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Mazor Yuval Y Department of Biochemistry and Molecular Biology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, - - 2012
Recent structural determinations and metagenomic studies shed light on the evolution of photosystem I (PSI) from the homodimeric reaction centre of primitive bacteria to plant PSI at the top of the evolutionary development. The evolutionary scenario of over 3.5 billion years reveals an increase in the complexity of PSI. This ...
Semchonok Dmitry A DA Electron Microscopy Group, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 7, Groningen, The - - 2012
Electron microscopy and single-particle averaging were performed on isolated reaction centre (RC)-antenna complexes (RC-LH1-PufX complexes) of Rhodobaca bogoriensis strain LBB1, with the aim of establishing the LH1 antenna conformation, and, in particular, the structural role of the PufX protein. Projection maps of dimeric complexes were obtained at 13 Å resolution ...
Mitra Mautusi M Department of Plant and Microbial Biology, University of California-Berkeley, CA 94720, - - 2012
Truncated light-harvesting antenna 1 (TLA1) is a nuclear gene proposed to regulate the chlorophyll (Chl) antenna size in Chlamydomonas reinhardtii. The Chl antenna size of the photosystems and the chloroplast ultrastructure were manipulated upon TLA1 gene over-expression and RNAi downregulation. The TLA1 over-expressing lines possessed a larger chlorophyll antenna size ...
Tikkanen Mikko M Molecular Plant Biology, Department of Biochemistry and Food Chemistry, University of Turku, Turku, - - 2012
Safe and efficient conversion of solar energy to metabolic energy by plants is based on tightly inter-regulated transfer of excitation energy, electrons and protons in the photosynthetic machinery according to the availability of light energy, as well as the needs and restrictions of metabolism itself. Plants have mechanisms to enhance ...
Lee Roland Y RY Department of Ophthalmology, University of California-San Francisco, CA 94143, - - 2013
To determine the association between ethnicity and changes in intraocular pressure and anterior segment biometric parameters following cataract surgery by phacoemulsification in nonglaucomatous subjects. Prospective clinical cohort study. Caucasian and Asian subjects. Customized software was used to calculate parameters from anterior segment optical coherence tomography images obtained preoperatively and at ...
Almeida Dalziza Victalina DV AIDS and Molecular Immunology Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil. - - 2013
Tests for the detection of the humoral immune response to HIV-1 have to be standardized and established, demanding regional efforts. For this purpose the neutralizing antibody (NAb) assay for HIV-1 in TZM-bl cells was introduced in Brazil. Twenty plasma samples from HIV-1-infected individuals were assayed: 10 progressors and 10 long-term ...
Westra Edze R - - 2012
All organisms need to continuously adapt to changes in their environment. Through horizontal gene transfer, bacteria and archaea can rapidly acquire new traits that may contribute to their survival. However, because new DNA may also cause damage, removal of imported DNA and protection against selfish invading DNA elements are also ...
Daugherty Matthew D - - 2012
Mammalian genes and genomes have been shaped by ancient and ongoing challenges from viruses. These genetic imprints can be identified via evolutionary analyses to reveal fundamental details about when (how old), where (which protein domains), and how (what are the functional consequences of adaptive changes) host-virus arms races alter the ...
Byers Peter H - - 2012
More than 90% of people who have osteogenesis imperfecta (OI) have heterozygous mutations in one of the two type I collagen genes, COL1A1 and COL1A2. The effects of these changes range from death in the perinatal period to barely increased fracture frequency and reflect different types of mutations. Introduction of ...
Kalsdorf Barbara B Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa. - - 2013
Increased susceptibility to tuberculosis following HIV-1 seroconversion contributes significantly to the tuberculosis epidemic in sub-Saharan Africa. Lung-specific mechanisms underlying the interaction between HIV-1 and Mycobacterium tuberculosis infection are incompletely understood. Here we address these questions by examining the effect of HIV-1 and latent M. tuberculosis co-infection on the expression of ...
Castaldo Imma I Department of Cellular and Molecular Biology and Pathology, University of Naples "Federico II," Naples, Italy. - - 2013
Enhanced oxidative stress and inflammation contribute to telomere erosion. Friedreich's ataxia is a neurodegenerative disorder caused by a reduction in frataxin expression that results in mitochondrial dysfunction and oxidative damage. Furthermore, frataxin deficiency induces a strong activation of inflammatory genes and neuronal death. We investigated telomere length (TL) in peripheral ...
Sidhu Davinder - - 2012
Although current guidelines recommend measuring lipid levels in a fasting state, recent studies suggest that nonfasting lipid profiles change minimally in response to food intake and may be superior to fasting levels in predicting adverse cardiovascular outcomes. The objective of this study was to investigate the association between fasting times ...
Eisenreich Karen M - - 2013
Polybrominated diphenyl ethers (PBDEs) are a bioaccumulative, persistent, and toxic class of flame retardants that can potentially impact turtles in natural habitats via exposure through maternal transfer. To simulate maternal transfer in the present study, PBDE congeners BDE-47 and BDE-99 were topically applied to the eggshell and were allowed to ...
Hillman Robert D RD Jr Department of Microbiology, The University of Chicago, 920 East 58th Street, Cummings Life Sciences Center 707A, Chicago, IL 60637, - - 2013
Rickettsia conorii, a member of the spotted fever group (SFG) of the genus Rickettsia and causative agent of Mediterranean spotted fever, is an obligate intracellular pathogen capable of infecting various mammalian cell types. SFG rickettsiae express two major immunodominant surface cell antigen (Sca) proteins, OmpB (Sca5) and OmpA (Sca0). While ...
Kemp Alain J AJ Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, - - 2013
In Saccharomyces cerevisiae, the SUP70 gene encodes the CAG-decoding tRNA(Gln)(CUG). A mutant allele, sup70-65, induces pseudohyphal growth on rich medium, an inappropriate nitrogen starvation response. This mutant tRNA is also a UAG nonsense suppressor via first base wobble. To investigate the basis of the pseudohyphal phenotype, 10 novel sup70 UAG ...
Corti R - - 2012
The introduction of bare metal stents in the early 1990 and of 1st generation drug eluting stents (DES) in the early 2000 defined a new era in interventional cardiology. DES dramatically reduced instent restenosis and the need of revascularization after percutaneous coronary intervention. However, this increased efficacy came at the ...
Mohamed-Ahmed Abeer H A - - 2012
Amphotericin B (AmpB) is considered the first-line treatment for visceral leishmaniasis in areas in which resistance to antimony is prevalent. This review describes recent advances in clinically available and novel drug delivery systems of AmpB to treat visceral leishmaniasis. Over the past two decades, lipid-based AmpB formulations developed to tackle ...
Franko Orrin I - - 2012
: Surgeons and software developers recognize that apps can improve patient care by replicating the function of existing medical devices. However, the incorporation of new tools requires that the clinical data being recorded is accurate and valid. This study attempts to validate a new iPhone app to measure scoliotic rotation. ...
Bassareo Pier P - - 2012
In a univentricular heart corrected with a Fontan repair (UVH-F), a single pumping chamber is responsible for both systemic and pulmonary circulations. To evaluate the influence of afterload on cardiac output (CO) of UVH-F, this study aimed at (a) evaluating 24-h ambulatory blood pressure monitoring (ABPM) data of a group ...
Griffin Justin W - - 2012
Use of antibiotic-impregnated spacers is common in the two-stage approach to treatment of periprosthetic joint infection despite the lack of information regarding in vivo performance of these implants. Antibiotic elution levels likely often fall below the minimal inhibitory concentration need to inhibit bacterial growth, raising concern that the spacers themselves ...
Türker Mehmet - - 2012
This study aims to test the efficacy of magnetic resonance imaging (MRI) evaluation by a group who were blinded to the arthroscopic diagnosis in patients with known bucket handle meniscal tears. In this study, MRI scans of 28 patients who were operated due to bucket handle meniscal tear with sufficient ...
Greiwe Raymond Michael - - 2012
: Voluntary shoulder instability is characterized by a patient's ability to sublux their shoulder using selective muscle contraction and relaxation. High failure rates exist with open shoulder stabilization in this group of patients. The purpose of this study was to report the outcomes for patients with voluntary instability treated arthroscopically. ...
McComb Neil - - 2012
Competing in triathlons requires a lot of training, often under less than ideal conditions. Tips for training in the cold and rain are outlined in this review.
Nanda S - - 2012
Hypertrophic cardiomyopathy (HCM) occurs in 1 in every 500 individuals. It represents the most common cause of sudden cardiac death in those under the age of twenty-five. 3-5% patients with HCM go on to develop the dilated, hypokinetic end stage (ES) HCM with systolic failure. They have a higher incidence ...
Metkar Umesh - - 2012
: This case provides a rare occurrence of a giant cell tumor (GCT) in posterior elements of a lumbar vertebra in a 7-year-old child with successful outcome after surgical excision and regular follow-ups. : To present a unique case report of a pediatric GCT in the vertebral column and results. ...
Haugan Gørill - - 2012
Aims and objectives.  The aim of this study was to test whether nurse-patient interaction affects cognitively intact nursing home patients' interpersonal and intrapersonal self-transcendence, as well as testing the psychometric properties of the Nurse-Patient Interaction Scale (NPIS). Background.  Self-transcendence is considered a spiritual developmental process of maturity in adulthood, and ...
Görmeli Gökay - - 2012
This study aims to investigate the clinical profile and prognosis of the patients with fasciotomy who were admitted to Van Training and Research Hospital following the 2011 Van earthquake. Twenty-one patients (11 males, 10 females; mean age 38.3 years; range 18 to 60 years) who had urgent fasciotomy in our ...
Bowen Richard E - - 2012
Patient-based outcome measures are important tools quantifying the disease-specific and/or global quality of life (QOL) effects of spinal deformity treatment. In patients with neuromuscular disorders such as cerebral palsy, muscular dystrophy, and myelomeningocele, treatment effects must be differentiated from underlying disease functional impairments. In general, the goals of spinal surgery ...
Wright Vonda J - - 2012
Current endurance champions are turning in winning performances in their late 30s and 40s. These masters-age athletes present a special challenge to Sport Medicine practitioners who in previous decades have simply advised masters-aged athletes to stop competing to prevent or treat injury. The fact is, many of the physical changes ...
Norouzi Kian - - 2012
To explore rehabilitation care process in patients who commit self-immolation. Self-immolation is not only a type of burn injury, but it is also a suicidal method. It is placed in burn injury category that requires long-term rehabilitation and treatment measures. As a suicidal method, among all forms of suicidal attempts, ...
Qin Guangcheng - - 2012
Migraine is a refractory disease that is due to neuronal hyperexcitability, and has high incidence, mortality, and disability rates. The N-methyl-D-aspartate receptor 2B (NR2B) subunit has been found to play an important role in the pathogenesis of migraine. There is evidence suggesting that a tumor suppressor phosphatase and tensin homolog ...
Bales James - - 2012
Most triathlon overuse injuries occur due to the running and cycling aspects of the sport. By nature of swimming being a non-weight-bearing sport, triathletes have a tendency to use swimming for rehabilitation and recovery. Swimming has a significantly lower injury rate than the other 2 disciplines in a triathlon. Most ...
Ibrahim Talal - - 2012
: The purpose of our study was to evaluate the effectiveness of treating extremity aneurysmal bone cysts (ABC) by percutaneous curettage compared with open intralesional excision. : A retrospective review of 17 patients with histologically proven primary ABCs and no evidence of a secondary lesion treated either by percutaneous curettage ...
Chen Shiu-Jau - - 2012
Neurogenesis via the activation of endogenous neural progenitor cells is a potential treatment strategy for brain injury, including intracerebral hemorrhage (ICH). We assessed the efficacy of combined cell and brain-derived neurotrophic factor (BDNF) treatment in a mouse model of ICH induced by intracerebral collagenase injection. Complementary DNAs of mouse BDNF ...
La Rocca Andres Pascual - - 2012
PURPOSE:: Periodontal biotype is considered to be a significant factor related to successful dental treatments. The purpose of this study was to determine the relationship between gingival thickness (GT) and width with respect to the underlying bone thickness in the maxillary and mandibular anterior sextant. MATERIALS AND METHODS:: Overall, 180 ...
Sterzenbach Guido - - 2012
This is the first clinical long-term pilot study that tested the biomimetic concept of using more flexible, dentine-like (low Young modulus) glass fiber-reinforced epoxy resin posts (GFREPs) compared with rather rigid, stiff (higher Young modulus) titanium posts (TPs) in order to improve the survival rate of severely damaged endodontically treated ...
Litzelmann Estelle - - 2012
: Thirty to 60% of hereditary multiple exostoses patients have forearm deformities. There is no consensus regarding optimal therapy. This long-term retrospective study is the first to compare radiologic and clinical data with patient assessments, to define more precise surgical indications. : All children presenting with hereditary multiple exostose during ...
Stinson Matthew E T - - 2012
Abstract A series of dams on the Deschutes River, Oregon, act as migration barriers that segregate the river system into upper and lower basins. Proposed fish passage between basins would reunite populations of native potamodromous fish and allow anadromous fish of Deschutes River origin access to the upper basin. We ...
Engström Pähr - - 2012
: Idiopathic toe-walking (ITW) is a condition in which otherwise healthy children walk on their toes. The diagnosis is a diagnosis of exclusion. The aim of this study was to elucidate the occurrence of neuropsychiatric symptoms among 5- to 13-year-old children with ITW. : Fifty-one consecutive children (31 boys, 20 ...
D'Alessandro R - - 2012
Factors that compete to establish heart failure (HF) are not completely known. In the last years the several technological improvements allowed us to deeply study the molecular and genetic aspects of this complex syndrome. This new approach to HF based on molecular biology new discoveries shows us more clearly the ...
Bastien Marjorie - - 2012
Cardiovascular risk profiles and adiposity assessment data in patients with thoracic aortic disease (TAD) are sparse. Despite the fact that TAD patients are considered as a high-risk population, they will not be managed as aggressively as they should in terms of their cardiovascular risk profile. Anthropometric, blood pressure (BP) data, ...
Ting Nicholas T - - 2012
We performed a prospective, randomized clinical trial to evaluate the efficacy of using a bidirectional barbed suture compared with traditional sutures in the deep closure of primary total hip (25) and knee (35) arthroplasties. Complications, time to closure, and length of surgery were evaluated. Closure was noted to be significantly ...
Mendonça D M F - - 2012
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of unknown aetiology. Diagnosis is made through physical examination, electrophysiological findings, and by excluding other conditions. There is not a single biomarker that concludes the diagnosis. The aim of this study was to investigate differentially expressed proteins in cerebrospinal fluid (CSF) ...
Aydin M - - 2012
Cardiac dyssynchrony is a well known entity in patients with wide QRS complex (>120 ms). Dyssynchrony may also cause ventricular dysfunction in heart failure patients with narrow QRS complexes. In the study, the presence and extent of cardiac dyssynchrony were investigated in patients with heart failure both with narrow and ...
Issın Ahmet - - 2012
In this study, we aimed to evaluate the components of knee varus in the adjacent joints and to investigate the possible correlations between them. Between January 2005 and December 2010, 315 lower limbs of 164 patients who underwent high tibial osteotomy (HTO) due to varus gonarthrosis were analyzed. Alignment and ...
Schub David L - - 2012
: Magnetic resonance imaging (MRI) is a commonly used tool for the diagnosis of intra-articular knee pathologies. Although many studies have reported the accuracy of MRI in the adult population, fewer studies have investigated these tests in younger patients. Furthermore, these studies have shown a higher variability in both the ...
Bales James - - 2012
The sport of triathlon offers athletes the chance to build and/or maintain cardiovascular fitness across 3 endurance disciplines. Swimming, biking, and running each have a host of overuse injuries that can occur as a result of overtraining. High running mileage, a history of previous injury, inadequate warm up or cool ...
Akkaya Nuray - - 2012
This study aims to assess pain, functional status, patient satisfaction, and quality of life in patients with proximal row carpectomy. Between December 2007 and November 2011, demographic, clinical, and operational data, and physical therapy program of 16 patients (11 males, 5 females; mean age 41.4±16.6 years; range 19 to 77 ...
Purling Amy - - 2012
To explore the research literature that provided data on factors that influence new graduate nurse's preparedness for recognition and response to patient deterioration in the acute care setting. Nurses have a significant role in recognising subtle signs of patient deterioration and responding appropriately to prevent adverse events and improve patient ...
Abbasi David - - 2012
: Physical examination may be inconclusive in adolescents presenting with an acute traumatic knee effusion because of pain and guarding. The purpose of this study was to describe the magnetic resonance imaging (MRI) findings in adolescents with traumatic knee effusions and to compare injuries based on age, sex, and physeal ...
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