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Kollef Marin H - - 2012
ABSTRACT: INTRODUCTION: To compare a 7-day course of doripenem to a 10-day course of imipenem-cilastatin for ventilator-associated pneumonia (VAP) due to Gram-negative bacteria. METHODS: A prospective, double-blinded, randomized trial comparing a fixed 7-day course of doripenem 1 gram as a 4-hour infusion every 8 hours with a fixed 10-day course ...
Stanton Marissa J - - 2013
A major contributor to cancer mortality is recurrence and subsequent metastatic transformation following therapeutic intervention. Therefore, in order to develop new treatment modalities and improve the efficacy of current ones, it is important to understand the molecular mechanisms that promote resistance to therapy in cancer cells. One pathway contributing to ...
Galli E - - 2012
PURPOSE: Congenital hemophilia is a hereditary bleeding disorder that affects 1 in 5,000 males and is characterized by repetitive musculoskeletal bleeding episodes. Selective embolization of the knee and elbow arteries can prevent bleeding episodes. To evaluate the long-term efficacy of these procedures, we assessed the outcomes of 30 procedures performed ...
Wang Ying - - 2012
Multidrug resistance (MDR) is one of the factors in the failure of anticancer chemotherapy. In order to enhance the anticancer effect of P-glycoprotein (P-gp) substrates, inhibition of the P-gp efflux pump on MDR cells is a good tactic. We designed novel multifunctional drug-loaded alpha-tocopheryl polyethylene glycol succinate (TPGS)/poly(lactic-co-glycolic acid) (PLGA) ...
Yagishita Fumitoshi - - 2012
Separated: 3-Hydroxy-3-phenylisoindolin-1-ones have been resolved by dynamic preferential crystallization. The compounds were effectively racemized through ring-opening and ring-closing reactions via achiral intermediates under basic conditions. Crystallization from a toluene solution containing 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) with stirring and evaporation of the solvent gave optically active crystals quantitatively with high ee values.
Kim Bo Hyung - - 2012
A new series of molecular engineered dyes having a carbazole (CA) based bulky donor was synthesized and compared to a previously studied set of dyes having a diphenyl amine (DP) donor for their use in dye sensitized solar cells. In this work, their photophysical, electrochemical, and kinetic properties were measured ...
Laurencin Mathieu - - 2012
de novo cyclic pseudopeptides composed of α-amino and aza-β3-amino acids were designed with the aim to obtain potential new antimicrobial agents. Antimicrobial Cyclic PseudoPeptides (ACPPs) are based on the properties of Antimicrobial Peptides (AMPs), so they are cationic and amphiphilic. Aza-β3-amino acids enhance the in vivo half-life of these compounds ...
Yang Qiong - - 2012
Alterations in the methylation of promoters of cancer-related genes are promising biomarkers for the early detection of disease. Compared with single methylation alteration, assessing combined methylation alterations can provide higher association with specific cancer. Here we use cationic conjugated polymer-based fluorescence resonance energy transfer to quantitatively analyse DNA methylation levels ...
Ju Na Rae NR Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, - - 2013
Breast cancer patients whose tumors achieve a pathological complete response (pCR) with neoadjuvant chemotherapy have a prognosis which is better than that predicted for the stage of their disease. However, within this subgroup of patients, recurrences have been observed. We sought to examine factors associated with recurrence in a population ...
Wang Jin - - 2012
Flexible and highly conductive single-walled carbon nanotube/polycellulose papers (SWCNT/PPs) were developed as current collectors for lithium-ion batteries by a simple and scalable process. The flexible electrodes based on SWCNT/PP conductors consisted of a unique three-dimensional interwoven structure of electrode materials and cellulose fibers with CNTs and exhibited flexibility, good electrochemical ...
Ijspeert Auke Jan - - 2012
Nonlinear dynamical systems have been used in many disciplines to model complex behaviors, including biological motor control, robotics, perception, economics, traffic prediction, and neuroscience. While often the unexpected emergent behavior of nonlinear systems is the focus of investigations, it is of equal importance to create goal-directed behavior (e.g., stable locomotion ...
Pastukhov Alexander - - 2012
In the structure-from-motion paradigm, physical motion on a screen produces the vivid illusion of an object rotating in depth. Here, we show how to dissociate illusory depth and illusory rotation in a structure-from-motion stimulus using a rotationally asymmetric shape and reversals of physical motion. Reversals of physical motion create a ...
Sakata Kenji - - 2012
BACKGROUND: EXAGGERATED NEOINTIMAL HYPERPLASIA IS CONSIDERED AS THE PRIMARY MECHANISM FOR INCREASED RESTENOSIS IN PATIENTS WITH DIABETES MELLITUS (DM) TREATED WITH BARE-METAL STENT. HOWEVER, THE VESSEL RESPONSE IN DM AND NON-DM TREATED WITH DIFFERENT DRUG-ELUTING STENTS (DES) HAS NOT BEEN SYSTEMATICALLY EVALUATED.METHODS AND RESULTS: WE INVESTIGATED 3D INTRAVASCULAR ULTRASOUND (POSTPROCEDURE ...
Heljo Ville P - - 2012
Melibiose monohydrate has shown promise when employed as a pharmaceutical excipient, but its physical properties have not been adequately characterized. Therefore, two different melibiose monohydrate batches were analyzed as received or after storage under different relative humidity (RH) atmospheres. The particle size distributions and specific surface areas of the two ...
Yu Junjing J Chinese Academy of Sciences Key Laboratory of Infection and Immunity, Institute of Biophysics, Beijing 100101, - - 2013
Bone morphogenetic proteins (BMPs) signaling essentially regulates a wide range of biological responses. Although multiple regulators at different layers of the receptor-effectors axis have been identified, the mechanisms of homeostatic BMP signaling remain vague. Herein we demonstrated that myotubularin-related protein 4 (MTMR4), a FYVE domain-containing dual-specificity protein phosphatase (DUSP), preferentially ...
Swillens Abigail - - 2012
In the search for better predictors of cardiovascular events, pulse wave velocity (PWV) has gained considerable interest. We compared three single-location methods to locally estimate PWV based on simultaneous measurements of pressure (P), velocity (U) or arterial diameter (D): the PU, ln(D)U and QA-method. First, the performance of these methods ...
Yang Yanou - - 2012
Certain functional groups/structural motifs are known to generate chemically reactive metabolites that can covalently modify essential cellular macromolecules, and therefore have the potential to disrupt biological function and elicit idiosyncratic adverse drug reactions. In this report, we describe the bioactivation of 5-substituted 2-(alkylthio)-1, 3, 4 thiadiazoles and 2-(alkylthio)-1, 3-benzothiazoles, which ...
Silvestri Catherine C Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, - - 2013
The chemotherapeutic activities of many anticancer and antibacterial drugs arise from their interactions with nucleic acid substrates. Some of these ligands interact with DNA in a way that causes conformational changes or damage to the nucleic acid targets, ultimately altering recognition by key DNA-specific enzymes, interfering with DNA transcription or ...
McMullan Jason T JT Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH 45267-0769, USA. - - 2013
The choice of the optimal benzodiazepine to treat prehospital status epilepticus is unclear. Lorazepam is preferred in the emergency department, but concerns about nonrefrigerated storage limits emergency medical services (EMS) use. Midazolam is increasingly popular, but its heat stability is undocumented. This study evaluated temperature-dependent degradation of lorazepam and midazolam ...
Duan Hongliang - - 2012
4-Phenoxy-nicotinamide and 4-phenoxy-pyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists are reported. Several 4-phenoxy-nicotinamide derivatives were found to activate human and mouse TGR5 (hTGR5 and mTGR5) with EC50 values in the low nanomolar range. Compound 23g, with an EC50 value of 0.72 nM on hTGR5 and 6.2 nM on ...
Luckanagul Jittima Amie - - 2012
In regenerative medicine, synthetic extracellular matrix is crucial for supporting stem cells during its differentiation process to integrate into surrounding tissues. Hydrogels are used extensively in biomaterials as synthetic matrices to support the cells. However, in order to mimic the biological niche of a functional tissue, various chemical functionalities are ...
Rognoni Lorenz - - 2012
Mechanical forces are important signals for cell response and development, but detailed molecular mechanisms of force sensing are largely unexplored. The cytoskeletal protein filamin is a key connecting element between the cytoskeleton and transmembrane complexes such as integrins or the von Willebrand receptor glycoprotein Ib. Here, we show using single-molecule ...
Zhang Chunchao C Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, - - 2013
Nuclear DNA in eukaryotic cells is assembled into the hierarchical chromatin structure via a process that is dynamically affected by the combinatorial set of post-translational modifications (PTMs) of histones in a dynamic manner responsive to physiological and environmental changes. The precise quantification of these complex modifications is challenging. Here we ...
Yu Wei W School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, P. R. - - 2013
Smoking is the primary cause of lung cancer and is linked to 85% of lung cancer cases. However, how lung cancer develops in patients with smoking history remains unclear. Systems approaches that combine human protein-protein interaction (PPI) networks and gene expression data are superior to traditional methods. We performed these ...
Schlegel Thomas - - 2012
Of the many signals used by honey bees during the process of swarming, two of them-the stop signal and the worker piping signal-are not easily distinguished for both are mechano-acoustic signals produced by scout bees who press their bodies against other bees while vibrating their wing muscles. To clarify the ...
Goh Wei Jiang - - 2012
Biofuels are fast advancing as a new research area to provide alternative sources of sustainable and clean energy. Recent advances in nanotechnology have sought to improve the efficiency of biofuel production, enhancing energy security. In this study, we have incorporated iron oxide nanoparticles into Single-Wall Carbon Nanotubes (SWCNTs) to produce ...
Houben Anna J S AJ Division of Cell Biology, The Netherlands Cancer Institute, 1066CX Amsterdam, The - - 2013
Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA), playing a key role in diverse physiological and pathological processes. ATX exists in distinct splice variants, but isoform-specific functions remain elusive. Here we characterize the ATXα isoform, which differs from the canonical form (ATXβ) in ...
Chen Yuanli Y State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, - - 2012
IL-5 stimulates production of T15/EO6 IgM antibodies that can block the uptake of oxidized low density lipoprotein by macrophages, whereas a deficiency in macrophage IL-5 expression accelerates development of atherosclerosis. Liver X receptors (LXRs) are ligand-activated transcription factors that can induce macrophage ABCA1 expression and cholesterol efflux, thereby inhibiting the ...
Voronina Ekaterina - - 2012
P granules are conserved cytoplasmic organelles, similar to nuage, that are present in Caenorhabditis elegans germ cells. Based on the prevailing sterility phenotype of the component mutants, P granules have been seen as regulators of germ cell development and function. Yet, specific germline defects resulting from P-granule failure vary, depending ...
Patkar Chinmay - - 2013
Dengue hemorrhagic fever is characterized by a unique vascular leakage syndrome. The mechanisms of endothelial barrier dysfunction in dengue hemorrhagic fever are not well understood. We examined the modulation of endothelial barrier function in dengue virus type 2 (DENV2) infections using primary human umbilical vein endothelial cells. We demonstrated that ...
Wang Xiaoying - - 2012
In this study, an attempt was made to prepare novel D-glucosamine hydrochloride-rectorite (DGH-REC) nanocomposites with improved antioxidant and anti-ultraviolet activity via the solution-intercalation method. The structure and morphology of DGH-REC nanocomposites were characterized by XRD, TEM, (13)C CP/MAS NMR, FT-IR, XPS and SEM. The results showed that the interlayer distance ...
Lobayan Rosana M - - 2012
The TRA (3-[2-aminoethyl]indole) is an important neurotransmitter with a close structural and chemical similarity to the neurotransmitter serotonin (5-hydroxytryptamine), and to melatonin (5-methoxy-N-acetyltryptamine), which plays a key role in daily human behavior. Moreover, TRA, and other indolic compounds are very efficient antioxidants. In this work the conformational space of TRA ...
Pianezzola E - - 2012
Arion vulgaris Moquin-Tandon 1855 is one of the most important invasive species in Europe, affecting both biodiversity and agriculture. The species is spreading in many parts of Europe, inflicting severe damage to horticultural plants and cultivated crops partly due to a lack of satisfactory and effective management solutions. Molluscicides have ...
Depew Zachary S - - 2012
Objectively measured severe physical inactivity (SPI) has been reported as the strongest independent predictor of mortality in patients with chronic obstructive pulmonary disease (COPD). Activity monitoring is not feasible in routine clinical practice; therefore, we set out to determine the utility of simple clinical measures for predicting SPI in patients ...
Cheng Ting-Jen R - - 2012
The wizard of OS (resistance): The binding difference of neuraminidase inhibitors (zanamivir versus oseltamivir (OS)) was used to establish an assay to identify the influenza subtypes that are resistant to OS but still sensitive to zanamivir. This assay used a zanamivir-biotin conjugate to determine the OS susceptibility of a wide ...
Landy Stephen H - - 2012
OBJECTIVE: To assess the ability of patients, during an acute migraine attack, to successfully self-inject a single dose of sumatriptan using a novel sumatriptan auto-injector (Alsuma(®) ), and to evaluate the safety, tolerability, and effectiveness of this sumatriptan auto-injector during an acute migraine attack. BACKGROUND: This sumatriptan auto-injector is a ...
Wang Kang - - 2012
Cooperation is the name of the game: The first example of a chiral phthalocyanine dimer with well-defined supramolecular weight and symmetry formed through cooperative multiple π-π interactions among nine pairs of aromatic moieties between two chiral phthalocyaninato zinc molecules has been clarified.
Kimura Toshihiro - - 2012
A simple monomeric tungstate, TBA(2)[WO(4)] (I, TBA = tetra-n-butylammonium), could act as an efficient homogeneous catalyst for chemical fixation of CO(2) with 2-aminobenzonitriles to quinazoline-2,4(1H,3H)-diones. Various kinds of structurally diverse 2-aminobenzonitriles could be converted into the corresponding quinazoline-2,4(1H,3H)-diones in high yields at atmospheric pressure of CO(2). Reactions of inactive 2-amino-4-chlorobenzonitrile ...
Kim Hye Min - - 2012
Wertheim's multi-density formalism for pair-wise additive molecular interaction is extended to handle non-additive contributions and is applied to formulate an equation of state (WEOS) for the Gaussian-Charge Polarizable Model (GCPM) of water, with cluster integrals appearing in the theory calculated via the Mayer sampling Monte Carlo method. At both sub- ...
Dieltjens M - - 2012
PURPOSE: Type D personality, defined as a combination of social inhibition and negative affectivity, has been associated with poor medication adherence and lower adherence to continuous positive airway pressure in patients with sleep-disordered breathing. Up to this date, the association of patient's personality with adherence with a mandibular advancement device ...
Cortelezzi Agustina - - 2012
Our objective was to assess the effect of the physical habitat degradation in three lowland streams of Argentina that are subject to different land uses. To address this matter, we looked into some physical habitat alterations, mainly the water quality and channel changes, the impact on macrophytes' community, and the ...
Nittala Muneeswar Gupta - - 2012
PURPOSE: To evaluate the accuracy and reproducibility of drusen quantification by an automated drusen segmentation algorithm in spectral domain optical coherence tomography (SD-OCT) images of eyes with non-neovascular age-related macular degeneration (AMD). METHODS: Drusen segmentation was performed using both a commercial automated algorithm (Cirrus OCT RPE analysis tool) and manual ...
Farcau Cosmin - - 2012
SERS substrates fabricated from chemically synthesized nanoparticles (NPs) offer a distinct advantage of localizing and enhancing the electromagnetic fields by facile tuning of NP size, shape and interparticle distances. In this report, two-dimensional arrays of micrometre-sized clusters of gold nanoparticles protected by (i) sodium citrate and (ii) tris(2,4-dimethyl-5-sulfonatophenyl)phosphine (TDSP) ligands ...
Dutta Pranabesh - - 2012
A new D-A conjugated organic small molecule, BDT(TBT)2 comprised of benzo[1,2-b:4,5-b']dithiophene and 2,1,3-benzothiadiazole units was designed and synthesized. The small molecule BDT(TBT)2 in its thin film showed absorption band in the range of 300-700 nm with absorption maxima at 650 nm and an optical band gap of 1.90 eV. As ...
Enriquez-Flores C I - - 2012
A new resonance-tracking (RT) method using fast frequency sweeping excitation was developed for quantitative scanning probe microscopy (SPM) imaging. This method allows quantitative imaging of elastic properties and ferroelectrical domains with nanoscale resolution at high data acquisition rates. It consists of a commercial AFM system combined with a high-frequency lock-in ...
Moniz Sónia - - 2012
Cystic fibrosis (CF), a major life-limiting genetic disease leading to severe respiratory symptoms, is caused by mutations in CF transmembrane conductance regulator (CFTR), a chloride (Cl-) channel expressed at the apical membrane of epithelial cells. Absence of functional CFTR from the surface of respiratory cells reduces mucociliary clearance, promoting airways ...
Barthel Steven R SR Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, - - 2013
Advanced prostate cancer commonly metastasizes to bone, but transit of malignant cells across the bone marrow endothelium (BMEC) remains a poorly understood step in metastasis. Prostate cancer cells roll on E-selectin(+) BMEC through E-selectin ligand-binding interactions under shear flow, and prostate cancer cells exhibit firm adhesion to BMEC via β1, ...
Fairey Adrian S - - 2012
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Open radical nephroureterectomy (ORNU) with excision of the ipsilateral bladder cuff is a standard treatment for upper tract urothelial carcinoma (UTUC). However, over the past decade laparoscopic RNU (LRNU) has emerged as a minimally invasive surgical alternative. Data comparing ...
Rymer Marilyn M - - 2012
BACKGROUND AND PURPOSE: Compare access and outcomes in a tertiary care community hospital (Saint Luke's Neuroscience Institute) and its stroke network to hospitals in 3 national databases. METHODS: Retrospective analysis of ischemic stroke patients (2005, 2007, 2010) in Saint Luke's (n=1576), Get With The Guidelines-Stroke (n=423 809), Premier (n=91 598), ...
Holubova Monika - - 2012
Establishment of new animal models using selected cell lines with different behaviour is very important for cancer investigations. In this study, we describe three morphologically distinct rat sarcoma clones-C4, C7 and D6-isolated from the R5-28 cell line. Cells of all clones expressed vimentin, fibronectin, laminin, collagen IV and matrix metalloproteinases ...
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