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Results 601 - 650 of 2032
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Jiménez-Durán Karina - - 2013
In Solanaceae, the self-incompatibility S-RNase and S-locus F-box interactions define self-pollen recognition and rejection in an S-specific manner. This interaction triggers a cascade of events involving other gene products unlinked to the S-locus that are crucial to the self-incompatibility response. To date, two essential pistil-modifier genes, 120K and High Top-Band ...
Kirchhoff Chlodwig - - 2012
ABSTRACT: BACKGROUND: Age-dependent trabecular changes of the humeral head might weaken the fixation of suture anchors used for rotator cuff (RC) repair. This might lead to suture anchor loosening and thus compromise the integrity of the repair. The aim of this study was to analyze whether the trabecular microstructure within ...
Wijnen Petal A - - 2012
BACKGROUND: Fibrosing interstitial pneumonias (IPs) include idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP). It has been suggested that oxidative damage plays a role in the pathophysiology of idiopathic interstitial pneumonias. Diffuse alveolar hemorrhage (DAH) can cause oxidative stress. Accordingly, we hypothesized that episodes of DAH might trigger fibrosing ...
Kulkarni M A - - 2012
SUMMARY Encephalitis is a clinical syndrome often associated with infectious agents. This study describes the epidemiology and disease burden associated with encephalitis in Canada and explores possible associations with arboviral causes. Encephalitis-associated hospitalizations, 1994-2008, were analysed according to aetiological category (based on ICD-9/ICD-10 codes) and other factors using multivariate logistic ...
Wang Rui - - 2012
PURPOSEThe RET fusion gene has been recently described in a subset of non-small-cell lung cancers (NSCLCs). Because we have limited knowledge about these tumors, this study was aimed at determining the clinicopathologic characteristics of patients with NSCLC harboring the RET fusion gene. PATIENTS AND METHODSWe examined the RET fusion gene ...
Gerrard Mary M Sheffield Children's Hospital, Sheffield, United - - 2013
Mediastinal large B-cell lymphoma (MLBL) represents 2% of mature B-cell non-Hodgkin lymphoma in patients ≤ 18 years of age. We analyzed data from childhood and adolescent patients with stage III MLBL (n = 42) and non-MLBL DLBCL (n = 69) treated with Group B therapy in the French-American-British/Lymphome Malins de ...
He Zuoli - - 2012
Anatase type nitrogen-fluorine (N-F) co-doped TiO2 nanobelts were successfully prepared by a solvothermal method, which amorphous titania microspheres were used as the precursors. The as-prepared TiO2 nanobelts are composed of thin narrow nanobelts, and it is noted that there are large amount of wormhole-like mesopores on these narrow nanobelts. Photocatalytic ...
Huang Xi - - 2012
As sessile organisms, higher plants have evolved the capacity to sense and interpret diverse light signals to modulate their development. In Arabidopsis thaliana, low-intensity and long-wavelength UV-B light is perceived as an informational signal to mediate UV-B-induced photomorphogenesis. Here, we report that the multifunctional E3 ubiquitin ligase, CONSTITUTIVE PHOTOMORPHOGENESIS1 (COP1), ...
Roberts Kathryn - - 2012
Rheumatic heart disease (RHD) is a leading cause of cardiac disease among children in developing nations, and in indigenous populations of some industrialized countries. In endemic areas, RHD has long been a target of screening programmes that, historically, have relied on cardiac auscultation. The evolution of portable echocardiographic equipment has ...
Jung Kyung-Ho - - 2012
In this study, we investigated the effects of hydrazinonicotinamide (HYNIC)-a bifunctional crosslinker widely used to (99m)Tc radiolabel protein and nanoparticles for imaging studies-on quantum dot opsonization, macrophage engulfment and in vivo kinetics. In streptavidin-coated quantum dots (SA-QDots), conjugation with HYNIC increased the net negative charge without affecting the zeta potential. ...
Liu Hongyan - - 2012
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), as an anticancer protein with tumor-selective apoptotic activity, has been examined for use in clinical application. Melittin, an antibacterial peptide isolated from the bee Apis mellifera, has shown strong cytotoxicity to both tumor and normal cells. To ameliorate the cytotoxicity of melittin on cells ...
Chikazawa Seishiro - - 2012
We established a homologous sandwich enzyme-linked immunosorbent assay (ELISA) to measure serum levels of canine ferritin. Our assay uses a rabbit anti-canine heart ferritin polyclonal antibody, and canine heart ferritin as a standard. Serum ferritin concentration in healthy dogs (n=163) was 789 ± 284 ng/ml (mean ± standard deviation), a ...
Tanabe Seizan - - 2012
ABSTRACT: INTRODUCTION: Conventional monophasic defibrillators for out-of-hospital cardiac arrest patients have been replaced with biphasic defibrillators. However, the advantage of biphasic over monophasic defibrillation for paediatric out-of-hospital cardiac arrest patients remains unknown. This study aimed to compare the survival outcomes of paediatric out-of-hospital cardiac arrest patients who underwent monophasic defibrillation ...
Yamamoto Norifumi - - 2012
A mixture of ferrous ions and hydrogen peroxide, known as Fenton's reagent, is an effective oxidant and has been widely used in various industrial applications; however, there is still controversy about what the oxidizing agents are and how they are produced. In this study, we have determined minimum free-energy paths ...
Cooper Itzik I Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel. - - 2012
Most chemotherapeutic agents are blood-brain barrier (BBB) impermeants. HIV-1-derived TAT protein variants contain a transmembrane domain, which may enable them to cross the BBB and reach the brain. Here we synthesized CAYGRKKRRQRRR, a peptide containing a cysteine moiety attached to the N terminus of the transmembrane domain (C-TAT peptide), and ...
Huang Wenjuan - - 2012
UDP-galactopyranose mutase (UGM) is a key flavoenzyme involved in cell wall biosynthesis of a variety of pathogenic bacteria and hence, integral to their survival. It catalyzes the inter- conversion of UDP-galactopyranose (UDP-Galp) and UDP-galactofuranose (UDP-Galf); inter- conversion of the galactose moieties 6 and 5-membered ring forms. We have synergistically applied ...
Goldoni Andrea - - 2012
Here it is demonstrated, using high-resolution x-ray spectroscopy and density functional theory calculations, that 2H-tetraphenyl-porphyrins metalate at room temperature by incorporating a surface metal atom when a (sub)monolayer is deposited on 3d magnetic substrates, like Fe(110) and Ni(111). The calculations demonstrate that the redox metalation reaction would be exothermic when ...
Hasnain Ghulam - - 2013
Riboflavin (vitamin B₂) is the precursor of the flavin coenzymes flavin mononucleotide and flavin adenine dinucleotide. In Escherichia coli and other bacteria, sequential deamination and reduction steps in riboflavin biosynthesis are catalyzed by RibD, a bifunctional protein with distinct pyrimidine deaminase and reductase domains. Plants have two diverged RibD homologs, ...
Lv Tian-Shi - - 2012
We report for the first time an extremely rare anomalous origin of the superior left pulmonary artery in a 60 year-old man. Although it was occult in clinical indications, such a malformation still ought to be considered, especially during endovascular procedures.
Nevo Yoram - - 2012
CD59 deficiency is a common finding in red and white blood cells in patients with chronic hemolysis suffering from paroxysmal nocturnal hemoglobinuria (PNH) where acquired mutation in the PIGA gene leads to membrane loss of GPI-anchored membrane proteins, including CD59. The current study objective was the elucidation of the molecular ...
Babich Lara - - 2012
Herein, we report a new flow process with immobilized enzymes to synthesize complex chiral carbohydrate analogues from achiral inexpensive building blocks in a three-step cascade reaction. The first reactor contained immobilized acid phosphatase, which phosphorylated dihydroxyacetone to dihydroxyacetone phosphate using pyrophosphate as the phosphate donor. The second flow reactor contained ...
Lindkvist Björn - - 2012
PURPOSE: Little is known about the association between the metabolic syndrome (MetS) and the risk of gastric adenocarcinoma. The aim of this study was to investigate whether metabolic risk factors, together or combined, were associated with the risk of gastric adenocarcinoma. METHODS: The Metabolic Syndrome and Cancer Project (Me-Can) is ...
Wang Jianpu - - 2012
Spintronics based on organic semiconductor materials is attractive because of its rich fundamental physics and potential for device applications. Manipulating spins is obviously important for spintronics, and is usually achieved by using magnetic electrodes. Here we show a new approach where spin populations can be controlled primarily by energetics rather ...
Inano Sachiko - - 2012
PURPOSE: To investigate age-related differences, gender differences, and age-by-gender interactions on the volumes of 18 neuroanatomical structures, with a large sample at a single institution. MATERIALS AND METHODS: A total of 861 normal subjects (mean age = 56.1 ± 9.8 years, age range = 24.0-84.8 years) were included in this ...
Chuang Chun-Ju - - 2012
A molecular cage based [2]rotaxane is reported in which the linear thread component can be elongated and contracted in a stepwise manner, mimicking a two-stage retractable cable that can be operated in both push-button (free-selection) and rotary (continuous-change) modes, depending on the choice of reagents.
Kim Hoe Joon - - 2012
We report a wear-resistant ultrananocrystalline (UNCD) diamond tip integrated onto a heated atomic force microscope (AFM) cantilever and UNCD tips integrated into arrays of heated AFM cantilevers. The UNCD tips are batch-fabricated and have apex radii of approximately 10 nm and heights up to 7 μm. The solid-state heater can reach temperatures ...
Jagadeesan Jagajeevan - - 2012
ABSTRACT: BACKGROUND: Most soft-tissue tumors are clinically palpable; however, some can be impalpable to clinical examination making it difficult to plan surgical management. METHODS: We present a simple method of perioperative tumor localization using a portable ultrasonography machine. RESULTS: We used the technique for seven cases, on each occasion identifying ...
Redova Martina - - 2012
Renal cell carcinoma (RCC) is the most common neoplasm of adult kidney accounting for about 3 % of adult malignancies. MicroRNAs (miRNAs) are a class of naturally occurring, short non-coding RNAs that regulate gene expression at the post-transcriptional level. We determined global miRNA expression profiles of RCC and parallel renal parenchyma ...
Lyons N A - - 2012
SUMMARY A randomized control trial on verocytotoxigenic Escherichia coli (VTEC)-infected farms found evidence that: (1) keeping animals in the same group; (2) maintaining dry bedding; (3) preventing direct contact with neighbouring cattle; and (4) maintaining a closed herd, were associated with a reduced risk of infection in youngstock aged 3-18 ...
Schlattner Uwe U From the Laboratory of Fundamental and Applied Bioenergetics and Federative Research Structure Environmental and Systems Biology, University Joseph Fourier, 38041 Grenoble Cedex 9, - - 2013
The nucleoside diphosphate kinase Nm23-H4/NDPK-D forms symmetrical hexameric complexes in the mitochondrial intermembrane space with phosphotransfer activity using mitochondrial ATP to regenerate nucleoside triphosphates. We demonstrate the complex formation between Nm23-H4 and mitochondrial GTPase OPA1 in rat liver, suggesting its involvement in local and direct GTP delivery. Similar to OPA1, ...
Tang Gui-Hua - - 2012
Two new degraded diterpenoids, trigohowilols A (1) and B (2), four new heterodimers, trigohowilols C-F (3-6), one new homodimer, trigohowilol G (7), and three known degraded diterpenoids (8-10) were isolated from the methanol extract of the stems of Trigonostemon howii. Compounds 1-7 were evaluated for their cytotoxic activity against five ...
Maeda Tadashi - - 2012
We aimed to elucidate the current epidemiological features of outpatient skin and soft tissue infection (SSTI)-associated methicillin-resistant Staphylococcus aureus (MRSA) in Japan. Altogether, we evaluated the performance of a phage-open reading frame typing (POT) kit for genotyping these MRSA strains. We collected 57 MRSA strains from all outpatients with SSTIs ...
Migliaccio Americo A AA Balance and Vision Laboratory, Neuroscience Research Australia, Cnr Barker Street & Easy Street, Randwick, NSW 2031, Australia. - - 2013
Vergence is one of several viewing contexts that require an increase in the angular vestibular-ocular reflex (aVOR) response. A previous monkey study found that the vergence-mediated gain (eye/head velocity) increase of the aVOR was attenuated by 64 % when anodic currents, which preferentially lower the activity of irregularly firing vestibular afferents, ...
Mantarro Stefania - - 2012
ABSTRACT: BACKGROUND: An increased risk of venous thromboembolism has been reported in patients treated with non-steroidal anti-inflammatory drugs (NSAIDs). We describe a case of acute portal vein thrombosis (PVT) in a hepatitis C virus (HCV)-positive elderly patient following administration of indomethacin. CASE PRESENTATION: A 79-year-old HCV-positive man was hospitalized for ...
de Leon Arnie R - - 2012
Substitution of a nucleobase pair with a pair of 1,2-hydroxypyridinone (1,2-HOPO) ligands in the center of a 10-base-pair peptide nucleic acid (PNA) duplex provides a strong binding site for Eu(III) as evidenced by UV thermal melting curves, UV titrations, and luminescence spectroscopy. Eu(III) excitation spectra and luminescence lifetime data are ...
O'Connor Casey - - 2012
Ras is a small monomeric GTPase acting as molecular switch in multiple cellular processes. The N-terminal G domain of Ras binds GTP or GDP accompanied by a magnesium ion, which is strictly required for GTPase activity and performs a structural role. Another ion-binding site on the opposite face of the ...
Szymanski Benjamin R BR Department of Chronic Disease Epidemiology, Yale School of Public Heath, New Haven, CT 06520-8034, USA. - - 2013
Primary Care-Mental Health Integration (PC-MHI) may improve mental health services access and continuity of care. To assess whether receipt of integrated PC-MHI services on the date of an initial positive depression screen influences receipt of depression treatment among primary care (PC) patients in the Veterans Health Administration. Retrospective cohort study. ...
Cho Kyunghyun - - 2012
Restricted Boltzmann machines (RBMs) are often used as building blocks in greedy learning of deep networks. However, training this simple model can be laborious. Traditional learning algorithms often converge only with the right choice of metaparameters that specify, for example, learning rate scheduling and the scale of the initial weights. ...
Erovic Boban M - - 2012
Unlike papillary thyroid carcinoma, medullary thyroid carcinoma is insensitive to adjuvant treatment with radioactive iodine. The clinical management of patients with advanced or metastatic disease remains challenging since no effective systemic adjuvant therapy is available. We aimed to identify markers of aggressive disease and novel drugable protein targets that would ...
Benoit Marie E ME Department of Molecular Biology and Biochemistry, of California at Irvine, Irvine, California 92697, - - 2013
Complement protein C1q is induced in the brain in response to a variety of neuronal injuries, including Alzheimer disease (AD), and blocks fibrillar amyloid-β (fAβ) neurotoxicity in vitro. Here, we show that C1q protects immature and mature primary neurons against fAβ toxicity, and we report for the first time that ...
Romero-Vivas Claudia M E CM Grupo de Investigaciones en Enfermedades Tropicales, Departamento de Medicina, División Ciencias de la Salud, Universidad del Norte, Barranquilla, Colombia. - - 2013
Samples were collected from 128 symptomatic humans, 83 dogs, 49 mice, and 20 rats (Rattus rattus: 16; Rattus norvegicus: 4) in neighborhoods where human leptospirosis have been reported within the principal sea-port city of Colombia. Seroprevalences were assessed against 19 pathogenic, 1 intermediate pathogenic, and 1 saprophytic Leptospira serogroups. Pathogenic ...
Wang Qing - - 2012
Chemical functionalization of the boron nitride nanotube (BNNT) allows a wider flexibility in engineering its electronic and magnetic properties as well as chemical reactivity, thus making it have potential applications in many fields. In the present work, the encapsulation of 13 different Pd(3)M (M = Sc, Ti, V, Cr, Mn, Fe, Co, ...
Shemiakina I I - - 2012
Multicolour labelling with fluorescent proteins is frequently used to differentially highlight specific structures in living systems. Labelling with fusion proteins is particularly demanding and is still problematic with the currently available palette of fluorescent proteins that emit in the red range due to unsuitable subcellular localization, protein-induced toxicity and low ...
Warner Dennis R DR Birth Defects Center, University of Louisville, 501 South Preston Street, Suite 350, Louisville, KY 40202, - - 2013
Loss of Prdm16 expression in the mouse leads to a complete cleft of the secondary palate. We have now determined changes in gene expression in the secondary palates of Prdm16(-/-) fetuses in an attempt to reveal the mechanism(s) leading to the failure of palate closure in these mice. Defined pathway-based ...
Dromparis Peter - - 2012
BACKGROUND: Evidence suggestive of endoplasmic reticulum (ER) stress in the pulmonary arteries (PA) of patients with pulmonary arterial hypertension (PAH) has been described for decades but has never been therapeutically targeted. ER stress is a feature of many conditions associated with PAH like hypoxia, inflammation or loss-of-function mutations. ER stress ...
Brown Blakely - - 2012
PurposeThe purpose of this study was to develop a lifestyle change program for Native American youth by modifying the Diabetes Prevention Program (DPP) and assess implementation indicators and short term behavioral and physiological outcomes of the intervention among a small pilot sample.MethodsCommunity members and project staff modified the original DPP ...
Aboud Omran Abu - - 2012
BACKGROUND:Metabolomics, the study of all metabolites produced in the body, which often includes flora and drug metabolites, is the omics approach that can be considered most closely related to a patient's phenotype. Metabolomics has a great and largely untapped potential in the field of oncology, and the analysis of the ...
Gao Yuanpeng - - 2012
Layered protonated titanate nanosheets (LPTNs) loaded with silver nanoparticles are prepared by a simple one-pot hydrothermal route in silver-ammonia solution. The as-synthesized Ag-loaded LPTNs possess large specific surface area. The Ag nanoparticles are highly dispersed on the surface of the LPTNs. They have negligible effects on the crystal structure, crystallinity, ...
Blancafort Pilar P School of Anatomy, Physiology, and Human Biology, M309, the University of Western Australia, 35 Stirling Highway, Crawley, 6009, WA, Australia. - - 2013
The epigenomic era has revealed a well-connected network of molecular processes that shape the chromatin landscape. These processes comprise abnormal methylomes, transcriptosomes, genome-wide histone post-transcriptional modifications patterns, histone variants, and noncoding RNAs. The mapping of these processes in large scale by chromatin immunoprecipitation sequencing and other methodologies in both cancer ...
Min A-K - - 2012
AIMS/HYPOTHESIS: Fenofibrate is a drug used to treat hyperlipidaemia that works by inhibiting hepatic triacylglycerol synthesis. Sterol regulatory element binding protein-1c (SREBP-1c) is a major regulator of the expression of genes involved in hepatic triacylglycerol synthesis. In addition, endoplasmic reticulum (ER)-bound transcription factor families are involved in the control of ...
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