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Results 251 - 300 of 2432
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Arcadi Antonio - - 2012
The scope and the generality of gold versus silver catalyzed intramolecular hydroarylation reactions of 3-[(3-arylprop-2-ynyl)oxy]benzene derivatives in terms of rings substitution were investigated. Only products deriving from 6-endo cyclization were exclusively formed. The features of substituents had a considerable effect on the reaction outcome in the presence of silver catalysis, ...
- - 2012
The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the most read manuscripts published on the topic of ...
Win-Shwe Tin-Tin - - 2012
Previously, we demonstrated that maternal exposure to phthalates enhances atopic dermatitis in male mouse offspring. However, whether phthalate exposure affects neuroimmune biomarkers in allergic mice has not yet been studied. Di-(2-ethylhexyl) phthalate (DEHP) and di-isononyl phthalate (DINP) are environmental chemicals that are commonly used as plasticizers. This study was designed ...
Li Yibao - - 2012
We investigate the influence of temperature on the self-assembly of 2,6,11-tricarboxydecyloxy-3,7,10-triundecyloxy triphenylene (asym-TTT) adsorbed on HOPG using scanning tunneling microscopy (STM) at the liquid/solid interface. We show that the packing structures of 2D self-assembled asym-TTT can be precisely tuned by adjusting the substrate temperature. The temperature change from 20 °C ...
Nabika Hideki - - 2012
The ability to control chemical wave propagation dynamics could stimulate the science and technology of artificial and biological spatiotemporal oscillating phenomena. In contrast to the conventional chemical approaches to control the wave front dynamics, here we report a physical approach to tune the propagation dynamics under the same chemical conditions. ...
Akkoç Y - - 2012
Study design:Multi-center, cross-sectional study.Objectives:To investigate the effects of different bladder management methods on the quality of life (QoL) in patients with spinal cord injury (SCI).Setting:Turkey.Methods:Consecutive SCI patients (n=195, 74.4% males), for whom at least 6 months had elapsed since the injury, were included and evaluated in five groups: normal spontaneous ...
Folkesson Anders - - 2012
The airways of patients with cystic fibrosis (CF) are nearly always infected with many different microorganisms. This environment offers warm, humid and nutrient-rich conditions, but is also stressful owing to frequent antibiotic therapy and the host immune response. Pseudomonas aeruginosa is commonly isolated from the airways of patients with CF, ...
Valette M - - 2012
Melanocortin-4 receptor (MC4R) mutations are the most common known cause of monogenic obesity and an important contributor to polygenic obesity. MC4R mutations with partial or total loss of function, as well as the variant rs17782313 mapped near MC4R, are positively associated with obesity. MC4R is involved in the leptin-melanocortin signalling ...
Lebeau Richard T - - 2012
In preparation for DSM-5's planned inclusion of dimensional assessments of psychopathology as a complement to traditional categorical diagnoses, we developed brief self-rated scales for anxiety disorders that are consistent in content and structure. In the present paper, we discuss the creation of the scales and examine their psychometric properties and ...
Pongratz Georg - - 2012
The peripheral nervous system takes an active part in inflammatory processes by regulating effector cell function and reallocation of energy to the immune system. During acute inflammation, rapid neuronal reorganization and change of activity takes place. The hallmarks of this process are an increase in systemic sympathetic activity, a decrease ...
Lambert Carole - - 2012
The interaction between Vitis vinifera and trunk disease fungi requires better understanding. We studied the role of phenolics as possible plant defense compounds in this context. The impact of 24 grapevine phenolic compounds was determined on 6 major wood decay fungi by an in vitro agar plate assay. Hydroxystilbenoids, especially ...
Alrehaily L M - - 2012
The formation of chromium oxide nanoparticles by gamma radiolysis of Cr(VI) (CrO(4)(2-) or Cr(2)O(7)(2-)) solutions was investigated as a function of pH and initial Cr(VI) concentration by measuring [Cr(VI)], the particle concentration ([Cr(III)(col)]) and [H(2)], and by characterizing the particles using TEM, Raman, FTIR and XPS. The results show that ...
Lamb Christopher A - - 2012
Two key questions in the autophagy field are the mechanisms that underlie the signals for autophagy initiation and the source of membrane for expansion of the nascent membrane, the phagophore. In this review, we discuss recent findings highlighting the role of the classical endosomal pathway, from plasma membrane to lysosome, ...
Chun So Young - - 2012
This study investigated the differentiation of human amniotic fluid-derived stem cells (hAFSCs) into insulin-producing clusters in vitro. Adenovirally-delivered mouse Pdx1 (Ad-Pdx1) induced human Pdx1 expression in hAFSCs and enhanced the coordinated expression of downstream β-cell markers. When Ad-Pdx1-transduced hAFSCs were sequentially treated with activin A, bFGF and nicotinamide and the ...
Sprangers Ben - - 2012
Relapses or flares of systemic lupus erythematosus (SLE) are frequent and observed in 27-66% of patients. SLE flares are defined as an increase in disease activity, in general, requiring alternative treatment or intensification of therapy. A renal flare is indicated by an increase in proteinuria and/or serum creatinine concentration, abnormal ...
Dani Carlo - - 2012
Abstract Objectives: Our aim was to assess whether non-invasive ventilation with heliox may decrease the incidence of extubation failure in preterm infants with RDS. Methods: Infants <29 weeks of gestation were treated immediately after extubation with heliox combined with nasal continuous airway pressure (Hx-NCPAP) or bilevel NCPAP (Hx-BiPAP) for 24 ...
Villanueva Augusto - - 2012
The management of hepatocellular carcinoma (HCC) has substantially changed in the past few decades. Improvements in patient stratification (for example, using the Barcelona Clinic Liver Cancer staging system) and the introduction of novel therapies (such as sorafenib) have improved patient survival. Nevertheless, HCC remains the third most common cause of ...
Kadappu Subhashini - - 2012
BACKGROUND: This paper reports on the aetiology and outcome of childhood open and closed globe eye injuries presenting to the Children's Hospital at Westmead, Sydney, Australia from January 2000 to December 2008. DESIGN: Hospital-based retrospective study PARTICIPANTS: Two hundred and three cases of childhood eye injuries identified in a 9 ...
McKay Dianne - - 2012
The world population is rapidly growing and ageing at a pace that is projected to continue for at least three decades. This shift towards an older populace has invariably increased the number of individuals with diseases related to ageing, such as chronic kidney disease. The increase in chronic kidney disease ...
Salter Susannah J - - 2012
This month's Genome Watch highlights new insights into the use of bacteria in industrial processes such as electricity generation and bioremediation.
Morita Masato - - 2012
We present theoretical calculations on the vibrational spectra between the energy range of 2000-4000 cm(-1) for 4 isoenergetic conformers of gas phase OH(-)(H(2)O)(3) and OH(-)(H(2)O)(3)·Ar clusters. The peak positions and associated intensities of the OH stretching vibrations were calculated using an extended local mode model on multi-dimensional ab initio potential ...
Coron F - - 2012
OBJECTIVES: Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder with manifestations mainly involving the skeletal, ocular, and cardiovascular systems. The phenotypic variability observed in MFS makes genetic counselling difficult. Prenatal diagnosis (PND) and preimplantation genetic diagnosis are technically feasible when a causal mutation is identified, but both raise ...
Martis Vladimir - - 2012
In this paper, we report a detailed characterisation of chromium doped iron oxide catalysts using a range of techniques to establish the nature of chromium species in the near surface and bulk of iron oxide, high-temperature shift (HTS) catalysts. In particular we have employed X-ray absorption spectroscopy Cr K-edge near ...
Hoppe Berthold - - 2012
Activation of the immune system has been increasingly recognised to be associated with procoagulatory status in patients with inflammatory rheumatic disease. Changes in endothelial cell and platelet activation, blood flow, expression and activity of different coagulation factors, and impaired fibrinolysis serve as pathophysiological basis for enhanced risk of venous thromboembolism ...
Cotignola J - - 2012
Background:Organ confined prostate cancer (PCa) can be cured by radical retropubic prostatectomy (RRP); however, some tumors will still recur. Current tools fail to identify patients at risk of recurrence. Glutathione-S-transferases (GSTs) are involved in the metabolism of carcinogens, hormones and drugs. Thus, genetic polymorphisms that modify the GST activities may ...
Viswanathan Deepa - - 2012
BACKGROUND: Collagen crosslinking has been reported to be effective in treating progressive keratoconus and this study aims to evaluate the long term efficacy of this procedure. DESIGN: Prospective longitudinal interventional study of patients with progressive keratoconus who underwent crosslinking in a tertiary referral hospital. PARTICIPANTS: Thirty five patients (fifty one ...
Rolland-Cachera M F - - 2012
Background:There is overwhelming evidence that experiences during early life could have long-term health consequences. However, the role of early nutrition in programming obesity and leptin resistance is still poorly understood.Objective:We aimed at determining whether nutritional intakes in early life are associated with body composition and hormonal status at 20 years.Subjects:Healthy ...
Hiatt Kelly - - 2012
Muscle progenitor cells (MPCs) are currently being investigated as cellular vectors to deliver neurotrophic factor (NF) for the promotion of re-innervation after axonal injury. Ideally NF delivery in such a model would enhance axonal regeneration while simultaneously promoting MPC viability. To date, insulin-like growth factor 1 (IGF-1) is one of ...
Gez Liron Suzanne - - 2012
The activation of the ryanodine Ca2+-release channels (RyR2) by Ca2+ entry through the L-type Ca2+-channels (Cav1.2) is believed to be the primary mechanism of Excitation-Contraction (EC) coupling in cardiac cells. This proposed mechanism of Ca2+-induced-Ca2+-release (CICR), cannot fully account for the lack of a termination signal for this positive feedback ...
Xu Weixin - - 2012
The structural characterization of amyloid fibers is one of the most investigated areas in structural biology. Recently, protofibril models for amylin, i.e., the 37-residue human islet amyloid polypeptide or hIAPP were suggested by two groups based on NMR (Luca et al., Biochemistry 2007;46:13505-13522) and X-ray (Wiltzius et al., Protein Sci ...
Matsui Shoko - - 2012
SUMMARY AT A GLANCE: The clinicoradiological and pathological features of IgG4-related lung disease were assessed. Clinically, this disease is silent, although radiological and pathological examinations showed that it involves lymphatic routes, with spread observed on imaging and infiltration on pathological examination. Clinicoradiological and pathological correlation is necessary for the diagnosis ...
Strömberg Ella - - 2012
Abstract Objectives. To describe the oral health-related quality-of-life in homebound elderly dependent on moderate and substantial supportive care for daily living. Materials and methods. A total of 302 selected persons in three counties in Sweden over 65 years of age and in need of daily support from society participated in ...
Cantillo-Baños Enrique - - 2012
Abstract Conclusion: The choice of technique will depend on the glottic gap observed by stroboscopy, the alteration of the Voice Handicap Index (VHI) and the recorded values of harmonics-to-noise ratio (HNR), jitter and shimmer, and the general health, age and underlying pathology. There are statistically significant differences between the values ...
Cassidy Andrew - - 2012
Data are presented showing the spontaneous formation of electric fields within solid films of the chlorofluorocarbons (CFCs) CF(3)Cl, CF(2)Cl(2) and CFCl(3) as a function of film deposition temperature from 40 K and above. Electric fields, which arise through dipole alignment and lie in the range of a few times 10(7) ...
Aquino Priscila F - - 2012
A strategy for treating cancer is to surgically remove the tumor together with a portion of apparently healthy tissue surrounding it, the so-called "resection margin", to minimize recurrence. Here, we investigate whether the proteomic profiles from biopsies of gastric cancer resection margins are indeed more similar to those from healthy ...
Lee Roland Y - - 2012
BACKGROUND: To determine the association between ethnicity and changes in intraocular pressure (IOP) and anterior segment biometric parameters following cataract surgery by phacoemulsification in nonglaucomatous subjects. DESIGN: Prospective clinical cohort study. PARTICIPANTS: Caucasian and Asian subjects. METHODS: Anterior segment optical coherence tomography (ASOCT) scans under dark conditions and IOP measurements ...
Luqmani Raashid - - 2012
A fundamental change in management of antineutrophil cytoplasmic antibody-associated vasculitis in the past 10 years is the early focussed use of aggressive immunosuppression, using regimens comprised of widely available medications. Using a clinical framework to quantify morbidity, we can induce remission in most patients within 3-6 months using glucocorticoids plus ...
Piao Yunxian - - 2012
Molecular beacons (MBs) have shown fascinating applications in many biological fields. However, exploration of cost-effective, sensitive, stable and efficient MB for in situ live cell- based assay has still room for improvement. In this regards, we have developed a novel MB which bears a spherical graphite nanoparticle (GN) as a ...
Arfin T - - 2012
A new crystalline organic-inorganic nano-composite nylon-6,6 nickel phosphate membrane was synthesised subsequent to which (a) the physico-chemical characteristics of the membrane were evaluated employing FTIR, SEM, EDX, TEM, XRD and porosity measurements, and (b) membrane potential measurements were conducted employing different concentrations (0.0001 ≤ c (M) ≤ 1) of KCl, ...
Hsieh Ya-Lin - - 2012
This study investigated the relationship between mothers' daily occupational experiences of productivity, restoration and pleasure with their subjective well-being (SWB) and with their child's developmental skills. Forty caregivers parenting young children with autism spectrum disorders served as a convenience sample in this study. Participants rated their occupational experience in a ...
Söderberg M M - - 2012
The widely used antipsychotic drug, olanzapine (OLA) shows large interindividual variability in metabolic clearance. Although the role of the enzymes CYP1A2, CYP2D6 and UGT1A4 has been extensively explored, little is known about the in vivo role of flavin-containing monooxygenases (FMOs) catalyzing the N-oxidation of OLA in vitro. We investigated the ...
Hassel Alexander J - - 2012
Abstract Objectives. Because of its good matching performance the VITA 3D-Master shade guide (3D) is frequently used for determination of tooth color. Numerous composites/ceramics are, however, available in VITA Classical (VC) shades only. The objective of this study was to investigate the possibility of performing a shade match with 3D ...
Srinivasan Sathish - - 2012
The presence of pre-existing corneal opacities during cataract surgery can cause scattering of light from the operating microscope, limiting the surgeon's view of the anterior chamber (AC). In this context, combined corneal transplantation and cataract surgery may be preferential. However, patients with mild to moderate nebulae may prefer to undergo ...
Sadr-Azodi O - - 2012
OBJECTIVES:Previous research has indicated that obesity may be linked to the severity of acute pancreatitis. However, the association between abdominal and total adiposity as risk factors in the development of acute pancreatitis in a general population has not been studied.METHODS:A follow-up study was conducted, using the Swedish Mammography Cohort and ...
Knapp Caroline M - - 2012
Reaction of an ethylenediamine solution of K(3)As(7) with the low-valent, low-coordinate cobalt(ii) complex [Co(mes)(2)(PEt(2)Ph)(2)] yielded the novel dianionic species [Co(η(3)-As(3)){η(4)-As(4)(mes)(2)}](2-) (1). The [η(4)-As(4)(mes)(2)](2-) moiety present in 1 is a rare example of a group 15 analogue of a butadienediide.
Teng Jingfei - - 2013
To assess the overall efficacy and safety of photoselective vaporization of the prostate (PVP) vs transurethral resection of the prostate (TURP) for treating patients with lower urinary tract symptoms (LUTS) secondary to benign prostate hyperplasia (BPH). A systematic search of the electronic databases, including MEDLINE, Embase, Web of Science and ...
Moeller L - - 2012
Abstract Objective. The aim of this study was to compare the presence of voids in root fillings performed in oval and ribbon-shaped canals with two root filling techniques, lateral compaction technique (LCT) or hybrid technique (HT), a combination of a gutta-percha masterpoint and thermoplastic gutta-percha. Furthermore, the obturation time for ...
Bannert Christina - - 2012
Quality indicators including cecal intubation rate (CIR) and adenoma detection rate (ADR) are established. Sex differences of quality indicators are observed, but the influence of sedation has not been investigated so far. The objective of this study is to assess the impact of sedation on quality indicators, including CIR and ...
Flores G - - 2013
Severe obesity has increased >300% in US children since 1976, and is associated with multiple cardiovascular risk factors and high adult obesity rates. The objective of this study was to identify predictors of severe obesity in kindergarteners. Multivariable logistic regression and recursive partitioning analysis (RPA) were used to identify prenatal/pregnancy, ...
Ziauddeen H - - 2012
The opioid system is implicated in the hedonic and motivational processing of food, and in binge eating, a behaviour strongly linked to obesity. The aim of this study was to evaluate the effects of 4 weeks of treatment with the mu-opioid receptor antagonist GSK1521498 on eating behaviour in binge-eating obese ...
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