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Results 301 - 350 of 2432
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Ziauddeen H - - 2012
The opioid system is implicated in the hedonic and motivational processing of food, and in binge eating, a behaviour strongly linked to obesity. The aim of this study was to evaluate the effects of 4 weeks of treatment with the mu-opioid receptor antagonist GSK1521498 on eating behaviour in binge-eating obese ...
Leusen Jeanette H W JH Immunotherapy Laboratory, University Medical Center, Utrecht, the Netherlands. - - 2012
The 'Immunoreceptors' meeting took place in July 2012 in beautiful Snowmass Village in Colorado, USA. At an altitude of more than two kilometres, researchers and clinicians discussed the molecular aspects of immunoreceptors, ranging from B- and T-cell receptors, to complement and Fc receptors.
Varela Luis L Program in Integrative Cell Signalling & Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, - - 2012
With the steady rise in the prevalence of obesity and its associated diseases, research aimed at understanding the mechanisms that regulate and control whole body energy homeostasis has gained new interest. Leptin and insulin, two anorectic hormones, have key roles in the regulation of body weight and energy homeostasis, as ...
Zuela Noam N Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, - - 2012
Lamins are nuclear intermediate filament proteins. They provide mechanical stability, organize chromatin and regulate transcription, replication, nuclear assembly and nuclear positioning. Recent studies provide new insights into the role of lamins in development, differentiation and tissue response to mechanical, reactive oxygen species and thermal stresses. These studies also propose the ...
Park Chungoo C Department of Ecology and Evolutionary Biology, University of Michigan, 1075 Natural Science Building, 830 North University Avenue, Ann Arbor, Michigan 48109, - - 2012
Reporter gene assays have demonstrated both transcription-associated mutagenesis (TAM) and transcription-coupled repair, but the net impact of transcription on mutation rate remains unclear, especially at the genomic scale. Using comparative genomics of related species as well as mutation accumulation lines, we show in yeast that the rate of point mutation ...
He Jun J State Key Lab of Reproductive Medicine, Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing 210029, PR - - 2012
Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR-199a and miR-125b target ERBB2 and/or ERBB3 in ovarian cancer cells, and ...
Sibarita Jean-Baptiste JB University of Bordeaux, Interdisciplinary Institute for Neuroscience, CNRS, Bordeaux, France. - - 2012
The second 'Single Molecule Localization Microscopy' symposium was held in August 2012 at the École Polytechnique Fédérale de Lausanne in Switzerland. During two and a half days, around 100 researchers from across the globe, and in disciplines spanning physics, biology, chemistry and computer science, gathered to discuss the developments in ...
Qi Peng P National Key Laboratory of Plant Molecular Genetics and National Center for Plant Gene Research (Shanghai), Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, - - 2012
Increased crop yields are required to support rapid population growth worldwide. Grain weight is a key component of rice yield, but the underlying molecular mechanisms that control it remain elusive. Here, we report the cloning and characterization of a new quantitative trait locus (QTL) for the control of rice grain ...
Green Jennifer Greif JG School of Education, Boston University, Boston, MA, - - 2012
We examine differential validity of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) diagnoses assessed by the fully-structured Composite International Diagnostic Interview Version 3.0 (CIDI) among Latino, non-Latino Black, and non-Latino White adolescents in comparison to gold standard diagnoses derived from the Schedule for Affective Disorders and ...
Mössinger Julia J Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 6, 14195 Berlin, - - 2012
Phosphatidylinositol (PI) 4-phosphate (PI(4)P) and its metabolizing enzymes serve important functions in cell signalling and membrane traffic. PI 4-kinase type IIα (PI4KIIα) regulates Wnt signalling, endosomal sorting of signalling receptors, and promotes adaptor protein recruitment to endosomes and the trans-Golgi network. Here we identify the E3 ubiquitin ligase Itch as ...
Jiang Jing J Group of Epigenetic Reprogramming, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, - - 2013
Induced pluripotent stem (iPS) cells generated using Yamanaka factors have great potential for use in autologous cell therapy. However, genomic abnormalities exist in human iPS cells, and most mouse iPS cells are not fully pluripotent, as evaluated by the tetraploid complementation assay (TCA); this is most likely associated with the ...
Nyholm Spencer V SV Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269, USA. - - 2012
The innate immune system is present in all animals and is a crucial first line of defence against pathogens. However, animals also harbour large numbers of beneficial microorganisms that can be housed in the digestive tract, in specialized organs or on tissue surfaces. Although invertebrates lack conventional antibody-based immunity, they ...
Liu Xingping X Department of Biomedical Engineering, University of California, Irvine, California 92697, - - 2013
Continuum solvent treatments based on the Poisson-Boltzmann equation have been widely accepted for energetic analysis of biomolecular systems. In these approaches, the molecular solute is treated as a low dielectric region and the solvent is treated as a high dielectric continuum. The existence of a sharp dielectric jump at the ...
Ansong Charles C Biological Sciences Division, Pacific Northwest National Laboratory, P. O. Box 999, Richland, WA 99352, - - 2013
The underlying mechanisms that lead to dramatic differences between closely related pathogens are not always readily apparent. For example, the genomes of Yersinia pestis (YP) the causative agent of plague with a high mortality rate and Yersinia pseudotuberculosis (YPT) an enteric pathogen with a modest mortality rate are highly similar ...
Castiello Luciano L Cell Processing Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, - - 2013
Cell-based immunotherapies are among the most promising approaches for developing effective and targeted immune response. However, their clinical usefulness and the evaluation of their efficacy rely heavily on complex quality control assessment. Therefore, rapid systematic methods are urgently needed for the in-depth characterization of relevant factors affecting newly developed cell ...
Chiorazzi Nicholas N Karches Center for Chronic Lymphocytic Leukemia Research, The Feinstein Institute for Medical Research, Hofstra North Shore-LIJ School of Medicine, 350 Community Drive, Manhasset, NY 10030, USA. - - 2013
The significant correlation between disease aggressiveness and the gene and protein structures of the B-cell receptors (BCRs) expressed on chronic lymphocytic leukemia (CLL) cells, together with the evidence for chronic activation of the BCR pathway, have led to the hypothesis that this leukemia initiates and progresses by selecting normal B ...
Chen Shuyi S Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. - - 2013
The optic fissure (OF) is a transient opening on the ventral side of the developing vertebrate eye that closes before nearly all retinal progenitor cell differentiation has occurred. Failure to close the OF results in coloboma, a congenital disease that is a major cause of childhood blindness. Although human genetic ...
Burr Stephen P SP Regulatory T Cell Laboratory, Department of Veterinary Clinical Sciences, Royal Veterinary College, London, - - 2013
In recent years, mesenchymal stromal cells (MSCs) and regulatory T cells (Tregs) have both garnered significant interest from immunologists worldwide, not least because of the potential application of both cell types in the treatment of many chronic inflammatory and autoimmune diseases. Although both MSCs and Tregs can be considered immunosuppressive ...
Venkatesh Swaminathan S Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, - - 2013
An abundance of long non-coding RNA (lncRNA) present in most species from yeast to human are involved in transcriptional regulation, dosage compensation and imprinting. This underscores the importance of lncRNA as functional RNA despite the fact that they do not produce proteins. Two recent papers in Cell have demonstrated that ...
Chen Huan H Department of Microbiology & Immunology, Columbia University Medical Center, New York, NY 10032, - - 2013
Repair of double-strand breaks by homologous recombination requires Repair of double-strand breaks by homologous recombination requires 5'-3' resection of the DNA ends to create 3' single-stranded DNA tails. While much progress has been made in identifying the proteins that directly participate in end resection, how this process occurs in the ...
Bottini Nunzio N Division of Cellular Biology, La Jolla Institute of Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, - - 2013
Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key component of this invasive synovium and have a major role in the initiation and perpetuation of destructive joint inflammation. The pathogenic potential of FLS in RA stems ...
de Raaf P J PJ Department of Medical Oncology, Daniel den Hoed Cancer Center, Erasmus MC, Rotterdam, The Netherlands. - - 2013
Although the multidimensional nature of cancer-related fatigue is widely accepted, it could be questioned whether fatigue dimensions are expressions of one symptom (multidimensional concept) or expressions of several phenomena that are all called fatigue but actually are separate symptoms (multiple-symptom concept). Therefore, we investigated in this review whether physical fatigue ...
Nanda Kavinderjit S KS Center for Inflammatory Bowel Disease, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, - - 2013
Antibodies to infliximab (ATIs) have been associated with loss of clinical response and lower serum infliximab (IFX) levels in some studies of patients with inflammatory bowel disease (IBD). This has important implications for patient management and development of novel biologic therapies. The objective of this study was to perform a ...
Nordenstedt Helena H Houston VA HSR&D Center of Excellence, Houston, TX, - - 2013
Recent studies using histology alone in select patients have suggested that Helicobacter pylori-negative gastritis may be common. The objective of this study was to investigate the prevalence of H. pylori among individuals with histologic gastritis. Subjects between 40 and 80 years underwent elective esophagogastroduodenoscopy at a VA Medical Center. Gastric ...
Gellhorn Alfred C AC Department of Rehabilitation Medicine, University of Washington Medical Center, Box 354740, 4245 Roosevelt Way NE, Seattle, WA 98105, - - 2013
Osteoarthritis (OA) of the spine involves the facet joints, which are located in the posterior aspect of the vertebral column and, in humans, are the only true synovial joints between adjacent spinal levels. Facet joint osteoarthritis (FJ OA) is widely prevalent in older adults, and is thought to be a ...
Chen C - - 2012
Schizophrenia (SCZ) and bipolar disorder (BD) are highly heritable psychiatric disorders. Associated genetic and gene expression changes have been identified, but many have not been replicated and have unknown functions. We identified groups of genes whose expressions varied together, that is co-expression modules, then tested them for association with SCZ. ...
Turner Nicholas C - - 2012
ABSTRACT: A recent prospective clinical trial provides further evidence that breast cancers arising in germline BRCA1 mutation carriers are highly sensitive to cisplatin chemotherapy. The potential significance of these data for the management of patients with BRCA1-related and BRCA2-related breast cancer is discussed.
Camilleri Michael M Department of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA. - - 2013
This guideline presents recommendations for the evaluation and management of patients with gastroparesis. Gastroparesis is identified in clinical practice through the recognition of the clinical symptoms and documentation of delayed gastric emptying. Symptoms from gastroparesis include nausea, vomiting, early satiety, postprandial fullness, bloating, and upper abdominal pain. Management of gastroparesis ...
Rametta R R Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, - - 2013
The aim of this study was to evaluate whether dysregulation of molecules involved in FOXO1-dependent insulin signaling in the liver is associated with de novo lipogenesis (DNL) and altered lipid metabolism in severely obese subjects. Observational retrospective study. We considered 71 obese subjects (age 20-68 years; body mass index (BMI)>40 kg m(-2) ...
Booth Sarah L SL Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. - - 2013
Increasing evidence supports an association between the skeleton and energy metabolism. These interactions are mediated by a variety of hormones, cytokines and nutrients. Here, the evidence for a role of osteocalcin in the regulation of glucose metabolism in humans is reviewed. Osteocalcin is a bone matrix protein that regulates hydroxyapatite ...
Limnell Katriina - - 2012
Background and aims: The purpose of the present cross-sectional study was to analyze how knee replacement affects performance in activities of daily living (ADL), mobility, and pain in older patients with knee osteoarthritis. Methods: Knee osteoarthritis patients aged ≥ 75 years scheduled for knee replacement (Group 0, n=68), or having ...
Brunberg Emma - - 2012
Knowledge about gene expression in animals involved in abnormal behaviours can contribute to understanding of the underlying biological mechanisms. The present study aimed to explore the motivational background to tail biting, an abnormal injurious behavior and severe welfare problem in pig production. Affymetrix microarrays were used to investigate gene expression ...
Harris E K - - 2012
Yorkshire gilts either remained in their individual stall from d 40 to term (CON; n = 7), or were subjected to exercise for 30 min 3 times per week from mid to late gestation (EX; n = 7) to determine the impact of increased maternal activity during gestation on maternal ...
Morra Marco - - 2012
Abstract Osteoimmunology, i.e. the cross-talk between cells from the immuno and skeletal systems, suggests a role of pro-inflammatory cytokines in the stimulation of osteoclasts activity. Endotoxin or bacterial challenges to inflammatory cells are directly relevant to dental implants pathologies involving bone resorption, such as osteointegration failure and periimplantitis. While the ...
Garcia-Portilla M P - - 2012
AIMS: To update and summarise the scientific knowledge on the long-term outcomes of the different pharmacological treatment options for opioid dependence currently available and to provide a critical discussion on the different treatment options based on these results. METHODS: We performed a literature search using the PubMed databases and the ...
Port John D - - 2012
PURPOSE: (i) To develop an MRS technique to measure (7) Li levels in human brain in a reasonable scan time, (ii) to develop a technique to quantify (7) Li T2 relaxation times as measured from human brain in patients taking lithium for the treatment of their bipolar disorder, and (iii) ...
Zilberberg Liat - - 2012
The growth mechanism of TiO2 films and their morphology are reported using Reactive Layer Assisted Deposition (RLAD) method under ultra high vacuum conditions. The oxide film formation involves Ti atoms deposition on top of amorphous solid water (ASW) condensed on a SiO2/Si(100) support at 90K. Subsequent annealing leads to desorption ...
Ujiie Hideyuki - - 2012
Congenital molluscum contagiosum is rare but has been reported previously. We present a unique case of linear congenital molluscum on the coccygeal region. To make a correct diagnosis, avoid unnecessary examination, and start appropriate treatment as soon as possible, it is beneficial for dermatologists to be aware that molluscum contagiosum ...
Gajic-Veljic Mirjana - - 2012
Granulomatosis with polyangiitis (GPA), also known as Wegener's granulomatosis, is a rare disease in childhood. Of 39 GPA patients that we diagnosed during a 20-year period, only 3 (7.7%) were younger than 18 years. We report the course of GPA in three girls whose disease started at the ages of ...
Fukaya Shinji - - 2012
TNF-α-converting enzyme (TACE) can cleave transmembrane proteins, such as TNF-α, TNF receptors, and epidermal growth factor receptor (EGFR) ligands, to release the extracellular domains from the cell surface. Recent studies have suggested that overexpression of TACE may be associated with the pathogenesis of inflammation and fibrosis. To determine the roles ...
Makeyev Aleksandr V - - 2012
Objectives :  GTF2I and GTF2IRD1 genes located in Williams-Beuren syndrome (WBS) critical region encode TFII-I family transcription factors. The aim of this study was to map genomic sites bound by these proteins across promoter regions of developmental regulators associated with craniofacial development. Design :  Chromatin was isolated from human neural ...
Muraoka Takahiro - - 2012
A multiblock amphiphilic molecule 1, with a tetrameric alternating sequence of hydrophilic and hydrophobic units, adopts a folded structure in a liposomal membrane like a multipass transmembrane proteins, and is able to transport alkali metal cations through the membrane. Hill's analysis and conductance measurements, analyzed by the Hille equation, revealed ...
Bressani V O - - 2012
Dermatophytes invade the stratum corneum of the skin and other keratinized tissues such as hair and nails, and Trichophyton rubrum causes approximately 80% of cutaneous mycoses in humans. To evaluate the cellular immune response of patients with extensive dermatophytosis caused by T. rubrum, we evaluated lymphocyte populations, the lymphoproliferative response ...
Schmidt Anja - - 2012
In flowering plants, double fertilization of the female gametes, the egg and central cell, initiates seed development to give rise to a diploid embryo and the triploid endosperm. In the absence of fertilization, the MEA-FIE Polycomb Repressive Complex 2 (PRC2) represses this developmental process by histone methylation of certain target ...
Schenzel Judith - - 2012
Mycotoxins are secondary metabolites that are naturally produced by fungi which infest and contaminate agricultural crops and commodities (e.g., small grain cereals, fruits, vegetables, and organic soil material). Although these compounds have extensively been studied in food and feed, only little is known about their environmental fate. Therefore, we investigated ...
Kazak Alexandr Vasilevich - - 2012
In order to study the influence of structure peculiarities of porphyrin derivatives on their supramolecular organization in thin films, 15 new meso-substituted tetraphenylporphyrin derivatives and their metal complexes with substituents (-OC4H9 or -OC16H33) in para- or ortho-positions were studied. The films of the studied compounds were obtained by Langmuir-Schaefer method. ...
Lancuski Anica - - 2012
This paper reports highly surface functionalized and 'clickable' α,ω-azido-poly(ε-caprolactone) fibers (f-PCL-N3), obtained by classical electrospinning setup. Azide-functionalized PCL was obtained from a commercially available α,ω-poly(ε-caprolactone)-diol, PCL2, and electrospun with a non-derivative high molecular weight PCL. Successful chemical modifications of PCL2 were confirmed by NMR, FTIR and MALDI-TOF mass spectroscopy. High ...
Di Cagno Alessandra - - 2012
In the angiotensin-converting enzyme (ACE) gene, Alu deletion, in intron 16, is associated with higher concentrations of ACE serum activity and this may be associated with elite sprint and power performance. The Alu insertion is associated with lower ACE levels and this could lead to endurance performance. Moreover, recent studies ...
Rullaud Vanessa - - 2012
An amphiphilic calix[4]arene derivative bearing four guanidino moieties at the upper rim and four dodecyl chains at the lower rim was shown to form stable solid lipid nanoparticles (SLNs) in water. The study of the interactions of these cationic SLNs with DNA revealed a sequence-dependent groove binding mechanism.
McDaniel Kristin A - - 2012
  Peanuts in North America and Europe are primarily consumed after dry roasting. Standard industry practice is to roast peanuts to a specific surface color (Hunter L-value) for a given application; however, equivalent surface colors can be attained using different roast temperature/time combinations, which could affect product quality. To investigate ...
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