Search Results
Results 201 - 250 of 2469
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Liu Wukun - - 2012
The discovery of cisplatin's antitumor activity in 1969 prompted the search for novel metal-containing complexes as potential anticancer drugs. Among these novel complexes, metal N-heterocyclic carbene (NHC) complexes have recently gained considerable attention because they perfectly fit prerequisites for efficient drug design and fast optimization. Moreover, most of them have ...
Chai Charmaine Hc - - 2012
Optic nerve head swelling after acute primary angle-closure (APAC) has been associated with significant visual loss. We provide the first description of a good visual outcome following transient isolated optic nerve swelling associated with APAC. A 64 year-old man presented with right eye pain and poor vision for a day. ...
Choi Ik Joon - - 2012
Abstract Conclusion: ERCC 1 seems to be promising as a predictive marker for response to neoadjuvant chemotherapy (NAC) and early decision for surgery in advanced squamous cell carcinoma (SCC) of the maxillary sinus. Objectives: This study aimed to find a possible relation of ERCC1 or XRCC1 expression with response to ...
Goellner Matthias - - 2012
Abstract Objective. The purpose of this clinical study was to evaluate the correlation between tooth mobility (TM), crown-to-root ratio (CRR) and clinical attachment loss (CAL) in periodontally-compromised participants. Materials and methods. While slowly biting on a load cell, the mobility of the upper incisors and canine teeth of 20 volunteers ...
Yumoto Eiji - - 2012
Abstract Conclusions: Three different types of glottal configuration in unilaterally paralyzed larynx were proposed by utilizing three-dimensional computed tomographic (3DCT) images. This new classification might facilitate understanding of the behavior of the affected vocal fold in terms of vocal function. Objectives: To develop a classification of glottal configuration in unilateral ...
Flores G - - 2013
Severe obesity has increased >300% in US children since 1976, and is associated with multiple cardiovascular risk factors and high adult obesity rates. The objective of this study was to identify predictors of severe obesity in kindergarteners. Multivariable logistic regression and recursive partitioning analysis (RPA) were used to identify prenatal/pregnancy, ...
Fujii Yuki - - 2012
Characterising the binding mechanism of Bacillus thuringiensis Cry toxin to the cadherin receptor is indispensable to understanding the specific insecticidal activity of this toxin. To this end, we constructed 30 loop mutants by randomly inserting 4 serial amino acids covering all 4 receptor binding loops (loop α8, loop 1, loop ...
Nyholm Spencer V SV Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269, USA. - - 2012
The innate immune system is present in all animals and is a crucial first line of defence against pathogens. However, animals also harbour large numbers of beneficial microorganisms that can be housed in the digestive tract, in specialized organs or on tissue surfaces. Although invertebrates lack conventional antibody-based immunity, they ...
Wang Honggen - - 2012
Taking advantage of Rh(III)-catalyzed C-H activation reactions, we have developed a mild, short and efficient method for the synthesis of bench-stable 3-isoquinolone MIDA boronates. The reaction is practical and scalable. The product formed has been applied in the Suzuki-Miyaura reaction with high efficiency. This strategy has also been successfully expanded ...
Hassel Alexander J - - 2012
Abstract Objectives. Because of its good matching performance the VITA 3D-Master shade guide (3D) is frequently used for determination of tooth color. Numerous composites/ceramics are, however, available in VITA Classical (VC) shades only. The objective of this study was to investigate the possibility of performing a shade match with 3D ...
Srinivasan Sathish - - 2012
The presence of pre-existing corneal opacities during cataract surgery can cause scattering of light from the operating microscope, limiting the surgeon's view of the anterior chamber (AC). In this context, combined corneal transplantation and cataract surgery may be preferential. However, patients with mild to moderate nebulae may prefer to undergo ...
Zuela Noam N Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, - - 2012
Lamins are nuclear intermediate filament proteins. They provide mechanical stability, organize chromatin and regulate transcription, replication, nuclear assembly and nuclear positioning. Recent studies provide new insights into the role of lamins in development, differentiation and tissue response to mechanical, reactive oxygen species and thermal stresses. These studies also propose the ...
Lombardi G - - 2012
Objective:To evaluate the clinical and urodynamic impact of intravesical electrostimulation (IVES) on incomplete spinal cord injury (SCI) patients suffering from chronic neurogenic non-obstructive urinary retention (N-NOR).Methods:One-hundred and two patients underwent at least 28 consecutive daily IVES sessions because objective evidence of detrusor acontractility instead of hypocontractility was detected. Diary entries ...
Maria Spaggiari Grazia - - 2012
In recent years, human mesenchymal stem/stromal cells (MSC) have attracted major attention for their possible clinical applications. In addition to their tissue regenerative capacity, they display immune-modulatory properties for which they have been used in the treatment of acute graft-versus-host disease and autoimmune diseases. Various studies have analyzed the inhibitory ...
Kattel Shyam - - 2012
First-principles DFT computations are performed to explain the origin and the mechanism of oxygen reduction reaction (ORR) on Co-N(x) (x = 2, 4) based self-assembled carbon supported electrocatalysts in alkaline and acidic media. The results show that the formation of graphitic Co-N(4) defect is energetically more favorable than the formation ...
Milles Sigrid - - 2012
While innovations in modern microscopy, spectroscopy, and nanoscopy techniques have made single molecule observation a standard in many laboratories, the actual design of meaningful fluorescence reporter systems now hinders major scientific breakthroughs. Even though the field of chemical biology is supercharging the fluorescence toolbox, surprisingly few strategies exist that make ...
Jones Samuel - - 2012
In Australia's north, the remote island indigenous communities of the Torres Strait have had an uninterrupted ophthalmic service for the last 25 years, usually for 6 weeks per annum. During that time, the leading causes of visual impairment have been cataract, including among those offered but declining surgery, and diabetic ...
Strömberg Ella - - 2012
Abstract Objectives. To describe the oral health-related quality-of-life in homebound elderly dependent on moderate and substantial supportive care for daily living. Materials and methods. A total of 302 selected persons in three counties in Sweden over 65 years of age and in need of daily support from society participated in ...
Cantillo-Baños Enrique - - 2012
Abstract Conclusion: The choice of technique will depend on the glottic gap observed by stroboscopy, the alteration of the Voice Handicap Index (VHI) and the recorded values of harmonics-to-noise ratio (HNR), jitter and shimmer, and the general health, age and underlying pathology. There are statistically significant differences between the values ...
Ansong Charles C Biological Sciences Division, Pacific Northwest National Laboratory, P. O. Box 999, Richland, WA 99352, - - 2013
The underlying mechanisms that lead to dramatic differences between closely related pathogens are not always readily apparent. For example, the genomes of Yersinia pestis (YP) the causative agent of plague with a high mortality rate and Yersinia pseudotuberculosis (YPT) an enteric pathogen with a modest mortality rate are highly similar ...
Chiorazzi Nicholas N Karches Center for Chronic Lymphocytic Leukemia Research, The Feinstein Institute for Medical Research, Hofstra North Shore-LIJ School of Medicine, 350 Community Drive, Manhasset, NY 10030, USA. - - 2013
The significant correlation between disease aggressiveness and the gene and protein structures of the B-cell receptors (BCRs) expressed on chronic lymphocytic leukemia (CLL) cells, together with the evidence for chronic activation of the BCR pathway, have led to the hypothesis that this leukemia initiates and progresses by selecting normal B ...
Cassidy Andrew - - 2012
Data are presented showing the spontaneous formation of electric fields within solid films of the chlorofluorocarbons (CFCs) CF(3)Cl, CF(2)Cl(2) and CFCl(3) as a function of film deposition temperature from 40 K and above. Electric fields, which arise through dipole alignment and lie in the range of a few times 10(7) ...
Greiner Jack V - - 2012
PURPOSE: To determine the 1-year post-treatment dry eye status of subjects with meibomian gland dysfunction (MGD) and dry eye symptoms after receiving a single LipiFlow® Thermal Pulsation System (LTPS) treatment. DESIGN: Single-center, prospective, observational, open-label, 1-month registered clinical trial with a 1-year follow-up examination. PARTICIPANTS: Patients with evaporative dry eye ...
de Raaf P J PJ Department of Medical Oncology, Daniel den Hoed Cancer Center, Erasmus MC, Rotterdam, The Netherlands. - - 2013
Although the multidimensional nature of cancer-related fatigue is widely accepted, it could be questioned whether fatigue dimensions are expressions of one symptom (multidimensional concept) or expressions of several phenomena that are all called fatigue but actually are separate symptoms (multiple-symptom concept). Therefore, we investigated in this review whether physical fatigue ...
Barry W - - 2012
Objectives:Hypertension (HTN) is an important risk factor for cardiovascular disease, a major cause of morbidity and mortality among people with spinal cord injury and disorders (SCI/D). Our study examined prevalence, associated factors, and pharmacological treatment of HTN in Veterans with SCI/D compared with a matched control group.Methods:A retrospective review was ...
Rawlins B G - - 2012
Regulatory authorities need ways to estimate natural terrestrial gamma radiation dose rates (nGy h(-1)) across the landscape accurately, to assess its potential deleterious health effects. The primary method for estimating outdoor dose rate is to use an in situ detector supported 1 m above the ground, but such measurements are ...
Bannert Christina - - 2012
Quality indicators including cecal intubation rate (CIR) and adenoma detection rate (ADR) are established. Sex differences of quality indicators are observed, but the influence of sedation has not been investigated so far. The objective of this study is to assess the impact of sedation on quality indicators, including CIR and ...
Moeller L - - 2012
Abstract Objective. The aim of this study was to compare the presence of voids in root fillings performed in oval and ribbon-shaped canals with two root filling techniques, lateral compaction technique (LCT) or hybrid technique (HT), a combination of a gutta-percha masterpoint and thermoplastic gutta-percha. Furthermore, the obturation time for ...
Lamb Christopher A - - 2012
Two key questions in the autophagy field are the mechanisms that underlie the signals for autophagy initiation and the source of membrane for expansion of the nascent membrane, the phagophore. In this review, we discuss recent findings highlighting the role of the classical endosomal pathway, from plasma membrane to lysosome, ...
Chun So Young - - 2012
This study investigated the differentiation of human amniotic fluid-derived stem cells (hAFSCs) into insulin-producing clusters in vitro. Adenovirally-delivered mouse Pdx1 (Ad-Pdx1) induced human Pdx1 expression in hAFSCs and enhanced the coordinated expression of downstream β-cell markers. When Ad-Pdx1-transduced hAFSCs were sequentially treated with activin A, bFGF and nicotinamide and the ...
Sprangers Ben - - 2012
Relapses or flares of systemic lupus erythematosus (SLE) are frequent and observed in 27-66% of patients. SLE flares are defined as an increase in disease activity, in general, requiring alternative treatment or intensification of therapy. A renal flare is indicated by an increase in proteinuria and/or serum creatinine concentration, abnormal ...
Dani Carlo - - 2012
Abstract Objectives: Our aim was to assess whether non-invasive ventilation with heliox may decrease the incidence of extubation failure in preterm infants with RDS. Methods: Infants <29 weeks of gestation were treated immediately after extubation with heliox combined with nasal continuous airway pressure (Hx-NCPAP) or bilevel NCPAP (Hx-BiPAP) for 24 ...
Ernst Benjamin J - - 2012
BACKGROUND: To evaluate and compare perfluorocarbon liquid, silicone oil, and viscoelastic to standard saline for their ability to dampen the impact force of a foreign body dropped within the eye. In an experimental surgical model in where cohesive and adhesive forces of the substances are not enough to float heavy-than-water ...
Halland Magnus - - 2012
IBS is a common disorder that affects approximately 5-20% of the populations of Western countries; the main symptoms are abdominal pain and erratic, altered bowel habits, often accompanied by bloating. Despite an array of available pharmacological and nonpharmacological treatments aimed at a wide variety of gastrointestinal and brain targets, many ...
García-Ceca Javier - - 2012
The signals that determine the survival/death of the thymic epithelial cells (TECs) component during embryonic development of the thymus are largely unknown. In this study, we combine different in vivo and in vitro experimental approaches to define the role played by the tyrosine kinase receptors EphB2 and EphB3 and their ...
Camilleri Michael M Department of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA. - - 2013
This guideline presents recommendations for the evaluation and management of patients with gastroparesis. Gastroparesis is identified in clinical practice through the recognition of the clinical symptoms and documentation of delayed gastric emptying. Symptoms from gastroparesis include nausea, vomiting, early satiety, postprandial fullness, bloating, and upper abdominal pain. Management of gastroparesis ...
Park Chungoo C Department of Ecology and Evolutionary Biology, University of Michigan, 1075 Natural Science Building, 830 North University Avenue, Ann Arbor, Michigan 48109, - - 2012
Reporter gene assays have demonstrated both transcription-associated mutagenesis (TAM) and transcription-coupled repair, but the net impact of transcription on mutation rate remains unclear, especially at the genomic scale. Using comparative genomics of related species as well as mutation accumulation lines, we show in yeast that the rate of point mutation ...
Sternberg Itay A - - 2012
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Bladder cancer patients with lamina propria invasion (T1 disease) and residual T1 disease on restaging transurethral resection of bladder tumour (re-TURBT) are at a very high risk for recurrence and progression. Despite this risk, most patients are treated with ...
Teng Jingfei - - 2013
To assess the overall efficacy and safety of photoselective vaporization of the prostate (PVP) vs transurethral resection of the prostate (TURP) for treating patients with lower urinary tract symptoms (LUTS) secondary to benign prostate hyperplasia (BPH). A systematic search of the electronic databases, including MEDLINE, Embase, Web of Science and ...
Briganti Alberto - - 2012
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Previous studies have retrospectively compared functional and oncological outcomes between robot-assisted radical prostatectomy (RARP) and open retropubic radical prostatectomy (RRP), reporting non-inferior or superior outcomes associated with the use of the robotic approach. The study demonstrates that baseline selection ...
Sugitani Ai - - 2012
Selective anodic stripping voltammetry of trace metal ions in a mixture solution with another interfering metal was developed based on Fick's law concerning the diffusion profile of interfering metals at the electrode surface after electrolysis treatment. A boron-doped diamond film was used as the sensing electrode, while a perforated carbon ...
Bottini Nunzio N Division of Cellular Biology, La Jolla Institute of Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, - - 2013
Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key component of this invasive synovium and have a major role in the initiation and perpetuation of destructive joint inflammation. The pathogenic potential of FLS in RA stems ...
Hiatt Kelly - - 2012
Muscle progenitor cells (MPCs) are currently being investigated as cellular vectors to deliver neurotrophic factor (NF) for the promotion of re-innervation after axonal injury. Ideally NF delivery in such a model would enhance axonal regeneration while simultaneously promoting MPC viability. To date, insulin-like growth factor 1 (IGF-1) is one of ...
Gez Liron Suzanne - - 2012
The activation of the ryanodine Ca2+-release channels (RyR2) by Ca2+ entry through the L-type Ca2+-channels (Cav1.2) is believed to be the primary mechanism of Excitation-Contraction (EC) coupling in cardiac cells. This proposed mechanism of Ca2+-induced-Ca2+-release (CICR), cannot fully account for the lack of a termination signal for this positive feedback ...
Jackson Andrew - - 2012
Regaining motor function is of high priority to patients with spinal cord injury (SCI). A variety of electronic devices that interface with the brain or spinal cord, which have applications in neural prosthetics and neurorehabilitation, are in development. Owing to our advancing understanding of activity-dependent synaptic plasticity, new technologies to ...
Seyed-Razavi Yashar - - 2012
Membrane nanotubes (MNTs) are newly discovered cellular extensions that are either blind-ended or can connect widely separated cells. They have predominantly been investigated in cultured isolated cells, however, previously we were the first group to demonstrate the existence of these structures in vivo in intact mammalian tissues. We previously demonstrated ...
He Jun J State Key Lab of Reproductive Medicine, Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing 210029, PR - - 2012
Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR-199a and miR-125b target ERBB2 and/or ERBB3 in ovarian cancer cells, and ...
Wang Qin - - 2012
Interleukin-1 (IL-1) signaling in anchorage-dependent cells involves focal adhesion-restricted and Ca2+-dependent Ras and extracellular signal-related kinase (ERK) activation that lead to MMP release and extracellular matrix remodeling. Ras activity is regulated in part by the Ca2+-responsive Ras guanine-nucleotide-releasing factors 1 and 2 (Ras-GRF1/2), but the mechanisms that link and localize ...
Nanda Kavinderjit S KS Center for Inflammatory Bowel Disease, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, - - 2013
Antibodies to infliximab (ATIs) have been associated with loss of clinical response and lower serum infliximab (IFX) levels in some studies of patients with inflammatory bowel disease (IBD). This has important implications for patient management and development of novel biologic therapies. The objective of this study was to perform a ...
Chen C - - 2012
Schizophrenia (SCZ) and bipolar disorder (BD) are highly heritable psychiatric disorders. Associated genetic and gene expression changes have been identified, but many have not been replicated and have unknown functions. We identified groups of genes whose expressions varied together, that is co-expression modules, then tested them for association with SCZ. ...
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