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Results 501 - 550 of 2469
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Edge J A - - 2012
AIM: Hospital inpatient care for children with diabetes is frequently mentioned by parents as unsatisfactory. The aim of this study was to examine the reasons for inpatient admission of children with diabetes and to understand patient and carer experience in order to improve services. METHODS: Questionnaires were given to medical ...
Haberhauer Gebhard - - 2012
Significance: This review relates to artificial redox-driven molecular devices. The advantages of using very simple chemical building blocks for the bottom-up design of nano-leveled functional motors and the importance of the unidirectionality of a switching process for the development of redox-driven molecular motors are discussed. Furthermore, the crucial difference between ...
Yoon Hyun Kyung - - 2012
Objective. Aberrant splicing is one of the most significant components generating functional diversity in many pathological conditions. The objective of this study was to analyse the mutations or aberrant splicing of A20 transcript, the region encompassing the ovarian tumour (OTU) domain [which is functionally important as an inhibitor of nuclear ...
Yasuda Norihisa - - 2012
In this report, we studied whether plasma concentration of nicorandil is maintained effectively and safely in dialysis-dependent patients with stage 5 chronic kidney disease (CKD5D) undergoing continuous renal replacement therapy (CRRT). Participants consisted of 10 patients undergoing CRRT after cardiac surgery. CRRT was performed with an effluent flow rate of ...
Usher K - - 2012
ACCESSIBLE SUMMARY: Weight gain is a known, predictable side-effect of second-generation antipsychotic drugs. Study participants reported struggling to manage the insatiable appetite and weight gained associated with the drugs. Cessation of prescribed medication was considered by most as a way of managing the weight gain associated with the drugs. ABSTRACT: ...
Golden Neville H - - 2012
OBJECTIVE:To test the hypothesis that the weight-for-stature (WFS) and BMI methods are not equivalent in determining expected body weight (EBW) in adolescents with eating disorders and to determine the sensitivity, specificity, and positive predictive value of each method to detect those <75% EBW. We hypothesized that differences in EBW would ...
Lomoth Reiner - - 2012
Significance: Control over reversible changes to molecular structure forms the basis for artificial molecular machines that could eventually lead to the development of molecule based nanotechnology. Recent Advances: Particular applications in information storage and processing could emerge where the structural rearrangements give rise to bistability and molecular hysteresis effects. Critical ...
He Xi - - 2012
Ischemic preconditioning (IPC) strongly protects against ischemia/reperfusion (I/R) injury; however, the molecular mechanism involved in delayed preconditioning-induced endothelial protection in peripheral arteries is unknown. Therefore, we examined using functional, morphologic and molecular biologic studies whether delayed IPC decreases formation of reactive oxygen species and upregulates endothelial nitric oxide synthase (eNOS) ...
Gheidi Mahin - - 2012
Iron-oxophlorin is an intermediate in heme degradation, and the metal oxidation number can alter spin, electron distribution, and the reactivity of the metal and the oxophlorin ring. The role of electron transfer in the structure and reactivity of [(Py)(2)Fe(III)(PO)] (PO is the oxophlorin trianion) in different redox states has been ...
Mooney Thomas J - - 2012
Several fuel spills have occurred on subantarctic Macquarie Island (54°30' S 158°57' E) associated with storing fuel and generating power for the Island's research station. The Australian Antarctic Division began full-scale, on-site remediation of these sites in 2009. To develop appropriate target concentrations for remediation, acute and chronic tests were ...
Gourbeyre Pascal - - 2012
Prebiotics constitute emerging tools to alleviate immune pathologies. This study aimed to evaluate the effect of prebiotic exposure during perinatal and post-weaning periods on immune and gut regulations. Mice were fed either a galactooligosaccharides/inulin prebiotic mix-enriched diet or a control diet during the perinatal and/or post-weaning periods. Biomarkers related to ...
Mc Donnell Conor - - 2012
INTRODUCTION: Clinical outcomes in pediatric anesthesia have improved significantly over the last 20-30 years but unexpected laryngospasm that is difficult to treat can still result in patient morbidity, increased postoperative medical management and unnecessary hospital admission. The incidence of laryngospasm in pediatric anesthesia is difficult to determine with incidences from 0.9% ...
Blake John T - - 2012
BACKGROUND: Since the 1970s red blood cells (RBCs) have had a rated shelf life of 42 days. Recently, studies have suggested poorer patient outcomes when older blood is transfused. However, shortening the shelf life of RBCs may increase costs and lead to greater instances of outdates and shortages. STUDY DESIGN ...
Distler Alfiya - - 2012
OBJECTIVES: Canonical Wnt signalling has recently emerged as a key mediator of fibroblast activation and tissue fibrosis in systemic sclerosis. Here, we investigated tankyrases as novel molecular targets for inhibition of canonical Wnt signalling in fibrotic diseases. METHODS: The antifibrotic effects of the tankyrase inhibitor XAV-939 or of siRNA-mediated knockdown ...
Kileh-Wais M - - 2012
The mule duck, an interspecific hybrid obtained by crossing common duck (Anas Platyrhynchos) females with Muscovy (Cairina moschata) drakes, is widely used for fatty liver production. The purpose of the present study was to detect and map single and pleiotropic QTL that segregate in the common duck species, and influence ...
Balbus John M - - 2012
Global climate change (GCC) is likely to alter the degree of human exposure to pollutants and the response of human populations to these exposures, meaning that risks of pollutants could change in the future. The present study, therefore, explores how GCC might affect the different steps in the pathway from ...
Chambers Gregory - - 2012
This report discusses the diagnosis and treatment of afibrinogenemia in a Chihuahua. Prolongations of prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin clotting time (TCT) together with fibrinogen assay results of either no or trace amounts of fibrinogen support a diagnosis of afibrinogenemia. Differential diagnoses include common coagulopathies, ...
Bruschi Giovanni B - - 2012
Abstract Purpose: Since the presence of keratinized gingiva is so important for peri-implant outcome, the aim of this study is to describe a partial thickness flap design to increase the amount of keratinized peri-implant tissue as well as its thickness.Materials and Methods: A total of 131 implants were placed: 103 ...
Corsi Daniel J - - 2012
Demographic and Health Surveys (DHS) are comparable nationally representative household surveys that have been conducted in more than 85 countries worldwide since 1984. The DHS were initially designed to expand on demographic, fertility and family planning data collected in the World Fertility Surveys and Contraceptive Prevalence Surveys, and continue to ...
Vaneechoutte Mario - - 2012
Three gram-negative strains , NF 1078T, NF 1598 and NF 1715 were isolated clinically (2) and environmentally (1), respectively. Sequence analysis of the 16S rRNA genes revealed a 16S rRNA gene sequence similarity of 100% and the highest 16S rRNA gene sequence similarity to Acidovorax avenae subsp. avenae (98.16%). The ...
von Segesser Ludwig K - - 2012
There is no doubt that the European Association for Cardio-Thoracic Surgery is a success story. In 2011, we celebrated the 25th anniversary of this professional organization. In 2012, we will celebrate the 25th anniversary of the European Journal of Cardio-Thoracic Surgery. In addition, two other journals have been initiated, Interactive ...
Scragg Jonathan James - - 2012
Experimental proof is presented for a hitherto undetected solid-state reaction between the solar cell material Cu(2)ZnSn(S,Se)(4) (CZTS(e)) and the standard metallic back contact, molybdenum (Mo). Annealing experiments combined with Raman and TEM studies show that this aggressive reaction causes formation of MoS(2) and secondary phases at the CZTS|Mo interface during ...
Hunn Martin K - - 2012
PURPOSE: The prognosis for patients with glioblastoma multiforme (GBM) remains extremely poor despite recent treatment advances. There is an urgent need to develop novel therapies for this disease.EXPERIMENTAL DESIGN: We used the implantable GL261 murine glioma model to investigate the therapeutic potential of a vaccine consisting of intravenous injection of ...
Miles Mathew C - - 2012
Chronic obstructive pulmonary disease (COPD) is a serious global health burden. Comprehensive management of COPD includes both pharmacologic and non-pharmacologic interventions aimed at improving disease-related functional capacity, health-related quality of life, and survival. The primary medications used for treatment of COPD are inhaled bronchodilator drugs which are delivered directly to ...
Mahmud Salaheddin M - - 2012
Please cite this paper as: Mahmud et al. (2012) Outbreaks of influenza-like illness in long-term care facilities in Winnipeg, Canada. Influenza and Other Respiratory Viruses 10.1111/irv.12052 Background  Outbreaks of influenza-like illness (ILI) are common in long-term care facilities (LTCFs) and result in significant morbidity and mortality among residents. Objectives  We describe ...
Chow Wong-Ho WH Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. - - 2013
Patients with renal cell carcinoma (RCC) who are black tend to have poorer prognosis than similar patients who are white. This study examined whether the racial disparity in RCC patient survival varies by demographic and clinical characteristics. Nearly 40,000 patients (4359 black and 34,991 white) diagnosed with invasive RCC from ...
Kazoe Yutaka - - 2012
This is a response to the comment by Anzo and Okada on our recent article published in Analytical Chemistry. Anzo and Okada estimated our experimental results for proton distribution in a 400 nm nanochannel based on the Poisson-Boltzmann theory with the Gouy-Chapman model. We consider that their comment is very ...
Wilcken Rainer - - 2012
Halogen bonding has been known in material science for decades, but until recently, halogen bonds in protein-ligand interactions were largely the result of serendipitous discovery rather than rational design. In this perspective, we provide insights into the phenomenon of halogen bonding, with special focus on its role in drug discovery. ...
Saglam Mehmet - - 2012
Abstract Abstract: Modification of sinus floor and providing adequate space for implant surgery by orthodontic tooth movement might be a predictable treatment procedure. In this case, implant therapy was performed by providing adequate space with orthodontic tooth movement in a patient has inadequate alveol height at posterior maxilla.Method: A 54 ...
Goldberg Alfred L - - 2012
The proteasome is the primary site for protein degradation in mammalian cells, and proteasome inhibitors have been invaluable tools in clarifying its cellular functions. The anticancer agent bortezomib inhibits the major peptidase sites in the proteasome's 20S core particle. It is a "blockbuster drug" that has led to dramatic improvements ...
Emerson M R - - 2012
This study quantified relationships between USDA instrument marbling measurements and LM sensory attributes (tenderness, flavor, juiciness) and shear force. Heifer (n = 390) and steer (n = 328) carcasses (all A-maturity) were selected at 4 beef processing plants in CO, KS, NE, and TX to represent 7 marbling degrees: Traces ...
Talbot N C - - 2012
Totipotent embryonic stem cell lines have not been established from ungulates; however, we have developed a somatic stem cell line from the in vitro culture of pig epiblast cells. The cell line, ARS-PICM-19, was isolated via colony-cloning and was found to spontaneously differentiate into hepatic parenchymal epithelial cell types, namely, ...
Segers Kurt - - 2012
ABSTRACT A patient with a history of Parkinson's disease and severe bilateral peripheral vision loss due to vitreous hemorrhages had complex visual hallucinations that persisted for three days and appeared every morning on awakening. The persistent nature of these hallucinations, the patient's preserved insight, and the presence of severe visual ...
Li Linlin - - 2012
Novel eggroll-like CaSnO(3) nanotubes have been prepared by a single spinneret electrospinning method followed by calcination in air for the first time. The electrospun sample as a lithium-ion battery electrode material exhibited improved cycling stability and rate capability by virtue of the high surface area and unique hollow interior structure, ...
Shih Heather H HH Global Biotherapeutics Technologies, Pfizer Global Research & Development, Cambridge, Massachusetts 02140, - - 2012
Highly specific antibodies to phosphoepitopes are valuable tools to study phosphorylation in disease states, but their discovery is largely empirical, and the molecular mechanisms mediating phosphospecific binding are poorly understood. Here, we report the generation and characterization of extremely specific recombinant chicken antibodies to three phosphoepitopes on the Alzheimer disease-associated ...
Simon Judy - - 2012
We investigated the interaction of rhizospheric nitric oxide (NO) concentration (i.e., low, ambient, or high) and soil N availability (i.e., low or high) with organic and inorganic N uptake by fine roots of Pinus sylvestris L. seedlings by (15) N feeding experiments under controlled conditions. N metabolites in fine roots ...
Wzorek Joseph S - - 2012
A new approach to the tetracycline core structure is presented. The pivotal intermediate is identified as macrocycle III. The two interior bonds (C4a-C12a and C5a-C11a) are to be constructed through sequential transannular Michael additions (III-II) and compression-promoted transannular isoxazole alkylations from intermediate II.
Dlubak Bruno - - 2012
We report on graphene-passivated ferromagnetic electrodes (GPFE) for spin devices. GPFE are shown to act as spin-polarized oxidation-resistant electrodes. The direct coating of nickel with few layer graphene through a readily scalable chemical vapour deposition (CVD) process allows the preservation of an unoxidized nickel surface upon air exposure. Fabrication and ...
Allred Clint - - 2012
Device infection is a potential complication of cardiovascular implantable electronic devices. We report a case of a 40-year-old man with nonischemic cardiomyopathy, status post biventricular implantable cardiac defilbrillator placement on continuous home dobutamine, who presented with methicillin-resistant Staphylococcus aureus bacteremia. Transesophageal echocardiography showed a 2.4 cm vegetation near the right ventricular ...
Schuurmans Josien - - 2012
In half of Obsessive Compulsive Disorder (OCD) patients the disorder runs a chronic course despite treatment. The factors determining this unfavourable outcome remain unknown. The Netherlands Obsessive Compulsive Disorder Association (NOCDA) study is a multicentre naturalistic cohort study of the biological, psychological and social determinants of chronicity in a clinical ...
Hayes John D - - 2012
AIMS: The signaling molecule hydrogen sulfide (H2S) protects cells against oxidative stress and activates NF-E2 p45-related factor-2 (Nrf2), a transcription factor that regulates antioxidant genes. We sought to establish whether H2S requires Nrf2 to protect against oxidative stress, and whether activation of Nrf2 by H2S involves antagonism of Kelch-like ECH-associated ...
Bravo Mancheño Beatriz - - 2012
Takayasu arteritis (TA) in the child remains a therapeutic challenge because corticosteroids and conventional immunosuppressive agents are not always safe or efficacious. The complex formed by interleukin-6 (IL-6) and soluble IL-6 receptor appears to play a pivotal role in the pathogenesis of TA. We describe a favorable response to the ...
Raghavender Upadhyayula Surya - - 2012
The first computational study of the folding and dynamics of a hydrophobic β-hairpin containing a central heterochiral diproline segment is reported. Linear hydrophobic sequences containing centrally positioned diproline motifs, heterochiral (DL/LD) and homochiral (LL/DD)), are investigated for their ability to form β-hairpins. Heterochiral diproline motifs (LD/DL) reveal the formation of ...
McSherry A - - 2012
ACCESSIBLE SUMMARY: Mental health nursing is in a process of redefining itself and being asked to promote mental health to a wider public, and it therefore needs to engage with ideas new to nursing. Jacques Lacan's ideas appear of particular relevance to those interested in mental health. In particular, a ...
Ciftel Murat - - 2012
Purpose There may be an increase in the risk of atrial arrhythmia due to left atrial enlargement and the influence on conduction system in acute rheumatic fever. The aim of this study is to investigate atrial electromechanical delay and P-wave dispersion in patients with acute rheumatic fever. Patients A total ...
Smith Mark A - - 2012
The rate coefficients for the forward and reverse proton transfer reaction C2H4 + H3O+ ↔ C2H5+ + H2O are studied with respect to independently varied neutral-molecule and ion temperatures. The measurements are performed using a coaxial molecular beam radiofrequency ring electrode ion trap (CoMB-RET), at trap temperatures down to 23 ...
Björkman Mikko P - - 2012
Intracellular resistance (Ri), a raw measure of bioimpedance spectroscopy (BIS), has been suggested for assessment of muscle health. The associations of repeated BIS measurements with functioning and nutritional status were investigated in nursing home residents suffering from poor health and disabilities. A total of 106 nursing home residents (age 83±8 ...
Solomon Keith R - - 2012
The article "The ecological risk assessment of atrazine in North American surface waters" [1] is one of the few among the 100 most cited articles in Environmental Toxicology and Chemistry to specifically address risk and/or assessment of risk, and it was the first to use probabilistic approaches for a pesticide. ...
Bruel Nicolas N Laboratoire de Microbiologie et Génétique Moléculaire (LMGM), Centre National de la Recherche Scientifique (CNRS) and Université Paul Sabatier, 31062 Toulouse, - - 2012
Intracellular de novo protein folding is assisted by cellular networks of molecular chaperones. In Escherichia coli, cooperation between the chaperones trigger factor (TF) and DnaK is central to this process. Accordingly, the simultaneous deletion of both chaperone-encoding genes leads to severe growth and protein folding defects. Herein, we took advantage ...
Altmann S - - 2012
Background: The implantation of endoprostheses is an established procedure in orthopaedic and trauma surgery. However, the techniques are often associated with a high risk of postinterventional infections and wound healing disorders that can result in loss of the prosthesis or the limb - most likely based on an insufficient debridement ...
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