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Results 601 - 650 of 2028
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Bhatt Surya P - - 2012
Pursed lips breathing (PLB) is used by a proportion of patients with chronic obstructive pulmonary disease (COPD) to alleviate dyspnea. It is also commonly used in pulmonary rehabilitation. Data to support its use in patients who do not spontaneously adopt PLB are limited. We performed this study to assess the ...
Egbunike Veronica - - 2012
PurposeThe purpose of the research was to investigate the impact of point-of-care (POC) A1C testing among patients with type 2 diabetes in a primary care setting.MethodsThis study used a pretest-posttest design with data from patient charts matched for age, sex, race, body mass index, insurance status, and the number of ...
Wu Jun - - 2012
The draft genome of pear (Pyrus bretschneideri) using a combination of BAC-by-BAC and next generation sequencing is reported. A 512.0 Mb sequence corresponding to 97.1% of the estimated genome size of this highly heterozygous species is assembled with 194x coverage. High-density genetic maps comprising of 2,005 SNP markers anchored 75.5% ...
Kim Seon Sook - - 2012
Regulator of calcineurin 1 (RCAN1) is located on the Down syndrome critical region (DSCR) locus in human chromosome 21. In this study, we investigated the functional role of RCAN1 in the reactive oxygen species (ROS)-mediated neuronal death signaling. We found that RCAN1 was able to protect the cells from H(2) ...
Zhang Yi - - 2012
Penicillium sp. MA-37, which was obtained from the rhizospheric soil of the mangrove plant Bruguiera gymnorrhiza, exhibited different chemical profiles in static and shaken fermentation modes. Three new meroterpenoid derivatives, 4,25-dehydrominiolutelide B (1), 4,25-dehydro-22-deoxyminiolutelide B (2), and isominiolutelide A (3), together with three known ones were characterized from its static ...
Bae Sun Ju - - 2012
A spheroidal transgene-networked gel matrix was designed as a synthetic nucleus system. It was spherodically manufactured using both advanced lithography and DNA nanotechnology. Stable Aqueorea coerulescens green fluorescent protein (AcGFP) encoding gene cross-networks have been optimized in various parameters; the number of G-net-gel spheroids, the concentration of a AcGFP plasmid ...
Patel Manali I - - 2012
BACKGROUND: The gastric cancer AJCC/UICC staging system recently underwent significant revisions, but studies on Asian patients have reported a lack of adequate discrimination between various consecutive stages. We sought to validate the new system on a U.S. population database. METHODS: California Cancer Registry data linked to the Office of Statewide ...
Wang Haihua - - 2012
Au@Pd core-shell nanodendrites were synthesized by reducing H(2)PdCl(4) with ascorbic acid onto the surface of Au polyhedra at room temperature. The Au@Pd core-shell nanodendrites consisting of a Au core and nanoporous Pd shell, exhibited plasmonic properties and higher catalytic activity in comparison with Au@Pd core-shell nanocubes.
Juel Helene B - - 2012
PURPOSE: To investigate the effects of T cell-derived cytokines on gene and protein expression of chemokines in a human RPE cell line (ARPE-19). METHODS: We used an in vitro co-culture system in which the RPE and CD3/CD28-activated T cells were separated by a membrane. RPE cell expression of chemokine genes ...
Lee Yonggu - - 2012
ABSTRACT: BACKGROUND: Type VI dual left anterior descending artery (LAD) is a rare coronary anomaly, the first case of which has recently been described. This is the first report of type VI dual LAD anomaly in which the patient presented with non-ST-segment elevation myocardial infarction and percutaneous coronary intervention was ...
Cawello Willi - - 2012
Purpose:  To test for bioequivalence of 200 mg lacosamide oral tablet and syrup formulations. Additional objectives were to compare the pharmacokinetic profile of lacosamide in saliva and plasma, and to evaluate its tolerability. Methods:  This open-label, randomized, two-way crossover trial was conducted in 16 healthy Caucasian male participants in Germany. The ...
Rodríguez-Perálvarez Manuel - - 2012
Selected patients with hepatocellular carcinoma are candidates to receive potentially curative treatments, such as hepatic resection or liver transplantation, but nevertheless there is a high risk of tumor recurrence. Microvascular invasion is a histological feature of hepatocellular carcinoma related to aggressive biological behavior. We systematically reviewed 20 observational studies that ...
Yip Vivien Cherng-Hui - - 2012
Purpose To determine the relationships of puberty and growth spurts with peak spherical equivalent (SE) or axial length (AL) velocity in Singapore school children. Methods In the Singapore Cohort study Of the Risk factors for Myopia of 1779 school children, the longitudinal refractive and pubertal status of 892 boys and ...
Jia Lingyun - - 2012
Two new compounds (triterpenoid saponin and heterocyclic compound), 2α,3β, 19α,23,30-pentahydroxyurs-12-en-28-oic acid-28-O-β-d-glucopyranosyl ester (1) and N-hydroxyl-hexahydroazepin-2,4-diones (2), with 11 known compounds, picein (3), (7S,8R)-dihydrodehydrodiconiferyl alcohol-9'-O-β-d-glucopyranoside (4), (+)-1-hydroxy-2-epipinoresinol-1-β-d-glucoside (5), (+)-1-hydroxypinoresinol-1-β-d-glucoside (6), (+)-1-hydroxypinoresinol-4'-β-d-glucoside (7), schaftside (6-C-β-d-glucopyranosyl-8-C-α-l-arabinosyl apigenin) (8), isoschaftside (6-C-α-l-arabinosyl-8-C-β-d-glucopyranosyl apigenin) (9), isorhamnetin-3-O-β-d-glucopyranoside (10), quercetin-3-O-β-glucuronide (11), 8-O-methylherbacetin-3-O-sophoroside (12) and kaempferol (13), were isolated ...
Badía Concepción - - 2012
Abstract Sugar-oligoamides have been designed and synthesized as structurally simple carbohydrate-based ligands to study carbohydrate-minor groove DNA interactions. Here we report an efficient in solution-phase synthetic strategy to obtain two broad families of sugar-oligoamides. The first type, structure vector A (-Py[Me]--Py-Ind), has a methyl group present as a substituent on ...
Scherpenisse Mirte - - 2012
The bivalent HPV16/18 vaccine induces high antibody concentrations in serum while data about antibody responses in the cervix are limited. In this study, we investigated pre- and post-vaccination antibody responses against seven high-risk HPV types by detection of IgG and IgA HPV-specific antibodies in cervical secretion samples (CVS) and serum. ...
Lagang Manuel - - 2012
The closed-loop operation of brain-machine interfaces (BMI) provides a framework to study the mechanisms behind neural control through a restricted output channel, with emerging clinical applications to stroke, degenerative disease, and trauma. Despite significant empirically driven improvements in closed-loop BMI systems, a fundamental, experimentally validated theory of closed-loop BMI operation ...
Kahru Anne - - 2012
Some researchers consider nanotechnology the next industrial revolution, and consumer products and a variety of industries increasingly use synthetic nanoparticles. In this Account, we review the initial accomplishments of nanoecotoxicology, a discipline that is just a decade old. This new subdiscipline of ecotoxicology faces two important and challenging problems: the ...
Rodríguez-Morales Olivia - - 2012
ABSTRACT: The only existing preventive measure against American trypanosomosis, or Chagas disease, is the control of the transmitting insect, which has only been effective in a few South American regions. Currently, there is no vaccine available to prevent this disease. Here, we present the clinical and cardiac levels of protection ...
Miłaczewska Anna - - 2012
The mechanism of oxidative epoxidation catalyzed by HppE, which is the ultimate step in the biosynthesis of fosfomycin, was studied by using hybrid DFT quantum chemistry methods. An active site model used in the computations was based on the available crystal structure for the HppE-Fe(II) -(S)-HPP complex and it comprised ...
Keating Brendan - - 2012
When a forensic DNA sample cannot be associated directly with a previously genotyped reference sample by standard short tandem repeat profiling, the investigation required for identifying perpetrators, victims, or missing persons can be both costly and time consuming. Here, we describe the outcome of a collaborative study using the Identitas ...
Chen Xu-Dong - - 2012
Heteroligated cluster cores consisting of weak-field iron, strongly basic nitrogen anions, and sulfide are of interest with respect to observed and conjectured environments in the FeMo cofactor of nitrogenase. Selective syntheses have been developed to achieve such environments with tert-butyl-substituted amide and imide core ligands. A number of different routes ...
Duan Hongliang - - 2012
4-Phenoxy-nicotinamide and 4-phenoxy-pyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists are reported. Several 4-phenoxy-nicotinamide derivatives were found to activate human and mouse TGR5 (hTGR5 and mTGR5) with EC50 values in the low nanomolar range. Compound 23g, with an EC50 value of 0.72 nM on hTGR5 and 6.2 nM on ...
Luckanagul Jittima Amie - - 2012
In regenerative medicine, synthetic extracellular matrix is crucial for supporting stem cells during its differentiation process to integrate into surrounding tissues. Hydrogels are used extensively in biomaterials as synthetic matrices to support the cells. However, in order to mimic the biological niche of a functional tissue, various chemical functionalities are ...
Schlegel Thomas - - 2012
Of the many signals used by honey bees during the process of swarming, two of them-the stop signal and the worker piping signal-are not easily distinguished for both are mechano-acoustic signals produced by scout bees who press their bodies against other bees while vibrating their wing muscles. To clarify the ...
Goh Wei Jiang - - 2012
Biofuels are fast advancing as a new research area to provide alternative sources of sustainable and clean energy. Recent advances in nanotechnology have sought to improve the efficiency of biofuel production, enhancing energy security. In this study, we have incorporated iron oxide nanoparticles into Single-Wall Carbon Nanotubes (SWCNTs) to produce ...
Voronina Ekaterina - - 2012
P granules are conserved cytoplasmic organelles, similar to nuage, that are present in Caenorhabditis elegans germ cells. Based on the prevailing sterility phenotype of the component mutants, P granules have been seen as regulators of germ cell development and function. Yet, specific germline defects resulting from P-granule failure vary, depending ...
de Leon Arnie R - - 2012
Substitution of a nucleobase pair with a pair of 1,2-hydroxypyridinone (1,2-HOPO) ligands in the center of a 10-base-pair peptide nucleic acid (PNA) duplex provides a strong binding site for Eu(III) as evidenced by UV thermal melting curves, UV titrations, and luminescence spectroscopy. Eu(III) excitation spectra and luminescence lifetime data are ...
O'Connor Casey - - 2012
Ras is a small monomeric GTPase acting as molecular switch in multiple cellular processes. The N-terminal G domain of Ras binds GTP or GDP accompanied by a magnesium ion, which is strictly required for GTPase activity and performs a structural role. Another ion-binding site on the opposite face of the ...
Cho Kyunghyun - - 2012
Restricted Boltzmann machines (RBMs) are often used as building blocks in greedy learning of deep networks. However, training this simple model can be laborious. Traditional learning algorithms often converge only with the right choice of metaparameters that specify, for example, learning rate scheduling and the scale of the initial weights. ...
Erovic Boban M - - 2012
Unlike papillary thyroid carcinoma, medullary thyroid carcinoma is insensitive to adjuvant treatment with radioactive iodine. The clinical management of patients with advanced or metastatic disease remains challenging since no effective systemic adjuvant therapy is available. We aimed to identify markers of aggressive disease and novel drugable protein targets that would ...
Peramo Antonio - - 2012
Our laboratory had developed a methodology to expand epithelial cells in culture by growing keratinocyte monolayers, under large volumes of medium that produces large numbers of keratinocytes that leave the monolayer and move into suspension. The cells have been defined as epithelial Pop Up Keratinocytes or ePUKs cells and appear ...
Pesquera D - - 2012
The electron occupancy of 3d-orbitals determines the properties of transition metal oxides. This can be achieved, for example, through thin-film heterostructure engineering of ABO(3) oxides, enabling emerging properties at interfaces. Interestingly, epitaxial strain may break the degeneracy of 3d-e(g) and t(2g) orbitals, thus favoring a particular orbital filling with consequences ...
Peng Xin-Gui - - 2012
Brown adipose tissue (BAT) plays a key role in thermogenesis to protect the body from cold and obesity. White adipose tissue (WAT) stores excess energy in the form of triglycerides. To better understand the genetic effect on regulation of WAT and BAT, we investigated the fat fraction (FF) in two ...
Adini Avner - - 2012
Prominin-1, a pentaspan transmembrane protein, is a unique cell surface marker commonly used to identify stem cells, including endothelial progenitor cells and cancer stem cells. However, recent studies have shown that prominin-1 expression is not restricted to stem cells but also occurs in modified forms in many mature adult human ...
Tang Christine - - 2012
β-Cell lipotoxicity is thought to play an important role in the development of type 2 diabetes. However, no study has examined its role in type 1 diabetes, which could be clinically relevant for slow-onset type 1 diabetes. Reports of enhanced cytokine toxicity in fat-laden islets are consistent with the hypothesis ...
Terranova Claudio - - 2012
The aim of the study is to analyze the factors that are most frequently associated with a verdict of guilty delivered to the psychiatrist in cases of a patient's suicide in Italian law. Twenty-six sentences (1975-2009) were analyzed according to the claim of malpractice, patient characteristics, circumstances of the suicide, ...
Zoller Frederic - - 2012
Frankenstein's peptide: The grafting of the binding domain from miniprotein Min-23 into the sunflower trypsin inhibitor (SFTI-I) peptide scaffold preserved its in vitro and in vivo binding specificity and proteolytic stability. The combination of these peptides was shown to be tumor-specific with a good binding affinity for delta-like ligand 4 ...
Chen Chun - - 2012
Using the stopped-flow circular dichroism (SFCD) technique, we investigate the kinetics of pH-induced folding and unfolding process of DNA i-motif. The results show that the molecule can fold or unfold at a timescale of 100 ms when the solution pH is changed. It is also found that the folding and ...
Su Jing - - 2012
The change ΔR(x) of bond length R(x) for atom X in a molecule upon electronic transition can be derived from the intensities I(i) of the vibrational progression v=0→i of the electronic absorption or emission spectrum. In many cases, a simple model is sufficient for a reasonable estimate of ΔR(x). For ...
Saeki Akinori - - 2012
State-of-the-art low band gap conjugated polymers have been investigated for application in organic photovoltaic cells (OPVs) to achieve efficient conversion of the wide spectrum of sunlight into electricity. A remarkable improvement in power conversion efficiency (PCE) has been achieved through the use of innovative materials and device structures. However, a ...
Endersby N M - - 2012
Two stable infections of Wolbachia pipientis, wMelPop and wMel, now established in Aedes aegypti, are being used in a biocontrol program to suppress the transmission of dengue. Any effects of Wolbachia infection on insecticide resistance of mosquitoes may undermine the success of this program. Bioassays of Ae. aegypti were conducted ...
Schmidt Bernd - - 2012
Enantioselective total syntheses of both enantiomers of the recently isolated decanolide natural product seimatopolide A are described. The C2-symmetric building blocks (R, R)-hexa-1,5-diene-3,4-diol (derived from D-mannitol) and its enantiomer (derived from L-(+)-tartrate) serve as key starting materials, which are elaborated in a bidirectional way using a selective mono cross metathesis, ...
Westermeyer Joseph - - 2012
Goal consists of describing the demographic and comorbid characteristics associated with Posttraumatic Stress Disorder (PTSD) among American Indian veterans with any lifetime Axis 1 disorder. Sample included 252 American Indian veterans, obtained from a community sample of 557, using targeted sampling designed to provide a representative sample, structured to include ...
Fani L - - 2012
PURPOSE: Treating hydrocephalus can be difficult in children under the age of 2 years because a high amount of uncertainty exists as to which treatment to perform. In this retrospective cohort study, we analyzed children under the age of 2 years with hydrocephalus undergoing an endoscopic third ventriculocisternostomy (ETV) with respect to ...
Dottore Alexandre M - - 2012
PURPOSE: This prospective, controlled split-mouth study evaluated the stability of dental implants placed in the augmented mandibular areas with alveolar segmental "sandwich" osteotomies using nonceramic hydroxyapatite (ncHA) or autogenous bone. MATERIAL AND METHODS: This study included 11 bilaterally partially edentulous mandibular patients in a split-mouth design. Alveolar augmentation osteotomies were ...
Malan-Müller Stefanie - - 2012
Epigenetic and regulatory elements provide an additional layer of complexity to the heterogeneity of anxiety disorders. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that have recently drawn interest as epigenetic modulators of gene expression in psychiatric disorders. miRNAs elicit their effects by binding to target messenger RNAs (mRNAs) ...
Bonyár Attila - - 2012
A gray cast iron specimen was investigated by color and chemical etching with optical and atomic force microscopy, and the effect of grain orientation on the effectiveness of etching was examined. It was proven that the grain orientation dependence of chemical and color etching is just the opposite, and that ...
Hicks Rodney J - - 2012
For the evaluation of biological processes using radioisotopes, there are two competing technologies: single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Both are tomographic techniques that enable 3D localization and can be combined with CT for hybrid imaging. PET-CT has clear technical superiority including superior resolution, speed and ...
Eskander Antoine - - 2012
BACKGROUND: There remains controversy surrounding the extent of lateral neck dissection required in patients with papillary thyroid cancer (PTC) and suspicious or confirmed metastatic lateral neck lymphadenopathy. The evidence for this clinical dilemma has never been reviewed systematically nor has there been an attempt to meta-analyze data by level to ...
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