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Webster Craig C Department of Biochemistry and Immunology, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK. - - 2013
Vitamin D deficiency appears to be widespread and associated with ethnicity and economic status. Geography is the key to virtually all national statistics. It provides a structure for collecting, processing, storing and aggregating data. Linking geographic data to laboratory data allows analysis of the association of laboratory data with economic ...
Kirchhoff Helmut - - 2013
The photosynthetic performance of plants is crucially dependent on the mobility of the molecular complexes that catalyze the conversion of sunlight to metabolic energy equivalents in the thylakoid membrane network inside chloroplasts. The role of the extensive folding of thylakoid membranes leading to structural differentiation into stacked grana regions and ...
Lungu C - - 2012
BACKGROUND AND PURPOSE: Injectable botulinum neurotoxin (BoNT) is the principal effective treatment for blepharospasm (BSP). This trial explores the safety and efficacy of topical acetyl hexapeptide-8 (AH8), a competitive SNAP25 inhibitor, as a potential new therapy in BSP. METHODS: Double-blind, placebo-controlled, randomized trial of daily topical application of AH8 in ...
Casabon Israël - - 2012
The cholesterol catabolic pathway occurs in most mycolic acid-containing actinobacteria, such as Rhodococcus jostii RHA1, and is critical for Mycobacterium tuberculosis (Mtb) during infection. FadD3 is one of four predicted acyl-CoA synthetases potentially involved in cholesterol catabolism. A ΔfadD3 mutant of RHA1 grew on cholesterol to half the yield of ...
Hashikawa Andrew N - - 2012
BACKGROUND:The American Academy of Pediatrics (AAP) introduced revised return-to-care recommendations for mildly ill children in 2009 that were added to national standards in 2011. Child care directors' practices in a state without clear emphasis on return-to-care guidelines are unknown. We investigated director return-to-care practices just before the release of recently ...
Fiolic Zlatko - - 2012
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major global health care-associated pathogen. This study sought to examine the prevalence of MRSA in patients who were admitted to a vascular surgery ward during a 3-month period. Methods: MRSA screening was accomplished through the acquisition of nasal, throat and perineal swabs. These ...
Jaksch Peter - - 2012
Cystic fibrosis (CF) is an inherited condition that leads to respiratory failure and is the third most common indication for adult bilateral lung transplantation (LuTX). In contrast to other lung diseases, the immune system of CF patients is up-regulated and we therefore hypothesized that these patients would benefit from induction ...
Cook Richard J - - 2012
BACKGROUND: Several randomized trials of platelet (PLT) products have been conducted with different study designs, endpoints, and analyses. The purpose of this article is to discuss methodologic issues in the design and analysis of PLT transfusion trials evaluating pathogen reduction technology and make recommendations for the conduct of future trials. ...
Quintavalle Cristina - - 2012
BACKGROUND: The role of statins in the prevention of contrast induced acute kidney injury (CIAKI) is controversial. METHODS AND RESULTS: We investigated 1) the in vivo effects of atorvastatin on CIAKI. Patients with chronic kidney disease (CKD) enrolled into the NAPLES II trial were randomly assigned to a) Atorvastatin group ...
Bartel Gregor - - 2012
Protocols for recipient desensitization may allow for successful kidney transplantation across major immunological barriers. Desensitized recipients, however, still face a considerable risk of antibody-mediated rejection (AMR), which underscores the need for risk stratification tools to individually tailor treatment. Here, we investigated whether solid phase detection of complement-fixing donor-specific antibodies (DSA) ...
Carlson Linda E - - 2012
BACKGROUND: This randomized controlled trial examined the impact of an online routine screening for distress program on physical symptoms and common psychosocial and practical problems in lung cancer outpatients. METHOD: Patients were randomly assigned to either the minimal screening group (the Distress Thermometer plus usual care); full screening group (Distress ...
Smith Pete - - 2012
One of the greatest challenges we face in the twenty-first century is to sustainably feed nine to ten billion people by 2050 while at the same time reducing environmental impact (e.g. greenhouse gas (GHG) emissions, biodiversity loss, land use change and loss of ecosystem services). To this end, food security ...
Theil P K - - 2012
Two experiments were conducted with the aim of studying how dietary fat source, reproductive stage (Exp. 1), and diurnal variation (Exp. 2) affect plasma ketone bodies in sows. In Exp. 1, 40 second-parity sows were fed 1 of 5 lactation diets from 7 d pre-partum until 28 d postpartum with ...
Wu Dan D Laboratory of Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chiba 260-8717, - - 2013
Representative tumor suppressor p53 plays a critical role in the regulation of proper DNA damage response. In this study, we have found for the first time that Runt-related transcription factor 1 (RUNX1) contributes to p53-dependent DNA damage response. Upon adriamycin (ADR) exposure, p53 as well as RUNX1 were strongly induced ...
Janvier Annie - - 2012
There have been over twenty prospective, randomized trials of the use of probiotics to prevent necrotizing enterocolitis (NEC) in premature babies. A Cochrane meta-analysis of 16 of the studies by Khalid Al Faleh and colleagues, enrolling 2842 preterm infants, reported that "enteral probiotics supplementation significantly reduced the incidence of severe ...
Gresnigt Mark S - - 2012
IL-1 drives T-helper responses, particularly Th17, in host defense. Sharing the same co-receptor, the IL-1 family member IL-36 exhibits properties similar to those of IL-1. In the present study, we investigated the role of IL-36 in Aspergillus fumigatus-induced human T-helper cell responses. We observed that different morphological forms of A. ...
Qu Baihua - - 2012
Electrochemical supercapacitors have drawn much attention because of their high power and reasonably high energy densities. However, their performances still do not reach the demand of energy storage. In this paper β-cobalt sulfide nanoparticles were homogeneously distributed on a highly conductive graphene (CS-G) nanocomposite, which was confirmed by transmission electron ...
Lepski Silke - - 2012
Allergic reactions to food can significantly reduce the quality of life and even result in life-threatening complications. In addition, the prevalence of food allergy has increased in the last decades in industrialized countries and the mechanisms underlying (increased) sensitization are still not fully understood. It is believed that the development ...
Nabi-Burza Emara E Center for Child and Adolescent Health Research and Policy, Massachusetts General Hospital for Children, Boston, MA 02114, - - 2012
To determine prevalence and factors associated with strictly enforced smoke-free car policies among smoking parents. As part of a cluster, randomized controlled trial addressing parental smoking, exit interviews were conducted with parents whose children were seen in 10 control pediatric practices. Parents who smoked were asked about smoking behaviors in ...
Van der Linden Trudy - - 2012
The objective of this paper is to compare concentrations of alcohol, illicit, and medicinal drugs in seriously injured drivers and drivers selected randomly at the roadside. Blood samples were analyzed for alcohol, 17 medicinal drugs and 8 illicit psychoactive substances and/or their metabolites by ultra performance liquid chromatography-tandem mass spectrometry ...
Fraysse Guillaume - - 2012
We report unprecedented dramatic changes in the 647.1 nm Raman signal of PbZr(0.6)Ti(0.4)O(3) occurring in the same pressure ranges as the critical pressures of the antiferrodistortive and ferroelectric-paraelectric phase transitions. This huge decrease in intensity of both the Raman modes and the background, observed for both pressure transmitting media used ...
Xu Chao - - 2012
Oat protein was purified from oat meal and its effects on swimming performance and related biochemical parameters were investigated. Thirty male Kun-ming mice were divided into the normal control, the oat meal and the oat protein group (n = 10). They were fed with a laboratory food for 30 days, ...
Sakata Hidekatsu - - 2012
BACKGROUND: To reduce the risk of human parvovirus B19 (B19V) transmission through contaminated blood for transfusion and plasma-derived products, the Japanese Red Cross (JRC) Blood Centers introduced B19V antigen screening by chemiluminescent enzyme immunoassay (CLEIA-B19V) in 2008. STUDY DESIGN AND METHODS: Donor samples that were positive by CLEIA-B19V screening were ...
Chuquimia Olga D - - 2013
The respiratory epithelium is a physical and functional barrier actively involved in the clearance of environmental agents. The alveolar compartment is lined with membranous pneumocytes, known as type I alveolar epithelial cells (AEC I), and granular pneumocytes, type II alveolar epithelial cells (AEC II). AEC II are responsible for epithelial ...
Lee Jungmin - - 2012
The ability to straightforwardly deliver engineered nanoparticles into the cell cytosol with high viability will vastly expand the range of biological applications. Nanoparticles could potentially be used as delivery vehicles or as fluorescent sensors to probe the cell. In particular, quantum dots (QDs) may be used to illuminate cytosolic proteins ...
Lavelle Bridget - - 2012
This article bridges the literatures on the economic consequences of divorce for women with that on marital transitions and health by focusing on women's health insurance. Using a monthly calendar of marital status and health insurance coverage from 1,442 women in the Survey of Income and Program Participation, we examine ...
Mollan Katie K Harvard School of Public Health, Center for Biostatistics in AIDS Research, FXB Bldg, 651 Huntington Ave, Boston, MA 02115-6017, USA. - - 2012
Although specific human immunodeficiency virus type 1 (HIV-1) drug resistance mutations are well studied, little is known about cumulative amino acid changes, or how regimen and participant characteristics influence these changes. In the AIDS Clinical Trials Group randomized study A5202 of treatment-naive HIV-infected participants, cumulative HIV-1 amino acid changes from ...
Liotta Janice L - - 2012
Abstract An examination was made of Giemsa-stained microfilariae in thin blood films from dogs naturally or experimentally infected with Dirofilaria immitis or Dirofilaria repens. The blood was from 9 dogs infected with D. immitis and 9 dogs infected with D. repens. Measurements (total length, length of cephalic space, anterior end ...
Brembilla-Perrot Béatrice - - 2012
AIMS: Orthodromic atrioventricular reentrant tachycardia (ORT) is the most common arrhythmia at electrophysiological study (EPS) in patients with pre-excitation. The purpose of the study was to determine the clinical significance and the electrophysiological characteristics of patients with inducible antidromic tachycardia (ADT).METHODS AND RESULTS: Electrophysiological study was performed in 807 patients ...
Manley K - - 2012
Endometrial cancer is the fourth most common female cancer in the UK and the most common gynaecological cancer. Quality of life and symptom control needs to be considered in women who enter a surgically induced menopause. Hormone replacement in this population has been controversial to date. The current evidence regarding ...
Shao Wenli - - 2012
The luminescence, excited-state absorption and singlet oxygen generation measurements were performed on three kinds of halogenated corroles: mono-hydroxyl halogenated corroles (Corrole-F, Corrole-Cl, Corrole-I), peripherally fluorine-substituted corroles (F0, F5, F10, F15) and gallium complexes (F10-Ga, F15-Ga). The fluorescence intensities progressively decrease whereas the triplet quantum yields, oxygen quenching rates and singlet ...
Paredes Xavier - - 2012
Using molecular dynamics simulations we have studied the structure of alkylsulfate based ionic liquids: 1-ethyl-3-methylimidazolium n-alkylsulfate [C2C1im][CnSO4] (n = 2, 4, 6 and 8). The structure of the different ionic liquids have been interpreted taking into account radial and spatial distribution functions, and structure factors, that allowed us to characterize ...
Chung Hye Gyo - - 2012
The inhibitory effect of propofol on platelet aggregation remains unclear, and studies on the subject disagree. Furthermore, although propofol infusions are widely used for general anesthesia and as sedatives for patients in intensive care units, little information is available on its concentration- and time-related effects on platelet aggregation. Here, the ...
Thabet Michel M Centre for Vision Research, York University, - - 2013
Flickering light has been shown to sensitize the migraine visual system at high stimulus contrast while elevating thresholds at low contrast. The present study employs a dichoptic psychophysical paradigm to ask whether the abnormal adaptation to flicker in migraine occurs before or after the binocular combination of inputs from the ...
Hamade Yaman - - 2012
By using the CASSCF/MRCI methods, the theoretical electronic structure of the LuCl molecule has been investigated. These methods have been performed for 20 singlet and triplet electronic states in the representation 2s+1Λ(+/-) without the spin-orbit effects. Calculated potential energy curves (PECs) are also displayed. Spectroscopic constants including the harmonic vibrational ...
Matarazzo Bridget B - - 2012
The lack of a standardized nomenclature for suicide-related thoughts and behaviors prompted the Centers for Disease Control and Prevention, with the Veterans Integrated Service Network 19 Mental Illness Research Education and Clinical Center, to create the Self-Directed Violence Classification System (SDVCS). SDVCS has been adopted by the Department of Veterans ...
Gianella Sara S University of California-San Diego, La Jolla 92093-0679, USA. - - 2013
To investigate the role of genital shedding of herpesviruses in human immunodeficiency virus type 1 (HIV) transmission, we compared 20 HIV-infected men who did and 26 who did not transmit HIV to their sex partners. As described previously, HIV transmission was associated with the potential source partner having higher levels ...
Felten A - - 2012
We have recently identified apoptosis-antagonizing transcription factor (AATF), tumor-susceptibility gene 101 (TSG101) and zipper-interacting protein kinase (ZIPK) as novel coactivators of the androgen receptor (AR). The mechanisms of coactivation remained obscure, however. Here we investigated the interplay and interdependence between these coactivators and the AR using the endogenous prostate specific ...
Avila-Stagno J - - 2012
Two experiments were conducted to evaluate the effects of increasing concentrations of glycerol in concentrate diets on total tract digestibility, methane (CH4) emissions, growth, fatty acid profiles and carcass traits of lambs. In both experiments, the control diet contained 57% barley grain, 14.5% wheat dried distillers grain with solubles (WDDGS), ...
Cordente Antonio G - - 2012
Acetic acid, a byproduct formed during yeast alcoholic fermentation, is the main component of volatile acidity (VA). When present in high concentrations in wine, acetic acid imparts an undesirable 'vinegary' character that results in a significant reduction in quality and sales. Previously, it has been shown that saké yeast strains ...
Fanourgiakis John J Department of Cardiology, Heraklion University Hospital, PO Box 1352 Stavrakia, Heraklion, Crete 711 10, Greece. - - 2013
The aim of the present study is to estimate the procedure (implantation) cost, the total hospitalization cost and annual follow-up cost, in patients subjected to pacemaker (PM) and implantable cardioverter-defibrillator (ICD) implantation. A single-center, prospective, cost-of-illness study was conducted between August 2008 and July 2009. In total, 464 consecutive patients ...
Zhao Jinping - - 2013
The multifunctional movement protein (MP) of Tomato mosaic tobamovirus (ToMV) is involved in viral cell-to-cell movement, symptom development, and resistance gene recognition. However, it remains to be elucidated how ToMV MP plays such diverse roles in plants. Here, we show that ToMV MP interacts with the Rubisco small subunit (RbCS) ...
Bastami Salumeh - - 2012
Most patients with advanced cancer experience severe pain and are often treated with opiates. Cancer patients are especially susceptible to opportunistic infections due to treatment with immunosuppressive and cytostatic drugs. Since opiates have been demonstrated to have immunomodulatory effects, it is of clinical importance to evaluate potential differences between commonly ...
Chen Kuan-Chung - - 2012
Insulin-degrading enzyme (IDE) gene is one of the type 2 diabetes mellitus susceptibility genes specific to the Han Chinese population. IDE, a zinc-metalloendopeptidase, is a potential target for controlling insulin degradation. Potential lead compounds for IDE inhibition were identified from traditional Chinese medicine (TCM) through virtual screening and evaluation of ...
Atladóttir Hjördis Ósk - - 2012
OBJECTIVES:Results of animal studies suggest that maternal immune activation during pregnancy causes deficiencies in fetal neurodevelopment. Infectious disease is the most common path to maternal immune activation during pregnancy. The goal of this study was to determine the occurrence of common infections, febrile episodes, and use of antibiotics reported by ...
Chang Stanley - - 2012
A silver(I)-promoted intramolecular hemiacetal alkylation has been developed that converts readily available keto-chlorodiols into functionalized spiroacetals containing 5,5-, 5,6-, and 5,7-membered ring systems. The efficiency of this process is demonstrated in a concise total synthesis of the fungal metabolites cephalosporolides E and F.
Haydin Sertac - - 2012
Near-infrared spectroscopy (NIRS) is a noninvasive modality to monitor regional brain oxygenation (rSO(2) ). In this study, we aimed to investigate the correlation between cerebral rSO(2) and lactate, pump flow, hematocrit, pCO(2) , and mean blood pressure (MBP) during cardiopulmonary bypass (CPB). Between March and September 2011, 50 pediatric patients ...
Thorpe-Beeston Jg - - 2012
OBJECTIVE: To describe the maternal and fetal outcomes of pregnancies in women with cystic fibrosis. DESIGN: Retrospective study. SETTING: Single obstetric hospital and adult cystic fibrosis centre. METHODS: Retrospective case-note review of pregnant women with cystic fibrosis referred for antenatal care and delivery. MAIN OUTCOME MEASURES: Maternal and fetal outcomes, ...
Kennelly R P - - 2013
Rectal cancer outcomes following abdominoperineal excision (APE) have been inferior to those for anterior resection, including more positive circumferential resection margins (CRMs). An erroneously conservative interpretation of APE (rather than a radical resection termed 'extralevator') has been proposed as the cause. In this multicentre study, factors contributing to CRM positivity ...
Monte Milena M - - 2013
Lower vertebrates have been found to possess genes that have similar homology to both interleukin (IL)-17A and IL-17F, which have been termed IL-17A/F. In fish species, several of these genes can be present, but, to date, very little is known about their functional activity. This article describes the discovery and ...
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