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Lin Qingqing Q Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794-5215, - - 2013
The hypothesis that mismatch between transmembrane (TM) length and bilayer width controls TM protein affinity for ordered lipid domains (rafts) was tested using perfringolysin O (PFO), a pore-forming cholesterol-dependent cytolysin. PFO forms a multimeric barrel with many TM segments. The properties of PFO mutants with lengthened or shortened TM segments ...
Yadollahi Azadeh - - 2012
Tracheal respiratory sound analysis is a simple and non-invasive way to study the pathophysiology of the upper airway and has recently been used for acoustic estimation of respiratory flow and sleep apnea diagnosis. However in none of the previous studies was the respiratory flow-sound relationship studied in people with obstructive ...
Conyers Ryan C - - 2012
With the use of benzonitrile-stabilized Au(I) catalyst [Au(IPr)(NCPh)]SbF(6) (Ic; IPr=1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene), a spectrum of reactivity is observed for propargyl ester 4 a with cyclic vinyl ethers, ranging from exclusively [3C+2C] cycloaddition reactions to exclusively cyclopropanation depending only on the structure of the substrate. Some initially formed cyclopropanation products rearrange into the corresponding ...
Lee Sumin - - 2012
An open and shut case: Photoirradiation of the 9-mesityl-10-methylacridinium ion, which acts as a photoredox catalyst, evoked catalytic cycloreversion of the photochromic 1,2-dithienylethene (DTE) compounds with one order of magnitude enhancement in quantum yields. Mechanistic studies revealed that the back electron transfer and electron transfer from the neutral closed form ...
Na Chan Woong - - 2012
Single-crystalline Mn3O4 nanowires were prepared using the vapor-phase transformation of ZnO nanobelts. Mn3O4-decorated ZnO nanobelts and ZnO-ZnMn2O4 core-shell nanocables (NCs) were also obtained as reaction intermediates. Heteroepitaxial growth of tetragonal spinel Mn3O4 (or ZnMn2O4) on wurtzite ZnO is a possible reason for the growth of single-crystalline Mn3O4 nanowires. Growth interfaces ...
Vácha Robert - - 2012
During passive endocytosis, nanosized particles are initially encapsulated by a membrane separating it from the cytosol. Yet, in many applications the nanoparticles need to be in direct contact with the cytosol in order to be active. We report a simulation study that elucidates the physical mechanisms by which such nanoparticles ...
Deconinck Barbara - - 2012
PURPOSE: The term diffuse parenchymal lung disease (DPLD) refers to a group of disorders affecting the lung parenchyma that can be categorized into those of known and those of unknown etiology. Early diagnosis is important since some forms of DPLD are characterized by a rapid progression to respiratory failure. Notwithstanding ...
Takahashi Yuichi Y Department of Spine and Spinal Surgery, Shinkomonji Hospital, 2-5, Dairishinmachi, Moji, Kitakyushu, Fukuoka 800-0057, Japan. - - 2013
Cervical disc herniation (CDH) is found more frequently at the lower cervical spine than at the upper or middle level. However, there is scarcity of data about the laterality of CDH. The aim of this study is to detect the laterality of CDH. We retrospectively evaluated preoperative computed tomography myelograms ...
Foti Romano - - 2012
With urban, agricultural, and industrial needs growing throughout the past decades, wetland ecosystems have experienced profound changes. Most critically, the biodiversity of wetlands is intimately linked to its hydrologic dynamics, which in turn are being drastically altered by ongoing climate changes. Hydroperiod regimes, e.g., percentage of time a site is ...
Nocera Tanya M - - 2012
In recent years, superparamagnetic nanoparticles (SPNs) have become increasingly important in applications ranging from solid state memory devices to biomedical diagnostic and therapeutic tools. However, detection and characterization of the small and unstable magnetic moment of an SPN at the single particle level remains a challenge. Further, depending on their ...
Bhatt Surya P - - 2012
Pursed lips breathing (PLB) is used by a proportion of patients with chronic obstructive pulmonary disease (COPD) to alleviate dyspnea. It is also commonly used in pulmonary rehabilitation. Data to support its use in patients who do not spontaneously adopt PLB are limited. We performed this study to assess the ...
Egbunike Veronica - - 2012
PurposeThe purpose of the research was to investigate the impact of point-of-care (POC) A1C testing among patients with type 2 diabetes in a primary care setting.MethodsThis study used a pretest-posttest design with data from patient charts matched for age, sex, race, body mass index, insurance status, and the number of ...
Kim Eun Ji EJ Department of Chemistry and Nano Sciences, Ewha Womans University, Seoul 120-750, Republic of - - 2012
Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.
Wu Jun - - 2012
The draft genome of pear (Pyrus bretschneideri) using a combination of BAC-by-BAC and next generation sequencing is reported. A 512.0 Mb sequence corresponding to 97.1% of the estimated genome size of this highly heterozygous species is assembled with 194x coverage. High-density genetic maps comprising of 2,005 SNP markers anchored 75.5% ...
Kim Seon Sook - - 2012
Regulator of calcineurin 1 (RCAN1) is located on the Down syndrome critical region (DSCR) locus in human chromosome 21. In this study, we investigated the functional role of RCAN1 in the reactive oxygen species (ROS)-mediated neuronal death signaling. We found that RCAN1 was able to protect the cells from H(2) ...
Zhang Yi - - 2012
Penicillium sp. MA-37, which was obtained from the rhizospheric soil of the mangrove plant Bruguiera gymnorrhiza, exhibited different chemical profiles in static and shaken fermentation modes. Three new meroterpenoid derivatives, 4,25-dehydrominiolutelide B (1), 4,25-dehydro-22-deoxyminiolutelide B (2), and isominiolutelide A (3), together with three known ones were characterized from its static ...
De Leon Joaquin J Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968, - - 2012
Mycobacterium tuberculosis ESAT-6 (MtbESAT-6) reportedly shows membrane/cell-lysis activity, and recently its biological roles in pathogenesis have been implicated in rupture of the phagosomes for bacterial cytosolic translocation. However, molecular mechanism of MtbESAT-6-mediated membrane interaction, particularly in relation with its biological functions in pathogenesis, is poorly understood. In this study, we ...
Bae Sun Ju - - 2012
A spheroidal transgene-networked gel matrix was designed as a synthetic nucleus system. It was spherodically manufactured using both advanced lithography and DNA nanotechnology. Stable Aqueorea coerulescens green fluorescent protein (AcGFP) encoding gene cross-networks have been optimized in various parameters; the number of G-net-gel spheroids, the concentration of a AcGFP plasmid ...
Patel Manali I - - 2012
BACKGROUND: The gastric cancer AJCC/UICC staging system recently underwent significant revisions, but studies on Asian patients have reported a lack of adequate discrimination between various consecutive stages. We sought to validate the new system on a U.S. population database. METHODS: California Cancer Registry data linked to the Office of Statewide ...
Singh Dharmendra D Department of Molecular Biology, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna, Bihar, India. - - 2013
The definitive diagnosis of visceral leishmaniasis (VL) requires invasive procedures for demonstration of parasites in tissue smear or culture. These procedures need expertise and laboratory supports and cannot be performed in the field. The aim of the present study was to evaluate the existing rK-39 immunochromatographic nitrocellulose strips test (ICT) ...
Divito Michael D - - 2012
PURPOSE: TO INVESTIGATE COMPOSITIONS OF SILICA-COLLAGEN HYBRID MATERIALS AS POTENTIAL ARTIFICIAL CORNEAL SUBSTITUTES, AND HOW THESE COMPONENTS AFFECT THE OPTICAL AND BIOMECHANICAL PROPERTIES OF THE HYBRIDS, AND THEIR BIOCOMPATIBILITY IN AN ORGAN CULTURE MODEL. METHODS: Hybrid materials were created from different proportions of collagen and silica precursors, and manufactured to ...
Millán Alba - - 2012
A versatile Ti/Ni multimetallic protocol is described for the efficient catalysis of two different reactions, namely a Heck- and reductive-type cyclization of alkyl iodides, in the absence or presence of water, respectively. Noteworthy, the versatility of Ti(III) chemistry allows an oxidative ending step under reductive conditions to give Heck-type products, ...
McGhie David - - 2012
BACKGROUND:Excessive repetitive loads are widely believed to be the cause of overload or overuse injuries. On third-generation artificial turf, impacts have been found to vary with surface and shoe properties. Mechanical devices are considered not representative for measuring impact absorption during athletic movements, and pressure insoles have been shown as ...
Fedoroff Nina V - - 2012
In 1950, Barbara McClintock published a Classic PNAS article, "The origin and behavior of mutable loci in maize," which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile genetic element she ...
Kong Yun - - 2012
This study is aimed at controlling eutrophication through converting the nutrients such as nitrogen and phosphorus into microbial protein and simultaneously inhibiting the growth of Microcystis aeruginosa by Candida utilis. C. utilis and M. aeruginosa (initial cell density was 2.25 × 10(7) and 4.15 × 10(7) cells·mL(-1)) were cultured together in the absence or ...
Ikeuchi Kazutada - - 2012
Asymmetric bromolactonization of prochiral cyclohexadiene derivatives with N-bromosuccimide proceeded in the presence of (DHQD)(2)PHAL as a chiral catalyst to afford the corresponding bromolactones with up to 93% ee. This reaction was also applicable to the kinetic resolution of a racemic cyclic ene-carboxylic acid, where the starting material was recovered with ...
Emmeline Yeo Pei Shan - - 2012
Using a combination of accurate density-functional theory and a nonequilibrium Green's function method, we calculate the ballistic thermal conductance characteristics of tensile-strained armchair (AGNR) and zigzag (ZGNR) edge graphene nanoribbons, with widths between 3 and 50 Å. The optimized lateral lattice constants for AGNRs of different widths display a three-family behavior ...
Gahete Manuel D MD Research and Development Division, University of Illinois at Chicago, Chicago, IL 60612, - - 2013
In mice, GH levels rise in response to short-term fasting or starvation (food restriction to 40% of ad libitum intake), similar to that which occurs in humans in response to fasting or anorexia. Recent studies using acyl-ghrelin knockout mice have suggested that the rise in GH during food restriction is ...
Carpentier Nicolas - - 2012
The adherence to medication in drug-resistant focal epilepsy (RFE) remains largely unknown. The present work aimed to assess the frequency of recent adherence to antiepileptic drugs (AEDs) in patients with RFE. This prospective observational study screened all patients with RFE, admitted to the Nancy University Hospital between April 2006 and ...
Truong Thanh T Department of Chemistry, University of Houston, Houston, Texas 77204-5003, - - 2012
A method for direct, transition-metal-free ortho-arylation of anilines by aryl chlorides, bromides, fluorides, and triflates has been developed. This methodology provides the most direct approach to 2-arylanilines since no protecting or directing groups on nitrogen are required. The arylation is functional-group tolerant, with alkene, ether, trifluoromethyl, dimethylamino, carbonyl, chloro, and ...
Gobbo João Paulo - - 2012
The photophysics of 8-azaadenine (8-AA) has been studied with the CASPT2//CASSCF protocol and ANO-L double-ζ basis sets. Stationary equilibrium structures, surface crossings, minimum energy paths and linear interpolations have been used to study possible mechanisms to populate the lowest triplet state, T(1) (3)(ππ(*)), capable of sensitizing molecular oxygen. Our results ...
Drake G - - 2012
BACKGROUND: Moodscope is an entirely service-user-developed online mood-tracking and feedback tool with built-in social support, designed to stabilize and improve mood. Many free internet tools are available with no assessment of acceptability, validity or usefulness. This study provides an exemplar for future assessments. Method A mixed-methods approach was used. Participants ...
Cucchiarini Magali - - 2012
Direct gene transfer strategies are of promising value to treat articular cartilage defects. Here, we tested the ability of a recombinant adeno-associated virus (rAAV) SOX9 vector to enhance the repair of cartilage lesions in vivo. The candidate construct was provided to osteochondral defects in rabbit knee joints vis-à-vis control (lacZ) ...
Okuda Shujiro - - 2012
Microbial ecologists have investigated roles of species richness and diversity in a wide variety of ecosystems. Recently, metagenomics have been developed to measure functions in ecosystems, but this approach is cost-intensive. Here we describe a novel method for the rapid and efficient reconstruction of a virtual metagenome in environmental microbial ...
Patterson Sherri L - - 2012
BACKGROUND:Cancer has traditionally been considered a single disease, but it is now known to be far more complex, with an unfolding etiology. In less than 2 centuries, hundreds-if not thousands-of drugs for the treatment of cancer and for palliative care have been developed and tested, with 143 having achieved approval ...
Scheitz Cornelia Johanna Franziska - - 2012
The transcription factor Runx1 has been studied in leukemia and blood for decades, but recently it has been also implicated in epithelial biology and pathology. Particularly in mouse skin Runx1 modulates Wnt signaling levels thereby regulating timely induction of hair follicle specification, proper maturation of the emerging adult hair follicle ...
Canis Martin - - 2013
The pentaspan protein CD133 (Prominin-1) is part of the signature of tumour-initiating cells for various cancer entities. The aim of the present study was to investigate the impact of ectopic CD133 expression on tumourigenic properties of otherwise CD133-negative, non-tumourigenic cells in vitro and in vivo. CD133 was stably transfected into ...
Kim Oh Yoen - - 2012
This study investigates the association among metabolic risk factors, inflammatory and oxidative stress markers, and brachial-ankle pulse wave velocity (ba-PWV). We conducted a 3-year longitudinal, observational study of 288 middle-aged adults not meeting the criteria for metabolic syndrome (MetS) at the initial screening. We measured metabolic risk factors, inflammatory and ...
Puchulu-Campanella Estela E Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, - - 2013
Glycolytic enzymes (GEs) have been shown to exist in multienzyme complexes on the inner surface of the human erythrocyte membrane. Because no protein other than band 3 has been found to interact with GEs, and because several GEs do not bind band 3, we decided to identify the additional membrane ...
Liu Dan-Dan - - 2012
The extensive applications of cerium (Ce) increased the chance of human exposure to Ce and its compounds. It was reported that Ce was mainly deposited in the bone after administration. However, the potential effect and mechanism of Ce on bone metabolism are not well-understood. In this study, we investigated the ...
Feiring Candice C Center for Youth Relationship Development, The College of New Jersey, Ewing 08628–0718, USA. - - 2013
Although experiencing childhood sexual abuse (CSA) puts youth at risk for involvement in relationship violence, research is limited on the potential pathways from CSA to subsequent dating aggression. The current study examined prospective pathways from externalizing behavior problems and stigmatization (abuse-specific shame and self-blame attributions) to anger and dating aggression. ...
Lölsberg Wibke - - 2012
A short and enantioselective total synthesis of helioporins C and E, which are bioactive marine diterpenes containing a serrulatane or amphilectane skeleton, was elaborated. The chirogenic step, i.e. a Cu(I)-catalyzed allylic alkylation of a cinnamyl chloride with methylmagnesium bromide, proceeded with virtually complete enantioselectivity (99% ee) in the presence of ...
Zhu Haiming - - 2012
Recent reports of multiexciton generation (MEG), a process by which one absorbed photon generates multiple excitons, in lead chalcogenide nanocrystals (NCs) have intensified research interest in using this phenomenon to improve the efficiency of solar energy conversion. Practical implementation of MEG processes in solar cells and solar-to-fuel conversion devices requires ...
Wu Hai-Hong - - 2012
The heterometallic appended {MMn(III)(4)} (M = Dy(3+) and K(+)) cubanes were firstly trapped by two diamagnetic POM shells, which were robust enough to construct inorganic crystalline tubular materials. Magnetic study reveals the presence of a SMM-like slow magnetic relaxation feature in the heterometallic cluster-containing POM.
Hatam Gholam Reza - - 2012
Leishmania tropica is one of the main etiological agents of cutaneous leishmaniasis in Iran. For ultrastructural and isoenzyme study, axenic amastigotes were cultured in a brain-heart infusion medium containing 20 % fetal calf serum, pH 4.5, and incubated at 37 °C in 5 % CO(2). Different stages of L. tropica revealed the same isoenzyme ...
Kunte Hagen - - 2012
A 62-year-old man was admitted after recurrent transient left-sided weakness and sensory loss. Ultrasound (US) examination revealed a 70% narrowing of the right proximal internal carotid artery (ICA). Contrast-enhanced US suggested plaque neovascularization (figure, A). Carotid endarterectomy of the right ICA was performed. Immunohistochemistry of the specimen showed, corresponding to ...
Yamashiro Tsuneo - - 2012
We report a case of ileal internal hernia through the foramen of Winslow into the lesser sac. Preoperative computed tomography (CT) demonstrated that the herniated ileum, which showed a closed-loop obstruction, was located behind the portal vein, and the vein was subsequently compressed and narrowed by the herniated ileum. We ...
Malone K M - - 2012
Aims. Youth and young adult suicide has increasingly appeared on international vital statistics as a rising trend of concern in age-specific mortality over the past 50 years. The reporting of suicide deaths in 5-year age bands, which has been the international convention to date, may mask a greater understanding of ...
Wakefield Alison M - - 2012
Bcl3 is a putative proto-oncogene deregulated in hematopoietic and solid tumours. Studies in cell lines suggest that its oncogenic effects are mediated through the induction of proliferation and inhibition of cell death, yet its role in endogenous solid tumours has not been established. Here we address the oncogenic effect of ...
Fearon Patrica - - 2012
The modified Rankin Scale (mRS) is the recommended functional outcome assessment in stroke trials. Utility of mRS may be limited by interobserver variability. prestroke function, described using mRS, is often used as trial entry criterion. We assessed the reliability and validity of prestroke mRS in acute stroke. We present two ...
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