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Results 451 - 500 of 2028
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Ho Ming-Yi - - 2012
More effective treatments for metastatic lung cancer remain a pressing clinical need. In this study we identified MIG-7 protein as critical for COX-2/PGE2- and Akt/GSK-3β-dependent tumor invasion/metastasis. COX-2/PGE2 activated EP4 to enhance Akt and GSK-3β phosphorylation and β-catenin/LEF/TCF signaling leading to MIG-7 upregulation. RNAi-mediated attenuation of MIG-7 blocked COX-2/PGE2- and ...
Fukuda Tomokazu - - 2012
The hawksbill sea turtle (Eretmochelys imbricata) is a critically endangered species at a risk of extinction. Preservation of the genomic and cellular information of endangered animals is important for future genetic and biological studies. Here, we report the efficient establishment of primary fibroblast cultures from skin tissue of the hawksbill ...
Chen Shali - - 2012
PURPOSE: Diabetic retinopathy entails proliferation of vascular endothelial cells (ECs) and unregulated angiogenesis. We have previously shown that ECs increase the expression of an embryonic variant of fibronectin, called extra domain-B fibronectin (ED-B FN) in response to high glucose. We also showed that ED-B FN regulates EC tube morphogenesis possibly ...
Armaković Stevan - - 2012
In this article we focused on computational research of sumanenes disubstituted by boron where the two carbon atoms are substituted by two boron atoms. Disubstitution of rim carbon atoms with boron atoms significantly affected the geometry of the bowl. The main stability factors were used to determine the stability of ...
Lou Yanhong - - 2012
Cadmium (Cd) and lead (Pb) are regarded as the most toxic environmental pollutants because they are a threat not only to plants, but also to humans. Better understanding of the growth response, uptake and translocation of Cd and Pb in perennial ryegrass (Lolium perenne L.) would be helpful to evaluate ...
Wu Alex Man Lai - - 2012
The multidrug transporter, breast cancer resistance protein (BCRP, ABCG2), is upregulated in certain chemoresistant cancer cells and in the mammary gland during lactation. We investigated the role of the lactogenic hormone prolactin in the regulation of ABCG2. Prolactin dose-dependently induced ABCG2 in T-47D human breast cancer cells. This induction was ...
Cortés-González Jeff R - - 2012
Objective: To evaluate the efficacy of continuous intravesical irrigation with saline plus amikacin as adjuvant therapy and to evaluate the computed tomography (CT) scan in supine and prone positions (CystoCT scan) as an alternative diagnostic and evaluation method of intramural gas in emphysematous cystitis (EC) before and after treatment. Methods: ...
Karton Amir - - 2012
The enzyme myeloperoxidase generates significant amounts of hypochlorous acid (HOCl) at sites of inflammation to inflict oxidative damage upon invading pathogens. However, excessive production of this potent oxidant is associated with numerous inflammatory diseases. Recent kinetic measurements suggest that the endogenous antioxidant carnosine is an effective HOCl scavenger. On the ...
Micholt Evelien - - 2012
Embryonic cells are very robust in surviving dissection and culturing protocols and easily adapt to their in vitro environment. Despite these advantages, research in the olfactory field on cultured embryonic olfactory neurons is sparse. In this study, two primary rat olfactory explant cultures of different embryonic d (E17 and E20) ...
Wang Huan-Wen - - 2012
We report a remarkable transformation of multi-walled carbon nanotubes (MWCNTs) to curved graphene nanosheets (CGN) by a Hummers method. Through this simple process, MWCNTs can be cut and unzipped in the transverse and longitudinal direction, respectively. The as-obtained CGN possess the unique hybrid structure of 1D nanotube and 2D graphene. ...
Sarashina Akiko - - 2012
This randomized, placebo-controlled within dose groups, double-blind, single rising dose study investigated the safety, tolerability, pharmacokinetics and pharmacodynamics of 1 mg to 100 mg doses of empagliflozin in 48 healthy Japanese male subjects. Empagliflozin was rapidly absorbed, reaching peak levels in 1.25 to 2.50 hours; thereafter, plasma concentrations declined in ...
Pereira David Valter - - 2012
PURPOSE: This study evaluates the effects of the gold nanoparticle in endotoxin-induced uveitis in rats. METHODS: Adult male Wistar rats were divided into five groups: saline + saline, LPS + saline, LPS + prednisolone, LPS + gold salt (GS) and LPS + gold nanoparticle (GNP). Two hours after LPS administration, ...
D'Orsi Carl J - - 2012
Purpose:To compare stereoscopic digital mammography (DM) with standard DM for the rate of patient recall and the detection of cancer in a screening population at elevated risk for breast cancer.Materials and Methods:Starting in September 2004 and ending in December 2007, this prospective HIPAA-compliant, institutional review board-approved screening trial, with written ...
Ogiwara Ikuo - - 2012
Dravet syndrome is a severe form of epileptic encephalopathy characterized by early onset epileptic seizures followed by ataxia and cognitive decline. Approximately 80% of patients with Dravet syndrome have been associated with heterozygous mutations in SCN1A gene encoding voltage-gated sodium channel (VGSC) α(I) subunit, whereas a homozygous mutation (p.Arg125Cys) of ...
Arno Sally - - 2012
BACKGROUND:There is still little known regarding the effects of meniscus resection size on tibiofemoral stability. PURPOSE:To determine if partial medial meniscectomy of the posterior horn significantly alters tibiofemoral stability as measured by the anterior-posterior (AP) position and laxity of the medial femoral condyle. STUDY DESIGN:Controlled laboratory study. METHODS:Five cadaveric knees ...
Hu Youli - - 2012
Fibroblast growth factor (FGF) signaling is essential for both olfactory bulb (OB) morphogenesis and the specification, migration, and maturation of the GnRH-secreting neurons. Disruption of FGF signaling contributes to Kallmann syndrome characterized by both anosmia and sexual immaturity. However, several unanswered questions remain as to which specific FGF receptor (FGFR)-1 ...
Chakravadhanula Venkata Sai Kiran - - 2012
The morphology of nanocomposites plays a pivotal role in understanding their functionality and determines their capabilities for applications. The use of nanocomposite coatings requires a study of the size effects on their functional properties. Noble metal nanoparticles are promising candidates for nanocomposite thin film applications due to their antibacterial, plasmonic ...
Unubol Mustafa - - 2012
Acromegaly is a rare condition caused by a pituitary adenoma that secretes growth hormone. The mortality rate is 72 % higher in patients with acromegaly than in the general population according to meta-analyses. Mortality analysis has shown as many as 60 % of acromegalic patients die due to cardiovascular disease. Sudden cardiac ...
Wen Xiao-Dong - - 2012
The screened hybrid approximation (HSE) of density functional theory (DFT) is used to examine the structural, optical, and electronic properties of the high temperature phase, cubic UC(2). This phase contains C(2) units with a computed C-C distance of 1.443 Å which is in the range of a CC double bond; ...
Paschoal Diego - - 2012
In this paper, we assessed the quantum mechanical level of theory for prediction of linear and nonlinear optical (NLO) properties of push-pull organic molecules. The electric dipole moment (μ), mean polarizability ([Symbol: see text]α[Symbol: see text]) and total static first hyperpolarizability (β(t)) were calculated for a set of benzene, styrene, ...
Chen Xianzhong - - 2012
Surface topography and refractive index profile dictate the deterministic functionality of a lens. The polarity of most lenses reported so far, that is, either positive (convex) or negative (concave), depends on the curvatures of the interfaces. Here we experimentally demonstrate a counter-intuitive dual-polarity flat lens based on helicity-dependent phase discontinuities ...
Djamil John - - 2012
Carbon containing nano-sized molybdenum sulfide composites (MoS(x)C(y)) obtained by thermal decomposition reactions of (R(4)N)(2)MoS(4) (R = -H (C(0)), -CH(3) (C(1)), -C(3)H(7) (C(3)), and -C(6)H(13) (C(6))) show promising performance in visible-light driven photocatalytic hydrogen generation.
Badham Stephen P - - 2012
Criminal suspects with distinctive facial features, such as tattoos or bruising, may stand out in a police lineup. To prevent suspects from being unfairly identified on the basis of their distinctive feature, the police often manipulate lineup images to ensure that all of the members appear similar. Recent research shows ...
Hwang Heeyong - - 2012
CAPs off to the S-S bond: Application of a strategy involving the introduction of intramolecular disulfide bonds to amphipathic cationic antimicrobial peptides (CAPs) led to decreased α-helicity and hydrophobicity. The mutant peptides were observed to have significantly increased (250-fold) minimum hemolytic concentrations while maintaining MIC values against E. coli, affording more ...
Kolychev Eugene L - - 2012
Tris[3,5-bis(trifluoromethyl)phenyl]borane reacts with the sterically demanding Arduengo carbenes 1,3-di-tert-butylimidazolin-2-ylidene and 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene to form isolable normal adducts. In the case of 1,3-di-tert-butylimidazolin-2-ylidene, the adduct exhibits dynamic behaviour in solution and frustrated-Lewis-pair (FLP) reactivity. Fast cleavage of dihydrogen and THF, the CH activation of phenylacetylene, and carbon dioxide fixation were achieved by ...
Matuskova Miroslava - - 2012
BACKGROUND: Engineered mesenchymal stromal cells (MSC) were used in many preclinical studies of gene directed enzyme/prodrug therapy. We aimed to compare the efficacy of two most frequently used systems, and evaluate extent of bystander effect mediated by therapeutic MSC towards cell lines derived from different tumours. METHODS: Two approaches were ...
Huan Jianya - - 2012
Extrinsic signaling cues in the microenvironment of acute myeloid leukemia (AML) contribute to disease progression and therapy resistance. Yet it remains unknown how the bone marrow niche where AML arises is subverted to support leukemic persistence at the expense of homeostatic function. Exosomes are cell membrane-derived vesicles carrying protein and ...
Solimeo Renee L - - 2012
Regulatory agencies require testing of chemicals and products to protect workers and consumers from potential eye injury hazards. Animal screening, such as the rabbit Draize test, for potential environmental toxicants is time-consuming and costly. Therefore, virtual screening using computational models to tag potential ocular toxicants is attractive to toxicologists and ...
D'Ercole Loredana - - 2012
PURPOSE: To measure the maximum entrance skin dose (MESD) on patients undergoing carotid artery stenting (CAS) using embolic-protection devices, to analyze the dependence of dose and exposure parameters on anatomical, clinical, and technical factors affecting the procedure complexity, to obtain some local diagnostic reference levels (DRLs), and to evaluate whether ...
Laowansiri Utumporn - - 2012
Abstract Objective: To describe maxillary growth and maturation during infancy and early childhood. Materials and Methods: Serial cephalograms (N  =  210) of 30 subjects (15 females and 15 males) from the Bolton-Brush Growth Study were analyzed. Each subject had a series of six consecutive cephalograms taken between birth and 5 years ...
Yamamoto Manabu - - 2012
BACKGROUND: In the decade after the 1945 atomic bombing of Hiroshima, a high incidence of leukemia was observed among atomic bomb survivors. However, the incidence of other cancers gradually increased, while that of leukemia decreased after this period. We evaluated the clinical outcome of early gastric cancer and microsatellite stability ...
Otosaka Shigeyoshi - - 2012
Sedimentation and remobilization processes of radiocesium were investigated from time-series observations at nine stations in the coastal area of Ibaraki, 70-110 km south of the Fukushima Dai-ichi Nuclear Power Plant (1FNPP). Sediment samples were collected four times between June 2011 and January 2012, and concentrations of radiocesium as well as sediment ...
Millogo Athanase - - 2012
Purpose:  To estimate the lifetime prevalence of neurocysticercosis (NCC)-associated epilepsy and the proportion of NCC among people with epilepsy in three Burkina Faso villages. Methods:  Three villages were selected to represent three types of pig-rearing methods: (1) Batondo, where pigs are left to roam; (2) Pabré, where pigs are mostly ...
Tungen Jørn E - - 2012
Asymmetric iodolactonization of γ- and δ-unsaturated carboxylic acids has been explored in the presence of six different chiral organocatalysts 5-8. The catalyst 6b was found to facilitate the cyclization of 5-arylhex-5-enoic acids 1 to the corresponding iodolactones 2 with up to 96% ee. By this protocol, unsaturated carboxylic acids are ...
Huber Sabrina M - - 2012
Palladium-catalyzed hydrogenation of an octahedral zinc trans-ditriflate hemiporphyrazine "HpH(2)Zn(OTf)(2)" furnishes a new macrocycle "HpH(6)Zn(OTf)(2)". This reaction is fully reversible upon heating in nitrobenzene, and the conversion is easily monitored by changes in color and fluorescence properties. The reversible cycling between these molecules may find future applications in hemiporphyrazine-based catalysts and/or ...
Ybañez Adrian Patalinghug - - 2012
Anaplasma marginale is an etiologic agent of bovine anaplasmosis. This study aimed to molecularly detect and characterize A. marginale that is prevalent in Mongolian cattle populations. A highly specific and sensitive nested PCR (nPCR) method based on the Msp5 gene was developed to detect A. marginale (Msp5 nPCR). The method ...
Marimon Maria Paula C - - 2012
High fluoride concentrations (up to 11 mg/L) have been reported in the groundwater of the Guarani Aquifer System (Santa Maria Formation) in the central region of the state of Rio Grande do Sul, Southern Brazil. In this area, dental fluorosis is an endemic disease. This paper presents the geochemical data and ...
Jia Jin-Liang - - 2012
Nearly monodisperse Au nanorods (NRs) with different aspect ratios were separated from home-synthesized polydisperse samples using a gradient centrifugation method. The morphology, size and its distribution, and photo-absorption property were analyzed by transmission electron microscopy, atomic force microscopy and UV-visible spectroscopy. Subsequently, using colloidal Au NRs (36.2 nm ×10.7 nm) with 97.4% ...
Parish Leslie D - - 2012
A 31-year-old man presented with acute left hemiplegia. History revealed a tuberculous pneumonia partially treated 10 months before, and headache and left leg jerks occurring recently. Upon examination, he was drowsy, with rightward gaze and head deviation and left hemiplegia. MRI showed an infarct on the right anterior and middle ...
Tang Ada - - 2012
Objective: Community exercise programs are effective in improving aerobic capacity after stroke, but individual variability in training responses has not previously been studied. This study examined explanatory factors for post-program responses in aerobic capacity (VO2peak) with respect to training parameters and participant characteristics. Design: Secondary analysis of data from a ...
Levy Ophir - - 2012
Carbyne radicals: Reactions of trihaloalkyl compounds with Cr(2+) or V(2+) in aqueous solutions yield alkynes and other products. Stepwise halogen abstractions from the trihaloalkyls form alkyl carbyne triradicals in solution. These radicals undergo coupling reaction producing triply bonded alkyne molecules. This process is not metal-assisted and does not occur in ...
Monjardino Teresa - - 2012
OBJECTIVE: To quantify short- and long-term associations between dietary patterns defined a priori and bone mineral density (BMD) during adolescence. DESIGN: Dietary patterns were defined at 13 years old using a Mediterranean diet (MD) quality index, the Dietary Approaches to Stop Hypertension (DASH) diet index and the Oslo Health Study ...
Hassan Mohamed - - 2012
The perception of adipose tissue has changed considerably with the dramatic increase in the incidence of obesity and obesity-related comorbidities over the past 3 decades. Excess fat is no longer associated with wealth, but is instead recognized as a risk factor for many diseases. Adipose tissue is increasingly being identified ...
Aparecido-Ferreira Alex - - 2012
We propose a novel sloped dielectric geometry in graphene as a band engineering method for widening the depletion region and increasing the electrical rectification effect in graphene pn junctions. Enhanced current-rectification was achieved in a bilayer graphene with a sloped dielectric top gate and a normal back gate. A bias ...
Cain Nicholas - - 2012
Stimulus from the environment that guides behavior and informs decisions is encoded in the firing rates of neural populations. Neurons in the populations, however, do not spike independently: spike events are correlated from cell to cell. To what degree does this apparent redundancy have an impact on the accuracy with ...
Pockrandt Daniel - - 2012
Gene-inactivation experiments have indicated that the putative prenyltransferase XptB from Aspergillus nidulans was likely to be responsible for the prenylation of 1,7-dihydroxy-6-methyl-8-hydroxymethylxanthone. Recently, it was suggested that this enzyme might also accept as substrate the benzophenone arugosin H, which is assumed to be a precursor of prenylated xanthones. In this ...
Bian Yong-Jun - - 2012
An efficient palladium-catalyzed CH functionalization of aldehydes with various N-substituted N-heteroarene-2-carboxamides has been developed for the synthesis of secondary imides. The reaction tolerates various functionalities, such as methoxy, fluoro, chloro, and bromo groups. A tentative radical mechanism for a Pd(II) /Pd(IV) catalytic cycle is proposed.
Pell Thomas P - - 2012
The crystal structures of bis-pyridine stabilized iodine dications [PhI(pyr)(2)](2+) are reported as triflate salts, representing the first ligand supported iodine dications to be structurally characterized. The pyridine complexes are susceptible to ligand exchange in reaction with stronger N-based donors such as 4-dimethylaminopyridine. Attempts to extend this reactivity to N-heterocyclic carbene ...
Laurencin Mathieu - - 2012
de novo cyclic pseudopeptides composed of α-amino and aza-β3-amino acids were designed with the aim to obtain potential new antimicrobial agents. Antimicrobial Cyclic PseudoPeptides (ACPPs) are based on the properties of Antimicrobial Peptides (AMPs), so they are cationic and amphiphilic. Aza-β3-amino acids enhance the in vivo half-life of these compounds ...
Yang Qiong - - 2012
Alterations in the methylation of promoters of cancer-related genes are promising biomarkers for the early detection of disease. Compared with single methylation alteration, assessing combined methylation alterations can provide higher association with specific cancer. Here we use cationic conjugated polymer-based fluorescence resonance energy transfer to quantitatively analyse DNA methylation levels ...
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