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Results 401 - 450 of 2469
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Bauer Eileen M EM Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, - - 2013
In pulmonary hypertension the loss of precapillary arterioles results from vascular injury causing endothelial dysfunction. Endothelial cell migration and proliferation are critical for vascular regeneration. This study focused on the effect of high mobility group box 1 protein (HMGB1) on these critical processes. HMGB1 had no effect on human pulmonary ...
Moe S Jannicke - - 2012
Increased temperature and other environmental effects of global climate change (GCC) have documented impacts on many species (e.g., polar bears, amphibians, coral reefs) as well as on ecosystem processes and species interactions (e.g., the timing of predator-prey interactions). A challenge for ecotoxicologists is to predict how joint effects of climatic ...
Griffin Kevin L - - 2012
In 1953 Sir Hans Krebs won the Nobel prize for his classic work elucidating the metabolic steps by which citrate is metabolized within the mitochondria and drives energy recovery from stored carbohydrates. Through an elegant series of reactions fed from a common substrate, the tricarboxylic acid cycle (TCA) creates carbon ...
Henning Marcus A - - 2012
Background: There is ample evidence to suggest that academic dishonesty remains an area of concern and interest for academic and professional bodies. There is also burgeoning research in the area of moral reasoning and its relevance to the teaching of pharmacy and medicine. Aims: To explore the associations between self-reported ...
Bergeron Maxime - - 2012
The synthesis of monofluoroalkenes using an S(N)2' reaction of lithium amides derived from aromatic amines or lithium thiolates with 3,3-difluoropropenes is reported. This transformation features the use of fluoride as a leaving group.
Duan Xiaochuan - - 2012
In this study, we prepared high-stability hematite mesocrystals by a facile route without polymer additives. In particular, the rhombic hematite mesocrystals exhibit excellent lithium insertion behavior compared to the hematite single-crystals.
Poon Yi-Chieh - - 2012
Abstract Purpose: To evaluate the impact of macular serous retinal detachment (SRD) and its relationship to treatment outcome after primary intravitreal bevacizumab (IVB) injection in patients with branch retinal vein occlusion (BRVO) and macular edema (ME). Methods: Seventy-three patients with ME secondary to BRVO who received primary IVB (2.5 mg/0.1 mL) were ...
McEneny Jane - - 2013
The worldwide epidemic of obesity is a major public health concern and is persuasively linked to the rising prevalence of diabetes and cardiovascular disease. Obesity is often associated with an abnormal lipoprotein profile, which may be partly negated by pioglitazone intervention, as this can influence the composition and oxidation characteristics ...
Qu Yuan-Yuan - - 2013
This study aims to evaluate the potential value of patient characteristics in predicting overall survival (OS) in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with docetaxel-based thermotherapy. A total of 115 patients with mCRPC undergoing a docetaxel q3w regimen were enrolled in this study. A survival analysis was performed ...
Allman David A - - 2012
A 3 yr old spayed female boxer weighing 22.8 kg was presented for severe, acute vomiting and tenesmus. Tachycardia, tachypnea, dehydration, and abdominal pain were present on physical examination. Abdominal radiographs showed a foreign object (golf ball) in the fundus of the stomach, and a larger, round, soft-tissue opacity mass ...
Ray Herman E - - 2012
The single-arm, two-stage clinical trial is a popular design utilized to evaluate oncology treatments. The designs are typically augmented with an ad hoc toxicity monitoring rule that is imposed outside of the formal two-stage design. In this work, we present a flexible bivariate single-arm clinical trial design that incorporates both ...
Kuhn Alexandre - - 2012
ABSTRACT: BACKGROUND: Interpreting gene expression profiles obtained from heterogeneous samples can be difficult because bulk gene expression measures are not resolved to individual cell populations. We have recently devised Population-Specific Expression Analysis (PSEA), a statistical method that identifies individual cell types expressing genes of interest and achieves quantitative estimates of ...
Matthes-Martin S - - 2012
Human adenovirus (HAdV) infections are increasingly recognized as important pathogens in immunocompromised hosts, especially in patients with severely suppressed T-cell function. The 4th European Conference of Infections in Leukemia (ECIL-4) has developed evidence-based guidelines for diagnosis and management of HAdV infections. The risk for HAdV-associated disease is increased in children, ...
Huang Yin-Peng - - 2012
The aim of the present study is to evaluate the inhibitory effects of liver UDP-glucuronosyltransferases (UGTs) by glycyrrhizic acid and glycyrrhetinic acid, which are the bioactive ingredients isolated from licorice. The results showed that glycyrrhetinic acid exhibited stronger inhibition towards all the tested UGT isoforms, indicating that the deglycosylation process ...
Kougioumoutzi Evangelia - - 2012
Leaves show considerable variation in shape and can be described as simple, when the leaf is entire, or dissected, when the leaf is divided into individual leaflets. Here, we report that the SIMPLE LEAF3 (SIL3) gene is a novel determinant of leaf shape in Cardamine hirsuta - a dissected leafed ...
Santos Roberto P - - 2012
Palivizumab is a humanized monoclonal antibody used to decrease the threat of respiratory syncytial virus (RSV) infection among children at high risk. There are no standard guidelines due to conflicting data on palivizumab's use in the treatment of RSV lower respiratory tract infections. Intravenous (IV) palivizumab was shown to be ...
Kato Chika Nozaki - - 2012
The synthesis and crystal structure of a zirconocene derivative with α-Keggin mono-aluminum-substituted polyoxotungstate, [α-PW(11)Al(OH)O(39)ZrCp(2)](2)(6-) (Cp = C(5)H(5)(-)) (), which was obtained by the reaction of α-Keggin mono-aluminum-substituted polyoxotungstate with a biscyclopentadienylzirconium(iv) complex, is described herein. Analytically pure, homogeneous, yellow crystals of the tetra-n-butylammonium salt of polyoxoanion , [(n-C(4)H(9))(4)N](6)[α-PW(11)Al(OH)O(39)ZrCp(2)](2) (), were ...
Pataky Z - - 2012
In obesity, a dysregulation of the endocannabinoid system has been shown. The endocannabinoid receptor blockage by rimonabant demonstrated interesting metabolic effects. However, the role of rimonabant in weight loss of patients with binge eating disorder has not been investigated. Thus, our aim was to evaluate the effects of rimonabant on ...
Goto Tsuyoshi - - 2012
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that regulates the expression of the genes involved in fatty acid oxidation. PPARα activators induce fatty acid oxidation in the liver, thereby improving lipid and carbohydrate metabolism in obese mice. In this study, the dietary cis-carotenoids, bixin and norbixin, which ...
Vazquez José A - - 2012
Abstract Objectives: The aim of this prospective phase II, randomized, investigator-blinded study (NCT00690378) was to compare the efficacy and safety of ceftazidime-avibactam and imipenem-cilastatin in hospitalized adults with serious complicated urinary tract infection (cUTI) due to Gram-negative pathogens. Patients and methods: Patients aged between 18 and 90 years with cUTI ...
Limnell Katriina - - 2012
Background and aims: The purpose of the present cross-sectional study was to analyze how knee replacement affects performance in activities of daily living (ADL), mobility, and pain in older patients with knee osteoarthritis. Methods: Knee osteoarthritis patients aged ≥ 75 years scheduled for knee replacement (Group 0, n=68), or having ...
Brunberg Emma - - 2012
Knowledge about gene expression in animals involved in abnormal behaviours can contribute to understanding of the underlying biological mechanisms. The present study aimed to explore the motivational background to tail biting, an abnormal injurious behavior and severe welfare problem in pig production. Affymetrix microarrays were used to investigate gene expression ...
Harris E K - - 2012
Yorkshire gilts either remained in their individual stall from d 40 to term (CON; n = 7), or were subjected to exercise for 30 min 3 times per week from mid to late gestation (EX; n = 7) to determine the impact of increased maternal activity during gestation on maternal ...
Morra Marco - - 2012
Abstract Osteoimmunology, i.e. the cross-talk between cells from the immuno and skeletal systems, suggests a role of pro-inflammatory cytokines in the stimulation of osteoclasts activity. Endotoxin or bacterial challenges to inflammatory cells are directly relevant to dental implants pathologies involving bone resorption, such as osteointegration failure and periimplantitis. While the ...
Garcia-Portilla M P - - 2012
AIMS: To update and summarise the scientific knowledge on the long-term outcomes of the different pharmacological treatment options for opioid dependence currently available and to provide a critical discussion on the different treatment options based on these results. METHODS: We performed a literature search using the PubMed databases and the ...
Chaze Thibault T Institut de Radioprotection et de Sûreté Nucléaire (IRSN), DRPH, SRBE, LRTE, 92260 Fontenay-aux-Roses, - - 2013
Exposure of the skin to ionizing radiation leads to characteristic reactions that will often turn into a pathophysiological process called the cutaneous radiation syndrome. The study of this disorder is crucial to finding diagnostic and prognostic bioindicators of local radiation exposure or radiation effects. It is known that irradiation alters ...
Port John D - - 2012
PURPOSE: (i) To develop an MRS technique to measure (7) Li levels in human brain in a reasonable scan time, (ii) to develop a technique to quantify (7) Li T2 relaxation times as measured from human brain in patients taking lithium for the treatment of their bipolar disorder, and (iii) ...
Zilberberg Liat - - 2012
The growth mechanism of TiO2 films and their morphology are reported using Reactive Layer Assisted Deposition (RLAD) method under ultra high vacuum conditions. The oxide film formation involves Ti atoms deposition on top of amorphous solid water (ASW) condensed on a SiO2/Si(100) support at 90K. Subsequent annealing leads to desorption ...
Ujiie Hideyuki - - 2012
Congenital molluscum contagiosum is rare but has been reported previously. We present a unique case of linear congenital molluscum on the coccygeal region. To make a correct diagnosis, avoid unnecessary examination, and start appropriate treatment as soon as possible, it is beneficial for dermatologists to be aware that molluscum contagiosum ...
Jonsdottir Olof H - - 2012
To increase knowledge on iron status and growth during the first 6 months of life. We hypothesized that iron status would be better in infants who received complementary foods in addition to breast milk compared with those exclusively breastfed. One hundred nineteen healthy term (≥37 weeks) singleton infants were randomly ...
Gajic-Veljic Mirjana - - 2012
Granulomatosis with polyangiitis (GPA), also known as Wegener's granulomatosis, is a rare disease in childhood. Of 39 GPA patients that we diagnosed during a 20-year period, only 3 (7.7%) were younger than 18 years. We report the course of GPA in three girls whose disease started at the ages of ...
Fukaya Shinji - - 2012
TNF-α-converting enzyme (TACE) can cleave transmembrane proteins, such as TNF-α, TNF receptors, and epidermal growth factor receptor (EGFR) ligands, to release the extracellular domains from the cell surface. Recent studies have suggested that overexpression of TACE may be associated with the pathogenesis of inflammation and fibrosis. To determine the roles ...
Makeyev Aleksandr V - - 2012
Objectives :  GTF2I and GTF2IRD1 genes located in Williams-Beuren syndrome (WBS) critical region encode TFII-I family transcription factors. The aim of this study was to map genomic sites bound by these proteins across promoter regions of developmental regulators associated with craniofacial development. Design :  Chromatin was isolated from human neural ...
Muraoka Takahiro - - 2012
A multiblock amphiphilic molecule 1, with a tetrameric alternating sequence of hydrophilic and hydrophobic units, adopts a folded structure in a liposomal membrane like a multipass transmembrane proteins, and is able to transport alkali metal cations through the membrane. Hill's analysis and conductance measurements, analyzed by the Hille equation, revealed ...
Bressani V O - - 2012
Dermatophytes invade the stratum corneum of the skin and other keratinized tissues such as hair and nails, and Trichophyton rubrum causes approximately 80% of cutaneous mycoses in humans. To evaluate the cellular immune response of patients with extensive dermatophytosis caused by T. rubrum, we evaluated lymphocyte populations, the lymphoproliferative response ...
Murphy R M RM Department of Zoology, La Trobe University, Melbourne, Victoria 3086, - - 2013
Excessive increases in intracellular [Ca(2+)] in skeletal muscle fibres cause failure of excitation-contraction coupling by disrupting communication between the dihydropyridine receptors in the transverse tubular system and the Ca(2+) release channels (RyRs) in the sarcoplasmic reticulum (SR), but the exact mechanism is unknown. Previous work suggested a possible role of ...
Schmidt Anja - - 2012
In flowering plants, double fertilization of the female gametes, the egg and central cell, initiates seed development to give rise to a diploid embryo and the triploid endosperm. In the absence of fertilization, the MEA-FIE Polycomb Repressive Complex 2 (PRC2) represses this developmental process by histone methylation of certain target ...
Ziarek Joshua J JJ Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, - - 2013
The ability to interact with cell surface glycosaminoglycans (GAGs) is essential to the cell migration properties of chemokines, but association with soluble GAGs induces the oligomerization of most chemokines including CXCL12. Monomeric CXCL12, but not dimeric CXCL12, is cardioprotective in a number of experimental models of cardiac ischemia. We found ...
Schenzel Judith - - 2012
Mycotoxins are secondary metabolites that are naturally produced by fungi which infest and contaminate agricultural crops and commodities (e.g., small grain cereals, fruits, vegetables, and organic soil material). Although these compounds have extensively been studied in food and feed, only little is known about their environmental fate. Therefore, we investigated ...
Kazak Alexandr Vasilevich - - 2012
In order to study the influence of structure peculiarities of porphyrin derivatives on their supramolecular organization in thin films, 15 new meso-substituted tetraphenylporphyrin derivatives and their metal complexes with substituents (-OC4H9 or -OC16H33) in para- or ortho-positions were studied. The films of the studied compounds were obtained by Langmuir-Schaefer method. ...
Lancuski Anica - - 2012
This paper reports highly surface functionalized and 'clickable' α,ω-azido-poly(ε-caprolactone) fibers (f-PCL-N3), obtained by classical electrospinning setup. Azide-functionalized PCL was obtained from a commercially available α,ω-poly(ε-caprolactone)-diol, PCL2, and electrospun with a non-derivative high molecular weight PCL. Successful chemical modifications of PCL2 were confirmed by NMR, FTIR and MALDI-TOF mass spectroscopy. High ...
Behrens R R Physikalisch-Technische Bundesanstalt, Bundesallee 100, D-38116 Braunschweig, Germany. - - 2012
In the past the operational quantity H(p)(3) has been defined for calibration purposes in a slab phantom. Recently, an additional phantom in the form of a cylinder was suggested for eye lens dosimetry as a cylinder much better approximates the shape of a head than a slab. Therefore, this work ...
Di Cagno Alessandra - - 2012
In the angiotensin-converting enzyme (ACE) gene, Alu deletion, in intron 16, is associated with higher concentrations of ACE serum activity and this may be associated with elite sprint and power performance. The Alu insertion is associated with lower ACE levels and this could lead to endurance performance. Moreover, recent studies ...
Rullaud Vanessa - - 2012
An amphiphilic calix[4]arene derivative bearing four guanidino moieties at the upper rim and four dodecyl chains at the lower rim was shown to form stable solid lipid nanoparticles (SLNs) in water. The study of the interactions of these cationic SLNs with DNA revealed a sequence-dependent groove binding mechanism.
McDaniel Kristin A - - 2012
  Peanuts in North America and Europe are primarily consumed after dry roasting. Standard industry practice is to roast peanuts to a specific surface color (Hunter L-value) for a given application; however, equivalent surface colors can be attained using different roast temperature/time combinations, which could affect product quality. To investigate ...
Domingo Victoriano - - 2012
The first synthesis of (+)-myrrhanol C (), an antitumor polypodane-type bicyclic triterpene with inhibitory activity against androgen insensitive prostate cancers, is reported herein (IC(50) 10 μmolar). A key step in our convergent synthesis of (+)-myrrhanol C and related analogues is the employment of a microbial stereo- and regioselective late stage ...
Patel Kashyap - - 2013
Murine models are used to study erythrocytic stages of malaria infection, because parasite morphology and development are comparable to those in human malaria infections. Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) models for antimalarials are scarce, despite their potential to optimize antimalarial combination therapy. The aim of this study was to develop a mechanism-based ...
Britton Edward - - 2012
The goal of this brief review is to address the role of the ageing gut in the genesis of malnutrition in the elderly. We assess the burden of malnutrition in the elderly, exploring the role of comorbid conditions and neurohumoral changes that take place to contribute towards the process of ...
Koloren Zeynep - - 2012
Abstract The aim of this study was to evaluate Cryptosporidium spp. contamination of sea and tap water samples from the Sinop and Ordu Provinces, Black Sea, Turkey. The samples (10 L) were collected in spring, summer, autumn, and winter in 2011. A total of 128 water samples was analyzed using ...
Gil de Pertierra Alicia Alida - - 2012
Abstract The proteocephalidean cestode Harriscolex nathaliae n. sp. (Proteocephalidae: Zygobothriinae) is described from the intestine of the spotted sorubim Pseudoplatystoma corruscans (Spix & Agassiz) (Siluriformes: Pimelodidae) from the Paraná River basin in Argentina. This new species differs from the only species of the genus, Harriscolex kaparari (Woodland, 1935), which is ...
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