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Liu Dan-Dan - - 2012
The extensive applications of cerium (Ce) increased the chance of human exposure to Ce and its compounds. It was reported that Ce was mainly deposited in the bone after administration. However, the potential effect and mechanism of Ce on bone metabolism are not well-understood. In this study, we investigated the ...
Zheng Yalin - - 2012
PURPOSE: To describe and evaluate an automated grading system for age-related macular degeneration (AMD) by color fundus photography. METHODS: An automated "disease / no disease" grading system for AMD was developed based on image mining techniques. First, image pre-processing was performed to normalize color and non-uniform illumination of the fundus ...
Szakiel Anna - - 2012
Analysis of the main triterpenoid profile of chloroform-soluble cuticular waxes of heather flowers and leaves by GC-MS revealed the following composition: five triterpene acids - betulinic, oleanolic, ursolic, 3-oxo-olean-12-en-28-oic and 3-oxo-ursan-12-en-28-oic; eight monohydroxyalcohols - α-amyrin, β-amyrin, cycloartanol, 24-methylenecycloartanol, friedelinol, germanicol, lupeol and taraxasterol; three dihydroxyalcohols - betulin, erythrodiol and uvaol; ...
Renault Hugues - - 2012
Environmental constraints challenge cell homeostasis and thus require a tight regulation of metabolic activity. We have previously reported that the γ-aminobutyric acid (GABA) metabolism is crucial for Arabidopsis salt tolerance as revealed by the NaCl hypersensitivity of the GABA transaminase (GABA-T, At3g22200) gaba-t/pop2-1 mutant. In this study we demonstrate that ...
Esfandiary Reza - - 2012
In addition to controlling typical instabilities such as physical and chemical degradations, understanding monoclonal antibodies' (mAbs) solution behavior is a key step in designing and developing process and formulation controls during their development. Reversible self-association (RSA), a unique solution property in which native, reversible oligomeric species are formed as a ...
Elze J - - 2012
SUMMARY The objective of this study was to identify the most reliable approach for prevalence estimation of Mycobacterium avium ssp. paratuberculosis (MAP) infection in clinically healthy slaughtered cattle. Sampling of macroscopically suspect tissue was compared to systematic sampling. Specimens of ileum, jejunum, mesenteric and caecal lymph nodes were examined for ...
Scalas L Francesca - - 2012
The individually importance-weighted average (IIWA) model posits that the contribution of specific areas of self-concept to global self-esteem varies systematically with the individual importance placed on each specific component. Although intuitively appealing, this model has weak empirical support; thus, within the framework of a substantive-methodological synergy, we propose a multiple-item ...
Wang Hong-Mei - - 2012
PURPOSE: We examine age- and sex-specific associations between weight status and intensity of cigarette smoking in a large sample of adolescents. Additionally, we test whether quality of life (QOL) and weight control behaviors (i.e., trying to lose, gain, or stay the same weight) mediate the association. METHODS: We used cross-sectional ...
Sharma Bhuey - - 2012
Over the past 120 years, the discipline of oncology has evolved so that a multitude of anatomical and increasingly complex functional imaging techniques are now applicable in both clinical and research platforms. This Timeline article revisits the achievements of the pioneer techniques in cancer imaging, discusses how these techniques have ...
Vaish Vivek - - 2012
Initiation of various cancers has been observed to be regulated via a prolonged inflammatory state in the tissues. However, molecular role of such a localized inflammation is not clear in the advanced stages of colorectal cancer. In this study, we have elaborated the role of various pro- and anti-inflammatory cytokines, ...
Stanutz Sandy - - 2012
Background: Pitch perception is enhanced among persons with autism. We extended this finding to memory for pitch and melody among school-aged children.Objective: The purpose of this study was to investigate pitch memory in musically untrained children with autism spectrum disorders, aged 7-13 years, and to compare it to that of ...
Pauly Aude - - 2012
PURPOSE: To compare in vitro, on the human reconstituted corneal epithelial SkinEthics model, and in vivo, using an acute rabbit toxicological model, the effects of a benzalkonium chloride (BAK)-preserved solution of latanoprost and a preservative-free (PF) latanoprost solution. METHODS: In vitro, the 3D reconstituted human corneal epithelia (HCE) were treated ...
Okazaki Fumiyoshi - - 2012
The biochemical properties of a putative β-1,3-xylanase from the hyperthermophilic eubacterium Thermotoga neapolitana DSM 4359 were determined from a recombinant protein (TnXyn26A) expressed in Escherichia coli. This enzyme showed specific hydrolytic activity against β-1,3-xylan and released β-1,3-xylobiose and β-1,3-xylotriose as main products. It displayed maximum activity at 85 °C during a ...
Sawama Yoshinari - - 2012
Deuterium-labeled sugars can be utilized as powerful tools for the architectural analyses of high-sugar-containing molecules represented by the nucleic acids and glycoproteins, and chiral building blocks for the syntheses of new drug candidates (heavy drugs) due to their potential characteristics, such as simplifying the (1) H NMR spectra and the stability ...
Khan Mosin S - - 2012
High incidence of thyroid cancer worldwide indicates the importance of studying genetic alterations that lead to its carcinogenesis. Specific acquired RAS mutations have been found to predominate in different cancers, and HRAS T81C polymorphism has been determined to contribute the risk of various cancers, including thyroid cancer. We screened the ...
Chang Yuan-Ming - - 2012
The structural and optoelectronic properties of ZnO nanopillars (ZnO-NPs) grown on Si substrates by vapor transport deposition method were investigated. In particular, by varying the deposition duration and hence the morphology of the vertically aligned ZnO-NPs, the resultant field emission characteristics were systematically compared. In addition to identifying the advantageous ...
Jan Jeng-Shiung - - 2012
A simple and versatile approach is proposed to use cross-linked polypeptide hydrogels as templates for silica mineralization, allowing the synthesis of polypeptide-silica hybrid hydrogels and mesoporous silica (meso-SiO2) by subsequent calcination. The experimental data revealed that the cross-linked polypeptide hydrogels comprised of interconnected, membranous network served as templates for the ...
Fung Constance H - - 2012
PURPOSE: Little is known about the ease of use of positive airway pressure (PAP) equipment and whether PAP equipment usability is associated with adherence. This pilot project aims to determine whether perceived difficulty with the mechanics of using PAP equipment is associated with nonadherence. METHODS: Within a larger study of ...
Panazzolo Diogo G - - 2012
ABSTRACT: BACKGROUND: We aimed to evaluate the multivariate association between functional microvascular variables and clinical-laboratorial-anthropometrical measurements. METHODS: Data from 189 female subjects (34.0+/-15.5 years, 30.5+/-7.1 kg/m2), who were non-smokers, non-regular drug users, without a history of diabetes and/or hypertension, were analyzed by principal component analysis (PCA). PCA is a classical ...
Lu Xun - - 2012
MafA is a proto-oncoprotein, and is critical for insulin gene expression in pancreatic β-cells. Maf proteins belong to the AP1 superfamily of basic region-leucine zipper (bZIP) transcription factors. Residues in the basic helix and an ancillary N-terminal domain, the Extended Homology Region (EHR), endow maf proteins with unique DNA binding ...
Darling Katharine Elizabeth Anna - - 2012
OBJECTIVES: Street-based sex workers (SSWs) in Lausanne, Switzerland, are poorly characterised. We set out to quantify potential vulnerability factors in this population and to examine SSW healthcare use and unmet healthcare requirements. METHODS: We conducted a cross-sectional questionnaire-based survey among SSWs working in Lausanne's red light district between 1 February ...
Dmytriyeva Oksana - - 2012
Identification of novel pro-survival factors in the brain is paramount for developing neuroprotective therapies. The multifunctional S100 family proteins have important roles in many human diseases and are also upregulated by brain injury. However, S100 functions in the nervous system remain unclear. Here we show that the S100A4 protein, mostly ...
Lee Ah Young - - 2012
BACKGROUND: Widespread white matter (WM) pathology in preterm children has been proposed. OBJECTIVE: The purpose of this study was to investigate maturational differences of WM between preterm infants with thinning of the corpus callosum and full-term infants. MATERIALS AND METHODS: A total of 18 preterm children and 18 full-term children ...
Stiefel Klaus M - - 2012
This letter discusses temporal order coding and detection in nervous systems. Detection of temporal order in the external world is an adaptive function of nervous systems. In addition, coding based on the temporal order of signals can be used as an internal code. Such temporal order coding is a subset ...
Shirota Hideaki - - 2012
We report here the low-frequency spectra, resulting from the intermolecular/interionic vibrational dynamics, of aqueous mixtures of an ionic liquid, 1-methyl-3-n-octylimidazolium tetrafluoroborate, with the H(2)O mole fractions of 0.2, 0.4, and 0.6 and the neat ionic liquid and H(2)O within the frequency range of 0.1-700 cm(-1) by means of femtosecond Raman-induced ...
Luo Wenping - - 2012
Uterine decidualization, characterized by stromal cell proliferation and differentiation into polyploid decidual cells, is critical to the establishment of prgnancy in mice, although the mechanism underlying this process remains poorly understood. This study is the first to investigate the expression of gamma-amino butyric acid (GABA) and the GABA A-type receptor ...
Jung Sang-Myung - - 2012
The central nervous system (CNS), once injured, rarely recovers original function mainly due to its limited regeneration ability. Astrocytes are cells that play critical roles in neural regeneration. Several biomaterials have been studied to replace and regenerate lost tissues within injured CNS. Seaweeds have extracellular polymeric substances (EPS) with bioactive ...
Uhlemann Madlen - - 2012
Background: MicroRNAs (miRNAs) are small non-coding molecules regulating gene expression. Recently circulating miRNAs could be detected in the plasma, serving as novel biomarkers. Different forms of exercise mobilize progenitor cells from the bone marrow, helping in tissue repair. Data of different forms of exercise on endothelial cell damage are lacking. ...
Mai Yosuke - - 2012
Nicotine- and tar-free cigarette smoke extract (CSE) is reported to induce cell damage via activation of protein kinase C (PKC) and NADPH oxidase (NOX) in rat C6 glioma cells. Here we determined PKC isozyme(s) activated by CSE and their activation mechanism. In C6 glioma cells, mRNAs for PKCα, PKCδ, PKCε, ...
Singh Jagdeep K - - 2012
PURPOSE: Breast cancer stem-like cells (CSCs) are an important therapeutic target as they are predicted to be responsible for tumour initiation, maintenance and metastases. Interleukin-8 (IL-8) is upregulated in breast cancer and associated with poor prognosis. Breast cancer cell line studies indicate that IL-8 via its cognate receptors, CXCR1 and ...
Whitehead Terence R - - 2012
Management practices from large-scale swine production facilities have resulted in the increased collection and storage of manure for off-season fertilization use. Odor and emissions produced during storage have increased the tension among rural neighbors and among urban and rural residents. Production of these compounds from stored manure is the result ...
Thongsri Yordhathai - - 2012
AIMS: Screening of bacterial flora for strains producing metabolites with inhibitory effects on the human pathogenic oomycete Pythium insidiosum. Separation and characterization of extracts from Pseudomonas stutzeri with anti-Pythium inhibitory activity. Search for genes with anti-Pythium effect within the genome of P. stutzeri. METHODS: A total of 88 bacterial strains ...
Gerbeth Kathleen - - 2012
Nonsteroidal anti-inflammatory drug intake is associated with a high prevalence of gastrointestinal side effects, and severe cardiovascular adverse reactions challenged the initial enthusiasm in cyclooxygenase-2 inhibitors. Recently, it was shown that myrtucommulone, the active ingredient of the Mediterranean shrub Myrtus communis, dually and potently inhibits microsomal prostaglandin E2 synthase-1 and ...
Hälvin Kristel - - 2012
The application of LC/MS-TOF method combined with stable isotope dilution assay was studied for determination of thiamine, riboflavin, nicotinamide, nicotinic acid, pantothenic acid, pyridoxal, and pyridoxine in food. Nutritional yeast powder was used as a model food matrix. Acid extraction was compared with various enzymatic treatments in ammonium formate buffer ...
Zhang Aihua - - 2012
Hepatocellular carcinoma (HCC) is the commonest primary hepatic malignancy and the third most common cause of cancer-related death worldwide. Incidence remains highest in the developing world and is steadily increasing across the developed world. Current diagnostic modalities, of ultrasound and α-fetoprotein, are expensive and lack sensitivity in tumour detection. Because ...
McLaurin Emily J - - 2012
Alloyed Zn(1-x-y)Cd(x)Mn(y)Se nanocrystals exhibiting bright intrinsic dual emission attractive for ratiometric optical nanothermometry are reported. Relative to earlier materials with related dual emission, these alloy nanocrystals require shorter syntheses, contain less Cd(2+), and show dual emission that is less sensitive to nanocrystal shape, size, or surfaces.
Cao Mao-Sheng - - 2012
Light-weight nanocomposites filled with carbon nanotubes (CNTs) are developed for their significant potentials in electromagnetic shielding and attenuation for wide applications in electronics, communication devices and specific parts in aircrafts and vehicles. Specifically, the introduction of a second phase into/onto CNTs for achieving CNT-based heterostructures has been widely pursued due ...
Linnenschmidt Meike - - 2012
During echolocation, toothed whales produce ultrasonic clicks at extremely rapid rates and listen for the returning echoes. The auditory brainstem response (ABR) duration was evaluated in terms of latency between single peaks: 5.5 ms (from peak I to VII), 3.4 ms (I-VI), and 1.4 ms (II-IV). In comparison to the killer whale and ...
Xu Su-Yang - - 2012
A topological insulator protected by time-reversal symmetry is realized via spin-orbit interaction-driven band inversion. The topological phase in the Bi(1-x)Sb(x) system is due to an odd number of band inversions. A related spin-orbit system, the Pb(1-x)Sn(x)Te, has long been known to contain an even number of inversions based on band ...
Lei Ming - - 2012
Compared to other cereals, rice has particular strong As accumulation. Therefore, it is very important to understand As uptake and translocation among different genotypes. A field study in Chenzhou city, Hunan province of China, was employed to evaluate the effect of arsenic-contaminated soil on uptake and distribution in 34 genotypes ...
Balakrishnan Balamuralithara - - 2012
The unique properties of nanotechnology have made nanotechnology education and its related subjects increasingly important not only for students but for mankind at large. This particular technology brings educators to work together to prepare and produce competent engineers and scientists for this field. One of the key challenges in nanotechnology ...
Clardy Stacey L - - 2012
Autoimmune and immune-mediated mechanisms are increasingly appreciated in many neurologic diseases. The goal of fellowship training is to develop an understanding of the pathophysiology and treatment of these diseases with a focus on immunology that is not traditionally afforded to most trainees during residency or fellowship. Neuroimmunology is an expanding ...
Lo Hong-Jay - - 2012
A chiral pool based synthetic strategy that leads from the readily available and inexpensive C(2)-symmetric tartaric acids to the chiral O-isopropylidenebenzooxazole-a convenient precursor to the aminocyclitol core of hygromycin A as well as the chiral γ-disilyloxybutyrolactone-a pivotal intermediate to approach to the furanoside of hygromycin A.
Guo Yuming - - 2012
OBJECTIVE: To examine the effects of extremely cold and hot temperatures on ischaemic heart disease (IHD) mortality in five cities (Beijing, Tianjin, Shanghai, Wuhan and Guangzhou) in China; and to examine the time relationships between cold and hot temperatures and IHD mortality for each city. DESIGN: A negative binomial regression ...
Ai Lunhong - - 2012
Uniform quaternary Cu(2)FeSnS(4) (CITS) nanotubes of outer diameter 400-800 nm and thickness 100-200 nm have been synthesized for the first time by a simple, rapid and easily scaled-up microwave nonaqueous route using benzyl alcohol as the microwave absorbing solvent. An interesting in situ generated one-dimensional Cu(Tu)Cl nanorod acting as a self-sacrificial template ...
Mahmood Qasim - - 2012
Hierarchical structures of transition metal oxides with well-defined compositions are crucial for achieving advanced electrodes for energy storage devices. Herein, we first demonstrate the hierarchically structured MoO(3) assembled by twisted nanoribbons with a hybrid composition for improved rate capability and cycle stability of the pseudocapacitor. The hierarchical, flower-like structures of ...
Coronado Eugenio - - 2012
A three-dimensional coordination polymer, [Cu(btix)(2)(BF(4))(2)](n) [btix = 1,4-bis(triazol-1-ylmethyl)benzene], with antiferromagnetic interactions occurring via the organic ligand, has been prepared and characterized. It has been shown to permit the exchange of anionic species in the crystalline network with modification of the magnetic properties. Coordinated BF(4)(-) can be reversibly exchanged by different ...
Marcus Michael W - - 2012
BACKGROUND: It is largely unknown if corticosteroid-induced open-angle glaucoma (OAG) is an entity that is limited to a few susceptible individuals or whether it contributes significantly to the overall population burden of OAG. OBJECTIVE: The aim of this study was to determine whether there is an association between corticosteroid use ...
Deconinck Barbara - - 2012
PURPOSE: The term diffuse parenchymal lung disease (DPLD) refers to a group of disorders affecting the lung parenchyma that can be categorized into those of known and those of unknown etiology. Early diagnosis is important since some forms of DPLD are characterized by a rapid progression to respiratory failure. Notwithstanding ...
Nocera Tanya M - - 2012
In recent years, superparamagnetic nanoparticles (SPNs) have become increasingly important in applications ranging from solid state memory devices to biomedical diagnostic and therapeutic tools. However, detection and characterization of the small and unstable magnetic moment of an SPN at the single particle level remains a challenge. Further, depending on their ...
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