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Results 451 - 500 of 1761
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Papanikolaou Xenofon - - 2012
ABSTRACT: Extramedullary plasmacytomas constitute a rare and not well studied subset of MM relapses. We report the incidence, clinical-laboratory features and outcome of patients with MM and extramedullary relapse (ExMeR). 303 symptomatic MM patients were recorded in a thirteen years period in two institutions. 28 cases of ExMeR (9%) were ...
Saad Wael E A - - 2012
PURPOSE: This study describes and evaluated the effectiveness of occluding distal ureters in the clinical setting of urinary vaginal (vesicovaginal or enterovesicovaginal) fistulae utilizing a new technique which combines Amplatzer vascular plugs and N-butyl cyanoacrylate. MATERIALS: This is a retrospective study (January 2007-December 2010) of patients with urinary-vaginal fistulae undergoing ...
Riceberg Justin S - - 2012
Animals respond to changing contingencies to maximize reward. The orbitofrontal cortex (OFC) is important for flexible responding when established contingencies change, but the underlying cognitive mechanisms are debated. We tested rats with sham or OFC lesions in radial maze tasks that varied the frequency of contingency changes and measured both ...
Taig Efrat - - 2012
We tested cerebellar degeneration in human patients in a task designed to isolate different aspects of motor planning and found a specific relationship between their ability to do inverse kinematic transformation and sparing of Crus I. Our approach was based on an experimental design introduced by Sober and Sabes (2003, ...
Asselah Tarik - - 2012
Hepatitis C Virus (HCV) is a major cause of chronic liver disease worldwide. In addition to viral and environmental behavioral factors, host genetic diversity is believed to contribute to the spectrum of the disease. The sequencing of the human genome, together with the development of high-throughput technologies that measure the ...
Wang Yimin - - 2012
We report ab initio potential energy and dipole moment surfaces that span the regions describing the minima of trans and cis-HOCO and the barrier separating them. We use the new potential in three types of variational calculations of the vibrational eigenstates, for zero total angular momentum. Two use the code ...
Shan Aiqin - - 2012
Objective: To investigate the expression and clinical significance of both matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (tissue inhibitor of metalloproteinase-2 (TIMP-2)) in tunica media of radial artery in uremic patients. Methods: The modified radial arteries from 80 uremic patients during internal arteriovenous fistula surgery were selected and used as ...
Lu Dahua - - 2012
The CA3 area serves a key relay on the tri-synaptic loop of the hippocampal formation which supports multiple forms of mnemonic processing, especially spatial learning and memory. To date, morphometric data about human CA3 pyramidal neurons are relatively rare, with little information available for their pre- and postnatal development. Herein, ...
Rosengren Bert-Inge - - 2012
In peritoneal dialysis (PD) patients, the frequent exposure to "unphysiologic" dialysis fluids elicits a chronic state of a low-grade peritoneal inflammation leading to interstitial matrix remodeling and angiogenesis. Proinflammatory cytokines are important regulators involved in this inflammatory process that ultimately leads to dysfunction of the peritoneum as a dialysis membrane. ...
Cho H J HJ Cousins Center for Psychoneuroimmmunology, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA. - - 2013
Although basic research on neuroimmune interactions suggests that inflammatory processes may play a role in the development of fatigue, population-based evidence on this association is limited. This study examined whether plasma C-reactive protein (CRP) and interleukin-6 (IL-6), biomarkers of systemic inflammation, predict fatigue onset. The Whitehall II study is a ...
Mizoi Junya - - 2013
Soybean (Glycine max) is an important crop around the world. Abiotic stress conditions, such as drought and heat, adversely affect its survival, growth, and production. The DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN2 (DREB2) group includes transcription factors that contribute to drought and heat stress tolerance by activating transcription through the cis-element dehydration-responsive element ...
Layec Sabrina - - 2012
BACKGROUND: Segmental reversal of the small bowel (SRSB) is proposed in patients with short-bowel syndrome (SBS) as a rehabilitative therapy, but its effects on absorption have not been studied. OBJECTIVE: We aimed to determine intestinal macronutrient absorption and home parenteral nutrition (HPN) dependence in SBS patients with intestinal failure. DESIGN: ...
Zhang Lingyan - - 2012
Cyclin-dependent kinase 5(CDK5) in complex with its activator, p35 (protein of 35 kDa), is essential for early neurodevelopment in mammals. However, endogenous cleavage of p35 to p25 is associated with neuron death and neurodegenerative disease. Here we show that a peptide (p10') encoding the N-terminal domain of p35 protects against ...
Rodriguez Olga Catalina OC Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC - - 2012
The majority of human tumors express mutant forms of p53 at high levels, promoting gain of oncogenic functions and correlating with disease progression, resistance to therapy and unfavorable prognosis. p53 mutant accumulation in tumors is attributed to the ability to evade degradation by the proteasome, the only currently recognized machinery ...
Wijtmans Maikel - - 2012
The G protein-coupled chemokine receptor CXCR3 plays a role in numerous inflammatory events. The endogenous ligands for the chemokine receptors are peptides, but in this study we disclose small-molecule ligands that are able to activate CXCR3. A class of biaryl-type compounds that is assembled by convenient synthetic routes is described ...
Zhang Yu-Kun Jennifer YK Department of Pharmacology, University of Kansas Medical Center, Kansas City, KS, - - 2013
The nuclear receptor constitutive androstane receptor (CAR) is a key regulator for drug metabolism in liver. Human CAR (hCAR) transcripts are subjected to alternative splicing. Some hCAR splicing variants (SVs) have been shown to encode functional proteins by reporter assays. However, in vivo research on the activity of these hCAR ...
Białońska Agata - - 2012
[Fe(ebtz)(2)(C(2)H(5)CN)(2)](ClO(4))(2) was prepared in the reaction of 1,2-di(tetrazol-2-yl)ethane (ebtz) with Fe(ClO(4))(2)·6H(2)O in propionitrile. The compound crystallizes as a one-dimensional (1D) network, where bridging of neighboring iron(II) ions by two ebtz ligand molecules results in formation of a [Fe(ebtz)(2)](∞) polymeric skeleton. The 1D chains are assembled into supramolecular layers with axially ...
Trouillon Raphael - - 2012
An overview of methods developed for chemical analysis of single cells over the last two years is presented. Many biological systems contain an ensemble of cells with heterogeneous chemistry; therefore it is important to analyze them on an individual basis in order to elucidate the role each cell plays in ...
Tibbitt Mark W MW Department of Chemical and Biological Engineering, University of Colorado at Boulder, Boulder, CO 80309, - - 2012
The extracellular space, or cell microenvironment, choreographs cell behavior through myriad controlled signals, and aberrant cues can result in dysfunction and disease. For functional studies of human cell biology or expansion and delivery of cells for therapeutic purposes, scientists must decipher this intricate map of microenvironment biology and develop ways ...
Pennick M O - - 2012
Although first described almost half a century ago, parastomal varices are not easily recognised as a cause of stomal bleeding even though they occur in up to 5 % of all people who have a stoma. The main challenges associated with this condition are diagnosis and management. For that reason, the ...
Vallon Volker V Department of Medicine, University of California, San Diego, California 92161, USA. - - 2013
The Na-glucose cotransporter SGLT2 mediates high-capacity glucose uptake in the early proximal tubule and SGLT2 inhibitors are developed as new antidiabetic drugs. We used gene-targeted Sglt2 knockout (Sglt2(-/-)) mice to elucidate the contribution of SGLT2 to blood glucose control, glomerular hyperfiltration, kidney growth, and markers of renal growth and injury ...
Komlósi Gergely - - 2012
Selective serotonin reuptake inhibitors are the most widely prescribed drugs targeting the CNS with acute and chronic effects in cognitive, emotional and behavioral processes. This suggests that microcircuits of the human cerebral cortex are powerfully modulated by selective serotonin reuptake inhibitors, however, direct measurements of serotonergic regulation on human synaptic ...
Lauritzen Inger I Université de Nice-Sophia-Antipolis, Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 7275, Team Fondation pour la Recherche Médicale and Laboratoire d'Excellence Distalz, 06560 Sophia-Antipolis, - - 2012
Triple-transgenic mice (3xTgAD) overexpressing Swedish-mutated β-amyloid precursor protein (βAPP(swe)), P310L-Tau (Tau(P301L)), and physiological levels of M146V-presenilin-1 (PS1(M146V)) display extracellular amyloid-β peptides (Aβ) deposits and Tau tangles. More disputed is the observation that these mice accumulate intraneuronal Aβ that has been linked to synaptic dysfunction and cognitive deficits. Here, we provide ...
Jopling Chris - - 2012
BACKGROUND: Hypoxia plays an important role in many biological/pathological processes. In particular, hypoxia is associated with cardiac ischemia which, while initially inducing a protective response, will ultimately lead to the death of cardiomyocytes and loss of tissue, severely impacting cardiac functionality. While myocardial damage/loss remains an insurmountable problem for adult ...
Chang Cherylee W J - - 2012
OBJECTIVE: We report the clinical characteristics of the largest series of nontraumatic spinal cord injury in novice surfers (surfers' myelopathy). METHODS: A retrospective review of the electronic medical record was performed in patients with nontraumatic spinal cord injury associated with surfing identified upon admission to the largest tertiary referral hospital ...
Schlecker Eva - - 2012
Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of myeloid cells in cancer patients and tumor-bearing mice that potently inhibits T cell responses. During tumor progression, MDSCs accumulate in several organs, including the tumor tissue. So far, tumor-infiltrating MDSC subpopulations remain poorly explored. In this study, we performed global gene ...
Alby Kevin - - 2013
Using retrospective (n = 200) and prospective (n = 150) nasopharyngeal specimens, we evaluated the Nanosphere Verigene RV+ and the Focus Diagnostics Simplexa Flu A/B & RSV tests. Overall, RV+ demonstrated sensitivities and specificities of 96.6% and 100% for influenza A virus, 100% and 99.7% for influenza B virus, and ...
Thair Simone A - - 2012
ABSTRACT: In the previous issue of Critical Care, Maslove and colleagues studied circulating neutrophil transcriptional expression to discover and validate a molecular subclassification of adult patients with sepsis. The authors divided patients into small derivation (n = 55) and validation (n = 71) cohorts. Their complex methodology included partitioning around ...
Meckes David G DG Jr Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, - - 2013
The Epstein-Barr virus (EBV) is an important human pathogen that is associated with multiple cancers. The major oncoprotein of the virus, latent membrane protein 1 (LMP1), is essential for EBV B-cell immortalization and is sufficient to transform rodent fibroblasts. This viral transmembrane protein activates multiple cellular signaling pathways by engaging ...
Uchida Hiroaki - - 2013
Both entry and cell-to-cell spread of herpes simplex virus (HSV) involve a cascade of cooperative interactions among the essential glycoproteins D, B, and H/L (gD, gB, and gH/gL, respectively) initiated by the binding of gD to a cognate HSV entry receptor. We previously reported that a variant (D285N/A549T) of glycoprotein ...
Jakob Mark - - 2012
BACKGROUND: Mesenchymal stem cells (MSCs) are multipotent mesenchymal progenitor cells, originally identified in bone-marrow. Little is known about MSCs of the head and neck region. We investigated cell biological properties with a potential impact on wound healing of 2 different tissue-resident MSC populations. METHODS: MSCs were isolated from human nasal ...
Brownlee Ewan M - - 2012
Abstract Background: Improved cosmesis is widely recognized as the main benefit of single-port laparoscopy (SPL). Recently, some centers have started to perform SPL in infants and neonates. However, in our experience, the cosmetic result following traditional laparoscopic surgery in this age range is excellent. This study assessed infants' postoperative scars ...
Snow Samuel D - - 2012
The vast range of C60 derivatives makes it difficult to assess potential environmental impact of this class of materials, while past environmental studies mostly focused only on pristine C60. Central to derivatized C60's potential to negatively impact (micro)biological receptors upon unintended release is its unique property of mediating the transfer ...
Gonen Korcan Aysun - - 2012
BACKGROUND: Rickets is a complication of infantile osteopetrosis and pre-treatment recognition of this complication is important. OBJECTIVE: To describe four children with infantile osteopetrosis complicated by rickets (osteopetrorickets) and review the relevant literature. MATERIALS AND METHODS: Retrospective chart analysis of four infants with osteopetrorickets and a systematic review of the ...
Béjot Yannick - - 2012
OBJECTIVES: To investigate the premorbid use of secondary prevention medications in patients with recurrent vascular events. DESIGN: Prospective, observational, population based study. SETTING: The Dijon Stroke Registry and the registry of myocardial infarction of Dijon and Côte d'Or, France. PATIENTS: All patients with cerebral ischaemia (ischaemic stroke or transient ischaemic ...
Woo Patrick C Y - - 2013
We characterized 12 Exophiala strains isolated from patients over a 15-year period to the species level using phenotypic tests and internal transcribed spacer (ITS) and Rpb1 sequencing and described the clinical spectrum of the 12 patients. Eight patients had nail or skin infections, two had invasive infections, and two had ...
Ofri Danielle - - 2012
When a snarling Hurricane Sandy knocked the lights out at Bellevue Hospital Center on that Monday night, the staff murmured a collective chant: "One-Mississippi, two-Mississippi, three-Mississippi . . . ." We'd been told that if the electricity came back on before we hit "ten-Mississippi," then the backup generators were working fine. A ...
Andrew Amy J AJ Laboratory of Molecular Microbiology, Viral Biochemistry Section, NIAID, National Institutes of Health, Bethesda, Maryland 20892-0460, - - 2012
BST-2/CD317/tetherin is a host factor that inhibits HIV-1 release and is counteracted by HIV-1 Vpu. Structural studies indicate that the BST-2 ectodomain assumes a coiled-coil conformation. Here we studied the role of the BST-2 ectodomain for tethering function. First, we addressed the importance of the length and structure of the ...
Putzer Daniel - - 2012
PURPOSE: The aim of this study was to evaluate the impact of (68)Ga-labelled DOTA(0)-lanreotide ((68)Ga-DOTA-LAN) on the diagnostic assessment of neuroendocrine tumour (NET) patients with low to moderate uptake on planar somatostatin receptor (SSTR) scintigraphy or (68)Ga-labelled DOTA(0),Tyr(3)-octreotide ((68)Ga-DOTA-TOC) positron emission tomography (PET). METHODS: Fifty-three patients with histologically confirmed NET ...
Angus Scott V - - 2012
Cryptosporidium spp. is an obligate, parasitic protozoan that is difficult to detect and causes diarrhea in healthy adults while potentially causing death in the immunocompromised and children. Its treatment options are few and treat the symptoms, not the actual parasite. Current methods of detection are inefficient and rely too heavily ...
Karle William E - - 2012
BACKGROUND: For patients who have extensive prior treatment, use of the internal mammary artery/vein (IMA/IMV) or cephalic vein has been shown to be a reliable option. Additionally, for those patients who require vascularized bone and extensive soft tissue reconstruction, the combined latissimus dorsi scapular free flap (mega-flap) is an excellent ...
Gage Heather - - 2012
ABSTRACT: BACKGROUND: Older people living in care homes in England have complex health needs due to a range of medical conditions, mental health needs and frailty. Despite an increasing policy expectation that professionals should operate in an integrated way across organisational boundaries, there is a lack of understanding between care ...
Anderson Craig M - - 2012
Hetero-multinuclear, platinum/ruthenium species were synthesized and tested for their effect on the motility of A549 (nonsmall cell lung) and MDA-MB-231 (breast) cancer cells and for their ability to inhibit DNA mobility using gel electrophoresis. It was found that the Ru(2)Pt trinuclear species [Na(2)]{[Ru(III)Cl(4)(DMSO-S)(-μ-pyz)](2)Pt(II)Cl(2)}, AH197, was much more efficient at inhibiting ...
Ahmed Ishrat - - 2012
Parkinson's disease (PD) is a progressive neurodegenerative disease caused by the interaction of genetic and environmental factors. However, the etiology of PD remains largely unknown. Macroautophagy is known to play an essential role in the degradation of abnormal proteins and organelles. Furthermore, the loss of autophagy-related (Atg) genes results in ...
Christian Parul - - 2012
BACKGROUND: Micronutrient deficiencies may be related to poor fetal growth and short gestation. Few studies have investigated the contribution of maternal vitamin A deficiency to these outcomes. OBJECTIVE: In rural northwestern Bangladesh, we examined the effects of weekly antenatal vitamin A and β-carotene supplementation on birth weight, length, circumferential body ...
Bittencourt Danielle - - 2012
Histone H3 lysine-9 methyltransferase G9a/EHMT2/KMT1C is a key corepressor of gene expression. However, activation of a limited number of genes by G9a (independent of its catalytic activity) has also been observed, although the precise molecular mechanisms are unknown. By using RNAi in combination with gene expression microarray analysis, we found ...
Kubli Dieter A DA Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093-0758, - - 2013
It is known that loss-of-function mutations in the gene encoding Parkin lead to development of Parkinson disease. Recently, Parkin was found to play an important role in the removal of dysfunctional mitochondria via autophagy in neurons. Although Parkin is expressed in the heart, its functional role in this tissue is ...
Chen Pei - - 2012
Many studies have shown that pine needles are a good bio-monitor for atmospheric concentrations of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). However, this bio-monitor has not been tested in large areas, and the quantitative relationship between concentrations in pine needles and air has not been established. In the present ...
Enmi Jun-Ichiro - - 2012
In dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI), an arterial input function (AIF) is usually obtained from a time-concentration curve (TCC) of the cerebral artery. This study was aimed at developing an alternative technique for reconstructing AIF from TCCs of multiple brain regions. AIF was formulated by a multi-exponential function ...
Diamantopoulos Athanasios - - 2012
PURPOSE: Application of metal stents is complicated by neointimal hyperplasia leading to vessel restenosis and reocclusion. Treatment options in cases presenting with complete occlusion of the stented segment and recurrent critical limb ischemia (CLI) are limited. We present the option of the subintimal/substent technique in dealing with occluded stents. METHODS: ...
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