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Results 501 - 550 of 2032
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Hill Jeff T - - 2012
Both classical and quantum systems utilize the interaction of light and matter across a wide range of energies. These systems are often not naturally compatible with one another and require a means of converting photons of dissimilar wavelengths to combine and exploit their different strengths. Here we theoretically propose and ...
Shang Yanwei - - 2012
Superhydrophobic and superoleophilic nanofibrous membranes exhibiting robust oil-water separation performance were prepared by a facile combination of electrospun cellulose acetate (CA) nanofibers and a novel in situ polymerized fluorinated polybenzoxazine (F-PBZ) functional layer that incorporated silica nanoparticles (SiO(2) NPs). By employing the F-PBZ/SiO(2) NPs modification, the pristine hydrophilic CA nanofibrous ...
Huang Han-Bin - - 2012
BACKGROUND: Exposure to traffic-related air pollutants, including polycyclic aromatic hydrocarbons (PAHs) and heavy metals, has been associated with the etiology and prognosis of many illnesses. However, the specific causal agents and underlying mechanisms for different health outcomes remain unclear. The aims of this study were to assess the relations between ...
Ciborowski Michal - - 2012
Ozonated autohemotherapy (O(3)-AHT) is a medical approach during which blood obtained from the patient is ozonated and injected back into the body. Despite an increasing number of evidences that O(3)-AHT is safe, this type of therapy remains controversial. To extend knowledge about the changes in blood evoked by O(3)-AHT LC-MS ...
Noguera Aina - - 2012
ABSTRACT: BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is characterized by an enhanced inflammatory response to smoking that persists despite quitting. The resolution of inflammation (catabasis) is a complex and highly regulated process where tissue resident macrophages play a key role since they phagocytose apoptotic cells (efferocytosis), preventing their secondary necrosis ...
Joya Yasir F - - 2012
Anatase-based titanium dioxide (TiO(2)) naturally possesses a well recognized antibacterial effect under ultraviolet excitation. However, anatase modified with silver nanoparticles (Ag NPs) exhibits even stronger antibacterial action in natural daylight. The purpose of our present research is to evaluate the photocatalytic antibacterial effects of laser-generated silver-anatase nanocomposite film against Escherichia ...
Behringer Karolin - - 2012
PURPOSETo optimize fertility advice in patients with Hodgkin lymphoma (HL) before therapy and during survivorship, information on the impact of chemotherapy is needed. Therefore, we analyzed gonadal functions in survivors of HL. PATIENTS AND METHODSWomen younger than age 40 and men younger than 50 years at diagnosis in ongoing remission ...
Hammond Ceri - - 2012
The partial oxidation of methane to methanol presents one of the most challenging targets in catalysis. Although this is the focus of much research, until recently, approaches had proceeded at low catalytic rates (<10 h(-1) ), not resulted in a closed catalytic cycle, or were unable to produce methanol with a ...
Hurcombe Samuel D - - 2012
OBJECTIVE: To document whether presumptive bacterial translocation (PBT) occurs in horses with small intestinal strangulation (SIS). DESIGN: Prospective clinical cohort study. SETTING: University tertiary care facility. ANIMALS: Thirty-six adult horses with SIS (clinical cases) and 10 adult horses without gastrointestinal disease (control cases). INTERVENTIONS: Sterile collection and bacterial culture of ...
Pool Stefan Ernest - - 2012
Inhibition of mTOR (mammalian target of rapamycin) is commonly considered a valid target in cancer treatment, but this assertion does not address effects on the immune microenvironment that may be detrimental to cancer treatment. Here we show how administration of the mTOR inhibitor RAD001 (everlimus) results in occurrence of distant ...
de Smet Marc D - - 2012
PURPOSE: Ocriplasmin contains the active moiety of plasmin enzyme. At a physiologic pH, ocriplasmin is highly proteolytic and autolytic, limiting its duration of activity. Specific inhibitors of plasmin are present in the vitreous under normal and disease conditions and could affect its activity. Each may contribute to its mode of ...
Berbeco Ross I RI Department of Radiation Oncology, Division of Medical Physics and Biophysics, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA. - - 2012
In this study, we quantify the relative damage enhancement due to the presence of gold nanoparticles (GNP) in vitro in a clinical 6 MV beam for various delivery parameters and depths. It is expected that depths and delivery modes that produce a larger proportions of low-energy photons will have a ...
Liu Xiang - - 2012
It is accepted that the ligand shell morphology of nanoparticles coated with a monolayer of molecules can be partly responsible for important properties such as cell membrane penetration and wetting. When binary mixtures of molecules coat a nanoparticle, they can arrange randomly or separate into domains, for example, forming Janus, ...
Ochieng Charles O - - 2012
With reference to the ethnopharmacological significance of Vitex doniana Sweet (Lamiaceae) leaves in the treatment of stomach and rheumatic pains as well as inflammatory disorders, biological studies on its stem bark extracts have also reported anti-inflammatory and analgesic activities, with no attempt to identify the active components. Chromatographic and spectroscopic ...
Harrison Matthew T - - 2012
Controlling for multiple hypothesis tests using standard spike resampling techniques often requires prohibitive amounts of computation. Importance sampling techniques can be used to accelerate the computation. The general theory is presented, along with specific examples for testing differences across conditions using permutation tests and for testing pairwise synchrony and precise ...
Johnson Daniel M DM Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The - - 2013
Spontaneous Ca(2+) release (SCR) from the sarcoplasmic reticulum can cause delayed afterdepolarizations and triggered activity, contributing to arrhythmogenesis during β-adrenergic stimulation. Excessive beat-to-beat variability of repolarization duration (BVR) is a proarrhythmic marker. Previous research has shown that BVR is increased during intense β-adrenergic stimulation, leading to SCR. We aimed to ...
Seo Jung Min - - 2012
PURPOSE: To prospectively assess the usefulness of diffusion-weighted magnetic resonance imaging (MRI) with background body signal suppression (DWIBS) at 3T for the preoperative evaluation of endometrial cancer. MATERIALS AND METHODS: Fifty-two consecutive patients with biopsy-proven endometrial cancer were examined with a 3T MR scanner, followed by a hysterectomy. MR examinations ...
Ntaios George - - 2012
BACKGROUND AND PURPOSE: To assess whether the combined analysis of all phase III trials of nonvitamin-K-antagonist (non-VKA) oral anticoagulants in patients with atrial fibrillation and previous stroke or transient ischemic attack shows a significant difference in efficacy or safety compared with warfarin. METHODS: We searched PubMed until May 31, 2012, ...
Bartelt Rebekah R RR Department of Microbiology, University of Iowa, Iowa City, IA, - - 2013
T cells are essential for the adaptive immune response to pathogens. However, dysfunctional T cell activity has been implicated in numerous diseases, including the failure of organ transplants, allergic reactions, asthma, autoimmune disorders, and coronary artery disease. T cell responses to pathogens require the induction of the primary activating receptor, ...
Khoury Michael - - 2012
Patients with severe right ventricular outflow tract obstruction in tetralogy of Fallot typically have right-to-left shunting, resulting in low pulmonary blood flow and cyanosis. Here we present the case of an infant with tetralogy of Fallot and severe pulmonary valve stenosis, complicated by systemic hypertension, the presence of which altered ...
Hassan Mohamed - - 2012
The perception of adipose tissue has changed considerably with the dramatic increase in the incidence of obesity and obesity-related comorbidities over the past 3 decades. Excess fat is no longer associated with wealth, but is instead recognized as a risk factor for many diseases. Adipose tissue is increasingly being identified ...
Aparecido-Ferreira Alex - - 2012
We propose a novel sloped dielectric geometry in graphene as a band engineering method for widening the depletion region and increasing the electrical rectification effect in graphene pn junctions. Enhanced current-rectification was achieved in a bilayer graphene with a sloped dielectric top gate and a normal back gate. A bias ...
Cain Nicholas - - 2012
Stimulus from the environment that guides behavior and informs decisions is encoded in the firing rates of neural populations. Neurons in the populations, however, do not spike independently: spike events are correlated from cell to cell. To what degree does this apparent redundancy have an impact on the accuracy with ...
Pan Xing-Qing XQ College of Pharmacy, Ohio State University, Columbus, OH 43215, USA. - - 2012
M1-type macrophages are capable of inducing lysis in various types of cancer cells, but the mechanism of action is unclear. It has been noted that an "unknown protein" produced together with protease by activated macrophages is responsible for this action. Activated M1 macrophages have been recently reported to produce family ...
Pockrandt Daniel - - 2012
Gene-inactivation experiments have indicated that the putative prenyltransferase XptB from Aspergillus nidulans was likely to be responsible for the prenylation of 1,7-dihydroxy-6-methyl-8-hydroxymethylxanthone. Recently, it was suggested that this enzyme might also accept as substrate the benzophenone arugosin H, which is assumed to be a precursor of prenylated xanthones. In this ...
Bian Yong-Jun - - 2012
An efficient palladium-catalyzed CH functionalization of aldehydes with various N-substituted N-heteroarene-2-carboxamides has been developed for the synthesis of secondary imides. The reaction tolerates various functionalities, such as methoxy, fluoro, chloro, and bromo groups. A tentative radical mechanism for a Pd(II) /Pd(IV) catalytic cycle is proposed.
Pell Thomas P - - 2012
The crystal structures of bis-pyridine stabilized iodine dications [PhI(pyr)(2)](2+) are reported as triflate salts, representing the first ligand supported iodine dications to be structurally characterized. The pyridine complexes are susceptible to ligand exchange in reaction with stronger N-based donors such as 4-dimethylaminopyridine. Attempts to extend this reactivity to N-heterocyclic carbene ...
Zheng Yalin - - 2012
PURPOSE: To describe and evaluate an automated grading system for age-related macular degeneration (AMD) by color fundus photography. METHODS: An automated "disease / no disease" grading system for AMD was developed based on image mining techniques. First, image pre-processing was performed to normalize color and non-uniform illumination of the fundus ...
Szakiel Anna - - 2012
Analysis of the main triterpenoid profile of chloroform-soluble cuticular waxes of heather flowers and leaves by GC-MS revealed the following composition: five triterpene acids - betulinic, oleanolic, ursolic, 3-oxo-olean-12-en-28-oic and 3-oxo-ursan-12-en-28-oic; eight monohydroxyalcohols - α-amyrin, β-amyrin, cycloartanol, 24-methylenecycloartanol, friedelinol, germanicol, lupeol and taraxasterol; three dihydroxyalcohols - betulin, erythrodiol and uvaol; ...
Renault Hugues - - 2012
Environmental constraints challenge cell homeostasis and thus require a tight regulation of metabolic activity. We have previously reported that the γ-aminobutyric acid (GABA) metabolism is crucial for Arabidopsis salt tolerance as revealed by the NaCl hypersensitivity of the GABA transaminase (GABA-T, At3g22200) gaba-t/pop2-1 mutant. In this study we demonstrate that ...
Esfandiary Reza - - 2012
In addition to controlling typical instabilities such as physical and chemical degradations, understanding monoclonal antibodies' (mAbs) solution behavior is a key step in designing and developing process and formulation controls during their development. Reversible self-association (RSA), a unique solution property in which native, reversible oligomeric species are formed as a ...
Elze J - - 2012
SUMMARY The objective of this study was to identify the most reliable approach for prevalence estimation of Mycobacterium avium ssp. paratuberculosis (MAP) infection in clinically healthy slaughtered cattle. Sampling of macroscopically suspect tissue was compared to systematic sampling. Specimens of ileum, jejunum, mesenteric and caecal lymph nodes were examined for ...
Scalas L Francesca - - 2012
The individually importance-weighted average (IIWA) model posits that the contribution of specific areas of self-concept to global self-esteem varies systematically with the individual importance placed on each specific component. Although intuitively appealing, this model has weak empirical support; thus, within the framework of a substantive-methodological synergy, we propose a multiple-item ...
Wang Hong-Mei - - 2012
PURPOSE: We examine age- and sex-specific associations between weight status and intensity of cigarette smoking in a large sample of adolescents. Additionally, we test whether quality of life (QOL) and weight control behaviors (i.e., trying to lose, gain, or stay the same weight) mediate the association. METHODS: We used cross-sectional ...
Sharma Bhuey - - 2012
Over the past 120 years, the discipline of oncology has evolved so that a multitude of anatomical and increasingly complex functional imaging techniques are now applicable in both clinical and research platforms. This Timeline article revisits the achievements of the pioneer techniques in cancer imaging, discusses how these techniques have ...
Vaish Vivek - - 2012
Initiation of various cancers has been observed to be regulated via a prolonged inflammatory state in the tissues. However, molecular role of such a localized inflammation is not clear in the advanced stages of colorectal cancer. In this study, we have elaborated the role of various pro- and anti-inflammatory cytokines, ...
Busquet Perrine - - 2012
We investigated a possible drug efficacy enhancement obtained by combining inactive doses of galantamine and memantine in the scopolamine-induced amnesia model in mice. We evaluated the effects of the two drugs, either alone or in combination, using the spontaneous alternation and object recognition tasks. In both tests, combination of low ...
Giessen Clemens - - 2012
PURPOSE: To evaluate progression-free survival (PFS) as potential surrogate endpoint (SEP) for overall survival (OS) in metastatic colorectal cancer (mCRC) with focus on applicability to trials containing targeted therapy with anti-VEGF- or anti-EGFR directed monoclonal antibodies. Methods: A systematic literature search of randomized trials of first-line chemotherapy for mCRC reported ...
Qiao Yanbin - - 2012
Purpose. To investigate the effects of Sphingosine-1-phosphate (S1P) on the production of inflammatory mediators and the signaling pathways involved in S1P mediated production of cytokines by ARPE-19 cells. Methods. Expression of S1P receptors was examined using RT-PCR and real time PCR. ARPE-19 cells were stimulated with S1P or TNF-α, and ...
Waters Katrina M - - 2012
We previously established annexin A2 as a radioresponsive protein associated with anchorage independent growth in murine epidermal cells. In this study, we demonstrate annexin A2 nuclear translocation in human skin organotypic culture and murine epidermal cells after exposure to X radiation (10-200 cGy), supporting a conserved nuclear function for annexin ...
Brevers Damien - - 2012
Impaired insight into behavior may be one of the clinical characteristics of pathological gambling. In the present study, we tested whether the capacity to evaluate accurately the quality of one's own decisions during a non-gambling task was impaired in problem gamblers. Twenty-five problem gamblers and 25 matched healthy participants performed ...
Liu Yi - - 2012
To gain atomistic-level understanding on physical and chemical processes occurring at the interfaces of hypergolic propellants, we carried out the first reactive dynamic (ReaxFF) simulations to study the reactive hypergolic mixture of monomethylhydrazine (MMH) and dinitrogen tetroxide (NTO), in comparison with the ethanol (EtOH) and NTO mixture that is reactive ...
Zhang Kun - - 2012
Reduction of graphene oxide at the nanoscale is an attractive approach to graphene-based electronics. Here we use a platinum-coated atomic force microscope tip to locally catalyse the reduction of insulating graphene oxide in the presence of hydrogen. Nanoribbons with widths ranging from 20 to 80 nm and conductivities of >10(4) S m(-1) are ...
Jiang Yan - - 2012
The tribological behavior of graphene oxide (GO) films deposited on a mica substrate has been investigated by atomic force microscopy, in which different voltages were applied to a tip. It was found that the frictional forces on the GO films remain unchanged in the presence of negative tip voltages, while ...
Yu Heng-Yi - - 2012
Two new tetrahydrofuran lignans, schiglaucin A and B (1-2), together with eight known analogues (3-10), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic techniques (HRESIMS, UV, IR, NMR, and CD experiments). All of the compounds were tested for their neuroprotective ...
Mothi S N - - 2012
The term "Adolescence" literally means "to emerge" or "to attain identity" and is essentially the period of rapid physical and psychological development starting from the onset of puberty to complete growth. All adolescents go through a myriad of physical, psychological, neurobehavioural, hormonal and social developmental changes. Given the social taboos ...
Beaumont Elodie - - 2012
The development of a prophylactic vaccine against hepatitis C virus (HCV) has become an important medical priority, as three to four million new HCV infections are thought to occur each year worldwide. The hepatitis B virus (HBV) is another major human pathogen, but infections with this virus can be prevented ...
Gui T - - 2012
OBJECTIVE: The aims of this study are to summarize our experience of managing ovarian malignancy complicating pregnancy, to discuss the maternal and fetal outcomes, and to review the literature concerned. METHODS: Forty-one patients with ovarian malignancies complicating pregnancy at Peking Union Medical College Hospital between 1990 and 2012 were retrospectively ...
Versluis Maarten J - - 2012
PURPOSE: To determine the subjective experiences and the sources of discomfort for subjects undergoing 7 T magnetic resonance imaging (MRI) examinations on a whole-body 7 T system in a hospital setting MATERIALS AND METHODS: A postscan survey was filled out by 101 healthy subjects who participated in a 7 T ...
Topletz Ariel R AR School of Pharmacy, Department of Pharmaceutics, University of Washington, Seattle, WA 98195-7610, - - 2013
There is considerable evidence that drug disposition is altered during human pregnancy and based on probe drug studies, CYP2D6 activity increases during human pregnancy. The aim of this study was to determine whether the changes of CYP2D6 activity observed during human pregnancy could be replicated in the mouse, and explore ...
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