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Results 401 - 450 of 2032
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Laforest Laurent - - 2012
Tiotropium is an innovative intervention in chronic obstructive pulmonary disease (COPD). Early adherence to tiotropium remains inadequately explored, notably time from initiation to discontinuation (persistence). In patients with COPD, the factors associated with the risk of discontinuing the treatment with tiotropium within 12 months following initiation were identified (12-month persistence). ...
Gaudio Pasquale Del - - 2012
In this study, a novel preparation method for alginate-based aerogels charged with nonsteroidal anti-inflammatory drugs (NSAIDs) was developed using prilling in combination with supercritical fluid technique. Nanoporous carriers were prepared by laminar jet breakup of drug/alginate solutions or suspensions followed by cross-linking in ethanol or aqueous CaCl(2) solutions, water replacement, ...
Gu Xun Wendy - - 2012
We report the synthesis, mechanical properties and deformation mechanisms of polycrystalline, platinum nanocylinders of grain size d=12nm. The number of grains across the diameter, D/d, was varied from 5 to 80 and 1.5 to 5 in the experiments and molecular dynamics simulations, respectively. An abrupt weakening is observed at a ...
Yang Yang Y State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, - - 2013
Polycomb group protein PHF1 is well known as a component of a novel EED-EZH2·Polycomb repressive complex 2 complex and plays important roles in H3K27 methylation and Hox gene silencing. PHF1 is also involved in the response to DNA double-strand breaks in human cells, promotes nonhomologous end-joining processes through interaction with ...
Kolesnikova Tatyana D - - 2012
Drosophila SUUR (Suppressor of UnderReplication) protein was shown to regulate the DNA replication elongation process in endocycling cells. This protein is also known to be the component of silent chromatin in polyploid and diploid cells. To mark the different cell cycle stages, we used immunostaining patterns of PCNA, the main ...
Chang Alicia H AH Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California 94305, USA. - - 2013
Beginning in 2005, the Centers for Disease Control and Prevention (CDC) expanded the overseas presumptive treatment of intestinal parasites with albendazole to include refugees from the Middle East. We surveyed the prevalence of helminths and protozoa in recent Middle Eastern refugees (2008-2010) in comparison with refugees from other geographical regions ...
Oehme Daniel P - - 2012
X-ray crystallography studies have identified that most cyclic inhibitors of HIV protease (including cyclic ureas) bind in a symmetric manner, however some cyclic inhibitors, such as cyclic sulfamides, bind in a non-symmetric manner. This raises the question as to whether it is possible for cyclic sulfamides to bind symmetrically and ...
Cadzow Renee B - - 2012
PurposeThe purpose of this study was to evaluate a community-based diabetes education pilot project. The Neighborhood Health Talker project aimed to train and implement cultural health brokers primarily targeting communities of color to improve community members' diabetes knowledge and diabetes self-management skills. A secondary aim was to establish diabetes resource ...
Didiot Marie-Cecile - - 2012
Translation initiation is a fine-tuned process that plays a critical role in tumorigenesis. The use of small molecules that modulate mRNA translation provides tool compounds to explore the mechanism of translational initiation and to further validate protein synthesis as a potential pharmaceutical target for cancer therapeutics. This report describes the ...
Smits Marianne - - 2012
Photocatalytic soot oxidation is studied on P25 TiO(2) as an important model reaction for self-cleaning processes by means of electron paramagnetic resonance (EPR) and Fourier transform infrared (FTIR) spectroscopy. Contacting of carbon black with P25 leads on the one hand to a reduction of the local dioxygen concentration in the ...
Knott Brandon C - - 2012
Methane hydrates are ice-like inclusion compounds with importance to the oil and natural gas industry, global climate change, and gas transportation and storage. The molecular mechanism by which these compounds form at conditions relevant to industry and nature remains mysterious. To understand the mechanism of methane hydrate nucleation from supersaturated ...
von Sarnowski Bettina B Department of Neurology, University Medicine, Ferdinand-Sauerbruch-Straße, D-17475 Greifswald, Germany. - - 2013
Although many stroke patients are young or middle-aged, risk factor profiles in these age groups are poorly understood. The Stroke in Young Fabry Patients (sifap1) study prospectively recruited a large multinational European cohort of patients with cerebrovascular events aged 18 to 55 years to establish their prevalence of Fabry disease. ...
Boivin Andrée-Anne - - 2012
The immunosuppressive drug tacrolimus requires strict therapeutic monitoring due to its narrow therapeutic index and high interindividual variability. Organic anion transporting polypeptide 1B3 (OATP1B3) is a human hepatocyte transporter involved in the hepatobiliary elimination of diverse endogenous and exogenous substances. Genetic variations within the solute carrier (SLCO) 1B3 gene that ...
Cybulski C C Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Połabska 4, Szczecin 70-115, - - 2013
To establish the contribution of eight founder alleles in three DNA damage repair genes (BRCA1, CHEK2 and NBS1) to prostate cancer in Poland, and to measure the impact of these variants on survival among patients. Three thousand seven hundred fifty men with prostate cancer and 3956 cancer-free controls were genotyped ...
Paschoal Diego - - 2012
In this paper, we assessed the quantum mechanical level of theory for prediction of linear and nonlinear optical (NLO) properties of push-pull organic molecules. The electric dipole moment (μ), mean polarizability ([Symbol: see text]α[Symbol: see text]) and total static first hyperpolarizability (β(t)) were calculated for a set of benzene, styrene, ...
Chen Xianzhong - - 2012
Surface topography and refractive index profile dictate the deterministic functionality of a lens. The polarity of most lenses reported so far, that is, either positive (convex) or negative (concave), depends on the curvatures of the interfaces. Here we experimentally demonstrate a counter-intuitive dual-polarity flat lens based on helicity-dependent phase discontinuities ...
Djamil John - - 2012
Carbon containing nano-sized molybdenum sulfide composites (MoS(x)C(y)) obtained by thermal decomposition reactions of (R(4)N)(2)MoS(4) (R = -H (C(0)), -CH(3) (C(1)), -C(3)H(7) (C(3)), and -C(6)H(13) (C(6))) show promising performance in visible-light driven photocatalytic hydrogen generation.
Badham Stephen P - - 2012
Criminal suspects with distinctive facial features, such as tattoos or bruising, may stand out in a police lineup. To prevent suspects from being unfairly identified on the basis of their distinctive feature, the police often manipulate lineup images to ensure that all of the members appear similar. Recent research shows ...
Hwang Heeyong - - 2012
CAPs off to the S-S bond: Application of a strategy involving the introduction of intramolecular disulfide bonds to amphipathic cationic antimicrobial peptides (CAPs) led to decreased α-helicity and hydrophobicity. The mutant peptides were observed to have significantly increased (250-fold) minimum hemolytic concentrations while maintaining MIC values against E. coli, affording more ...
Kolychev Eugene L - - 2012
Tris[3,5-bis(trifluoromethyl)phenyl]borane reacts with the sterically demanding Arduengo carbenes 1,3-di-tert-butylimidazolin-2-ylidene and 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene to form isolable normal adducts. In the case of 1,3-di-tert-butylimidazolin-2-ylidene, the adduct exhibits dynamic behaviour in solution and frustrated-Lewis-pair (FLP) reactivity. Fast cleavage of dihydrogen and THF, the CH activation of phenylacetylene, and carbon dioxide fixation were achieved by ...
Matuskova Miroslava - - 2012
BACKGROUND: Engineered mesenchymal stromal cells (MSC) were used in many preclinical studies of gene directed enzyme/prodrug therapy. We aimed to compare the efficacy of two most frequently used systems, and evaluate extent of bystander effect mediated by therapeutic MSC towards cell lines derived from different tumours. METHODS: Two approaches were ...
Seng Sonia - - 2012
Several reports suggest that cisplatin is associated with an increased risk of thromboembolism. However, because the excess risk of venous thromboembolic events (VTEs) with cisplatin-based chemotherapy has not been well described, we conducted a systemic review and meta-analysis of randomized controlled trials evaluating the incidence and risk of VTEs associated ...
Huan Jianya - - 2012
Extrinsic signaling cues in the microenvironment of acute myeloid leukemia (AML) contribute to disease progression and therapy resistance. Yet it remains unknown how the bone marrow niche where AML arises is subverted to support leukemic persistence at the expense of homeostatic function. Exosomes are cell membrane-derived vesicles carrying protein and ...
Solimeo Renee L - - 2012
Regulatory agencies require testing of chemicals and products to protect workers and consumers from potential eye injury hazards. Animal screening, such as the rabbit Draize test, for potential environmental toxicants is time-consuming and costly. Therefore, virtual screening using computational models to tag potential ocular toxicants is attractive to toxicologists and ...
D'Ercole Loredana - - 2012
PURPOSE: To measure the maximum entrance skin dose (MESD) on patients undergoing carotid artery stenting (CAS) using embolic-protection devices, to analyze the dependence of dose and exposure parameters on anatomical, clinical, and technical factors affecting the procedure complexity, to obtain some local diagnostic reference levels (DRLs), and to evaluate whether ...
Laowansiri Utumporn - - 2012
Abstract Objective: To describe maxillary growth and maturation during infancy and early childhood. Materials and Methods: Serial cephalograms (N  =  210) of 30 subjects (15 females and 15 males) from the Bolton-Brush Growth Study were analyzed. Each subject had a series of six consecutive cephalograms taken between birth and 5 years ...
Yamamoto Manabu - - 2012
BACKGROUND: In the decade after the 1945 atomic bombing of Hiroshima, a high incidence of leukemia was observed among atomic bomb survivors. However, the incidence of other cancers gradually increased, while that of leukemia decreased after this period. We evaluated the clinical outcome of early gastric cancer and microsatellite stability ...
Otosaka Shigeyoshi - - 2012
Sedimentation and remobilization processes of radiocesium were investigated from time-series observations at nine stations in the coastal area of Ibaraki, 70-110 km south of the Fukushima Dai-ichi Nuclear Power Plant (1FNPP). Sediment samples were collected four times between June 2011 and January 2012, and concentrations of radiocesium as well as sediment ...
Jensen Pernille Linnert - - 2012
Human embryonic stem cells (hESCs) are derived from the inner cell mass (ICM) of the blastocyst and can differentiate into any cell type in the human body. These cells hold a great potential for regenerative medicine, but in order to obtain enough cells needed for medical treatment, culture is required ...
Ti Lianping - - 2012
Peer-based models for human immunodeficiency virus (HIV) testing have been implemented to increase access to testing in various settings. However, little is known about the acceptability of peer-delivered testing and counseling among people who inject drugs (IDU). During July and October 2011, data derived from the Mitsampan Community Research Project ...
Kumar Pradeep - - 2012
The search for new and efficient ways to synthesize optically pure compounds is an active area of research in organic synthesis. Asymmetric catalysis provides a practical, cost-effective, and efficient method to create a variety of complex natural products containing multiple stereocenters. In recent years, chemists have become more interested in ...
Wang Feng - - 2012
Expectations for the next generation of lithium batteries include greater energy and power densities along with a substantial increase in both calendar and cycle life. Developing new materials to meet these goals requires a better understanding of how electrodes function by tracking physical and chemical changes of active components in ...
Joy Elizabeth Liz - - 2013
Physical activity (PA) is a key component of healthy lifestyle and disease prevention. In contrast, physical inactivity accounts for a significant proportion of premature deaths worldwide. Physicians are in a critical position to help patients develop healthy lifestyles by actively counseling on PA. Sports medicine physicians, with their focus on ...
Sporea Ioana - - 2012
We introduce a supervised learning algorithm for multilayer spiking neural networks. The algorithm overcomes a limitation of existing learning algorithms: it can be applied to neurons firing multiple spikes in artificial neural networks with hidden layers. It can also, in principle, be used with any linearizable neuron model and allows ...
Schroeder Natalia Mariel - - 2012
Dilemmas of natural resources governance have been a central concern for scholars, policy makers, and users. Major debates occur over the implications of property rights for common resources management. After the Mexican Revolution (1910-1917), land was distributed mainly as ejidos conceived as a hereditary but unalienable collective form of property. ...
Nagaraja Mamta Patel - - 2012
Bone loss is a well documented phenomenon occurring in humans both in short and in long term spaceflights. This phenomenon can be also reproduced on the ground in human and animals and also modeled in cell-based analogs. Since space flights are infrequent and expensive to study the biomedical effects of ...
Zhang X Y - - 2012
BACKGROUND: Although patients with chronic schizophrenia have substantially higher smoking rates than either the general population or patients with other mental illnesses, drug-naive patients with a first episode of schizophrenia have received little systemic study. This study examined smoking rates, the association between smoking and symptom severity and cognitive function ...
Lerner Jennifer S JS Harvard University, Harvard Kennedy School, Cambridge, MA 02138, USA. - - 2013
We hypothesized a phenomenon that we term myopic misery. According to our hypothesis, sadness increases impatience and creates a myopic focus on obtaining money immediately instead of later. This focus, in turn, increases intertemporal discount rates and thereby produces substantial financial costs. In three experiments, we randomly assigned participants to ...
Amlal Hassane - - 2012
Apical chloride secretory pathways in the kidney medullary collecting duct are thought to play an important role in the modulation of final urine composition and regulation of systemic vascular volume and/or blood pressure. However, the molecular identity of these molecules has largely remained unknown. Here, we demonstrate that Slc26a9, an ...
Guerrero Alma D - - 2012
Latino toddlers fall behind White peers at 24 months of age in oral language and interactive skills with their mothers in English or Spanish. But Latino children enter kindergarten with social skills that rival White peers, despite social-class disparities. We ask whether cognitive trajectories widen during the 24-48 month period, how these ...
Kain Jamey S - - 2012
Drosophila typically move toward light (phototax positively) when startled. The various species of Drosophila exhibit some variation in their respective mean phototactic behaviors; however, it is not clear to what extent genetically identical individuals within each species behave idiosyncratically. Such behavioral individuality has indeed been observed in laboratory arthropods; however, ...
Zhao Qinjian - - 2012
There is emerging evidence for an under-recognized hepatitis E virus (HEV) as a human pathogen. Among different reasons for this neglect are the unsatisfactory performance and under-utilization of commercial HEV diagnostic kits; for instance, the number of anti-HEV IgM kits marketed in China is about one-fifth of that of hepatitis ...
Li Feng - - 2012
This paper reports the effects of linker length on electron propagation through ferrocene moieties covalently anchored onto insulator-based cylindrical nanopores derived from a cylinder-forming polystyrene-poly(methylmethacrylate) diblock copolymer. These nanopores (24 nm in diameter, 30 nm long) aligned perpendicular to an underlying gold electrode were modified via esterification of their surface ...
Ranthe Mattis Flyvholm - - 2012
AimsDescriptive and genetic studies suggest that relatives of sudden cardiac death (SCD) victims have an increased risk of several cardiovascular diseases (CVDs). Given the severe consequences of undiagnosed CVD and the availability of effective treatment, the potential for prevention in this group is enormous if they do have an increased ...
Cañete-Valdeón José M - - 2012
There is a growing interest in mathematical mechanistic modelling as a promising strategy for understanding tumour progression. This approach is accompanied by a methodological change of making research, in which models help to actively generate hypotheses instead of waiting for general principles to become apparent once sufficient data are accumulated. ...
Daughtry Kelly D - - 2012
Lanthanide-binding tags (LBTs), peptide-based coexpression tags with high affinity for lanthanide ions, have previously been applied as luminescent probes to provide phasing for structure determination in X-ray crystallography and to provide restraints for structural refinement and distance information in NMR. The native affinity of LBTs for Gd(3+) indicates their potential ...
Velez-Fort Emilio - - 2012
Nitrogen doping of graphene is of great interest for both fundamental research, to explore the effect of dopants on a 2D electrical conductor, and applications such as lithium storage, composites and nanoelectronic devices. Here, we report on the modifications of the electronic properties of epitaxial graphene thanks to the introduction, ...
Valdés Raquel R Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, - - 2012
Equilibrative nucleoside transporters are a unique family of proteins that enable uptake of nucleosides/nucleobases into a wide range of eukaryotes and internalize a myriad of drugs used in the treatment of cancer, heart disease, AIDs, and parasitic infections. In previous work we generated a structural model for such a transporter, ...
Shen Li-Tao - - 2012
Cinchona alkaloids were used as Lewis base catalysts in the title reaction. The [4+2] cyclization of α,β-unsaturated acyl chlorides with electron-deficient alkenes derived from oxindole gave the corresponding spirocarbocyclic oxindoles.
Khan A J - - 2012
BACKGROUND: Shorter courses of APBI, including single-fraction intraoperative therapy, are under active investigation. We designed a prospective trial to identify and address the potential radiobiological and logistical shortcomings of single-fraction APBI. METHODS: We designed a single-arm, multi-institutional, prospective phase II trial that sequentially treats 3 cohorts of women (each n = 30) ...
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