute this loss ...
Hrabakova Rita - - 2012
Drug resistance is the major obstacle to successful cancer therapy. Our study focuses on resistance to Aurora kinase inhibitors tested as anti-cancer drugs in clinical trials. We have used 2-D electrophoresis in pH range of 4-7 and 6-11 followed by protein identification using MALDI-TOF/TOF to compare protein composition of HCT116 ...
Khetani Salman R - - 2012
Since drug induced liver injury (DILI) remains a major reason for late stage drug attrition, predictive assays are needed that can be deployed throughout the drug discovery process Clinical DILI can be predicted with a sensitivity of ~50% and a false positive rate of ~5% using 24 hour cultures of ...
Ishikawa Kazuya - - 2012
Fig mosaic virus (FMV), a member of the newly formed genus Emaravirus, is a segmented negative-strand RNA virus. Each of the six genomic FMV segments contains a single open reading frame: that of RNA4 encodes the protein p4. FMV-p4 has been suggested to be the movement protein (MP) of the ...
Schwack Bradley F - - 2012
BACKGROUND: Laparoscopic adjustable gastric banding (LAGB) is safe and effective. This less invasive option involving fewer incisions and umbilical approaches is coined as single-incision laparoscopic surgery (SILS). Over the last 3 years, we performed 46 % of our LAGBs as SILS with excellent results. METHODS: This is a retrospective review of 1,644 ...
Hohm Tim - - 2012
Phototropism allows plants to align their photosynthetic tissues with incoming light. The direction of incident light is sensed by the phototropin family of blue light photoreceptors (phot1 and phot2 in Arabidopsis), which are light-activated protein kinases. The kinase activity of phototropins and phosphorylation of residues in the activation loop of ...
Jakob Mark - - 2012
BACKGROUND: Mesenchymal stem cells (MSCs) are multipotent mesenchymal progenitor cells, originally identified in bone-marrow. Little is known about MSCs of the head and neck region. We investigated cell biological properties with a potential impact on wound healing of 2 different tissue-resident MSC populations. METHODS: MSCs were isolated from human nasal ...
Brownlee Ewan M - - 2012
Abstract Background: Improved cosmesis is widely recognized as the main benefit of single-port laparoscopy (SPL). Recently, some centers have started to perform SPL in infants and neonates. However, in our experience, the cosmetic result following traditional laparoscopic surgery in this age range is excellent. This study assessed infants' postoperative scars ...
Snow Samuel D - - 2012
The vast range of C60 derivatives makes it difficult to assess potential environmental impact of this class of materials, while past environmental studies mostly focused only on pristine C60. Central to derivatized C60's potential to negatively impact (micro)biological receptors upon unintended release is its unique property of mediating the transfer ...
Gonen Korcan Aysun - - 2012
BACKGROUND: Rickets is a complication of infantile osteopetrosis and pre-treatment recognition of this complication is important. OBJECTIVE: To describe four children with infantile osteopetrosis complicated by rickets (osteopetrorickets) and review the relevant literature. MATERIALS AND METHODS: Retrospective chart analysis of four infants with osteopetrorickets and a systematic review of the ...
Béjot Yannick - - 2012
OBJECTIVES: To investigate the premorbid use of secondary prevention medications in patients with recurrent vascular events. DESIGN: Prospective, observational, population based study. SETTING: The Dijon Stroke Registry and the registry of myocardial infarction of Dijon and Côte d'Or, France. PATIENTS: All patients with cerebral ischaemia (ischaemic stroke or transient ischaemic ...
Ofri Danielle - - 2012
When a snarling Hurricane Sandy knocked the lights out at Bellevue Hospital Center on that Monday night, the staff murmured a collective chant: "One-Mississippi, two-Mississippi, three-Mississippi . . . ." We'd been told that if the electricity came back on before we hit "ten-Mississippi," then the backup generators were working fine. A ...
Bolouri Carmen - - 2012
PURPOSE: The aim of this study was to evaluate the performance of a novel flat-panel single photon emission computed tomography (SPECT)/CT in patients with suspicion of osteomyelitis (OM) of the jaw in comparison with conventional orthopantomography (OPT), planar bone scintigraphy (PS) and CT alone. METHODS: Forty-two patients (21 female, 21 ...
Rather Jahangir Ahmad - - 2012
An electrochemical matairesinol biosensor was fabricated by immobilizing tyrosinase on a poly(thionine)/nafion/multi-walled carbon nanotube composite film. A polymeric film of the redox dye thionine enables the stable immobilization of tyrosinase while acting as a mediator for the enzymatic process has been incorporated into the carbon nanotube/nafion composite film. The immobilization ...
Park Joon Pyo - - 2012
ObjectiveWe aimed to determine whether abnormalities in outer hair cell (OHC) function were related to tinnitus through interaural comparison of distortion product otoacoustic emissions (DPOAEs).Study DesignCross-sectional study.SettingTertiary care university teaching hospital.ParticipantsTwenty-seven patients with unilateral tinnitus and pure-tone average of both ears ≤25 dB hearing loss (HL) at 500, 1000, 2000, ...
Jeong Min-Ho - - 2012
The control of melanogenesis is an important strategy in the treatment of abnormal skin pigmentation for cosmetic purposes. The aim of the present study was to investigate the anti-melanogenic effect of Asterina pectinifera (A. pectinifera) extracts by cell-free mushroom tyrosinase assay, cellular tyrosinase assay, melanin content assay and the analysis of related ...
van Leeuwen-Segarceanu Elena M - - 2012
ABSTRACT Radiotherapy has been associated with an increased risk for cardiovascular disease (CVD) in Hodgkin lymphoma survivors (HLS). Identifying subjects most likely to develop these complications is challenging. Arterial stiffness has been frequently used as an early marker of CVD, but was never investigated in patients treated with radiotherapy.
Narayanaswamy Venugopala K - - 2012
A series of 2-(substituted phenyl/benzyl-amino)-6-(4-chlorophenyl)-5-(methoxycarbonyl)-4-methyl-3,6-dihydropyrimidin-1-ium chlorides 7-13 and 15 was synthesized in their hydrochloride salt form. The title compounds were characterized by FT-IR, NMR ((1) H and (13) C) and elemental analysis. They were evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv, multidrug resistance tuberculosis and extensively ...
Alijotas-Reig J - - 2012
Objective: To date, there are no reliable data regarding the actual treatment received by women with refractory obstetric antiphospholipid syndrome (OAPS). The aim of this study was to assess current clinical evidence and new trends in the treatment of refractory OAPS.Methods: A non-systematic but comprehensive literature search using relevant keywords ...
Borrell Antoni - - 2012
Objective: The aim of this study was to assess the best method of combining the fetal nuchal translucency (NT) and ductus venosus (DV) blood flow in the detection of cardiac defects in chromosomally normal fetuses, during the first trimester scan. Study Design: During an 8-year period NT and the DV ...
Haggarty Paul - - 2012
BACKGROUND: Epigenetic regulation of imprinted genes and transposable elements has been implicated in human disease and may be affected by maternal diet. OBJECTIVE: The objective was to determine the effect on offspring epigenetic status of nutritional and genetic factors that influence folate exposure in pregnancy. DESIGN: We measured folate intake ...
Wei Yi - - 2012
Cre-lox and other systems are used as genetic tools to control site-specific recombination (SSR) events in genomic DNA. If multiple recombination sites are organized in a compact cluster within the same genome, a series of random recombination events may generate substantial cell specific genomic diversity. This diversity is used, for ...
Yoshida Saran - - 2012
Abstract Background: The primary goals of this analysis were to explore the pros and cons of prognostic disclosure to patients and their families from the bereaved family's point of view. Methods: Semistructured interviews were conducted with 60 bereaved family members of patients with cancer in Japan. Results: There were eight ...
Ueda K - - 2012
BACKGROUND: /st>Cannulation of the radial artery in infants and small children can be challenging, even for the most experienced providers. Utilizing Doppler to aid in radial artery cannulation has been well described. Recent studies have demonstrated the efficacy of ultrasound (US) image-guided vascular access techniques in the paediatric population. The ...
Timmer Stefan A J - - 2012
Hypertrophic cardiomyopathy (HCM) is a major cause of sudden cardiac death in adolescence, and may lead to heart failure at any age. However, significant heterogeneity in the clinical course and phenotypic expression exists. Next to left ventricular hypertrophy, an impaired myocardial blood flow (MBF) during stress and inefficient cardiac metabolism ...
Hou Yang - - 2012
We report the design, synthesis and characterization of a novel heterojunction array of α-Fe2O3/graphene/BiV1-xMoxO4 core/shell nanorod for photoelectrochemical water splitting. The heterojunction array was prepared by hydrothermal deposition of α-Fe2O3 nanorods onto Ti substrate, with subsequent coating of graphene interlayer and BiV1-xMoxO4 shell by photocatalytic reduction and a spin-coating approach, ...
Ebrahimi Ardalan - - 2012
BACKGROUND: The purpose of this study was to determine whether the disease-free interval (DFI) between treatment of primary head and neck cutaneous squamous cell carcinoma (SCC) and the development of regional metastases is an independent prognostic factor. METHODS: A retrospective analysis of 229 patients with metastatic nodal head and neck ...
Steele Melanie - - 2012
We report a 2.5-month-old infant with bilateral adrenal neuroblastoma, stage 4S(M), with liver metastases and chemotherapy-induced veno-occlusive disease leading to cirrhosis requiring liver transplantation. Despite unknown tumour histology and MYCN-amplification status, we proceeded with liver transplant. This decision was based on clinical suspicion that our patient was MYCN-negative due to ...
Zhou Xiaodong - - 2012
The roles of biological springs in vertebrate animals and their implementations in compliant legged robots offer significant advantages over the rigid legged ones in certain types of scenarios. A large number of robotics institutes have been attempting to work in conjunction with biologists and incorporated these principles into the design ...
Sapède Dora - - 2012
In the inner ear, sensory versus neuronal specification is achieved through few well-defined bHLH transcription factors. However, the molecular mechanisms regulating the generation of the appropriate cell type in the correct place and at the correct time are not completely understood yet. Various studies have shown that hair cell- and ...
Choi Myoung Choul - - 2012
Despite the outstanding performance of Fourier transform ion cyclotron mass spectrometry (FTICR MS), the complexity of the cellular proteome or natural compounds presents considerable challenges. Sensitivity is a key performance parameter of a FTICR mass spectrometer. By improving this parameter, the dynamic range of the instrument can be increased to ...
Witt Torsten - - 2012
Chain (branch) length distributions (CLD) from size-exclusion chromatography of a series of waxy starches were parameterized using both an empirical and a biosynthesis-based method and correlated with their crystalline-amorphous lamellar properties obtained from X-ray scattering. Correlations were best seen with the biosynthesis-based parameterization. This showed for the first time that ...
Rockwell Nathan Clarke - - 2012
Phytochromes are red/far-red photoreceptors using cysteine-linked linear tetrapyrrole (bilin) chromophores to regulate biological responses to light. Light absorption triggers photoisomerization of the bilin between 15Z and 15E photostates. The related cyanobacteriochromes (CBCRs) extend the photosensory range of the phytochrome superfamily to shorter wavelengths of visible light. Several subfamilies of CBCRs ...
Brod Meryl - - 2012
Abstract Objective: To describe basal insulin analogue dosing irregularities, the effect of these events on patient functioning, well-being and diabetes management, and the identification of patients most at risk. Research design and methods: The GAPP2 (Global Attitude of Patients and Physicians 2) study was an online multinational cross-sectional study of ...
Masár Marián - - 2012
Adsorption processes on a polymethyl methacrylate (PMMA) chip linked with capillary zone electrophoresis (CZE) separations of a group of 13 aliphatic and aromatic mono- and diamines were studied. Due to the lack of chromophores within aliphatic amines, contact conductivity detection implemented directly onto the chip was used for monitoring of ...
Cabo R - - 2012
The avian Herbst corpuscles are the equivalent of the Pacinian corpuscles in mammals, and detect vibration and the movement of joints and feathers. Therefore, they can be regarded as rapidly adapting low-threshold mechanoreceptors. In recent years, it has been establish that some ion channels are involved in mechanosensation and are ...
Grothe Iris - - 2012
Receptive fields (RFs) of cortical sensory neurons increase in size along consecutive processing stages. When multiple stimuli are present in a large visual RF, a neuron typically responds to an attended stimulus as if only that stimulus were present. However, the mechanism by which a neuron selectively responds to a ...
Peña-Rodríguez Ovidio - - 2012
We have studied the evolution of dipole-dipole all-plasmonic Fano resonances (FRs) in symmetric multilayered nanoshells as a function of their geometrical parameters. We demonstrate that symmetry breaking is not mandatory for controlling the Fano resonance in such multilayer structures. By carefully selecting the geometrical parameters, the position of the FR ...
Hamprecht Axel - - 2012
OBJECTIVES: To characterize the mechanisms involved in reduced susceptibility to carbapenems in two Enterobacter cloacae clinical isolates. METHODS: Two E. cloacae isolates recovered from different regions in Germany and showing reduced susceptibility to carbapenems were analysed. Susceptibility testing, conjugation, transformation assays, plasmid analysis, sequencing and molecular typing using rep-PCR were ...
Vanderperren Katrien - - 2012
The extraction of task-related single trial ERP features has recently gained much interest, in particular in simultaneous EEG-fMRI applications. In this study, a specific decomposition known as parallel factor analysis (PARAFAC) was used, in order to retrieve the task-related activity from the raw signals. Using visual detection task data, acquired ...
Lee Vivian W Y - - 2012
BACKGROUND: Oral anticoagulation medications such as warfarin reduce the risk of stroke in atrial fibrillation (AF) but have been underutilized. This study aimed to investigate physicians' perceptions of stroke prevention management and patients' knowledge of AF and warfarin therapy in Hong Kong (HK). HYPOTHESIS: Both physician and patient's knowledge on ...
Stancl Marek - - 2012
A water-soluble methylene-bridged glycoluril dimer 2S was isolated. It was shown that 2S is only kinetic product of the reaction between glycoluril derivative 1 and paraformaldehyde. 2S is subsequently intermolecularly transformed into its diastereomer 2C. The kinetics and thermodynamics of the S- to C-shaped dimer isomerization were investigated under reaction ...
Du Yong - - 2012
BACKGROUND: Partial volume effects (PVEs) in PET imaging result in incorrect regional activity estimates due to both spill-out and spill-in from activity in neighboring regions. It is important to compensate for both effects to achieve accurate quantification. In this study, an image-based partial volume compensation (PVC) method was developed and ...
Hyza P - - 2012
We describe our experience and outcome with the 'Proximal first dorsal metacarpal artery free flap'. Ten consecutive cases utilizing the proximal first dorsal metacarpal artery free flap for complex digital defects were studied. Surgical technique, patient demographics, and flap outcome data were collected. Patient satisfaction was analysed using a questionnaire. ...
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