Search Results
Results 201 - 250 of 2432
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Li Xiaoqing - - 2012
Sulfonyl radicals generated from sulfonylhydrazides by the Bu(4)NI-tert-butyl hydroperoxide (TBHP) catalysis system underwent addition to a variety of α-methyl styrene derivatives to give the corresponding allylic sulfones. This selective allylic sulfonylation is metal-free, operationally simple, and environmentally friendly.
Bessissow Talat - - 2012
OBJECTIVES:Endoscopic mucosal healing is a key endpoint for the treatment of ulcerative colitis (UC). The role of microscopic activity in predicting disease relapse has not been fully assessed. We aimed to investigate the predictive role of serologic and histologic markers on disease relapse in UC patients with endoscopically inactive disease.METHODS:Adult ...
Pomp Oz - - 2012
The ability to convert human somatic cells into induced pluripotent stem cells (iPSCs) is allowing the production of custom-tailored cells for drug discovery and for the study of disease phenotypes at the cellular and molecular level. IPSCs have been derived from patients suffering from a large variety of disorders with ...
Hagiwara M - - 2012
Background:Patients with bone metastases secondary to prostate cancer are predisposed to skeletal-related events (SREs), including spinal cord compression, pathological fracture, surgery to bone and radiotherapy to bone. The objective of this study was to document current patterns of healthcare utilization and costs of SREs in patients with prostate cancer and ...
Schoepke Nicole - - 2012
This randomized, double-blind, placebo-controlled crossover study compared inhibition by one 5 mg dose of levocetirizine with two 60 mg doses of fexofenadine separated by 12 h of histamine-induced wheal and flare responses in 9 Caucasian and 9 Japanese healthy male volunteers. Levocetirizine was more inhibitory than fexofenadine on wheal, flare ...
Pan Ling - - 2012
Ketene dithioacetals are versatile intermediates in organic synthesis. Extensive research, since the last decade, has given rise to new prospects in their chemistry. The objective of this review is twofold: first, to highlight the new prospects in the chemistry of functionalized ketene dithioacetals, and second, to provide an intrinsic link ...
Waters M - - 2012
Background:The ratio of the second to the fourth digit (2D:4D ratio) is a sexually dimorphic trait established in utero that differs between ethnic groups. It is associated with prenatal androgen exposure, and studies have evaluated the ratio as a marker for certain traits and disease states known to be associated ...
Yang Juanhua - - 2012
The intramolecular electronic couplings in organic mixed-valence systems [D-(ph)n- D].+ (D=2,5-dimethoxy-4-methylphenyl, n=0,1,2) are calculated by dominantly using density functional theory to investigate their dependence of functionals. Since these systems have the property that the charge is from localization to delocalization, the optimized structures are sensitive to the functionals. The geometric ...
Fernandez Oscar - - 2012
Multiple sclerosis is a progressive demyelinating neurological disease resulting in long-term disability, commonly manifesting in walking impairment and reduced quality of life. The use of the potassium channel blocker fampridine, chemically 4-aminopyridine, as an immediate-release formulation to improve action potential conduction in demyelinated axons was hampered by adverse events, including ...
Laajasalo Taina - - 2012
BACKGROUND: Despite a growing forensic psychiatry literature, no previous study has examined in detail homicidal behaviour among offenders with cluster C personality disorders - the avoidant, dependent or obsessional personality disorders. AIMS: This study aims to compare homicide offenders with cluster C personality disorders with those with other personality disorders ...
Reinehr T - - 2012
OBJECTIVE:The aim was to analyze the effectiveness of treatment concerning obesity-associated comorbidities in clinical practice.METHODS:A total of 11 681 overweight children with 6-month follow-up treated at 175 centers specialized in pediatric obesity care in Central Europe were included in this analysis (mean body mass index (BMI) 29.0±5.6 kg m(-)(2), standard deviation score body ...
Wang Honggen - - 2012
Taking advantage of Rh(III)-catalyzed C-H activation reactions, we have developed a mild, short and efficient method for the synthesis of bench-stable 3-isoquinolone MIDA boronates. The reaction is practical and scalable. The product formed has been applied in the Suzuki-Miyaura reaction with high efficiency. This strategy has also been successfully expanded ...
Greiner Jack V - - 2012
PURPOSE: To determine the 1-year post-treatment dry eye status of subjects with meibomian gland dysfunction (MGD) and dry eye symptoms after receiving a single LipiFlow® Thermal Pulsation System (LTPS) treatment. DESIGN: Single-center, prospective, observational, open-label, 1-month registered clinical trial with a 1-year follow-up examination. PARTICIPANTS: Patients with evaporative dry eye ...
Barry W - - 2012
Objectives:Hypertension (HTN) is an important risk factor for cardiovascular disease, a major cause of morbidity and mortality among people with spinal cord injury and disorders (SCI/D). Our study examined prevalence, associated factors, and pharmacological treatment of HTN in Veterans with SCI/D compared with a matched control group.Methods:A retrospective review was ...
Fei Jinbo - - 2012
Responsive nanohelices can be self-assembled via asymmetric coordination bonding between AgNO(3) and melamine. Silver nanochains composed of nanoparticles can be synthesized simply by photo-reduction of the above complex.
Mathew A - - 2012
Study design:Cross-sectional survey.Objective:To compare the relationship between engagement in occupational activities and pressure ulcer (PU) development in persons with spinal cord injury (SCI).Study setting:Tertiary care university teaching hospital, Tamil Nadu, India.Method:One hundred and eight persons with SCI who were previously rehabilitated from our center were included in the study. A ...
Briganti Alberto - - 2012
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Previous studies have retrospectively compared functional and oncological outcomes between robot-assisted radical prostatectomy (RARP) and open retropubic radical prostatectomy (RRP), reporting non-inferior or superior outcomes associated with the use of the robotic approach. The study demonstrates that baseline selection ...
Sugitani Ai - - 2012
Selective anodic stripping voltammetry of trace metal ions in a mixture solution with another interfering metal was developed based on Fick's law concerning the diffusion profile of interfering metals at the electrode surface after electrolysis treatment. A boron-doped diamond film was used as the sensing electrode, while a perforated carbon ...
Shin Jung Eun - - 2012
Abstract Conclusion: Vestibular abnormality was found in 84% of patients with Meniere's disease (MD) and 66% of those with migrainous vertigo (MV), even in the interictal period. Although MV does not have proven pathology like endolymphatic hydrops of MD, MV had high vestibular abnormality, suggesting that comorbid vestibular abnormality can ...
Kainuma Kazuyuki - - 2012
Abstract Conclusion: The results of this study accord with those of past reports about the prevalence of level V metastasis in head and neck squamous cell carcinoma (HNSCC) cases. Because of the low rate of level V metastasis, and from the viewpoint of standard postoperative radiotherapy, selective neck dissection without ...
Akoglu Hadim - - 2012
Background: Calcineurin inhibitors, mainly cyclosporin A (CsA), are associated with endothelial dysfunction in renal transplant recipients (RTRs). Hemorheological disturbances including decreased erythrocyte deformability (ED), increased plasma viscosity and erythrocyte aggregation (EA) have also been reported in CsA-treated RTRs. The aim of this study was to investigate the relationship between hemorheological ...
Jackson Andrew - - 2012
Regaining motor function is of high priority to patients with spinal cord injury (SCI). A variety of electronic devices that interface with the brain or spinal cord, which have applications in neural prosthetics and neurorehabilitation, are in development. Owing to our advancing understanding of activity-dependent synaptic plasticity, new technologies to ...
Seyed-Razavi Yashar - - 2012
Membrane nanotubes (MNTs) are newly discovered cellular extensions that are either blind-ended or can connect widely separated cells. They have predominantly been investigated in cultured isolated cells, however, previously we were the first group to demonstrate the existence of these structures in vivo in intact mammalian tissues. We previously demonstrated ...
Sternberg Itay A - - 2012
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Bladder cancer patients with lamina propria invasion (T1 disease) and residual T1 disease on restaging transurethral resection of bladder tumour (re-TURBT) are at a very high risk for recurrence and progression. Despite this risk, most patients are treated with ...
Rawlins B G - - 2012
Regulatory authorities need ways to estimate natural terrestrial gamma radiation dose rates (nGy h(-1)) across the landscape accurately, to assess its potential deleterious health effects. The primary method for estimating outdoor dose rate is to use an in situ detector supported 1 m above the ground, but such measurements are ...
Berzigotti Annalisa - - 2012
OBJECTIVES:Cardiovascular risk factors (CVRF) lead to systemic endothelial dysfunction. It has been suggested that in cirrhosis, cardiovascular risk is low and systemic endothelial function is enhanced. However, there is no prospective study evaluating the relationship between cardiovascular risk and systemic endothelial function in cirrhosis, which was investigated here.METHODS:In 47 patients ...
Michel Jesse S - - 2012
This study examines the relative importance of individual differences in relation to perceptions of work-family conflict and facilitation, as well as the moderating role of boundary preference for segmentation on these relationships. Relative importance analyses, based on a diverse sample of 380 employees from the USA, revealed that individual differences ...
Hernández-Ainsa Silvia - - 2012
We report a simple and efficient way to accomplish the chemical modification of glass nanopores by means of lipid self-assembly. Lipid coating improves the success rate of these glass nanopores as biosensors to detect λ-DNA.
Geyh S - - 2012
Study design:An international cross-sectional study.Objective:To examine the quality of life (QoL) of people with spinal cord injury (SCI) across six countries worldwide, controlling for socio-demographic and lesion-related sample characteristics and using a cross-culturally valid assessment.Methods:Data from 243 persons with SCI from Australia, Brazil, Canada, Israel, South Africa and the United ...
Choi Ik Joon - - 2012
Abstract Conclusion: ERCC 1 seems to be promising as a predictive marker for response to neoadjuvant chemotherapy (NAC) and early decision for surgery in advanced squamous cell carcinoma (SCC) of the maxillary sinus. Objectives: This study aimed to find a possible relation of ERCC1 or XRCC1 expression with response to ...
Goellner Matthias - - 2012
Abstract Objective. The purpose of this clinical study was to evaluate the correlation between tooth mobility (TM), crown-to-root ratio (CRR) and clinical attachment loss (CAL) in periodontally-compromised participants. Materials and methods. While slowly biting on a load cell, the mobility of the upper incisors and canine teeth of 20 volunteers ...
Yumoto Eiji - - 2012
Abstract Conclusions: Three different types of glottal configuration in unilaterally paralyzed larynx were proposed by utilizing three-dimensional computed tomographic (3DCT) images. This new classification might facilitate understanding of the behavior of the affected vocal fold in terms of vocal function. Objectives: To develop a classification of glottal configuration in unilateral ...
Fujii Yuki - - 2012
Characterising the binding mechanism of Bacillus thuringiensis Cry toxin to the cadherin receptor is indispensable to understanding the specific insecticidal activity of this toxin. To this end, we constructed 30 loop mutants by randomly inserting 4 serial amino acids covering all 4 receptor binding loops (loop α8, loop 1, loop ...
Ruths Sabine - - 2012
BACKGROUND: Psychotropic drugs are extensively prescribed for the treatment of neuropsychiatric symptoms, despite modest efficacy and severe side effects. AIMS: We examined trends in psychotropic drug prescribing in Norwegian nursing homes from 1997 to 2009, in order to gain insight in practice development. METHODS: The study is a secondary data ...
He Jun - - 2012
Microcystin-LR (MCLR), a potent hepatotoxin, is causing increasing risk to public health. Although liver is the main target organ of MCLR, the metabolic profiling of liver in response to MCLR in vivo remains unknown. Here, we comprehensively analyzed the metabolic change of liver and ileal flushes in rat orally gavaged ...
Ernst Benjamin J - - 2012
BACKGROUND: To evaluate and compare perfluorocarbon liquid, silicone oil, and viscoelastic to standard saline for their ability to dampen the impact force of a foreign body dropped within the eye. In an experimental surgical model in where cohesive and adhesive forces of the substances are not enough to float heavy-than-water ...
Halland Magnus - - 2012
IBS is a common disorder that affects approximately 5-20% of the populations of Western countries; the main symptoms are abdominal pain and erratic, altered bowel habits, often accompanied by bloating. Despite an array of available pharmacological and nonpharmacological treatments aimed at a wide variety of gastrointestinal and brain targets, many ...
García-Ceca Javier - - 2012
The signals that determine the survival/death of the thymic epithelial cells (TECs) component during embryonic development of the thymus are largely unknown. In this study, we combine different in vivo and in vitro experimental approaches to define the role played by the tyrosine kinase receptors EphB2 and EphB3 and their ...
Flook Nigel W - - 2013
High-quality data regarding the efficacy of acid-suppressive treatment for unexplained chest pain are lacking. The aim of this study was to evaluate the efficacy of esomeprazole in primary-care treatment of patients with unexplained chest pain stratified for frequency of reflux/regurgitation symptoms. Patients with a ≥ 2-week history of unexplained chest ...
Zhou Xiuwen - - 2012
The absorption spectrum of fluorenone in zeolite L is calculated from first-principles simulations. The broadening of each band is obtained from the explicit treatment of the interactions between the chromophore and its environment in the statistical ensemble. The comparison between the simulated and measured spectra reveals the main factors affecting ...
Stevanovic Stephane - - 2012
The absorption of carbon dioxide by the pure ionic liquids 1-ethyl-3-methylimidazolium acetate ([C1C2Im][OAc]) and 1-butyl-3-methylimidazolium acetate ([C1C4Im][OAc]) was studied experimentally from 303 K to 343 K. As expected, the mole fraction of absorbed carbon dioxide is high (0.16 at 303 K and 5.5 kPa and 0.19 at 303 K and ...
Chaplin Emma Jane Louise - - 2012
BACKGROUND: Neuromuscular electrical stimulation (NMES) has shown to improve skeletal muscle strength and exercise capacity in stable patients with chronic obstructive pulmonary disease (COPD). Variations in NMES protocols are considerable. We aimed to compare changes in muscle strength after high-frequency and low-frequency NMES in patients admitted to hospital with an ...
Hazra Soumitra - - 2012
Berberine, palmatine and coralyne, the isoquinoline alkaloids distributed in many botanical families, are extensively investigated due to their potential therapeutic actions and clinical utilities. In this work, their binding characteristics to hemoglobin (Hb) were studied by UV-vis absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy, isothermal calorimetric titration and differential scanning ...
McMahan Zsuzsanna H - - 2012
The management of patients with systemic sclerosis (SSc) can be challenging because disease-associated damage is often difficult to reverse and curative therapies are not yet available. Early identification and appropriate monitoring of patients with SSc is, therefore, critical so that active disease can be controlled and tissue damage prevented or ...
Chang Bor Kae - - 2012
Carbon dioxide adsorption sites within the flexible metal-organic framework (MOF) zinc 1,2-bis(4-pyridyl)ethane tetrafluoroterephthalate (Znbpetpa) were investigated using density functional theory (DFT) and canonical Monte Carlo (MC) calculations. Two types of sites with different heats of adsorption were found by using DFT and confirmed by the MC results. Expansion of the ...
Krisa L - - 2012
Study design:A prospective repeated measures multicenter study to determine reliability at individual spinal levels when applied to young persons with spinal cord injury (SCI).Objectives:To evaluate intra- and inter-rater agreement of repeated motor and sensory scores at individual spinal levels.Setting:Shriners Hospitals for Children-Philadelphia and Chicago, USAMethods:A total 189 youth with complete ...
Thompson Stephanie - - 2012
Background: Computer-based clinical decision support aims to improve the quality of patient care. The utility of decision support for improving blood pressure control in hemodialysis patients is unknown. Methods: This was a nonrandomized controlled trial of adult patients receiving chronic in-center hemodialysis during the period of April 1, 2005, to ...
Guilcher S J T - - 2012
Study design:Retrospective cohort with linkage of administrative data sets.Objectives:To describe the patterns (for example, number of visits by year post-injury) and characteristics of the emergency department (ED) visits (for example, acuity level, timing of visits, reasons for visits) made by persons with traumatic spinal cord injury (TSCI) over a 6-year ...
Wang Qin - - 2012
Interleukin-1 (IL-1) signaling in anchorage-dependent cells involves focal adhesion-restricted and Ca2+-dependent Ras and extracellular signal-related kinase (ERK) activation that lead to MMP release and extracellular matrix remodeling. Ras activity is regulated in part by the Ca2+-responsive Ras guanine-nucleotide-releasing factors 1 and 2 (Ras-GRF1/2), but the mechanisms that link and localize ...
Saar Matthias - - 2012
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: There is evidence from large abdominal surgeries and some open cystectomy series that multifactorial fast-track regimens shorten postoperative convalescence without any effect on morbidity and mortality. Such a regimen is of particular interest in combination with minimally invasive techniques, ...
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