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Results 701 - 750 of 2032
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Panazzolo Diogo G - - 2012
ABSTRACT: BACKGROUND: We aimed to evaluate the multivariate association between functional microvascular variables and clinical-laboratorial-anthropometrical measurements. METHODS: Data from 189 female subjects (34.0+/-15.5 years, 30.5+/-7.1 kg/m2), who were non-smokers, non-regular drug users, without a history of diabetes and/or hypertension, were analyzed by principal component analysis (PCA). PCA is a classical ...
Lu Xun - - 2012
MafA is a proto-oncoprotein, and is critical for insulin gene expression in pancreatic β-cells. Maf proteins belong to the AP1 superfamily of basic region-leucine zipper (bZIP) transcription factors. Residues in the basic helix and an ancillary N-terminal domain, the Extended Homology Region (EHR), endow maf proteins with unique DNA binding ...
Darling Katharine Elizabeth Anna - - 2012
OBJECTIVES: Street-based sex workers (SSWs) in Lausanne, Switzerland, are poorly characterised. We set out to quantify potential vulnerability factors in this population and to examine SSW healthcare use and unmet healthcare requirements. METHODS: We conducted a cross-sectional questionnaire-based survey among SSWs working in Lausanne's red light district between 1 February ...
Dmytriyeva Oksana - - 2012
Identification of novel pro-survival factors in the brain is paramount for developing neuroprotective therapies. The multifunctional S100 family proteins have important roles in many human diseases and are also upregulated by brain injury. However, S100 functions in the nervous system remain unclear. Here we show that the S100A4 protein, mostly ...
Lee Ah Young - - 2012
BACKGROUND: Widespread white matter (WM) pathology in preterm children has been proposed. OBJECTIVE: The purpose of this study was to investigate maturational differences of WM between preterm infants with thinning of the corpus callosum and full-term infants. MATERIALS AND METHODS: A total of 18 preterm children and 18 full-term children ...
Stiefel Klaus M - - 2012
This letter discusses temporal order coding and detection in nervous systems. Detection of temporal order in the external world is an adaptive function of nervous systems. In addition, coding based on the temporal order of signals can be used as an internal code. Such temporal order coding is a subset ...
Shirota Hideaki - - 2012
We report here the low-frequency spectra, resulting from the intermolecular/interionic vibrational dynamics, of aqueous mixtures of an ionic liquid, 1-methyl-3-n-octylimidazolium tetrafluoroborate, with the H(2)O mole fractions of 0.2, 0.4, and 0.6 and the neat ionic liquid and H(2)O within the frequency range of 0.1-700 cm(-1) by means of femtosecond Raman-induced ...
Luo Wenping - - 2012
Uterine decidualization, characterized by stromal cell proliferation and differentiation into polyploid decidual cells, is critical to the establishment of prgnancy in mice, although the mechanism underlying this process remains poorly understood. This study is the first to investigate the expression of gamma-amino butyric acid (GABA) and the GABA A-type receptor ...
Jung Sang-Myung - - 2012
The central nervous system (CNS), once injured, rarely recovers original function mainly due to its limited regeneration ability. Astrocytes are cells that play critical roles in neural regeneration. Several biomaterials have been studied to replace and regenerate lost tissues within injured CNS. Seaweeds have extracellular polymeric substances (EPS) with bioactive ...
Hong Oisaeng - - 2012
Background. Noise-induced hearing loss is a significant occupational injury for firefighters exposed to intermittent noise on the job. It is important to educate firefighters about using hearing protection devices whenever they are exposed to loud noise. Computer technology is a relatively new health education approach and can be useful for ...
Jiménez-Ferrer Enrique - - 2012
Recent studies of Hibiscus sabdariffa Linn. have demonstrated that it presents diuretic, natriuretic, and potassium sparing effects. However, the mechanism that induces these effects has not yet been elucidated. The aim of this study was to explore the possible mechanism of action for the diuretic effect of Hibiscus sabdariffa extract and ...
C Lopes Ilanna - - 2012
Temozolomide (TMZ) is an antineoplastic alkylating agent with activity against serious and aggressive types of brain tumours. It has been postulated that TMZ exerts its antitumor activity via its spontaneous degradation at physiological pH. The in vitro evaluation of the interaction of TMZ and its final metabolites, 5-aminoimidazole-4-carboxamide (AIC) and ...
Nielsen Susan B - - 2012
In paediatric practice, mean reference energy requirements for groups are often used to predict individual infant energy requirements. References from the FAO/WHO/United Nations University are based on infants not fed according to the current infant feeding recommendations. The objective of the present study was to measure total energy expenditure (TEE) ...
Faiella Marina - - 2012
A new artificial metalloenzyme, MP3 (MiniPeroxidase 3), designed by combining the excellent structural properties of four-helix bundle protein scaffolds with the activity of natural peroxidases, was synthesised and characterised. This new hemeprotein model was developed by covalently linking the deuteroporphyrin to two peptide chains of different compositions to obtain an asymmetric ...
Miyake Yoshihiro - - 2012
Visible-light-mediated direct sp(3) CH amination of benzocyclic amines via α-aminoalkyl radicals by using photoredox catalysts is described here. The obtained N,N-acetals were also successfully applied for carbon-carbon bond forming reactions with carbon nucleophiles. The procedure is suitable for a late-stage modification of CH bonds to CC bonds.
Liu Xiong X Department of Otolaryngology, Nanfang Hospital, Nanfang Medical University, Guangzhou, Guangdong 510515, P. R. - - 2012
Nasopharyngeal carcinoma(NPC) is a metastatic carcinoma that is highly prevalent in Southeast Asia. Our laboratory has previously demonstrated that the C-terminal 27-kDa polypeptide of human telomerase reverse transcriptase (hTERTC27) inhibits the growth and tumorigenicity of human glioblastoma and melanoma cells. In this study, we investigated the antitumor effect of hTERTC27 ...
Sasaki Takeshi T Department of Medicine/Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. - - 2012
The association of scar on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) with local electrograms on electroanatomic mapping has been investigated. We aimed to quantify these associations to gain insights regarding LGE-CMR image characteristics of tissues and critical sites that support postinfarct ventricular tachycardia (VT). LGE-CMR was performed in 23 ...
Sproviero Daisy - - 2012
Aberrant glycosylation is a common feature of malignant change. Changes in mucin type O-linked glycosylation in breast cancer can result in the expression of truncated core 1-based sialylated glycans rather than the core 2-based glycans observed in normal mammary epithelium cells. This has been shown in part to be due ...
Sinha Ray Suprakas - - 2012
Binary blends of two biodegradable polymers: polylactide (PLA), which has high modulus and strength but is brittle, and poly[(butylene succinate)-co-adipate] (PBSA), which is flexible and tough, were prepared through batch melt mixing. The PLA/PBSA compositions were 100/0; 90/10; 70/30; 60/40; 50/50; 40/60; 30/70; 10/90 and 0/100. Fourier-transform infrared measurements revealed ...
Pringels Sarah - - 2012
ABSTRACT: BACKGROUND: mRNA levels of members of the Vascular Endothelial Growth Factor family (VEGF-A, -B, -C, -D, Placental Growth Factor/PlGF) have been investigated as tissue-based markers of colon cancer. These studies, which used specimens obtained by surgical resection or colonoscopic biopsy, yielded contradictory results. We studied the effect of the ...
Motokawa Masahide M Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan. - - 2013
To investigate the effects of long-term, artificially created, hypofunctional occlusion and its recovery on the morphology of rat molar roots. Eighteen 5-week-old Wistar-strain male rats were randomly divided according to their periodontal conditions into normal, hypofunctional, and recovery groups (n = 6 in each). In the experimental hypofunctional and recovery ...
Schenk Jonas - - 2012
The influence of a humid or dry atmosphere on acoustically levitated ionic liquid droplets was studied by volumetric analysis and vibrational spectroscopy. Imidazolium based ionic liquids with two types of anions, fluorinated (BF4 and PF6) and alkylsulfate anions, were investigated. The amount of absorbed water was correlated with structural differences ...
Nigorikawa Kiyomi - - 2012
Studies with knockout mice have indicated that the only isoform of phosphoinositide 3-kinase (PI3K) functioning in the oxidative burst of mouse neutrophils in response to heterotrimeric guanine nucleotide-binding protein-coupled receptor (GPCR) agonists is a class-IB PI3K, p110γ. In the present study, we observed that the cells from p110γ(-/-) mice gain ...
Pendergraph Samuel A - - 2012
Flexible substrates enable new capabilities in applications ranging from electronics to biomedical devices. To provide a new platform for these applications, we investigate a composite material consisting of rigid fiber fabrics impregnated in soft elastomers, offering the ability to create load bearing, yet flexible substrates. We demonstrate an integrated and ...
Cabral Linda - - 2012
This qualitative study sought to better understand the experiences of deaf and hard of hearing individuals with accessing recovery-oriented mental health services and peer support via a focus group and interviews. Cultural brokers were used to facilitate culturally-sensitive communication with study participants. Findings indicate that access to adequate mental health ...
Birsa Čelič Tadeja - - 2012
Crystal engineering: The synthesis of the known compounds MIL-100(Fe) and MIL-45(Fe) is characterized by spectroscopy. The products are obtained under identical conditions by varying the solvent from pure water to a mixture of water and acetone. The starting solution, the gel, and the final reaction product were characterized by X-ray ...
Pires A F A - - 2012
SUMMARY A 3-year longitudinal study was conducted on a multi-site farrow-to-finish production system. For each of 18 cohorts at three finishing sites, 50 pigs were randomly selected. Faecal samples were collected every 2 weeks for 16 weeks. Salmonella was cultured from 453 (6·6%) of 6836 faecal samples. The pig-level incidence ...
Amoah Vincent - - 2012
We sought to assess the relationships between platelet reactivity at different time points, CYP2C19*2 and ABCB1 status and clinical outcomes in patients with acute coronary syndromes (ACS). Anti-platelet response to clopidogrel was studied prospectively using the VerifyNow (VN) P2Y(12) assay at the time of angiography and at 30 days post ...
Kocyigit Ismail - - 2012
To test the role of platelet activation in the prognosis of nephrotic syndrome (NS), we evaluated the mean platelet volume (MPV) in patients with NS undergoing treatment. In this prospective, multicenter clinical study 156 patients with primary NS under treatment were assigned and followed for one year. Patients were divided ...
Tao Ran - - 2012
Initiated chemical vapor deposition (iCVD) of poly(glycidyl methacrylate) from supersaturated monomer vapor is reported. Rapid film growth rates, up to 600 nm/min, were observed. Films grown from supersaturated monomer exhibited distinct surface undulations. The temporal evolution of surface features during film growth was studied and is explained by monomer condensation ...
Tam Winnie F WF Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, - - 2013
MOZ-TIF2 is a leukemogenic fusion oncoprotein that confers self-renewal capability to hematopoietic progenitor cells and induces acute myelogenous leukemia (AML) with long latency in bone marrow transplantation assays. Here, we report that FLT3-ITD transforms hematopoietic cells in cooperation with MOZ-TIF2 in vitro and in vivo. Coexpression of FLT3-ITD confers growth ...
Daros A R - - 2012
BACKGROUND: Emotion dysregulation represents a core symptom of borderline personality disorder (BPD). Deficits in emotion perception are thought to underlie this clinical feature, although studies examining emotion recognition abilities in BPD have yielded inconsistent findings. Method The results of 10 studies contrasting facial emotion recognition in patients with BPD (n = 266) ...
Baert Jeroen J - - 2012
The chemistry of beer flavor instability remains shrouded in mystery, despite decades of extensive research. It is, however, certain that aldehydes play a crucial role because their concentration increase coincides with the appearance and intensity of "aged flavors". Several pathways give rise to a variety of key flavor-active aldehydes during ...
Sahoo Gokarneswar - - 2012
Pause and play: Dihydrooxazine oxides are stable intermediates that are protonated directly, without the intermediacy of the zwitterions, in organocatalytic Michael additions of aldehydes and nitroalkenes (see scheme, R=alkyl). Protonation of these species explains both the role of the acid co-catalyst in these reactions, and the observed stereochemistry when the ...
Yu Dahua - - 2012
AimMultiple diffusion tensor imaging (DTI) derived indices may help to deduce the pathophysiological type of white matter (WM) changes and provide more specific biomarkers of WM neuropathology in the whole brain of migraine patients without aura (MWoA).MethodsTwenty MWoA and 20 age-, education- and gender-matched healthy volunteers participated in this study. ...
Buckberg Gerald - - 2012
Heart failure (HF) is an emerging epidemic affecting 15 million people in the USA and Europe. HF-related mortality was unchanged between 1995 and 2009, despite a decrease in the incidence of cardiovascular disease. Conventional explanations include an aging population and improved treatment of acute myocardial infarction and HF. An adverse ...
Selby Edward A EA Department of Psychology, Rutgers University, 53 Avenue E., Piscataway, NJ 08854-8040, USA. - - 2013
Suicidal ideation (SI) and thoughts of death are often experienced as fluctuating; therefore a dynamic representation of this highly important indicator of suicide risk is warranted. Theoretical accounts have suggested that affective, behavioral, and interpersonal factors may influence the experience of thoughts of death/SI. This study aimed to examine the ...
Kwong Winghan Jacqueline - - 2012
BACKGROUND:Despite the uncertainty surrounding the safety of switching warfarin formulations, limited data exist on the resource use and costs associated with this switching pattern.OBJECTIVE:To evaluate health care resource use and costs associated with switching warfarin formulations among patients with atrial fibrillation (AF) in a managed care organization.METHODS:Patients diagnosed with AF ...
Hamamoto Kouko - - 2012
A quantitative assay method by LC/ESI-MS/MS for the simultaneous determination of MCP in cattle plasma was developed and validated. The chromatographic separation was carried out using a multimode column (2 mm × 150 mm, 3 μm) with gradient elution (0.05% formic acid/methanol with 0.05% formic acid). MCP and levosulpiride (internal ...
Bouchoucha Yassine Xavier - - 2012
In this study, we have investigated the expression and function of the transcription factor early growth response factor 2 (Egr2)/Krox20 in the developing anterior pituitary. Egr2 is initially expressed in all differentiating hormonal cells types, but its expression is mostly restricted to the somatotroph lineage after birth. Egr2 knockout results ...
Benz Oscar S - - 2012
The formation of CoIIITMPyP(CN)2 at pH 7.4 has been shown to be completely cooperative (H = 2) with an association constant of 2.1 (± 0.2) x 1011. The kinetics were investigated by stopped-flow spectrophotometry and revealed a complicated net reaction exhibiting 4 phases at pH 7.4 under conditions where cyanide ...
McLaurin Emily J - - 2012
Alloyed Zn(1-x-y)Cd(x)Mn(y)Se nanocrystals exhibiting bright intrinsic dual emission attractive for ratiometric optical nanothermometry are reported. Relative to earlier materials with related dual emission, these alloy nanocrystals require shorter syntheses, contain less Cd(2+), and show dual emission that is less sensitive to nanocrystal shape, size, or surfaces.
Cao Mao-Sheng - - 2012
Light-weight nanocomposites filled with carbon nanotubes (CNTs) are developed for their significant potentials in electromagnetic shielding and attenuation for wide applications in electronics, communication devices and specific parts in aircrafts and vehicles. Specifically, the introduction of a second phase into/onto CNTs for achieving CNT-based heterostructures has been widely pursued due ...
Linnenschmidt Meike - - 2012
During echolocation, toothed whales produce ultrasonic clicks at extremely rapid rates and listen for the returning echoes. The auditory brainstem response (ABR) duration was evaluated in terms of latency between single peaks: 5.5 ms (from peak I to VII), 3.4 ms (I-VI), and 1.4 ms (II-IV). In comparison to the killer whale and ...
Xu Su-Yang - - 2012
A topological insulator protected by time-reversal symmetry is realized via spin-orbit interaction-driven band inversion. The topological phase in the Bi(1-x)Sb(x) system is due to an odd number of band inversions. A related spin-orbit system, the Pb(1-x)Sn(x)Te, has long been known to contain an even number of inversions based on band ...
Lei Ming - - 2012
Compared to other cereals, rice has particular strong As accumulation. Therefore, it is very important to understand As uptake and translocation among different genotypes. A field study in Chenzhou city, Hunan province of China, was employed to evaluate the effect of arsenic-contaminated soil on uptake and distribution in 34 genotypes ...
Balakrishnan Balamuralithara - - 2012
The unique properties of nanotechnology have made nanotechnology education and its related subjects increasingly important not only for students but for mankind at large. This particular technology brings educators to work together to prepare and produce competent engineers and scientists for this field. One of the key challenges in nanotechnology ...
Clardy Stacey L - - 2012
Autoimmune and immune-mediated mechanisms are increasingly appreciated in many neurologic diseases. The goal of fellowship training is to develop an understanding of the pathophysiology and treatment of these diseases with a focus on immunology that is not traditionally afforded to most trainees during residency or fellowship. Neuroimmunology is an expanding ...
Chopra Poonam P Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA. - - 2013
Mixed micelles prepared using sodium taurocholate (TA) and egg lecithin (LE) were previously found to be an effective carrier for sustained release of a poorly water-soluble drug in transscleral iontophoretic delivery. The objectives of the present study were to investigate the effects of drug lipophilicity upon micellar carrier solubilization potential ...
Lo Hong-Jay - - 2012
A chiral pool based synthetic strategy that leads from the readily available and inexpensive C(2)-symmetric tartaric acids to the chiral O-isopropylidenebenzooxazole-a convenient precursor to the aminocyclitol core of hygromycin A as well as the chiral γ-disilyloxybutyrolactone-a pivotal intermediate to approach to the furanoside of hygromycin A.
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