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Results 701 - 750 of 2028
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Yu Heng-Yi - - 2012
Two new tetrahydrofuran lignans, schiglaucin A and B (1-2), together with eight known analogues (3-10), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic techniques (HRESIMS, UV, IR, NMR, and CD experiments). All of the compounds were tested for their neuroprotective ...
Mothi S N - - 2012
The term "Adolescence" literally means "to emerge" or "to attain identity" and is essentially the period of rapid physical and psychological development starting from the onset of puberty to complete growth. All adolescents go through a myriad of physical, psychological, neurobehavioural, hormonal and social developmental changes. Given the social taboos ...
Beaumont Elodie - - 2012
The development of a prophylactic vaccine against hepatitis C virus (HCV) has become an important medical priority, as three to four million new HCV infections are thought to occur each year worldwide. The hepatitis B virus (HBV) is another major human pathogen, but infections with this virus can be prevented ...
Gui T - - 2012
OBJECTIVE: The aims of this study are to summarize our experience of managing ovarian malignancy complicating pregnancy, to discuss the maternal and fetal outcomes, and to review the literature concerned. METHODS: Forty-one patients with ovarian malignancies complicating pregnancy at Peking Union Medical College Hospital between 1990 and 2012 were retrospectively ...
Versluis Maarten J - - 2012
PURPOSE: To determine the subjective experiences and the sources of discomfort for subjects undergoing 7 T magnetic resonance imaging (MRI) examinations on a whole-body 7 T system in a hospital setting MATERIALS AND METHODS: A postscan survey was filled out by 101 healthy subjects who participated in a 7 T ...
Yadollahi Azadeh - - 2012
Tracheal respiratory sound analysis is a simple and non-invasive way to study the pathophysiology of the upper airway and has recently been used for acoustic estimation of respiratory flow and sleep apnea diagnosis. However in none of the previous studies was the respiratory flow-sound relationship studied in people with obstructive ...
Conyers Ryan C - - 2012
With the use of benzonitrile-stabilized Au(I) catalyst [Au(IPr)(NCPh)]SbF(6) (Ic; IPr=1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene), a spectrum of reactivity is observed for propargyl ester 4 a with cyclic vinyl ethers, ranging from exclusively [3C+2C] cycloaddition reactions to exclusively cyclopropanation depending only on the structure of the substrate. Some initially formed cyclopropanation products rearrange into the corresponding ...
Lee Sumin - - 2012
An open and shut case: Photoirradiation of the 9-mesityl-10-methylacridinium ion, which acts as a photoredox catalyst, evoked catalytic cycloreversion of the photochromic 1,2-dithienylethene (DTE) compounds with one order of magnitude enhancement in quantum yields. Mechanistic studies revealed that the back electron transfer and electron transfer from the neutral closed form ...
Na Chan Woong - - 2012
Single-crystalline Mn3O4 nanowires were prepared using the vapor-phase transformation of ZnO nanobelts. Mn3O4-decorated ZnO nanobelts and ZnO-ZnMn2O4 core-shell nanocables (NCs) were also obtained as reaction intermediates. Heteroepitaxial growth of tetragonal spinel Mn3O4 (or ZnMn2O4) on wurtzite ZnO is a possible reason for the growth of single-crystalline Mn3O4 nanowires. Growth interfaces ...
Vácha Robert - - 2012
During passive endocytosis, nanosized particles are initially encapsulated by a membrane separating it from the cytosol. Yet, in many applications the nanoparticles need to be in direct contact with the cytosol in order to be active. We report a simulation study that elucidates the physical mechanisms by which such nanoparticles ...
Zheng Xiaoming - - 2012
This work studies a fundamental problem in blood capillary growth: how the cell proliferation or death induces the stress response and the capillary extension or regression. We develop a one-dimensional viscoelastic model of blood capillary extension/regression under nonlinear friction with surroundings, analyze its solution properties, and simulate various growth patterns ...
Barochiner Jessica - - 2012
We assessed prevalence and clinical characteristics of resistant hypertension (RH) and prevalence of false RH (white-coat effect [WCE] by home blood pressure [BP] monitoring), among a population of 302 treated hypertensive patients, mean age 66.6 (±13.8), 67.5% women. Resistant hypertension was defined according to the American Heart Association criteria. Prevalence ...
Liu Jia - - 2012
Chirality-controlled synthesis of single-wall carbon nanotubes with predefined chiralities has been an important but elusive goal for almost two decades. Here we demonstrate a general strategy for producing carbon nanotubes with predefined chiralities by using purified single-chirality nanotubes as seeds for subsequent metal catalyst free growth, resembling vapour-phase epitaxy commonly ...
Yang Lei - - 2012
The hydrothermal reactions of α-K(4)SiW(12)O(40) with NiCl(2)·6H(2)O yielded two unprecedented silicotungstates containing a triangular inorganic Ni(6) core. Furthermore, Na(2)[Ni(6)(μ(3)-OH)(3)(H(2)O)(9)SiW(9)O(34)](2)·17H(2)O () presents a rare dimer, in which two SiW(9) units sandwich double Ni(6) cores by W-O-Ni linking instead of conventional Ni-O-Ni.
Massaro Allie M - - 2012
A 36-year-old woman with Sheehan syndrome was found unresponsive. Evaluation was consistent with Addisonian crisis and myxedema coma. Continuous EEG demonstrated right frontotemporal nonconvulsive status initially refractory to multiple antiepileptic drugs (figure 1).
Huang Chiung-Kuei - - 2012
Transplantation of bone marrow mesenchymal stem cells (BM-MSCs) has been considered as an alternative therapy, replacing liver transplantation in clinical trials, to treat liver cirrhosis, an irreversible disease that may eventually lead to liver cancer development. However, low survival rate of the BM-MSCs leading to un-satisfactory efficacy remains a major ...
Al Attia Haider M - - 2012
In the UAE, 255 women with different dressing styles (veiled and non-veiled) underwent assay for vitamin D(3). The vitamin level was suboptimal in all groups including those dressed in Western style. The contribution of hypovitaminosis D to osteoporosis was less impressive compared to that of age factor. INTRODUCTION: Vitamin D ...
Daly Christopher - - 2012
The angiopoietins Ang1 (ANGPT1) and Ang2 (ANGPT2) are secreted factors that bind to the endothelial cell-specific receptor tyrosine kinase Tie2 (TEK) and regulate angiogenesis. Ang1 activates Tie2 to promote blood vessel maturation and stabilization. In contrast, Ang2, which is highly expressed by tumor endothelial cells, is thought to inhibit Tie2 ...
Kallupi Marsida - - 2012
RATIONALE: Previous studies have shown that activation of brain neuropeptide S receptor (NPSR) facilitates reinstatement of cocaine seeking elicited by environmental cues predictive of drug availability. This finding suggests the possibility that blockade of NPSR receptors may be of therapeutic benefit in cocaine addiction. To evaluate this hypothesis, we investigated ...
Budohoski Karol P - - 2012
BACKGROUND AND PURPOSE: Delayed cerebral ischemia (DCI) is a recognized contributor to unfavorable outcome after subarachnoid hemorrhage (SAH). Recent data challenge the concept of vasospasm as the sole cause of ischemia and suggest a multifactorial process with dysfunctional cerebral autoregulation as a component. We tested the hypothesis that early autoregulatory ...
Wakamatsu Tais H - - 2012
PURPOSE: To evaluate the levels of lipid oxidative stress markers and inflammatory cells from tears and conjunctiva of patients with Sjogren Syndrome (SS) and normal subjects. METHODS: Thirty-one eyes of 16 patients (16 females) with SS and 15 eyes of 10 healthy controls (2 males and 8 females) were examined ...
Hajiebrahimi Mohammad Hossein - - 2012
Placental weight may be regarded as an indirect marker of hormone exposures during pregnancy. There is epidemiological evidence that breast cancer mortality in premenopausal women increases with placental weight in the most recent pregnancy. We investigated if this association differs by tumor characteristics, including expression of estrogen and progesterone receptors. ...
De Santis Ferreira Leandro - - 2012
Tetrahydrofuran lignans represent a well-known group of phenolic compounds capable of acting as antiparasitic agents. In the search for new medicines for the treatment of Chagas disease, one promising compound is grandisin which has shown significant activity on trypomastigote forms of Trypanosoma cruzi. In this work, the in vitro metabolism ...
Jankowska Joanna - - 2012
The proton-transfer reaction in a model aromatic Schiff base, salicylidene methylamine (SMA), in the ground and in the lowest electronically-excited singlet states, is theoretically analyzed with the aid of second-order approximate coupled-cluster model CC2, time-dependent density functional theory (TD-DFT) using the Becke, three-parameter Lee-Yang-Parr (B3LYP) functional, and complete active space ...
De Bock Lies - - 2012
To improve modelling and simulation of the pharmacokinetics (PK) in paediatric patients, there is a need for research on developmental and disease-specific determinants. This article describes the evaluation of the in vitro cytochrome P450 activity, an important enzyme family in drug metabolism, in children with hepatic dysfunction. The activity of ...
Macías Francisco A - - 2012
Commercially available santonin was used to synthesize seven sesquiterpene lactones using a facile strategy that involved a high-yielding photochemical reaction. Three natural products from Artemisia gorgonum were synthesized in good yields, and in the case of two compounds, absolute configurations were determined from X-ray quality crystals. The structures previously reported ...
Shaheen Farzana - - 2012
Cherimolacyclopeptide E (1) is a cyclic hexapeptide obtained from Annona cherimola, reported to be cytotoxic against the KB (human nasopharyngeal carcinoma) cell line. The solid-phase total syntheses of this cyclic peptide and its analogues were accomplished by employing FMOC/tert-butyl-protected amino acids and the Kenner sulfonamide safety-catch linker. The synthetic peptide ...
Gernsheimer Terry - - 2012
A mild thrombocytopenia is relatively frequent during pregnancy and has generally no consequences for either the mother or the fetus. Although representing no threat in the majority of patients, thrombocytopenia may result from a range of pathologic conditions requiring closer monitoring and possible therapy. Two clinical scenarios are particularly relevant ...
Aifa Abdelouahab - - 2012
PURPOSE: Neurotrophic keratopathy is a degenerative disease of the corneal epithelium resulting from impaired corneal innervation, possibly leading to perforation. We aimed to assess the efficacy and tolerance of a new matrix therapy agent (RGTA, CACICOL20), mimicking heparan-sulfates, for the management of neurotrophic keratopathy. Methods: We carried out an uncontrolled, ...
Gauss T - - 2012
BACKGROUND: Perioperative coordination facilitates team communication and planning. The aim of this study was to determine how often deviation from predicted surgical conditions and a pre-established anaesthetic care plan in major abdominal surgery occurred, and whether this was associated with an increase in adverse clinical events. METHODS: In this prospective ...
Hanna Kathleen M - - 2012
PurposeThe purpose of the study was to examine the association of time (high school to post-high school), living situation (independent of parents or not), diabetes-specific self-efficacy, and worry about hypoglycemia and how diabetes-specific self-efficacy and worry about hypoglycemia are associated with diabetes management among emerging adults with type 1 diabetes.MethodsParticipants ...
Viguié Catherine - - 2012
The putative thyroid-disrupting properties of bisphenol A (BPA) highlight the need for an evaluation of fetal exposure and its consequence on the mother/newborn thyroid functions in models relevant to human. The goals of this study were to characterize in sheep a relevant model for human pregnancy and thyroid physiology, the ...
Godfray H Charles J - - 2012
Mosquitoes transmit some of the most important infectious diseases of man including malaria that today kills around 0·6-1·2 million people a year, the majority children in low-income countries. There is increasing realisation that no single intervention is likely to halt malaria and a multipronged approach is needed including vector control. Very ...
Lipton Richard B - - 2012
BACKGROUND: While nausea is a defining feature of migraine, the association of nausea with other headache features and its influence on the burden of migraine have not been quantified. Population-based data were used to elucidate the relative frequency and burden of migraine-associated nausea in persons with migraine. METHODS: Participants with ...
Rekik Amira - - 2012
'In connection with the Taparura Project, we studied the distribution of phytoplankton and zooplankton communities in relation to environmental variables at 18 stations sampled during four coastal cruises conducted between October 2009 and July 2010 on the north coast of Sfax (Tunisia, western Mediterranean Sea). The inshore location was largely ...
Hall Charlotte L - - 2012
Gaze patterns to figure images have been proposed to reflect the observer's sexual interest, particularly for men. This eye-tracking study investigated how individual differences in sexual motivation tendencies are manifested in naturalistic gaze patterns. Heterosexual men and women (M = 21.0 years, SD = 2.1) free-viewed plain-clothed male and female figures, aged 10, 20, ...
Nakajima Makoto - - 2012
BACKGROUND AND PURPOSE: Diffusion-weighted imaging can depict secondary signal change of the substantia nigra of patients with ipsilateral striatal infarction via a decrease in the apparent diffusion coefficient (ADC). Clinical predictors of this phenomenon remain unclear. METHODS: We assessed 98 stroke patients with acute ischemic lesions in the hemilateral basal ...
Horsman Michael R - - 2012
Reduced oxygen levels (hypoxia) is one of the most important factors influencing clinical outcome after radiotherapy. This is primarily because hypoxic cells are resistant to radiation treatment; hence, the greater the number of clonogenic cancer stem cells that exist under hypoxia, the lower the local tumour control. Reduced local control ...
Wang Xiaoying - - 2012
In this study, an attempt was made to prepare novel D-glucosamine hydrochloride-rectorite (DGH-REC) nanocomposites with improved antioxidant and anti-ultraviolet activity via the solution-intercalation method. The structure and morphology of DGH-REC nanocomposites were characterized by XRD, TEM, (13)C CP/MAS NMR, FT-IR, XPS and SEM. The results showed that the interlayer distance ...
Lobayan Rosana M - - 2012
The TRA (3-[2-aminoethyl]indole) is an important neurotransmitter with a close structural and chemical similarity to the neurotransmitter serotonin (5-hydroxytryptamine), and to melatonin (5-methoxy-N-acetyltryptamine), which plays a key role in daily human behavior. Moreover, TRA, and other indolic compounds are very efficient antioxidants. In this work the conformational space of TRA ...
Pianezzola E - - 2012
Arion vulgaris Moquin-Tandon 1855 is one of the most important invasive species in Europe, affecting both biodiversity and agriculture. The species is spreading in many parts of Europe, inflicting severe damage to horticultural plants and cultivated crops partly due to a lack of satisfactory and effective management solutions. Molluscicides have ...
Depew Zachary S - - 2012
Objectively measured severe physical inactivity (SPI) has been reported as the strongest independent predictor of mortality in patients with chronic obstructive pulmonary disease (COPD). Activity monitoring is not feasible in routine clinical practice; therefore, we set out to determine the utility of simple clinical measures for predicting SPI in patients ...
Cheng Ting-Jen R - - 2012
The wizard of OS (resistance): The binding difference of neuraminidase inhibitors (zanamivir versus oseltamivir (OS)) was used to establish an assay to identify the influenza subtypes that are resistant to OS but still sensitive to zanamivir. This assay used a zanamivir-biotin conjugate to determine the OS susceptibility of a wide ...
Landy Stephen H - - 2012
OBJECTIVE: To assess the ability of patients, during an acute migraine attack, to successfully self-inject a single dose of sumatriptan using a novel sumatriptan auto-injector (Alsuma(®) ), and to evaluate the safety, tolerability, and effectiveness of this sumatriptan auto-injector during an acute migraine attack. BACKGROUND: This sumatriptan auto-injector is a ...
Wang Kang - - 2012
Cooperation is the name of the game: The first example of a chiral phthalocyanine dimer with well-defined supramolecular weight and symmetry formed through cooperative multiple π-π interactions among nine pairs of aromatic moieties between two chiral phthalocyaninato zinc molecules has been clarified.
Kimura Toshihiro - - 2012
A simple monomeric tungstate, TBA(2)[WO(4)] (I, TBA = tetra-n-butylammonium), could act as an efficient homogeneous catalyst for chemical fixation of CO(2) with 2-aminobenzonitriles to quinazoline-2,4(1H,3H)-diones. Various kinds of structurally diverse 2-aminobenzonitriles could be converted into the corresponding quinazoline-2,4(1H,3H)-diones in high yields at atmospheric pressure of CO(2). Reactions of inactive 2-amino-4-chlorobenzonitrile ...
Kim Hye Min - - 2012
Wertheim's multi-density formalism for pair-wise additive molecular interaction is extended to handle non-additive contributions and is applied to formulate an equation of state (WEOS) for the Gaussian-Charge Polarizable Model (GCPM) of water, with cluster integrals appearing in the theory calculated via the Mayer sampling Monte Carlo method. At both sub- ...
Dieltjens M - - 2012
PURPOSE: Type D personality, defined as a combination of social inhibition and negative affectivity, has been associated with poor medication adherence and lower adherence to continuous positive airway pressure in patients with sleep-disordered breathing. Up to this date, the association of patient's personality with adherence with a mandibular advancement device ...
Cortelezzi Agustina - - 2012
Our objective was to assess the effect of the physical habitat degradation in three lowland streams of Argentina that are subject to different land uses. To address this matter, we looked into some physical habitat alterations, mainly the water quality and channel changes, the impact on macrophytes' community, and the ...
Kerschgens Isabel P - - 2012
The pharmacologically interesting indole alkaloids (-)-mitragynine, (+)-paynantheine and (+)-speciogynine were synthesised in nine steps from 4-methoxytryptamine by a route featuring (i) an enantioselective thiourea-catalysed Pictet-Spengler reaction, providing the tetrahydro-β-carboline ring and (ii) a Pd-catalysed Tsuji-Trost allylic alkylation, closing the D-ring.
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