Search Results
Results 551 - 600 of 2469
< 7 8 9 10 11 12 13 14 15 16 17 >
Nasu Mamiko - - 2012
Most pharmaceutical drug substances and excipients in formulations exist in a crystalline or amorphous form, and an understanding of their state during manufacture and storage is critically important, particularly in formulated products. Carbon 13 solid-state nuclear magnetic resonance (NMR) spectroscopy is useful for studying the chemical and physical state of ...
Park Sanghwa - - 2013
Two aerobic, Gram-stain-negative, pale-red-pigmented and rod-shaped bacterial strains, designated SAORIC-26 and SAORIC-28(T), were isolated from seawater (3000 m depth) from the Pacific Ocean. Phylogenetic analysis based on their 16S rRNA gene sequences revealed that the novel isolates could be affiliated with the family Rhodothermaceae of the class Cytophagia. Strains SAORIC-26 ...
Roldán-Alzate Alejandro A Department of Radiology, University of Wisconsin, Madison, WI 53705, USA. - - 2013
To implement and validate in vivo radial 4D flow MRI for quantification of blood flow in the hepatic arterial, portal venous, and splanchnic vasculature of healthy volunteers and patients with portal hypertension. Seventeen patients with portal hypertension and seven subjects with no liver disease were included in this Health Insurance ...
Wang Zhe-Ming - - 2012
Aggravating aggregation: An N-terminal domain that is in close proximity to the polyQ domain in the huntingtin protein, htt105-138 is shown to be highly aggregation prone. Potential cross-talk between this domain and the polyQ region may play a central role in regulating the aggregation and toxicity of Htt-N-terminal fragments.
Cauchy F - - 2012
BACKGROUND: The incidence of metabolic syndrome-associated hepatocellular carcinoma (MS-HCC) is increasing. However, the results following liver resection in this context have not been described in detail. METHODS: Data for all patients with metabolic syndrome as a unique risk factor for HCC who underwent liver resection between 2000 and 2011 were ...
Knudsen C S - - 2012
OBJECTIVES: To report on a series of dogs and cats with long bone fractures that occurred as a direct consequence of linear external skeletal fixation (ESF) application. METHODS: Retrospective study. Data from the medical records and radiographs of canine (n = 4) and feline (n = 7) cases were collected from three referral and ...
Di Minno M N D - - 2012
Peripheral arterial disease (PAD) predicts cardiovascular and cerebrovascular ischemic events. PAD treatment is aimed at reducing clinical symptoms, local tissue loss and at preventing complications. Aims:To evaluated the effect of peridural analgesia on peripheral perfusion and pain control.In 280 diabetic subjects with severe limb ischemia (65.7% males and 34.3% females, ...
Hites Maya - - 2012
Severe sepsis and septic shock can alter the pharmacokinetics of broad-spectrum β-lactams (meropenem, ceftazidime/cefepime, and piperacillin-tazobactam), resulting in inappropriate serum concentrations. Obesity may further modify the pharmacokinetics of these agents. We reviewed our data on critically ill obese patients, (body mass index ≥30 kg/m(2)), treated with a broad-spectrum β-lactam in ...
Ostertag Maya - - 2012
Membrane trafficking is vital to plant development and adaptation to the environment. It is suggested that post-Golgi vesicles and multivesicular bodies are essential for plant defence against directly penetrating fungal parasites at the cell wall. However, the actual plant proteins involved in membrane transport for defence are largely unidentified. We ...
Nakano Shu-Ichi - - 2012
Incorporation of modified nucleotides into nucleic acid strands often produces conformational constraints and steric hindrances that may change the property of base pairing. In this study, we investigated a 2'-deoxycytidine derivative that tethers a phenyl moiety to the exocyclic amino group of cytosine linked through a ureido group. This derivative ...
Castillo-Lopez E - - 2012
The objectives of this trial were to determine the rumen undegradable protein (RUP) of dried distillers grains with solubles (DDGS), to compare the estimates of duodenal bacterial crude protein (BCP) flow using diaminopumelic acid (DAPA) or DNA as bacterial markers, and to estimate duodenal protozoal crude protein (PCP) and yeast ...
Herrel Lindsey - - 2013
Up to 6% of men who have undergone vasectomy will ultimately elect for reversal in the form of vasovasostomy or vasoepididymostomy for various reasons. Vasovasostomy performed to regain fertility is a technique that has undergone numerous advances during the last century, including the use of microsurgical equipment and principles to ...
Muili Kamaldeen A KA Department of Pediatrics, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, - - 2013
Biliary pancreatitis is the leading cause of acute pancreatitis in both children and adults. A proposed mechanism is the reflux of bile into the pancreatic duct. Bile acid exposure causes pancreatic acinar cell injury through a sustained rise in cytosolic Ca(2+). Thus, it would be clinically relevant to know the ...
Houlihan D D DD Liver Unit, Queen Elizabeth Hospital, Birmingham, UK. - - 2013
Liver transplantation is potentially a life-saving therapeutic intervention for patients with portopulmonary hypertension and hepatopulmonary syndrome. However, due to limited data, listing criteria for patients with these conditions have not been clearly established. Indeed, this has led some to speculate that transplantation may not be appropriate in cases of moderate-to-severe ...
Hatzikiriakos Savvas G - - 2012
The rheological properties and microstructure of nanocrystalline cellulose (NCC) aqueous suspensions have been investigated at different concentrations. The suspension is isotropic up to 3 wt.%, and phase separates to liquid crystalline and isotropic domains at higher concentrations where the samples exhibit a fingerprint texture and the viscosity profile shows a ...
Yap Desmond Y H - - 2012
Objective. We investigated the long-term outcome of patients with proliferative LN treated with CSs and MMF.Methods. This was a single-centre retrospective study on patients with biopsy-proven class III/IV ± V LN treated with prednisolone and MMF continuously as both early and maintenance immunosuppression.Results. Sixty-five patients were included, and followed for ...
Eng Jimmy K - - 2012
Proteomics research routinely involves identifying peptides and proteins via tandem mass spectrometry sequence database search. Thus the database search engine is an integral tool in many proteomics research groups. Here, we introduce the Comet search engine to the existing landscape of commercial and open source database search tools. Comet is ...
Wang Baojiang - - 2012
We report the cellular properties of a luminescent cyclometalated iridium(III) complex, [Ir(pq)(2) (phen-ITC)](PF(6) ) (Ir-ITC; Hpq=2-phenylquinoline, phen-ITC=5-isothiocyanate-1,10-phenanthroline), that efficiently and specifically labels mitochondria in living mammalian cells. Ir-ITC can be covalently conjugated to its protein targets, and its luminescence survived cell lysis, protein extraction, and gel electrophoresis under denaturing conditions. ...
Seifarth C - - 2012
The efficacy of metformin for the treatment of obesity has been evaluated in few clinical trials with inconclusive results. Moreover, the effectiveness in a real-life outpatient setting has not been tested until today. In this study we aimed to examine the effectiveness of metformin as a weight reducing drug in ...
Choi Hyun Gyu - - 2012
The stem and root barks of Ulmus davidiana var. japonica (Ulmaceae) have been used to treat inflammatory diseases including mastitis, rhinitis, sinusitis, and enteritis. In an ongoing study focused on the discovery of natural anti-inflammatory compounds from natural products, a methanol extract of the stem and root barks of U. ...
Yang Heejung - - 2012
Two ginsenoside derivatives (9-10) along with ten known ginsenosides (1-8 and 11-12) were isolated from BST204 which is crude ginseng extract fermented by enzyme and acid hydrolysis. The two ginsenosides were determined as 12β, 20(S), 25-trihydroxy-dammara-3-O-β-D-glucopyranoside (9) and 12β, 20(R), 25-trihydroxy-dammara-3-O-β-D-glucopyranoside (10). Compounds 1-12 were categorized into steroisomeric pairs differentiated ...
Sun Nuo - - 2013
Mitochondrial dysfunction in pathogenic fungi or model yeast causes altered susceptibilities to antifungal drugs. Here we have characterized the role of mitochondrial complex I (CI) of Candida albicans in antifungal susceptibility. Inhibitors of CI to CV, except for CII, increased the susceptibility of both patient and lab isolates, even those ...
Henry F - - 2012
The aim of the present study was to evaluate the effects of metal contamination on the biological responses of 0-group juvenile European flounder and to assess and compare the quality of four estuarine habitats located in the Eastern English Channel. Fish otolith growth and condition indices (RNA : DNA ratio, Fulton's K ...
Yáñez J L - - 2012
Traditional supplemental dietary phytase loses activity during steam pelleting. The thermal tolerance and bio-efficacy of a phytase product with a thermo-protective coating (C-phytase) was compared in mash and pelleted diets to a traditional, uncoated phytase (U-phytase) added to a negative control (NC) diet, formulated with reduced dietary Ca and P, ...
Akmal S S Department of Neurosurgery, Queen Elizabeth Hospital, Birmingham, UK. - - 2013
This technical note describes the application of neuroendoscopy for decompressing and obtaining tissue samples from cystic intracerebral tumours. The method provides for visualisation of the solid tumour component prior to biopsy and retains the advantages of being a burr hole procedure.
Van de Velde Sarah - - 2012
A recurrent finding in international literature is a greater prevalence of depression in women than in men. While explanations for this gender gap have been studied extensively at the individual level, few researchers have studied macro-level determinants of depression in men and women. In the current study we aim to ...
Radhakrishnan Anant - - 2012
This retrospective study describes a technique and evaluates outcome associated with laparoscopic splenic biopsy in dogs and cats. Medical records of dogs (n = 10) and cats (n = 5) that had a laparoscopic splenic biopsy performed as part of their diagnostic evaluation for systemic disease were evaluated. Splenic biopsies ...
Ribeiro Francinne Machado - - 2012
Objective. Data about the survival rate of lupus patients on dialysis is controversial. The objective of this controlled prospective study was to report the survival of SLE patients undergoing dialysis and to analyse factors associated with mortality.Methods. Twenty dialysis centres were visited between May 2003 and February 2004. Disease activity ...
Zonfrillo Mark R - - 2012
OBJECTIVE:To determine the self-reported practices and attitudes surrounding concussion diagnosis and management in a single, large pediatric care network.METHODS:A cross-sectional survey was distributed to pediatric primary care and emergency medicine providers in a single, large pediatric care network. For all survey participants, practices and attitudes about concussion diagnosis and treatment ...
Ma Song-Tao - - 2012
Diabetic nephropathy (DN) is the major life-threatening complication of diabetes. Abnormal permeability of glomerular basement membrane plays an important role in DN pathogenesis. This study was performed to assess the effect of arctiin, the lignan constituent from Arctium lappa L., on metabolic profile and aggravation of renal lesions in a ...
Pai Manjunath P - - 2013
Obese patients may be at a greater risk for acute kidney injury (AKI) with the use of certain antimicrobial agents that are dosed by weight. Current preclinical models of AKI utilize the male rat within a narrow weight range that limits extrapolation of the generated results. We evaluated the pharmacokinetics ...
Toh Sengwee S Department of Population Medicine, Harvard Medical School, Boston, MA 02215, USA. - - 2012
Although certain drugs that target the renin- angiotensin-aldosterone system are linked to an increased risk for angioedema, data on their absolute and comparative risks are limited. We assessed the risk for angioedema associated with the use of angiotensin converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and the direct renin ...
Sakamoto Tomoaki - - 2012
The phytohormones auxin and brassinosteroid are both essential regulators of physiological and developmental processes, and it has been suggested that they act interdependently and synergistically. In rice (Oryza sativa), auxin co-application improves the brassinosteroid response in the rice lamina inclination bioassay. Here, we showed that auxin stimulates brassinosteroid perception by ...
Bohrer B M - - 2012
The objective was to summarize previous literature, using a meta-analysis approach, on the effects of ractopamine hydrochloride (RAC) when fed at doses of 5 to 10 mg/kg for up to 35 days prior to harvest on carcass cutability and belly quality of finishing pigs. The meta-analysis provided an opportunity to ...
Xiong Yun - - 2012
The novel chlorogermyliumylidene complex [ClGe:](+) ( = 1,8-bis(tri-n-butylphosphanzenyl)naphthalene) with a 'naked' Cl(-) as a counter anion was synthesized through reaction of with Cl(2)Ge: and fully characterized. Its reaction with elemental sulfur afforded the first germathionium [ClGe[double bond, length as m-dash]S](+) cation containing species. The latter has also been fully characterized, ...
Wang Yufei - - 2012
The solution-based manufacture of chemically converted graphene (CCG) provides a cost-effective and facile approach to construct graphene-based materials. However, uncontrollable wrinkles and aggregates are usually seen when transferring graphene sheets from solution to solid-state, significantly altering their optical, electrical and electrochemical properties. A number of strategies have been devoted to ...
Sun Lin - - 2012
Ketamine, a non-competitive N-methyl-D-aspartic acid receptor antagonist, has emerged as an increasingly popular drug among young drug abusers worldwide. Available evidence suggests that ketamine produces acute impairments of working, episodic and semantic memory along with psychotogenic and dissociative effects when a single dose is given to healthy volunteers. However, understanding ...
Harrison Sandy P - - 2012
Approximately 1-2% of net primary production by land plants is re-emitted to the atmosphere as isoprene and monoterpenes. These emissions play major roles in atmospheric chemistry and air pollution-climate interactions. Phenomenological models have been developed to predict their emission rates, but limited understanding of the function and regulation of these ...
Navarro-Compán Victoria - - 2012
Objective. To investigate the relationship between oxidative stress and smoking and development of RA.Methods. A case-control study was conducted in treatment-naïve early-onset RA patients and healthy controls, matched by age, gender and current smoking habit. Plasma lipid hydroperoxides (LOOH), carbonyl protein (CP) and malonyldialdehyde (MDA) levels were measured to estimate ...
McKenzie Blair M - - 2012
To penetrate soil, a root requires pressure both to expand the cavity it is to occupy, σ(n) and to overcome root-soil friction, σ(f) . Difficulties in estimating these two pressures independently has limited our ability to estimate the coefficient of soil-root friction, µ(sr) . We used a rotated penetrometer probe, ...
McKeown Joseph T - - 2012
Using pump-probe electron microscopy techniques, the dewetting of thin nickel films exposed to a pulsed nanosecond laser was monitored at tens of nanometers spatially and nanosecond timescales to provide insight into the liquid-phase assembly dynamics. Thickness-dependent and correlated time and length scales indicate that a spinodal instability drives the assembly ...
Koyano Kosuke - - 2012
BACKGROUND: Anemia of prematurity commonly occurs in infants with very low birth weight; blood transfusion is an important treatment. However, there is no clear evidence to support the criteria currently widely used, based on blood hemoglobin (bHb) and hematocrit indices. Previous studies showed that overtransfusion or a low threshold for ...
Singha Roy Atanu - - 2012
Green tea is rich in several polyphenols, such as (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC), and (-)-epigallocatechin-3-gallate (EGCG). The biological importance of these polyphenols led us to study the major polyphenol EGCG with human serum albumin (HSA) in an earlier study. In this report, we have compared the binding of ECG, EGC, ...
Noda Daisuke - - 2012
Treatment of (η(1)-mesityl)(2)Fe(κ(2)-TMEDA) () with an α,β-unsaturated carbonyl compound results in 1,4-addition of the mesityl group to give an iron enolate quantitatively. The Z-configuration of the enolate suggested the six-centered mechanism for the conjugate addition.
Chen Y C - - 2012
The aims of our meta-analysis were (i) to quantify the predictability of childhood overweight and obesity on the risk of incident asthma; and (ii) to evaluate the gender difference on this relationship. The selection criteria included prospective cohort paediatric studies which use age- and sex-specific body mass index (BMI) as ...
Stankov Metodi V - - 2013
Lipoatrophy in HIV patients can result from prolonged exposure to thymidine analogues. Mitochondrial toxicity leading to dysregulated adipogenesis and increased cell death has been proposed as a leading factor in the etiology of peripheral fat loss. We hypothesized that thymidine analogues interfere with autophagy, a lysosomal degradation pathway, which is ...
Reymond Nicolas N Randall Division of Cell and Molecular Biophysics, King's College London, London SE1 1UL, England, - - 2012
Cancer cells interact with endothelial cells during the process of metastatic spreading. Here, we use a small interfering RNA screen targeting Rho GTPases in cancer cells to identify Cdc42 as a critical regulator of cancer cell-endothelial cell interactions and transendothelial migration. We find that Cdc42 regulates β1 integrin expression at ...
Roque Edelín - - 2012
The B-class of MADS-box genes has been studied in a wide range of plant species, but it has remained largely uncharacterized in legumes. Here we investigate the evolutionary fate of the duplicated AP3-like genes of a legume species. To gain insight into the extent to which B-class MADS-box gene functions ...
Zhang Lin - - 2012
Millions of platelets are produced each hour by bone marrow (BM) megakaryocytes (MKs). MKs extend transendothelial proplatelet (PP) extensions into BM sinusoids and shed new platelets into the blood. The mechanisms that control platelet generation remain incompletely understood. Using conditional mutants and intravital multiphoton microscopy, we show here that the ...
Sun Tao - - 2012
Interfaces usually impede heat transfer in heterogeneous structures. Recent experiments show that van der Waals (vdW) interactions can significantly enhance thermal conductivity parallel to the interface of a bundle of nanoribbons compared to a single layer of freestanding nanoribbon. In this paper, by simulating heat transfer in nanostructures based on ...
< 7 8 9 10 11 12 13 14 15 16 17 >