Search Results
Results 1 - 50 of 2431
1 2 3 4 5 6 7 8 9 10 >
Lin E E Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, - - 2013
We previously reported improved body composition and cardiovascular risk markers plus a small decrease in glucose tolerance with GH administration vs placebo for 6 months to abdominally obese premenopausal women. The objective of this study was to determine whether the effects of GH treatment on cardiovascular risk markers, body composition ...
Turtle Emma J EJ Queen's Medical Research Institute, University of Edinburgh/BHF Centre for Cardiovascular Science, Edinburgh, EH16 4TJ, UK. - - 2013
To review current evidence on the effect of paracetamol on blood pressure (BP), the quality of the previous studies and the validity of the results, and to summarize these findings. A systematic literature review was performed by searching PubMed, the Cochrane library and EMBASE for publications between the years 1963 ...
Parajuli Shankar P SP Department of Pharmaceutical & Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, - - 2013
Overactive bladder (OAB) is often associated with abnormally increased detrusor smooth muscle (DSM) contractions. We used NS309, a selective and potent opener of the small or intermediate conductance Ca(2+) -activated K(+) (SK or IK, respectively) channels, to evaluate how SK/IK channel activation modulates DSM function. We employed single-cell RT-PCR, immunocytochemistry, ...
Zhang Min-Min MM Department of Biology, University of Utah, Salt Lake City, UT, - - 2013
Voltage-gated sodium channels (VGSCs) are assembled from two classes of subunits, a pore-bearing α-subunit (NaV 1) and one or two accessory β-subunits (NaV βs). Neurons in mammals can express one or more of seven isoforms of NaV 1 and one or more of four isoforms of NaV β. The peptide ...
Schmidt J A JA Department of Bioscience, AstraZeneca R&D Charnwood, Loughborough, Leicestershire, - - 2013
The discovery of DP2 as a second receptor for PGD2 has prompted the search for antagonists as potential novel therapies based on the associations between PGD2 and disease. Here we describe the biochemical and pharmacological properties of 4-(acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid (AZD1981), a novel DP2 receptor antagonist. Binding to DP2 , functional ...
Guan S P SP Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, - - 2013
Cigarette smoke is a major cause for chronic obstructive pulmonary disease (COPD). Andrographolide is an active biomolecule isolated from the plant Andrographis paniculata. Andrographolide has been shown to activate nuclear factor erythroid-2-related factor 2 (Nrf2), a redox-sensitive antioxidant transcription factor. As Nrf2 activity is reduced in COPD, we hypothesize that ...
Kim Tae Hyun TH College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, - - 2013
Oltipraz, a cancer chemopreventive agent, has an anti-steatotic effect via liver X receptor-α (LXRα) inhibition. Here we have assessed the biological activity of a major metabolite of oltipraz (M2) against liver steatosis and steatohepatitis and the underlying mechanism(s). Blood biochemistry and histopathology were assessed in high-fat diet (HFD)-fed mice treated ...
Cardamone L L Department of Medicine (RMH), University of Melbourne, Melbourne, Victoria, - - 2013
There is a high incidence of psychiatric comorbidity in people with epilepsy (PWE), particularly depression. The manifold adverse consequences of comorbid depression have been more clearly mapped in recent years. Accordingly, considerable efforts have been made to improve detection and diagnosis, with the result that many PWE are treated with ...
Ai Shibin S Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, - - 2013
Induction of multidrug resistance by doxorubicin (DOX), together with non-specific toxicities, has restricted DOX-based chemotherapy. Recently, we demonstrated that DOX conjugated with an EGF receptor-binding peptide (DOX-EBP) had enhanced anticancer efficacy and reduced systemic toxicity when targeting EGF receptor-overexpressing tumours. Here we investigated whether DOX-EBP is able to overcome drug ...
Kaur Sukhwinder S Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, - - 2013
Pancreatic diseases pose significant diagnostic challenge as signs and symptoms often overlap. We investigated the potential of pancreatic juice neutrophil gelatinase-associated lipocalin, macrophage inhibitory cytokine 1 (MIC-1), and carbohydrate antigen 19-9 (CA19-9) to aid in the diagnosis of patients with symptoms suggestive of pancreatic diseases. A total of 105 chronic ...
Henriksson Johanna T JT Texas Eye Research and Technology Center, University of Houston College of Optometry, Houston, TX 77204-2020, USA. - - 2013
To investigate the normal palpebral conjunctival histology in C57BL/6 mice and the structural changes that occur in a dry eye model. Twenty-four male and female C57BL/6 mice, 8 untreated and 16 exposed to experimental ocular surface desiccating stress (DS). Ocular dryness was induced by administration of scopolamine hydrobromide (0.5 mg/0.2 ...
Onat Filiz F Department of Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey. - - 2013
This commentary discusses the importance of a new study entitled 'ONO-2506 inhibits spike-wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation' by Yamamura et al. () from Dr Okada's laboratory. The results from this study suggest that specific astrocyte modulating approaches should be developed ...
Bellin Melena D MD Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN 55455, USA. - - 2013
Islet autotransplantation (IAT) is performed in nondiabetic patients with chronic pancreatitis at the time of total pancreatectomy (TP) to minimize risk of postoperative diabetes. The role of TP-IAT in patients with chronic pancreatitis and C-peptide-positive diabetes is not established. We postulate that IAT can preserve beta cell mass and thereby ...
Qin Xin X Calhoun Cardiology Center, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, - - 2013
Transient receptor potential melastatin 7 (TRPM7) is a unique channel kinase which is crucial for various physiological functions. However, the mechanism by which TRPM7 is gated and modulated is not fully understood. To better understand how modulation of TRPM7 may impact biological processes, we investigated if TRPM7 can be regulated ...
Bar-On Elhanan - - 2013
Following the 2010 earthquake in Haiti, the Israel Defense Forces Medical Corps deployed a field hospital in Port au Prince. The purpose of this study was to characterize the injuries sustained by the pediatric population treated in the hospital and examine the implications for planning deployment in future similar disasters. ...
Tianhang Luo - - 2013
It was observed that the number and function of endothelial progenitor cells (EPCs) decreased sharply in the progression of multiple organ dysfunction syndrome (MODS), and it may be the main pathogenesis for MODS. We aim to perform autologous transplantation of EPCs on animal models of MODS to investigate whether EPCs ...
Winer Leah L Department of Neurology, Washington University, St Louis, Missouri 63110, - - 2013
Therapies designed to decrease the level of SOD1 are currently in a clinical trial for patients with superoxide dismutase (SOD1)-linked familial amyotrophic lateral sclerosis (ALS). To determine whether the SOD1 protein in cerebral spinal fluid (CSF) may be a pharmacodynamic marker for antisense oligonucleotide therapy and a disease marker for ...
Ferraro Daniel J DJ Department of Radiation Oncology, Mallinckrodt Institute of Radiology, and Siteman Cancer Center, Washington University School of Medicine, 4511 Forest Park, Saint Louis, MO 63110, - - 2013
Phage-display peptide biopanning has been successfully used to identify cancer-targeting peptides in multiple models. For cancer-binding peptides, identification of the peptide receptor is necessary to demonstrate the mechanism of action and to further optimize specificity and target binding. The process of receptor identification can be slow and some peptides may ...
Olivares Carla N - - 2013
Endometriosis is a benign gynecological disease. Cyclooxygenase-2 (COX-2) and aromatase proteins have been shown to be overexpressed in eutopic endometrium from women suffering from this disease compared to disease-free women. Furthermore, inhibition of these molecules individually was demonstrated to have antiproliferative and proapoptotic effects both in vitro and in vivo ...
Oróstica María L - - 2013
Mating shut down a 2-methoxyestradiol (2ME) nongenomic action necessary to accelerate egg transport in the rat oviduct. Herein, we investigated whether tumour necrosis factor-α (TNF-α) participates in this mating effect. In unmated and mated rats, we determined the concentration of TNF-α in the oviductal fluid and the level of the ...
Hu Liwen - - 2013
Solar ultraviolet radiation (UVR) promotes pterygium and cataract development in the human eye. When outdoors, people are subject to varying ocular UVR exposure intensity depending on time of day and orientation to the sun. To assess this variability, a manikin eye was exposed to solar UVR at 12 rotation angles ...
Cranston Cory J - - 2013
Occupational and recreational noise exposures were evaluated at two sporting arenas hosting collegiate hockey games (Venue 1) and semi-professional hockey (Venue 2). A total of 54 personal noise dosimetry samples were taken over the course of seven home hockey games: 15 workers and 9 fans at Venue 1, and 19 ...
Romoser Matthew R E - - 2013
Older drivers are known to look less often for hazards when turning at T-intersections or at four way intersections. The present study is an extension of Romoser & Fisher (2009) and attempts to further analyze the differences in scanning behavior between older and experienced younger drivers in intersections. We evaluated ...
Flamme Gregory A - - 2013
The objectives of this study were to examine the prevalence of hearing loss in a sample of sports officials and estimate the duration of whistle use required to reach a permissible 8-hr 100% noise dose. We conducted an online survey of 321 sports officials regarding their exposure to whistle noise ...
Iyer Ramesh S - - 2013
Desmoplastic small-round-cell tumors are rare aggressive malignancies that belong to the "small round blue cell" tumor family. They predominantly affect the abdomen in adolescent and young adult males. Computed tomography is currently the modality of choice both for diagnosis and follow-up assessment. In this review, the authors provide a concise ...
Servaes Sabah - - 2013
Genitourinary imaging has evolved along with the ever improving technology, in addition, our pattern of referrals has changed, with most neonates being presently asymptomatic and their examinations being prompted by prenatally detected abnormalities. Ultrasonography dominates in this domain because of the combination of the excellent demonstration of anatomy, lack of ...
Syed Mohd Arif - - 2013
Imaging of the wrist is challenging to both radiologists and orthopedic surgeons. This is primarily because of the complex anatomy/functionality of the wrist and also the fact that many frequent injuries are sustained to the hands. On going developments in multidetector computed tomography (MDCT) technology with its "state of the ...
Kragh John F JF - - 2013
In 2008, we showed that incomplete or delayed extremity fasciotomies were associated with mortality and muscle necrosis in war casualties with limb injury. Subsequently, we developed an education program focused on surgeon knowledge gaps regarding the diagnosis of compartment syndrome and prophylactic fasciotomy. The program included educational alerts, classroom training, ...
Traino Heather M - - 2013
First Person Authorization (i.e., donor designation) legislation makes indicating one's intent to be a posthumous organ donor legally binding, much like a living will or advance directive. Such legislation is the most recent in a long history of organ donation policies in the United States and has received little attention ...
Myers Jeremy B - - 2013
We hypothesized that our compliance was low with recommended imaging for evaluation of traumatic bladder injury, which includes either a computed tomographic (CT) cystogram or plain cystogram. We sought to determine if poor compliance impacted diagnosis, management, and outcome of patients with bladder injury. Patients with bladder injury were identified ...
Singer Matthew B - - 2013
Little focus is on health care disparities in the elderly, a population largely covered by public insurance. We characterized insurance type and race in elderly trauma patients to determine if lack of insurance or minority status predict increased mortality. The National Trauma Data Bank (version 7.0) was queried for all ...
John Simon Mathew - - 2013
Abusive head injury is a major contributor to morbidity and mortality in infants and toddlers, but data comparing patterns of injury in corroborated accidental trauma and confessed child abuse are scarce. This is a retrospective review of head injuries with abnormal neuroimaging in children younger than 3 years during a ...
Khati Inès - - 2013
There are a few studies assessing repercussions in road accident victims, which reported their results in quality of life (QoL), on an epidemiologic point of view. ESPARR (follow-up of victims of road accident in the Rhône) is a prospective cohort study of 1,168 individuals (age ≥ 16 years) involved in ...
Power Robert A RA Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, England. - - 2013
It is unknown how genetic variants conferring liability to psychiatric disorders survive in the population despite strong negative selection. However, this is key to understanding their etiology and designing studies to identify risk variants. To examine the reproductive fitness of patients with schizophrenia and other psychiatric disorders vs their unaffected ...
Sulzer Jesse K JK Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112-1393, - - 2013
Acute alcohol intoxication (AAI) impairs the hemodynamic and arginine vasopressin (AVP) counter-regulation to hemorrhagic shock (HS) and lactated Ringer's solution (LR) fluid resuscitation (FR). The mechanism of AAI-induced suppression of AVP release in response to HS involves accentuated nitric oxide (NO) inhibitory tone. In contrast, AAI does not prevent AVP ...
Somnay Yash Y Endocrine Surgery Research Laboratories, Department of Surgery and University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, - - 2013
Carcinoids are neuroendocrine malignancies characterized by their overproduction of various bioactive hormones that lead to the carcinoid syndrome. We have shown previously that AKT serves as a key regulator of growth and phenotypic expression of tumor markers in carcinoids by the genetic depletion of AKT expression. However, no small-molecule inhibitor ...
Guo Cunlan C Single Molecule Study Laboratory, College of Engineering and Nanoscale Science and Engineering Center, University of Georgia, Athens, GA 30602, - - 2012
Heparin, a functionalized polysaccharide, is observed under a scanning tunneling microscope, which shows atomic scale conformational details. The peptide FX06 is found to bind to five consecutive sugar units of heparin and this interaction is directly revealed by atomic force microscopy and dynamic force spectroscopy measurements. The determined free energy ...
Torensma Ruurd R Department of Tumorimmunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. - - 2013
Bone marrow (BM) stromal cells (MSCs), also known as mesenchymal stem cells, display a high degree of heterogeneity. To shed light on the causes of this heterogeneity, MSCs were collected from either human BM (n=5) or adipose tissue (AT) (n=5), and expanded using 2 different culture methods: one based on ...
Tobiansky Daniel J - - 2012
Chemosensory stimulation is vital for the expression of rodent sexual behavior. As sexual activity decreases with aging, this study investigated whether aging also impacts the integration of sex-relevant chemosensory cues. To this end, several measures were obtained from adult (10-12 months) and aged (30-36 months) male rats after exposure to ...
Boehm M - - 2012
Photosystem II (PSII) mutants are useful experimental tools to trap potential intermediates involved in the assembly of the oxygen-evolving PSII complex. Here, we focus on the subunit composition of the RC47 assembly complex that accumulates in a psbC null mutant of the cyanobacterium Synechocystis sp. PCC 6803 unable to make ...
Rochaix Jean-David JD Departments of Molecular Biology and Plant Biology, University of Geneva, 30 Quai Ernest Ansermet, Geneva 4, Switzerland. - - 2012
Photosynthetic organisms are subjected to frequent changes in light quality and quantity and need to respond accordingly. These acclimatory processes are mediated to a large extent through thylakoid protein phosphorylation. Recently, two major thylakoid protein kinases have been identified and characterized. The Stt7/STN7 kinase is mainly involved in the phosphorylation ...
Jia Husen H Division of Plant Science, Research School of Biology, The Australian National University, Canberra, Australian Capital Territory 0200, - - 2012
Photosynthetic membrane sacs (thylakoids) of plants form granal stacks interconnected by non-stacked thylakoids, thereby being able to fine-tune (i) photosynthesis, (ii) photoprotection and (iii) acclimation to the environment. Growth in low light leads to the formation of large grana, which sometimes contain as many as 160 thylakoids. The net surface ...
Anderson Jan M JM Division of Plant Science, Research School of Biology, The Australian National University, Canberra, ACT 0200, Australia. - - 2012
The concept that the two photosystems of photosynthesis cooperate in series, immortalized in Hill and Bendall's Z scheme, was still a black box that defined neither the structural nor the molecular organization of the thylakoid membrane network into grana and stroma thylakoids. The differentiation of the continuous thylakoid membrane into ...
Horton Peter P Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, UK. - - 2012
The distinctive lateral organization of the protein complexes in the thylakoid membrane investigated by Jan Anderson and co-workers is dependent on the balance of various attractive and repulsive forces. Modulation of these forces allows critical physiological regulation of photosynthesis that provides efficient light-harvesting in limiting light but dissipation of excess ...
Matsubara Shizue S IBG-2: Pflanzenwissenschaften, Forschungszentrum Jülich, Jülich, - - 2012
Half a century of research into the physiology and biochemistry of sun-shade acclimation in diverse plants has provided reality checks for contemporary understanding of thylakoid membrane dynamics. This paper reviews recent insights into photosynthetic efficiency and photoprotection from studies of two xanthophyll cycles in old shade leaves from the inner ...
Barera Simone S Applied Science and Technology Department-BioSolar Laboratory, Politecnico di Torino, Viale T. Michel 5, Alessandria, - - 2012
It was the work of Jan Anderson, together with Keith Boardman, that showed it was possible to physically separate photosystem I (PSI) from photosystem II (PSII), and it was Jan Anderson who realized the importance of this work in terms of the fluid-mosaic model as applied to the thylakoid membrane. ...
Hasan S Saif SS Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, - - 2012
Lipid-binding sites and properties were compared in the hetero-oligomeric cytochrome (cyt) b(6)f and the yeast bc(1) complexes that function, respectively, in photosynthetic and respiratory electron transport. Seven lipid-binding sites in the monomeric unit of the dimeric cyanobacterial b(6)f complex overlap four sites in the Chlamydomonas reinhardtii algal b(6)f complex and ...
Chi Wei W Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, Beijing, People's Republic of - - 2012
Major multi-protein photosynthetic complexes, located in thylakoid membranes, are responsible for the capture of light and its conversion into chemical energy in oxygenic photosynthetic organisms. Although the structures and functions of these photosynthetic complexes have been explored, the molecular mechanisms underlying their assembly remain elusive. In this review, we summarize ...
Queval Guillaume G Centre for Plant Sciences, Faculty of Biology, University of Leeds, Leeds, - - 2012
Redox chemistry and redox regulation are central to the operation of photosynthesis and respiration. However, the roles of different oxidants and antioxidants in the regulation of photosynthetic or respiratory gene expression remain poorly understood. Leaf transcriptome profiles of a range of Arabidopsis thaliana genotypes that are deficient in either hydrogen ...
Anderson Jan M JM Division of Plant Science, Research School of Biology, The Australian National University, Canberra, Australian Capital Territory 0200, Australia. - - 2012
Long-term acclimation of shade versus sun plants modulates the composition, function and structural organization of the architecture of the thylakoid membrane network. Significantly, these changes in the macroscopic structural organization of shade and sun plant chloroplasts during long-term acclimation are also mimicked following rapid transitions in irradiance: reversible ultrastructural changes ...
1 2 3 4 5 6 7 8 9 10 >