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Chen Zheng W ZW Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine Chicago, Chicago, IL 60612, USA. - - 2013
Vγ2Vδ2 T (also known as Vγ9Vδ2 T) cells exist only in primates, and in humans represent a major γδ T-cell sub-population in the total population of circulating γδ T cells. Results from recent studies suggest that while (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) phosphoantigen from Mycobacterium tuberculosis (Mtb) and other microbes activates and ...
Lewis Sue - - 2012
This research article on youth smoking in disadvantaged communities is the product of a qualitative study to understand the issues faced by young smokers - and those trying not to be smokers - in such communities. Environmental factors and peer influence are widely recognised influences on adolescents' take-up and continuation ...
Nayak Jennifer L JL Department of Pediatrics, Department of Pediatrics, Division of Infectious Diseases, University of Rochester Medical Center, Rochester, NY 14642, USA. - - 2013
The ability of influenza vaccines to elicit CD4(+) T cells and the relationship between induction of CD4(+) T cells and vaccine-induced neutralizing antibody responses has been controversial. The emergence of swine-origin 2009 pandemic influenza A virus subtype H1N1 (A[H1N1]pdm09) provided a unique opportunity to examine responses to an influenza vaccine ...
Wen J J Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, - - 2013
In response to ionizing radiation, the MRE11/RAD50/NBN complex re-distributes to the sites of DNA double-strand breaks (DSBs) where each of its individual components is phosphorylated by the serine-threonine kinase, ATM. ATM phosphorylation of NBN is required for the activation of the S-phase checkpoint, but the mechanism whereby these phosphorylation events ...
Viles-Gonzalez Juan F - - 2012
AIMS: Although complex fractionated atrial electrograms (CFAEs) are purported to represent critical sites for atrial fibrillation (AF) perpetuation, the mechanism and the significance of CFAE in the genesis of AF remain poorly understood. This study evaluated the relationship between CFAE and areas of abnormal atrial tissue defined by low-voltage electrograms ...
Qu Wei - - 2012
Gene therapy offers a bright future for the treatment of cancers. One of the research highlights focuses on smart gene delivery vectors with good biocompatibility and tumor-targeting ability. Here, a novel gene vector self-assembled through avidin-biotin interaction with optimized targeting functionality, biotinylated tumor-targeting peptide/avidin/biotinylated cell-penetrating peptide (TAC), was designed and ...
Nicholls Stuart G - - 2012
OBJECTIVE:In the United Kingdom, newborn blood spot screening proceeds on the basis of consent based on an informed choice. However, little is known about parent experiences of this process. This study was intended to explore parents' understanding of newborn screening and their experience of the consent process using a structured ...
Linardou Helena - - 2012
ABSTRACT: INTRODUCTION: The main prognostic variables in early breast cancer are tumor size, histological grade, ER/PgR status, number of positive nodes and HER2 status. The present study evaluated the prognostic and/or predictive value of VEGF family members in high-risk early breast cancer patients treated with adjuvant chemo-hormonotherapy. METHODS: RNA was ...
Soldati Chiara - - 2012
Huntingtin (Htt) protein interacts with many transcriptional regulators, with widespread disruption to the transcriptome in Huntington's disease (HD) brought about by altered interactions with the mutant Htt (muHtt) protein. Repressor Element-1 Silencing Transcription Factor (REST) is a repressor whose association with Htt in the cytoplasm is disrupted in HD, leading ...
Gray Warren D - - 2012
Dendrimers feature a defined number of terminal groups that may bind RNA or be functionalized with bioactive molecules. These competing uses of terminal groups may create an impasse if the requisite density of ligands depletes the number of terminal groups for binding sufficient RNA, or vice versa. A novel dendrimeric ...
Zhang Hua - - 2012
An intertidal sample of the Australian marine brown alga, Zonaria spiralis, exhibited promising kinase inhibitory and antibacterial activity. Chemical analysis returned six phloroglucinol-derived lipids, the new hemiketal spiralisones A-D () and the known chromones , and the known norsesquiterpenoid apo-9'-fucoxanthinone (). Structures were assigned on the basis of detailed spectroscopic ...
Hansen Sven - - 2012
Water reduction systems that use a bis-cyclometalated Ir(III) photosensitiser (PS) along with homogeneous Pd complexes as a source of in-situ-formed colloidal Pd as the water reducing complex (WRC) and triethylamine (TEA) as the sacrificial electron donor were tested and characterised with respect to their photocatalytic H(2) production performance. It was ...
Guo Fu-Sheng - - 2012
The large cryogenic magnetocaloric effect of a 3D oxydiacetate-bridged gadolinium-manganese MOF material, [Mn(H(2)O)(6)][MnGd(oda)(3)](2)·6H(2)O (), was evaluated by magnetization and heat capacity measurements. A maximum -ΔS(m) of 50.1 J kg(-1) K(-1) for ΔH = 70 kG along with significant entropy change at lower field was found on account of the weak ...
Treviño Jeanette J Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas, - - 2013
The bacterial pathogen group A Streptococcus (GAS) causes human diseases ranging from self-limiting pharyngitis (also known as strep throat) to severely invasive necrotizing fasciitis (also known as the flesh-eating syndrome). To control virulence factor expression, GAS utilizes both protein- and RNA-based mechanisms of regulation. Here we report that the transcription ...
Cruz Breno Fiúza - - 2012
Introduction. Interview-based scales can be used as coprimary measures to complement the assessment of cognitive impairment in schizophrenia. One major question that arises from the use of such tools is how specific they are in relation to other psychopathological domains. We analyse the specificity of the Positive and Negative Syndrome ...
Fallon Jesse A - - 2012
Oil-induced oxidative injury to red blood cells results in Heinz body hemolytic anemia. Here, the authors evaluated three Heinz body staining techniques in brown pelican (Pelecanus occidentalis) blood. Using a range of in vitro acetylphenylhydrazine incubations, the authors validated a field-adapted technique against laboratory wet-mounts and verified the stability of ...
Mason M J - - 2013
Tympanic middle ears have evolved multiple times independently among vertebrates, and share common features. We review flexibility within tympanic middle ears and consider its physiological and clinical implications. The chain of conducting elements is flexible: even the 'single ossicle' ears of most non-mammalian tetrapods are functionally 'double ossicle' ears due ...
Lord Gillian - - 2012
Total arsenic and four arsenic species; arsenite (iAs(III)), arsenate (iAs(V)), dimethylarsinic acid (DMA(V)) and monomethylarsonic acid (MA(V)), are reported in 28 geothermal features from the Taupo Volcanic Zone (TVZ) and Waikato region of New Zealand. Samples were collected for arsenic speciation analysis via a solid phase extraction (SPE) kit allowing ...
Chauviac François-Xavier FX Crystallography, Institute for Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London, WC1E 7HX, United - - 2012
This paper presents the structure of MsAcg (MSMEG_5246), a Mycobacterium smegmatis homologue of Mycobacterium tuberculosis Acg (Rv2032) in its reduced form at 1.6 Å resolution using x-ray crystallography. Rv2032 is one of the most induced genes under the hypoxic model of tuberculosis dormancy. The Acg family turns out to be ...
Villeneuve Céline - - 2012
Two bacterial strains, designated JAM1T and JAM7T, were isolated from a methanol-fed denitrification system treating seawater at the Montreal Biodome, Canada. They were affiliated within the Methylophaga genus of the Gammaproteobacteria by analysis of the 16S ribosomal RNA gene sequences. Strain JAM1T has the capacity to grow under denitrifying conditions ...
Eyet Nicole - - 2012
The gas-phase reactions of F(-)(DMSO), F(-)(CH(3)CN), and F(-)(C(6)H(6)) with t-butyl halides were investigated. Reaction rate constants, kinetic isotope effects, and product ion branching ratios were measured using the flowing afterglow selected ion flow tube technique (FA-SIFT). Additionally, the structure of F(-)(DMSO) was investigated both computationally and experimentally, and two stable ...
Kamakura Naoto - - 2012
Hydroxyl radicals generate a broad range of DNA lesions in living cells. Cyclopurine deoxynucleosides (cPu) are a biologically significant class of oxidative DNA lesions due to their helical distortion and chemically stability. The cPu on DNA are substrates for the nucleotide excision repair (NER), but not for base excision repair ...
Zhang Mao M Stem Cell Transplantation and Cellular Therapy, Surgical Oncology, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, - - 2013
Immunotherapy targeting aberrantly expressed leukemia-associated antigens has shown promise in the management of acute myeloid leukemia (AML). However, because of the heterogeneity and clonal evolution that is a feature of myeloid leukemia, targeting single peptide epitopes has had limited success, highlighting the need for novel antigen discovery. In this study, ...
Batisai Eustina - - 2012
Mechanochemical synthesis has been used to obtain two Werner complexes and their solid solution that could not be obtained by conventional "wet" chemistry; remarkably, despite the structural and chemical similarity, the solid solution exhibits sorption properties that differ from those of the pure compounds.
Haberberger Michael - - 2012
An iron-catalyzed hydroboration of alkynes to produce vinylboronates has been examined. With a straightforward system composed of iron carbonyls and pinacolborane, good to excellent yields and chemoselectivities were achieved for a variety of alkynes.
Wang Lei - - 2012
Despite the reports of the occurrence of bisphenol A diglycidyl ether (BADGE) and its derivatives in canned foods and consumer products, biomonitoring studies of human exposure to these compounds are lacking. In this study, 127 urine samples collected from the U.S. and China were analyzed for free and total (free ...
Salman Shaima S Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, - - 2013
At birth, rat adrenomedullary chromaffin cells (AMCs) respond directly to asphyxial stressors such as hypoxia and hypercapnia by triggering catecholamine secretion, which is critical for proper transition to extrauterine life. These non-neurogenic responses are suppressed postnatally in parallel with the development of splanchnic innervation, and reappear following denervation of the ...
Page Stephen J - - 2012
Objective:To compare the efficacy of a repetitive task-specific practice regimen integrating a portable, electromyography-controlled brace called the 'Myomo' versus usual care repetitive task-specific practice in subjects with chronic, moderate upper extremity impairment.Subjects:Sixteen subjects (7 males; mean age 57.0 ± 11.02 years; mean time post stroke 75.0 ± 87.63 months; 5 ...
El-Kirat-Chatel Sofiane - - 2012
Knowledge of the molecular bases underlying the interaction of fungal pathogens with immune cells is critical to our understanding of fungal infections and offers exciting perspectives for controlling immune responses for therapy. Although fluorescence microscopy is a valuable tool to visualize pathogen-host interactions, the spatial resolution is low, meaning the ...
Menaut P - - 2012
OBJECTIVES: To assess the influence of thyroid function on natriuretic peptide concentration in hyperthyroid cats before and after treatment. METHODS: Serum natriuretic peptide concentration was measured in 61 hyperthyroid cats recruited from first-opinion clinics before and after treatment. RESULTS: Following successful treatment, total thyroxine, heart rate, systolic blood pressure and ...
Carter Stacey C - - 2012
Abstract Technique for apical dissection and control of the dorsal vein complex (DVC) during robot-assisted laparoscopic radical prostatectomy (RALP) affects blood loss, apical positive margins, and recovery of urinary control. Over the past 7 years, our technique for apical dissection has been spurred by the overarching goal of minimizing injury ...
Menon Prahlad G - - 2012
Apicocaval juxtaposition (ACJ) is a rare congenital heart defect associated with single ventricle physiology where optimal positioning of the Fontan conduit for completion of total cavopulmonary connection (TCPC) is still controversial. In ACJ, the cardiac apex is ipsilateral with the inferior vena cava (IVC), risking kinking and collapse of the ...
Wright Laura E LE Endocrinology Section, Department of Medicine, The University of Arizona, Tucson, Arizona 85724, - - 2013
Effects of curcuminoids on breast cancer cell secretion of the bone-resorptive peptide parathyroid hormone-related protein (PTHrP) and on lytic breast cancer bone metastasis were evaluated. In vitro, transforming growth factor (TGF)-β-stimulated PTHrP secretion was inhibited by curcuminoids (IC50 = 24 μM) in MDA-MB-231 human breast cancer cells independent of effects ...
Adams-Sapper Sheila - - 2013
Multidrug-resistant Escherichia coli strains belonging to a single lineage frequently account for a large proportion of extraintestinal E. coli infections in many parts of the world. However, limited information exists on the community prevalence and clonal composition of drug-susceptible E. coli strains. Between July 2007 and September 2010, we analyzed ...
Taguchi Fumiko - - 2012
Virulence factor regulator (Vfr) is a member of the cyclic 3',5'-adenosine monophosphate (cAMP) receptor proteins that regulate the expression of many important virulence genes in Pseudomonas aeruginosa. The role of Vfr in pathogenicity has not been elucidated fully in phytopathogenic bacteria. To investigate the function of Vfr in Pseudomonas syringae ...
Lancaster David L DL Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. - - 2013
Prions are proteins that can adopt different infectious conformations known as "strains" or "variants," each with a distinct, epigenetically inheritable phenotype. Mechanisms by which prion variants are determined remain unclear. Here we use the Saccharomyces cerevisiae prion Rnq1p/[PIN(+)] as a model to investigate the effects of chaperone proteins upon prion ...
Choi Ahyoung - - 2012
Gram-negative strains, motile by a single polar flagellum, non-pigmented and with a curved rod-shaped morphology, designated IMCC1826T and IMCC1883, were isolated from a surface seawater sample of the Yellow Sea. The two strains shared 99.9 % 16S rRNA gene sequence similarity and showed 92 % DNA-DNA relatedness, suggesting that they ...
Rajagopalan Ashwyn - - 2012
BACKGROUND: Merkel cell carcinoma (MCC) is a rare neuroendocrine cancer of the skin. The utility of CD99 (MIC-2) in the diagnosis of MCC has been previously studied, with reported rates of expression ranging from 13 to 55%. When specified, a membranous or cytoplasmic staining pattern was considered significant. Recent studies ...
Burns E M - - 2012
BACKGROUND: This study aimed to describe national intermediate-term admission rates for incisional hernia or clinically apparent adhesions following colorectal surgery, and to compare rates following laparoscopic and open approaches. METHODS: Patients undergoing primary colorectal resection between 2002 and 2008 were included from the Hospital Episode Statistics database. Subsequent inpatient admissions ...
Omar Ns - - 2012
OBJECTIVE: To evaluate the effect of suggesting coitus as a safe and effective means to expedite labour on pregnancy duration and requirement for labour induction. DESIGN: A randomised trial. SETTING: Antenatal clinic in a university hospital in Malaysia. POPULATION: Women from 35 weeks of gestation with an uncomplicated singleton pregnancy. METHODS: ...
Takami Takeshi - - 2012
Objectives The study aimed to evaluate the effectiveness of intravenous indomethacin (IND) therapy for patent ductus arteriosus (PDA) in neonates with genetic disorders and/or congenital anomalies soon after birth.Study Design A total of 301 neonates with a genetic disorder and/or congenital anomalies and with a gestational age of ≥35 weeks were admitted ...
Warren Cirle A - - 2013
Antibiotic treatment, including vancomycin, for Clostridium difficile infection (CDI) has been associated with recurrence of disease in up to 25% of infected persons. This study investigated the effects of vancomycin on the clinical outcomes, intestinal histopathology, and anaerobic community during and after treatment in a murine model of CDI. C57BL/6 ...
Goldstein Lawrence S B - - 2012
Human pluripotent stem cells provide enormous opportunities to treat disease using cell therapy. But human stem cells can also drive biomedical and cell biological discoveries in a human model system, which can be directly linked to understanding disease or developing new therapies. Finally, rigorous scientific studies of these cells can ...
Farias Luis Henrique S - - 2012
Background. Phosphatidylserine (PS) and surface carbohydrates (SC) are known as virulence factors that may contribute to the different clinical symptoms from self-healing cutaneous leishmaniasis lesions up to fatal visceral disease. Leishmania braziliensis causes localized cutaneous (LCL) and muco-cutaneous leishmaniasis (MCL).Methods. We analyzed PS exposure and SC expression of two primary Leishmania braziliensis ...
Kim B G - - 2012
An experiment was conducted to determine the true ileal digestibility (TID) and the true total tract digestibility (TTTD) of acid-hydrolyzed ether extract (AEE) in extracted corn oil, high-oil corn, distillers dried grains with solubles (DDGS), corn germ, and high protein distillers dried grains (HP DDG), and to compare these values ...
Strelcov Evgheni - - 2012
A new high-yield method of doping VO2 nanostructures with aluminum is proposed, which renders possible stabilization of the monoclinic M2 phase in free-standing nanoplatelets in ambient conditions and opens an opportunity for realization of a purely electronic Mott Transition Field-Effect Transistor without an accompanying structural transition. The synthesized free-standing M2-phase ...
Van De Logt Floor - - 2012
The inflammatory bowel diseases are incurable conditions that feature gut inflammation. Standard markers have inadequate sensitivity and specificity. S100A12 is a new faecal marker than has promise as a non-invasive indicator of gut inflammation. This article reviews recent studies focusing on S100A12 and highlights current and potential roles of this ...
Kamimoto Yoshihisa - - 2012
The phytohormone auxin is critical for plant growth and many developmental processes. Members of the P-glycoprotein (PGP/ABCB) subfamily of ABC transporters have been shown to function in the polar movement of auxin by transporting auxin over the plasma membrane in both monocots and dicots. Here, we characterize a new Arabidopsis ...
Ge Guang-Cun - - 2012
A new synthetic strategy to access polysubstituted furans regiospecifically has been developed using simple bicyclic alkenes and terminal ynones as starting materials with palladacycles as unique active catalysts. A rational mechanism has also been proposed. This reaction features mild reaction conditions, easily available starting materials and palladacycle catalysts, a wide ...
Sato Kumiko - - 2012
Photochemical reactions of Lu(3)N@I(h)-C(80) with disiliranes 1 and 2 produce several isomeric adducts. Spectroscopic analyses characterize the most stable isomers as 1,4(AA) adducts, which consist of paired twist conformers at rt. The electrochemical and theoretical studies reveal that the HOMO-LUMO energy gaps of the 1,4(AA) adducts are smaller than that ...
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