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Results 301 - 350 of 2469
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Chaplin Emma Jane Louise - - 2012
BACKGROUND: Neuromuscular electrical stimulation (NMES) has shown to improve skeletal muscle strength and exercise capacity in stable patients with chronic obstructive pulmonary disease (COPD). Variations in NMES protocols are considerable. We aimed to compare changes in muscle strength after high-frequency and low-frequency NMES in patients admitted to hospital with an ...
Hazra Soumitra - - 2012
Berberine, palmatine and coralyne, the isoquinoline alkaloids distributed in many botanical families, are extensively investigated due to their potential therapeutic actions and clinical utilities. In this work, their binding characteristics to hemoglobin (Hb) were studied by UV-vis absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy, isothermal calorimetric titration and differential scanning ...
McMahan Zsuzsanna H - - 2012
The management of patients with systemic sclerosis (SSc) can be challenging because disease-associated damage is often difficult to reverse and curative therapies are not yet available. Early identification and appropriate monitoring of patients with SSc is, therefore, critical so that active disease can be controlled and tissue damage prevented or ...
Sadr-Azodi O - - 2012
OBJECTIVES:Previous research has indicated that obesity may be linked to the severity of acute pancreatitis. However, the association between abdominal and total adiposity as risk factors in the development of acute pancreatitis in a general population has not been studied.METHODS:A follow-up study was conducted, using the Swedish Mammography Cohort and ...
Knapp Caroline M - - 2012
Reaction of an ethylenediamine solution of K(3)As(7) with the low-valent, low-coordinate cobalt(ii) complex [Co(mes)(2)(PEt(2)Ph)(2)] yielded the novel dianionic species [Co(η(3)-As(3)){η(4)-As(4)(mes)(2)}](2-) (1). The [η(4)-As(4)(mes)(2)](2-) moiety present in 1 is a rare example of a group 15 analogue of a butadienediide.
Liu Xingping X Department of Biomedical Engineering, University of California, Irvine, California 92697, - - 2013
Continuum solvent treatments based on the Poisson-Boltzmann equation have been widely accepted for energetic analysis of biomolecular systems. In these approaches, the molecular solute is treated as a low dielectric region and the solvent is treated as a high dielectric continuum. The existence of a sharp dielectric jump at the ...
Varela Luis L Program in Integrative Cell Signalling & Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, - - 2012
With the steady rise in the prevalence of obesity and its associated diseases, research aimed at understanding the mechanisms that regulate and control whole body energy homeostasis has gained new interest. Leptin and insulin, two anorectic hormones, have key roles in the regulation of body weight and energy homeostasis, as ...
Bi Sai - - 2012
An ultrasensitive and highly selective method for polymerase chain reaction-free (PCR-free) messenger RNA (mRNA) expression profiling is developed through a novel cross-rolling circle amplification (C-RCA) process based on DNA-rotaxane nanostructures. Two species of DNA pseudorotaxane (DPR) superstructures (DPR-I and DPR-II) are assembled by threading a linear DNA rod through a ...
Saar Matthias - - 2012
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: There is evidence from large abdominal surgeries and some open cystectomy series that multifactorial fast-track regimens shorten postoperative convalescence without any effect on morbidity and mortality. Such a regimen is of particular interest in combination with minimally invasive techniques, ...
Weiss Günter - - 2012
Anaemia is frequently observed in patients with inflammatory rheumatic diseases. Depending on its severity, anaemia negatively affects cardiovascular performance, physical activity and the quality of life of patients. However, anaemia is considered to be a symptom of the underlying inflammatory disease and, thus, neglected as a complex medical condition that ...
Qi Peng P National Key Laboratory of Plant Molecular Genetics and National Center for Plant Gene Research (Shanghai), Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, - - 2012
Increased crop yields are required to support rapid population growth worldwide. Grain weight is a key component of rice yield, but the underlying molecular mechanisms that control it remain elusive. Here, we report the cloning and characterization of a new quantitative trait locus (QTL) for the control of rice grain ...
Burr Stephen P SP Regulatory T Cell Laboratory, Department of Veterinary Clinical Sciences, Royal Veterinary College, London, - - 2013
In recent years, mesenchymal stromal cells (MSCs) and regulatory T cells (Tregs) have both garnered significant interest from immunologists worldwide, not least because of the potential application of both cell types in the treatment of many chronic inflammatory and autoimmune diseases. Although both MSCs and Tregs can be considered immunosuppressive ...
Villanueva Augusto - - 2012
The management of hepatocellular carcinoma (HCC) has substantially changed in the past few decades. Improvements in patient stratification (for example, using the Barcelona Clinic Liver Cancer staging system) and the introduction of novel therapies (such as sorafenib) have improved patient survival. Nevertheless, HCC remains the third most common cause of ...
Berzigotti Annalisa - - 2012
OBJECTIVES:Cardiovascular risk factors (CVRF) lead to systemic endothelial dysfunction. It has been suggested that in cirrhosis, cardiovascular risk is low and systemic endothelial function is enhanced. However, there is no prospective study evaluating the relationship between cardiovascular risk and systemic endothelial function in cirrhosis, which was investigated here.METHODS:In 47 patients ...
Michel Jesse S - - 2012
This study examines the relative importance of individual differences in relation to perceptions of work-family conflict and facilitation, as well as the moderating role of boundary preference for segmentation on these relationships. Relative importance analyses, based on a diverse sample of 380 employees from the USA, revealed that individual differences ...
Mössinger Julia J Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 6, 14195 Berlin, - - 2012
Phosphatidylinositol (PI) 4-phosphate (PI(4)P) and its metabolizing enzymes serve important functions in cell signalling and membrane traffic. PI 4-kinase type IIα (PI4KIIα) regulates Wnt signalling, endosomal sorting of signalling receptors, and promotes adaptor protein recruitment to endosomes and the trans-Golgi network. Here we identify the E3 ubiquitin ligase Itch as ...
Akkoç Y - - 2012
Study design:Multi-center, cross-sectional study.Objectives:To investigate the effects of different bladder management methods on the quality of life (QoL) in patients with spinal cord injury (SCI).Setting:Turkey.Methods:Consecutive SCI patients (n=195, 74.4% males), for whom at least 6 months had elapsed since the injury, were included and evaluated in five groups: normal spontaneous ...
Folkesson Anders - - 2012
The airways of patients with cystic fibrosis (CF) are nearly always infected with many different microorganisms. This environment offers warm, humid and nutrient-rich conditions, but is also stressful owing to frequent antibiotic therapy and the host immune response. Pseudomonas aeruginosa is commonly isolated from the airways of patients with CF, ...
Morita Masato - - 2012
We present theoretical calculations on the vibrational spectra between the energy range of 2000-4000 cm(-1) for 4 isoenergetic conformers of gas phase OH(-)(H(2)O)(3) and OH(-)(H(2)O)(3)·Ar clusters. The peak positions and associated intensities of the OH stretching vibrations were calculated using an extended local mode model on multi-dimensional ab initio potential ...
Coron F - - 2012
OBJECTIVES: Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder with manifestations mainly involving the skeletal, ocular, and cardiovascular systems. The phenotypic variability observed in MFS makes genetic counselling difficult. Prenatal diagnosis (PND) and preimplantation genetic diagnosis are technically feasible when a causal mutation is identified, but both raise ...
Martis Vladimir - - 2012
In this paper, we report a detailed characterisation of chromium doped iron oxide catalysts using a range of techniques to establish the nature of chromium species in the near surface and bulk of iron oxide, high-temperature shift (HTS) catalysts. In particular we have employed X-ray absorption spectroscopy Cr K-edge near ...
Hoppe Berthold - - 2012
Activation of the immune system has been increasingly recognised to be associated with procoagulatory status in patients with inflammatory rheumatic disease. Changes in endothelial cell and platelet activation, blood flow, expression and activity of different coagulation factors, and impaired fibrinolysis serve as pathophysiological basis for enhanced risk of venous thromboembolism ...
Cotignola J - - 2012
Background:Organ confined prostate cancer (PCa) can be cured by radical retropubic prostatectomy (RRP); however, some tumors will still recur. Current tools fail to identify patients at risk of recurrence. Glutathione-S-transferases (GSTs) are involved in the metabolism of carcinogens, hormones and drugs. Thus, genetic polymorphisms that modify the GST activities may ...
Li Xiaoqing - - 2012
Sulfonyl radicals generated from sulfonylhydrazides by the Bu(4)NI-tert-butyl hydroperoxide (TBHP) catalysis system underwent addition to a variety of α-methyl styrene derivatives to give the corresponding allylic sulfones. This selective allylic sulfonylation is metal-free, operationally simple, and environmentally friendly.
Bessissow Talat - - 2012
OBJECTIVES:Endoscopic mucosal healing is a key endpoint for the treatment of ulcerative colitis (UC). The role of microscopic activity in predicting disease relapse has not been fully assessed. We aimed to investigate the predictive role of serologic and histologic markers on disease relapse in UC patients with endoscopically inactive disease.METHODS:Adult ...
Pomp Oz - - 2012
The ability to convert human somatic cells into induced pluripotent stem cells (iPSCs) is allowing the production of custom-tailored cells for drug discovery and for the study of disease phenotypes at the cellular and molecular level. IPSCs have been derived from patients suffering from a large variety of disorders with ...
Hagiwara M - - 2012
Background:Patients with bone metastases secondary to prostate cancer are predisposed to skeletal-related events (SREs), including spinal cord compression, pathological fracture, surgery to bone and radiotherapy to bone. The objective of this study was to document current patterns of healthcare utilization and costs of SREs in patients with prostate cancer and ...
Rogers J - - 2012
The corticotrophin-releasing hormone (CRH) system integrates the stress response and is associated with stress-related psychopathology. Previous reports have identified interactions between childhood trauma and sequence variation in the CRH receptor 1 gene (CRHR1) that increase risk for affective disorders. However, the underlying mechanisms that connect variation in CRHR1 to psychopathology ...
Kim Eric H - - 2012
What's known on the subject? and What does the study add? For patients who are unfit for extirpative surgery, percutaneous cryoablation (PCA) presents a minimally-invasive alternative for the treatment of renal masses. PCA has been demonstrated to be safe, with complication rates <10% being reported consistently. Studies have suggested that ...
Tan Amabel C L - - 2012
In this study, we examined the reactivity of human peripheral blood mononuclear cells to a panel of influenza A virus (IAV) CD8(+) T-cell epitopes that are recognised by the major human leukocyte antigen (HLA) groups represented in the human population. We examined the level of recognition in a sample of ...
Stock Amanda A Paediatric Emergency Physician, Royal Children's Hospital, Melbourne, Australia. - - 2013
To determine the prevalence of postnatal depression (PND) in mothers of young infants presenting to the emergency department (ED). Prospective observational study of the prevalence of PND in mothers of infants aged 14 days to 6 months presenting with non-time-critical conditions to the ED of a large tertiary paediatric hospital. ...
Peters S O - - 2012
Brangus heifers (i.e., 3/8 Brahman-Bos indicus x 5/8 Angus- Bos Taurus; n ≈ 800) heifers from 67 sires were used to estimate heritability and conduct a genome-wide association study (GWAS) for 2 binary fertility traits, first service conception (FSC) and heifer pregnancy (HPG). Genotypes were from 53,692 loci on the ...
Bottje W - - 2012
Understanding the cellular basis of feed efficiency (FE) is instrumental to helping poultry and livestock industries continue to provide high quality protein for an increasingly crowded world. To understand relationships of FE and gene expression, global RNA transcription was investigated in breast muscle obtained from a male broiler line fed ...
Abdulrahman Basant A BA Department of Microbial Infection and Immunity, Ohio State University, Columbus, Ohio 43210, - - 2013
Cystic fibrosis is the most common inherited lethal disease in Caucasians. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), of which the cftr ΔF508 mutation is the most common. ΔF508 macrophages are intrinsically defective in autophagy because of the sequestration of essential autophagy molecules within ...
Mukai Chisato - - 2012
The unprecedented Csp3-Csp3 bond cleavage of the unactivated cyclopentane has been achieved. The RhI-catalyzed cycloaddition of allenylcyclopentane-alkynes produced in situ the 9-cyclopentyl-8-rhodabicyclo[4.3.0]nona-1,6-diene intermediates, which were subsequently susceptible to the [7+2] cycloaddition via β-carbon elimination affording the bicyclo[7.4.0]tridecatriene derivatives in good yields. Changing the RhI catalyst effected the Cγ-H bond activation ...
Zhang Bingbo - - 2012
Quantum dots (QDs) have been widely used as fluorescent probes in cell-targeted imaging. However, nonspecific binding to cellular membranes has been a major challenge. In this study, a new approach is developed for effective reduction of nonspecific binding by bovine serum albumin (BSA)-coated QDs in cell targeting. The experimental results ...
Ackerman Ilana N - - 2012
Objective. To improve understanding of barriers to participation in community-based arthritis self-management programmes and patient preferences for self-management education.Methods. Individuals with hip or knee OA referred to orthopaedic surgeons or rheumatologists at six public and private hospitals in Victoria, Australia, were recruited for a randomized controlled trial (RCT) of the ...
Fishman Randy S - - 2012
The diruthenium compound [Ru(2)(O(2)CMe)(4)](3)[Cr(CN)(6)] contains two weakly coupled, ferrimagnetically ordered sublattices occupying the same volume. Due to the weak, antiferromagnetic dipolar interaction K(c) ≈ 5 × 10(-3) meV between sublattices, a small magnetic field H(c) ∼ K(c)/μ(B) ≈ 800 Oe aligns the sublattice moments. Powder neutron-diffraction measurements on a deuterated sample confirm an earlier prediction that the sublattice moments are ...
Euser Anja S - - 2012
One of the core features of individuals with a substance-use disorder (SUD) is the reduced ability to successfully process errors and monitor performance, as reflected by diminished error-related negativities (ERN). However, whether these error-related brain abnormalities are caused by chronic substance use or rather predates it remains unclear. The present ...
Ang Jocelyn Y JY Division of Infectious Diseases, Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI 48201, USA. - - 2012
The aim of this study was to investigate the effects of massage therapy (MT) on the immune system of preterm infants. The primary hypothesis was that MT compared with sham therapy (control) will enhance the immune system of stable premature infants by increasing the proportion of their natural killer (NK) ...
Mayrovitz Harvey N - - 2012
Abstract Background: Skin changes in diabetes mellitus (DM) include possible increases in foot skin water content as interpreted from altered echogenicity in high-frequency ultrasound images. The present goal was to investigate the possibility of undetected increased local skin water in persons with DM using a handheld portable rapid measuring device ...
Zou Duohong - - 2012
Abstract ABSTRACTThe aim of this study was to evaluate oral function rehabilitation in patients with hypohidrotic ectodermal dysplasia (HED) using implant-supported prostheses base on bone augmentation. From September 2005 and March 2009, twenty-five HED patients were chose to analyze clinical data in this study. The criteria for patient selection was ...
Packer Dominic J - - 2012
Not every situation affords the appropriate setting to articulate group problems, and I predicted that strongly identified members would be particularly sensitive to the intergroup context in which ingroup criticism is expressed. In Study 1, strongly but not weakly identified members reduced criticism of their ingroup when communicating with an ...
Kotsakis Georgios - - 2012
Abstract It has been documented that after every extraction of one or more teeth, the alveolar bone of the respective region undergoes resorption and atrophy. Therefore, ridge preservation techniques are often employed after tooth extraction to limit this phenomenon. The benefits of a flapless procedure include maintenance of the buccal ...
Bui Huyen T - - 2012
To initiate mitochondrial fission, dynamin-related proteins (DRPs) must bind specific adaptors on the outer mitochondrial membrane. The structural features underlying this interaction are poorly understood. Using yeast as a model, we show that the Insert B domain of the Dnm1 guanosine triphosphatase (a DRP) contains a novel motif required for ...
Tzovara Athina - - 2012
Auditory evoked potentials are informative of intact cortical functions of comatose patients. The integrity of auditory functions evaluated using mismatch negativity paradigms has been associated with their chances of survival. However, because auditory discrimination is assessed at various delays after coma onset, it is still unclear whether this impairment depends ...
Vishnuvardhan Reddy S - - 2012
Two helical shaped bacteria (strain JC133T and JC143) which stain Gram-negative were isolated from an alkaline soda lake, Lonar, India. Both strains are obligate anaerobes, mesophilic and require halo-alkaline conditions for growth. Both strains are resistant to rifampicin and kanamycin, but sensitive to gentamycin, tetracycline, ampicillin and chloramphenicol. Both strains ...
Wang Jiaxu - - 2012
Abstract A new species of monorchiid trematode, Leiomonorchis zhanjiangensis n. sp. (Trematoda: Monorchiidae), is described from the intestine of marine fish Secutor ruconius (Hamilton-Buchanan) (Leiognathidae) from Zhanjiang (21°2´N, 110°3´E), Guangdong Province, China. The new species is distinguished from all known species of the genus, mainly by the configuration of vitelline ...
Tsoi Georgiy M - - 2012
High-pressure electrical resistance measurements have been performed on single crystal Ba(0.5)Sr(0.5)Fe(2)As(2) platelets to pressures of 16 GPa and temperatures down to 10 K using designer diamond anvils under quasi-hydrostatic conditions with an insulating steatite pressure medium. The resistance measurements show evidence of pressure-induced superconductivity with an onset transition temperature at ∼31 K and ...
Ye Chu-Yu - - 2012
There are a large number of "non-family" (NF) genes that do not cluster into families with three or more members per genome. While gene families have been extensively studied, a systematic analysis of NF genes has not been reported. We performed comparative studies on NF genes in 14 plant species. ...
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