Search Results
Results 201 - 250 of 2028
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Morota G - - 2012
Linkage disequilibrium (LD) is defined as a non-random association of the distributions of alleles at different loci within a population. This association between loci is valuable in prediction of quantitative traits in animals and plants and in genome-wide association studies. A question that arises is whether standard metrics such as ...
Prades J M - - 2012
PURPOSE: The aim of the current study was to analyze some parameters that are involved in nerve conduction in the right and left recurrent laryngeal nerves (RLNs) in humans. We have studied two morphological parameters such as the length of the two nerves, and the total intraperineural area (TIPA) from ...
Wang Hom-Lay - - 2012
BACKGROUND:: Implants were first designed to be used in the reconstruction of edentulous mandibles. However, with the technological advancement, enormous changes were made to improve the implant design and surface characteristics leading to the wide use of implants in the replacement of missing teeth. During the transition from an edentulous ...
Dwyer Tim - - 2012
Knee dislocations are rare and potentially devastating injuries. Significant displacement of the tibia and femur commonly disrupts multiple knee ligaments and also often results in profound disruption to the surrounding soft tissue envelope. Open wounds and neurologic and vascular insult can put the involved limb in jeopardy. Following reduction, the ...
Rossi A - - 2012
AIM:This work has the aim to test the sensibility of VSCAPSI method in the evaluation of effectiveness of a medicated shampoo for the treatment of scalp psoriasis. Psoriasis is a chronic inflammatory skin disease histologically characterized by proliferation and loss of differentiation of keratinocytes, angiogenesis with vasodilatation and increased permeability, ...
Tuchscherer A - - 2012
For some purposes, identity-by-descent (IBD) probabilities for entire chromosome segments are required. Making use of pedigree information, length of the segment and the assumption of no crossing-over, a generalization of a previously published graph theory oriented algorithm accounting for nonzero IBD of common ancestors is given, which can be viewed ...
Margari Lucia - - 2012
Background Ophthalmoplegic migraine (OM) is a rare condition characterized by the association of headaches and an oculomotor nerve palsy. The third cranial nerve is commonly involved in recurrent attacks, whereas involvement of the sixth and fourth nerves is uncommon. It is still debated whether an uncontrolled migraine or an oculomotor ...
D ľavolio Antonio - - 2012
OBJECTIVES:: The response rate to treatment of chronic hepatitis C virus-genotype 1 and 4 infections was recently found to be strongly influenced by many polymorphisms. The aim of our study was to carry out an integrated analysis of the effects of polymorphisms and ribavirin (RBV) plasma exposure on outcome. METHODS:: ...
Zhang Qiu-Xiang - - 2012
The purposes of this study were to investigate the physiological mechanism of stimulus-evoked fast intrinsic optical signals (IOSs) recorded in dynamic confocal imaging of the retina, and to demonstrate the feasibility of in vivo confocal IOS mapping of localized retinal dysfunctions. A rapid line-scan confocal ophthalmoscope was constructed to achieve ...
Tezel Gülgün - - 2012
Evidence supporting the immune system involvement in glaucoma includes increased titers of serum antibodies to retina and optic nerve proteins, although their pathogenic importance remains unclear. This study using an antibody-based proteomics approach aimed to identify disease-related antigens as candidate biomarkers of glaucoma. Serum samples were collected from 111 patients ...
Lee Jiwoon - - 2012
To identify recessive mutations affecting development and/or maintenance of the zebrafish visual system. A three-generation ENU (N-Nitroso-N-ethylurea)-based forward genetic screen was performed. F3 embryos were screened visually from 1 to 5 days postfertilization (dpf) for ocular abnormalities, and 5 dpf embryos were fixed and processed for cryosectioning, after which eye ...
Chou Tsung-Han - - 2012
To compare the bioelectric field associated with the pattern electroretinogram (PERG) with that of the flash electroretinogram (FERG) in the mouse. PERGs and FERGs were recorded from each eye in 32 C57BL/6J mice using corneal silver loops referenced to a subcutaneous needle on the back of the head. PERG stimuli ...
Lim Wayland W Division of Cardiovascular Medicine, Department of Internal Medicine, University of California (Davis) Medical Center, 4860 Y Street, Sacramento, CA 95817, - - 2012
This report presents a 55-year-old man admitted for respiratory failure, who was found to have a brief run of polymorphic ventricular tachycardia (PVT) with normal QT interval. The importance of differentiating PVT caused by torsades de pointes and PVT with normal QT interval is emphasized. This distinction is crucial because ...
Brensilver Matthew M Department of Family Medicine, David Geffen School of Medicine at UCLA, CA 90095, - - 2012
Chronic noncancer pain (CNCP) affects many primary care patients, and carries a large human and economic burden. In response to the widespread perception that pain is underdiagnosed and undertreated, regulatory bodies have encouraged more comprehensive services to address pain syndromes. Significant hurdles exist in treating CNCP in primary care settings, ...
Huang Pei-Hsiu PH Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, - - 2012
Patients commonly undergo noncardiac surgical procedures after implantation of a coronary stent. In the case where surgery cannot be deferred until completing the minimum duration of dual antiplatelet therapy, the Brigham and Women's Hospital Cardiac Catheterization Laboratory recommends using a glycoprotein IIb/IIIa bridging protocol to minimize the risk of perioperative ...
Branham Kari K Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, Michigan 48105, - - 2012
To determine the proportion of male patients presenting simplex retinal degenerative disease (RD: retinitis pigmentosa [RP] or cone/cone-rod dystrophy [COD/CORD]) with mutations in the X-linked retinal degeneration genes RPGR and RP2. Simplex males were defined as patients with no known affected family members. Patients were excluded if they had a ...
Bholat Michelle Anne MA UCLA Family Health Center, Santa Monica, CA 90404, USA. - - 2012
The health care system in the United States is inefficient and there are many incentives for sustainable changes in the delivery of care. Incorporating behavioral medicine offers a wide range of opportunities. Within primary care settings, pain disorders, addiction, depression, and anxiety disorders are highly prevalent. Numerous chronic health conditions ...
Haywood Philip P Centre for Health Economics Research and Evaluation, University of Technology Sydney, NSW, Australia. - - 2012
The increasing cost of chemotherapy is placing greater pressures on limited healthcare budgets. A potentially important, but often overlooked, aspect of chemotherapy is the cost associated with administration. This study aims to develop a better understanding of these costs, and in doing so, develop a model to estimate the comparative ...
Cho Yang Kyung YK Department of Ophthalmology, University of Utah School of Medicine, Salt Lake City, Utah, - - 2012
This study sought to determine whether a Vascular Endothelial Growth Factor Receptor 1 (VEGFR1)-specific morpholino (MO) could decrease neovascularization, thereby enhancing murine cornea transplant survival, and if this effect is synergistic with steroid therapy. Graft survival, corneal neovascularization, and corneal lymphangiogenesis were compared among the VEGFR1_MO, STD MO and PBS ...
Büyüktimkin Barlas B Department of Pharmaceutical Chemistry, The University of Kansas, Simons Research Laboratories, 2095 Constant Avenue, Lawrence, Kansas 66047, United - - 2013
The objective of this work is to utilize novel I-domain antigenic-peptide conjugates (IDAC) for targeting antigenic peptides to antigen-presenting cells (APC) to simulate tolerance in experimental autoimmune encephalomyelitis (EAE). IDAC-1 and IDAC-3 molecules are conjugates between the I-domain protein and PLP-Cys and Ac-PLP-Cys-NH(2) peptides, respectively, tethered to N-terminus and Lys ...
Kandasamy Jeyakumar J The Edith and Joseph Fischer Enzyme Inhibitors Laboratory, Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 32000, - - 2012
Compelling evidence is now available that gentamicin and Geneticin (G418) can induce the mammalian ribosome to suppress disease-causing nonsense mutations and partially restore the expression of functional proteins. However, toxicity and relative lack of efficacy at subtoxic doses limit the use of gentamicin for suppression therapy. Although G418 exhibits the ...
Jagadish Bhumasamudram B Department of Chemistry and Biochemistry, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85721-0041, United - - 2012
The synthesis and structure-activity relationships of a homologous series of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid gadolinium(III) complexes bearing thiol-terminated alkyl side chains from three to nine carbons in length are reported. The observed binding with human serum albumin (HSA) of the compounds having C-3 through C-7 side chain lengths was inhibited by homocysteine ...
Moore Theodore C TC Department of Bacteriology, University of Wisconsin, Madison, WI 53706, - - 2012
ATP:co(I)rrinoid adenosyltransferases (ACATs) are enzymes that catalyze the formation of adenosylcobalamin (AdoCbl, coenzyme B(12)) from cobalamin and ATP. There are three families of ACATs, namely, CobA, EutT, and PduO. In Salmonella enterica, CobA is the housekeeping enzyme that is required for de novo AdoCbl synthesis and for salvaging incomplete precursors ...
Mishra Vidhi V Department of Chemistry, University of Toledo, Toledo, OH 43606, - - 2012
The bacterial 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) enzyme is a multifunctional enzyme that catalyzes the hydrolysis of the N-ribosidic bond of at least four different adenosine-based metabolites: S-adenosylhomocysteine (SAH), 5'-methylthioadenosine (MTA), 5'-deoxyadenosine (5'-DOA), and 6-amino-6-deoxyfutalosine. These activities place the enzyme at the hub of seven fundamental bacterial metabolic pathways: S-adenosylmethionine (SAM) utilization, ...
Serang Oliver O Department of Neurobiology, Harvard Medical School Children's Hospital Boston, Boston, Massachusetts, United States. - - 2012
Parsimony and protein grouping are widely employed to enforce economy in the number of identified proteins, with the goal of increasing the quality and reliability of protein identifications; however, in a counterintuitive manner, parsimony and protein grouping may actually decrease the reproducibility and interpretability of protein identifications. We present a ...
Tyurin Vladimir A VA Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260, USA. - - 2012
Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing characteristic of high specificity for oxidatively modified sn-2 fatty acid residues in phospholipids that has been especially well characterized for peroxidized species of phosphatidylcholines (PC). The ability of Lp-PLA(2) to hydrolyze peroxidized species of ...
Smith Clyde A CA Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California 94025, United States. - - 2012
Carbapenem antibiotics have become therapeutics of last resort for the treatment of difficult infections. The emergence of class-A β-lactamases that have the ability to inactivate carbapenems in the past few years is a disconcerting clinical development in light of the diminished options for treatment of infections. A member of the ...
Fakhrian K - - 2012
PURPOSE: To report the efficacy and toxicity of radio(chemo)therapy (RCT) in the management of squamous cell anal carcinoma (SQ-AC) and to evaluate the prognostic factors influencing the outcomes. PATIENTS AND METHODS: A consecutive cohort of 138 patients with cT1-4, cN0-3, cM0 SQ-AC were treated with RCT between 1988 and 2011 ...
Yang Benson P - - 2012
STUDY DESIGN.: Institutional review board-approved, prospective, multicenter, comparative study. OBJECTIVE.: To assess the accuracy and utility of a computer-assisted fluoroscopic navigation method for percutaneous placement of lumbar pedicle screws compared with conventional fluoroscopic placement. SUMMARY OF BACKGROUND DATA.: Recent reports indicate that cortical breaches during percutaneous pedicle screw placement can ...
Morgan Garry T - - 2012
We have investigated the association of DNA methylation and proteins interpreting methylation state with the distinctive closed and open chromatin structural domains that are directly observable in the lampbrush chromosomes (LBCs) of amphibian oocytes. To establish the distribution in LBCs of MeCP2, one of the key proteins binding 5-methylcytosine-modified DNA ...
Jackisch T - - 2012
The majority of proctological diseases can be defined by a structured evaluation of the symptoms and a physical examination. Magnetic resonance imaging (MRI) and anal endosonography can detect complex anal fistulas with a high accuracy but MRI should be preferred because of its objective visualization. Functional anorectal disorders are multifactorial ...
Panneerselvam Lakshmikanthan - - 2012
The present study is aimed to evaluate the protective effect of ferulic acid (FA) on fluoride-induced oxidative hepatotoxicity in male Wistar rats. Fluoride (25 mg/L) was given orally to induce hepatotoxicity for 12 weeks. Hepatic damage were assessed using status of pathophysiological markers like serum marker enzymes like aspartate transaminase, alanine transaminase, ...
Gao Bixia - - 2012
Anti-glomerular basement membrane (anti-GBM) disease is characterized by autoantibodies against antigenic site on type IV collagen of the GBM. The coexistence of anti-GBM disease and other immune complex mediated glomerulonephritis is common. Herein, we describe a patient presented with rapidly progressive glomerulonephritis, who was diagnosed as IgA-mediated nephropathy and was ...
Reyes-Moreno Cuauhtémoc - - 2012
The objective of this study was to determine the best combination of extrusion process variables for the production of whole quality protein maize (EQPMF) and common bean (ECBF) flours to prepare a high antioxidant activity mixture (EQPMF + ECBF) suitable to produce a nutraceutical beverage with high acceptability elaborated with ...
Thomas Rachel N - - 2012
This study examined attitudes about outcomes associated with childhood gender nonconformity. Participants were 518 undergraduate students (337 female; 181 male) at a midwestern university in the U.S. Participants were presented with 1 of 10 vignettes describing a target child (male or female) who varied in gendered traits, interests, and behaviors ...
Ma Mengtao - - 2012
Reactions of [Pt(PCy(3))(2)] (Cy = cyclohexyl) with group 12 metal dihalides have afforded the novel metal only Lewis pair (MOLP) complexes, [(Cy(3)P)(2)Pt→MX(2)] (M = Zn or Cd, X = Br or I), or the oxidative addition product, trans-[(Cy(3)P)(2)(I)PtHgI]. The zinc complex represents the first MOLP to contain an unsupported Pt→Zn ...
Liu Dan-Dan - - 2012
Measurements of the advancing contact angle ( ) and adsorption properties were carried out for aqueous solutions of four cationic surfactants, hexadecanol glycidyl ether ammonium chloride (C16PC), guerbet alcohol hexadecyl glycidyl ether ammonium chloride (C16GPC), hexadecanol polyoxyethylene(3) glycidyl ether ammonium chloride(C16(EO)3PC) and guerbet alcohol hexadecyl polyoxyethylene(3) glycidyl ether ammonium chloride ...
Roth Bodil - - 2012
Abstract Objective. Microscopic colitis (MC) and irritable bowel syndrome (IBS) are both gastrointestinal disorders with female predominance that affect well-being. Autoantibodies against gonadotropin-releasing hormone (GnRH) have recently been detected in IBS patients. The purpose of this study was to compare gastrointestinal symptoms and well-being in MC female outpatients, with or ...
Azuma Junichi - - 2012
OBJECTIVE: This study is a pharmacogenetic clinical trial designed to clarify whether the N-acetyltransferase 2 gene (NAT2) genotype-guided dosing of isoniazid improves the tolerability and efficacy of the 6-month four-drug standard regimen for newly diagnosed pulmonary tuberculosis. METHODS: In a multicenter, parallel, randomized, and controlled trial with a PROBE design, ...
Márquez Javier - - 2012
Glutamine/glutamate homeostasis must be exquisitely regulated in mammalian brain and glutaminase (GA, E.C. 3.5.1.2) is one of the main enzymes involved. The products of GA reaction, glutamate and ammonia, are essential metabolites for energy and biosynthetic purposes but they are also hazardous compounds at concentrations beyond their normal physiological thresholds. ...
Tehrani Hiva - - 2012
Objective. Aluminum phosphide is used as a fumigant. It produces phosphine gas (PH(3)). PH(3) is a mitochondrial poison which inhibits cytochrome c oxidase, it leads to generation of reactive oxygen species; so one of the most important suggested mechanisms for its toxicity is induction of oxidative stress. In this regard, ...
Bettoli Vincenzo - - 2012
Abstract The chemoprevention of non-melanoma skin cancer refers to the use of various types of chemical agents for preventing carcinogenic progression, particularly in high-risk population. Retinoids are the most studied, among the possible chemopreventive agents, due to their capacity to regulate cell proliferation and their demonstrated efficacy in several clinical ...
Dulin David - - 2012
To understand genomic processes such as transcription, translation or splicing, we need to be able to study their spatial and temporal organization at the molecular level. Single-molecule approaches provide this opportunity, allowing researchers to monitor molecular conformations, interactions or diffusion quantitatively and in real time in purified systems and in ...
Isgrò M - - 2012
The C-C motif chemokine ligand 5 (CCL5), CCL11, and CCL24 are involved in the pathogenesis of asthma, and their function is mainly associated with the airway recruitment of eosinophils. This study tested their ability to induce the migration of circulating fibrocytes, which may contribute to the development of irreversible airflow ...
Parkinson Lynne - - 2012
The usefulness of chiropractic for treatment of low back pain is a contentious issue. Chiropractors advocate holism and general well-being as a key principle on which they base their clinical practice, yet the quality of life, lifestyle, health and economic impacts of chiropractic intervention for back pain in adults have ...
Chen Hualin - - 2012
Leather tanneries around the world, including China, introduce chromium (Cr) and other metals into the environment. In China, the population pressure compels the utilization of every piece of available land for food production. In this study, we investigated the content, leachability and possible storage sinks for Cr and other metals ...
Lv Jian - - 2012
Recently, chiral Brønsted acids as dual ligand and acid catalysts in the context of metal catalysis have been developed. Such binary catalytic systems synergistically integrate chiral Brønsted acids and metal catalysts as a result of their weakly coordinating behaviors. The resulting binary acid catalysts have enabled effective reactions of a ...
Davis S R - - 2012
ABSTRACT Background: The profound estrogen depletion caused by aromatase inhibitors (AIs) is associated with musculoskeletal symptoms, but the underlying pathophysiology remains unclear. Objective: To assess the effects of AI therapy on structural changes in knee cartilage and subchondral bone over 2 years in postmenopausal women. Setting and Participants: 30 women ...
Manderscheid Niko - - 2012
Elaiomycins K and L, two new azoxy-type antibiotics, were detected by HPLC-diode array screening in the culture filtrate extract of Streptomyces sp. Tü 6399. The structures were determined by high-resolution MS and 2-dimensional (1)H and (13)C correlated NMR spectroscopy including (15)N-NMR experiments and established these compounds as new members of ...
Wolfs T G A M - - 2012
Ureaplasma infection of the amniotic cavity is associated with adverse postnatal intestinal outcomes. We tested whether interleukin-1 (IL-1) signaling underlies intestinal pathology following ureaplasma exposure in fetal sheep. Pregnant ewes received intra-amniotic injections of ureaplasma or culture media for controls at 3, 7, and 14 d before preterm delivery at 124 d ...
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