Search Results
Results 401 - 450 of 2028
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Powell David R - - 2012
Sodium-glucose cotransporter 2 (SGLT2) is the major, and SGLT1 the minor, transporter responsible for renal glucose reabsorption. Increasing urinary glucose excretion (UGE) by selectively inhibiting SGLT2 improves glycemic control in diabetic patients. We generated Sglt1 and Sglt2 knockout (KO) mice, Sglt1/Sglt2 double KO (DKO) mice, and wildtype (WT) littermates to ...
Yoshikawa Tadanobu - - 2012
Peripapillary and macular retinoschisis are usually associated with optic disc pits. We report a rare case of peripapillary retinoschisis with optic disc hypoplasia. A 59-year-old woman presented with asthenopia. Her best-corrected visual acuity was 20/20 OD. Ophthalmoscopy of the right eye revealed peripapillary retinoschisis, optic disc hypoplasia and dilated and ...
Asemi Zatollah - - 2012
Although gestational diabetes mellitus (GDM) is associated with an increased risk of maternal and neonatal morbidity, there is no consensus as to the optimal approach of nutritional management in these patients. The present study was designed to assess the effect of the Dietary Approaches to Stop Hypertension (DASH) eating plan ...
Cattaneo Zaira - - 2012
Visual stimuli that exhibit vertical symmetry are easier to remember than stimuli symmetric along other axes, an advantage that extends to the haptic modality as well. Critically, the vertical symmetry memory advantage has not been found in early blind individuals, despite their overall superior memory, as compared with sighted individuals, ...
Iervolino Vincenzo - - 2012
INTRODUCTION: Radiotherapy, alone or in combination with chemotherapy and/or surgery, is a fundamental and irreplaceable method of treating tumours. Nonetheless, although the technological advances made during recent years and the associated improvements in this type of treatment have reduced the incidence of complications, 5-15 % of patients still experience damage to ...
Jagtap Krishna K - - 2012
Bodipy laser dyes are highly efficient but degrade rapidly in solution by reacting with in situ generated singlet oxygen ((1) O(2) ). To increase the lasing lifetimes of these dyes, we have designed and synthesised two different congeners of the widely studied Pyrromethene 567 (PM567) by substitution at the boron centre ...
Batabyal Subrata - - 2012
We investigate picosecond-resolved energy transfer between a quantum dot (donor) and an organic molecule (acceptor) in the proximity of a reflecting metallic/non-metallic surface. We demonstrate experimentally that the Förster resonance energy transfer (FRET) is significantly influenced by the proximity of the mirror. Locating a cadmium selenide quantum dot (donor: D) ...
Shankar Lalitha K - - 2012
The National Cancer Institute (NCI) has a long-standing interest in evaluating and using the known advantages of molecular and functional imaging, as well as assessing the potential of novel imaging agents and modalities, to improve clinical cancer research and cancer care. In this Perspectives article, I discuss the strategies and ...
Singh Bharti - - 2012
With the objective of understanding the role of size and current level of filamentary regions on the resistive switching parameters, detailed conductive atomic force microscope investigations of resistive memory cells having different dimensions have been carried out in this study. Cu-Cu(2)O-Ti memory cells having dimensions of 150, 50 and 25 μm ...
Sera Nobuko - - 2012
Atomic bomb (A-bomb) radiation is associated with cardiovascular disease (CVD) and metabolic CVD risk factors. Chronic kidney disease (CKD) is also known to be a risk factor for CVD and little is known whether CKD is associated with A-bomb radiation. To examine whether CKD is associated with CVD risk factors ...
Hill Jeff T - - 2012
Both classical and quantum systems utilize the interaction of light and matter across a wide range of energies. These systems are often not naturally compatible with one another and require a means of converting photons of dissimilar wavelengths to combine and exploit their different strengths. Here we theoretically propose and ...
Shang Yanwei - - 2012
Superhydrophobic and superoleophilic nanofibrous membranes exhibiting robust oil-water separation performance were prepared by a facile combination of electrospun cellulose acetate (CA) nanofibers and a novel in situ polymerized fluorinated polybenzoxazine (F-PBZ) functional layer that incorporated silica nanoparticles (SiO(2) NPs). By employing the F-PBZ/SiO(2) NPs modification, the pristine hydrophilic CA nanofibrous ...
Huang Han-Bin - - 2012
BACKGROUND: Exposure to traffic-related air pollutants, including polycyclic aromatic hydrocarbons (PAHs) and heavy metals, has been associated with the etiology and prognosis of many illnesses. However, the specific causal agents and underlying mechanisms for different health outcomes remain unclear. The aims of this study were to assess the relations between ...
Ciborowski Michal - - 2012
Ozonated autohemotherapy (O(3)-AHT) is a medical approach during which blood obtained from the patient is ozonated and injected back into the body. Despite an increasing number of evidences that O(3)-AHT is safe, this type of therapy remains controversial. To extend knowledge about the changes in blood evoked by O(3)-AHT LC-MS ...
Noguera Aina - - 2012
ABSTRACT: BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is characterized by an enhanced inflammatory response to smoking that persists despite quitting. The resolution of inflammation (catabasis) is a complex and highly regulated process where tissue resident macrophages play a key role since they phagocytose apoptotic cells (efferocytosis), preventing their secondary necrosis ...
Joya Yasir F - - 2012
Anatase-based titanium dioxide (TiO(2)) naturally possesses a well recognized antibacterial effect under ultraviolet excitation. However, anatase modified with silver nanoparticles (Ag NPs) exhibits even stronger antibacterial action in natural daylight. The purpose of our present research is to evaluate the photocatalytic antibacterial effects of laser-generated silver-anatase nanocomposite film against Escherichia ...
Behringer Karolin - - 2012
PURPOSETo optimize fertility advice in patients with Hodgkin lymphoma (HL) before therapy and during survivorship, information on the impact of chemotherapy is needed. Therefore, we analyzed gonadal functions in survivors of HL. PATIENTS AND METHODSWomen younger than age 40 and men younger than 50 years at diagnosis in ongoing remission ...
Hammond Ceri - - 2012
The partial oxidation of methane to methanol presents one of the most challenging targets in catalysis. Although this is the focus of much research, until recently, approaches had proceeded at low catalytic rates (<10 h(-1) ), not resulted in a closed catalytic cycle, or were unable to produce methanol with a ...
Hurcombe Samuel D - - 2012
OBJECTIVE: To document whether presumptive bacterial translocation (PBT) occurs in horses with small intestinal strangulation (SIS). DESIGN: Prospective clinical cohort study. SETTING: University tertiary care facility. ANIMALS: Thirty-six adult horses with SIS (clinical cases) and 10 adult horses without gastrointestinal disease (control cases). INTERVENTIONS: Sterile collection and bacterial culture of ...
Pool Stefan Ernest - - 2012
Inhibition of mTOR (mammalian target of rapamycin) is commonly considered a valid target in cancer treatment, but this assertion does not address effects on the immune microenvironment that may be detrimental to cancer treatment. Here we show how administration of the mTOR inhibitor RAD001 (everlimus) results in occurrence of distant ...
Jadidi Faramarz - - 2012
Abstract Objective. To determine the effect of contingent electrical stimulation (CES) on jaw muscle activity during sleep in a double-blinded randomized controlled trial (RCT). Materials and methods. Eleven patients with myofascial TMD (mean age 37 years) and with a clinical diagnosis of bruxism were included. EMG activity (Grindcare®) was recorded ...
Kandolin Riina - - 2012
BACKGROUND: -Giant cell myocarditis (GCM) often escapes diagnosis until autopsy or trans-plantation and has defied proper treatment trials for its rarity and deadly behavior. Current therapy rests on multiple-drug immunosuppression but its prognostic influence remains poorly known. We set out to analyze 1) our experience in diagnosing GCM and 2) ...
Naqshbandi Masood - - 2012
Manufacturing complex composites and structures using incompatible materials is central to next-generation technologies. In photonics, silica offers passivity, low loss and robustness, making it the ideal material platform for optical transport. However, these properties partly stem from the high-temperature processing conditions necessary for silica waveguide fabrication, restricting the functionalisation of ...
Nombela-Franco Luis - - 2012
BACKGROUND: The objective of this study was to evaluate the timing, predictive factors and prognostic value of cerebrovascular events (CVEs) following transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: The study included 1061 consecutive patients who underwent TAVI with a balloon- (64%) or a self- (36%) expandable valve. CVEs were ...
Schramm Charlotte - - 2012
BACKGROUND: Congenital anterior staphyloma is a rare, complex malformation syndrome of the anterior segment. Only a few reports on associated systemic malformations have been published. We herein present a rare manifestation of congenital anterior staphyloma (CAS) combined with amniotic band disruption syndrome (ABS). PATIENT AND METHODS: Shortly after birth, a ...
Begeman L - - 2012
Intestinal volvulus was recognized as the cause of death in 18 cetaceans, including 8 species of toothed whales (suborder Odontoceti). Cases originated from 11 institutions from around the world and included both captive (n = 9) and free-ranging (n = 9) animals. When the clinical history was available (n = ...
Mora Sandeep - - 2012
Cellulosic sludge from paper mills making bleached products can be enzymatically converted to glucose. A kinetic model that accounts for product inhibition was used to estimate the cost:benefits of the process. In the proposed scheme, the sludge is enzymatically hydrolyzed in a sequence of CSTRs, the ash separated, and the ...
Verho Oscar - - 2012
By using a dimeric ruthenium complex in combination with tert-butyl hydrogen peroxide (TBHP) as stoichiometric oxidant, a mild and efficient protocol for the oxidation of secondary benzylic alcohols was obtained, thereby giving the corresponding ketones in high yields within 4 h. However, in the oxidation of aliphatic alcohols, the TBHP protocol ...
Robins Richard S - - 2012
Gas6 (growth-arrest specific gene 6) plays a role in thrombus stabilization. Gas6 null (-/-) mice are protected from lethal venous and arterial thromboembolism through platelet signalling defects induced only by 5 µM ADP and 10 µM of the thromboxane analogue, U46619. This subtle platelet defect, despite a dramatic clinical phenotype, ...
Amlal Hassane - - 2012
Apical chloride secretory pathways in the kidney medullary collecting duct are thought to play an important role in the modulation of final urine composition and regulation of systemic vascular volume and/or blood pressure. However, the molecular identity of these molecules has largely remained unknown. Here, we demonstrate that Slc26a9, an ...
Guerrero Alma D - - 2012
Latino toddlers fall behind White peers at 24 months of age in oral language and interactive skills with their mothers in English or Spanish. But Latino children enter kindergarten with social skills that rival White peers, despite social-class disparities. We ask whether cognitive trajectories widen during the 24-48 month period, how these ...
Li Feng - - 2012
This paper reports the effects of linker length on electron propagation through ferrocene moieties covalently anchored onto insulator-based cylindrical nanopores derived from a cylinder-forming polystyrene-poly(methylmethacrylate) diblock copolymer. These nanopores (24 nm in diameter, 30 nm long) aligned perpendicular to an underlying gold electrode were modified via esterification of their surface ...
Ranthe Mattis Flyvholm - - 2012
AimsDescriptive and genetic studies suggest that relatives of sudden cardiac death (SCD) victims have an increased risk of several cardiovascular diseases (CVDs). Given the severe consequences of undiagnosed CVD and the availability of effective treatment, the potential for prevention in this group is enormous if they do have an increased ...
Cañete-Valdeón José M - - 2012
There is a growing interest in mathematical mechanistic modelling as a promising strategy for understanding tumour progression. This approach is accompanied by a methodological change of making research, in which models help to actively generate hypotheses instead of waiting for general principles to become apparent once sufficient data are accumulated. ...
Daughtry Kelly D - - 2012
Lanthanide-binding tags (LBTs), peptide-based coexpression tags with high affinity for lanthanide ions, have previously been applied as luminescent probes to provide phasing for structure determination in X-ray crystallography and to provide restraints for structural refinement and distance information in NMR. The native affinity of LBTs for Gd(3+) indicates their potential ...
Velez-Fort Emilio - - 2012
Nitrogen doping of graphene is of great interest for both fundamental research, to explore the effect of dopants on a 2D electrical conductor, and applications such as lithium storage, composites and nanoelectronic devices. Here, we report on the modifications of the electronic properties of epitaxial graphene thanks to the introduction, ...
Shen Li-Tao - - 2012
Cinchona alkaloids were used as Lewis base catalysts in the title reaction. The [4+2] cyclization of α,β-unsaturated acyl chlorides with electron-deficient alkenes derived from oxindole gave the corresponding spirocarbocyclic oxindoles.
Khan A J - - 2012
BACKGROUND: Shorter courses of APBI, including single-fraction intraoperative therapy, are under active investigation. We designed a prospective trial to identify and address the potential radiobiological and logistical shortcomings of single-fraction APBI. METHODS: We designed a single-arm, multi-institutional, prospective phase II trial that sequentially treats 3 cohorts of women (each n = 30) ...
Conibear Anne C - - 2012
The θ-defensins are, to date, the only known ribosomally-synthesised cyclic peptides in mammals and they have promising antimicrobial bioactivities. The characteristic structural motif of the θ-defensins is the cyclic cystine ladder, comprising a cyclic peptide backbone and three parallel disulfide bonds. In contrast to the cyclic cystine knot, which characterises ...
Wijnen Petal A - - 2012
BACKGROUND: Fibrosing interstitial pneumonias (IPs) include idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP). It has been suggested that oxidative damage plays a role in the pathophysiology of idiopathic interstitial pneumonias. Diffuse alveolar hemorrhage (DAH) can cause oxidative stress. Accordingly, we hypothesized that episodes of DAH might trigger fibrosing ...
Kulkarni M A - - 2012
SUMMARY Encephalitis is a clinical syndrome often associated with infectious agents. This study describes the epidemiology and disease burden associated with encephalitis in Canada and explores possible associations with arboviral causes. Encephalitis-associated hospitalizations, 1994-2008, were analysed according to aetiological category (based on ICD-9/ICD-10 codes) and other factors using multivariate logistic ...
Wang Rui - - 2012
PURPOSEThe RET fusion gene has been recently described in a subset of non-small-cell lung cancers (NSCLCs). Because we have limited knowledge about these tumors, this study was aimed at determining the clinicopathologic characteristics of patients with NSCLC harboring the RET fusion gene. PATIENTS AND METHODSWe examined the RET fusion gene ...
He Zuoli - - 2012
Anatase type nitrogen-fluorine (N-F) co-doped TiO2 nanobelts were successfully prepared by a solvothermal method, which amorphous titania microspheres were used as the precursors. The as-prepared TiO2 nanobelts are composed of thin narrow nanobelts, and it is noted that there are large amount of wormhole-like mesopores on these narrow nanobelts. Photocatalytic ...
Sincer Isa - - 2012
Aortic stiffness is increased in patients with sustained hypertension (SH). The aim of this study was to investigate the relationship between aortic elastic properties and masked hypertension (MH). We evaluated aortic elastic properties in 35 individuals with MH, 35 patients with SH, and 35 normotensive healthy volunteers using transthoracic Doppler ...
Dhouib Amira - - 2012
Although rare, inflammatory myofibroblastic tumor is the most common primary lung mass in children. We report the case of an 11-year-old boy investigated for persistent cough and dyspnea with complete left lung atelectasis mimicking pneumonia. CT and MRI showed an endobronchial mass of the left main bronchus. The boy underwent ...
Farkas Joel - - 2012
Methods for efficient growth and manipulation of relatively uncharacterized bacteria facilitate their study and are essential for genetic manipulation. We report new growth media and culture techniques for Caldicellulosiruptor bescii, the most thermophilic cellulolytic bacterium known. A low osmolarity defined growth medium (LOD) was developed that avoids problems associated with ...
Epstein Samuel - - 2012
We extend the semi-least squares problem defined by Rao and Mitra (1971) to the kernel semi-least squares problem. We introduce subset projection, a technique that produces a solution to this problem. We show how the results of subset projection can be used to approximate a computationally expensive distance metric.
Nadella Sandeep - - 2012
Phenanthroline-based hexadentate ligands L(1) and L(2) bearing two achiral semicarbazone or two chiral imine moieties as well as the respective mononuclear complexes incorporating various lanthanide ions, such as La(III) , Eu(III) , Tb(III) , Lu(III) , and Y(III) metal ions, were synthesized, and the crystal structures of [ML(1) Cl(3) ] ...
Zhong Miao - - 2012
A single crystal domain texture quality (a unique in-plane and out-of-plane crystalline orientation over a large area) ZnO nanostructure of a dense nanowire array on a thick film has been homogeneously synthesized on a-plane sapphire substrates over large areas through a one-step chemical vapor deposition (CVD) process. The growth mechanism ...
Ho Ming-Yi - - 2012
More effective treatments for metastatic lung cancer remain a pressing clinical need. In this study we identified MIG-7 protein as critical for COX-2/PGE2- and Akt/GSK-3β-dependent tumor invasion/metastasis. COX-2/PGE2 activated EP4 to enhance Akt and GSK-3β phosphorylation and β-catenin/LEF/TCF signaling leading to MIG-7 upregulation. RNAi-mediated attenuation of MIG-7 blocked COX-2/PGE2- and ...
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